Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| outbreak of colistin-resistant, carbapenemase-producing klebsiella pneumoniae: are we at the end of the road? | carbapenem-resistant klebsiella pneumoniae strains that produce k. pneumoniae carbapenemase (kpc) have spread globally in the last decade. colistin is a key agent in treating infections caused by this pathogen. in this issue of the journal of clinical microbiology, giani et al. (t. giani, f. arena, g. vaggelli, v. conte, a chiarell, l. h. de angelis, r. fornaini, m. grazzini, f. niccolini, p. pecile, and g. m. rossolini, j clin microbiol 53:3341-3344, 2015, http://dx.doi.org/10.1128/jcm.01017-15 ... | 2015 | 26202122 |
| large nosocomial outbreak of colistin-resistant, carbapenemase-producing klebsiella pneumoniae traced to clonal expansion of an mgrb deletion mutant. | we describe a large hospital outbreak (93 bloodstream infections) of colistin-resistant klebsiella pneumoniae carbapenemase (kpc)-producing k. pneumoniae isolates which was mirrored by increased colistin consumption. the outbreak was mostly traced to the clonal expansion of an mgrb deletion mutant of an st512 strain that produced kpc-3. | 2015 | 26202124 |
| clinical outcomes of spontaneous bacterial peritonitis due to extended-spectrum beta-lactamase-producing escherichia coli or klebsiella pneumoniae: a retrospective cohort study. | the aim of this study was to (1) evaluate the clinical outcomes of spontaneous bacterial peritonitis (sbp) due to extended-spectrum beta-lactamase (esbl)-producing escherichia coli or klebsiella pneumoniae (ek) and (2) investigate the relationship between the adequacy of initial antibiotic treatments and patient outcomes. | 2014 | 26202763 |
| complete genome sequence of endophytic nitrogen-fixing klebsiella variicola strain dx120e. | klebsiella variicola strain dx120e (=cgmcc 1.14935) is an endophytic nitrogen-fixing bacterium isolated from sugarcane crops grown in guangxi, china and promotes sugarcane growth. here we summarize the features of the strain dx120e and describe its complete genome sequence. the genome contains one circular chromosome and two plasmids, and contains 5,718,434 nucleotides with 57.1% gc content, 5,172 protein-coding genes, 25 rrna genes, 87 trna genes, 7 ncrna genes, 25 pseudo genes, and 2 crispr re ... | 2015 | 26203334 |
| molecular analysis of antibiotic resistance determinants and plasmids in malaysian isolates of multidrug resistant klebsiella pneumoniae. | infections caused by multidrug resistant klebsiella pneumoniae have been increasingly reported in many parts of the world. a total of 93 malaysian multidrug resistant k. pneumoniae isolated from patients attending to university of malaya medical center, kuala lumpur, malaysia from 2010-2012 were investigated for antibiotic resistance determinants including extended-spectrum beta-lactamases (esbls), aminoglycoside and trimethoprim/sulfamethoxazole resistance genes and plasmid replicons. ctx-m-15 ... | 2015 | 26203651 |
| genome sequence of klebsiella pneumoniae yzusk-4, a bacterium proposed as a starter culture for fermented meat products. | klebsiella pneumoniae strain yzusk-4, isolated from chinese rugao ham, is an efficient branched-chain aminotransferase-producing bacterium that can be used widely in fermented meat products to enhance flavor. the draft genome sequence of strain yzusk-4 may provide useful genetic information on branched-chain amino acid aminotransferase production and branched-chain amino acid metabolism. | 2015 | 26205853 |
| genome sequence of klebsiella pneumoniae cicc10011, a promising strain for high 2,3-butanediol production. | klebsiella pneumoniae cicc10011, a promising 2,3-butanediol producer, has received much attention because of its high productivity. here, the first draft genome sequence of this efficient strain may provide the genetic basis for further insights into the metabolic and regulatory mechanisms underlying the production of 2,3-butanediol at a high titer. | 2015 | 26205860 |
| editorial commentary: genomic epidemiology: revealing hidden reservoirs for klebsiella pneumoniae. | 2015 | 26206846 | |
| intermingled klebsiella pneumoniae populations between retail meats and human urinary tract infections. | klebsiella pneumoniae is a common colonizer of the gastrointestinal tract of humans, companion animals, and livestock. to better understand potential contributions of foodborne k. pneumoniae to human clinical infections, we compared k. pneumoniae isolates from retail meat products and human clinical specimens to assess their similarity based on antibiotic resistance, genetic relatedness, and virulence. | 2015 | 26206847 |
| genotypes of ciprofloxacin-resistant klebsiella pneumoniae in korea and their characteristics according to the genetic lineages. | we investigated the molecular genotypes of ciprofloxacin-resistant klebsiella pneumoniae and their characteristics according to the genetic lineages. for 160 k. pneumoniae collected in 2013, ciprofloxacin minimum inhibitory concentrations (mics) were determined by agar dilution method. the genotypes of ciprofloxacin-resistant k. pneumoniae isolates were determined by multilocus sequence typing (mlst) and wzi gene typing. the presence of plasmid-mediated resistance determinants [qnra, qnrb, qnrs, ... | 2015 | 26207318 |
| trends in susceptibility rates and extended-spectrum β-lactamase production of klebsiella pneumoniae in bloodstream infections across the united states veterans affairs healthcare system. | klebsiella pneumoniae is an important pathogen, increasingly notorious for its ability to become resistant to antimicrobial agents. this study sought to characterize trends in antimicrobial susceptibility rates for k. pneumoniae causing bacteremias across the united states (u.s.) veterans healthcare administration (vha) from 2007 through 2013 utilizing a national clinical database. k. pneumoniae grew in 9,235 blood cultures from 8,414 patients. nationally, ampicillin-sulbactam, ceftazidime, cefe ... | 2015 | 26207392 |
| colonization with resistant microorganisms in patients transferred from abroad: who needs to be screened? | while multi-drug resistant organisms (mdro) are a global phenomenon, there are significant regional differences in terms of prevalence. traveling to countries with a high mdro prevalence increases the risk of acquiring such an organism. in this study we determined risk factors for mdro colonization among patients who returned from a healthcare system in a high-prevalence area (so-called transfer patients). factors predicting colonization could serve as screening criteria to better target those a ... | 2015 | 26213620 |
| use of colistin-containing products within the european union and european economic area (eu/eea): development of resistance in animals and possible impact on human and animal health. | since its introduction in the 1950s, colistin has been used mainly as a topical treatment in human medicine owing to its toxicity when given systemically. sixty years later, colistin is being used as a last-resort drug to treat infections caused by multidrug-resistant (mdr) pseudomonas aeruginosa, acinetobacter baumannii and enterobacteriaceae (e.g., escherichia coli, klebsiella pneumoniae), for which mortality can be high. in veterinary medicine, colistin has been used for decades for the treat ... | 2015 | 26215780 |
| in vitro synergistic effect of the cm11 antimicrobial peptide in combination with common antibiotics against clinical isolates of six species of multidrug-resistant pathogenic bacteria. | during the last decades, increase of antibiotic resistance among pathogenic bacteria has been considered as a global concern. therefore, it is important to find new antimicrobial agents and/or therapeutic strategies. in previous studies we investigated antibacterial activity of the cm11 peptide against multiple drug resistant clinical isolates of six bacteria species including pseudomonas aeruginosa, staphylococcus aureus, acinetobacter baumannii, escherichia coli, klebsiella pneumoniae and salm ... | 2015 | 26216264 |
| mrjp1-containing glycoproteins isolated from honey, a novel antibacterial drug candidate with broad spectrum activity against multi-drug resistant clinical isolates. | the emergence of extended- spectrum β-lactamase (esbl) is the underlying cause of growing antibiotic resistance among gram-negative bacteria to β-lactam antibiotics. we recently reported the discovery of honey glycoproteins (glps) that exhibited a rapid, concentration-dependent antibacterial activity against both gram-positive bacillus subtilis and gram-negative escherichia coli that resembled action of cell wall-active β-lactam drugs. glps showed sequence identity with the major royal jelly pro ... | 2015 | 26217333 |
| low-level antimicrobial resistance of enterobacteriaceae isolated from the nares of pig-exposed persons. | extended-spectrum β-lactamase (esbl)-producing enterobacteriaceae (esbl-e) have recently emerged in livestock and humans. therefore, this study assessed the carriage of enterobacteriaceae in the anterior nares and associated antimicrobial resistance in pig-exposed persons. nasal swabs were enriched in non-selective broth and then plated on macconkey and esbl-selective agars. species was confirmed by matrix-assisted laser-desorption ionization-time-of-flight mass spectrometry (maldi-tof ms). anti ... | 2016 | 26219671 |
| evaluation of cefazolin as a surrogate marker for cefpodoxime susceptibility for urinary tract isolates. | of the cephalosporins, cefpodoxime has the most published clinical data for the treatment of urinary tract infections. in 2014, the clinical and laboratory standards institute (clsi) guidelines recommended that cefazolin should be used as the surrogate marker for cefpodoxime among urinary tract isolates, replacing cephalothin. this study attempted to determine how well cefazolin serves as the surrogate marker. additionally, it investigated how cefuroxime compared with cefazolin as a surrogate ma ... | 2015 | 26219948 |
| bacteria etiological agents causing lower respiratory tract infections and their resistance patterns. | lower respiratory tract infections (ltris) are among the most common infectious diseases with potential life-threatening complications. | 2015 | 26220641 |
| genomically informed surveillance for carbapenem-resistant enterobacteriaceae in a health care system. | carbapenem-resistant enterobacteriaceae (cre) are an urgent public health concern. rapid identification of the resistance genes, their mobilization capacity, and strains carrying them is essential to direct hospital resources to prevent spread and improve patient outcomes. whole-genome sequencing allows refined tracking of both chromosomal traits and associated mobile genetic elements that harbor resistance genes. to enhance surveillance of cres, clinical isolates with phenotypic resistance to c ... | 2015 | 26220969 |
| leukocyte presence does not increase microbicidal activity of platelet-rich plasma in vitro. | human platelets are a rich reservoir of molecules that promote regenerative processes and microbicidal activity. this activity might be increased by concentration in platelet-rich plasma (prp) products and modulated by the presence of leukocytes. despite extensive use in clinical procedures, only few studies have investigated prp's real microbicidal potential. therefore, this study aimed at comparing the in vitro microbicidal activity of platelets and leukocyte-enriched prp (l-prp) to pure plate ... | 2015 | 26223356 |
| phoenix dactylifera (date palm) pit aqueous extract mediated novel route for synthesis high stable silver nanoparticles with high antifungal and antibacterial activity. | the biological synthesis of silver nanoparticles (agnps) was conducted using date palm pit aqueous extract. the first visible sign of the synthesis of agnps was the change in colour of reaction mixtures from yellowish to reddish brown. the resulting synthesised agnps were characterised using uv-visible spectroscopy, x-ray diffraction (xrd), transmission electron microscopy (tem) and dynamic light scattering (dls). the uv-visible spectra gave surface plasmon resonance at 428 nm. xrd confirmed tha ... | 2015 | 26224347 |
| allocation of klebsiella pneumoniae bloodstream isolates into four distinct groups by ompk36 typing in a taiwanese university hospital. | the ompk36 porin plays a role in carbapenem resistance and may contribute to bacterial virulence in klebsiella pneumoniae. this study aimed to investigate the characteristics of different groups of k. pneumoniae separated by ompk36 typing. among 226 nonduplicate k. pneumoniae bloodstream isolates collected at a taiwanese hospital in 2011, four ompk36 types, designated types a, b, c, and d, were identified by pcr in 61, 28, 100, and 36 isolates, respectively; 1 isolate was untypeable. statistical ... | 2015 | 26224840 |
| molecular typing of enterobacteriaceae from pig holdings in north-western germany reveals extended- spectrum and ampc β-lactamases producing but no carbapenem resistant ones. | the increase of extended- spectrum β-lactamase-producing enterobacteriaceae (esbl-e) in humans and in food-producing animals is of public health concern. the latter could contribute to spreading of these bacteria or their resistance genes to humans. several studies have reported the isolation of third generation cephalosporin resistant bacteria in livestock animals. however, the number of samples and the methodology used differ considerably between studies limiting comparability and prevalence a ... | 2015 | 26225428 |
| antimicrobial resistance of bacterial isolates from respiratory secretions of ventilated patients in a multi-specialty hospital. | ventilator-associated pneumonia (vap) is a common nosocomial infection occurring in intensive care unit (icu) settings. vap occurs due to interplay of three factors - impaired host defense, access of large numbers of pathogenic bacteria to the lower respiratory tract and the virulence of the organism. knowledge of colonizing microbial flora and their antibiogram in ventilated patients is of great importance in timely institution of empirical therapy, so that mortality and morbidity due to vap ca ... | 2017 | 26229758 |
| quinoxaline based bio-active mixed ligand transition metal complexes: synthesis, characterization, electrochemical, antimicrobial, dna binding, cleavage, antioxidant and molecular docking studies. | co(ii), ni(ii), cu(ii) and zn(ii) mixed ligand complexes have been synthesized from n(2), n(3)-bis(4-nitrophenyl)quinoxaline-2,3-diamine and 1,10-phenanthroline. the compounds were characterized by elemental analyses, molar conductance, magnetic susceptibility, ir, uv-vis., (1)h nmr, mass and esr spectra. octahedral geometry has been assigned for co(ii), ni(ii) and zn(ii) complexes and distorted octahedral geometry for cu(ii) complex. electrochemical behavior of the synthesized complexes was stu ... | 2015 | 26232747 |
| comparative analysis of virulence determinants, antibiotic susceptibility patterns and serogrouping of atypical enteropathogenic escherichia coli versus typical enteropathogenic e. coli in india. | the epidemiology of enteropathogenic escherichia coli (epec) and the significance of isolation of atypical epec (aepec) in childhood diarrhoea have not been well studied in an indian context. a comparative study was undertaken to investigate virulence determinants, antibiotic susceptibility patterns and serogrouping of typical epec (tepec) versus aepec causing diarrhoea in children. a total of 400 prospective and 500 retrospective e. coli isolates were included. pcr was performed for eae, bfpa, ... | 2015 | 26233663 |
| vector promoters used in klebsiella pneumoniae. | much effort has been devoted to the metabolic engineering of klebsiella pneumoniae; however, our knowledge of the actual expression level of promoters used in k. pneumoniae is limited. in this study, the expression levels of three promoters were compared systematically by using the lacz reporter gene with different carbon sources in k. pneumoniae. the results showed that, although promoters pt5 and ptac designed for escherichia coli were functional, pt5 appeared more efficient and the induction/ ... | 2016 | 26234465 |
| urinary tract infections in kidney transplant patients due to escherichia coli and klebsiella pneumoniae-producing extended-spectrum β-lactamases: risk factors and molecular epidemiology. | urinary tract infection (uti) is a common complication after kidney transplantation, often associated to graft loss and increased healthcare costs. kidney transplant patients (ktps) are particularly susceptible to infection by enterobacteriaceae-producing extended-spectrum β-lactamases (esbls). a retrospective case-control study was conducted to identify independent risk factors for esbl-producing escherichia coli and klebsiella pneumoniae in non-hospitalized ktps with uti. forty-nine patients s ... | 2015 | 26237422 |
| intravenous fosfomycin treatment for carbapenem-resistant klebsiella pneumoniae in the united states. | 2015 | 26238469 | |
| survey of clustered regularly interspaced short palindromic repeats and their associated cas proteins (crispr/cas) systems in multiple sequenced strains of klebsiella pneumoniae. | in recent years the emergence of multidrug resistant klebsiella pneumoniae strains has been an increasingly common event. this opportunistic species is one of the five main bacterial pathogens that cause hospital infections worldwide and multidrug resistance has been associated with the presence of high molecular weight plasmids. plasmids are generally acquired through horizontal transfer and therefore is possible that systems that prevent the entry of foreign genetic material are inactive or ab ... | 2015 | 26238567 |
| 16s rdna pcr-dgge and sequencing in the diagnosis of neonatal late-onset septicemia. | the 16s rdna polymerase chain reaction (pcr)-denaturing gradient gel electrophoresis (dgge) and sequencing method has been demonstrated to be valuable in detecting pathogens in the blood of patients suffering from fever or neutropenia. however, its use in the diagnosis of neonatal late‑onset septicemia (los) has not yet been reported. the aim of the present study was to investigate the efficiency of this method in detection of the type of bacterial infection in neonatal los. blood specimens from ... | 2015 | 26238862 |
| emergence of concurrent infections with colistin-resistant esbl-positive klebsiella pneumoniae and oxa-23-producing acinetobacter baumannii sensitive to colistin only in a romanian cardiac intensive care unit. | we report the emergence and analysis of a cluster of concurrent infections/colonisations with colistin-resistant klebsiella pneumoniae and oxa-23 carbapenemase-producing acinetobacter baumannii in patients who had undergone cardiac surgery. we describe the emergence of colistin-resistant k. pneumoniae harbouring blactx-m-15, blashv-11, blaoxa-1, blatem-1 beta-lactamases and aac(6')-ib-cr fluoroquinolone resistance. colistin-resistant k. pneumoniae infections (pneumonia, wound infection, urinary ... | 2015 | 26239064 |
| inactivation of the virulence factors from 2,3-butanediol-producing klebsiella pneumoniae. | the microbiological production of 2,3-butanediol (2,3-bdo) has attracted considerable attention as an alternative way to produce high-value chemicals from renewable sources. among the number of 2,3-bdo-producing microorganisms, klebsiella pneumoniae has been studied most extensively and is known to produce large quantity of 2,3-bdo from a range of substrates. on the other hand, the pathogenic characteristics of the bacteria have limited its industrial applications. in this study, two major virul ... | 2015 | 26239074 |
| evaluation of gallium citrate formulations against a multidrug-resistant strain of klebsiella pneumoniae in a murine wound model of infection. | skin and soft tissue infections (sstis) are a common occurrence in health care facilities with a heightened risk for immunocompromised patients. klebsiella pneumoniae has been increasingly implicated as the bacterial agent responsible for sstis, and treatment can be challenging as more strains become multidrug resistant (mdr). therefore, new treatments are needed to counter this bacterial pathogen. gallium complexes exhibit antimicrobial activity and are currently being evaluated as potential tr ... | 2015 | 26239978 |
| production of a modified peptide clavanin in pichia pastoris: cloning, expression, purification and in vitro activities. | antimicrobial peptides are one of the most promising peptide-based drugs due to their enormous potential as novel biopharmaceuticals in both human and animal industries. in order to develop strategies to over produce such molecules, heterologous production of a modified version of clavanin a, here named clavanin mo (clavmo), was successfully achieved in the methylothopic yeast pichia pastoris. clavmo was fused to thioredoxin as a carrier protein and the construction was tested using two promoter ... | 2015 | 26243173 |
| synthesis, antibacterial and qsar evaluation of 5-oxo and 5-thio derivatives of 1,4-disubstituted tetrazoles. | a series of 1,4-disubstituted tetrazol-5-ones 3a, 5, 7, 12, 13 and 1,4-disubstituted tetrazol-5-thiones 3b, 9, 10 was synthesized and fully characterized by ir, ms, (1)h nmr and (13)c nmr. the series was evaluated for in vitro antibacterial activity against four gram negative (escherichia coli, proteus mirabilis, klebsiella pneumonia, and pseudomonas aeruginosa) and three gram positive (staphylococcus aureus, enterococcus faecalis, and bacillus subtilis) bacteria. the zone of inhibition was meas ... | 2015 | 26243367 |
| carbapenem-resistant enterobacteriaceae: a case series of infections at hartford hospital. | infections due to carbapenem-resistant enterobacteriaceae (cre) represent a growing problem nationally, are difficult to treat, and are associated with high mortality rates. features of cre infection within connecticut, a nonendemic area, have not been described in the medical literature. we report a case series of five patients with cre isolates who were treated at hartford hospital in hartford, connecticut from 2011-2013. cre isolates included three klebsiella pneumoniae, one klebsiella oxytoc ... | 2015 | 26245014 |
| reparixin attenuates neuronal injury in experimental klebsiella pneumoniae meningoencephalitis through dual effects on neuroprotection and neuroinflammation. | bacterial meningitis causes high mortality and brain damage. the host immune response is associated with brain injury. chemokine (c-x-c motif) (cxc) chemokines are neutrophil chemoattractants. this study focused on the beneficial effects of intracerebroventricular administration of reparixin, an inhibitor of chemokine (c-x-c motif) receptor (cxcr)1/2, to rats at 2 h following experimental klebsiella pneumoniae meningoencephalitis. | 2016 | 26245311 |
| antibacterial activity of ethanolic extract and compounds from fruits of tectona grandis (verbenaceae). | well known as teak, tectona grandis is widely used in african folk medicine for its pharmacological relevance. in cameroon, this species is a reputed laxative in the northern region while in the western region, it is used in the treatment of skin diseases and diarrhoea. | 2015 | 26245866 |
| klebsiella pneumoniae subsp. pneumoniae-bacteriophage combination from the caecal effluent of a healthy woman. | a sample of caecal effluent was obtained from a female patient who had undergone a routine colonoscopic examination. bacteria were isolated anaerobically from the sample, and screened against the remaining filtered caecal effluent in an attempt to isolate bacteriophages (phages). a lytic phage, named klpn1, was isolated on a strain identified as klebsiella pneumoniae subsp. pneumoniae (capsular type k2, rmpa (+)). this siphoviridae phage presents a rosette-like tail tip and exhibits depolymerase ... | 2015 | 26246963 |
| structural and adhesive properties of the long polar fimbriae protein lpfd from adherent-invasive escherichia coli. | crohn's disease (cd) is an inflammatory bowel disease characterized by an exaggerated immune response to commensal microbiota in the intestines of patients. metagenomic studies have identified specific bacterial species and strains with increased prevalence in cd patients, amongst which is the adherent-invasive escherichia coli (aiec) strain lf82. aiec strains express long polar fimbriae (lpf), which are known to target peyer's patches in a mouse cd model. here, the recombinant production of a s ... | 2015 | 26249343 |
| biocide immobilized ommt-carbon dot reduced cu2o nanohybrid/hyperbranched epoxy nanocomposites: mechanical, thermal, antimicrobial and optical properties. | the present work demonstrated a transparent thermosetting nanocomposite with antimicrobial and photoluminescence attributes. the nanocomposites are fabricated by incorporation of different wt.% (1, 2 and 3) of a biocide immobilized ommt-carbon dot reduced cu2o nanohybrid (mith-nh) in the hyperbranched epoxy matrix. mith-nh is obtained by immobilization of 2-methyl-4-isothiazolin-3-one hydrochloride (mith) at room temperature using sonication on ommt-carbon dot reduced cu2o nanohybid. the nanohyb ... | 2015 | 26249567 |
| microbiologic characteristics and predictors of mortality in bloodstream infections in intensive care unit patients: a 1-year, large, prospective surveillance study in 5 italian hospitals. | bloodstream infections (bsis) from multidrug-resistant (mdr) bacteria cause morbidity and mortality in intensive care unit (icu) patients worldwide. this study investigated the incidence of bsis in 5 adult general icus in rome, italy, and evaluated the mortality rate and risk factors associated with these infections. | 2015 | 26253805 |
| prevalence of bovine subclinical mastitis, its etiology and diagnosis of antibiotic resistance of dairy farms in four municipalities of a tropical region of mexico. | a region-wide survey was conducted in the tropical area of tierra caliente, state of guerrero, mexico to estimate the prevalence of subclinical bovine mastitis (scm), distribution of mastitis pathogens, and in vitro antimicrobial susceptibility of different mastitis pathogens in dairy farms. in total, 1036 quarter milk samples were obtained from 259 cows at 87 different dairy farms. collected quarter milk samples were submitted for california mastitis test (cmt), bacteriological examination, and ... | 2015 | 26255183 |
| viruses and gram-negative bacilli dominate the etiology of community-acquired pneumonia in indonesia, a cohort study. | knowledge about the etiology of community-acquired pneumonia (cap) is essential for adequate management. presently, few studies about cap are available from southeast asia. this study aimed to investigate the etiology, severity, and outcome of cap in the most populous southeast asia country, indonesia. | 2015 | 26255889 |
| cefepime combined with amoxicillin/clavulanic acid: a new choice for the kpc-producing k. pneumoniae infection. | clinical treatment for blakpc-positive klebsiella pneumoniae isolates is challenging because the recommended antibiotic options are limited and are extraordinarily expensive. this study aimed to explore a new therapy for infection caused by kpc-producing k. pneumoniae. | 2015 | 26255892 |
| macrocyclic peptidomimetics with antimicrobial activity: synthesis, bioassay, and molecular modeling studies. | novel, cyclic peptidomimetics were synthesized by facile acylation reactions using benzotriazole chemistry. microbiological testing of the synthesized compounds revealed an exceptionally high activity against candida albicans with a minimum inhibitory concentration (mic) two orders of magnitude lower than the mic of the antifungal reference drug amphotericin b. a strikingly high activity was also observed against three gram-negative bacterial strains (pseudomonas aeruginosa, klebsiella pneumonia ... | 2015 | 26256838 |
| first report of two rapid-onset fatal infections caused by a newly emerging hypervirulent k. pneumonia st86 strain of serotype k2 in china. | here, we present the first report of one suspected dead case and two confirmed rapid-onset fatal infections caused by a newly emerging hypervirulent klebsiella pneumoniae st86 strain of serotype k2. the three cases occurred in a surgery ward during 2013 in shanghai, china. a combination of multilocus sequence typing, pulsed-field gel electrophoresis, phenotypic and pcr tests for detecting virulence factors (vfs) was used to identify the isolates as k2 st86 strains with common vfs, including aero ... | 2015 | 26257712 |
| streptococcus gallolyticus (bovis): a rare presentation of meningitis in the ed. | bacterial meningitis is a fairly common and often deadly manifestation of altered mental status in the elderly, carrying a mortality rate of greater than 20% despite antibiotic therapy. most commonly caused by streptococcus pneumoniae, listeria monocytogenes, escherichia coli, and klebsiella pneumoniae. we present a case of meningitis caused by streptococcus gallolyticus in an elderly, otherwise healthy woman. there have been no reports in the emergency medicine literature and only a few reports ... | 2016 | 26259921 |
| deep transcriptome profiling of clinical klebsiella pneumoniae isolates reveals strain and sequence type-specific adaptation. | health-care-associated infections by multi-drug-resistant bacteria constitute one of the greatest challenges to modern medicine. bacterial pathogens devise various mechanisms to withstand the activity of a wide range of antimicrobial compounds, among which the acquisition of carbapenemases is one of the most concerning. in klebsiella pneumoniae, the dissemination of the k. pneumoniae carbapenemase is tightly connected to the global spread of certain clonal lineages. although antibiotic resistanc ... | 2015 | 26261087 |
| new antibiotics and antimicrobial combination therapy for the treatment of gram-negative bacterial infections. | increasing rates of life-threatening infections due to multidrug-resistant (mdr) gram-negative bacteria, such as carbapenemase-producer strains, as well as pathogens that are resistant to all current therapeutic options, have been reported. the number of compounds that are currently being developed is still insufficient to control this global threat. we have reviewed the current available options for the treatment of mdr gram-negative infections, including combination regimens employing older an ... | 2015 | 26263298 |
| two cases of klebsiella pneumoniae liver abscess necessitating liver resection for effective treatment. | we report two british cases of liver abscess, due to klebsiella pneumoniae and associated with synchronous infection elsewhere, which required liver resection for definitive treatment. they illustrate the geographic spread of aggressive k pneumoniae liver infection and demonstrate the importance of early aggressive treatment. | 2015 | 26263824 |
| pediatric emphysematous cystitis: a report and review of a rare diagnosis in children. | an 11-year-old female with spastic quadriplegia was seen in the emergency room with abdominal pain, vomiting and anorexia. labs revealed possible pancreatitis and signs of a urinary tract infection. a ct scan was performed to assess her abdominal pain and demonstrated circumferential air within the bladder wall. following cultures being drawn, she was started on broad spectrum antibiotics. her urine eventually grew klebsiella pneumoniae. follow up imaging 2 weeks later demonstrated resolution of ... | 2015 | 26267032 |
| clinical and microbiologic characteristics of adult patients with recurrent bacteraemia caused by extended-spectrum β-lactamase-producing escherichia coli or klebsiella pneumoniae. | the characteristics of patients with recurrent bacteraemia caused by extended-spectrum β-lactamase (esbl)-producing escherichia coli or klebsiella pneumoniae (ek) are rarely described. flomoxef belongs to the cephamycins group and demonstrates in vitro activity against esbl-producing organisms. whether flomoxef may be used for the treatment of such infections remains controversial. this retrospective case-control study enrolled adult patients who had bacteraemia caused by esbl-ek during 2005-201 ... | 2015 | 26271718 |
| complete genome sequence of phytopathogenic pectobacterium atrosepticum bacteriophage peat1. | pectobacterium atrosepticum is a common phytopathogen causing significant economic losses worldwide. to develop a biocontrol strategy for this blackleg pathogen of solanaceous plants, p. atrosepticum bacteriophage peat1 was isolated and its genome completely sequenced. interestingly, morphological and sequence analyses of the 45,633-bp genome revealed that phage peat1 is a member of the family podoviridae and most closely resembles the klebsiella pneumoniae bacteriophage kp34. this is the first ... | 2015 | 26272557 |
| kpc-2-producing klebsiella pneumoniae in a hospital in the midwest region of brazil. | the emergence of β-lactamase-producing enterobacteriaceae in the last few decades has become major challenge faced by hospitals. in this study, isolates of klebsiella pneumoniae carbapenemase-2 (kpc-2)-producing k. pneumoniae from a tertiary hospital in mato grosso do sul, brazil, were characterized. bacterial identification was performed by matrix-assisted laser desorption/ionization time-of-flight (maldi-tof; bruker daltonics, germany) mass spectrometry. the minimum inhibitory concentrations o ... | 2015 | 26273265 |
| risk factors for bloodstream infections due to colistin-resistant kpc-producing klebsiella pneumoniae: results from a multicenter case-control-control study. | the increasing prevalence of colistin resistance (colr) klebsiella pneumoniae carbapenemase (kpc)-producing k. pneumoniae (kp) is a matter of concern because of its unfavourable impact on mortality of kpc-kp bloodstream infections (bsi) and the shortage of alternative therapeutic options. a matched case-control-control analysis was conducted. the primary study end point was to assess risk factors for colr kpc-kp bsi. the secondary end point was to describe mortality and clinical characteristics ... | 2015 | 26278669 |
| lemierre's syndrome caused by klebsiella pneumoniae in a diabetic patient: a case report and review of the literature. | lemierre's syndrome is characterized by an oropharyngeal infection with internal jugular vein thrombosis followed by metastatic infections in other organs. this infection is usually caused by fusobacterium spp. in this report, we present a rare case of klebsiella pneumoniae-associated lemierre's syndrome in a patient with poorly-controlled diabetes mellitus. the infection was complicated by septic emboli in many organs, which led to the patient's death, despite combined antibiotics, anticoagulan ... | 2015 | 26279962 |
| s argassum muticum-synthesized silver nanoparticles: an effective control tool against mosquito vectors and bacterial pathogens. | mosquito-borne diseases represent a deadly threat for millions of people worldwide. furthermore, pathogens and parasites polluting water also constitute a severe plague for populations of developing countries. in this research, silver nanoparticles (agnp) were synthesized using the aqueous extract of the seaweed sargassum muticum. the production of agnp was confirmed by surface plasmon resonance band illustrated in uv-vis spectrophotometry. agnp were characterized by ftir, sem, edx, and xrd anal ... | 2015 | 26281786 |
| loss of hypermucoviscosity and increased fitness cost in colistin-resistant klebsiella pneumoniae sequence type 23 strains. | in this study, we investigated the effects of colistin resistance on virulence and fitness in hypermucoviscous (hv) klebsiella pneumoniae sequence type 23 (st23) strains. colistin-resistant mutants were developed from three colistin-susceptible hv k. pneumoniae st23 strains. the lipid a structures of strains were analyzed by matrix-assisted laser desorption ionization-time of flight (maldi-tof) mass spectrometry. changes in hv were investigated using the string test, and extracellular polysaccha ... | 2015 | 26282408 |
| outbreak caused by enterobacteriaceae harboring ndm-1 metallo-β-lactamase carried in an incfii plasmid in a tertiary care hospital in mexico city. | carbapenem-resistant enterobacteriaceae carrying new delhi metallo-β-lactamase 1 (ndm-1) have rarely been reported in latin america. we report of an outbreak caused by a blandm-1-harboring plasmid spread through different bacterial species, including escherichia coli (st617) and enterobacter cloacae (st182) isolates from the same patient and three klebsiella pneumoniae isolates (st22) derived from three epidemiologically related patients. incfii plasmids were found in all strains. measures to co ... | 2015 | 26282410 |
| emergence of raoultella ornithinolytica coproducing imp-4 and kpc-2 carbapenemases in china. | we report here the emergence of seven imp-4-producing raoultella ornithinolytica isolates obtained from one patient. all isolates carried the blaimp-4 carbapenemase gene, five isolates also carried blashv-12, four contained blatem-1, and one contained blaoxa-1. notably, the r. ornithinolytica isolate ro25724 also expressed klebsiella pneumoniae carbapenemase (kpc)-2. the blakpc-2 gene was located on a tn3-tn4401 integration structure on a plasmid of ∼450 kb. this is the first description of the ... | 2015 | 26282422 |
| antimicrobial activity and the presence of virulence factors and bacteriocin structural genes in enterococcus faecium cm33 isolated from ewe colostrum. | screening of lactic acid bacteria (lab) isolated from ewe colostrum led to the identification and isolation of enterococcus faecium cm33 with interesting features like high survival rates under acidic or bile salts condition, high tolerance for the simulated gastrointestinal condition, and high adhesive potential to caco-2 cells. according the inhibition of pathogen adhesion test results, this strain can reduce more than 50% adhesion capacity of escherichia coli, shigella flexneri, klebsiella pn ... | 2015 | 26284059 |
| prevalence and characterization of carbapenem-resistant enterobacteriaceae isolated from mulago national referral hospital, uganda. | carbapenemases have increasingly been reported in enterobacteriaceae worldwide. most carbapenemases are plasmid encoded hence resistance can easily spread. carbapenem-resistant enterobacteriaceae are reported to cause mortality in up to 50% of patients who acquire bloodstream infections. we set out to determine the burden of carbapenem resistance as well as establish genes encoding for carbapenemases in enterobacteriaceae clinical isolates obtained from mulago national referral hospital, uganda. | 2015 | 26284519 |
| quantitative analysis of pathogens in the lower respiratory tract of patients with chronic obstructive pulmonary disease. | bacterial infection of the lower respiratory tract is believed to play a major role in the pathogenesis of chronic obstructive pulmonary disease (copd) and acute exacerbations of copd (aecopd). this study investigates the potential relationship between aecopd and the load of six common bacterial pathogens in the lower respiratory tract using real-time quantitative pcr (rt-qpcr) in copd patients. | 2015 | 26286268 |
| therapy of liver abscesses. | liver abscess (la) is an uncommon but potentially life-threatening disease with significant morbidity and mortality. | 2014 | 26287275 |
| efficacy of appropriate antimicrobial therapy on the survival of patients with carbapenem nonsusceptible klebsiella pneumoniae infection: a multicenter study in taiwan. | the impact of antimicrobial treatment on the outcome of carbapenem nonsusceptible klebsiella pneumoniae (cnskp) infections needs to be elucidated. this nationwide, multicenter study was conducted to evaluate the impact of appropriate antimicrobial therapy on 14-day mortality among patients with cnskp infection in taiwan.patients with cnskp infections from 11 medical centers and 4 regional hospitals in taiwan were enrolled in 2013. carbapenem nonsusceptibility was defined as a minimum inhibitory ... | 2015 | 26287432 |
| azithromycin synergizes with cationic antimicrobial peptides to exert bactericidal and therapeutic activity against highly multidrug-resistant gram-negative bacterial pathogens. | antibiotic resistance poses an increasingly grave threat to the public health. of pressing concern, rapid spread of carbapenem-resistance among multidrug-resistant (mdr) gram-negative rods (gnr) is associated with few treatment options and high mortality rates. current antibiotic susceptibility testing guiding patient management is performed in a standardized manner, identifying minimum inhibitory concentrations (mic) in bacteriologic media, but ignoring host immune factors. lacking activity in ... | 2015 | 26288841 |
| the β-lactams strike back: ceftazidime-avibactam. | gram-negative resistance has reached a crucial point, with emergence of pathogens resistant to most or all available antibiotics. ceftazidime-avibactam is a newly approved agent combining ceftazidime and a novel β-lactamase inhibitor with activity against multidrug-resistant gram-negative bacteria. avibactam has increased potency and expanded spectrum of inhibition of class a and c β-lactamases relative to available β-lactamase inhibitors, including extended-spectrum β-lactamases, ampc, and kleb ... | 2015 | 26289307 |
| improved phenotype-based definition for identifying carbapenemase producers among carbapenem-resistant enterobacteriaceae. | preventing transmission of carbapenemase-producing, carbapenem-resistant enterobacteriaceae (cp-cre) is a public health priority. a phenotype-based definition that reliably identifies cp-cre while minimizing misclassification of non-cp-cre could help prevention efforts. to assess possible definitions, we evaluated enterobacterial isolates that had been tested and deemed nonsusceptible to >1 carbapenem at us emerging infections program sites. we determined the number of non-cp isolates that met ( ... | 2015 | 26290955 |
| in vitro activity of cefepime/aai101 and comparators against cefepime non-susceptible enterobacteriaceae. | we evaluated the in vitro potency of cefepime combined with aai101, a novel extended-spectrum β-lactamase inhibitor, against a population of clinical escherichia coli and klebsiella pneumoniae collected from usa hospitals. of the 223 cefepime non-susceptible isolates, 95% were ceftazidime non-susceptible, 49% ertapenem non-susceptible, 57% piperacillin/tazobactam non-susceptible, 90% were multidrug-resistant (resistant to ≥3 drug classes), 22% produced carbapenemases, and 67% produced esbls. add ... | 2015 | 26295262 |
| comparative whole genome transcriptome and metabolome analyses of five klebsiella pneumonia strains. | the integration of transcriptomics and metabolomics can provide precise information on gene-to-metabolite networks for identifying the function of novel genes. the goal of this study was to identify novel gene functions involved in 2,3-butanediol (2,3-bdo) biosynthesis by a comprehensive analysis of the transcriptome and metabolome of five mutated klebsiella pneumonia strains (∆wabg = sgsb100, ∆wabg∆buda = sgsb106, ∆wabg∆budb = sgsb107, ∆wabg∆budc = sgsb108, ∆wabg∆budabc = sgsb109). first, the t ... | 2015 | 26296382 |
| kidney transplant recipients infected with blakpc-2-producing klebsiella pneumoniae. | 2015 | 26299180 | |
| high prevalence and antimicrobial resistance of urinary tract infection isolates in febrile young children without localizing signs in taiwan. | antimicrobial susceptibility and prevalence of pediatric urinary tract infection (uti) is very useful for pediatricians in selecting effective antibiotics in time to improve outcomes in patients. this study aimed to determine the prevalence rate, bacterial distribution, and antimicrobial susceptibility of uti in febrile young children at a teaching hospital in northern taiwan. | 2016 | 26299351 |
| bloodstream infections in intensive care unit patients: distribution and antibiotic resistance of bacteria. | bloodstream infections (bsis) are among the leading infections in critically ill patients. the case-fatality rate associated with bsis in patients admitted to intensive care units (icus) reaches 35%-50%. the emergence and diffusion of bacteria with resistance to antibiotics is a global health problem. multidrug-resistant bacteria were detected in 50.7% of patients with bsis in a recently published international observational study, with methicillin resistance detected in 48% of staphylococcus au ... | 2015 | 26300651 |
| rapid detection of porins by matrix-assisted laser desorption/ionization-time of flight mass spectrometry. | the rapid and cost-efficient determination of carbapenem resistance is an important prerequisite for the choice of an adequate antibiotic therapy. a maldi-tof ms-based assay was set up to detect porins in the current study. a loss of the components of porin alone such as ompk35/ompk36 or together with the production of carbapenemases will augment the carbapenem resistance. ten strains of escherichia coli and eight strains of klebsiella pneumoniae were conducted for both sodium dodecylsulfate-pol ... | 2015 | 26300858 |
| prevalence of plasmid-mediated quinolone resistance determinants and oqxab efflux pumps among extended-spectrum β-lactamase producing klebsiella pneumoniae isolated from patients with nosocomial urinary tract infection in tehran, iran. | objective. plasmid-mediated quinolone resistance (pmqr) plays an important role in the development of clinical resistance to quinolone. the aim of this study was to investigate pmqr determinants among extended-spectrum β-lactamases- (esbl-) producing klebsiella pneumoniae recovered from patients with nosocomial urinary tract infection (uti). methods. a total of 247 esbl-producing k. pneumoniae isolates were collected from 750 patients with uti. esbl production was confirmed by double disc synerg ... | 2015 | 26301114 |
| structure-function relationships of class d carbapenemases. | class d carbapenemases, also known as carbapenem-hydrolyzing class d β-lactamases (chdls) are of increasingly high clinical relevance, as they have been found in various important human pathogens, such as acinetobacter baumannii and klebsiella pneumoniae and contribute to the evolution of these pathogens towards extensively or totally-drug resistance (xdr/tdr) phenotypes. essentially two main groups of phylogenetically-related enzymes have been described: one including the acquired oxa-23, oxa-2 ... | 2016 | 26302798 |
| broad spectrum antimicrobial compounds from the bacterium exiguobacterium mexicanum mssrfs9. | clinical bacterial pathogens front a major challenge for the clinical researchers and physicians. in particular microbial pathogens like escherichia coli, shigella flexneri, klebsiella pneumonia and salmonella enterica are apparelled with systemic machineries to bring down the human immune system as well as proliferate dramatically in a short period which in turn cause a pronounced ailment to the human health. in vitro evaluation of four purified compounds isolated from rhizosphere bacterium exi ... | 2015 | 26302848 |
| clonal dissemination of multilocus sequence type st15 kpc-2-producing klebsiella pneumoniae in bulgaria. | a total of 36 consecutive clinical and two fecal-screening carbapenem-resistant klebsiella pneumoniae isolates from two bulgarian university hospitals (varna and pleven) were investigated. susceptibility testing, conjugation experiments, and plasmid replicon typing were carried out. beta-lactamases were characterized by isoelectric focusing, pcr, and sequencing. clonal relatedness was investigated by rapd and multilocus sequence typing (mlst). most of the isolates demonstrated multidrug resistan ... | 2015 | 26303718 |
| acquisition of the lac operon by salmonella enterica. | classical bacteriological characteristics of salmonella enterica indicate that the members of this species are unable to utilize lactose as a carbon source. however, lactose-fermenting (lac+) strains of several salmonella serovars have been isolated from different foodborne outbreaks as well as different geographical regions worldwide. in the present study, we sequenced the genomes of 13 lac + s. enterica isolates and characterized the lac region, comparing it to the lac region in other enteric ... | 2015 | 26303940 |
| emergence of a hypervirulent carbapenem-resistant klebsiella pneumoniae isolate from clinical infections in china. | hypervirulent klebsiella pneumoniae (hvkp) infections occur worldwide, but carbapenem-resistant hvkp strain has rarely been observed. | 2015 | 26304687 |
| evaluating utility gloves as a potential reservoir for pathogenic bacteria. | this pilot study sought to determine the rate and degree to which gram-negative klebsiella pneumoniae, escherichia coli and pseudomonas aeruginosa and gram-positive staphylococcus aureus occurred on the inside of utility gloves used at university of maine at augusta, dental health programs' dental hygiene clinic. | 2015 | 26304950 |
| detection of klebsiella pneumoniae co-producing ndm-7 and oxa-181, escherichia coli producing ndm-5 and acinetobacter baumannii producing oxa-23 in a single patient. | 2015 | 26307465 | |
| a common flanking region in promiscuous plasmids encoding blandm-1 in klebsiella pneumoniae isolated in singapore. | bacteria encoding the new delhi metallo-β-lactamase gene (blandm-1) are regarded as superbugs for their resistance to multiple antibiotics. plasmids encoding blandm-1 have been observed to be spreading among gram-negative bacteria around the world. previous studies have demonstrated that multiple modifications of blandm-1-harboring plasmids might contribute to the spread of the gene. in this study, we analyzed blandm-1-encoding plasmids from two klebsiella pneumoniae isolates, du7433 and du1301, ... | 2016 | 26308279 |
| gradual increase in antibiotic concentration affects persistence of klebsiella pneumoniae. | sublethal bactericidal antibiotics promote the formation of multidrug-tolerant persisters. clinically, serum drug concentration increases gradually and reaches the peak level with high killing efficiency some time after administration. this study aimed to investigate if the initial low antibiotic concentration would promote persister formation in klebsiella pneumoniae, an increasingly important nosocomial pathogen. | 2015 | 26311842 |
| prevalence, risk factors, and transmission dynamics of extended-spectrum-β-lactamase-producing enterobacteriaceae: a national survey of cattle farms in israel in 2013. | our objectives were to study the prevalence, risk factors for carriage, and transmission dynamics of extended-spectrum-β-lactamase (esbl)-producing enterobacteriaceae (esblpe) in a national survey of cattle. this was a point prevalence study conducted from july to october 2013 in israel. stool samples were collected from 1,226 cows in 123 sections on 40 farms of all production types. esblpe were identified in 291 samples (23.7%): 287 contained escherichia coli and 4 contained klebsiella pneumoni ... | 2015 | 26311861 |
| antimicrobial susceptibility pattern of extended-spectrum beta- lactamase producing klebsiella pneumoniae clinical isolates in an indian tertiary hospital. | there is an increased prevalence of extended-spectrum beta-lactamase producing klebsiella pneumoniae (esbl-kp) worldwide including india, which is a major concern for the clinicians, especially in intensive care units and pediatric patients. this study aims to determine the prevalence of esbl-kp and antimicrobial sensitivity profile to plan a proper hospital infection control program to prevent the spread of resistant strains. | 2017 | 26312255 |
| diversity of the genetic environment of the blakpc-2 gene among klebsiella pneumoniae clinical isolates in a chinese hospital. | kpc-producing klebsiella pneumoniae (kpc-kp) has been frequently reported worldwide and constitutes a major healthcare threat, given their extensively drug-resistant phenotypes. in this study, we report the characterization of the genetic environment of blakpc-2 gene in kpc-kp clinical strains from china belonging to diverse genotypes. thirty-five nonduplicated kpc-kp isolates collected in a chinese hospital during 2012 were analyzed. all were multidrug resistant due to the presence of other res ... | 2016 | 26313117 |
| [using galleria mellonella as an in vivo model to study the virulence of some bacterial and fungal agents]. | non-vertebrate hosts, such as galleria mellonella, namely wax moth, have been used to study microbial virulence and host defense. this organism has advantages as it is economical, ethically expedient and easy to handle. here we describe an experimental in vivo study using the larvae of galleria mellonella infected with some bacterial and fungal pathogens. in this study, extended-spectrum beta-lactamase (esbl) producing and non-producing escherichia coli, klebsiella pneumoniae and pseudomonas aer ... | 2015 | 26313278 |
| risk factors for in-hospital mortality in patients with type 2 diabetes complicated by community-acquired klebsiella pneumoniae bacteremia. | patients with diabetes are at a high risk of infection-related morbidity and mortality. klebsiella pneumoniae bacilli are prevalent among diabetic patients, especially in asian populations. the present study aimed to identify risk factors for in-hospital mortality among diabetic patients complicated by community-acquired k. pneumoniae bacteremia. | 2015 | 26315482 |
| pleural and pericardial effusions combined with ascites in a patient with severe sunitinib-induced hypothyroidism. | to best of our knowledge, this is the first reported case of pericardial and pleural effusions combined with ascites, precipitated with severe sunitinib-induced hypothyroidism. a 58-year-old man presented in our emergency department due to dyspnoea and dry cough. sixteen months earlier, the patient underwent left nephrectomy due to metastatic renal cell adenocarcinoma (rcc), and therapy with sunitinib was initiated postoperatively. thyroid function was not assessed during the therapy. on admissi ... | 2016 | 26319226 |
| attributable mortality of carbapenem-resistant klebsiella pneumoniae infections in a prospective matched cohort study in italy, 2012-2013. | in italy, infections with carbapenem-resistant klebsiella pneumoniae (crkp) have increased markedly since 2009, creating unprecedented problems in healthcare settings and limiting treatment options for infected patients. | 2016 | 26319590 |
| comparative in vitro activity of oral antimicrobial agents against enterobacteriaceae from patients with community-acquired urinary tract infections in three european countries. | enterobacteriaceae causing community-acquired urinary tract infections were examined in selected outpatient clinics and hospitals in belgium, germany and spain using eucast breakpoints for susceptibility. a total of 1190 isolates were collected. escherichia coli isolates were resistant to amoxicillin-clavulanic acid (28.1%), ciprofloxacin (23.4%) and trimethoprim-sulfamethoxazole (21.4%) compared with fosfomycin and nitrofurantoin (each, <1.5%). ceftibuten (mic50/90 0.25/0.5 mg/l) and ceftriaxon ... | 2016 | 26321667 |
| mobile phones: reservoirs for the transmission of nosocomial pathogens. | global burden of hospital-associated infection (hai) is on the rise and contributes significantly to morbidity and mortality of the patients. mobile phones are indispensible part of communication among doctors and other health care workers (hcws) in hospitals. hands of hcws play an important role in transmission of hai and mobile phones which are seldom cleaned and often touched during or after the examination of patients without hand washing can act as a reservoir for transmission of potent pat ... | 2015 | 26322292 |
| role of efflux pumps inhibitor in decreasing antibiotic resistance of klebsiella pneumoniae in a tertiary hospital in north india. | the contribution of efflux systems to drug resistance in enterobacteriaceae is becoming increasingly appreciated. this study phenotypically analyzed the role of efflux mechanisms in resistance to ertapenem, doripenem, and tigecycline among clinical isolates of carbapenem-resistant klebsiella pneumoniae (crkp). | 2015 | 26322872 |
| investigation of clonal relationships of k. pneumoniae isolates from neonatal intensive care units by pfge and rep-pcr. | clonal relationships of klebsiella pneumoniae strains obtained during an epidemic and after a one-year post-epidemic (non-epidemic) period in the same neonatal intensive care unit (nicu) using pulsed-field gel electrophoresis (pfge) and repetitive polymerase chain reaction (rep-pcr) by the diversilab (dl) system were investigated, and the results of both molecular techniques were evaluated. | 2015 | 26322874 |
| extended-spectrum beta-lactamase-producing enterobacteriaceae (esbl-pe) infections: are carbapenem alternatives achievable in daily practice? | to avoid the use of carbapenems, alternatives such as cephamycin, piperacillin-tazobactam, and others are suggested for the treatment of extended-spectrum beta-lactamase-producing enterobacteriaceae (esbl-pe) infections. the aim of this study was to evaluate the frequency and the feasibility of antimicrobial de-escalation for esbl-pe-related infections. | 2015 | 26327124 |
| multiplex polymerase chain reaction assay developed to diagnose adult bacterial meningitis in taiwan. | acute bacterial meningitis causes high morbidity and mortality; the associated clinical symptoms often are insensitive or non-specific; and the pathogenic bacteria are geographically diverse. clinical diagnosis requires a rapid and accurate methodology. this study aimed to develop a new multiplex polymerase chain reaction (mpcr) assay to detect simultaneously six major bacteria that cause adult bacterial meningitis in taiwan: klebsiella pneumoniae, pseudomonas aeruginosa, streptococcus pneumonia ... | 2015 | 26332098 |
| distinct but spatially overlapping intestinal niches for vancomycin-resistant enterococcus faecium and carbapenem-resistant klebsiella pneumoniae. | antibiotic resistance among enterococci and γ-proteobacteria is an increasing problem in healthcare settings. dense colonization of the gut by antibiotic-resistant bacteria facilitates their spread between patients and also leads to bloodstream and other systemic infections. antibiotic-mediated destruction of the intestinal microbiota and consequent loss of colonization resistance are critical factors leading to persistence and spread of antibiotic-resistant bacteria. the mechanisms underlying m ... | 2015 | 26334306 |