Publications

dopamine agonists and pituitary tumor shrinkage.	the primary aim of this review has been to clarify the tumor shrinking effects of dopamine agonists on pituitary macroadenomas of different cell types. shrinkage is most dramatic for macroprolactinomas and is due to cell size reduction. seventy-nine percent of 271 definite macroprolactinomas were reduced in size by at least 25%, and 89% shrank to some degree. most shrinkage occurs during the first 3 months of treatment, although in a minority shrinkage is delayed. dopamine agonist resistance dur ...	2006	1352243
african tick-bite fever: a new spotted fever group rickettsiosis under an old name.		1992	1357393
[morbidity with temporary loss of work capacity in the workers of the belmeken-sestrimo hydroelectric cascade].	the present work presents the results from the analysis on the morbidity with temporary disability from cascade "belmeken-sestrimo" (n = 94, men 73, women 21). by means of personnel method are studied the cases of morbidity with temporary disability and defined the basic and enlarged number of indices, analysed in sex, age, length of service, nosological structure and dynamics for a period of 3 years (1987-1989) for the 3 sites of hydroelectric cascade "belmeken-sestrimo", water-power station "m ...	2005	1364540
specificity of a tumor marker (ca54/61) and its individual epitopes recognized by monoclonal antibodies, ma54 and ma61, in human tumor patients.	the specificity of a tumor marker (ca54/61) and its individual epitopes (ca54 and ca61) recognized by monoclonal antibodies (ma54 and ma61) and expressed by the same tumor marker were studied. serum levels of ca54 and ca61 were compared with that of ca54/61. in lung adenocarcinoma and ovarian carcinoma, the positive rates of ca61 (42% and 68%) were higher than those of ca54 (32% and 32%) and similar to those of ca54/61 (45% and 74%). the serum levels of ca54 and ca61 showed a significant correla ...	1992	1383482
[torsion of the colonic epiploic appendages].	operations were carried out on 21 patients with torsion of epiploic appendages of the colon (sigmoid 19, ascending 1, hepatic flexure 1). this pathologic condition has no specific manifestations and occurs under the mask of other emergencies. the suggested symptom of "pain displacement" in combination with other signs allowed the correct diagnosis to be established before the operation in two thirds of patients. patients with torsion of epiploic appendages must be subjected to an emergency opera ...	2006	1388218
health status of the temporarily homeless population and residents of north west thames region.	to survey the health status of the temporarily homeless population of north west thames region and make comparisons with regional residents.	2006	1392918
a cluster of tick-borne infections: association with military training and asymptomatic infections due to rickettsia rickettsii.	during the spring of 1989, 86 members of a military unit from the state of maryland, usa, participated in two-week-long training manoeuvres in the states of arkansas (location fc) and virginia (location faph). acute febrile illnesses due to infections with two tick-borne pathogens, rickettsia rickettsii and ehrlichia sp., were confirmed serologically in 2 initial cases who were admitted to the hospital. a seroepidemiological investigation among unit members found an additional 17 of 109 individu ...	1992	1412666
pharmaceutical promotions.		2006	1435909
experimental evidence of ischemic thresholds and functional recovery.	impaired blood flow below certain critical levels and an insufficient supply of energy-rich substrates cause failure of neuronal function, triggering biochemical disturbances that eventually lead to ischemic cell damage.	2005	1440719
demonstration and partial characterization of antigens of rickettsia rhipicephali that induce cross-reactive cellular and humoral immune responses to rickettsia rickettsii.	the relatively unrelated spotted fever group rickettsia rickettsia rhipicephali conferred on guinea pigs protective immunity against challenge with virulent r. rickettsii. immunity was conferred at all doses of r. rhipicephali used in the study. because of the serologic unrelatedness of these two rickettsiae, determined by the use of microimmunofluorescence and other serological assays, further studies were performed to define the nature of the immune response elicited by r. rhipicephali and the ...	1992	1452343
characterization and comparison of australian human spotted fever group rickettsiae.	the microbiological and molecular characteristics of the rickettsiae isolated from humans with queensland tick typhus (qtt) caused by rickettsia australis and the recently described flinders island spotted fever (fisf) were compared. clinically and serologically, the diseases are similar. cell culture reveals differences in the plaque-forming abilities of the isolates. characterization of the gene encoding the genus-specific 17-kda antigen of r. australis revealed a unique nucleotide sequence un ...	1992	1452660
nutrition and head start.		2006	1458961
the role of an adhesive (histoacryl) in tendon repair.	two in vitro experiments have been done comparing various techniques of tendon repair. these include repairs using an adhesive, 2-butyl cyanoacrylate (histoacryl), and repairs by the modified kessler technique, using 4/0 braided polyester and 4/0 stainless steel. mechanical analysis has shown that by replacing the circumferential suture of a modified kessler tendon repair with histoacryl, the tensile strength of the repair and the force needed to produce a gap can be increased by 30% to 40%. thi ...	2006	1479248
rocky mountain "spotless" and "almost spotless" fever: a wolf in sheep's clothing.	in 10 (10.8%) of 93 laboratory-confirmed or probable cases of rocky mountain spotted fever seen at duke university medical center from 1969 to 1991, illness without rash or fleeting or atypical skin eruptions were noted. data from these 10 cases and 33 similar previously reported cases of rocky mountain "spotless" or "almost spotless" fever support the premise that human rickettsia rickettsii infection has a broader spectrum than that indicated by its classic description. sixty-one percent of pa ...	1992	1520791
detection of rickettsia rickettsii in saliva, hemolymph and triturated tissues of infected dermacentor andersoni ticks by polymerase chain reaction.	the technique of polymerase chain reaction (pcr) is potentially superior to existing methods for detecting rickettsial infections in ticks. for this reason, we developed assays for identifying rickettsial infections in ticks by pcr. our assays amplified a 500 bp fragment from the gene encoding the romp b protein of rickettsia rickettsii. the selected primers amplified fragments of the predicted size from all spotted fever group rickettsiae (r. rickettsii, r. parkeri, r. conorii, r. sibirica) tes ...	1992	1528203
analysis of functional domains of endoglucanases from clostridium cellulovorans by gene cloning, nucleotide sequencing and chimeric protein construction.	the nucleotide sequence of engd, an endo-beta-1,4-glucanase gene from clostridium cellulovorans was determined (genbank accession no. m37434). the cooh-terminal part of the gene product, engd, contained a thr-thr-pro repeated sequence followed by a region that has homology to the exoglucanase of cellulomonas fimi. engd and engb, another c. cellulovorans endoglucanase, show 75% amino acid sequence homology at their nh2-termini, in contrast to their carboxyterminal domains which show no homology. ...	1992	1538700
percutaneous mitral balloon valvotomy.		2006	1538723
cell-mediated immune responses of adults to vaccination, challenge with rickettsia rickettsii, or both.	as a part of a study to evaluate a formalin-killed rickettsia rickettsii vaccine, lymphoproliferative (lt) and delayed-type hypersensitivity (dth) skin test responses to killed r. rickettsii were measured as correlates of cell-mediated immunity in volunteers who were vaccinated, challenged with r. rickettsii, or both. we detected lt responses in 26 (51%) of 51 volunteers after vaccination. after challenge, six of six unvaccinated volunteers and 12 of 16 vaccinated volunteers developed rocky moun ...	1992	1539743
analysis of leptospira spp., leptonema illini, and rickettsia rickettsii for the 39-kilodalton antigen (p39) of borrelia burgdorferi.	five serovars of leptospira interrogans, leptospira biflexa, leptonema illini, and rickettsia rickettsii were examined and found not to contain the 39-kda antigen (p39) of borrelia burgdorferi, the lyme disease spirochete. the specificity of this antigen and its reactivity with human lyme disease sera should exclude the possibility of false-positive serum samples from patients having had either leptospirosis or rocky mountain spotted fever, as well as tick-borne relapsing fever and syphilis, as ...	1992	1551994
maternal plasma fibronectin and neonatal birth weight.	similar plasma fibrinoectin levels were found in nonpregnant volunteers and first or third trimester normal pregnant women, while in preeclamptics it was two times higher. the close relationship observed between maternal plasma fibronectin content and corrected fetal birth weight suggests that the state of microcirculation has a profound influence on neonatal birth weight.	2006	1559625
[why do physicians and patients ever more often resort to practitioners of alternative medicine: the healer and the quack?].		2006	1563606
synthetic cephalosporins. viii. synthesis and antibacterial activity of cp6232, a new anti-pseudomonal cephalosporin.		1992	1592693
[perverse interactions].		2006	1594856
spotted fever rickettsiae in ticks from the northern sinai governate, egypt.	a field study was initiated in 1988 to investigate whether spotted fever group rickettsiae occur in geographic areas in egypt that are adjacent to an area in the southern israeli negev that has a defined focus of spotted fever disease. ticks were collected from dogs, sheep, and camels at four study sites in the northern sinai. tick hemolymph was processed for rickettsial detection by staining with fluorescein isothiocyanate-conjugated antibody to rickettsia rickettsii. of the 442 hemolymphs exam ...	1992	1599048
gelatin particle agglutination test for early serodiagnosis of japanese spotted fever.	a gelatin particle agglutination (pa) test for japanese spotted fever has been developed. gelatin particles were sensitized with a sonicated causative rickettsia and used as antigens. the antibodies by pa test were detected as early as days 4-7 after the onset, whereas those by indirect immunoperoxidase (ip) test were detected after days 8-11. in addition, pa titers were higher than ip titers before days 20-23. the agglutinins detected by pa test were proven to be igm because they were all sensi ...	1992	1603001
ultrastructural study of the response of cells infected in vitro with causative agent of spotted fever group rickettsiosis in japan.	the response of host cells l929 infected with causative agent of spotted fever group (sfg) rickettsiosis in japan, the katayama strain, was studied by electron microscopy. the rickettsiae penetrated the cytoplasm and multiplied here and after prolonged incubation progressed into the dilated cisternae of rough endoplasmic reticulum (rer), the perinuclear space, the deep invaginated nuclear membrane, and then the nucleoplasm of the host cells. the intranuclear rickettsiae showed different states: ...	1992	1610553
penetration of host cells by rickettsia rickettsii appears to be mediated by a phospholipase of rickettsial origin.	internalization of obligate intracellular bacteria belonging to the genus rickettsia by eukaryotic cells requires participation of both the parasitized host and the microorganism. the term "induced phagocytosis" has been used specifically to describe the entry of rickettsia prowazekii, although a similar mechanism is likely for r. rickettsii. a role for a phospholipase in the internalization process has been proposed for both of these organisms, with the strongest supporting evidence provided fo ...	1992	1612741
glutaric aciduria type i: unusual biochemical presentation.	we describe a patient with glutaryl-coenzyme a dehydrogenase deficiency, demonstrated by a residual enzyme activity of only 1% in cultured fibroblasts. although the clinical presentation was typical of glutaric aciduria type i, the urine concentrations of glutaric, glutaconic, and 3-hydroxyglutaric acids remained normal, even during episodes of clinical decompensation. an increased free glutarate level was demonstrated only in cerebrospinal fluid.	2005	1625098
epidemiology of respiratory hazards: recent advances.	a bibliographical review of epidemiological studies published over the last five years has led us to individualize the themes that have been the subject of most recent publications (table i). these research themes are not new, which shows a certain continuity in epidemiological research on the respiratory risks of occupational origin. few studies are devoted to the identification of unrecognized respiratory risks; nevertheless, the methodology used, the indicators of effects studies contribute t ...	2006	1626104
child abuse: does prosecution serve any useful purpose?		2006	1635513
myocardial entrapment by lymphoma: a cause of reversible segmental left ventricular dysfunction.		2006	1636600
oxidative inactivation of alpha 1-proteinase inhibitor by alveolar macrophages from healthy smokers requires the presence of myeloperoxidase.	the aim of this work was to study the ability of human alveolar macrophages (am) of 10 healthy smokers to inactivate alpha 1-proteinase inhibitor (alpha 1pi). purified alpha 1pi was incubated for 45 min, with human alveolar macrophages before and after stimulation by phorbol myristate acetate (pma) or opsonized zymosan. as a positive control, the same experiments were performed in parallel with blood human neutrophils (pmn). results are expressed as percentage of inactivation of alpha 1pi as eva ...	1991	1657063
[new trends in clinical neurophysiology of the spinal cord (review of the literature)].		2006	1665637
efficacy of chloramphenicol, enrofloxacin, and tetracycline for treatment of experimental rocky mountain spotted fever in dogs.	dogs were experimentally inoculated with rickettsia rickettsii to characterize the comparative efficacies of chloramphenicol, enrofloxacin, and tetracycline for the treatment of rocky mountain spotted fever (rmsf). all three antibiotics were equally effective in abrogating the clinical, hematologic, and vascular indicators of rickettsial infection. antibiotic treatment for 24 h was sufficient to decrease the rickettsemia to levels below detection by vero cell culture. early treatment with all th ...	1991	1666498
genotypic identification of rickettsiae and estimation of intraspecies sequence divergence for portions of two rickettsial genes.	dna sequences from specific genes, amplified by the polymerase chain reaction technique, were used as substrata for nonisotopic restriction endonuclease fragment length polymorphism differentiation of rickettsial species and genotypes. the products amplified using a single pair of oligonucleotide primers (derived from a rickettsial citrate synthase gene sequence) and cleaved with restriction endonucleases were used to differentiate almost all recognized species of rickettsiae. a second set of pr ...	1991	1671856
dna polymorphism in the conserved 190 kda antigen gene repeat region among spotted fever group rickettsiae.	the 190 kda protein gene of r. rickettsii (r strain) contains a large region of tandemly arranged repeats. homologous sequences were discovered within the genomes of all but one species of spotted fever group rickettsiae. southern blots showed restriction fragment length polymorphisms between species of rickettsiae indicating structural differences among repeat regions. further analysis using polymerase chain reaction techniques indicated the repeat regions vary in size among rickettsiae. in add ...	1991	1677592
genetics of rickettsiae.	classical genetic approaches useful with free-living bacteria are difficult to apply to the rickettsiae. although rickettsial mutants have been isolated over the years, the genetic basis of these mutants is unknown, limiting their usefulness. the application of molecular biological techniques to rickettsial studies has provided the opportunity to isolate and study specific genes. genes encoding metabolic enzymes from rickettsiae were cloned in escherichia coli and shown to retain their regulator ...	1991	1679397
promoter structure and expression of the 155-kda surface antigen gene of rickettsia rickettsii.		1990	1696076
species-specific monoclonal antibodies to rickettsia japonica, a newly identified spotted fever group rickettsia.	a total of 192 hybridomas were developed from mice immunized with rickettsia japonica, a newly identified spotted fever group rickettsia pathogenic for humans. of these hybridomas, 101 were species specific, 37 were spotted fever group reactive, and the other 54 were also reactive with one or more of the other pathogenic species of spotted fever group rickettsiae, rickettsia akari, rickettsia australis, rickettsia conorii, rickettsia rickettsii, and rickettsia sibrica. seven of the species-speci ...	1990	1696280
polypeptides constituting the antigenic basis for identification of rickettsia sibirica species by the standard serotyping method for spotted fever group rickettsiae.	the antigens of rickettsia sibirica, rickettsia rickettsii, and rickettsia conorii were examined by western immunoblots and the standard immunofluorescent serotyping assay with mouse anti-rickettsia sibirica serum that is used for determining the species identification of spotted fever group rickettsiae. serum was employed prior to absorption and after absorption with purified native or heated rickettsia sibirica. the unabsorbed antiserum, the antiserum absorbed with heated rickettsia sibirica a ...	1990	1697727
iloprost inhibits neutrophil-induced lung injury and neutrophil adherence to endothelial monolayers.	we hypothesized that iloprost, a long-acting prostacyclin analog, would inhibit neutrophil (pmn)-induced lung injury and decrease pmn adherence to vascular endothelium. human pmns infused into isolated buffer-perfused rat lungs subsequently stimulated with phorbol myristate acetate (pma) resulted in lung injury as assessed by the accumulation of [125i]bovine serum albumin (125i-bsa) in lung parenchyma and alveolar lavage fluid. addition of iloprost to the lung perfusate, prior to activation of t ...	1990	1698399
comparative susceptibility to mouse interferons of rickettsia tsutsugamushi strains with different virulence in mice and of rickettsia rickettsii.	three strains of rickettsia tsutsugamushi (karp, gilliam, and ta716, representing three virulence types in mice) were examined for their sensitivity to the inhibitory effects of recombinant gamma interferon (ifn-gamma) and purified ifn-alpha/beta in two cultured mouse fibroblast cell lines. the susceptibilities of another species, rickettsia rickettsii, and of encephalomyocarditis virus (emcv) were also tested for comparative purposes. ifn-gamma inhibited rickettsial replication in only one of t ...	1991	1718869
the 120 kilodalton outer membrane protein (romp b) of rickettsia rickettsii is encoded by an unusually long open reading frame: evidence for protein processing from a large precursor.	a rickettsia rickettsii outer surface membrane protein (romp b), of an apparent molecular mass of 120 kilodaltons, is a major surface antigen of the rickettsiae that displays genus, species, and sub-species specific antigenic determinants. the 5' portion of this gene was found to be unstable in plasmids, but was stably cloned in a lambda vector. the nucleotide sequence of the 5' terminus has been determined, thus completing the dna sequence of the entire gene. genetic analysis revealed an unusua ...	1991	1724278
evidence for proteolytic cleavage of the 120-kilodalton outer membrane protein of rickettsiae: identification of an avirulent mutant deficient in processing.	the 120-kda rickettsial outer membrane protein (rompb) is encoded by a gene with the capacity to encode a protein of approximately 168 kda. the carboxy-terminal end of the molecule is apparently cleaved to yield 120- and 32-kda products. both polypeptides are surface exposed and remain associated with the outer membrane of intact rickettsiae. all species of rickettsiae examined display similar cleavage of rompb. comparison of diverse species of rickettsiae demonstrate a conserved n terminus of t ...	1992	1729180
linkage of bipolar affective disorders to markers on chromosome 11p is excluded in a second lateral extension of amish pedigree 110.	linkage between markers on chromosome 11p and bipolar affective disorders can be excluded in a second large lateral extension of the original amish pedigree 110. these results, together with previous negative linkage findings, suggest that there is not one single gene on 11p conferring susceptibility for bipolar affective disorders among the old order amish.	1991	1774072
lactoferrin levels and unsaturated iron-binding capacity in colostrum of brazilian women of two socioeconomic levels.	the objective of this study was to compare lactoferrin (lf) levels and unsaturated iron-binding capacity (uibc) of colostrum from brazilian women aged 20-38 years of low (n = 28) and high (n = 15) socioeconomic level. both groups received a similar amount of supplemental iron (25-65 mg/day) during pregnancy. we also determined the relationship between lf levels and uibc, and between these components and maternal iron status. both groups (low and high socioeconomic level) showed adequate and simi ...	1991	1797281
lactoferrin levels and unsaturated iron-binding capacity in colostrum of brazilian women of two socioeconomic levels.	the objective of this study was to compare lactoferrin (lf) levels and unsaturated iron-binding capacity (uibc) of colostrum from brazilian women aged 20-38 years of low (n = 28) and high (n = 15) socioeconomic level. both groups received a similar amount of supplemental iron (25-65 mg/day) during pregnancy. we also determined the relationship between lf levels and uibc, and between these components and maternal iron status. both groups (low and high socioeconomic level) showed adequate and simi ...	1991	1797281
surveyor attachment for milling guiding planes.		2006	1800744
surveyor attachment for milling guiding planes.		2006	1800744
[surgical reperfusion and myocardial revascularization in patients with cardiogenic shock].		2006	1800823
amino acid sequence of crustacean hyperglycemic hormone (chh) from the crayfish, orconectes limosus: emergence of a novel neuropeptide family.	the primary structure of the major form of chh from sinus glands of the crayfish, orconectes limosus, was determined by manual edman microsequencing. it is a 72-residue peptide with a calculated mr of 8400 da. in the number of residues, it is identical to the chh of carcinus maenas and very similar to mih (moult inhibiting hormone) of homarus americanus. all three peptides have pglu as n-terminus in common, and val-nh2 is the c-terminal residue in orconectes and carcinus chh. six cys residues oc ...	2007	1800954
cloning, expression and sequence analysis of the gene encoding the 120 kda surface-exposed protein of rickettsia rickettsii.		1991	1809847
[anti-inflammatory activities and effect of rhizoma alismatis on immune system].	10 and 20 g/kg ig of rhizoma alismatis (ra) markedly decrease the clearance rate of charcoal particles in mice, but have no significant effect on the weight of immune organs, or on the content of serum antibody hemolysin and immunoglobulin g and the delayed footpad edema induced by sheep red blood cell. the contact dermatitis of mouse pinnae immunized with dinitrochlorobenzene is inhibited by ra when it is given before challenge. in addition, ra 20g/kg suppresses the swelling of mouse rinnae ind ...	1991	1820797
rickettsia rickettsii infection of cultured endothelial cells induces release of large von willebrand factor multimers from weibel-palade bodies.	the clinical manifestations of rocky mountain spotted fever (rmsf) result from rickettsia rickettsii (r rickettsii) infection of endothelial cells and are mediated by pathologic changes localized to the vessel, including in situ thrombosis and tissue ischemia. this study uses in vitro infection of cultured human umbilical vein endothelial cells with r rickettsii to test the hypothesis that such infection induces von willebrand factor (vwf) release from weibel-palade bodies, a process that could ...	1991	1824255
[false acute abdomen in spontaneous rupture of the rectus abdominis muscle].		2006	1831872
[false acute abdomen in spontaneous rupture of the rectus abdominis muscle].		2006	1831872
contracts for rmos in obstetrics and gynaecology.		2007	1852332
expression of inducible angiosperm promoters in a gymnosperm, picea glauca (white spruce).	electrical discharge particle acceleration was used to test the transient expression of numerous inducible angiosperm promoters in a gymnosperm picea glauca (white spruce). promoter expression was assayed in three different tissues capable of in vitro regeneration, zygotic embryos, seedlings and embryogenic callus. the promoters tested include the light-inducible arabidopsis and soybean ribulose-1,5-bisphosphate small subunit promoters and a maize phosphoenolpyruvate carboxylase promoter; a soyb ...	2003	1868222
poems syndrome: further investigations of an unusual case.		2003	1868304
in situ activation of syngeneic tumour-specific cytotoxic t lymphocytes: intra-pinna immunization followed by restimulation in the peritoneal cavity.	tumour-specific cytotoxic t lymphocytes (ctl) are usually obtained after immunization in vivo and restimulation of immune cells in vitro. we here describe the generation of syngeneic tumour-specific ctl within no more than 9 days by priming and restimulation in vivo. this is achieved only if the correct sites are used both for primary immunization (ear pinna) and for restimulation (peritoneal cavity). the kinetics of immune t cell induction and of the secondary response in vivo will be reported. ...	2006	1868488
in situ activation of syngeneic tumour-specific cytotoxic t lymphocytes: intra-pinna immunization followed by restimulation in the peritoneal cavity.	tumour-specific cytotoxic t lymphocytes (ctl) are usually obtained after immunization in vivo and restimulation of immune cells in vitro. we here describe the generation of syngeneic tumour-specific ctl within no more than 9 days by priming and restimulation in vivo. this is achieved only if the correct sites are used both for primary immunization (ear pinna) and for restimulation (peritoneal cavity). the kinetics of immune t cell induction and of the secondary response in vivo will be reported. ...	2006	1868488
effects of venous hypertension on rabbit free flap survival.	a two-stage project was developed to study the effect of increased venous pressure on blood flow and survival in microvascular free tissue transfers. a rabbit epigastric fasciocutaneous free flap model was used. the blood flow in the rabbit epigastric free flap is 1.07 +/- 0.06 ml/min. the average venous pressure is 8.6 +/- 1.7 cm water. a logarithmic relationship between blood flow and venous pressure was demonstrated, with a statistically significant decrease in blood flow to 20-35% of the con ...	1991	1895934
flinders island spotted fever: a newly recognised endemic focus of tick typhus in bass strait. part 2. serological investigations.	twenty-six cases of a spotted-fever-like illness have been identified on flinders island, tasmania, over a 17 year period. these patients and 335 healthy persons from the island were investigated serologically using the weil-felix agglutination test (proteus sp. antigens ox2, ox19, oxk) and rickettsia-specific microimmunofluorescence. the antigens used in these latter tests comprised one member of the typhus group (rickettsia typhi) and three members of the spotted fever group (rickettsia ricket ...	1991	1898756
fatal rocky mountain spotted fever in maryland--1901.		1991	1899275
in vitro susceptibilities of coxiella burnetii, rickettsia rickettsii, and rickettsia conorii to the fluoroquinolone sparfloxacin.	in vitro susceptibilities of rickettsia rickettsii, rickettsia conorii, and coxiella burnetii to the new fluoroquinolone sparfloxacin (at-4140; rp 64206) were determined. plaque and dye uptake assays were used to measure the mics against r. rickettsii and r. conorii. the susceptibilities of c. burnetii nine mile and q 212 were determined in two acute-infection models and in two chronic-infection models. the mics were 0.125 to 0.25 microgram/ml for r. rickettsii and 0.25 to 0.5 microgram/ml for r ...	1991	1901703
fine needle aspiration biopsy diagnosis of tuberculous lymphadenitis in patients with and without the acquired immune deficiency syndrome.	all bellevue hospital cases from a recent 27-month period whose fine needle aspiration (fna) samples of cervical or supraclavicular masses showed acute and/or granulomatous inflammation were reviewed. the 30 patients included 8 with the acquired immune deficiency syndrome (aids), 3 with the aids-related complex (arc), 2 with aids risk factors and 17 without known risk factors for aids. of these, mycobacterial infections had been diagnosed in 22 patients: 18 by cultures positive for mycobacterium ...	1991	1904179
rocky mountain spotted fever.	rocky mountain spotted fever, the most prevalent rickettsial disease in the united states, is one of the most severe of all infectious diseases. it remains an important infectious disease because of its prevalence, the difficulty of clinical diagnosis, potentially fatal outcome, and lack of a widely available sensitive and specific diagnostic test during the acute stage of the illness.	1991	1904897
pituitary and ovarian responses to luteinizing-hormone-releasing hormone during pregnancy and after parturition in brown hares (lepus europaeus).	female hares were given an i.v. injection of 5 micrograms luteinizing-hormone-releasing hormone (lhrh) between days 7 and 19 (n = 21), 20 and 33 (n = 17) and 34 and 41 (n = 17) of pregnancy, and in the 3 days after parturition (n = 16). whatever the stage of pregnancy, the lhrh injection induced a release of luteinizing hormone (lh) and follicle-stimulating hormone (fsh) and an acute secretion of progesterone; these hormonal responses increased significantly during pregnancy, to reach values sim ...	1999	1905354
dna base composition of rickettsia tsutsugamushi determined by reversed-phase high-performance liquid chromatography.	the dna base composition of rickettsia tsutsugamushi was determined by reversed-phase high-performance liquid chromatography and compared with that of rickettsia rickettsii. the g+c contents were 28.1 to 30.5 mol% for r. tsutsugamushi and 32.1 mol% for r. rickettsii.	1991	1906730
[gas chromatograms of fatty acids from rickettsia and their similarities].	fatty acid compositions of 7 strains of rickettsia were analyzed by a on-line gc/ms system. these strains were r. prowazekii e, r. conorii simko, r. rickettsii r, r. sibirica barbash and 246, r. sinkiangensis jinghe, and r. heilungkiangensis 54. the samples were purified by means of the concentrated salt-ether method. there were about 50 peaks in the fatty acid profiles, and 16 of these peaks were determined, i.e. c22:0, c19:0, c18:0, c18:1, c18:2, c17:0, c16:0, c16:1, 3-oh-c14:0, c15:0, c14:0, ...	1991	1907779
some contributions of electron microscopy to the study of the rickettsiae.	electron microscopy has provided valuable insights into the study of rickettsiae as intracellular parasites from several important perspectives. this tool has allowed researchers to delineate the fine structural features of these organisms and to show that they truly resemble free-living bacteria. furthermore, it has been shown that there are subtle, but distinct differences in the outer envelope structure of some members of the genus rickettsia that may explain reported differences in tinctoria ...	1991	1909242
antigenic relationships among the rickettsiae of the spotted fever and typhus groups.	using immunoblots to analyze antigenic relationships among the pathogenic spotted fever and typhus group rickettsiae, i found that the rickettsial lipopolysaccharide (lps) was a group-specific antigen. all the rickettsiae examined had 135-kda and 58-kda protein antigens. the spotted fever rickettsiae and rickettsia canada had, in addition, 190-kda protein antigens which were antigenic analogs of previously described protective antigens of r. conorii and r. rickettsii.	1991	1916232
aging and rationing.		2007	1932999
heparin protects human endothelial cells infected by rickettsia rickettsii.	routine culture of endothelial cells currently includes the use of heparin, which significantly reduces cell doubling time and increases cell population size. heparin protects cultured arterial endothelial cells from damage by toxic oxygen metabolites produced by the action of xanthine and xanthine oxidase. because of our hypothesis implicating free radicals in cell injury caused by rickettsia rickettsii, we have carried out a series of experiments to examine the effects of heparin on injury to ...	1991	1937810
granulocytic sarcoma of the submandibular lymph node preceding overt leukemia: significance of strict evaluation of bone marrow.		2007	1951190
long-term enteral feeding: a retrospective comparison of delivery via percutaneous endoscopic gastrostomy and nasoenteric tubes.	the use of percutaneous endoscopic gastrostomy (peg) tubes for enteral feeding is widespread, although their superiority to other feeding devices, such as nasoenteric tubes (net), has not been substantiated. we retrospectively compared clinical outcomes in patients who received enteral feeding via peg (n = 80) or net (n = 29) from 1984 to 1988. mean follow-up was 192 days in the peg group and 141 days in the net group. changes in nutritional and performance status were similar in both groups. as ...	2007	1951237
pyogenic meningitis and cerebral abscesses after endoscopic injection sclerotherapy.	infectious complications of endoscopic injection sclerotherapy (eis) are rare. we report here a case in which pyogenic meningitis and multiple cerebral abscesses developed after a session of eis. the patient was successfully treated with a combination of parenteral antibiotics and repeated bedside pus aspirations. prophylactic antibiotics may be considered in such situations for subsequent sessions of eis.	2007	1951249
hospital outbreak of scabies stemming from two aids patients with norwegian scabies.		2007	1971073
site and strand specificity of uvb mutagenesis in the sup4-0 gene of yeast.		1991	2000411
false-positive results in serologic tests for rocky mountain spotted fever during pregnancy.	the data from this study demonstrate that false-positive results from tests for rocky mountain spotted fever increase with the duration of pregnancy. the sera of 4.0% (2/50) of women in their first trimester of pregnancy, 10.9% (5/46) in their second trimester, and 12.1% (12/99) in their third trimester yielded false-positive results from latex agglutination assays for rickettsia rickettsii infections. the cause of these false-positive results was not determined by this study. these false-positi ...	1991	2000516
rocky mountain spotted fever.	rocky mountain spotted fever is an endemic tickborne disease found throughout the united states and other regions of the world. exposure may result in a spectrum of disease from subclinical infection to severe or fatal multiorgan collapse. the disease is maintained in nature in ixodid tick vectors and their hosts. the most important ticks in the united states are dermacentor variabilis and dermacentor andersoni. small mammals are the natural reservoirs in the wild. dogs become infected when a ti ...	1991	2014623
carotid endarterectomy in great britain and ireland: trends and current practice.	of 309 questionnaires on carotid endarterectomy sent to all surgeons in great britain and ireland who might use this technique, 298 (96 per cent) were returned. in all, 110 (37 per cent) of 298 surgeons performed at least one carotid endarterectomy in 1989; 67 performed less than 10 and 43 greater than 10. in total, these 110 surgeons performed 1417 operations in 1989, a situation that has changed little over 5 years since the previous survey. transient ischaemic attack and minor stroke remain t ...	1977	2032096
effects of amino acid infusion on renal hemodynamics. role of endothelium-derived relaxing factor.	ingestion of protein or intravenous infusion of amino acids acutely elevates glomerular filtration rate (gfr) and renal plasma flow (rpf) by unknown mechanisms. endothelium-derived relaxing factor (edrf), now known to be nitric oxide derived from metabolism of l-arginine, participates in local regulation of vascular tone. to investigate the hypothesis that edrf may participate in the renal vasodilatation and increased gfr after amino acid infusion, we characterized the effect of inhibition of ed ...	1991	2045148
[sudden death syndrome in infants in their first year of life; biological maturity and borderline conditions].		2007	2075054
measuring cholesterol. a handbook for out-patient clinics and laboratory personnel.		2007	2100407
[rocky mountain spotted fever].	after returning from a holiday in the usa a 24-year-old man fell ill with diarrhoea, high fever and marked rash including the palms of the hands and soles of the feet. when a history of a tick bite in the usa was elicited, a rickettsial infection was suspected. treatment with doxycycline, 100 mg twice daily, was instituted finally and the fever slowly resolved. the patient became completely well again within four weeks. serological tests confirmed the diagnosis of rocky mountain spotted fever.	1990	2104798
vascular permeability and coagulation during rickettsia rickettsii infection in dogs.	the vascular permeability of the ocular fundus, alterations in the coagulation system, and plasma concentrations of thromboxane b2 (txb2) and 6-keto-prostaglandin f1 alpha (6-keto-pgf1 alpha) were studied in dogs following intradermal inoculation with 5 x 10(5) tcid50 of rickettsia rickettsii. twenty-four to 48 hours after the onset of fever and rickettsemia, multifocal areas of retinal vasculitis were evident, which corresponded to areas of altered vascular permeability demonstrated by fluoresc ...	1990	2105679
serologic survey of selected zoonotic disease agents in black-tailed jack rabbits from western texas.	a serologic survey for the agents of rocky mountain spotted fever (rmsf) (rickettsia rickettsii), borrelia spp. including the causative agent for lyme disease (borrelia burgdorferi), and plague (yersinia pestis) was conducted on blood samples collected from 30 and 46 black-tailed jack rabbits (lepus californicus) from an urban environment in lubbock, texas (usa) during winter 1987 and the following spring 1988, respectively. antibody titers to the agents of rmsf and borreliosis were detected in ...	1990	2106044
a recombinant rickettsia conorii vaccine protects guinea pigs from experimental boutonneuse fever and rocky mountain spotted fever.	there are no vaccines against boutonneuse fever and rocky mountain spotted fever. previous studies have identified a rickettsia rickettsii surface protein as a vaccine candidate and shown that an antigenically related protein is present in r. conorii, which causes boutonneuse fever. the gene encoding the r. rickettsii protein has been cloned and expressed in escherichia coli. we confirmed by 7.5% sodium dodecyl sulfate-polyacrylamide gel electrophoresis of rickettsial lysates followed by immunob ...	1990	2106490
rapid immunoperoxidase demonstration of rickettsia rickettsii in fixed cutaneous specimens from patients with rocky mountain spotted fever.	immunofluorescence (if) of skin biopsies for detection of rickettsia rickettsii (rr) has proven useful as a rapid test for confirmation of rocky mountain spotted fever (rmsf). however, if lacks sensitivity, requires special equipment and training, and is difficult to interpret. the authors have developed an indirect avidin-biotin immunoperoxidase (ip) technique to detect rr in fixed and frozen tissue sections. the technique was evaluated on fixed cutaneous specimens from patients dying of rmsf a ...	1990	2106778
causative agent of spotted fever group rickettsiosis in japan.	since 1984, it has been known that spotted fever group rickettsiosis exists in japan. we isolated three strains of the causative rickettsiae, designated katayama, misaka, and abe, from patients with the disease and studied the characteristics of the isolates. nude mice and cyclophosphamide-treated mice died after infection with the isolates. however, infected normal mice recovered and acquired immunity. infected adult male guinea pigs had fever, a scrotal reaction, and seroconversion. the isolat ...	1990	2108090
diagnosis of acute typhus infection using the polymerase chain reaction.	the first use of the polymerase chain reaction (pcr) for the diagnosis of an acute rickettsial infection is described. a primer pair derived from the 17-kda antigen sequence of rickettsia rickettsii gave specific amplification of a 434-base pair dna fragment from the genome of rocky mountain spotted fever and endemic and epidemic typhus. the assay could detect as few as 30 rickettsiae. detection of pcr-amplified dna with a nonradioactive dna probe confirmed an acute infection with rickettsia pro ...	1990	2108225
secretion of tissue-type plasminogen activator and plasminogen activator inhibitor by rickettsia conorii- and rickettsia rickettsii-infected cultured endothelial cells.	hemostasis abnormalities have been described in patients with mediterranean spotted fever and rocky mountain spotted fever. evidence of the activation of the fibrinolytic system has been obtained in both diseases. after experimental rocky mountain spotted fever, an elevated level of fibrinogen was found in parallel with the activation of the fibrinolytic system and transient elevation of the tissue-type plasminogen activator. later protein is mainly synthesized by endothelial cells. the ability ...	1990	2115024
a potential protective role for thiols against cell injury caused by rickettsia rickettsii.		1990	2116100
evidence supporting the hypothesis that rickettsial virulence factors determine the severity of spotted fever and typhus group infections.		1990	2116102
possible typhus-group infection in new york state: presentation of four suspect cases.	epidemiologic investigations were recently conducted on four cases which were reported in new york state in 1986 and 1987, three of which were within one family. these included hospital chart reviews, case or family interviews, animal trappings, and ectoparasite surveys. serologic tests and immunoblots were performed on blood samples obtained from these patients. all four patients had acute febrile illnesses; two required hospitalization and one died. microimmunofluorescence test results using r ...	1990	2116104
the 17-kilodalton protein antigens of spotted fever and typhus group rickettsiae.		1990	2116105
characterization of the 120-kda surface protein gene of rickettsia rickettsii (r strain).		1990	2116108
detection of rickettsia rickettsii dna in clinical specimens by enzymatic amplification using polymerase chain reaction technology.		1990	2116111
kinetics of igm and igg responses to experimental and naturally acquired rickettsia rickettsii infection in dogs.	the kinetics of specific igm and igg antibody response was characterized in four 9-month-old beagles after inoculation of 2 x 10(2) plaque-forming units (pfu) of sheila smith strain of rickettsia rickettsii. immunoglobulin m antibodies were first detected by indirect immunofluorescence on postinoculation (pi) day 9, peaked by pi day 20, and were no longer detectable by pi day 80. immunoglobulin g antibodies became detectable between pi days 22 and 28, peaked by pi day 42, and decreased gradually ...	1990	2117411