Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| [assessment of human papilloma virus (hpv) testing in primary screening for cervical cancer in france (may 2004)]. | 2005 | 15999430 | |
| surgical smoke and infection control. | gaseous byproducts produced during electrocautery, laser surgery or the use of ultrasonic scalpels are usually referred to as 'surgical smoke'. this smoke, produced with or without a heating process, contains bio-aerosols with viable and non-viable cellular material that subsequently poses a risk of infection (human immunodeficiency virus, hepatitis b virus, human papillomavirus) and causes irritation to the lungs leading to acute and chronic inflammatory changes. furthermore, cytotoxic, genotox ... | 2006 | 16002179 |
| incomplete inhibition of the rb tumor suppressor pathway in the context of inactivated p53 is sufficient for pancreatic islet tumorigenesis. | here, we describe the surprising residual capability of the rb pathway to negatively regulate proliferation and tumorigenesis in a sv40 large t antigen (tag)-driven mouse model of pancreatic islet carcinogenesis. heterogeneous tag expression during all progression stages suggested that a threshold level of the t antigen oncoprotein might be deterministic for beta-cell hyperproliferation and led us to hypothesize that tag might not be fully inhibiting the tumor suppressor activity of rb. moreover ... | 2005 | 16007165 |
| epidemiological study in okinawa, japan, of human papillomavirus infection of the uterine cervix. | to investigate the prevalence and type distribution of human papillomavirus (hpv) in women with normal cervical cytology and with cervical intraepithelial neoplasia i to iii(cin) or carcinoma of the cervix in okinawa, japan. | 2005 | 16011997 |
| knowledge of cervical cancer and screening among women in east-central england. | this study assesses the extent and accuracy of women's knowledge of cervical cancer, risk factors, and the efficacy of the national screening program. data were obtained from a questionnaire survey of randomly selected women eligible for screening, drawn from a population in east-central england. the majority of women in the sample overestimated the current incidence of cervical cancer, both absolutely and relative to other cancers. perceiving incidence to be high was associated with reporting w ... | 2005 | 16014118 |
| [relations between the expression of cyclin e, p16ink4, ki67 and hpv16/18 infection in cervical exfoliated cells]. | to confirm the relations between the expression of cyclin e, p16ink4, ki67 and hpv16/18 infection using cervical exfoliated cells, and evaluate the usefulness of cyclin e, p16ink4 and ki67 as biomarkers for screening of cervical carcinomas. | 2005 | 16027780 |
| laser capture microdissection and pcr for analysis of human papilloma virus infection. | human papilloma virus (hpv) infection is considered one of the main factors involved in the pathogenesis of endocervical adenocarcinoma. however, the cellular location of hpv in this type of tumor is controversial. we have developed a method to determine the presence of hpv type 16 in endocervical cancer cells using laser capture microdissection followed by dna extraction and qualitative polymerase chain reaction. our results show that hpv type 16 is present in endocervical adenocarcinoma cells. | 2005 | 16028428 |
| human papillomavirus type 16 infections and 2-year absolute risk of cervical precancer in women with equivocal or mild cytologic abnormalities. | the 2-year absolute risk for cervical precancer attributable to infection by human papillomavirus type 16 (hpv16), the most common and oncogenic hpv type, in the millions of women diagnosed annually with equivocal or mildly abnormal cytology has not been definitively evaluated. | 2005 | 16030304 |
| the elevated 10-year risk of cervical precancer and cancer in women with human papillomavirus (hpv) type 16 or 18 and the possible utility of type-specific hpv testing in clinical practice. | human papillomavirus (hpv) types 16 and 18 cause 60%-70% of cervical cancer worldwide, and other hpv types cause virtually all remaining cases. pooled hpv testing for 13 oncogenic types, including hpv16 and 18, is currently used in clinical practice for triage of equivocal cytology and, in conjunction with pap tests, is an option for general screening among women 30 years of age and older. it is not clear to what extent individual identification of hpv16 or hpv18 as an adjunct to pooled oncogeni ... | 2005 | 16030305 |
| presence and type of oncogenic human papillomavirus in classic and in differentiated vulvar intraepithelial neoplasia and keratinizing vulvar squamous cell carcinoma. | the presence and type of oncogenic papillomavirus (hpv) in classic warty/basaloid vulvar intraepithelial neoplasia and in differentiated vulvar intraepithelial neoplasia and keratinizing vulvar squamous cell carcinoma was investigated using three techniques, that is, histology, in situ hybridization, and pcr-elisa. hpv typing was performed using in situ hybridization and pcr-elisa. differentiated vulvar intraepithelial neoplasia and invasive keratinizing vulvar squamous cell carcinoma proved com ... | 2005 | 16032717 |
| candidate human papillomavirus (hpv) type 27b: nucleotide sequence and heterogeneity with hpv 27. | more than 100 human papillomavirus (hpv) types have been reported as tumorigenic agents. hpv types 2 and 27 were identified in benign tumors and classified closely according to the sequence homology. an hpv type 2 related sequence was identified previously in an oral papilloma. however, the correct typing and sequencing was impossible at that time. a candidate hpv was cloned by the long-pcr technique from an oral papilloma and characterized by nucleotide sequence. this virus was basically hpv ty ... | 2005 | 16032718 |
| detection of human papillomavirus (hpv) 16-specific cd4+ t-cell immunity in patients with persistent hpv16-induced vulvar intraepithelial neoplasia in relation to clinical impact of imiquimod treatment. | topical application of the immune response modifier imiquimod is an alternative approach for the treatment of human papillomavirus (hpv)-positive vulvar intraepithelial neoplasia (vin) and aims at the immunologic eradication of hpv-infected cells. we have charted hpv16-specific immunity in 29 patients with high-grade vin and examined its role in the clinical effect of imiquimod treatment. | 2005 | 16033846 |
| activation of the protein kinase b pathway by the hpv-16 e7 oncoprotein occurs through a mechanism involving interaction with pp2a. | protein kinase b (pkb) or akt is one of several second messenger kinases that are activated by cell attachment and growth factor signaling, and that transmit signals to the cell nucleus to inhibit apoptosis and thereby increase cell survival during proliferation. other viral proteins target this pathway by increasing pkb/akt phosphorylation, and this pathway has been implicated in the transformation of human keratinocytes by hpv e6 and e7, together with activated notch 1. here, we examine how hp ... | 2005 | 16044149 |
| hpv infection in adolescents: natural history, complications, and indicators for viral typing. | human papillomavirus (hpv) is the most common sexually transmitted disease in both men and women. prevalence rates are the highest for adolescents. despite the high prevalence rates, sequelae of genital warts, dysplasia, and cancer are rare developments. knowledge about the natural history, virology, and cancerous transformation has lead to improved viral detection, including the use of hpv dna detection tests, screening efforts for hpv-related precancerous and cancerous lesions, and clinical in ... | 2005 | 16044390 |
| proposed sheffield quantitative criteria in cervical cytology to assist the grading of squamous cell dyskaryosis, as the british society for clinical cytology definitions require amendment. | in 1986, the british society for clinical cytology (bscc) published quantitative criteria to assist diagnosis in a three-tier grading system of squamous cell dyskaryosis. in dyskaryotic cells, area nuclear to cytoplasmic (nc) ratios below 50%, between 50% and 66% and over 66% were defined as equating with mild, moderate and severe grades respectively. following the terminology conference in 2002, however, the bscc recommended on their website that the three-tier model should be replaced by a new ... | 2005 | 16048504 |
| transcutaneous immunization in mice: induction of t-helper and cytotoxic t lymphocyte responses and protection against human papillomavirus-induced tumors. | previous reports have shown that transcutaneous immunization (tci) with proteins or peptides in combination with adjuvants efficiently induces specific cellular and humoral immune responses. however, depending on the kind of skin pretreatment, induction of cellular immune responses was restricted to generation of either specific cytotoxic t lymphocytes (ctls) or t-helper (th) cells. in this study, we induced antigen-specific ctl responses together with the appropriate th responses by tci of c57b ... | 2006 | 16052529 |
| requirement of epidermal growth factor receptor for hyperplasia induced by e5, a high-risk human papillomavirus oncogene. | multicellular organisms rely on complex networks of signaling cascades for development, homeostasis, and responses to the environment. these networks involve diffusible signaling molecules, their receptors, and a variety of downstream effectors. alterations in the expression or function of any one of these factors can contribute to disease, including cancer. many viruses have been implicated in cancer, and some of these modulate cellular signal transduction cascades to carry out their life cycle ... | 2005 | 16061632 |
| association of the human papillomavirus type 16 e7 oncoprotein with the 600-kda retinoblastoma protein-associated factor, p600. | the human papillomavirus type 16 (hpv-16) e7 gene encodes a multifunctional oncoprotein that can subvert multiple cellular regulatory pathways. the best-known cellular targets of the hpv-16 e7 oncoprotein are the retinoblastoma tumor suppressor protein prb and the related pocket proteins p107 and p130. however, there is ample evidence that e7 has additional cellular targets that contribute to its transforming potential. we isolated hpv-16 e7 associated cellular protein complexes by tandem affini ... | 2005 | 16061792 |
| anal cytology: is there a role for reflex hpv dna testing? | there is an increased incidence of anal squamous carcinoma and its precursor lesions (anal intraepithelial neoplasia [ain]) among persons who engage in anal-receptive sex. analogous to cervical cancer screening, anal papanicplaou (pap) smears currently are used to screen these high-risk populations. human papilloma virus (hpv) has been implicated in anal carcinoma pathogenesis and this study was performed to assess the potential role of hpv dna testing as an adjunct to anal cytology. we correlat ... | 2005 | 16078257 |
| concordance of specific human papillomavirus types in sex partners is more prevalent than would be expected by chance and is associated with increased viral loads. | genital human papillomavirus (hpv) infections are generally accepted to be sexually transmitted, but studies of hpv infections in sex partners are limited. we investigated hpv type-specific concordance and viral load in 238 heterosexual couples. women with cervical intraepithelial neoplasia were the index patients in these couples. | 2005 | 16080082 |
| concordance of human papillomavirus (hpv) type between sex partners: implications for effective utilization of an hpv vaccine. | 2005 | 16080083 | |
| risk factors for hpv infection and cervical cancer among unscreened women in a high-risk rural area of china. | we report a prevalence rate of 23.6% human papillomavirus (hpv) infection with oncogenic subtypes and 2.4% cervical intraepithelial neoplasia (cin) iii and cervical cancer (cc) in rural middle-aged women in 2 counties with the highest cc mortality in shanxi province, china. we examined the association of risk factors to hpv infection and to cin iii and cc in 8,798 unscreened women aged 35-50 years. multivariate odds ratios (or) and 95% confidence intervals (ci) for each endpoint were obtained fo ... | 2006 | 16080192 |
| p53 intronic g13964c variant in colon cancer and its association with hpv. | inactivation of p53 is the most common change identified in human cancer. nucleotide alterations in p53 intron 6 have been reported to be associated with the dysregulation of p53 function and tumor development. the aim of our study was to assess whether the intron 6 g13964c variant of the p53 gene is associated with the presence of human papillomavirus (hpv) as a risk factor in colon cancer. | 2005 | 16080524 |
| the biological role of smoking, oral contraceptive use and endogenous sexual steroid hormones in invasive squamous epithelial cervical cancer. | for at least twenty years, epidemiological studies have found a correlation between cervical neoplasia and smoking and oral contraceptives. over the last ten years, laboratory evidence has supported epidemiological findings. one example is the addition of progesterone to human papillomavirus-transfected cervical cells, which has led to oncogenic cell transformation. very high concentrations of tobacco constituents in cervical mucus, as compared to serum, in smokers provided evidence of a biologi ... | 2005 | 16080563 |
| expression of human papillomavirus type 16 l1 in baculovirus expression systems: a case study. | 2005 | 16082027 | |
| optimization and validation of a multiplexed luminex assay to quantify antibodies to neutralizing epitopes on human papillomaviruses 6, 11, 16, and 18. | a human papillomavirus (hpv) multiplexed competitive luminex immunoassay first described by opalka et al. (d. opalka, c. e. lachman, s. a. macmullen, k. u. jansen, j. f. smith, n. chirmule, and m. t. esser, clin. diagn. lab. immunol. 10:108--15, 2003) was optimized and validated for use in epidemiology studies and vaccine clinical trials. optimization increased both the analytical sensitivity and the clinical specificity of the assay to more effectively discriminate the low-titer antibody respon ... | 2005 | 16085914 |
| human papilloma virus papilloma masquerading as adenoid hypertrophy. | 2005 | 16087035 | |
| human papillomavirus-related cervical and anal disease in hiv-infected individuals in the era of highly active antiretroviral therapy. | hiv-infected men who have sex with men remain at high risk of developing anal cancer despite the widespread use of highly active antiretroviral therapy (haart). in hiv-infected women, however, there is some evidence that haart may be associated with regression of human papillomavirus (hpv)-related cervical disease. so far, epidemiologic data provided by cancer registries have shown no reduction in the incidence of cervical and anal cancer in patients with hiv infection since the initiation of ha ... | 2005 | 16091261 |
| aerodigestive cancers in hiv infection. | aerodigestive (lung, head and neck) cancers are among the most prevalent and deadly neoplasms worldwide, and the incidence rates are rising. given the improvements in life expectancy of persons with hiv/aids when treated with highly active antiretroviral agents, persons with hiv infection are therefore increasingly likely to develop these malignancies. this chapter focuses on the epidemiology of these malignancies and reviews the most recent literature and current understanding of the causes and ... | 2005 | 16093799 |
| the utility of hpv dna triage in the management of cytological agc. | given the demonstrated utility of human papilloma virus dna triage in the management of atypical squamous cells of undetermined significance, this study sought to evaluate the potential role of human papilloma virus dna testing in the evaluation and management of cytological atypical glandular cells. | 2005 | 16098895 |
| differential splicing of e6 within human papillomavirus type 18 variants and functional consequences. | persistent infections of the uterine cervix with 'high-risk' human papillomavirus (hpv) are now recognized as necessary for the development of cervical cancer. among them, hpv types 16 and 18 exhibit numerous variants associated with different risks for cervical cancer development. in this study, the questions of whether different hpv type 18 variants exhibit changes in early gene transcription and the molecular mechanisms underlying these differences were investigated. it was shown that, indeed ... | 2005 | 16099904 |
| loss of 10p material in a child with human papillomavirus-positive disseminated bilateral retinoblastoma. | retinoblastoma (rb) is a malignant childhood tumor that results from loss or inactivation of both alleles of the rb1 gene. human papillomavirus (hpv) dna sequences have been found in rb tissue, suggesting a role of the viral infection with rb. we here describe a child with disseminated bilateral rb without familial history, who displayed a loss of material from 10p. fluorescence in situ hybridization studies showed a somatic loss of both alleles of the rb1 gene. moreover, sequences for hpv-6a we ... | 2005 | 16102585 |
| [evaluation of search for human papillomavirus (hpv) during cervical precancer and cancer screening: synopsis and perspectives (may 2004)]. | 2005 | 16108114 | |
| parental acceptance of the human papillomavirus vaccine. | we conducted focus groups and individual interviews to explore parental views on the human papillomavirus (hpv) vaccine. parents were generally positive about the hpv vaccine. some participants perceived their children were not at risk for acquiring hpv and questioned vaccinating young adolescents against hpv. vaccine education should target parental beliefs about hpv and the optimal age for hpv vaccine administration. | 2005 | 16109349 |
| immunotherapy with ctl peptide and vssp eradicated established human papillomavirus (hpv) type 16 e7-expressing tumors. | peptide-based vaccines aimed at the induction of effective t-cell responses against established tumors have not been successful in clinic and require the use of new adjuvants. one of those is a new adjuvant in which gangliosides are incorporated into the outer membrane protein complex of neisseria meningitidis to form very small size proteoliposomes (vssp). in a preclinical model of human papillomavirus hpv16-induced cervical cancer we show that vaccination with hpv 16 e7 derived minimal ctl pep ... | 2005 | 16112257 |
| tissue distribution of human papillomavirus 16 dna integration in patients with tonsillar carcinoma. | human papillomavirus 16 (hpv-16) has been implicated as a causative agent in a subset of head and neck squamous cell carcinomas (hnscc). this study was undertaken to discern the distribution and timing of hpv viral integration during tumorigenesis of the upper respiratory tract. | 2005 | 16115905 |
| profiling estrogen-regulated gene expression changes in normal and malignant human ovarian surface epithelial cells. | estrogens regulate normal ovarian surface epithelium (ose) cell functions but also affect epithelial ovarian cancer (oca) development. little is known about how estrogens play such opposing roles. transcriptional profiling using a cdna microarray containing 2400 named genes identified 155 genes whose expression was altered by estradiol-17beta (e2) in three immortalized normal human ovarian surface epithelial (hose) cell lines and 315 genes whose expression was affected by the hormone in three es ... | 2005 | 16116479 |
| immunotherapy for gynaecological malignancies. | gynaecological malignancies, excluding breast cancer, cause approximately 25,000 deaths yearly among women in the us. therefore, novel approaches for the prevention or treatment of these diseases are urgently required. in the case of cervical cancer, human papillomavirus (hpv) xenoantigens are readily recognised by the immune system, and their targeting has shown great promise in preclinical models of therapeutic vaccination and in clinical studies of preventative vaccination. a growing body of ... | 2005 | 16120050 |
| epidemiologic correlates of cervical human papillomavirus prevalence in women with abnormal pap smear tests: a taiwan cooperative oncology group (tcog) study. | to explore factors affecting human papillomavirus (hpv) prevalence in all grades of cervical neoplasia among chinese women, 1,264 women with abnormal cervical cytology attending the gynaecologic clinics of 11 major medical centres in taiwan. patients were interviewed and underwent complete gynaecologic examination including colposcopy. cervical scrapings were collected for hpv dna detection by both hybrid capture-2 (high-risk probe) and l1 consensus pcr-reverse line blot. the prevalences of hpv ... | 2005 | 16121376 |
| the p53 codon 72 polymorphism and risk of high-grade cervical intraepithelial neoplasia. | the arg/arg genotype versus arg/pro or pro/pro at codon 72 of the p53 gene has been implicated in increasing susceptibility of the cervix to human papillomavirus (hpv) infection and thus altering cancer risk. however, research on this topic has been contentious, which prompted us to carry out a case-control study in the montreal area. | 2005 | 16122882 |
| p53 mutations and human papillomavirus infection in oral squamous cell carcinomas: correlation with overall survival. | the study investigated the pattern of p53 gene mutations and human papillomavirus (hpv) infection concerning their relation to overall survival in patients with oral squamous cell carcinomas of the tongue and floor of the mouth. | 2005 | 16129609 |
| anal cancer in renal transplant patients. | a comprehensive literature review was performed to examine the prevalence of anal cancer, anal intraepithelial neoplasia (ain) and anal human papillomavirus (hpv) infection in renal transplant recipients who are at risk of anal cancer due to iatrogenic immunosuppression. | 2007 | 16133005 |
| atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion: diagnostic performance, human papillomavirus testing, and follow-up results. | current guidelines recommend colposcopy rather than high-risk human papillomavirus (hpv) testing for the evaluation of abnormal cervical cytology interpreted as "atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion" (asc-h) based on data from the atypical squamous cells of undetermined significance/low-grade squamous intraepithelial lesion (ascus/lsil) triage study (alts), which indicated that asc-h had a significantly greater frequency of high-risk hpv positivity a ... | 2006 | 16136595 |
| [a case of dandy-walker malformation futus and 18-trisomy]. | 2004 | 16136993 | |
| viral oncoprotein-induced mislocalization of select pdz proteins disrupts tight junctions and causes polarity defects in epithelial cells. | the development of human cancers is frequently associated with a failure of epithelial cells to form tight junctions and to establish proper apicobasal polarity. interestingly, the oncogenic potential of the adenovirus e4-orf1 protein correlates with its binding to the cellular pdz proteins mupp1, magi-1, zo-2 and sap97, the first three of which assemble protein complexes at tight junctions. given that e4-orf1 sequesters these three pdz proteins in the cytoplasm of fibroblasts, we postulated tha ... | 2005 | 16141229 |
| human papillomavirus vaccines and adolescents. | this review will describe human papillomavirus (hpv) vaccines in development, summarize data regarding safety and efficacy of these vaccines, and discuss key issues related to hpv vaccine implementation. | 2005 | 16141761 |
| [usefulness of searching for human papillomavirus (hpv): evaluation of screening practices for precancerous lesions of the uterine cervix]. | 2005 | 16142172 | |
| dna vaccines based on chimeric potyvirus-like particles carrying hpv16 e7 peptide (aa 44-60). | vaccine strategies for the treatment of human papillomavirus-induced cervical cancer are based mainly on the human papillomavirus 16 e7 (hpv16 e7) oncoprotein. the immunogenicity of the e7 gene has been enhanced by its fusion to many different genes. here, we linked a short sequence coding for the e7 peptide (aa 44-60) containing immunodominant epitopes for b and t cells to the 3' end of the gene coding for the whole coat protein (cp) of the poty-virus, potato virus a (pva), and its deleted form ... | 2005 | 16142370 |
| the expression of p53 protein and infection of human papilloma virus in conjunctival and eyelid neoplasms. | human papilloma virus (hpv) infection and loss of p53 function have been identified as frequent events in various human tumors. the aim of this study was to evaluate p53 protein expression and to detect hpv in the tissue samples of 45 benign (papillomas) and 38 malignant conjunctival and eyelid lesions (27 basal cell carcinomas and 11 squamous cell carcinomas). we also looked for eventual relationships between p53 expression and clinicopathological features such as age, histological type of tumo ... | 2005 | 16142387 |
| papillomavirus infection in the conjunctiva of individuals with and without aids: an autopsy series from uganda. | hiv and genus beta human papillomavirus (hpv) types have been associated with squamous cell carcinoma of the conjunctiva (scc). to determine whether conjunctival hpv infection is associated with aids, we analysed 136 lesion-free eye biopsies and tested for genera alpha, beta and gamma hpv types. only infections with genera beta and gamma hpv types was found. after adjustment for age and gender, no excess of genera beta or gamma hpv infection was found in individuals who had died of or with aids ... | 2006 | 16143449 |
| simultaneous human papillomavirus 6 (hpv 6) -positive condyloma acuminatum, hpv 31-positive bowen's disease, and non hpv-associated extramammary paget's disease coexisting within an area presenting clinically as condyloma acuminatum. | an 83-year-old japanese man presented with multiple verrucous papules clustering on a plaque located on the frontal aspect of the scrotum. histologically, there were three distinct epithelial changes compatible with condyloma acuminatum, bowen's disease, and extramammary paget's disease (empd). by in situ hybridization, the zone of condyloma acuminatum was positive for hpv 6 and well demarcated from hpv 31-positive bowen's disease. empd was negative for targeted hpv 6/11/16/18/31/33 probes. immu ... | 2005 | 16148417 |
| pityrosporum and seborrheic keratosis: an association. | seborrheic keratoses (sk) are one of the most common benign tumors of the skin. studies have suggested that human papillomavirus or a benign clonal proliferation of epidermal cells is involved in the pathogenesis of some sk's, however, this issue remains to be resolved. pityrosporum ovale has been implicated in the pathogenesis of seborrheic dermatitis, however, its potential role in association with sk's has not been evaluated as evidenced by the fact that there are no publications in the engli ... | 2005 | 16150211 |
| screening for cervical cancer in the developing world. | cervical cancer remains the most common malignancy amongst females in countries of low income, mainly due to a lack of screening. responsible factors are centred around inadequacies of the pap smear: high cost; low sensitivity; the need of a laboratory with high human expertise; and a demanding logistic system for mass screening. no alternative screening method seems to be clearly advantageous. although combinations of tests have higher sensitivities, they are complex, costly and associated with ... | 2005 | 16150391 |
| knowledge of cervical dysplasia and human papillomavirus among women seen in a colposcopy clinic. | this study was undertaken to evaluate knowledge of cervical dysplasia and human papillomavirus (hpv) among women seen in a colposcopy clinic. | 2005 | 16150483 |
| [detection of telomerase activity in cervical lesions by non-radioactive telomeric repeat amplification protocol (trap)]. | worldwide, the cervical cancer is recognized as the second most common type or malignancy in women. the implementation of the papanicolaou smear has contributed notably to diminish its morbi-mortality. however, this test has a sensibility of just 80%. the detection of telomerase activity (ta) has been proposed as a diagnostic and prognostic maker of a wide variety of tumors and their precursor lesions. in this study the detection of ta was made from samples of cervical exfoliates and its associa ... | 2005 | 16152781 |
| association of human papillomavirus infection with palmoplantar epidermal cysts in korean patients. | human papillomavirus (hpv) infection can develop into many different kinds of diseases ranging from simple warts to carcinoma in situ. some investigators have recently suggested that hpv infection could be closely related to palmoplantar epidermal cysts. the aim of this study was to determine the existence of hpv and its subtype in palmoplantar epidermal cysts of korean patients. we investigated 13 cases of palmoplantar epidermal cysts by employing clinical, histopathological and immunohistochem ... | 2005 | 16159731 |
| synchronous cin 3 and cervical lymphoma: a case report and review of the literature. | primary cervical lymphoma is rare, with less than 60 cases reported in the english literature, including a few cases of synchronous cervical intraepithelial neoplasia (cin) with cervical lymphoma. we describe a 42-year-old woman with cin 3 and malignant lymphoma of the cervix. the papanicolaou cytology only revealed dysplastic cells of cin 3, but not the malignant lymphoid cells. the histology of the cervix revealed diffuse infiltration of monotonous medium-sized lymphoid cells with dispersing t ... | 2005 | 16164048 |
| two distinct activities contribute to human papillomavirus 16 e6's oncogenic potential. | high-risk human papillomaviruses, such as hpv16, cause cervical cancers, other anogenital cancers, and a subset of head and neck cancers. e6 and e7, two viral oncogenes expressed in these cancers, encode multifunctional proteins best known for their ability to bind and inactivate the tumor suppressors p53 and prb, respectively. in skin carcinogenesis experiments using e6 transgenic (k14e6(wt)) mice, hpv16 e6 was found to contribute to two distinct stages in skin carcinogenesis: promotion, a step ... | 2005 | 16166303 |
| characterization of the global profile of genes expressed in cervical epithelium by serial analysis of gene expression (sage). | serial analysis of gene expression (sage) is a new technique that allows a detailed and profound quantitative and qualitative knowledge of gene expression profile, without previous knowledge of sequence of analyzed genes. we carried out a modification of sage methodology (microsage), useful for the analysis of limited quantities of tissue samples, on normal human cervical tissue obtained from a donor without histopathological lesions. cervical epithelium is constituted mainly by cervical keratin ... | 2005 | 16171524 |
| incidence trends of adenocarcinoma of the cervix in 13 european countries. | rapid increases in cervical adenocarcinoma incidence have been observed in western countries in recent decades. postulated explanations include an increasing specificity of subtype-the capability to diagnose the disease, an inability of cytologic screening to reduce adenocarcinoma, and heterogeneity in cofactors related to persistent human papillomavirus infection. this study examines the possible contribution of these factors in relation with trends observed in europe. age-period-cohort models ... | 2005 | 16172231 |
| human papillomavirus infection: biology, epidemiology, and prevention. | over the past several decades, knowledge of the biology and epidemiology of human papillomavirus (hpv) infection has increased tremendously. however, there are still many unanswered questions concerning the interaction of the virus with its host. the virus has been identified as a necessary causal agent for cervical squamous neoplasia and has been linked to the development of neoplasia in several other mucosal sites. the viral oncogenes e6 and e7 are the major players in the virus' scheme to eva ... | 2005 | 16174218 |
| pseudoinfiltrative tubal metaplasia of the endocervix: a potential form of in utero diethylstilbestrol exposure-related adenosis simulating minimal deviation adenocarcinoma. | we report three cases of unusual tubal-type endocervical glandular proliferations simulating minimal deviation adenocarcinoma in women with a history of in utero diethylstilbestrol (des) exposure. the lesions were characterized by haphazard glandular proliferations extending from 3.4 to 6.1 mm into the endocervical stroma and to the margins of excision in all cases. most of the glands were small to medium-sized and round; some exhibited a moderate degree of cystic dilatation, and occasional glan ... | 2005 | 16175088 |
| human papillomavirus 16 minor capsid protein l2 helps capsomeres assemble independently of intercapsomeric disulfide bonding. | the human papillomavirus (hpv) capsomeres (pentamers of major capsid protein l1), which constitute along with l2 the virion capsid, can assemble themselves alone into the l1-capsid particles in vivo and in vitro, depending on intercapsomeric disulfide bonds. to study a possible role of l2 in capsid assembly, we examined the interaction between hpv16 l2 and capsomeres under the conditions that inhibit the formation of disulfide bonds in vitro and in vivo. the purified l2 bound to free capsomeres ... | 2005 | 16175337 |
| correlation between deoxyribonucleic acid loads of human papillomavirus and recurrence of condylomata acuminata. | to determine the correlation between deoxyribonucleic acid (dna) loads of human papillomavirus (hpv) and recurrence of condylomata acuminata (ca), 31 cases of primary ca and 32 cases of recurrent ca were assayed for the hpv6/11 and hpv16/18 dna loads by real-time fluorogenic quantitative pcr. the results showed 62 of the 63 cases were hpv6/11 dna positive (98.4%). the ranges of hpv6/11 dna contained in primary and recurrent ca were 1.4 x 10(3)-6.7 x 10(7) and 1.2 x 10(4)-3.6 x 10(8) copies/ml, r ... | 2005 | 16176626 |
| [inverted naso-sinusal papilloma: analytic study on 13 cases]. | inverted nasosinusal papilloma is a rare tumorous process involving mucosa of nasal fossa and paranasal sinus unilaterally. the authors studied inverted naso-sinusal papilloma observed and treated in ent and head and neck department at brazzaville university hospital. | 2005 | 16180352 |
| associations of high-risk hpv types and viral load with cervical cancer in china. | cervical cancer is the second most common cancer in women worldwide. infection with some genotypes of human papillomavirus is the most important risk factor associated with cervical cancer. | 2006 | 16183329 |
| human leukocyte antigen class i and ii haplotypes and risk of cervical cancer. | human leukocyte antigen (hla) variations may affect immune response to human papillomavirus infection and subsequent cervical neoplasia risk. we investigated the frequency and relationship between hla-a-b and hla-a-b-dr haplotypes among women with cervical cancer/high-grade lesions (n=365) and cytologically normal population controls (n=681) within three cervical neoplasia studies in the us and costa rica. notable differences in haplotype frequencies were observed; the hla-a*01-b*08 haplotype oc ... | 2005 | 16185329 |
| prevalence of human papillomavirus cervical infection in an italian asymptomatic population. | in the last decade many studies have definitely shown that human papillomaviruses (hpvs) are the major cause of cervical carcinogenesis and, in the last few years, hpv testing has been proposed as a new and more powerful tool for cervical cancer screening. this issue is now receiving considerable attention in scientific and non scientific press and hpv testing could be considered the most important change in this field since the introduction of cervical cytology. this paper reports our prevalenc ... | 2005 | 16188026 |
| verrucous carcinoma of the scalp associated with human papillomavirus type 33. | verrucous carcinoma (vc) is a low-grade, well-differentiated squamous cell carcinoma of the skin or mucosae, and human papillomavirus (hpv) infection has been considered to be one of the causative factors of vc at three main sites, including the oral cavity, the genitoanal region, and the foot. however, the relationship between cutaneous vc at other sites and hpv infection remains obscure. | 2005 | 16188198 |
| routine cervical screening with primary hpv testing and cytology triage protocol in a randomised setting. | the role of high-risk human papillomavirus (hrhpv) testing in primary cervical screening has not been established. we generated a randomised evaluation design ultimately to clarify whether primary hrhpv testing implemented into routine screening can bring increase in the programme effectiveness. the aim of the present report on first-year results was to assess the cross-sectional relative validity parameters for routine hrhpv screening, in comparison with conventional screening. an equal number ... | 2005 | 16189520 |
| human papillomavirus type 26-associated periungual squamous cell carcinoma in situ in a hiv-infected patient with concomitant penile and anal intraepithelial neoplasia. | 2005 | 16198810 | |
| characterization of hpv-16 e6 dna vaccines employing intracellular targeting and intercellular spreading strategies. | human papillomavirus (hpv) e6 and e7 are consistently expressed and are responsible for the malignant transformation of hpv-associated lesions. thus, e6 and e7 represent ideal targets for therapeutic hpv vaccine development. we have previously used the gene gun approach to test several intracellular targeting and intercellular spreading strategies targeting hpv-16 e7. these strategies include the use of the sorting signal of lysosome-associated membrane protein (lamp-1), mycobacterium tuberculos ... | 2005 | 16200349 |
| reproducibility of hpv dna testing by hybrid capture 2 in a screening setting. | within a large italian randomized trial on new technologies for cervical cancer screening involving 7 laboratories with different levels of experience, an intralaboratory and interlaboratory quality control program for human papillomavirus (hpv) dna testing by hybrid capture 2 (hc2; digene, gaithersburg, md) was implemented. to monitor the hybridization and detection steps, target samples containing purified, concentration-defined, hpv dna were introduced in each test run. only 3 of 1,024 showed ... | 2005 | 16203283 |
| human papillomavirus infections of the genital and respiratory tracts in young children. | human papillomavirus (hpv) causes papillomas (warts) on the skin and respiratory mucosal surfaces (laryngeal and oral papillomas) in addition to condyloma acuminata (anogenital warts). hpv has become one of the most common sexually transmitted diseases in adults. vertical transmission from mother to infant during birth is well recognized. laryngeal papillomas are the most common tumors of the larynx in children worldwide, and recurrent lesions are common occurrences. anogenital warts in children ... | 2005 | 16210110 |
| identification of human papillomavirus 16-e6 protein-derived peptides with the potential to generate cytotoxic t-lymphocytes toward human leukocyte antigen-a24+ cervical cancer. | human papillomavirus 16 (hpv16)-e6 and -e7 proteins are considered to be appropriate targets in specific immunotherapy for cervical cancer. in this study, we attempted to identify epitope peptides from the hpv16-e6 protein that have the potential to generate cytotoxic t-lymphocytes (ctls) toward human leukocyte antigen (hla)-a24+ cervical cancer. two hpv16-e6 peptides at positions 75-83 and 91-100 effectively induced peptide-specific ctls from peripheral blood mononuclear cells of hla-a24+ cervi ... | 2005 | 16211234 |
| prognostic value of human papillomavirus in the survival of head and neck cancer patients: an overview of the evidence. | despite improvements over the last decade, survival rates for head and neck squamous cell carcinoma (hnscc) remain around 50% and variable. recently, a subset of hnscc has been shown to contain human papillomavirus (hpv) and the presence of hpv in tumors constitutes a prognostic marker of disease. hpv-dna in these tumors (overwhelmingly genotype 16, a high-risk type also found in cervical cancer) is present at high copy numbers, frequently integrated, and often transcriptionally active. in compa ... | 2005 | 16211291 |
| a bi-functional sirna construct induces rna interference and also primes pcr amplification for its own quantification. | rna interference (rnai) is a process of post-transcriptional gene silencing initiated by double-stranded rnas, including short interfering rna (sirna). silencing is sequence-specific and rnai has rapidly become central to the study of gene function. rnai also carries promise for selective silencing of viral and endogenous genes causal for disease. to detect the very low levels of sirna effective for rnai we modified the 3' end of the sense strand of sirna with a nuclease-resistant dna hairpin. w ... | 2005 | 16214804 |
| esophageal squamous papillomatosis. | esophageal squamous papillomatosis is rare and has been associated with gastroesophageal reflux and recurrent respiratory papillomatosis. we report a case of extensive esophageal papillomatosis, no airway involvement and a slowly progressive clinical course with progressive strictures and ultimately fatal squamous cell carcinoma. in-situ hybridization performed on biopsy specimens was negative for high-risk human papilloma virus types. due to the paucity of reported cases, little is conclusively ... | 2005 | 16215437 |
| structural and energetic origins of sequence-specific dna bending: monte carlo simulations of papillomavirus e2-dna binding sites. | dna bending is an important structural feature for indirect readout in protein-dna recognition. the binding of papillomavirus e2 transcription factors to their dna binding sites is associated with dna bending, providing an attractive model system to study the origins of sequence-specific dna bending. the consensus e2 target is of the general form accgn(4)cggt with a variable four base pair region. we applied a new all-atom monte carlo (mc) algorithm that combines effective sampling with fast con ... | 2005 | 16216581 |
| primary prevention of human papillomavirus-dependent neoplasia: no condom, no sex. | cervix cancer is one of several neoplastic disorders that arise following transfer of human papillomavirus (hpv) during unprotected sexual intercourse, and like most other sexually transmitted diseases (stds), is largely preventable by consistent condom use. this primary prevention strategy has received little support, however, when compared with massive secondary prevention initiatives involving cervical screening. the reasons for this anomalous situation are complex, and include: (i) the asymp ... | 2005 | 16223580 |
| sexually-transmitted viral diseases in women: clinical and epidemiological aspects and advances in laboratory diagnosis. | sexually transmitted diseases (stds) have long been known, but they have only recently been recognized as causes of significant long-term morbidity, mainly as a result of increased knowledge concerning viral stds. the relationship of these diseases with conditions such as anogenital cancer and acquired immunodeficiency syndrome (aids) has made viral stds an important issue in the healthcare of women and infants, and in reproductive health. the evolution of the aids pandemic is now characterized ... | 2005 | 16224631 |
| length of human immunodeficiency virus disease and not immune status is a risk factor for development of anal carcinoma. | the anal epithelium is subject to dysplastic change in patients with human immunodeficiency virus (hiv). we sought to determine if the duration of hiv disease or the patient's immune status were associated with the development of anal carcinoma. | 2005 | 16226949 |
| coming to terms with vietnam: the viet/american cervical cancer prevention project. | the viet/american cervical cancer prevention project embraces a dual mission. we seek to develop sustainable, cost-effective cervical cancer prevention services for women in vietnam. because the problem of cervical cancer in vietnam is in part a legacy of the second indochinese war, we also seek to examine obstacles to reconciliation by presenting what most acknowledge to be a remedy in advance of what some will perceive to be an accusation. certain research and commercial interests have produce ... | 2005 | 16240403 |
| prophylactic, therapeutic and anti-metastatic effects of an hpv-16me6delta/me7/tbhsp70delta fusion protein vaccine in an animal model. | human papillomaviruses (hpvs), particularly hpv-16, are not only causally linked to cervical cancers but also play an important role in the development of other cancers. the oncoproteins, e6 and e7, are consistently coexpressed in the majority of hpv-containing carcinomas and their metastatic lesions, and are critical to the induction and maintenance of malignant phenotype, and also can cause tumor metastasis. therefore, e6 and e7 represent ideal tumor-specific antigens for the development of im ... | 2006 | 16242781 |
| type-specific distribution of human papillomavirus in relation to grades of cervical neoplasia. | 2006 | 16246343 | |
| hpv16 e2 gene disruption and polymorphisms of e2 and lcr: some significant associations with cervical cancer in indian women. | we evaluated the status of the hpv16 e2 gene (disrupted or intact), nucleotide sequence alterations within intact e2 genes and lcr of hpv16 isolates in a group of cacx cases (invasive squamous cell carcinomas, n = 81) and population controls (normal cervical scrapes, n = 27) from indian women. | 2006 | 16246404 |
| differential regulation of different human papilloma virus variants by the pou family transcription factor brn-3a. | the brn-3a pou family transcription factor is overexpressed in human cervical carcinoma biopsies and is able to activate expression of the human papilloma virus type 16 (hpv-16) upstream regulatory region (urr), which drives the expression of the e6 and e7 oncoproteins. inhibition of brn-3a expression in human cervical cancer cells inhibits hpv gene expression and reduces cellular growth and anchorage independence in vitro as well as the ability to form tumours in vivo. here, we show that brn-3a ... | 2006 | 16247485 |
| hpv16/18 e7-pulsed dendritic cell vaccination in cervical cancer patients with recurrent disease refractory to standard treatment modalities. | to evaluate the potential of human papillomavirus (hpv) type 16 and 18 e7 antigen-loaded autologous dendritic cells (dc) as a therapeutic cellular vaccine in a case series of cervical cancer patients harboring recurrent/metastatic disease refractory to standard treatment modalities. | 2006 | 16249018 |
| sexually transmitted disease/hiv risk behaviour among women who have sex with women. | to analyse the epidemiological aspects of sexually transmitted diseases (std) among women who have sex with women (wsw) in são paulo, brazil. | 2005 | 16249657 |
| rnai as an antiviral therapy. | there are a dozen or so viruses that will continue to be a serious global health threat for many years to come, mainly due to their chronic nature. these include hepatitis c virus (hcv), human papillomavirus viruses (hpvs), west nile virus and human herpes viruses (i.e., hsv, cmv, ebv, hhv-8, etc.). however, hiv-1 infections will remain at the top of the list due to its high prevalence and the significant mortality and morbidity from aids. the development of a suitable vaccine against hiv-1 rema ... | 2005 | 16255650 |
| the human papillomavirus type 11 e1--e4 protein is a transglutaminase 3 substrate and induces abnormalities of the cornified cell envelope. | the human papillomavirus (hpv) e1--e4 protein is detected in the cytoplasm of differentiated keratinocytes, near the cornified cell envelope. hpv does not induce lysis of the infected keratinocyte, and the normally durable cornified cell envelope that forms during keratinocyte differentiation would seemingly inhibit viral egress. hpv infection induces abnormalities of the cornified cell envelope, but the exact mechanisms involved are not well understood. we tested whether the hpv 11 e1--e4 prote ... | 2006 | 16257432 |
| effects of human papillomavirus type 16 e7 protein on the growth of cervical carcinoma cells and immuno-escape through the tgf-beta1 signaling pathway. | e7 is regarded as one of the main oncoproteins of high-risk human papillomaviruses (hpvs). it may affect the transforming growth factor beta 1 (tgf-beta1) signaling pathway. in this study, the relationship between hpv-16 infection and the functions of three critical factors of the tgf-beta1/smads pathway was explored to assess the possible role of e7 in the development of cervical cancer. | 2006 | 16269171 |
| immortalization of human extravillous cytotrophoblasts by human papilloma virus gene e6e7: sequential cytogenetic and molecular genetic characterization. | extravillous cytotrophoblast (evct) cultures from the normal placentas of three pregnant women were transfected by hpve6e7. sequential cytogenetic and molecular analyses were performed to delineate genetic events that may be critical for cell immortalization. one line, pe1-e6e7, was immortalized successfully, whereas 2 other lines, pe3-e6e7 and pe4-e6e7, could not be maintained beyond crisis. before crisis, the majority of cells in all lines were karyotypically normal. during the early stages of ... | 2005 | 16271953 |
| two different global gene expression profiles in cancer cell lines established from etiologically different oral carcinomas. | cdna arrays were used to characterize the gene expression profiles in 6 oral carcinoma cell lines (ut-scc-10, ut-scc-14, ut-scc-37, ut-scc-54a and ut-scc-54b, ut-scc-74) established from 5 patients with different etiological backgrounds, including young patients, classical risk factors and lichen-derived lesions. in addition, 2 human papillomavirus (hpv)-positive cell lines (hypophraryngeal cancer and hpv16 e6/e7-transformed oral keratinocytes) were similarly tested. two distinct global gene exp ... | 2005 | 16273247 |
| analysis of tumor progression by transcriptional profiling of mouse mk16 cell lines transformed with human papillomavirus type 16 e6 and e7 oncogenes and activated h-ras. | a better understanding of the molecular basis of tumor progression and invasion is needed to improve therapy for malignant tumors. recently, we established a mouse metastatic mk16 model by transduction of secondary kidney cells with human papillomavirus type 16 (hpv16) e6 and e7 oncogenes and human h-ras activated by g12v mutation. in this study, we extended the model to mk16 cell lines derived from lung metastases and compared the oncogenicity of seven cell lines successively isolated from prim ... | 2005 | 16273273 |
| sporadic case of warts, hypogammaglobulinemia, immunodeficiency, and myelokathexis syndrome. | the term whim syndrome (whims) is an acronym describing a rare primary immunodeficiency disorder characterized by warts, hypogammaglobulinemia, immunodeficiency, and myelokathexis, the unusual association of neutropenia with bone marrow myeloid hypercellularity. whims was recently associated with mutations in the gene encoding the chemokine receptor cxcr4 and as such is the first disease ascribed to abnormalities of chemokine signaling. we report a sporadic case of whims in a woman presenting wi ... | 2005 | 16275383 |
| a population-based analysis of temporal trends in the incidence of squamous anal canal cancer in relation to the hiv epidemic. | squamous cell carcinoma of the anal canal (scca) is etiologically linked to human papillomavirus, and its incidence is increased among the immunosuppressed. we used data from the surveillance, epidemiology, and end results program to analyze the incidence of scca in relation to 3 separate periods during the hiv epidemic: the pre-hiv era (1973-1981), the hiv era (1982-1995), and the highly active antiretroviral treatment (haart) era (1996-2001). the incidence per 100,000 population of scca increa ... | 2005 | 16280701 |
| interactions with pocket proteins contribute to the role of human papillomavirus type 16 e7 in the papillomavirus life cycle. | human papillomaviruses (hpvs), most commonly the hpv16 genotype, are the principle etiological determinant for cervical cancer, a common cancer worldwide resulting in over 200,000 deaths annually. the oncogenic properties of hpvs are attributable in part to the virally encoded protein e7, best known for its ability to bind to and induce the degradation of the retinoblastoma tumor suppressor, prb, and related "pocket proteins" p107 and p130. previously, we defined a role for e7 in the productive ... | 2005 | 16282477 |
| skin hyperproliferation and susceptibility to chemical carcinogenesis in transgenic mice expressing e6 and e7 of human papillomavirus type 38. | the oncoproteins e6 and e7 of human papillomavirus type 38 (hpv38) display several transforming activities in vitro, including immortalization of primary human keratinocytes. to evaluate the oncogenic activities of the viral proteins in an in vivo model, we generated transgenic mice expressing hpv38 e6 and e7 under the control of the bovine homologue of the human keratin 10 (k10) promoter. two distinct lines of hpv38 e6/e7-expressing transgenic mice that express the viral genes at different leve ... | 2005 | 16282489 |
| awareness of general and personal risk factors for uterine cancer among healthy women. | participation rates in gynaecological cancer screening are influenced by different factors. the knowledge of general and personal risk factors for uterine cancer among women might influence their interest in gynaecological cancer screening. two thousand nine hundred women in 23 gynaecological outpatient services were invited to answer a structured questionnaire regarding general and personal risk factors for cervical and endometrial carcinoma; 2108 women participated. women with a history of can ... | 2005 | 16284496 |