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vwa+ phenotype of yersinia enterocolitica.expression of the vwa+ phenotype of yersinia pestis in vitro is known to reflect maximum induction of virulence (or v and w antigens) at 37 degrees c with concomitant restriction of cell division. both phenomena are potentiated by 20 mm mg2+ and prevented by cultivation at 26 or 37 degrees c with 2.5 mm ca2+. we have now compared this classic plasmid-mediated phenotype with those of vwa+ yersinia pseudotuberculosis and yersinia enterocolitica which, unlike y. pestis, produce ancillary outer memb ...19836832830
cross-resistance to fecal excretion of yersinia enterocolitica in mice by oral vaccination of killed cells.mice vaccinated orally with heat-killed cells of serovar o3 of yersinia enterocolitica were protected only against fecal excretion of the homologous serovar, whereas formalin-killed cells provided cross-protection against serovar o9 and vice versa. serovar iva of yersinia pseudotuberculosis, when formalin-killed, also provided cross-protection against y. enterocolitica. on the other hand, serratia liquefaciens and serovar o6 strains did not furnish cross-protection.19836852921
scarlatiniform rash and pleural effusion in a patient with yersinia pseudotuberculosis infection. 19836854452
fecal excretion associated with ca2+ dependency of yersinia enterocolitica o3 and o9 and yersinia pseudotuberculosis in mice. 19836865806
[incorporation of radioactive precursors into the lipopolysaccharide-protein complex from yersinia pseudotuberculosis]. 19836865808
[presence of anti-yersinia pseudotuberculosis agglutinins during a flare-up of ileal crohn's disease. apropos of 3 cases].sera of 19 patients who had been admitted with an attack of crohn's disease were tested for agglutinins against yersinia. the localization and the extent of the disease were highly variable. only three patients with a subacute obstruction syndrome due to ileitis had a high circulating antibody titer directed against yersinia pseudotuberculosis type iv (greater than or equal to 1/500). culture of the stools did not isolate any pathogenic organisms; particularly, yersinia pseudotuberculosis failed ...19836873577
[enteropathy with loss of proteins associated with the presence of anti-yersinia pseudotuberculosis agglutinins]. 19836873588
interaction between yersinia pseudotuberculosis and the hela cell surface.the adherence of yersinia pseudotuberculosis to the surface of hela cells at 4 degrees c was studied. this temperature allows adhesion of bacteria but prevents engulfment. adhesion between the bacteria and the cells was not dependent upon the presence of serum, ca2+ or mg2+ in the medium. maximum adhesion was obtained at ph 6.5-7.9 and pretreatment of the cells with formaldehyde or glutaraldehyde inhibited the attachment of the bacteria. the interaction between the bacteria and the cell surface ...19836876136
polyarthritis from yersinia pseudotuberculosis: a british case of 'far-eastern scarlatiniform fever'? 19836886457
ingestion of yersinia pseudotuberculosis into human fibroblasts in vitro.the ingestion into human fibroblasts of different strains (avirulent and virulent) of yersinia pseudotuberculosis was investigated. the kinetics of ingestion was studied with the addition of 10(7) bacteria to human lung fibroblast cultures. the number of ingested bacteria after 0.5-3 h was measured with viable count technique. all strains were ingested except for one avirulent strain. the other strains were ingested at roughly the same rate. the bacterial uptake seemed to be mediated by a phagoc ...19806937977
yersinia arthritis in children.over a 10-year period 37 children were hospitalized with infections of yersinia enterocolitica iii, ix or yersinia pseudotuberculosis ia. the diagnosis was based on elevated antibody titres against these micro-organisms. thirteen of the children had reactive arthritis caused by yersinia. the duration of arthritis in the primary phase varied between 3 and 22 months, the average being 6.5 months. two patients developed persistent arthritis. chemical synovectomy with osmic acid was performed in 3 c ...19806969933
yersinia pseudotuberculosis: use of cold-temperature enrichment for isolation.the successful isolation of yersinia pseudotuberculosis from the stool of an asymptomatic family member of a patient with yersinia septicemia is presented. cold enrichment permitted the isolation after 4 weeks of refrigerator incubatio,.19806986399
alkali method for rapid recovery of yersinia enterocolitica and yersinia pseudotuberculosis from foods.a new culture method employing a potassium hydroxide treatment was compared with the conventional cold enrichment method for efficacy in recovering yersinia sp. from naturally and artificially contaminated food. the new method increased the yield of yersinia sp. fourfold and the sensitivity 100-fold, shortened the incubation period, and appreciably decreased the growth of non-yersinia bacteria from a variety of meats, shellfish, and vegetables.19806986846
[body autosensitization in pseudotuberculous infection]. 19806988644
[pathology of yersinia infections].at the present time yersinioses have turned from a comparatively small problem of regional pathology into a global problem of interest for large circles of medical workers, specialists in different fields. the paper presents the main clinico-anatomic forms of yersiniosis and still scarce data on their pathology. these diseases, as a rule, have a benign course, their lethality not exceeding 0.04%. the importance of studying their pathology is emphasized because the correct diagnosis helps avoid s ...19806998427
[abdominal form of pseudotuberculosis simulating acute appendicitis]. 19806999223
[massive intestinal bleeding caused by yersinia pseudotuberculosis (author's transl)].a disease in a male 47 year old caused by yersinia pseudotuberculosis is discussed. his fever was not responding to chloramphenicol, cephalosporine and gentamycin. during the disease a perilous gastrointestinal haemorrhage appeared. symptoms according to an acute septic enterocolitis were observed.19806999761
[routes for the spread of the pseudotuberculosis microbe, y. pseudotuberculosis, in infection foci]. 19807000625
[chief results of far eastern scarlatina-like fever (epidemic pseudotuberculosis) research]. 19807001798
[yersinia pseudotuberculosis polyarthritis]. 19807003686
[isolation of yersinia pseudotuberculosis from fresh water fish in the primor'e krai]. 19807003991
[psychrophilic properties of the pseudotuberculosis microbe and their importance to the epidemic process in far eastern scarlatina-like fever]. 19807003996
seroreactions in detecting yersinia enterocolitica and yersinia pseudotuberculosis in the gdańsk region, years 1973-1976. 19807004551
yersinia pseudotuberculosis infection in a group of macaca fascicularis.diarrheal disease associated with abortions and stillbirths occurred in a group of 42 macaca fascicularis. the group was composed of wild-caught adults and their colony-born offspring housed in a half-acre cage. thirteen adult females and 1 infant male were affected. all 14 monkeys had diarrhea and all 9 pregnant females either aborted or had a stillbirth. yersinia pseudotuberculosis was isolated from 7 animals. in addition, y enterocolitica was isolated from 1 monkey and shigella flexneri type ...19807005202
fatal yersinia pseudotuberculosis infection in captive bushbabies.fatal yersinia pseudotuberculosis infection was diagnosed in 3 bushbabies (galago crassicaudatus) in a large prosimian colony. the clinical signs were diarrhea, dyspnea, hyperthermia, dehydration, and lethargy. histologically, the disease was characterized by lesions of ulcerative enterocolitis, necrotizing hepatitis, splenitis, lymphadenitis, and nonsuppurative pneumonitis.19807005203
in vitro antimicrobial sensitivity of isolates of yersinia pseudotuberculosis from deer. 19807005768
[clinical and immunological characteristics of the course of pseudotuberculous mixed infection associated with other diseases]. 19807008235
[use of glucocorticoids in severe forms of pseudotuberculosis]. 19807009979
[yersinia pseudotuberculosis simulating acute appendicitis in a child]. 19807010265
[histology and differential diagnosis of yersinia pseudotuberculosis-ileitis]. 19807010343
[protracted forms of pseudotuberculosis in the far east]. 19817013143
rapid diagnostic test that uses isocitrate lyase activity for identification of yersinia pestis.the presence of high levels of isocitrate lyase activity in yersinia pestis grown on blood agar base medium, as compared with low levels of this enzyme in yersinia pseudotuberculosis and yersinia enterocolitica, suggested that the differences in the levels of this enzyme could be used for the presumptive identification of y. pestis. a modified, semiquantitative assay for isocitrate lyase activity is described which requires no expensive instrumentation, utilizes readily available chemicals and s ...19817014615
liver abscess complicating yersinia pseudotuberculosis ileitis.the occurrence of solitary liver abscess is described in a young farmer with subacute terminal ileitis mimicking crohn's disease. serologic tests showed high titers of antibodies for yersinia pseudotuberculosis. treatment with troleandomycin was successful. this case report suggests that: (a) yersinia infection must be systematically searched for in all forms of subacute ileitis; (b) a classically benign yersinia ileitis may be complicated by liver abscess; (c) antibiotic therapy must be underta ...19817016657
mesenteric lymphadenitis due to yersinia pseudotuberculosis: a case report. 19817019789
[a little known form of aseptic arthritis: due to yersinia pseudotuberculosis. apropos of a case, review of the literature]. 19817020058
[aseptic arthritis with positive serology for yersinia pseudotuberculosis. apropos of 6 new cases].six personal observations of aseptic acute arthritis with positive serology for yersinia pseudotuberculosis (ypt) have been related, the specific serodiagnosis was clearly positive (greater than 1/500) for all the patients and the rate variations of repeated examinations were constantly observed. these cases have been compared with 14 sporadic observations of the existing studies where such reactive arthritis were referred to a recent ypt infection, this confrontation leads us to specify the cha ...19817020061
yersinia pseudotuberculosis as the cause of septicaemia in a patient with liver cirrhosis. a case report.septicaemia caused by yersinia pseudotuberculosis in a female patient, aged 22, is reported. she had suffered from a chronic active hepatitis for 14 years and had been treated with corticosteroids and azathioprine. the y. pseudotuberculosis septicaemia responded well to treatment with doxycycline orally, but the patient died 2 weeks later because of excessive bleeding from varicose veins of the oesophagus.19817020342
[yersinia pseudotuberculosis (rodentiosis) in poland 1966-1978]. 19817022399
[effectiveness of antibacterial therapy of pseudotuberculosis]. 19817023029
yersinia pseudotuberculosis septicemia. report of a case. 19807023076
[immunoglobulins and their specific activity in far eastern scarlatina-like fever]. 19817023139
[determination of the subtypes of y. pseudotuberculosis isolated from patients with far eastern scarlatina-like fever in the primorskii krai]. 19817023149
[stimulation of nonspecific body resistance by mytilan, a polysaccharide isolated from the mussel. crenomytilis grayanus].the results of the study on the immunostimulant effect of mytilan, a polysaccharide isolated from crenomytilus grayanus inhabiting the sea of japan are presented. it was shown that a single dose of the drug administered parenterally stimulated the natural protective reactions of the macroorganism evident from an increase in the leukocyte count in the peripheral blood of the experimental animals and the phagocytic activity of polymorphonuclear nuclear leukocytes. mytilan stimulated humoral immuni ...19817023374
[yersinia pseudotuberculosis type ii causing acute gastroenteritis with skin manifestations and polyarthritis (author's transl)]. 19807024693
[human infection by yersinia enterocolitica and pseudotuberculosis in spain. analysis of 80 recent cases]. 19817025130
[latent and subclinical forms of pseudotuberculosis. allergological diagnosis, bacterial carrier state and incidence]. 19817025327
[erythema nodosum in pseudotuberculosis infection]. 19817025448
[diagnosis of pseudotuberculosis]. 19817025449
[protective antigen of the pseudotuberculosis microbe].proteinolipopolysaccharide (plps) isolated from the causative agent of pseudotuberculosis has the properties of a protective antigen. it protects 86-90% of mice and guinea-pigs from lethal y. pseudotuberculosis infection (20 lethal doses) and stimulates humoral and cellular immunity factors, as well as the phagocytic activity of monocytes. it is of particular importance due to the fact that in y. pseudotuberculosis infection the system of mononuclear phagocytes plays a significant role in elimin ...19817025531
[cardiovascular system in yersiniasis]. 19817026883
[differential diagnosis of icteric forms of pseudotuberculosis and viral hepatitis]. 19817027166
[fiessinger-leroy-reiter syndrome associated with a positive serology for yersinia pseudotuberculosis]. 19817029703
[another case of aseptic arthritis during yersinia pseudotuberculosis infection]. 19817029704
[myopathy in fattened turkeys caused by yersinia pseudotuberculosis (author's transl)]. 19817030690
reiter's disease and yersinia pseudotuberculosis infection. 19817031244
[clinical manifestations of mixed variant of pseudotuberculosis]. 19817031957
[epidemiological importance of yersinia transmission routes and factors in pseudotuberculosis foci]. 19817032057
[yersinia-arthritis in childhood (author's transl)]. 19817033769
[water and aquatic organisms as the host of yersinia pseudotuberculosis]. 19817036598
[acute yersinia pseudotuberculosis arthritis. 2 new cases]. 19817038832
[clinical laboratory characteristics of the jaundice form of pseudotuberculosis]. 19807038991
[frequency and significance of infections due to yersinia enterocolitica in "acute appendicitis" (author's transl)].in 352 patients who were hospitalized with symptoms of an acute appendicitis, yersinia infection were determined in 18.2% of the cases by cultural and serological methods. infections due to y. enterocolitica (y. e.) serovar 0:3 were approximately 6 times more frequent than those due to y. e. serovar 0:9. yersinia pseudotuberculosis (y. pstbc.) could only be isolated in one patient from a mesenterial lymph node. in another case yersinia serovar 0:6 could be isolated as well as y. e. serovar 0:3. ...19827039157
caprine mastitis associated with yersinia pseudotuberculosis infection. 19827043883
[cellular reactions of increased delayed sensitivity in human pseudotuberculosis].a total of 145 patients having far eastern scarlatiniform fever, 99 healthy persons and 54 patients with diseases of non-pseudotuberculous etiology have been examined by means of fradkin's neutrophil damage test, the capillary cell migration inhibition test and the intradermal test. the specific transformation of the cellular immunity system has been shown to occur in scarlatiniform fever. this transformation takes the form of delayed type hypersensitivity reaction. the immunological tests used ...19827043971
[prophylactic aspects of human pseudotuberculosis].for the first time the effectiveness of the complex of preventive measures carried out in the foci of human pseudotuberculosis in evaluated. it has been shown that one can control the disease, prevent group infections and outbreaks by simple sanitary and hygienic measures, such as following the rules of culinary technology and excluding raw vegetables from the diet, thus interrupting the main routes of infection transfer. these measures have proved to be effective even when the causative agent i ...19827043981
[uveitis in a yersinia pseudotuberculosis infection--one case]. 19827049434
[yersinia pseudotuberculosis infection]. 19827050825
[antibiotic sensitivity of yersinia enterocolitica and yersinia pseudotuberculosis isolated from patients with the jaundice form of acute hepatitis].sensitivity to 12 antibiotics of y. enterocolitica and y. pseudotuberculosis isolated from patients with acute hepatitis in the jaundice form was studied. it was found that the representatives of y. enterocolitica markedly differed from the strains of y. pseudotuberculosis by their sensitivity to penicillins: the mic for the first was greater than 1600 micrograms/ml and for the latter it was 0.1--3.2 micrograms/ml. among the aminoglycosides gentamicin proved to be the most active against both sp ...19827059145
prevalence of o agglutinins against the epizootic strains of yersinia pseudotuberculosis serovars ib and iva in barn rats. 19827109417
the application of 13c-nmr spectroscopy to study lipid a from yersinia pseudotuberculosis lipopolysaccharide.the use of 13c-nmr spectroscopy in the establishment of lipid a backbone structure from lipopolysaccharide of yersinia pseudotuberculosis has been described. the 13c-nmr spectra of degraded lipid a and its n-acetate were obtained. the assignment of signals was made by comparison with the chemical shifts for 13c-nmr spectra of glucosaminitol, n-acetyl-glucosaminitol and their beta-1,4 and beta-1,6 disaccharides. it was shown that lipid a backbone of the lipopolysaccharide in question consists of ...19827128594
[biological activity of lysozymes of various origins].the in vitro and in vivo studies showed that lysozymes obtained from o. papillipes, o moubata, a. lahorensis and h. asiaticum had bacteriostatic and bactericidal effects. the effect of the lysozymes obtained from the above ticks was studied in comparison to that of the egg lysozyme. micrococci, staphylococci, streptococci, e. coli and c. diphtheriae proved to be the most sensitive. salmonella, listeria, pasteurella pseudotuberculosis and pasteurella tularensis were less sensitive. the comparison ...19827149682
[subacute enterocolitis associated with the presence of anti-yersinia pseudotuberculosis agglutinins (3 cases)]. 19827152213
isolation and serotyping of yersinia pseudotuberculosis in humans in japan. 19827160372
[seasonal isolation of yersinia enterocolitica and yersinia pseudotuberculosis from tonsils of healthy slaughter pigs (author's transl)].45 strains of yersinia (y.) enterocolitica from which 36 respectively 9 belonged to o-group i or v and 28 strains of y. pseudotuberculosis from which 15 respectively 13 isolates belonged to serotype i or ii were isolated from 70 tonsils of 480 examined, clinically healthy slaughter pigs. in the tonsils of three animals were found both species together. y. enterocolitica was isolated during the whole year, but especially in the months of november (17.5%) and december (32.5%). y. pseudotuberculosi ...19817198363
[action of pesticides on pseudotuberculosis microbes (yersinia pseudotuberculosis)]. 19817203053
[wissler-fanconi syndrome or polyarthritis caused by yersinia pseudotuberculosis?]. 19817208327
test and teach. number twenty-six. diagnosis: yersinia pseudotuberculosis acute mesenteric lymphadenitis. 19817220096
mesenteric lymphadenitis due to yersinia enterocolitica.the histopathological diagnosis of yersinia enterocolitica infections in mesenteric lymph nodes is described on the basis of biopsy material from 14 cases collected at the lymph node registry in kiel. in all cases, the aetiological diagnosis was verified by demonstrating significant antibody titres in serological tests and, in two cases, by isolating yersinia enterocolitica from faeces. the mesenteric lymph nodes showed a rather specific histological picture. in all cases, the capsule was thicke ...19817222465
occurrence of yersinia enterocolitica in wild animals.yersinia species were isolated from 16 of 495 small wild animals and from 1 of 38 foxes. the animals were trapped in seven regions of hokkaido, japan. of the 17 strains isolated, 9 were yersinia enterocolitica o6; 2 were y. enterocolitica o5a; 1 was y. enterocolitica, o4; 1 was y. enterocolitica o9; 1 was yersinia pseudotuberculosis ivb; and 3 were sucrose-negative strains. yersinia pestis was not isolated. the o6 organism was most prevalent in large red-back mice (clethrionomys rufocanus bedfor ...19817224628
[occurrence of human pathogenic yersinia enterocolitica and yersinia enterocolitica and yersinia pseudotuberculosis in slaughter animals]. 19817225050
yersinia and viruses in acute non-specific abdominal pain and appendicitis.four out of 24 patients presenting as an emergency with acute non-specific abdominal pain showed serological evidence of infection with yersinia pseudotuberculosis. two out of 13 patients presenting with acute appendicitis during the same period also had evidence of yersinia infection. viral infection was present in only 1 patient in each group. since it is rare to find antibodies to yersinia in healthy individuals, it seems likely that yersinia is a cause of some cases of non-specific abdominal ...19817225744
isolation of yersinia pseudotuberculosis from diarrhoea in pigs. 19817225783
yersinia pseudotuberculosis infection: study of an epizootic in squirrel monkeys.an epizootic of an acutely fatal enteric disease in a colony of squirrel monkeys (saimiri sciureus) was attributed to infection by yersinia pseudotuberculosis serotype iii. of a total adult population of 96 animals at risk, there were six fatal cases of yersiniosis. serological evaluation of the colony just after the outbreak ended revealed that 22 of 60 monkeys tested (37%) had significant antibody to y. pseudotuberculosis (microagglutination titer of greater than or equal to 1:80) but did not ...19817240387
[isolation of yersinia pseudotuberculosis and yersinia enterocolitica from patients with acute hepatitis of the icteric type]. 19817245950
[radioactive precursor incorporation into yersinia pseudotuberculosis cells]. 19817311899
incidence of yersiniosis in finland.during 1971 through 1978 antibodies against yersinia enterocolitica types 3 and 9 and yersinia pseudotuberculosis ia were measured in 25307 patients with symptoms compatible with yersinia infections in southwestern finland. agglutinin titres greater than or equal to 160 were found in 1 500 patients. the annual incidence of elevated titres varied, but no significant overall change was found during this period. the results suggest that yersiniosis is not a "new" infection with increasing incidence ...19817313586
[demonstration of yersinia enterocolitica and yersinia pseudotuberculosis in fecal samples of healthy slaughter swine depending on the season]. 19817324640
structural studies on the o-specific polysaccharide side-chains of yersinia pseudotuberculosis, type iii, lipopolysaccharides.lipopolysaccharide from pathogenic yersinia pseudotuberculosis type iii, strain 209, has been isolated and characterized. lipopolysaccharide was shown to contain lipid a (30%), protein (4.4%), 2-keto-3-deoxyoctonate (7.8%) and a polysaccharide component (45%), which consisted of paratose, l-fucose, d-mannose, d-glucose, d-galactose (trace), l- and d-glycero-d-manno-heptose, 2-deoxy-2-amino-d-glucose and 2-deoxy-2-amino-d-galactose residues. molecular -sieve chromatography on sephadex g-50 afford ...19807398633
plague virulence antigens from yersinia enterocolitica.the virulence of yersinia enterocolitica, biotype 2, serotype o:8, in mice is related to its ability to produce plague v and w antigens. v and w antigens in y. enterocolitica are shown to be immunologically identical to the previously described v and w antigens of yersinia pestis and yersinia pseudotuberculosis.19807399681
peptidoglycan from yersinia pseudotuberculosis: isolation and general characterization.a peptidoglycan layer of y. pseudotuberculosis cell wall was isolated from cells after treatment with sodium dodecylsulphate and digestion with pronase. the isolated peptidoglycan contained glucosamine, muramic acid, alanine, glutamic acid and diaminopimelic acid in the approximate molar ratio of 1:0.8:2:1:1.19807421603
[yersinia pseudotuberculosis ileitis (bacillus malassez and vignal) with complications]. 19807443509
[dynamics of the humoral immune response to the lipopolysaccharide-protein complex of yersinia pseudotuberculosis]. 19807445865
[serodiagnosis of human yersinia infections. preliminary results].preliminary data are reported on experience with newly developed complement-fixing (cf) antigens prepared from cultures of type 3 and type 9 yersinia enterocolitica and from yersinia pseudotuberculosis. antigens were immunologically potent and not anti-complementary, thus making it possible to obtain satisfactory serologic tests. the results may be summarized as follows: 1. yersinia cf antigens do not react with sera from healthy blood donors. there was only one low titer reaction with type 9 an ...19807455648
the chaperone-like protein yera of yersinia pseudotuberculosis stabilizes yope in the cytoplasm but is dispensible for targeting to the secretion loci.the virulence plasmid-encoded yope cytotoxin of yersinia pseudotuberculosis is secreted across the bacterial membranes and subsequently translocated into the eukaryotic cell. translocation of yope into target cells was recently shown to be polarized and only occurred at the zone of contact between the pathogen and the eukaryotic cell. immunogold electron microscopy on cryosectioned y. pseudotuberculosis revealed that yope is secreted and deposited on the bacterial cell surface when the bacteria ...19957476159
acute renal failure associated with yersinia pseudotuberculosis infection.since 1987, we have experienced 11 children with acute renal failure (arf) associated with yersinia pseudotuberculosis (yp) infection. the illness began with the sudden onset of high fever, skin rash and gastrointestinal symptoms. later in the course, periungual desquamation developed, mimicking kawasaki disease. elevated erythrocyte sedimentation rate, c-reactive protein and thrombocytosis were noticeable, and mild degrees of proteinuria, glycosuria and sterile pyuria were common. arf, which ty ...19957477620
[a case of lesniowski-crohn disease preceded by yersinia pseudotuberculosis infection].in etiopathogenesis of leśniowski-crohn disease we consider environmental genetical, immunological and physical factors. among the bacteria that are of importance in a disease process there are: jarsinia, tubercle bacillus and para- tubercle bacillus. we are to state that the pro.... of the bacteria per se doesn't influence the initiation of a disease. the initiation is caused by a change of the immune response. the introduced case shows the occurrence of leśniowski-crohn disease proceeded by ja ...19947483629
lack of antibody response to invasin in humans with yersiniosis.the yersinia pseudotuberculosis inv gene encodes invasin, a 103-kda outer membrane protein allowing bacteria to penetrate mammalian cells. this protein is produced in vitro at below 30 degrees c. in this work, we studied the antibody response against invasin in humans suffering from yersiniosis and in mice orally infected with a virulent strain of y. pseudotuberculosis. infection with enteropathogenic yersinia strains did not induce either a systemic or a gut antibody response to invasin. our re ...19947496952
isolation and identification of eukaryotic receptors promoting bacterial internalization. 19947526128
salmonella typhimurium induces selective aggregation and internalization of host cell surface proteins during invasion of epithelial cells.salmonella interact with eucaryotic membranes to trigger internalization into non-phagocytic cells. in this study we examined the distribution of host plasma membrane proteins during s. typhimurium invasion of epithelial cells. entry of s. typhimurium into hela epithelial cells produced extensive aggregation of cell surface class i mhc heavy chain, beta 2-microglobulin, fibronectin-receptor (alpha 5 beta 1 integrin), and hyaluronate receptor (cd-44). other cell surface proteins such as transferr ...19947527051
an aspartate residue of the yersinia pseudotuberculosis invasin protein that is critical for integrin binding.the yersinia pseudotuberculosis invasin protein mediates bacterial entry into mammalian cells by binding multiple beta 1-chain integrins. invasin binding to purified alpha 5 beta 1 integrin is inhibited by arg-gly-asp (rgd)-containing peptides, although invasin contains no rgd sequence. fifteen mutations that diminished binding and bacterial entry were isolated after mutagenesis of the entire inv gene. all of the mutations altered residues within the c-terminal 192 amino acids of invasin, previo ...19957532130
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