Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| simple fall-off pattern of correlated neural activity in the developing lateral geniculate nucleus. | activity-dependent models for cortical simple-cell receptive field development predict specific patterns of correlated neural activity within the visual pathway, such as a mexican hat-shaped pattern of correlated activity in the lateral geniculate nucleus (lgn). however, such activity patterns have yet to be experimentally demonstrated. we performed multielectrode recordings in the lgn of immature awake ferrets and found simple fall-off-shaped, rather than mexican hat-shaped, patterns of correla ... | 2006 | 17115045 |
| predator threat induces behavioral inhibition, pituitary-adrenal activation and changes in amygdala crf-binding protein gene expression. | behavioral inhibition (bi) is an adaptive defensive response to threat; however, extreme bi is associated with anxiety-related psychopathology. when rats are exposed to a natural predator they display stress- and anxiety-related behavioral alterations and physiological activation. to develop a preclinical rodent model to study mechanisms underlying human bi and anxiety, we examined the extent to which ferret exposure elicits anxiety-related bi and hpa and amygdala activation of the crf system. i ... | 2007 | 17116372 |
| bilateral damage to the sexually dimorphic medial preoptic area/anterior hypothalamus of male ferrets causes a female-typical preference for and a hypothalamic fos response to male body odors. | previous studies showed that bilateral lesions of the male ferret's preoptic area/anterior hypothalamus (poa/ah), centered in the sexually dimorphic nuclei present in this region, caused subjects to seek out a same-sex male, as opposed to a female conspecific. male subjects with poa/ah lesions (which were also castrated and given estradiol) displayed female-typical receptive behavior in response to neck gripping by a stimulus male, implying that subjects' approaches to a same-sex conspecific wer ... | 2007 | 17118411 |
| acetylcholine synthesis, muscarinic receptor subtypes, neuropeptides and secretion of ferret salivary glands with special reference to the zygomatic gland. | studies on salivary secretion are usually focused on parotid and submandibular glands. however, the film of mucin, that protects the oral structures and is responsible for the feeling of oral comfort, is produced by the submucosal glands. the submucosal zygomatic and molar glands are particularly large in carnivores such as the ferret. comparisons between the mucous sublingual, zygomatic and molar glands, serous parotid and sero-mucous submandibular glands showed the acetylcholine synthesis, in ... | 2007 | 17123459 |
| efficacy and safety of selamectin in the treatment of otodectes cynotis infestation in domestic ferrets. | 2006 | 17127760 | |
| chronically recording with a multi-electrode array device in the auditory cortex of an awake ferret. | it is known that anesthesia depresses neural activity and inhibits cortico-cortical interactions and cortical output. hence, it is important to record from awake animals in order to better understand the full dynamic range of neural responses. we have developed a preparation for chronic, multi-electrode physiological recording in the cortex of the awake ferret. this paper discusses several of the advantages and disadvantages of the technique as well as procedures used to overcome potential compl ... | 2007 | 17134761 |
| physiological and anatomical evidence for multisensory interactions in auditory cortex. | recent studies, conducted almost exclusively in primates, have shown that several cortical areas usually associated with modality-specific sensory processing are subject to influences from other senses. here we demonstrate using single-unit recordings and estimates of mutual information that visual stimuli can influence the activity of units in the auditory cortex of anesthetized ferrets. in many cases, these units were also acoustically responsive and frequently transmitted more information in ... | 2007 | 17135481 |
| carpal myxosarcoma and forelimb amputation in a ferret (mustela putorius furo). | 2006 | 17142629 | |
| effects of melatonin administration on the clinical course of adrenocortical disease in domestic ferrets. | to evaluate the effect of oral administration of melatonin on clinical signs, tumor size, and serum steroid hormone concentrations in ferrets with adrenocortical disease. | 2006 | 17144819 |
| in vitro formulation optimization of intranasal galantamine leading to enhanced bioavailability and reduced emetic response in vivo. | the purpose of the current investigation was to optimize an intranasal (in) galantamine (an acetylcholinesterase inhibitor used for treatment of alzheimer's disease) formulation using an in vitro tissue model, to correlate those results to in vivo bioavailability, and to compare emetic response to oral dosing. a design-of-experiments (doe) based formulation screening employing an in vitro tissue model of human nasal epithelium was used to assess drug permeability, tight junction modulation, and ... | 2007 | 17174048 |
| animal models for human metapneumovirus (hmpv) infections. | since its detection in 2001 the human metapneumovirus (hmpv), a member of the paramyxoviridae family, was observed to be a serious pathogen in human respiratory infections during childhood. meanwhile, several animal models have been established to study the virus-host interactions and pathogenic effects. mainly, small laboratory animals like mice and cotton rats have been used, although the usage of these two species for hmpv research is controversially discussed and contradictious results were ... | 2007 | 17181987 |
| acute clozapine suppresses synchronized pyramidal synaptic network activity by increasing inhibition in the ferret prefrontal cortex. | recent studies have indicated that impaired neural circuitry in the prefrontal cortex is a prominent feature of the neuropathology of schizophrenia. clozapine is one of the most effective antipsychotic drugs used for this debilitating disease. despite its effectiveness, the mechanism by which clozapine acts on prefrontal cortical circuitry remains poorly understood. in this study, in vitro multiple whole cell recordings were performed in slices of the ferret prefrontal cortex. clozapine, which e ... | 2007 | 17182915 |
| high- and low-sensitivity subforms of alpha4beta2 and alpha3beta2 nachrs. | previous studies in other laboratories have shown that alpha4beta2 nicotinic acetylcholine receptor (nachr) exhibits a biphasic concentration-response relationship for ach with low and high ec50 components, and that the low ec50 component can be augmented by decreasing the alpha4:beta2 message ratio or incubating overnight in nicotine or at low temperature (zwart and vijverberg, 1998; covernton and connolly, 2000; buisson and bertrand, 2001; nelson et al., 2003; zhou et al., 2003). in the proces ... | 2006 | 17192606 |
| myofasciitis in the domestic ferret. | since late 2003, an inflammatory disease of muscle and fascia has been diagnosed in several ferrets at northwest zoopath, and this report describes the condition in 17 ferrets. it is a disease of young ferrets, characterized by rapid onset of clinical signs, high fever, neutrophilic leukocytosis, treatment failure, and death (or euthanasia). gross lesions include atrophy of skeletal muscle; red and white mottling and dilatation of the esophagus; and splenomegaly. histologically, moderate to seve ... | 2007 | 17197621 |
| cytologic diagnosis of diseases of ferrets. | cytology is a useful, rapid, inexpensive diagnostic technique that is particularly suitable for ferrets because of their small size and readily accessible organs and tissues. this article begins with a brief discussion of general cytologic information. the remainder of the article concentrates on the cytologic features of common diseases that affect ferrets. | 2007 | 17198960 |
| ocular biometry in the adult anesthetized ferret (mustela putorius furo). | a total of 44 eyes of 22 ferrets were examined by b-mode ultrasonography. four dimensions were measured: the distance from the corneal surface to the anterior lens surface (m1), the axial lens thickness (m2), the distance from the posterior lens surface to the retina (m3) and the distance from the anterior cornea to the retina (m4). the values obtained were (mean, standard deviation, range): m1: 1.31 +/- 0.16 mm (1-1.7); m2: 3.42 +/- 0.15 mm (3.2-3.7); m3: 2.26 +/- 0.11 mm (2.1-2.5); m4: 7 +/- 0 ... | 2007 | 17204128 |
| sar of a series of 5,6-dihydro-(9h)-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-alpha]pyridines as potent inhibitors of human eosinophil phosphodiesterase. | the potency and physical properties of a previously reported 7-oxo-4,5,6,7-tetrahydro-1h-pyrazolo[3,4-c]pyridine series of human eosinophil phosphodiesterase inhibitors were improved by tying the lactam moiety into a triazolo ring. the resulting 5,6-dihydro-(9h)-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-alpha]pyridine series provided nonionizable analogs with melting point properties suitable for micronization. substitution at the 3-position of the 5,6-dihydro-(9h)-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-al ... | 2007 | 17228876 |
| insights into the gyrification of developing ferret brain by magnetic resonance imaging. | the developmental mechanisms underlying the formation of human cortical convolutions (gyri and sulci) remain largely unknown. genetic causes of lissencephaly (literally 'smooth brain') would imply that disorders in neuronal migration cause the loss of cortical convolutions. however, prior studies have suggested that loss of sulci and gyri can also arise from impaired proliferation, disrupted lamination and loss of intracortical connections. to gain further insight into the mechanisms underlying ... | 2007 | 17229284 |
| studies in the embryology of the ferret. | 1911 | 17232892 | |
| reconstruction of the head end of an early ferret embryo. | 1911 | 17232893 | |
| spina bifida in the neck region of a ferret embryo 8 mm. long. | 1912 | 17232935 | |
| highly pathogenic avian influenza h5n1 virus in cats and other carnivores. | the asian lineage highly pathogenic avian influenza (hpai) h5n1 virus is a known pathogen of birds. only recently, the virus has been reported to cause sporadic fatal disease in carnivores, and its zoonotic potential has been dominating the popular media. attention to felids was drawn by two outbreaks with high mortality in tigers, leopards and other exotic felids in thailand. subsequently, domestic cats were found naturally infected and experimentally susceptible to h5n1 virus. a high susceptib ... | 2007 | 17250978 |
| mice respond differently to urine and its major volatile constituents from male and female ferrets. | our previous chemical investigation showed that the concentrations of urinary volatiles from males were much higher than those from females in the ferret (mustela furo). the current study was designed to examine the behavioral significance and ecological relevance of this difference for one of the main prey of the ferret, the house mouse (mus musculus). our data showed that male mice displayed no difference in their response to raw male and female ferret urine. however, they showed significantly ... | 2007 | 17265178 |
| mast cells in the salivary glands and tongue of the ferret: demonstration and some histochemical observations. | previous investigations failed to demonstrate mast cells in the alimentary tract and extraparietal glands of the ferret. it was decided therefore to test this and assess factors that may be of influence. major salivary glands and tongues of mature ferrets, which had been fixed in formalin-calcium, were examined by means of light microscopical histochemistry. staining of paraffin sections with techniques depending on basic dyes or esterolytic activity was carried out for conventional times with a ... | 2007 | 17266666 |
| analyses of rotational singularities in ferret visual cortex. | activity maps of spatial orientation, obtained by intrinsic optical imaging of the mammalian visual cortex, show the formation of pinwheel-like structures that rotate either clockwise or counterclockwise around zero dimensional points called singularities. any research that is oriented towards exploring the formation and physiological role of these singularities during an experiment requires an automated tool that can rapidly identify the location of these singularities. in this work we have dev ... | 2004 | 17271288 |
| a two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission. | the 1918 influenza pandemic was a catastrophic series of virus outbreaks that spread across the globe. here, we show that only a modest change in the 1918 influenza hemagglutinin receptor binding site alters the transmissibility of this pandemic virus. two amino acid mutations that cause a switch in receptor binding preference from the human alpha-2,6 to the avian alpha-2,3 sialic acid resulted in a virus incapable of respiratory droplet transmission between ferrets but that maintained its letha ... | 2007 | 17272724 |
| the effects of combined antioxidant (beta-carotene, alpha-tocopherol and ascorbic acid) supplementation on antioxidant capacity, dna single-strand breaks and levels of insulin-like growth factor-1/igf-binding protein 3 in the ferret model of lung cancer. | insulin-like growth factor 1 (igf-1) and its major binding protein, igf binding protein 3 (igfbp-3) are implicated in lung cancer and other malignancies. we have previously shown that the combination of three major antioxidants [beta-carotene (bc), alpha-tocopherol (at) and ascorbic acid (aa)] can prevent lung carcinogenesis in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (nnk)-treated and smoke-exposed (sm) ferret model, which is highly analogous to humans. the present study is aimed at det ... | 2007 | 17278094 |
| early cytokine mrna expression profiles predict morbillivirus disease outcome in ferrets. | severe immunosuppression is a hallmark of morbillivirus infections. to study the underlying mechanisms, we have developed a ferret model of canine distemper virus infection. the model reproduces all clinical signs of measles, but the lack of ferret-specific reagents has limited the characterization of the cellular immune response. towards this, we cloned ferret cytokines and established semi-quantitative real-time pcr assays. to demonstrate the utility of these assays we compared the cytokine pr ... | 2007 | 17289104 |
| ghrelin selectively reduces mechanosensitivity of upper gastrointestinal vagal afferents. | ghrelin is a peptide released from gastric endocrine cells that has an orexigenic effect via a vagal pathway. here we determine the effect of ghrelin on mechanosensitivity of upper-intestinal vagal afferent fibers in ferret and mouse. the responses of gastroesophageal vagal afferents to graded mechanical stimulation were determined in vitro before and during application of ghrelin to their peripheral endings. three types of vagal afferent were tested: tension receptors responding to circumferent ... | 2007 | 17290011 |
| metal-responsive gene regulation and metal transport in helicobacter species. | helicobacter species are among the most successful colonizers of the mammalian gastrointestinal and hepatobiliary tract. colonization is usually lifelong, indicating that helicobacter species have evolved intricate mechanisms of dealing with stresses encountered during colonization of host tissues, like restriction of essential metal ions. the recent availability of genome sequences of the human gastric pathogen helicobacter pylori, the murine enterohepatic pathogen helicobacter hepaticus and th ... | 2007 | 17294126 |
| efficacy of oseltamivir therapy in ferrets inoculated with different clades of h5n1 influenza virus. | highly pathogenic h5n1 influenza viruses have infected an increasing number of humans in asia, with high mortality rates and the emergence of multiple distinguishable clades. it is not known whether antiviral drugs that are effective against contemporary human influenza viruses will be effective against systemically replicating viruses, such as these pathogens. therefore, we evaluated the use of the neuraminidase (na) inhibitor oseltamivir for early postexposure prophylaxis and for treatment in ... | 2007 | 17296744 |
| temporal symmetry in primary auditory cortex: implications for cortical connectivity. | neurons in primary auditory cortex (ai) in the ferret (mustela putorius) that are well described by their spectrotemporal response field (strf) are found also to have a distinctive property that we call temporal symmetry. for temporally symmetric neurons, every temporal cross-section of the strf (impulse response) is given by the same function of time, except for a scaling and a hilbert rotation. this property held in 85% of neurons (123 out of 145) recorded from awake animals and in 96% of neur ... | 2007 | 17298227 |
| the effect of inflammation on fos expression in the ferret trigeminal nucleus. | we have previously carried out detailed characterization and identification of fos expression within the trigeminal nucleus after tooth pulp stimulation in ferrets. the aim of this study was to determine the effect of pulpal inflammation on the excitability of central trigeminal neurons following tooth pulp stimulation. adult ferrets were prepared under anesthesia to allow tooth pulp stimulation, recording from the digastric muscle, and intravenous injections at a subsequent experiment. in some ... | 2007 | 17305715 |
| action of cyclooxygenase inhibitors and a leukotriene biosynthesis inhibitor on cisplatin-induced acute and delayed emesis in the ferret. | cisplatin at 5 mg/kg, i.p. induced an acute (day 1) and delayed (days 2 and 3) emetic response in the ferret that was used to investigate the anti-emetic activity of the non-selective cyclooxygenase inhibitor indomethacin (3 - 30 mg/kg, i.p., three times per day) and two cyclooxygenase-2 inhibitors, dfu [5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl)phenyl-2(5h)-furanone; 1 - 10 mg/kg, i.p. administered at 40 and 48 h] and l-745,337 [5-methanesulphonamido-6-(2,4-diflurothiophenyl)-1-indan ... | 2007 | 17310074 |
| time course of cerebellar morphological development in postnatal ferrets: ontogenetic and comparative perspectives. | we provide the first systematic description of the morphological ontogenesis of the ferret cerebellum and compare its relative time-course to that of the rat cerebellum. overall cerebellar size, foliation, and thickness of cortical layers were quantified and purkinje cell morphology was characterized at 24 timepoints in ferrets from postnatal day (p)1 to p63. the ferret cerebellum was substantially larger than that of the rat and had a much longer developmental period. in ferrets, purkinje cells ... | 2007 | 17311324 |
| nonbacterial thrombotic endocarditis in a ferret (mustela putorius furo). | a 4-yr-old male ferret (mustela putorius furo) was presented with a 3-day history of pelvic limb ataxia and weakness. a cellulitis associated with a deep bite wound was identified and initially treated with antibiotics and anti-inflammatory medication. two weeks later, a grade iv/vi cardiac murmur was identified on physical examination. echocardiographic examination revealed irregular thickening of the aortic valve leaflets, with normal chamber dimensions and normal systolic function. the ferret ... | 2006 | 17312802 |
| physiological and behavioral studies of spatial coding in the auditory cortex. | despite extensive subcortical processing, the auditory cortex is believed to be essential for normal sound localization. however, we still have a poor understanding of how auditory spatial information is encoded in the cortex and of the relative contribution of different cortical areas to spatial hearing. we investigated the behavioral consequences of inactivating ferret primary auditory cortex (a1) on auditory localization by implanting a sustained release polymer containing the gaba(a) agonist ... | 2007 | 17314017 |
| random mutagenesis to identify novel helicobacter mustelae virulence factors. | helicobacter mustelae is a gastric pathogen of ferrets, where it causes disorders similar to those caused by helicobacter pylori in humans. the h. mustelae ferret model therefore has potential for the in vivo study of helicobacter pathogenesis in general. in this study a library of 500 individual h. mustelae mutants was generated using an in vitro random insertion mutagenesis technique. mutants were subsequently tested for motility and adherence, and 43 of the 500 mutants tested were found to be ... | 2007 | 17316371 |
| high-throughput immunophenotyping of 43 ferret lymphomas using tissue microarray technology. | to validate the use of the tissue microarray (tma) method for immunophenotyping of ferret lymphomas, a tma was constructed containing duplicate 1-mm cores sampled from 112 paraffin-embedded lymphoma tissue specimens obtained from 43 ferret lymphoma cases. immunohistochemical (ihc) expression of cd3, cd79alpha, and ki-67 (mib-1) was determined by tma and whole mount (wm) staining of each individual case for result comparison. there was a high correlation between cd79alpha and cd3 results comparin ... | 2007 | 17317796 |
| synaptophysin and insulin-like growth factor-1 immunostaining in the central nucleus of the inferior colliculus in adult ferrets following unilateral cochlear removal: a densitometric analysis. | in the present study, unilateral cochlear ablations were performed in adult ferrets to evaluate possible time-dependent modifications of synaptophysin and insulin-like growth factor-1 (igf-1) in the central nucleus of the inferior colliculus (cnic). using densitometric analysis, synaptophysin and igf-1 immunostaining were assessed at 1 (pa1) and 90 (pa90) days after cochlear ablation. the results demonstrated that 1 day after the lesion there was an increase in the levels of synaptophysin immuno ... | 2007 | 17318882 |
| development of banded afferent compartments in the inferior colliculus before onset of hearing in ferrets. | axonal projections from the lateral superior olivary nuclei (lso), as well as from the dorsal cochlear nucleus (dcn) and dorsal nucleus of the lateral lemniscus (dnll), converge in frequency-ordered layers in the central nucleus of the inferior colliculus (ic) where they distribute among different synaptic compartments. a carbocyanine dye, 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (dii), was used as a tracer to study the postnatal development of axonal projections in the ... | 2007 | 17324524 |
| does attention play a role in dynamic receptive field adaptation to changing acoustic salience in a1? | acoustic filter properties of a1 neurons can dynamically adapt to stimulus statistics, classical conditioning, instrumental learning and the changing auditory attentional focus. we have recently developed an experimental paradigm that allows us to view cortical receptive field plasticity on-line as the animal meets different behavioral challenges by attending to salient acoustic cues and changing its cortical filters to enhance performance. we propose that attention is the key trigger that initi ... | 2007 | 17329048 |
| microenvironmental adaptations in the parotid of ferret investigated by electron microscopy. | previous histochemical investigations suggested that the microenvironment in the parotid of ferret would foster microlithiasis because of a combination of pockets of inefficient secretion, brisk phagy and secretory material rich in calcium. we have undertaken the present ultrastructural investigation in an attempt to provide corroborative evidence. parotids from four normal ferrets were examined by electron microscopy. phagosomes in which there was cellular debris and occasionally secretory gran ... | 2007 | 17331462 |
| influenza virus-like particles elicit broader immune responses than whole virion inactivated influenza virus or recombinant hemagglutinin. | influenza virus is a highly infectious respiratory pathogen that results in severe morbidity and mortality. the current licensed trivalent vaccine formulations in the u.s. are made from virus grown in allantoic fluid from infected hen eggs that is then chemically inactivated and split into subunit components. these vaccines elicit antibodies, primarily to the viral hemagglutinin (ha), which are efficacious in healthy adults, but are limited in protecting high risk individuals, such as the elderl ... | 2007 | 17337102 |
| ultrasonographic visualization of the adrenal glands of healthy ferrets and ferrets with hyperadrenocorticism. | a protocol was developed to compare the ultrasonographic characteristics of the adrenal glands of 21 healthy ferrets and 37 ferrets with hyperadrenocorticism. by using specific landmarks, the adrenal glands were imaged in 97% of the cases. the adrenal glands of ferrets with hyperadrenocorticism had a significantly increased thickness, with changes in shape, structure, and echogenicity compared to the adrenal glands of healthy ferrets. based on the findings of the study, adrenal glands may be cla ... | 2016 | 17339284 |
| acquisition, extinction, and reacquisition of a cerebellar cortical memory trace. | associative learning in the cerebellum underlies motor memories and probably also cognitive associations. pavlovian eyeblink conditioning, a widely used experimental model of such learning, depends on the cerebellum, but the memory locus within the cerebellum as well as the underlying mechanisms have remained controversial. to date, crucial information on how cerebellar purkinje cells change their activity during learning has been ambiguous and contradictory, and there is no information at all a ... | 2007 | 17344387 |
| a test of mink microsatellite markers in the ferret: amplification and sequence comparisons. | short tandem repeats are a source of highly polymorphic markers in mammalian genomes. genetic variation at these hypervariable loci is extensively used for linkage analysis and to identify individuals, and is very useful for interpopulation and interspecies studies. fifty-nine microsatellite markers from american mink were tested in the ferret, under the same conditions as for the mink. of the 59, 43 of them (73.5%) amplified a ferret sequence; 5 amplification products differed in size from the ... | 2006 | 17362355 |
| a normal radial glial scaffold is necessary for migration of interneurons during neocortical development. | the relationship between radial glia and neurons migrating tangentially from the ganglionic eminence (ge) has been suggested but not firmly established. to study this relationship we used a ferret model of cortical dysplasia where radial glia are highly disorganized. to produce this, an antimitotic, methylazoxy methanol (mam) is injected on the 24th day of gestation (e24 mam). neurons migrating away from the ge in mam-treated animals tend to remain in the intermediate zone (iz) and do not reach ... | 2007 | 17366550 |
| quantitative multiplex assay for simultaneous detection of the indiana serotype of vesicular stomatitis virus and hiv gag. | assessment of in vivo viral replication of live attenuated recombinant vesicular stomatitis virus (rvsv) vaccine vector candidates encoding hiv gag requires comprehensive preclinical safety studies, and development of sensitive assays to monitor the outcome of vaccination of animals is important. in this study, two 2-step quantitative real-time rt-pcr assays were developed; a singleplex assay to detect vsv genomic rna from ferrets inoculated intra-cranially (ic) or intra-nasally (in) with either ... | 2007 | 17382412 |
| evaluation of influenza virus-like particles and novasome adjuvant as candidate vaccine for avian influenza. | the development of safe and effective vaccines for avian influenza viruses is a priority for pandemic preparedness. adjuvants improve the efficacy of vaccines and may allow antigen sparing during a pandemic. we have previously shown that influenza virus-like particles (vlps) comprised of ha, na, and m1 proteins represent a candidate vaccine for avian influenza h9n2 virus [pushko p, tumpey tm, fang bu, knell j, robinson r, smith g. influenza virus-like particles comprised of the ha, na, and m1 pr ... | 2007 | 17403562 |
| comparison of neutralising antibody assays for detection of antibody to influenza a/h3n2 viruses: an international collaborative study. | a study was performed to investigate the reproducibility of haemagglutinin-inhibition (hi) and virus neutralising (vn) assays for detection of anti-influenza antibody. participants in 11 laboratories from eight countries measured antibody to egg-grown a/japan/434/2003, cell-grown a/japan/434/2003 and a/panama/2007/99 (h3n2) viruses in 18 human and two post-infection ferret sera. there was significant intra-laboratory assay variability for vn compared to hi. for replicate assays within laboratori ... | 2007 | 17412461 |
| refining indications for the use of mitomycin c using a randomized controlled trial with an animal model. | to evaluate the effect of mitomycin on the repair of acquired subglottic stenosis and to define the optimal concentration of mitomycin that would minimize restenosis after repair. | 2007 | 17418268 |
| an improved plaque reduction virus neutralization assay for human metapneumovirus. | virus-neutralizing antibodies against human metapneumovirus (hmpv) have been shown to be important indicators for protection in experimental animal models. an improved plaque reduction virus neutralization assay to detect hmpv-specific neutralizing antibodies was designed using two prototype recombinant hmpv strains expressing green fluorescent protein (gfp). these prototypes represented each of the main antigenic variants of hmpv, because antigenic variability could have implications for vaccin ... | 2007 | 17420056 |
| infectious canine hepatitis modified live virus vaccine produced in ferret kidney cells. | 1960 | 17421172 | |
| possibility of virally induced lymphoma in pet ferrets. | 1983 | 17422287 | |
| hyperadrenocorticism in association with an adrenocortical adenoma in a pet ferret. | 1989 | 17423213 | |
| hyperadrenocorticism in a ferret. | 1989 | 17423314 | |
| splenic lymphosarcoma in a ferret. | 1989 | 17423382 | |
| web-based method for translating neurodevelopment from laboratory species to humans. | biomedical researchers and medical professionals are regularly required to compare a vast quantity of neurodevelopmental literature obtained from an assortment of mammals whose brains grow at diverse rates, including fast developing experimental rodent species and slower developing humans. in this article, we introduce a database-driven website, which was created to address this problem using statistical-based algorithms to integrate hundreds of empirically derived developing neural events in 10 ... | 2007 | 17426354 |
| cryptosporidium and giardia in marine-foraging river otters (lontra canadensis) from the puget sound georgia basin ecosystem. | species of cryptosporidium and giardia can infect humans and wildlife and have the potential to be transmitted between these 2 groups; yet, very little is known about these protozoans in marine wildlife. feces of river otters (lontra canadensis), a common marine wildlife species in the puget sound georgia basin, were examined for species of cryptosporidium and giardia to determine their role in the epidemiology of these pathogens. using znso4 flotation and immunomagnetic separation, followed by ... | 2007 | 17436965 |
| genome sequence of a clinical isolate of campylobacter jejuni from thailand. | campylobacter jejuni cg8486, which belongs to the hs4 complex, was isolated from a patient with inflammatory diarrhea in thailand. this strain caused a diarrheal disease in ferrets comparable to that caused by c. jejuni strain 81-176, but it was much less invasive for epithelial cells in vitro than 81-176. complete genome sequencing of cg8486 revealed a 1.65-mb genome that was very similar to the other two published genomes of clinical isolates of c. jejuni, the genomes of 81-176 and nctc 11168, ... | 2007 | 17438034 |
| alteration of interneuron migration in a ferret model of cortical dysplasia. | during cerebral cortical development, gamma-aminobutyric acidergic (gabaergic) interneurons arise from a different site than projection neurons. gabaergic cells are generated in the subpallial ganglionic eminence (ge), while excitatory projection neurons arise from the neocortical ventricular zone. our laboratory studies a model of cortical dysplasia that displays specific disruption of gabaergic mechanisms and an alteration in the overall balance of excitation in the neocortex. to produce this ... | 2008 | 17443019 |
| arvanil, anandamide and n-arachidonoyl-dopamine (nada) inhibit emesis through cannabinoid cb1 and vanilloid trpv1 receptors in the ferret. | cannabinoid (cb) agonists suppress nausea and vomiting (emesis). similarly, transient receptor potential vanilloid-1 (trpv1) receptor agonists are anti-emetic. arvanil, n-(3-methoxy-4-hydroxy-benzyl)-arachidonamide, is a synthetic 'hybrid' agonist of cb1 and trpv1 receptors. anandamide and n-arachidonoyl-dopamine (nada) are endogenous agonists at both these receptors. we investigated if arvanil, nada and anandamide were anti-emetic in the ferret and their mechanism of action. all compounds reduc ... | 2007 | 17459108 |
| inefficient transmission of h5n1 influenza viruses in a ferret contact model. | the abilities to infect and transmit efficiently among humans are essential for a novel influenza a virus to cause a pandemic. to evaluate the pandemic potential of widely disseminated h5n1 influenza viruses, a ferret contact model using experimental groups comprised of one inoculated ferret and two contact ferrets was used to study the transmissibility of four human h5n1 viruses isolated from 2003 to 2006. the effects of viral pathogenicity and receptor binding specificity (affinity to syntheti ... | 2007 | 17459930 |
| detection of a novel and highly divergent coronavirus from asian leopard cats and chinese ferret badgers in southern china. | since an outbreak of severe acute respiratory syndrome (sars) was averted in 2004, many novel coronaviruses have been recognized from different species, including humans. bats have provided the most diverse assemblages of coronaviruses, suggesting that they may be the natural reservoir. continued virological surveillance has proven to be the best way to avert this infectious disease at the source. here we provide the first description of a previously unidentified coronavirus lineage detected fro ... | 2007 | 17459938 |
| amyloidosis in the black-footed ferret (mustela nigripes). | this study describes clinical, histologic, immunohistochemical and electron microscopic features of amyloid a amyloidosis occurring in black-footed ferrets (mustela nigripes) from eight u.s. zoological institutions. ferrets had nonregenerative anemia, serum chemistries consistent with chronic renal disease, and proteinuria. amyloid was present in a variety of tissues, but it was most severe in renal glomeruli and associated with tubular protein loss and emaciation. congo red/potassium permangana ... | 2007 | 17469273 |
| controllable versus uncontrollable stressors bi-directionally modulate conditioned but not innate fear. | fear conditioning and fear extinction play key roles in the development and treatment of anxiety-related disorders, yet there is little information concerning experiential variables that modulate these processes. here we examined the impact of exposure to a stressor in a different environment on subsequent fear conditioning and extinction, and whether the degree of behavioral control that the subject has over the stressor is of importance. rats received a session of either escapable (controllabl ... | 2007 | 17478046 |
| similarities of the neuronal circuit for the induction of fictive vomiting between ferrets and dogs. | previous studies suggested that the following neuronal circuit participates in the induction of vomiting by afferent vagal stimulation in decerebrated paralyzed dogs: (1) afferent fibers of the vagus nerve, (2) neurons of the solitary nucleus (nts), (3) neurons of the prodromal sign center near the semicompact part of the nucleus ambiguus (scamb), (4) neurons of the central pattern generator in the reticular area adjacent to the compact part of nucleus ambiguus (camb), (5) respiratory premotor n ... | 2007 | 17478125 |
| neuronal vacuolation in an adult ferret. | the brain of a ferret showing abnormal neurologic signs was evaluated by histopathologic, histochemical, immunohistochemical, and ultrastructural examinations. extensive neuronal vacuolation was observed. since the brain was negative for protease-resistant protein prion (prp'"), it was concluded that this was not a case of transmissible spongiform encephalopathy. | 2007 | 17494365 |
| low ph gel intranasal sprays inactivate influenza viruses in vitro and protect ferrets against influenza infection. | developing strategies for controlling the severity of pandemic influenza is a global public health priority. in the event of a pandemic there may be a place for inexpensive, readily available, effective adjunctive therapies to support containment strategies such as prescription antivirals, vaccines, quarantine and restrictions on travel. inactivation of virus in the intranasal environment is one possible approach. the work described here investigated the sensitivity of influenza viruses to low p ... | 2007 | 17509128 |
| three-dimensional fibre-type distribution in the paravertebral muscles of the domestic ferret (mustela putorius f. furo) with relation to functional demands during locomotion. | we investigated the functional corollaries of a relatively long trunk with regard to trunk use during overground and underground locomotion and with regard to fibre-type distribution within the paravertebral musculature using the example of the domestic ferret. fibre-type distribution was determined using enzyme histochemistry on serial cross-sections through the complete musculo-skeletal apparatus. back posture and back movements were analysed using cineradiography. during overground locomotion ... | 2007 | 17512707 |
| use of behavior analysis to recognize pain in small mammals. | the minimization of pain in laboratory animals is a gold standard with implications for improvements in both animal welfare and research quality. changes in behavioral parameters may indicate that an animal is in pain, but in order to effectively use behavioral change to assess pain, the observer must be familiar with normal behaviors. the author discusses normal and pain-related behaviors exhibited by rodents, rabbits, and ferrets. | 2007 | 17519944 |
| cannabinoid cb1 receptor inverse agonists and neutral antagonists: effects on food intake, food-reinforced behavior and food aversions. | drugs that interfere with cannabinoid cb1 receptor transmission suppress a number of food-related behaviors, and these compounds are currently being assessed for their potential utility as appetite suppressants. in addition to rimonabant (sr141716a), several other compounds have been evaluated, including am251 and am1387. biochemical studies indicate that most of the drugs assessed thus far have been cb1 inverse agonists, and these drugs all act to suppress food intake and disrupt food-reinforce ... | 2007 | 17521686 |
| a critical period for the impact of vestibular sensation on ferret motor development. | children with hearing deficits and hypofunctioning vestibular receptors frequently have delayed motor development. this study focuses on when the vestibular system needs to be active for normal motor behavior development and the maturation of the soleus muscle in the ferret. both vestibular labyrinths were removed from ferrets at postnatal day 10 (p10), p21, or p45 and the resulting data were compared with ferrets that had undergone a sham surgery at the same ages. the animals were sacrificed at ... | 2006 | 17538206 |
| a new record of paragonimus other than p. westermani in southern thailand. | field surveys of paragonimus in surat thani province, southern thailand, revealed a new record of a lung fluke species other than p. westermani. the metacercariae were obtained from the crab, ranguna smalleyi. the cysts of the metacercariae were spherical in shape and the larval body in the cysts contained pinkish granules. fully mature adult worms were obtained from experimental infections with a rat and a ferret. the adult worms from the two host animals resembled each other, except for size, ... | 2006 | 17547054 |
| influenza (h5n1) viruses in poultry, russian federation, 2005-2006. | we studied 7 influenza (h5n1) viruses isolated from poultry in western siberia and the european part of the russian federation during july 2005-february 2006. full genome sequences showed high homology to qinghai-like influenza (h5n1) viruses. phylogenetic analysis not only showed a close genetic relationship between the h5n1 strains isolated from poultry and wild migratory waterfowls but also suggested genetic reassortment among the analyzed isolates. analysis of deduced amino acid sequences of ... | 2007 | 17553267 |
| molecular changes in the polymerase genes (pa and pb1) associated with high pathogenicity of h5n1 influenza virus in mallard ducks. | the highly pathogenic (hp) influenza viruses h5 and h7 are usually nonpathogenic in mallard ducks. however, the currently circulating hp h5n1 viruses acquired a different phenotype and are able to cause mortality in mallards. to establish the molecular basis of this phenotype, we cloned the human a/vietnam/1203/04 (h5n1) influenza virus isolate that is highly pathogenic in ferrets, mice, and mallards and found it to be a heterogeneous mixture. large-plaque isolates were highly pathogenic to duck ... | 2007 | 17553873 |
| efficient in vitro amplification of chronic wasting disease prpres. | chronic wasting disease (cwd) of cervids is associated with conversion of the normal cervid prion protein, prp(c), to a protease-resistant conformer, prp(cwd). here we report the use of both nondenaturing amplification and protein-misfolding cyclic amplification (pmca) to amplify prp(cwd) in vitro. normal brains from deer, transgenic mice expressing cervid prp(c) [tg(cerprp)1536 mice], and ferrets supported amplification. pmca using normal tg(cerprp)1536 brains as the prp(c) substrate produced > ... | 2007 | 17553879 |
| adenovirus-based vaccine prevents pneumonia in ferrets challenged with the sars coronavirus and stimulates robust immune responses in macaques. | a ferret model of severe acute respiratory syndrome (sars)-cov infection was used to evaluate the efficacy of an adenovirus vaccine. animals were subjected to heterologous prime-boost using vectors from human serotype 5 and chimpanzee derived adenoviruses (human adhu5 and chimpanzee adc7) expressing spike protein followed by intranasal challenge with sars-cov. vaccination led to a substantial reduction in viral load and prevented the severe pneumonia seen in unvaccinated animals. the same prime- ... | 2007 | 17559989 |
| emergency medicine of the ferret. | common emergency conditions seen in the ferret include insulinoma, cardiomyopathy, and urethral obstruction. when developing a diagnostic and therapeutic plan, the ferret veterinarian must seek a balance between species-specific information and information extrapolated from cat and dog medicine. the therapeutic plan must always include close and careful monitoring. significant changes in the status of these small patients can occur extremely quickly in the course of providing basic supportive ca ... | 2007 | 17577560 |
| deficits of visual motion perception and optokinetic nystagmus after posterior suprasylvian lesions in the ferret (mustela putorius furo). | we recently described an area in the ferret posterior suprasylvian (pss) cortex characterized by a high proportion of direction selective neurons. to answer the question whether area pss subserves functions similar to cat posteromediolateral suprasylvian area (pmls) and monkey medial temporal area (mt) we investigated the contribution of area pss to visual motion perception and optokinetic nystagmus. ferrets were tested on global motion detection before and after bilateral lesions involving area ... | 2007 | 17593360 |
| role of auditory cortex in sound localization in the midsagittal plane. | although the auditory cortex is known to be essential for normal sound localization in the horizontal plane, its contribution to vertical localization has not so far been examined. in this study, we measured the acuity with which ferrets could discriminate between two speakers in the midsagittal plane before and after silencing activity bilaterally in the primary auditory cortex (a1). this was achieved either by subdural placement of elvax implants containing the gaba a receptor agonist muscimol ... | 2007 | 17596417 |
| phenotypic properties resulting from directed gene segment reassortment between wild-type a/sydney/5/97 influenza virus and the live attenuated vaccine strain. | widespread use of a live-attenuated influenza vaccine (laiv) in the united states (licensed as flumist) raises the possibility that vaccine viruses will contribute gene segments to the type a influenza virus gene pool. progeny viruses possessing new genotypes might arise from genetic reassortment between circulating wild-type (wt) and vaccine strains, but it will be difficult to predict whether they will be viable or exhibit novel properties. to begin addressing these uncertainties, reverse-gene ... | 2007 | 17599381 |
| slow cooling prevents cold-induced damage to sperm motility and acrosomal integrity in the black-footed ferret (mustela nigripes). | the endangered black-footed ferret (mustela nigripes) has benefited from artificial insemination; however, improved sperm cryopreservation protocols are still needed. the present study focused on identifying factors influencing gamete survival during processing before cryopreservation, including: (1) the presence or absence of seminal plasma; (2) temperature (25 degrees c v. 37 degrees c); (3) type of medium (ham's f10 medium v. test yolk buffer [tyb]); (4) cooling rate (slow, rapid and ultra-ra ... | 2007 | 17601413 |
| effect of propafenone on kv1.4 inactivation. | interactions between antiarrhythmic drugs and ion channels are important subjects in the field of cardiovascular electro-pharmacology. this study explores the relationship between propafenone and c-type inactivation of kv1.4 channel. fkvl.4deltan, a ferret kv1.4 n-terminal deleted mutant, was employed in this study. fkvl.4deltan crna was injected into xenopus oocytes to express fkvl.4deltan channel and two electrode voltage clamp technique was used to record the current. we found that fkvl.4delt ... | 2006 | 17615952 |
| evaluation of replication and pathogenicity of avian influenza a h7 subtype viruses in a mouse model. | avian influenza a h7 subtype viruses pose a significant threat to human health because of their ability to transmit directly from domestic poultry to humans and to cause disease and, sometimes, death. although it is important to develop vaccines against viruses of this subtype, very limited information is available on the immune response and pathogenesis of h7 viruses in animal models such as mice and ferrets. ten h7 viruses were selected for possible vaccine development on the basis of their ph ... | 2007 | 17634234 |
| disease manifestations of canine distemper virus infection in ferrets are modulated by vitamin a status. | the measles virus (mv) causes half a million childhood deaths annually. vitamin a supplements significantly reduce measles-associated mortality and morbidity. the mechanisms whereby vitamin a acts against mv are not understood and currently there is no satisfactory small animal model for mv infection. we report on the development of a ferret model to study antiviral activity of vitamin a against canine distemper virus (cdv). cdv is closely related to mv at the molecular level and distemper in fe ... | 2007 | 17634264 |
| challenges in cryopreserving endangered mammal spermatozoa: morphology and the value of acrosomal integrity as markers of cryo-survival. | the science of cryobiology is essential to the effective, practical use of semen for assisted breeding to help manage small populations of rare wildlife species. in this review, we describe challenges associated with cryopreserving gametes from wild fauna. based on more than 25 years of experience across a diversity of mammals, it appears that the primary driving force dictating cryo-survival of a spermatozoon is its initial pre-freeze quality and morphology, especially having a morphologically ... | 2007 | 17644982 |
| outcomes of adoption of adult laboratory ferrets after gonadectomy during a veterinary student teaching exercise. | we surveyed 27 people who had adopted a total of 43 adult domestic ferrets after their use in a series of veterinary student surgery teaching laboratories to assess the success of those adoptions and to determine the rate of occurrence of common maladies of domestic ferrets after adult gonadectomy as compared with the usual practice of early-age gonadectomy. the adoptions took place 1-7 y prior to the survey. the response rate was 48% of adopters, covering 53% of the ferrets. overall the success ... | 2007 | 17645296 |
| distemper studies in ferrets: i. attempted conversion of a virus strain from a viscerotropic to a neurotropic form. | 1942 | 17647857 | |
| distemper studies in ferrets-part ii: ii. tissue vaccines prepared from viscerotropic distemper virus. | 1942 | 17647874 | |
| distemper studies in ferrets-part iii: iii. tissue vaccines prepared from neurotropic distemper virus. | 1942 | 17647880 | |
| distemper studies in ferrets-part iv: iv.protective, therapeutic and aggressin properties of composite tissue vaccine. | 1942 | 17647889 | |
| distemper studies in ferrets - part v: v. immunizing and therapeutic properties of anti-distemper serum. | 1942 | 17647897 | |
| distemper studies in ferrets-part vi: vi. attempted control of a distem per epidemic in a ferret colony with tissue va ccines and with anti-serum. | 1942 | 17647908 | |
| distemper studies in foxes: i. the experimental inoculation of foxes with formalized tissue of infected and of healthy ferrets during an epizootic. | 1943 | 17647958 | |
| distemper studies in foxes: iii. the cross immunizing properties of homologous and heterologous tissue vaccines against experimental distemper of foxes and ferrets. | 1943 | 17647985 | |
| distemper studies in foxes: vi. - attempted immunization of foxes with ferret distemper virus against canine distemper virus. | 1944 | 17648011 | |
| distemper studies in foxes: vii. the association of lymphocytic chroriomeningitis and ferret distemper viruses in experimental fox distemper. | 1944 | 17648018 | |
| leucopenia before ferret distemper. | 1945 | 17648127 |