Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| campylobacter concisus pathotypes induce distinct global responses in intestinal epithelial cells. | the epithelial response to the opportunistic pathogen campylobacter concisus is poorly characterised. here, we assessed the intestinal epithelial responses to two c. concisus strains with different virulence characteristics in caco-2 cells using rnaseq, and validated a subset of the response using qpcr arrays. c. concisus strains induced distinct response patterns from intestinal epithelial cells, with the toxigenic strain inducing a significantly more amplified response. a range of cellular fun ... | 2016 | 27677841 |
| microbiome, metabolome and inflammatory bowel disease. | inflammatory bowel disease (ibd) is a multifactorial disorder that conceptually occurs as a result of altered immune responses to commensal and/or pathogenic gut microbes in individuals most susceptible to the disease. during crohn's disease (cd) or ulcerative colitis (uc), two components of the human ibd, distinct stages define the disease onset, severity, progression and remission. epigenetic, environmental (microbiome, metabolome) and nutritional factors are important in ibd pathogenesis. whi ... | 2016 | 27681914 |
| multilocus sequence typing of campylobacter concisus from danish diarrheic patients. | the emerging enteric pathogen campylobacter concisus is associated with prolonged diarrhea and inflammatory bowel disease. previous studies have shown that c. concisus strains are very genetically diverse. nevertheless, c. concisus strains have been divided into two genomospecies, where gs1 strains have been isolated predominantly from healthy individuals, while the gs2 cluster consists of isolates primarily from diarrheic individuals. the aim of the present study was to determine the genetic di ... | 2016 | 27688814 |
| the consequences of campylobacter infection. | the purpose of this review is to provide an update on the clinical, public health and economic consequences of campylobacter infection. | 2017 | 27798443 |
| the relationship between the immune system and oral manifestations of inflammatory bowel disease: a review. | inflammatory bowel diseases (ibds) are chronic, relapsing inflammatory diseases characterized by exacerbations and remissions of the gastrointestinal tract, clinically manifested as crohn's disease and ulcerative colitis. the etiology of ibds is considered to be multi factorial, comprising environmental, immune, microbial and genetic factors. clinical signs may include abdominal pain, frequent bloody diarrheas, mucorrhea, vomiting, fever, fatigue or weight loss. changes in the oral cavity often ... | 2016 | 27833449 |
| microbial profiles and detection techniques in peri-implant diseases: a systematic review. | to describe the microbial profiles of peri-implant diseases and the main detection methods. | 2016 | 27833735 |
| azithromycin vs. placebo for the clinical outcome in campylobacter concisus diarrhoea in adults: a randomized, double-blinded, placebo-controlled clinical trial. | campylobacter concisus has been associated with prolonged mild diarrhoea, but investigations regarding the efficacy of antimicrobial treatment have not been reported previously. we initiated a phase 3, single-centre, randomized, double-blinded, placebo-controlled study comparing the efficacy of 500 mg once-daily dose of azithromycin with a 500 mg once-daily dose of placebo for three days, for the treatment of c. concisus diarrhoea in adult patients with a follow-up period of ten days. if symptom ... | 2016 | 27893820 |
| genome analysis of campylobacter concisus strains from patients with inflammatory bowel disease and gastroenteritis provides new insights into pathogenicity. | campylobacter concisus is an oral bacterium that is associated with inflammatory bowel disease. c. concisus has two major genomospecies, which appear to have different enteric pathogenic potential. currently, no studies have compared the genomes of c. concisus strains from different genomospecies. in this study, a comparative genome analysis of 36 c. concisus strains was conducted including 27 c. concisus strains sequenced in this study and nine publically available c. concisus genomes. the c. c ... | 2016 | 27910936 |
| dissecting the interplay between intestinal microbiota and host immunity in health and disease: lessons learned from germfree and gnotobiotic animal models. | this review elaborates the development of germfree and gnotobiotic animal models and their application in the scientific field to unravel mechanisms underlying host-microbe interactions and distinct diseases. strictly germfree animals are raised in isolators and not colonized by any organism at all. the germfree state is continuously maintained by birth, raising, housing and breeding under strict sterile conditions. however, isolator raised germfree mice are exposed to a stressful environment an ... | 2016 | 27980855 |
| unsupervised statistical discovery of spaced motifs in prokaryotic genomes. | dna sequences contain repetitive motifs which have various functions in the physiology of the organism. a number of methods have been developed for discovery of such sequence motifs with a primary focus on detection of regulatory motifs and particularly transcription factor binding sites. most motif-finding methods apply probabilistic models to detect motifs characterized by unusually high number of copies of the motif in the analyzed sequences. | 2017 | 28056763 |
| motility of campylobacter concisus isolated from saliva, feces, and gut mucosal biopsies. | campylobacter concisus is an emerging pathogen associated with gastrointestinal disorders such as gastroenteritis and inflammatory bowel diseases (ibd), but the species is also found in healthy subjects. the heterogeneous genome of c. concisus increases the likelihood of varying virulence between strains. flagella motility is a crucial virulence factor for the well-recognized campylobacter jejuni; therefore, this study aimed to analyze the motility of c. concisus isolated from saliva, gut biopsi ... | 2017 | 28116789 |
| erratum: genome analysis of campylobacter concisus strains from patients with inflammatory bowel disease and gastroenteritis provides new insights into pathogenicity. | 2017 | 28205571 | |
| campylobacter concisus as the etiologic agent of gastrointestinal diseases. | a number of reports on the pathogenic influence of campylobacter concisus on the human body and its role in many diseases of the gastrointestinal system, including gastroesophageal reflux disease, barrett's esophagus and inflammatory bowel disease, have appeared lately. campylobacter concisus is a gram negative bacteria which requires an anaerobic environment or microaerophilic environment with hydrogen for growth and is therefore difficult to culture. due to this difficulty, the rate of infecti ... | 2017 | 28397447 |
| azathioprine, mercaptopurine, and 5-aminosalicylic acid affect the growth of ibd-associated campylobacter species and other enteric microbes. | campylobacter concisus is a bacterium that is associated with inflammatory bowel disease (ibd). immunosuppressive drugs including azathioprine (aza) and mercaptopurine (mp), and anti-inflammatory drug such as 5-aminosalicylic acid (5-asa) are commonly used to treat patients with ibd. this study aimed to examine the effects of aza, mp, and 5-asa on the growth of ibd-associated bacterial species and to identify bacterial enzymes involved in immunosuppressive drug metabolism. a total of 15 bacteria ... | 2017 | 28424670 |
| analysis of a dual domain phosphoglycosyl transferase reveals a ping-pong mechanism with a covalent enzyme intermediate. | phosphoglycosyl transferases (pgts) are integral membrane proteins with diverse architectures that catalyze the formation of polyprenol diphosphate-linked glycans via phosphosugar transfer from a nucleotide diphosphate-sugar to a polyprenol phosphate. there are two pgt superfamilies that differ significantly in overall structure and topology. the polytopic pgt superfamily, represented by mray and weca, has been the subject of many studies because of its roles in peptidoglycan and o-antigen biosy ... | 2017 | 28630348 |
| complete genome sequence of campylobacter concisus atcc 33237(t) and draft genome sequences for an additional eight well-characterized c. concisus strains. | we report the complete genome sequence of the campylobacter concisus type strain atcc 33237 and the draft genome sequences of eight additional well-characterized c. concisus strains. c. concisus has been shown to be a genetically heterogeneous species, and these nine genomes provide valuable information regarding the diversity within this taxon. | 2017 | 28729281 |
| campylobacter concisus genomospecies 2 is better adapted to the human gastrointestinal tract as compared with campylobacter concisus genomospecies 1. | campylobacter concisus was previously shown to be associated with inflammatory bowel disease including crohn's disease (cd) and ulcerative colitis (uc). c. concisus has two genomospecies (gs). this study systematically examined the colonization of gs1 and gs2 c. concisus in the human gastrointestinal tract. gs1 and gs2 specific polymorphisms in 23s rrna gene were identified by comparison of the 23s rrna genes of 49 c. concisus strains. two newly designed pcr methods, based on the polymorphisms o ... | 2017 | 28824443 |
| incidence of campylobacter concisus and c. ureolyticus in traveler's diarrhea cases and asymptomatic controls in nepal and thailand. | campylobacter concisus and c. ureolyticus have emerged in recent years as being associated with acute and prolonged gastroenteritis and implicated in the development of inflammatory bowel diseases. however, there are limited data on the prevalence of these microorganisms in southeast asia. in this study, 214 pathogen-negative stool samples after laboratory examination for common enteric pathogens to include c. jejuni and c. coli by culture from two case-control traveler's diarrhea (td) studies c ... | 2017 | 28824712 |