Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| chlamydia pneumoniae respiratory infections in taiwan. | to understand the epidemiology of chlamydia pneumoniae acute infections in taiwan, we collected 116 paired and 244 single sera from patients suspected of c. pneumoniae infection and conducted microimmunofluorescence test. eighty-three patients (83/360, 23%) met the diagnostic criteria of current c. pneumoniae infection. the c. pneumoniae infections were significantly higher in men than in women (p< or =0.0001) and were most frequent in the group of 40-49 year-olds, and the people older than 70 y ... | 2007 | 17579263 |
| detection of amyloid beta aggregates in the brain of balb/c mice after chlamydia pneumoniae infection. | neuroinflammation, initiated by cerebral infection, is increasingly postulated as an aetiological factor in neurodegenerative diseases such as alzheimer's disease (ad). we investigated whether chlamydia pneumoniae (cpn) infection results in extracellular aggregation of amyloid beta (abeta) in balb/c mice. at 1 week post intranasal infection (p.i.), cpn dna was detected predominantly in the olfactory bulbs by pcr, whereas brains at 1 and 3 months p.i. were cpn negative. at 1 and 3 months p.i., ex ... | 2007 | 17581756 |
| the effect of infectious burden on the prevalence of atopy and respiratory allergies in iceland, estonia, and sweden. | epidemiologic reports on the effect of microbe exposure on the development of atopy and allergic asthma are inconsistent. | 2007 | 17586034 |
| gene expression profiles of chlamydophila pneumoniae during the developmental cycle and iron depletion-mediated persistence. | the obligate intracellular, gram-negative bacterium chlamydophila pneumoniae (cpn) has impact as a human pathogen. little is known about changes in the cpn transcriptome during its biphasic developmental cycle (the acute infection) and persistence. the latter stage has been linked to chronic diseases. to analyze cpn cwl029 gene expression, we designed a pathogen-specific oligo microarray and optimized the extraction method for pathogen rna. throughout the acute infection, ratio expression profil ... | 2007 | 17590080 |
| evaluation of the diagnostic usefulness of real-time pcr for detection of chlamydophila pneumoniae in acute respiratory infections. | we investigated whether a real-time polymerase chain reaction (pcr) test is a useful diagnostic tool for identifying individuals with acute respiratory chlamydophila pneumoniae infections. nasopharyngeal swab specimens and peripheral blood mononuclear cells (pbmcs) from 100 patients with acute respiratory tract infections and 140 asymptomatic healthy subjects (controls) were analyzed using real-time pcr, culture, and serology for the detection of c. pneumoniae. six patients had serological resul ... | 2007 | 17593507 |
| identification of a ubig-like gene involved in ubiquinone biosynthesis from chlamydophila pneumoniae ar39. | to investigate if one hypothetical protein from chlamydophila pneumoniae ar39 exerts ubig-like function by complementary experiments. | 2007 | 17594460 |
| lack of association between chlamydophila pneumoniae seropositivity and abdominal aortic aneurysm. | chronic chlamydophila pneumoniae infection has been suggested as a possible contributing factor for the development and expansion of abdominal aortic aneurysm (aaa). the relevance of c pneumoniae involved in the processes underlying aneurysmal rupture is unknown. the aim of this study was to examine the relationship between c pneumoniae seropositivity and aaa rupture. in a case-control study, 119 patients with aaa and 36 matched controls were prospectively investigated with c pneumoniae serology ... | 2007 | 17595392 |
| prevalence of chlamydia in patients attending gynecological clinics in south eastern nigeria. | chlamydia infections have been reported to cause silent infections in communities which becomes endemic and could remain unnoticed for a very long time. in most parts of nigeria these organisms are not screened for, and hence relative information about frequencies of the organisms are sparse. | 2007 | 17604521 |
| mycoplasma pneumoniae and chlamydophila pneumoniae in children with community-acquired pneumonia in thailand. | the prevalence of community-acquired pneumonia (cap) caused by atypical pathogens in thai children is unknown. | 2007 | 17609060 |
| cell-specific interleukin-15 and interleukin-15 receptor subunit expression and regulation in pneumococcal pneumonia--comparison to chlamydial lung infection. | interleukin (il)-15 has critical impact on the homeostasis and activation of natural killer cells, natural killer t cells, gammadeltat cells, and cd8(+)t cells, and contributes to antimicrobial defenses particularly at mucosal sites. the respiratory tract comprises a large mucosal surface and harbors significant amounts of lymphocytes, however the expression pattern of il-15 in the lung and its role in local immune responses are largely unknown. we therefore analyzed the differential expression ... | 2007 | 17611121 |
| concentrations in plasma, epithelial lining fluid, alveolar macrophages and bronchial mucosa after a single intravenous dose of 1.6 mg/kg of iclaprim (ar-100) in healthy men. | a validated microbiological assay was used to measure concentrations of iclaprim (ar-100) in plasma, bronchial mucosa (bm), alveolar macrophages (am) and epithelial lining fluid (elf) after a single 1.6 mg/kg intravenous 60 min iv infusion of iclaprim. | 2007 | 17623694 |
| community-acquired pneumonia by chlamydophila pneumoniae: a clinical and incidence study in brazil. | as there was not any data on chlamydia pneumoniae (twar) infections in brazil so far, a prospective cohort study of adult patients hospitalized due to cap was carried out for one year in a brazilian university general hospital to detect the incidence of cap by chlamydophila pneumoniae (twar) for one year. during a whole year 645 consecutive patients hospitalized due to an initial presumptive diagnosis of respiratory diseases by icd-10 (j00-j99), excluding upper respiratory diseases, were screene ... | 2007 | 17625732 |
| q fever community-acquired pneumonia in a patient with crohn's disease on immunosuppressive therapy. | community-acquired pneumonia (cap) may be caused by typical or atypical pathogens. the three most common zoonotic atypical pathogens are chlamydophila psittaci (psittacosis), francisella tularensis (tularemia), and coxiella burnetii (q fever). atypical caps are suggested by a distinctive pattern of extrapulmonary organ involvement. zoonotic cap may be differentiated from nonzoonotic cap (chlamydia pneumoniae, mycoplasma pneumoniae, legionnaire's disease) by a recent zoonotic vector contact histo ... | 2007 | 17628200 |
| differences in the etiology of community-acquired pneumonia according to site of care: a population-based study. | a few population-based studies assessing the etiology of community-acquired pneumonia in both hospitalized and ambulatory patients, with special emphasis on the etiologic role of viral infections, have been reported. the purpose of this study was to assess microbiological differences according to initial site of care in patients with community-acquired pneumonia. | 2007 | 17629472 |
| characterization of in vitro chlamydial cultures in low-oxygen atmospheres. | to mimic in vivo conditions during chlamydial infections, chlamydia trachomatis serovar d and chlamydia pneumoniae cwl029 were cultured in low-oxygen atmospheres containing 4% o(2), with parallel controls cultured in atmospheric air. both were enriched with 5% co(2). the results showed a dramatic increase in the growth of c. pneumoniae but not of c. trachomatis. | 2007 | 17631631 |
| [chronic bacterial-and-viral vasculitis as a possible risk factor of disordered stability of the coronary atherosclerosis course]. | in order to assess the real significance of some plasma and vascular indices in disorders of the stable course of coronary heart disease (chd) in chronic bacterial- and viral infection-invasion, we determined the blood plasma lipid hydrogen peroxide (lhp) activity, a direct index of the lipid peroxidation degree, and measured the concentration of specific antibodies to chlamydia pneumoniae (c. pneunoniae), herpes simplex virus type 1 (hsv-1), cytomegalovirus (cmv) and epstein-barr virus (ebv) by ... | 2006 | 17641612 |
| [impact of chronic chlamydia pneumoniae infection on left ventricular remodeling after myocardial infarction]. | postmyocardial infarction left ventricular remodeling is modified by inflammatory processes and structural changes in the myocardium. chlamydia pneumoniae (chp) causes chronic myocyte infection, affects apoptosis and tnf-alpha production, and may induce cross reactivity with alpha myosin. this is the way in which this intracellular pathogen may modulate remodeling on the cellular and organ level. | 2006 | 17642135 |
| no prognostic significance of chronic infection with chlamydia pneumoniae in acute coronary syndromes: insights from the global utilization of strategies to open occluded arteries iv acute coronary syndromes trial. | although relationships between chronic chlamydia pneumoniae (cpn) infection and the risk of coronary events in stable coronary artery disease patients have been reported, a similar link in acute coronary syndrome (acs) patients has not been consistently observed. | 2007 | 17643581 |
| inoculation of chlamydia pneumoniae or chlamydia trachomatis with ligands that inhibit attachment to host cells reduces infectivity in the mouse model of lung infection: implication for anti-adhesive therapy. | previous studies have shown that the chlamydial glycan contains a high-mannose oligosaccharide, which mediates attachment and infectivity of the organism. removal of the glycan decreases infectivity in vitro and in vivo. the present study demonstrates that simultaneous inoculation of chlamydial organisms and a ligand that prevents glycan binding reduces lung burden in infected animals. | 2007 | 17656142 |
| infectious aetiology in acute coronary syndromes. | to ascertain the relationship between seropositivity to chronic infections with helicobacter pylori, chlamydia pneumoniae and cytomegalovirus (cmv) and acute coronary syndromes and association of each of these infective agent with biochemical parameters and cardiovascular risk factors. | 2002 | 17657038 |
| the ongoing debate over the association between chlamydia pneumoniae infection and coronary artery disease: antibiotic dilemma. | 2008 | 17662493 | |
| [chlamydophila pneumoniae, a possible cause of mononucleosis syndrome]. | 2007 | 17663971 | |
| i/st mice hypersusceptible to mycobacterium tuberculosis are resistant to m. avium. | we previously demonstrated that mice of the i/st strain are extremely susceptible to mycobacterium tuberculosis, as well as to the taxonomically distant intracellular bacteria chlamydia pneumoniae and salmonella enterica. to broaden our knowledge about the control of susceptibility to intracellular pathogens, we studied the infection caused by mycobacterium avium virulent strain 724 in a panel of inbred mouse strains and found that i/st mice are resistant to m. avium. by comparing i/st mice with ... | 2007 | 17664269 |
| chlamydia pneumoniae and symptomatic carotid atherosclerotic plaque: a prospective study. | to investigate the possible link between symptomatic carotid atherosclerotic plaque and chlamydia pneumoniae. | 2007 | 17665001 |
| [application of the recombinant protein momp(vd2-vd3) from chlamydia pneumoniae in sero diagnosis]. | to express the recombinant protein momp(vd2-vd3) of chlamydia pneumoniae, and research on the immunocompetence of the momp(vd2-vd3) to support serodiagnosis,pcr and gene recombinant technique was used to clone the targeted dna fragment from a strain ar-39. the recombinant plasmid was induced in e. coli bl21 after having constructed the prokaryotic expression system, then the immunocompetence of the expression product was analyzed by western blot and indirected elisa which is based on the animal ... | 2007 | 17672316 |
| characterization of the 3' exonuclease of chlamydophila pneumoniae endonuclease iv on double-stranded dna and the rna strand of rna/dna hybrid. | endonuclease iv has ap endonuclease and 3'-repair diesterase activities. here, we report chlamydophila pneumoniae endonuclease iv (cpendoiv) could hydrolyze the ds dna and the rna strand of rna/dna hybrid from the 3' end, yet the dna strand of rna/dna hybrid was not the effective substrate of cpendoiv. the optimal ph for 3' exonuclease on double-stranded (ds) dna and rna/dna hybrids were both basic, but with some difference. the effect of divalent ions (mg(2+), ca(2+), zn(2+), cu(2+), ni(2+), an ... | 2007 | 17681276 |
| lack of association between infectious burden and carotid atherosclerosis in japanese patients. | several infectious agents, such as chlamydia pneumoniae, cytomegalovirus (cmv), herpes simplex virus (hsv), and helicobacter pylori, have been implicated in the pathogenesis of atherosclerosis; however, but the contribution of infection may vary among races and geographic conditions. the present study investigates the association between the presence of these pathogens and carotid atherosclerosis and examines the relevance of an infectious burden during atherogenesis in japanese patients undergo ... | 2007 | 17689410 |
| characterization of an acid-dependent arginine decarboxylase enzyme from chlamydophila pneumoniae. | genome sequences from members of the chlamydiales encode diverged homologs of a pyruvoyl-dependent arginine decarboxylase enzyme that nonpathogenic euryarchaea use in polyamine biosynthesis. the chlamydiales lack subsequent genes required for polyamine biosynthesis and probably obtain polyamines from their host cells. to identify the function of this protein, the cpn1032 homolog from the respiratory pathogen chlamydophila pneumoniae was heterologously expressed and purified. this protein self-cl ... | 2007 | 17693492 |
| risk factor analysis of acute respiratory distress syndrome among hospitalized patients with chlamydophila pneumoniae pneumonia. | chlamydophila pneumoniae (c. pneumoniae) pneumonia-associated acute respiratory distress syndrome (ards) is rare and has been seldom reported, but the outcome is usually fatal. this study was designed to identify the risk factors for hospitalized c. pneumoniae patients developing ards and to describe the outcomes. | 2007 | 17698431 |
| a multiplex pcr assay for the detection of respiratory bacteriae in nasopharyngeal smears from children with acute respiratory disease. | to elucidate the frequency of infections with pathogenic respiratory bacteriae during an inter-epidemic period a multiplex pcr assay was used to screen nasopharyngeal smears for the presence of dna specific for bordetella pertussis, bordetella parapertussis, chlamydophila pneumoniae and mycoplasma pneumoniae. 187 samples from children aged 2-14 y were analysed with this method in addition to classical bacteriology and compared to results obtained with commercially available pcr kits for each sin ... | 2007 | 17701714 |
| prevalence of active infection with chlamydia pneumoniae and human cytomegalovirus in patients with type ii diabetes mellitus. | by promoting the inflammatory process in the arterial wall, chlamydia pneumoniae (cpn) and human cytomegalovirus (cmv) participate in the pathogenesis of cardiovascular disease (cvd). since patients with diabetes mellitus (dm) are at high risk of cvd, we studied markers of cmv and cpn infection in dm patients as possible predictors of cardiovascular complications. the seroprevalence rates of cmv in 44 dm patients and matched controls were 74 and 88%, respectively. compared with controls, patient ... | 2007 | 17702468 |
| chlamydia pneumoniae antibody titers and cardiac calcifications: a cross-sectional serological-echocardiographic correlative study. | chlamydia pneumoniae has previously been associated with higher prevalence of valvular and cardiac calcifications. | 2007 | 17710782 |
| trace element balance is changed in infected organs during acute chlamydophila pneumoniae infection in mice. | most infectious diseases are accompanied by changed levels of several trace elements in the blood. however, sequential changes in trace elements in tissues harbouring bacterial infections have not been studied. in the present study the respiratory pathogen chlamydophila pneumoniae (c. pneumoniae), adapted to c57bl/6j mice, was used to study whether the balance of trace elements is changed in infected organs. bacteria were quantitatively measured by real-time pcr in the blood, lungs, liver, aorta ... | 2008 | 17712530 |
| natural killer t (nkt) cell subsets in chlamydial infections. | natural killer t (nkt) cells are a newly identified unique subset of cells that express both alphabeta t cell receptor and nk cell markers. we investigated the role of nkt cells in modulating adaptive t cell responses in chlamydial infections using human-disease-related chlamydial species. our study provides in vivo evidence that even closely related pathogens may activate different functional nkt subsets, which can further polarize cd4+ and cd8+ cells in adaptive immune responses. | 2007 | 17713011 |
| elevated levels of anti-chlamydia pneumoniae iga and igg antibodies in young adults with ischemic stroke. | data on the role of chlamydia pneumoniae in patients with ischemic stroke are inconsistent. we investigated the presence of anti-c. pneumoniae antibodies in young adults with ischemic stroke. | 2007 | 17714326 |
| intrapulmonary pharmacodynamics of high-dose levofloxacin in subjects with chronic bronchitis or chronic obstructive pulmonary disease. | the objective of this study was to determine the plasma and intrapulmonary pharmacokinetic parameters of intravenously administered levofloxacin in subjects with stable chronic lung disease. three doses of 1000 mg levofloxacin were administered once daily to 16 adult subjects divided into four groups of 4 subjects each. standardised bronchoscopy and timed bronchoalveolar lavage (bal) were performed at 4 h, 8 h, 12 h and 24 h following administration of the last dose. blood was obtained for drug ... | 2007 | 17716873 |
| effects of bradykinin on aortic endothelial function in apoe-knockout mice with chronic chlamydia pneumoniae infection. | impaired muscarinic receptor-mediated vasodilation is an important feature of early atherosclerosis. earlier studies on apolipoprotein e-knockout mice (apoe-ko) mice suggested adverse effects of chlamydia pneumoniae infection on the endothelial vasomotor responses of aortas to the muscarinic agonist methacholine. using additional aorta samples the present study investigated the responses to bradykinin. | 2007 | 17721032 |
| exposure to chlamydia pneumoniae infection and age-related macular degeneration: the blue mountains eye study. | to assess cross-sectional and longitudinal associations between exposure to chlamydia pneumoniae infection and age-related macular degeneration (amd) in the nested case-control sample drawn from the blue mountains eye study (bmes) cohort. | 2007 | 17724180 |
| chlamydia pneumoniae infection of aortic smooth muscle cells reduces platelet-derived growth factor receptor-beta expression. | chlamydia pneumoniae infection may play a role in the pathogenesis of atherosclerosis. in this study, an oligonucleotide microarray was utilized to examine the transcriptional response of human aortic smooth muscle cells (aosmc) to c. pneumoniae infection. alteration of mrna expression in 71 out of 780 genes was detected at 24 h after infection. among the down-regulated genes, platelet-derived growth factor receptor-beta (pdgfr-beta) was identified as a target for further analysis because the pd ... | 2007 | 17727656 |
| an efficient cloning of dna fragments by a method based on uracil-dna glycosylase and endonuclease iv. | we introduced a novel method to clone random dna fragments independent of ligation reaction. the method involves the generation of long protruding ends on pcr amplification dna. both oligonucleotides used for the amplification of the vector dna carried one uracil residue at the tenth position from the 5' end and this made the creation of the 3' protruding ends of linearized vector possible by uracil-dna glycosylase (udg) and endonuclease iv (endo iv). 76 groups of annealed oligonucleotides that ... | 2008 | 17765318 |
| chlamydophila pneumoniae pknd exhibits dual amino acid specificity and phosphorylates cpn0712, a putative type iii secretion yscd homolog. | chlamydophila pneumoniae is an obligate intracellular bacterium that causes bronchitis, pharyngitis, and pneumonia and may be involved in atherogenesis and alzheimer's disease. genome sequencing has identified three eukaryote-type serine/threonine protein kinases, pkn1, pkn5, and pknd, that may be important signaling molecules in chlamydia. full-length pknd was cloned and expressed as a histidine-tagged protein in escherichia coli. differential centrifugation followed by sodium carbonate treatme ... | 2007 | 17766419 |
| cd8+ t cell protective immunity against chlamydia pneumoniae includes an h2-m3-restricted response that is largely cd4+ t cell-independent. | cd8+ t cells are important for immunity to the intracellular bacterial pathogen chlamydia pneumoniae (cpn). recently, we reported that type 1 cd8+ (tc1) from cpn-infected b6 mice recognize peptides from multiple cpn ags in a classical mhc class ia-restricted fashion. in this study, we show that cpn infection also induces nonclassical mhc class ib-(h2-m3)-restricted cd8+ t cell responses. h2-m3-binding peptides representing the n-terminal formylated sequences from five cpn ags sensitized target c ... | 2007 | 17785832 |
| chronic infections and genetic factors in the development of ischemic stroke. | the aim of this study was to examine whether chronic infections and genetic factors of the host play roles in the pathophysiology of acute noncardioembolic ischemic stroke. blood samples from 59 subjects with ischemic stroke and 52 control patients were investigated by nested pcr for the presence of c. pneumoniae dna, hcmv dna and enterovirus rna, by elisa for the levels of antibodies to c. pneumoniae, hcmv, hsv, hhv-6, ebv and the inflammatory chemokine il-8, and by pcr for promoter polymorphis ... | 2007 | 17802898 |
| rapid multiplex nested pcr for detection of respiratory viruses. | respiratory tract infections can be caused by a heterogeneous group of viruses and bacteria that produce similar clinical presentations. specific diagnosis therefore relies on laboratory investigation. this study developed and evaluated five groups of multiplex nested pcr assays that could simultaneously detect 21 different respiratory pathogens: influenza a virus (h1n1, h3n2, and h5n1); influenza b virus; parainfluenza virus types 1, 2, 3, 4a, and 4b; respiratory syncytial virus a and b; human ... | 2007 | 17804659 |
| aetiological diagnosis of community acquired pneumonia: utility of rapid microbiological methods with respect to disease severity. | the present study investigated the utility of rapid microbiological methods in the aetiological diagnosis of community acquired pneumonia (cap) according to the severity of cap. between 1999 and 2004, 384 adult patients with cap were studied prospectively. in addition to standard microbiological methods, pcr and antigen detection techniques were used to identify pathogens. a total of 230 microbial agents in 209 patients were identified, with 134 (58.2%) identified by antigen detection or pcr tes ... | 2008 | 17852937 |
| microbiological aspects of bacterial lower respiratory tract illness in children: atypical pathogens. | 'atypical' lower respiratory tract pathogens often cause a distinct identifiable syndrome in adults, but in children the clinical presentation of atypical, typical and viral pneumonia is less well differentiated. specific microbiological investigations are usually required, but an understanding of their strengths and weaknesses is necessary to make interpretation possible. this review examines clinical presentation, microbiology and current evidence surrounding diagnostic techniques for mycoplas ... | 2007 | 17868919 |
| acute exacerbation of idiopathic pulmonary fibrosis: role of chlamydophila pneumoniae infection. | patients with idiopathic pulmonary fibrosis (ipf) may experience acute exacerbations of their illness. the actual trigger(s) of such exacerbations is unknown. chlamydophila pneumoniae infection can cause exacerbation of asthma and copd. a prospective study was conducted to investigate the possible role of c. pneumoniae infection in triggering acute exacerbations of ipf. | 2007 | 17875058 |
| chlamydiae and mycoplasma infections in pulmonary malt lymphoma. | chlamydia pneumoniae, chlamydia trachomatis and chlamydia psittaci were detected at low frequencies (<20%) among 69 pulmonary mucosa-associated lymphoid tissue (malt) lymphomas, 30 other lymphoproliferative disorders (lpd) and 44 non-lpd. the incidence of individual chlamydiae was generally higher in malt lymphoma than non-lpd, although not reaching statistical significance. mycoplasma pneumoniae dna was not detected. | 2007 | 17876330 |
| chronic infections and histamine, crp and il-6 levels after percutaneous transluminal coronary angioplasty. | our hypothesis was that percutaneous transluminal coronary angioplasty (ptca) reactivates certain pathogens that contribute to inflammatory processes after the intervention. | 2007 | 17878998 |
| antimicrobial treatment of multiple sclerosis. | 2007 | 17882356 | |
| the development of asthma in wheezing infants with chlamydia pneumoniae infection. | chlamydia pneumoniae infection might play a role in the pathology of asthma, but its role in infantile asthma remains obscure. the presence of chlamydia pneumoniae was serologically determined in wheezing infants who were then re-examined 1-year later to determine whether or not asthma is associated with this type of infection. wheezing infants progressed to asthma more frequently after infection with chlamydia pneumoniae than those who were not infected. these findings suggested that chlamydia ... | 2007 | 17885860 |
| in vitro models of acute and long-term continuous infection of human respiratory epithelial cells with chlamydophila pneumoniae have opposing effects on host cell apoptosis. | persistent infection with the obligate intracellular pathogen chlamydophila pneumoniae has been implicated in the pathogenesis of many chronic diseases, but its mechanism remains unclear. many pathogens have been found to modulate cellular apoptosis in order to survive and multiply. chlamydial species were shown to both induce and inhibit host cell apoptosis depending on the experimental conditions. we utilized in vitro models of acute and long-term continuous (ltc) infection with the same cell ... | 2008 | 17888618 |
| identification of upper respiratory tract pathogens using electrochemical detection on an oligonucleotide microarray. | bacterial and viral upper respiratory infections (uri) produce highly variable clinical symptoms that cannot be used to identify the etiologic agent. proper treatment, however, depends on correct identification of the pathogen involved as antibiotics provide little or no benefit with viral infections. here we describe a rapid and sensitive genotyping assay and microarray for uri identification using standard amplification and hybridization techniques, with electrochemical detection (ecd) on a se ... | 2007 | 17895966 |
| chlamydia pneumoniae is a likely risk factor for ischemic stroke in young patients. | recently, chlamydia pneumoniae has been identified as a risk factor for atherosclerosis, cardiovascular disease, and stroke. in young patients the causes of stroke are more diverse, and remain unknown in about 30% of cases, despite thorough investigations. to find a possible relationship between c. pneumoniae infection and stroke at young age, we investigated c. pneumoniae antibody titers in 41 patients with ischemic stroke who were younger than 50 years old and in 55 healthy control subjects. a ... | 2004 | 17903955 |
| detection of parvovirus b19 and chlamydophila pneumoniae in a patient with atypical sarcoidosis. | we present an elderly female patient with fever, aplastic anemia, arthralgic symptoms and atypical pneumonia. serological and clinical findings suggested parvovirus b19 and chlamydophila pneumoniae infection. these supposed infections delayed the recognition of underlying sarcoidosis which definitive diagnosis was reached through a lung biopsy and histological demonstration of nonnecrotizing granulomas containing giant cells and noncaseating epithelioid cells. the present case highlights the pot ... | 2009 | 17906838 |
| simkania negevensis in community-acquired pneumonia in italian children. | simkania negevensis, a recently found chlamydia-like organism, has been associated with respiratory infections in children and adults with pneumonia, but s. negevensis findings have been common also without any infection. the aims of the present paper were to evaluate s. negevensis in the aetiology of paediatric community-acquired pneumonia (cap), its seroprevalence in north italian children, and whether there is cross-reactivity between s. negevensis and chlamydia pneumoniae serology. antibodie ... | 2008 | 17907044 |
| chlamydia pneumoniae inclusion membrane protein cpn0585 interacts with multiple rab gtpases. | chlamydiae are intracellular bacteria that develop within a membrane-bound vacuole called an inclusion. to ensure that the inclusion is a safe niche for chlamydial replication, chlamydiae exploit a number of host cell processes, including membrane-trafficking pathways. recently, several rab gtpases were found to associate with the inclusions of various chlamydial species. here we report that cpn0585, a chlamydia pneumoniae inclusion membrane protein (inc), interacts with multiple rab gtpases. th ... | 2007 | 17908815 |
| chlamydia pneumoniae seropositivity in aetiological subtypes of brain infarction and carotid atherosclerosis: a case control study. | many patients with brain infarction (bi) lack traditional risk factors, suggesting that other factors (including infectious agents) might contribute to stroke risk. we investigated chlamydia pneumoniae infection in a large cohort of patients with bi according to aetiological subtypes and carotid atherosclerosis. | 2008 | 17911183 |
| rifalazil and other benzoxazinorifamycins in the treatment of chlamydia-based persistent infections. | rifalazil is a benzoxazinorifamycin which inhibits bacterial dna-dependent rna polymerase. the benzoxazine ring endows benzoxazinorifamycins with unique physical and chemical characteristics which favor the use of rifalazil and derivatives in treating diseases caused by the obligate intracellular pathogens of the genus chlamydia. minimal inhibitory concentrations of benzoxazinorifamycins against chlamydia are in the pg/ml range. these compounds have potential as monotherapeutic agents to treat c ... | 2007 | 17912677 |
| chlamydophilal antigens induce foam cell formation via c-jun nh2-terminal kinase. | chlamydophila pneumoniae is known to be associated with atherosclerosis. recent studies have reported that components of chlamydophila pneumoniae (chlamydophilal antigens) induce foam cell formation in macrophages. however, the mechanism of foam cell formation induced by chlamydophilal antigens has yet to be elucidated. in this paper, we first found that mitogen-activated protein kinases including extracellular signal-regulated kinase, p38 and c-jun nh2 terminal kinase are phosphorylated after s ... | 2007 | 17913539 |
| genetic diversity of the obligate intracellular bacterium chlamydophila pneumoniae by genome-wide analysis of single nucleotide polymorphisms: evidence for highly clonal population structure. | chlamydophila pneumoniae is an obligate intracellular bacterium that replicates in a biphasic life cycle within eukaryotic host cells. four published genomes revealed an identity of > 99 %. this remarkable finding raised questions about the existence of distinguishable genotypes in correlation with geographical and anatomical origin. | 2007 | 17916241 |
| molecular beacons for isothermal fluorescence enhancement by the cleavage of rnase hii from chlamydia pneumoniae. | this article describes a new assay for isothermal enhancement of fluorescence intensity. the assay is based on the cleavage of duplexes formed by the chimeric dna-rn(1)-dna molecular beacon (cmb) and target dna with chlamydia pneumoniae rnase hii (cprnase hii). the loop sequence of the cmb, which was designed according to the target sequence, contains a single ribonucleotide. the combination of cprnase hii cleavage and cmb (rhmb) permitted a 90-fold increase in fluorescence intensity change comp ... | 2007 | 17923101 |
| in vitro and in vivo antibacterial activities of dc-159a, a new fluoroquinolone. | dc-159a is a new 8-methoxy fluoroquinolone that possesses a broad spectrum of antibacterial activity, with extended activity against gram-positive pathogens, especially streptococci and staphylococci from patients with community-acquired infections. dc-159a showed activity against streptococcus spp. (mic(90), 0.12 microg/ml) and inhibited the growth of 90% of levofloxacin-intermediate and -resistant strains at 1 microg/ml. the mic 90s of dc-159a against staphylococcus spp. were 0.5 microg/ml or ... | 2008 | 17938194 |
| chlamydial infection showing migratory pulmonary infiltrates. | a 70-year old man was admitted to our hospital because of nonproductive cough, fever and increasing dyspnea associated with alveolar opacities on chest roentgenogram, which later migrated to previously unaffected areas. the diagnosis of chlamydial pneumonitis was made on serological grounds. organizing pneumonia was documented by transbronchial lung biopsies and the subsequent course was satisfactory under minocycline therapy. chlamydial infection should be considered in the differential diagnos ... | 2007 | 17938530 |
| chlamydia pneumoniae accompanied by inflammation is associated with the progression of atherosclerosis in capd patients: a prospective study for 3 years. | the causes of accelerated atherosclerosis in end-stage renal disease (esrd) patients are unknown, although recent studies have suggested that chlamydia pneumoniae (cp) infection and inflammation might be contributing factors. we aimed to evaluate the association of carotid atherosclerosis progression with cp infection and inflammation in patients undergoing peritoneal dialysis (pd). | 2008 | 17940057 |
| common infectious agents in multiple sclerosis: a case-control study in children. | environmental factors, in particular infections, have been linked with the risk of developing multiple sclerosis (ms). the association of epstein-barr virus infection with childhood onset of ms has been recently recognized. as other infections characteristically experienced during childhood have not yet been studied in larger cohorts of paediatric ms, we conducted a study on 152 german children with ms (age at onset <16 years) and matched controls in the hope of gaining evidence for their possib ... | 2008 | 17942525 |
| infections and obesity: a multinational epidemiological study. | viral infections have been associated with the aetiology of obesity in animal models. this study investigates the association between 7 serological markers of infections and body mass index (bmi) in a population based sample. individuals (n=985, mean age 42+/-97 (28-55) y, mean bmi 25.594.2) from iceland, sweden and estonia underwent a structured interview and blood sampling. igg antibodies were measured against helicobacter pylori and the caga protein, hepatitis a virus, toxoplasma gondii, herp ... | 2008 | 17943636 |
| an engineered l-arginine sensor of chlamydia pneumoniae enables arginine-adjustable transcription control in mammalian cells and mice. | for optimal compatibility with biopharmaceutical manufacturing and gene therapy, heterologous transgene control systems must be responsive to side-effect-free physiologic inducer molecules. the arginine-inducible interaction of the argr repressor and the argr-specific arg box, which synchronize arginine import and synthesis in the intracellular human pathogen chlamydia pneumoniae, was engineered for arginine-regulated transgene (art) expression in mammalian cells. a synthetic arginine-responsive ... | 2007 | 17947334 |
| evaluation of the presence of selected viral and bacterial nucleic acids in pericardial samples from dogs with or without idiopathic pericardial effusion. | many viruses have been identified in pericardial fluid and in tissue samples from humans with pericarditis by means of molecular diagnostics. in canine idiopathic pericardial effusion there is as yet no conclusive evidence to support the involvement of an infectious agent. this study was designed to investigate a possible relationship between idiopathic pericardial effusion in dogs and viruses most commonly encountered in humans affected with viral pericarditis. coxsackievirus b3 rna, influenza ... | 2009 | 17959400 |
| periodontitis may increase the risk of peripheral arterial disease. | the aim of this case control study was to evaluate whether periodontitis was associated with peripheral arterial disease (pad). | 2008 | 17964192 |
| pathogen burden in essential hypertension. | associations between pathogens and hypertension (ht) has been reported, but few studies have focused on the relationship between aggregate pathogens and ht. the present study explored whether the risk of ht is associated with each pathogen (defined as chlamydia pneumoniae (c. pneumoniaee), mycoplasma pneumoniae (m. pneumoniae), helicobacter pylori (h. pylori) and coxsackie virus) or with aggregate pathogens in chinese mongolians. | 2007 | 17965498 |
| correlation of hyperhomocysteinaemia and chlamydia pneumoniae igg seropositivity with coronary artery disease in a general population. | both chlamydia pneumoniae infection and hyperhomocysteinaemia have been assumed to increase the atherosclerotic risk independently of each other and independently of the classic risk factors. the correlation between hyperhomocysteinaemia, c. pneumoniae infection and coronary artery disease (cad) have not been investigated in the general population. | 2007 | 17974477 |
| currently used nucleic acid amplification tests for the detection of viruses and atypicals in acute respiratory infections. | for the detection of respiratory viruses conventional culture techniques are still considered as the gold standard. however, results are mostly available too late to have an impact on patient management. the latest developments include appropriate dna- and rna-based amplification techniques (both nasba and pcr) for the detection of an extended number of agents responsible for lrti. real time amplification, the latest technical progress, produces, within a considerable shorter time, results with ... | 2007 | 17977063 |
| rapid optimization of antimicrobial chemotherapy given to pediatric patients with community-acquired pneumonia using pcr techniques with serology and standard culture. | children (n = 117; mean age 2.4 +/- 2.9 years) were diagnosed as having community-acquired pneumonia (cap) using clinical symptoms, chest x-rays, and hematological data. the causative pathogen was determined using real-time polymerase chain reaction (pcr) (6 bacteria), multiple reverse transcription-pcr (mpcr; 11 viruses), bacterial culture, and serology. the initial chemotherapy was evaluated based on the pathogens identified using pcr. we found 27 viral cases (23.1%), 25 bacterial cases (21.4% ... | 2007 | 17982719 |
| detection of respiratory viruses and atypical bacteria in children's tonsils and adenoids. | the tonsils and adenoids of 44 children were analyzed for the detection of respiratory syncytial virus, influenza virus, parainfluenza virus, adenovirus, chlamydophila pneumoniae, and mycoplasma pneumoniae. viruses were detected in 47.7% of the children and 37.3% of the specimens, with adenovirus and parainfluenza viruses being the most frequently detected microorganisms. | 2008 | 17989193 |
| association of chlamydia pneumoniae infection with hla-b*35 in patients with coronary artery disease. | the immune system may interplay between chlamydia pneumoniae infection and coronary artery disease (cad). major histocompatibility complex genes regulate innate and adaptive immunity. patients with cad (n = 100) and controls (n = 74) were enrolled. human leukocyte antigens (hla-a, hla-b, and hla-drb1), four lymphotoxin alpha single-nucleotide polymorphisms, and complement c4a and c4b allotypes were typed, and their haplotypes were inferred. the presence of serum c. pneumoniae immunoglobulin a (i ... | 2008 | 17989341 |
| apolipoprotein e4 enhances attachment of chlamydophila (chlamydia) pneumoniae elementary bodies to host cells. | chlamydophila (chlamydia) pneumoniae is an intracellular respiratory pathogen known to cause community-acquired pneumonia. infection with this organism has been associated with atherosclerosis, inflammatory arthritis, and other chronic diseases, many of which also have been associated with possession of the epsilon4 allele at the apoe locus on (human) chromosome 19. an earlier study from this laboratory suggested that some relationship exists between apolipoprotein e4 (apoe4), the product of the ... | 2008 | 17997273 |
| [coinfection with mycoplasma pneumoniae and chlamydophila pneumoniae in a middle-aged adult]. | a 47-year-old man who suffered from fever and dry cough visited a local clinic. his symptoms temporarily improved with oral administration of ciprofloxacin, however, he was admitted to our hospital because of exacerbation. igm antibody for mycoplasma pneumoniae was positive and igm antibody titer for chlamydophila pneumoniae showed a high value of 7.12 index. thus, coinfection was diagnosed. the findings of chest x-ray and computed tomography were compatible with atypical pneumonia. clarithromyc ... | 2007 | 18018632 |
| chlamydophila pneumoniae induces a sustained airway hyperresponsiveness and inflammation in mice. | it has been reported that chlamydophila (c.) pneumoniae is involved in the initiation and promotion of asthma and chronic obstructive pulmonary diseases (copd). surprisingly, the effect of c. pneumoniae on airway function has never been investigated. | 2007 | 18021431 |
| proteolytic cleavage of the chlamydia pneumoniae major outer membrane protein in the absence of pmp10. | the genome of the obligate intracellular bacteria chlamydia pneumoniae contains 21 genes encoding polymorphic membrane proteins (pmp). while no function has yet been attributed to the pmps, they may be involved in an antigenic variation of the chlamydia surface. it has previously been demonstrated that pmp10 is differentially expressed in the c. pneumoniae cwl029 isolate. to evaluate whether the absence of pmp10 in the outer membrane causes further changes to the c. pneumoniae protein profile, w ... | 2007 | 18022938 |
| evidence for persistent chlamydia pneumoniae infection of human coronary atheromas. | to date, structures representing developmental stages of chlamydia pneumoniae, especially persistent forms of this intracellular bacteria, have not been described in human atherosclerotic tissues using specific antibody labeling and transmission electron microscopy. staining of atherosclerotic tissue from five patients seeking heart transplantation with gold-labeled antibodies specific for up-regulated chlamydial heat shock proteins, groel and groes, and visualisation via transmission electron m ... | 2008 | 18028932 |
| positive effect of flavonoids to cardiovascular and central nervous system. | moderate intake of wine may be protective against various neurologic, cardiovascular and gastroenteric diseases. low concentration of alcohol (wine diluted with water 1:2 to 1:10) exhibits strong antimicrobial activity against majority of gastrointestinal pathogens as well as against chlamydia pneumoniae. in contrast, higher doses of even diluted alcohol (more than 5-7 glasses a day) may cause severe neuropsychic disorders with major social consequences. wine contains variety of molecules with c ... | 2007 | 18030258 |
| development of real-time multiplex nucleic acid sequence-based amplification for detection of mycoplasma pneumoniae, chlamydophila pneumoniae, and legionella spp. in respiratory specimens. | real-time multiplex isothermal nucleic acid sequence-based amplification (nasba) was developed to detect mycoplasma pneumoniae, chlamydophila pneumoniae, and legionella spp. in respiratory specimens using the nuclisens basic kit (biomérieux, boxtel, the netherlands). oligonucleotide primers were derived from the m. pneumoniae, c. pneumoniae, and legionella pneumophila 16s rrna. for real-time detection, molecular beacons were used. specificity was established on a panel of bacterial strains. the ... | 2008 | 18032625 |
| is there a role for antibiotics in the treatment of asthma?: involvement of atypical organisms. | emerging evidence suggests an association between some asthma and pulmonary infection by the atypical organisms chlamydia pneumoniae and mycoplasma pneumoniae, but a causal role for infection remains unproven and controversial. most acute exacerbations of asthma are triggered by acute infections that are due to viral respiratory pathogens, not to bacteria or atypical organisms. administration of antibiotics for acute exacerbations of asthma has been shown to be ineffective. most evidence linking ... | 2000 | 18034578 |
| acute primary chlamydophila pneumoniae bronchitis and bronchial hyperresponsiveness in young nonasthmatic thai military recruits. | a correlation between chronic chlamydophila pneumoniae infection and chronic airway diseases has been suggested by several studies, but direct evidence to support the link between acute cpneumoniae infection and new-onset asthma is insufficient. | 2007 | 18051210 |
| endothelial cells are protected against phagocyte-transmitted chlamydophila pneumoniae infections by laminar shear stress gueinzius: shear stress protects from c. pneumoniae infection. | the respiratory pathogen chlamydophila pneumoniae can be detected in atherosclerotic vessels, but the mechanism of dissemination from lung to vasculature remains unknown. disturbance of vascular shear stress is a risk factor for atherosclerosis. we investigated whether polymorphonuclear neutrophils (pmn) might serve as carriers, transmitting c. pneumoniae to endothelial cells and how this is affected by shear stress. pmn were prepared from blood and incubated with c. pneumoniae. real-time pcr an ... | 2008 | 18054938 |
| [prevalence of chlamydia-pneumoniae-specific immunoglobulin m antibody and acute exacerbations of asthma in childhood]. | chlamydia pneumoniae is a frequent causative agent of acute respiratory disease and has been recently reported as a possible cause of asthma. we investigated the prevalence of c. pneumoniae infections in childhood patients with acute exacerbations of asthma. | 2007 | 18059151 |
| [human diseases caused by chlamydia and chlamydophila]. | chlamydiae and chlamydophilae are bacteria which are very common in the environment, the proof of which can be the recently described "environmental chlamydiae". the classical chlamydiae, such as chlamydia trachomatis and chlamydophila pneumoniae, posed a threat to human health, causing several diseases, including those with lethal course. in this article the biology and systematics of these bacteria and the diseases caused by them in humans, including those caused by classical and environmental ... | 2007 | 18059252 |
| serological profiling with chlamycheck, a commercial multiplex recombinant antigen western blot assay of chlamydial infections. | a new chlamydial test system, the chlamycheck assay, which uses 4 purified recombinant antigens of chlamydia trachomatis and chlamydophila pneumoniae and one antigen of chlamydophila psittaci, has been developed and commercialized. we investigated the reactivities of the recombinant antigens with sera from a group of 30 patients with acute chlamydia trachomatis infection, 88 patients consulting for sexually transmitted infections, and 46 patients with serological evidence of chlamydophila pneumo ... | 2007 | 18059568 |
| chlamydia pneumoniae aggravates vein graft intimal hyperplasia in a rat model. | along with angioplasty, autologus vein grafts are commonly used for artery bypass grafting in patients with advanced arterial stenosis and drug-resistant angina pectoris. although initially a successful procedure, long-term functionality is limited due to proliferation and migration of smooth muscle cells. like in atherosclerosis, common chronic infections caused by viruses and bacteria may contribute to this process of vein graft failure. here we investigated the possible role of chlamydia pneu ... | 2007 | 18062811 |
| common community infections and the risk for coronary artery disease and acute myocardial infarction: evidence for chronic over-expression of tumor necrosis factor alpha and vascular cells adhesion molecule-1. | although several common community infections have been associated with the risk for coronary artery disease (cad), their role in the development of acute myocardial infarction (ami) is still unclear. we examined the prevalence of igg and igm (or iga) antibodies against common infections such as hsv, hepatitis a (hav), helicobacter pylori (hp), cytomegalovirus (cmv) and chlamydia pneumoniae (cp), in cad and ami patients, and their relationship with pro-atherogenic inflammatory molecules. | 2008 | 18063147 |
| [a simultaneous detection of chlamydia pneumoniae and chlamydia trachomatis dna by real-time pcr]. | design and validation of a real-time pcr assay for quantitative detection of c. pneumoniae and c. trachomatis in clinical specimens. | 2007 | 18064798 |
| acute chlamydia pneumoniae infections in asthmatic and non-asthmatic military conscripts during a non-epidemic period. | chlamydia pneumoniae respiratory tract infections were studied in 512 male military conscripts (123 asthmatic and 389 non-asthmatic) taking part in 180-day service between july 2004 and july 2005 in kajaani, finland. respiratory tract infections requiring a medical consultation were analysed prospectively. at baseline, at end of service, and during each episode of respiratory infection, blood samples were obtained for measurement of c. pneumoniae antibodies. data concerning the clinical features ... | 2008 | 18070131 |
| chlamydia pneumoniae infection increases adherence of mouse macrophages to mouse endothelial cells in vitro and to aortas ex vivo. | interactions between monocytes/macrophages and endothelial cells play an important role in the pathogenesis of atherosclerosis, and the adherence of monocytes to the arterial endothelium is one of the early events in atherogenesis. in the present study, peritoneal macrophages harvested from green fluorescent protein (gfp) transgenic mice were used to analyze how chlamydia pneumoniae infection affects the adherence of gfp-macrophages to mouse endothelial cells in vitro and to the aorta from normo ... | 2008 | 18070891 |
| microbiology of community-acquired pneumonia in the gulf corporation council states. | in spite of advances in microbiological and serological investigations over the last two decades, etiological attribution remains difficult in community-acquired pneumonia (cap). even after exhaustive investigation, the etiology of cap remains unknown in up to 50% of patients. common pathogens include streptococcus pneumoniae, haemophilus influenzae and moraxella catarrhalis. in addition, several investigators document the importance of atypical pathogens including mycoplasma pneumoniae, chlamyd ... | 2007 | 18073166 |
| genetic control of susceptibility to pulmonary infection with chlamydia pneumoniae in the mouse. | a mouse model was used to study the genetic control of differential host response to pulmonary infection with chlamydia pneumoniae. the a/j and c57bl/6 strains show differential response to intranasal infection with respect to their ability to clear pulmonary bacterial load and the extent of lung pathology developed by 2 weeks post infection. the genetic basis of this interstrain difference was studied by whole-genome scan in an informative [a/j x c57bl/6j] f2 cross using the pulmonary microbial ... | 2008 | 18075514 |
| evaluation of the nuclisens minimag rna extraction and real-time nasba applications for the detection of mycoplasma pneumoniae and chlamydophila pneumoniae in throat swabs. | nucleic acids were extracted from 215 throat swabs from patients with community-acquired pneumonia by the manual boom extraction, the nuclisens minimag and the qiagen dna blood kit and amplified respectively by in-house real-time nasba, nuclisens easyq reagents, and real-time pcr for the detection of mycoplasma pneumoniae and chlamydophila pneumoniae. five out of 215 throat swabs were found to be c. pneumoniae positive by all techniques used. a total of 11 out of 215 throat swabs were positive f ... | 2008 | 18077024 |
| asthma and atypical bacterial infection. | a growing body of basic and clinical science implicates the atypical bacterial pathogens mycoplasma pneumoniae and chlamydophila (formerly chlamydia) pneumoniae as potentially important factors in asthma, although their exact contribution to asthma development and/or persistence remains to be determined. evidence from human studies links both m pneumoniae and c pneumoniae to new-onset wheezing, exacerbations of prevalent asthma, and long-term decrements in lung function, suggesting that these or ... | 2007 | 18079229 |
| absence of chlamydia pneumoniae and signs of atherosclerotic cardiovascular disease in adolescents with systemic lupus erythematosus. | patients with systemic lupus erythematosus (sle) have accelerated atherogenesis. a recent study suggested that chlamydia pneumoniae infection might also be a contributing factor in the development of atherogenesis in patients with sle. the objective of this study was to investigate the possible association of c. pneumoniae infection with markers of atherosclerosis in adolescents with sle compared with age-matched healthy controls. history and exam focused on cardiovascular risk factors were obta ... | 2008 | 18080155 |
| a multiplex pcr-based reverse line blot hybridization (mpcr/rlb) assay for detection of bacterial respiratory pathogens in children with pneumonia. | to develop and evaluate a novel method for simultaneous identification of 12 potential bacterial pathogens in children with community-acquired pneumonia. | 2008 | 18085683 |