Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| evaluation of the bact/alert 3d system for the implementation of in-house quality control sterility testing at canadian blood services. | background: until recently, canadian blood services (cbs) was performing quality control sterility testing of blood components using three different processes. this study was conducted in order to standardize sterility testing at all cbs centers in a cost-effective manner using the bact/alert 3d system. methods: blood components including fresh frozen plasma, platelet concentrates, and red blood cells were inoculated with eight bacterial species at target concentrations of 1 and 10 cfu/ml. pre- ... | 2010 | 20482299 |
| [systemic antibiotic therapy of acne vulgaris]. | inflammatory, medium to severe acne vulgaris is treated with systemic antibiotics worldwide. the rationale is an effect on propionibacterium acnes as well as the intrinsic anti-inflammatory properties of these antibiotics. although there are no correlations between the number of p. acnes and the severity of the disease, associations between the degree of humoral and cellular immune-responses against p. acnes and the severity of acne have been reported. exact data with respect to daily use of the ... | 2010 | 20482690 |
| isotretinoin: state of the art treatment for acne vulgaris. | summary isotretinoin (13-cis retinoic acid) is the most potent known inhibitor of sebum production. the multiple modes of action for isotretinoin, including suppression of sebaceous gland activity, normalization of the pattern of keratinization within the sebaceous gland follicle, inhibition of inflammation, reduction of growth of propionibacterium acnes in a secondary manner and, as currently shown, normalization of the expression of matrix tissue metalloproteinases and their inhibitors make th ... | 2010 | 20482692 |
| [modern aspects of acne pathogenesis]. | acne is worldwide the most common skin disease. | 2010 | 20482694 |
| [postoperative discitis due to propionibacterium acnes]. | 2010 | 20493657 | |
| selective microbial aerosolization in biogas demonstrated by quantitative pcr. | aerosolization of bacteria, archaea, synergistes, staphylococcus spp. and propionibacterium acnes was investigated in situ with quantitative real-time pcr of dna isolated from sludge and biogases of anaerobic digesters. the data revealed that in biogas, staphylococcus spp. and p. acnes were, respectively, aerosolized 30 and 220 times more and archaea and synergistes, respectively, 8 and 20 times less aerosolized than bacteria. this is the first demonstration of selective microbial aerosolization ... | 2010 | 20494574 |
| the human nasal microbiota and staphylococcus aureus carriage. | colonization of humans with staphylococcus aureus is a critical prerequisite of subsequent clinical infection of the skin, blood, lung, heart and other deep tissues. s. aureus persistently or intermittently colonizes the nares of approximately 50% of healthy adults, whereas approximately 50% of the general population is rarely or never colonized by this pathogen. because microbial consortia within the nasal cavity may be an important determinant of s. aureus colonization we determined the compos ... | 2010 | 20498722 |
| anti-acne-inducing bacterial activity of mangosteen fruit rind extracts. | the aims of this study were to determine the most effective solvent extract of mangosteen, anti-acne- inducing bacterial activity and the amount of alpha-mangostin, a major active component in each mangosteen fruit rind extract, using high-performance liquid chromatography (hplc). | 2010 | 20516704 |
| systemic toxicity of non-cell corynebacterium parvum (cp) in monkeys. | non-cell corynebacterium parvum product (ncpp) is a new preparation of corynebacterium parvum (cp), an immunomodulator that displays anticancer activities. it is prepared by nanotechnology and is intended to minimize the side effects of cp. the aim of the present study was to evaluate the immunogenicity and systemic toxicity of ncpp compared with cp in animals. | 2010 | 20519835 |
| syntheses and antibacterial activities of diterpene catechol derivatives with abietane, totarane and podocarpane skeletons against methicillin-resistant staphylococcus aureus and propionibacterium acnes. | natural catechol, quinone and quinone methide diterpenes with abietane (15-deoxyfuerstione, taxodione) and totarane (dispermone, 12,13-dihydroxy-8,11,13-totaratriene-6-one), and podocarpane (nimbidiol, deoxynimbidiol) skeletons were synthesized using ortho-oxidation of phenol with meta-chlorobenzoyl peroxide. minimum inhibitory activities of these diterpenes and previously synthesized natural diterpenes were measured against methicillin-resistant staphylococcus aureus (mrsa) and propionibacteriu ... | 2010 | 20522992 |
| detection of a new erm(x)-mediated antibiotic resistance in egyptian cutaneous propionibacteria. | a total of 107 antibiotic-resistant propionibacteria were isolated from the face of 102 egyptian acne patients, dermatology staff and controls. erythromycin-clindamycin-resistant propionibacteria were chosen to detect erm(x) gene and it was detected in 29 of 107 (27%) strains. however, just 7 strains had is1249i, 3 of them had also tn5432. the erm(x) gene which is not carried on tn5432 confers inducible resistance to telithromycin by erythromycin or clindamycin. the dna sequences of the pcr ampl ... | 2010 | 20541615 |
| metagenomic detection of phage-encoded platelet-binding factors in the human oral cavity. | the human oropharynx is a reservoir for many potential pathogens, including streptococcal species that cause endocarditis. although oropharyngeal microbes have been well described, viral communities are essentially uncharacterized. we conducted a metagenomic study to determine the composition of oropharyngeal dna viral communities (both phage and eukaryotic viruses) in healthy individuals and to evaluate oropharyngeal swabs as a rapid method for viral detection. viral dna was extracted from 19 p ... | 2011 | 20547834 |
| laser treatment of acne vulgaris. | traditional medical treatments for acne vulgaris include a variety of topical and oral medications. the combination of poor compliance, lack of durable remission, and potential side effects are common drawbacks to these treatments. the use of lasers and light devices has increased dramatically in recent years due to the overall ease of treatment, predictable clinical efficacy, and minimal adverse effects. a variety of light and laser devices has been used for the treatment of acne, including the ... | 2007 | 20567668 |
| laparoscopic ovarian tissue harvesting for cryopreservation: an effective and safe procedure for fertility preservation. | to critically review our experience with the method of laparoscopic ovarian tissue harvesting for ovarian cryopreservation. | 2010 | 20580151 |
| evaluation of the epinecidin-1 peptide as an active ingredient in cleaning solutions against pathogens. | we tested the activity of epinecidin-1, a novel antimicrobial peptide structurally related to pleurocidin, in commercial cleaning solutions stored at 4 and 25 degrees c for 7 and 14 days. the peptide's activities against enterococcus faecalis, escherichia coli, klebsiella oxytoca, pseudomonas aeruginosa, staphylococcus aureus, propionibacterium acnes, and candida albicans were measured in a minimum inhibitory concentration (mic) determination, minimal bactericidal concentration (mbc) determinati ... | 2010 | 20580756 |
| treatment of progressive macular hypomelanosis with narrow-band ultraviolet b phototherapy. | treatment for progressive macular hypomelanosis (pmh) has been disappointing. recently, propionibacterium acnes had been postulated as the causative agent and narrow-band ultraviolet b (nbuvb) had been shown to stimulate melanogenesis and has antibacterial properties. the aim of this study was to evaluate the effectiveness of nbuvb in the treatment of pmh. a retrospective analysis of pmh cases diagnosed and treated with nbuvb treatment from 1 january 2007 to 30 april 2009 at the national skin ce ... | 2010 | 20584255 |
| [clinical relevance of time-to-positivity in bactec9240 blood culture system]. | continuous monitoring systems have allowed determination of the time-to-positivity (ttp). we evaluated the clinical relevance of ttp in the bactec9240 system (becton-dickinson, usa). | 2010 | 20603588 |
| plasma concentration of propionibacterium acnes antibodies and prostate cancer risk: results from an australian population-based case-control study. | recent studies in prostatic tissue suggest that propionibacterium acnes (p. acnes), a bacterium associated with acne that normally lives on the skin, is the most prevalent bacterium in the prostate and in men with benign prostatic hyperplasia. its prevalence is higher in samples from patients subsequently diagnosed with prostate cancer. the aim of our study was to test whether circulating levels of p. acnes antibodies are associated with prostate cancer risk and tumour characteristics using plas ... | 2010 | 20606679 |
| acne epidemiology and pathophysiology. | the demographic profile of facial acne vulgaris has changed during the past several decades; 12 years of age is no longer the low end of the "normal" range for onset of acne. the available epidemiologic evidence raises more questions than it answers regarding the etiology of this downward shift. more study is needed to clarify whether the trend toward an earlier onset of puberty in the united states has influenced the clinical picture of acne. additional research will help advance understanding ... | 2010 | 20610306 |
| the tlr4/trif-mediated activation of nlrp3 inflammasome underlies endotoxin-induced liver injury in mice. | administration of heat-killed propionibacterium acnes renders mice highly susceptible to lps. after lps challenge p. acnes-primed mice promptly show hypothermia, hypercoagulation (disseminated intravascular coagulation), elevation of serum proinflammatory cytokine levels, and high mortality. the surviving mice develop liver injury. as previously reported, il-18 plays a pivotal role in the development of this liver injury. many cell types including macrophages constitutively store il-18 as biolog ... | 2010 | 20634907 |
| minocycline in acne vulgaris: benefits and risks. | minocycline is a semi-synthetic, second-generation tetracycline. it was introduced in 1972 and has both antibacterial and anti-inflammatory properties. minocycline is used for a variety of infectious diseases and in acne. even today, new indications beyond the antibacterial indications are being investigated such as its use in neurologic diseases. formerly, minocycline was thought to have a superior efficacy in the treatment of inflammatory acne, especially with respect to antibacterial-resistan ... | 2010 | 20642295 |
| efficacy of benzoyl peroxide (5.3%) emollient foam and benzoyl peroxide (8%) wash in reducing propionibacterium acnes on the back. | topical treatment of acne vulgaris on the back is challenging largely due to the extensive broad surface with difficult to reach areas. a "leave-on" foam is suited for application to the trunk due to ease of application and spreadability. prior to this trial, no data on propionibacterium acnes (p. acnes) reduction on the back has existed for any benzoyl peroxide (bp) formulations or other acne treatments. | 2010 | 20645523 |
| the development of antimicrobial resistance due to the antibiotic treatment of acne vulgaris: a review. | to review recent studies on the use of antibiotics in acne vulgaris which provide insight into the development of antimicrobial resistance. | 2010 | 20645527 |
| antibacterial activity of thai herbal extracts on acne involved microorganism. | ethyl acetate and methanol extracts of 18 thai medicinal plants were investigated for their antibacterial activity against propionibacterium acnes, stapylococcus aureus, and s. epidermidis. thirteen plant extracts were capable of inhibiting the growth of p. acnes and s. epidermidis, while 14 plant extracts exhibited an inhibitory effect on s. aureus. based on the broth dilution method, the ethyl acetate extract of alpinia galanga (l.) wild. (zingiberaceae) rhizome showed the strongest antibacter ... | 2010 | 20645714 |
| free radical scavenging and anti-acne activities of mangosteen fruit rind extracts prepared by different extraction methods. | the ethanol extracts of mangosteen fruit rinds prepared by several extraction methods were examined for their contents of bioactive compounds, dpph-scavenging activity, and anti-acne producing bacteria against propionibacterium acnes and staphylococcus epidermidis. the dried powder of the fruit rind was extracted with 95% ethanol by maceration, percolation, soxhlet extraction, ultrasonic extraction, and extraction using a magnetic stirrer. soxhlet extraction promoted the maximum contents of crud ... | 2010 | 20645837 |
| infected rathke cleft cysts: distinguishing factors and factors predicting recurrence. | rathke cleft cysts (rccs) are benign sellar lesions that are generally asymptomatic but sometimes warrant transsphenoidal drainage. small case reports have described infected rccs, but this phenomenon remains uncharacterized. | 2010 | 20651624 |
| activities of ten essential oils towards propionibacterium acnes and pc-3, a-549 and mcf-7 cancer cells. | ten essential oils, namely, mint (mentha spicata l., lamiaceae), ginger (zingiber officinale rosc., zingiberaceae), lemon (citrus limon burm.f., rutaceae), grapefruit (citrus paradisi macf., rutaceae), jasmine (jasminum grandiflora l., oleaceae), lavender (mill., lamiaceae), chamomile (matricaria chamomilla l., compositae), thyme (thymus vulgaris l., lamiaceae), rose (rosa damascena mill., rosaceae) and cinnamon (cinnamomum zeylanicum n. lauraceae) were tested for their antibacterial activities ... | 2010 | 20657472 |
| toll-like receptor (tlr)-9 genetics and function in sarcoidosis. | sarcoidosis is a systemic disorder characterized by the formation of non-caseating granulomas in variable organs. toll-like receptor (tlr)-9 is important in the innate immune response against both mycobacterium tuberculosis and propionibacterium acnes, candidate causative agents in sarcoidosis. the aim of our study was to investigate possible genetic and functional differences in tlr-9 between patients and controls. tlr-9 single nucleotide polymorphisms were genotyped in 533 patients and divided ... | 2010 | 20659127 |
| the clinical features of late onset acne compared with early onset acne in women. | little is known about the clinical characteristics of acne based on the age of onset. | 2011 | 20659307 |
| acne and diet: truth or myth? | numerous studies were published over the last 50 years to investigate whether diet is associated with the etiology of acne. although older studies well known by dermatologists that refute the association between acne and diet exist, their scientific foundation is weak. new articles have recently brought to light evidence contrary to previous findings. therefore, we would like to investigate whether diet, directly or indirectly, influences one or more of the four fundamental etiopathogenic pillar ... | 2010 | 20676468 |
| [microbial contamination of nipradiol with and without benzalkonium chloride]. | to compare microbial contamination of nipradiol both with and without benzalkonium chloride (bac). | 2010 | 20681256 |
| innate, antigen-independent role for t cells in the activation of the immune system by propionibacterium acnes. | propionibacterium acnes is a human commensal but also an opportunistic pathogen. in mice, p. acnes exerts strong immunomodulatory activities, including formation of intrahepatic granulomas and induction of lps hypersensitivity. these activities are dependent on p. acnes recognition via tlr9 and subsequent il-12-mediated ifn-gamma production. we show that p. acnes elicits il-12p40 and p35 mrna expression in macrophages, and ifn-gamma mrna in liver cd4(+) t cells and nk cells. after priming with p ... | 2010 | 20690177 |
| does inflammatory acne result from imbalance in the keratinocyte innate immune response? | acne is a multifactorial chronic disease affecting around 80% of teenage population. the pathogenesis of acne involves inflammatory reactions and colonization by the propionibacterium acnes (p. acnes) strain. p. acnes stimulates the keratinocytes involved in the innate immune response, the intensity of which could be influenced either by bacterial intrinsic factors or by endogenous factors of the host. | 2010 | 20691803 |
| protease-activated receptor-2 mediates the expression of inflammatory cytokines, antimicrobial peptides, and matrix metalloproteinases in keratinocytes in response to propionibacterium acnes. | propionibacterium acnes (p. acnes) has been known to produce various exogenous proteases, however, their role in acne pathogenesis remains largely unknown. proteases elicit cellular responses, at least in part, via proteinase-activated receptor-2 (par-2), which is known to mediate inflammation and immune response. in this study, we investigated whether proteases from p. acnes could activate par-2 on keratinocytes and induce pro-inflammatory cytokines, antimicrobial peptides (amps), and matrix me ... | 2010 | 20697725 |
| biopolymer scaffolds for use in delivering antimicrobial sophorolipids to the acne-causing bacterium propionibacterium acnes. | sophorolipids (sls) are known to possess antimicrobial properties towards many species (particularly gram-positive, or gram(+)) of bacteria. however, these properties can only be exerted if the sls can be introduced to the bacterial cells in an acceptable manner. propionibacterium acnes is the common bacterial cause of acne. it is a gram(+) facultative anaerobe that is susceptible to the antimicrobial effects of sls. in this study we demonstrated that different biopolymer matrices could be used ... | 2011 | 20708720 |
| sinogenic orbital and subperiosteal abscesses: microbiology and methicillin-resistant staphylococcus aureus incidence. | to assess the current bacteriology and the incidence of methicillin-resistant staphylococcus aureus in orbital and subperiosteal abscesses of paranasal sinus disease origin. | 2010 | 20723777 |
| expression of toll-like receptor 2 on peripheral blood monocytes of patients with inflammatory and noninflammatory acne vulgaris. | the pathogenesis of acne vulgaris is multifactorial and entails the interplay of hormonal, microbial and immunological events. the bacterium propionibacterium acnes is involved in the induction of comedogenesis and maintenance of the inflammatory phase of acne. toll-like receptor 2 (tlr2) expressed on mononuclear inflammatory cells and possibly on keratinocytes and sebocytes is thought to be of vital importance in mediating p. acnes-induced inflammatory response in acne vulgaris. this work aimed ... | 2009 | 20726329 |
| propionibacterium acnes and staphylococcus epidermidis isolated from refractory endodontic lesions are opportunistic pathogens. | the predominant cultivable microbiota from 20 refractory endodontic lesions (9 with abscesses and 11 without abscesses) were determined, and propionibacterium acnes and staphylococcus epidermidis were among the most predominant organisms. the number of species identified from lesions with abscesses (14.1 ± 2.6) was significantly greater (p < 0.001) than the number from lesions without abscesses (7.4 ± 5.9). comparison of perioral isolates using repetitive extragenic palindromic pcr of the same s ... | 2010 | 20739494 |
| proteomic identification of secreted proteins of propionibacterium acnes. | the anaerobic gram-positive bacterium propionibacterium acnes is a human skin commensal that resides preferentially within sebaceous follicles; however, it also exhibits many traits of an opportunistic pathogen, playing roles in a variety of inflammatory diseases such as acne vulgaris. to date, the underlying disease-causing mechanisms remain ill-defined and knowledge of p. acnes virulence factors remains scarce. here, we identified proteins secreted during anaerobic cultivation of a range of sk ... | 2010 | 20799957 |
| taurine bromamine (taubr)--its role in immunity and new perspectives for clinical use. | this review is an attempt to summarize our knowledge about taurine bromamine (taubr) properties, its role in innate immunity and its therapeutic potential.taubr and taurine chloramine (taucl) are major haloamines generated by eosinophils and neutrophils at a site of inflammation. both haloamines share anti-inflammatory and anti-oxidant properties. taubr, similarly to taucl, decreases the production of proinflammatory mediators. their anti-inflammatory and anti-oxidant activities are enhanced by ... | 2010 | 20804605 |
| population genetic analysis of propionibacterium acnes identifies a subpopulation and epidemic clones associated with acne. | the involvement of propionibacterium acnes in the pathogenesis of acne is controversial, mainly owing to its dominance as an inhabitant of healthy skin. this study tested the hypothesis that specific evolutionary lineages of the species are associated with acne while others are compatible with health. phylogenetic reconstruction based on nine housekeeping genes was performed on 210 isolates of p. acnes from well-characterized patients with acne, various opportunistic infections, and from healthy ... | 2010 | 20808860 |
| effects of two commercially available immunostimulants on leukocyte function of foals following ex vivo exposure to rhodococcus equi. | the objective of this study was to determine the effect of immunostimulants on neutrophil, macrophage, and lymphocyte function following ex vivo exposure to rhodococcus equi. eighteen foals were randomly assigned to one of 3 treatment groups. treatment consisted of inactivated propionibacterium acnes (pa), inactivated parapoxvirus ovis (ppvo), or saline (control) administered on days 0 (7 days of age), 2, and 8. bronchoalveolar lavage (bal) fluid and blood were collected on days 0 (baseline), 12 ... | 2010 | 20822815 |
| the potential use of echinacea in acne: control of propionibacterium acnes growth and inflammation. | acne is a chronic inflammatory disorder of skin follicles caused by the gram-positive bacterium propionibacterium acnes. the possibility was investigated that a standardized preparation of echinacea purpurea (echinaforce®), with known antiviral, antiinflammatory and antibacterial properties, might provide a useful alternative treatment in the control of the disease. the herbal extract readily killed a standard laboratory strain of the bacterium and several clinical isolates. in cell culture mode ... | 2011 | 20830697 |
| activity of an antimicrobial hydrocephalus shunt catheter against propionibacterium acnes. | shunt infection is a major complication affecting approximately 10% of procedures. propionibacterium acnes, an anaerobic skin bacterium, is increasingly recognized as a shunt pathogen, causing up to 14% of infections. though susceptible to penicillin and cephalosporins, p. acnes shunt infections are not preventable by means of perioperative prophylaxis, due to poor cerebrospinal fluid penetration. antimicrobial shunts with activity against staphylococci are available, but their activity against ... | 2010 | 20837763 |
| bilateral clavicle fracture external fixation. | fractures of the middle third of the clavicle are frequent and their conservative treatment ends in bone union in nearly 95% of cases. surgical treatment is unanimously indicated with open fractures or in cases of cutaneous damage, neurovascular complications, and impaction of the shoulder stump syndromes. we report herein a case of bilateral fractures of the clavicle that required double stabilization with an external fixator following major cutaneous damage appearing after the initial conserva ... | 2010 | 20850405 |
| mutagenesis of propionibacterium acnes and analysis of two camp factor knock-out mutants. | p. acnes is a skin commensal that is frequently associated with inflammatory diseases such as acne vulgaris. despite the availability of the genome sequence functional studies on p. acnes are scarce due to a lack of methods for genetic manipulation of this bacterium. here we present an insertional mutagenesis approach for the inactivation of specific p. acnes genes. the gene of interest can be disrupted and replaced with an erythromycin-resistance cassette by employing homologous recombination. ... | 2010 | 20850482 |
| apical root canal microbiota as determined by reverse-capture checkerboard analysis of cryogenically ground root samples from teeth with apical periodontitis. | bacteria located in the apical root canal system potentially participate in the pathogenesis of apical periodontitis. detection and identification of apical bacteria can be compromised because of limitations in conventional sampling and identification procedures. this study identified several bacterial taxa in the apical and middle/coronal segments of primarily infected root canal system by using pulverized root segments and a culture-independent molecular method. | 2010 | 20850664 |
| isolation of a novel bacteriophage specific for the periodontal pathogen fusobacterium nucleatum. | fusobacterium nucleatum is a periodontal pathogen that has been directly associated with the development and progression of periodontal disease, a widespread pathology that affects the support tissues of the tooth. we isolated a new bacteriophage (fnpφ02) that specifically infects this bacterium. transmission electron microscopy showed that the virion is composed of an icosahedral head and a segmented tail. the size of the phage genome was estimated to be approximately 59 kbp of double-stranded ... | 2010 | 20851973 |
| [evaluating post-cataract surgery changes in bacterial culture tests with and without face-washing]. | to evaluate the changes in conjunctiva and eyelid culture test results before and after cataract surgery and their relation to face-washing. | 2010 | 20865920 |
| development of a nondestructive fluorescence-based enzymatic staining of microcolonies for enumerating bacterial contamination in filterable products. | develop a nondestructive fluorescence-based staining procedure to rapidly detect and enumerate bacteria in filterable samples. | 2010 | 20880209 |
| photodynamic therapy in the management of acne: an update. | acne, one of the most common dermatological diseases, is characterized by inflammatory and noninflammatory lesions that may progress to scars. starting from pubertal age groups, it can affect adults in the age group 35-40 or more. the conventional therapies for treatment of acne are facing roadblocks because of the antibiotic resistance developing against propionibacterium acnes. this has led to trying new therapies, of which photodynamic therapy (pdt) seems to be the one under intensive study. ... | 2010 | 20883294 |
| propionibacterium acnes activates the igf-1/igf-1r system in the epidermis and induces keratinocyte proliferation. | propionibacterium acnes has a major role in the development of acne lesions. igf-1 stimulates the proliferation of keratinocytes via an activation of the igf-1 receptor (igf-1r). zinc has been proven to work efficiently against inflammatory acne and to modulate the igf-1 system. our objectives were to study the modulation of igf-1 and igf-1r expression by p. acnes extracts and to determine their modulation by zinc gluconate. in vivo, we analyzed biopsies of acne lesions and healthy skin, and in ... | 2010 | 20927124 |
| in vitro antimicrobial susceptibility of propionibacterium acnes isolated from acne patients in northern mexico. | antimicrobials are essential in acne therapy. in the last decades, propionibacterium acnes has become resistant to different antibiotics. | 2010 | 20931669 |
| prevalence of propionibacterium acnes in diseased prostates and its inflammatory and transforming activity on prostate epithelial cells. | prostate cancer (pca) is the second leading cause of male cancer deaths in the western world. mounting evidence has revealed that chronic inflammation can be an important initiating factor of pca. recent work has detected the anaerobic gram-positive bacterium propionibacterium acnes in cancerous prostates, but with wide-ranging detection rates. here, using in situ immunofluorescence (isif), p. acnes was found in 58 out of 71 (81.7%) tested cancerous prostate tissue samples, but was absent from h ... | 2010 | 20943438 |
| the taxonomic position of corynebacterium acnes. | 1946 | 20994865 | |
| bacterial contamination of needles used for intravitreal injections: a prospective, multicenter study. | to determine the incidence of bacterial contamination of needles used for intravitreal injections. | 2010 | 21034310 |
| mis416, a non-toxic microparticle adjuvant derived from propionibacterium acnes comprising immunostimulatory muramyl dipeptide and bacterial dna promotes cross-priming and th1 immunity. | propionibacterium acnes was modified using biochemical extraction methods generating a suspension of microparticles (mis416) comprising a minimal cell wall skeleton rich in immunostimulatory crosslinked muramyl dipeptide repeats and native bacterial dna fragments, each which have known adjuvant activity. in vitro studies demonstrated that mis416 was readily internalized by human myeloid and plasmacytoid dc inducing cytokine secretion and cell activation/maturation. vaccination studies in mice us ... | 2010 | 21034827 |
| detection of microbial contaminants in mammalian cell cultures using a new fluorescence-based staining method. | microbial contamination of cell culture production processes is a current concern for biopharmaceutical industries. traditional testing methods require several days to detect contamination and may advantageously be replaced by a rapid detection method. we developed a new method combining membrane filtration to microcolonies fluorescence staining method (mfsm) and compared it to epifluorescence microscopy. | 2010 | 21039669 |
| efficacy and safety of combined ethinyl estradiol/drospirenone oral contraceptives in the treatment of acne. | acne is a common disorder affecting the majority of adolescents and often extends into adulthood. the central pathophysiological feature of acne is increased androgenic stimulation and/or end-organ sensitivity of pilosebaceous units leading to sebum hypersecretion and infundibular hyperkeratinization. these events lead to propionibacterium acnes proliferation and subsequent inflammation. hormonal therapy, including combined oral contraceptives (ocs), can attenuate the proximate androgenic trigge ... | 2010 | 21072290 |
| benzoyl peroxide: enhancing antibiotic efficacy in acne management. | benzoyl peroxide is one of the most widely used topical agents for acne. it has potent antibacterial and mild anti-inflammatory and comedolytic effects. to treat mild to moderate acne, it can be used alone or in combination with topical antibiotics and topical retinoids. the combination of benzoyl peroxide with either erythromycin or clindamycin is synergistic and well-tolerated. in more severe acne, when oral antibiotics are required, benzoyl peroxide can contribute to suppressing the emergence ... | 2010 | 21076800 |
| potent antimicrobial action of triclosan-lysozyme complex against skin pathogens mediated through drug-targeted delivery mechanism. | triclosan (tcs), an antimicrobial agent that inhibits bacterial fatty acid synthesis by blocking the active site of enoyl-acp reductase (fabi), is a water-insoluble agent that limits its therapeutic candidacy. we have recently shown that the water solubility and antimicrobial activity of tcs were greatly enhanced when complexed to lysozyme (lz). this study is to examine the therapeutic potential of triclosan-lysozyme (t-lz) complex against common skin pathogens expressing different levels of fab ... | 2010 | 21078387 |
| staphylococcus aureus hijacks a skin commensal to intensify its virulence: immunization targeting β-hemolysin and camp factor. | the need for a new anti-staphylococcus aureus therapy that can effectively cripple bacterial infection, neutralize secretory virulence factors, and lower the risk of creating bacterial resistance is undisputed. here, we propose what is, to our knowledge, a previously unreported infectious mechanism by which s. aureus may commandeer propionibacterium acnes, a key member of the human skin microbiome, to spread its invasion and highlight two secretory virulence factors (s. aureus β-hemolysin and p. ... | 2010 | 21085191 |
| fluorescence diagnostic imaging in patients with acne. | orange-red fluorescence in the follicle openings, induced by ultraviolet a light, originates from porphyrins, the metabolic products of propionibacteria acnes. | 2010 | 21091785 |
| [pathophysiological advances in acne]. | acne is a chronic disorder caused by multiple factors. recent advances suggest that inflammation plays an initial role and propionibacterium acnes plays a major role by initiating, maintaining and extending acne. | 2010 | 21095495 |
| a review of the safety and efficacy of benzoyl peroxide (5.3%) emollient foam in the management of truncal acne vulgaris. | this article reviews findings of studies regarding the treatment of truncal acne with benzoyl peroxide formulations and, in particular, studies utilizing a 5.3% benzoyl peroxide foam. its formulation of micronized benzoyl peroxide particles in an emollient foam vehicle offers significant clinical and bioavailability advantages that enhance follicular penetration and skin moisturization. a key consideration for topical management of truncal acne is whether the treatment application method allows ... | 2010 | 21103313 |
| tlr2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes. | a diverse environment challenges skin to maintain temperature, hydration, and electrolyte balance while also maintaining normal immunological function. rosacea is a common skin disease that manifests unique inflammatory responses to normal environmental stimuli. we hypothesized that abnormal function of innate immune pattern recognition could explain the enhanced sensitivity of patients with rosacea, and observed that the epidermis of patients with rosacea expressed higher amounts of toll-like r ... | 2010 | 21107351 |
| proteomics integrated with escherichia coli vector-based vaccines and antigen microarrays reveals the immunogenicity of a surface sialidase-like protein of propionibacterium acnes. | proteomics is a powerful tool for the identification of proteins, which provides a basis for rational vaccine design. however, it is still a highly technical and time-consuming task to examine a protein's immunogenicity utilizing traditional approaches. here, we present a platform for effectively evaluating protein immunogenicity and antibody detection. a tetanus toxin c fragment (tet-c) was used as a representative antigen to establish this platform. a cell wall-anchoring sialidase-like protein ... | 2008 | 21136919 |
| bacteriologic culture of excised intervertebral disc from immunocompetent patients undergoing single level primary lumbar microdiscectomy. | study design: a consecutive case series from a single center of patients undergoing primary microdiscectomy for lumbar herniated nucleus pulposus (hnp) who received microbiologic laboratory culture of excised disc material. objective: to determine the prevalence of positive bacterial cultures in the disc material of immunocompetent patients without diabetes mellitus or other immune compromise. summary of background data: the intradiscal space is a physiologically tenuous environment in terms of ... | 2010 | 21150662 |
| recombinant lactobacilli expressing linoleic acid isomerase can modulate the fatty acid composition of host adipose tissue in mice. | we have previously demonstrated that oral administration of a metabolically active bifidobacterium breve strain, with ability to form cis-9, trans-11 conjugated linoleic acid (cla), resulted in modulation of the fatty acid composition of the host, including significantly elevated concentrations of c9, t11 cla and omega-3 (n-3) fatty acids in liver and adipose tissue. in this study, we investigated whether a recombinant lactobacillus expressing linoleic acid isomerase (responsible for production ... | 2010 | 21178166 |
| synthesis and antimicrobial activity of long-chain 3,4-epoxy-2-alkanones. | 3,4-epoxy-2-dodecanone, a major component in the preorbital gland of the african grey duiker (sylvicapra grimmia), showed antimicrobial activity in preliminary tests. the c(11) to c(17) homologues of this compound were prepared and their activity against several pathogenic dermal bacteria and fungi was tested. 3,4-epoxy-2-dodecanone and 3,4-epoxy-2-tridecanone inhibited the growth of trichophyton mentagrophytes at 25 îg/ml. moderate inhibition of the growth of the bacteria propionibacterium acne ... | 2010 | 21179314 |
| treating acne in women. | 2010 | 21214119 | |
| efficacy of an anaerobic swab transport system to maintain aerobic and anaerobic microorganism viability after storage at -80 degrees c. | an amies agar gel swab transport system was evaluated for its ability to maintain bacterial viability and relative quantity after freezing at -80°c. nine american type culture collection (atcc) bacterial strains were used: 3 anaerobic strains (propionibacterium acnes, peptostreptococcus anaerobius, and clostridium sporogenes) and 6 facultative or strict aerobic bacterial strains (stenotrophomonas maltophilia, escherichia coli ([atcc 25922 and atcc 11775], salmonella enterica subsp. enterica sero ... | 2011 | 21217035 |
| what is the role of benzoyl peroxide cleansers in acne management?: do they decrease propionibacterium acnes counts? do they reduce acne lesions? | 2008 | 21218192 | |
| comparison of the in vivo antimicrobial effectiveness of sodium hypochlorite and chlorhexidine used as root canal irrigants: a molecular microbiology study. | the purpose of this clinical study was to compare the antimicrobial effects of 2.5% sodium hypochlorite (naocl) and 0.12% chlorhexidine digluconate (chx) when used as irrigants during treatment of teeth with apical periodontitis. | 2011 | 21238793 |
| propionobacter acnes infection as an occult cause of postoperative shoulder pain: a case series. | infections after shoulder surgery are potentially devastating complications. propionibacterium acnes is recognized as a causal agent in shoulder infections. the clinical presentation is usually insidious and nonspecific, but a p. acnes infection could be an occult cause of postoperative shoulder pain. | 2011 | 21240577 |
| interactions between various microbes and ginseng botanicals. | three kinds of interactions occur between ginseng botanicals and microorganisms: a) spoilage of the botanical by various fungi (e.g., aspergillus, penicillium, alternaria, and eurotium species) and bacteria; b) transformation of ginsenosides into more bioactive forms by bacteria such as intrasporangium sp. gs603, microbacterium sp. gs514, caulobacter leidyia, bifidobacterium sp. int57, bifidobacterium sp. sj32, fusobacterium sp. and bacteroides sp., and moulds (e.g., aspergillus niger, fusarium ... | 2011 | 21254831 |
| propionibacterium acnes vaccination induces regulatory t cells and th1 immune responses and improves mouse atopic dermatitis. | atopic dermatitis (ad) is a chronic disease characterized by a polarized th2 immune response. propionibacterium acnes (p. acnes) has been shown to elicit strong th1 immune responses. we hypothesized that the host immune response to p. acnes will prevent the development of ad. to demonstrate this hypothesis, we investigated the effect of p. acnes vaccination on ad that occurs in keratin 14/driven caspase-1 transgenic mouse. vaccination with low dose of p. acnes successfully prevented clinical man ... | 2011 | 21255097 |
| new approaches in light/laser therapies and photodynamic treatment of acne. | acne is a domain in which the technology and understanding of light/laser therapeutic procedures have advanced considerably. the aim of the paper was to revisit adjunctive physical treatments of acne, including light/laser treatments and photodynamic therapy. this review summarizes findings about such treatment modalities with particular emphasis on efficacy and safety. a number of laser/light-based modalities have been developed to meet the increasing demand for new acne treatments. the current ... | 2011 | 21269242 |
| efficacy of oral antibiotics on acne vulgaris and their effects on quality of life: a multicenter randomized controlled trial using minocycline, roxithromycin and faropenem. | there are few clinical studies which compare the efficacy and patient satisfaction for oral antibiotics to treat inflammatory acne. to clarify the difference between oral antibiotics, acne patients with moderate to severe inflammatory eruptions were randomized into three groups, and each patient was given minocycline (mino), roxithromycin (rxm) or faropenem (frpm) for 4 weeks, followed by 4 weeks of observation without any oral antibiotics. we estimated the reduction rate of inflammatory lesion ... | 2010 | 21269305 |
| blockade of th1 chemokine receptors ameliorates pulmonary granulomatosis in mice. | sarcoidosis is a granulomatous disease of unknown aetiology. we identified immunological targets for the treatment of pulmonary granulomatosis using a murine model generated with propionibacterium acnes. sensitisation and challenge using heat-killed p. acnes and dendritic cells (dcs) were performed to produce pulmonary granulomatosis in c57bl/6 mice. immunological analyses using elisa as well as cdna microarray analysis were used to search for cytokines or chemokines associated with the formatio ... | 2011 | 21273392 |
| randomized tolerability analysis of clindamycin phosphate 1.2%-tretinoin 0.025% gel used with benzoyl peroxide wash 4% for acne vulgaris. | the multiple etiologic factors involved in acne vulgaris make the use of several medications necessary to treat the condition. use of a fixed combination of clindamycin phosphate 1.2% and tretinoin 0.025% in conjunction with a benzoyl peroxide (bpo) wash 4% targets several pathologic factors simultaneously and mitigates the potential for clindamycin-induced propionibacterium acnes-resistant strains. new formulations may allow such regimens to be effectively used without overly reduced tolerabili ... | 2010 | 21284283 |
| phenelfamycins g and h, new elfamycin-type antibiotics produced by streptomyces albospinus acta 3619. | phenelfamycins g and h are new members of the family of elfamycin antibiotics with the basic structure of phenelfamycins e and f, respectively, which are also well known as ganefromycins a and ß. phenelfamycins g and h differ from phenelfamycins e and f by an additional hydroxy group at position c-30, which is not described so far for any of the elfamycin-type antibiotics. the actinomycete strain that produced phenelfamycins g and h was identified to be streptomyces albospinus based on its 16s r ... | 2011 | 21285962 |
| large thoracomyoplasty and negative pressure therapy for late postpneumonectomy empyema with a retrosternal abscess: a modern version of the clagett procedure. | a 63-year-old male with a history of cancer, and who had undergone a left pneumonectomy seven years before, presented with deterioration in his general status and recent dyspnea [stage iii (new york heart association) nyha]. imaging revealed a contralateral mediastinal shift and cardiac compression caused by pneumonectomy cavity enlargement and a retrosternal liquid mass. late empyema associated with a retrosternal abscess caused by propionibacterium acnes was diagnosed after thoracoscopy and an ... | 2011 | 21303873 |
| late capsular block syndrome associated with propionibacterium acnes. | 2011 | 21320976 | |
| clinical significance of propionibacterium acnes recovered from blood cultures: analysis of 524 episodes. | of 522 patients with propionibacterium acnes bacteremia (pab), 18 (3.5%) had clinically significant pab. of these 18 patients, 10 (55.6%) had hospital-acquired bacteremia and 6 (33.3%) had undergone invasive procedures before development of pab. one patient with a ventricular septal defect presented with infective endocarditis. after the exclusion of 1 patient whose outcome was not available, the overall mortality rate was 5.9% (1/17). | 2011 | 21325550 |
| in vivo antimicrobial effects of endodontic treatment procedures as assessed by molecular microbiologic techniques. | this culture-independent molecular microbiology study evaluated the antimicrobial effects of chemomechanical preparation supplemented by intracanal medication during treatment of teeth with apical periodontitis. | 2010 | 21329812 |
| identification, typing and characterisation of propionibacterium strains from healthy mucosa of the human stomach. | forty two propionibacterium isolates were recovered from biopsy samples of the gastric mucosa of eight out of 12 healthy people. of these, 41 were identified as belonging to propionibacterium acnes; the remaining isolate was identified as belonging to propionibacterium granulosum. repetitive extragenic palindromic (rep)-pcr typing suggested that up to four strains might be present in the mucosa of the same individual. sequence analysis of either reca, tly or camp5 genes of p. acnes isolates reve ... | 2011 | 21329995 |
| resveratrol-containing gel for the treatment of acne vulgaris: a single-blind, vehicle-controlled, pilot study. | acne vulgaris is a complex, chronic, and common skin disorder of pilosebaceous units. the major pathogenic factors involved are ductal hyperkeratinization, obstruction of sebaceous follicles resulting from abnormal keratinization of the infundibular epithelium, stimulation of sebaceous gland secretion by androgens, and microbial colonization of pilosebaceous units by propionibacterium acnes, which promotes perifollicular inflammation. | 2011 | 21348544 |
| normal human epidermal keratinocytes react differently than hacat keratinocyte cell line on exposure to propionibacterium acnes. | 2010 | 21352277 | |
| comparative study of the bactericidal effects of 5-aminolevulinic acid with blue and red light on propionibacterium acnes. | propionibacterium acnes naturally produces endogenous porphyrins that are composed of coproporphyrin iii (cpiii) and protoporphyrin ix (ppix). red light alone and photodynamic therapy (pdt) improve acne vulgaris clinically, but there remains a paucity of quantitative data that directly examine the bactericidal effects that result from pdt on p. acnes itself in vitro. the purpose of this study was to measure the difference of bactericidal effects of 5-aminolevulinic acid (ala)-pdt with red and bl ... | 2010 | 21352326 |
| antibiotic susceptibility of propionibacterium acnes isolated from acne vulgaris in korea. | propionibacterium acnes plays an important role in the development of acne, and inflammatory lesions are improved by antibiotics. long-term use of antibiotics may result in development of resistant strains and treatment failure. the aim of the present study was to investigate the isolation rate of p. acnes and to evaluate its antibiotic susceptibility to widely used antibiotics in acne in korea. among 46 patients, 31 p. acnes strains were cultured. isolated p. acnes was measured for minimum inhi ... | 2010 | 21352337 |
| passive immunoprotection targeting a secreted camp factor of propionibacterium acnes as a novel immunotherapeutic for acne vulgaris. | propionibacterium acnes (p. acnes) bacteria play a key role in the pathogenesis of acne vulgaris. although our previous studies have demonstrated that vaccines targeting a surface sialidase or bacterial particles exhibit a preventive effect against p. acnes, the lack of therapeutic activities and incapability of neutralizing secretory virulence factors motivate us to generate novel immunotherapeutics. in this study, we develop an immunotherapeutic antibody to secretory christie-atkins-munch-pete ... | 2011 | 21354482 |
| treating acne with antibiotic-resistant bacterial colonization. | introduction: acne is a chronic skin disorder of the pilosebaceous unit; it has a multifactorial pathogenesis. propionibacterium acnes within the follicle is considered to be a triggering factor of inflammation in acne. antibiotics have been the primary treatment against p. acnes for more than 40 years. however, a gradual increase in the prevalence of antibiotic-resistant strains of p. acnes has been observed. areas covered: this review discusses the pathophysiology of antibiotic-resistant acne ... | 2011 | 21355786 |
| impact of monocytic cells on recovery of uncultivable bacteria from atherosclerotic lesions. | abstract. rafferty b, jönsson d, kalachikov s, demmer rt, nowygrod r, elkind msv, bush jr h, kozarov e. (columbia university medical center, new york, ny; and weill cornell medical college, new york, ny; usa) impact of monocytic cells on recovery of uncultivable bacteria from atherosclerotic lesions. j intern med 2011; 270: 273-280. objective. epidemiological evidence suggests that infections may contribute to atherogenesis. however, with the exception of chlamydophila pneumoniae, cultivable b ... | 2011 | 21366733 |
| clinical significance of positive cranial bone flap cultures and associated risk of surgical site infection after craniotomies or craniectomies. | the risk of surgical site infection (ssi) after craniotomies or craniectomies in patients in whom contaminated bone flaps have been reimplanted has not been determined. the objectives of this study were to identify the prevalence of bone flaps with positive cultures--especially those contaminated with propionibacterium acnes--to assess the risk of ssi after reimplanting (either during the initial operation or subsequently) bone flaps with positive cultures, and to identify risk factors for ssi f ... | 2011 | 21375380 |
| effect of propionibacterium acnes-containing immunostimulant on interferon-gamma (ifn+¦) production in the neonatal foal. | production of the th1 cytokine interferon gamma (ifn+¦) is associated with resistance to intracellular pathogens, including rhodococcus equi. while neonatal foals are initially deficient in ifn+¦ production, expression of this cytokine increases throughout their first year of life. this is presumably the result of stimulation by environmental antigens including pathogen associated molecular patterns (pamps) signaling through toll-like receptors (tlr). this increased expression of ifn+¦ is likewi ... | 2011 | 21382640 |
| oral antibiotic therapy for acne vulgaris: pharmacokinetic and pharmacodynamic perspectives. | objective: to review data on pharmacokinetic factors that influence the absorption and tissue distribution for individual antibiotic agents to better inform clinicians on rational dosing considerations of oral antibiotics for the treatment of acne vulgaris. the focus is placed on the most commonly prescribed oral antibiotics for acne vulgaris, the tetracyclines. dose-response is also reviewed. design and methods: this review describes factors affecting the absorption, distribution, and target ti ... | 2011 | 21386956 |
| recent trends in specular light reflectance beyond clinical fluorescence diagnosis. | under specific light illumination, particularly ultraviolet (uv) and near-uv light stimulation, the skin produces both specular light reflectance and, possibly, specific fluorescent emission. these properties offer diagnostic clues and disclose some peculiar functions of the skin. a series of superficial infections (erythrasma, some tinea capitis types, tinea/pityriasis versicolor, dermatophytoses, etc.) and pilosebaceous follicles enriched in propionibacterium spp show fluorescence. this latter ... | 2011 | 21411414 |
| indole-3-acetic acid: a potential new photosensitizer for photodynamic therapy of acne vulgaris. | ala (5-aminolevulinic acid) photodynamic therapy (pdt) is a new treatment option for acne. however, it needs a relatively long incubation period and adverse effects are common. indole-3-acetic acid (iaa) is not toxic by itself but produces free radicals with ultraviolet b. in this study we examined the potential of iaa as a photosensitizer for acne treatment. | 2011 | 21412803 |
| medical microbiology | the microorganisms discussed in this chapter are taxonomically unrelated. the human infections they cause are rare except in the case of listeria and propionibacterium acnes. some of these infections are fatal; others tend to be self-limited. recognition depends largely on the proper use of bacteriological methods, which is important not only to ensure appropriate therapy but also to exclude other possible agents ... | 1996 | 21413274 |