Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| comment on: emergence and molecular characterization of haemophilus influenzae harbouring mef(a). | 2017 | 28407074 | |
| active offer of vaccinations during hospitalization improves coverage among splenectomized patients: an italian experience. | in 2014, an italian hospital implemented a protocol for pneumococcal, meningococcal, and haemophilus influenzae type b vaccines offer to splenectomized patients during their hospitalization. after 1 year, coverage for recommended vaccinations increased from 5.7%-66.7% and the average time between splenectomy and vaccines administration decreased from 84.7-7.5 days. | 2017 | 28410825 |
| bacterial and histopathological findings in deep head and neck infections: a retrospective analysis. | deep neck infections are among the most dangerous acute diseases in the head and neck region. this analysis gives an overview of the bacterial and histopathologic findings of deep neck infections. | 2017 | 28411005 |
| nasopharyngeal polymicrobial colonization during health, viral upper respiratory infection and upper respiratory bacterial infection. | we sought to understand how polymicrobial colonization varies during health, viral upper respiratory infection (uri) and acute upper respiratory bacterial infection to understand differences in infection-prone vs. non-prone patients. | 2017 | 28412081 |
| performance evaluation of a newly developed and fully automated bacteriological analyzer "raisus any" for antimicrobial susceptibility testing of fastidious bacteria haemophilus influenzae and streptococcus pneumoniae. | antimicrobial susceptibility testing for fastidious bacteria, such as haemophilus influenzae (h. influenzae) and streptococcus pneumoniae (s. pneumoniae) has been performed manually. we evaluated the performance of a newly developed fully automated system for rapid bacterial identification and antimicrobial susceptibility testing "raisus any" (nissui pharmaceutical co., ltd.). | 2017 | 28413870 |
| typing and characterization of bacteria using bottom-up tandem mass spectrometry proteomics. | methods for rapid and reliable microbial identification are essential in modern healthcare. the ability to detect and correctly identify pathogenic species and their resistance phenotype is necessary for accurate diagnosis and efficient treatment of infectious diseases. bottom-up tandem mass spectrometry (ms) proteomics enables rapid characterization of large parts of the expressed genes of microorganisms. however, the generated data are highly fragmented, making downstream analyses complex. her ... | 2017 | 28420677 |
| immunization with 10-valent pneumococcal non-typeable haemophilus influenzae protein d conjugate vaccine (phid-cv) according to different schedules in infants in south africa: a phase iii trial. | limited clinical data exists to assess differences between various infant pneumococcal conjugate vaccine schedules. in this trial, we evaluated immunogenicity of the 10-valent pneumococcal non-typeable haemophilus influenzae protein d conjugate vaccine (phid-cv) administered using 3 different immunization schedules in hiv unexposed-uninfected infants in south africa. | 2017 | 28425818 |
| factors affecting sound energy absorbance in acute otitis media model of chinchilla. | acute otitis media (aom) is a rapid-onset infection of the middle ear which results in middle ear pressure (mep), middle ear effusion (mee), and structural changes in middle ear tissues. previous studies from our laboratory have identified that mep, mee, and middle ear structural changes are three factors affecting tympanic membrane (tm) mobility and hearing levels (guan et al., 2014, 2013). sound energy reflectance or absorbance (ea) is a diagnostic tool increasingly used in clinical settings f ... | 2017 | 28426992 |
| invasive haemophilus influenzae infections in children in kamikawa subprefecture, hokkaido, japan, 2006-2015: the effectiveness of h. influenzae type b vaccine. | we evaluated 24 children with invasive haemophilus influenzae infections between 2006 and 2015 in kamikawa subprefecture of hokkaido, japan. the most frequent disease was pneumonia in 12 cases (50.0%), followed by meningitis in 7 (29.2%) and bacteremia in 5 (20.8%). patients ranged in age from 3 months to 12 years of age. seventeen (70.8%) of the total were less than 2 years old. the incidence rate of h. influenzae infection varied from 15.1 to 36.3 per 100,000 population in the kamikawa area du ... | 2017 | 28427992 |
| antimicrobial susceptibility of bacterial isolates from patients presenting with ear, nose and throat (ent) infections in the german community healthcare setting. | empiric initial antibiotic therapy of bacterial infections is based primarily upon the susceptibility of the most common causative pathogens. the purpose of this study was to provide susceptibility data on six bacterial species known to cause ear, nose and throat (ent) infections. a total of 1066 isolates collected during a nationwide laboratory-based surveillance study were analysed. all streptococcus pyogenes isolates were penicillin (pen)-susceptible, indicating that natural penicillins can s ... | 2017 | 28429163 |
| childhood vaccinations and risk of acute lymphoblastic leukaemia in children. | it has been proposed that childhood vaccinations protect against acute lymphoblastic leukaemia (all) in children by modulation of future responses to common infections in childhood. however, the available studies provide inconsistent findings, and population-based cohort studies with longitudinal information on vaccinations are lacking. | 2017 | 28431124 |
| etiological analysis and epidemiological comparison among adult cap and nhcap patients in okinawa, japan. | etiological epidemiology and diagnosis are important issues for cap and nhcap. despite the availability of effective therapies, significant morbidity and mortality ensues. | 2017 | 28431934 |
| a prospective, observational cohort study of the seasonal dynamics of airway pathogens in the aetiology of exacerbations in copd. | the aetiology of acute exacerbations of copd (aecopd) is incompletely understood. understanding the relationship between chronic bacterial airway infection and viral exposure may explain the incidence and seasonality of these events. | 2017 | 28432209 |
| antibiogram profile of septic meningitis among children in duhok, iraq. | to determine the prevalence of bacteria in the cerebrospinal fluid (csf), and the antibiogram profile in pediatric patients with suspected meningitis. methods: this descriptive study was conducted between january 2014 and january 2016 in the hevi paediatric teaching hospital in duhok, iraq. the csf samples were withdrawn from 432 pediatric patients suspected of meningitis. the samples were cultured, and antibiotic sensitivity tests were performed. results: there were 33 (7.6%) culture positive ... | 2017 | 28439602 |
| correction: relationships between mucosal antibodies, non-typeable haemophilus influenzae (nthi) infection and airway inflammation in copd. | [this corrects the article doi: 10.1371/journal.pone.0167250.]. | 2017 | 28441440 |
| effects of n-acetyl-l-cysteine on the membrane vesicle release and growth of respiratory pathogens. | bacterial infections contribute to the disease progression of chronic obstructive pulmonary disease by stimulating mucus production in the airways. this increased mucus production and other symptoms are often alleviated when patients are treated with mucolytics such as n-acetyl-l-cysteine (nac). moreover, nac has been suggested to inhibit bacterial growth. bacteria can release membrane vesicles (mvs) in response to stress, and recent studies report a role for these proinflammatory mvs in the pat ... | 2017 | 28444395 |
| insights on persistent airway infection by non-typeable haemophilus influenzae in chronic obstructive pulmonary disease. | non-typeable haemophilus influenzae (nthi) is the most common bacterial cause of infection of the lower airways in adults with chronic obstructive pulmonary disease (copd). infection of the copd airways causes acute exacerbations, resulting in substantial morbidity and mortality. nthi has evolved multiple mechanisms to establish infection in the hostile environment of the copd airways, allowing the pathogen to persist in the airways for months to years. persistent infection of the copd airways c ... | 2017 | 28449098 |
| effect of prophylactic or therapeutic administration of paracetamol on immune response to dtwp-hepb-hib combination vaccine in indian infants. | vaccination is considered as the most cost effective method for preventing infectious diseases. low grade fever is a known adverse effect of vaccination. in india, it is a common clinical practice to prescribe paracetamol either prophylactically or therapeutically to manage fever. some studies have shown that paracetamol interferes with antibody responses following immunization. this manuscript reports the outcome of a post hoc analysis of data from a clinical trial of a pentavalent vaccine in i ... | 2017 | 28449972 |
| complete genome sequence of bordetella pertussis pelita iii, the production strain for an indonesian whole-cell pertussis vaccine. | pt bio farma, the sole world health organization-approved indonesian vaccine producer, manufactures a whole-cell whooping cough vaccine (wp) that, as part of a pentavalent diphtheria-tetanus-pertussis/hepatitis b/haemophilus influenzae b (dtp/hb/hib) vaccine, is used in indonesia and many other countries. we report here the whole-genome sequence for bordetella pertussis pelita iii, pt bio farma's wp production strain. | 2017 | 28450511 |
| role of neural barriers in the pathogenesis and outcome of streptococcus pneumoniae meningitis. | bacterial meningitis is an inflammatory disease of the meninges of the central nervous system (cns). streptococcus pneumoniae (s. pneumoniae), neisseria meningitidis, and haemophilus influenzae are the major bacterial pathogens causing meningitis with s. pneumoniae being responsible for two thirds of meningitis cases in the developed world. to reach the cns following nasopharyngeal colonization and bacteraemia, the bacteria traverse from the circulation across the blood brain barrier (bbb) and c ... | 2017 | 28450902 |
| pediatric bacterial meningitis in japan, 2013-2015 - 3-5 years after the wide use of haemophilus influenzae type b and streptococcus pneumoniae conjugated vaccines. | haemophilus influenzae type b (hib) vaccine and pneumococcal conjugated vaccine (pcv) have been widely used since 2010 in japan when both vaccines were supported by the regional governments, and they were covered as routine recommended vaccines in 2013. the incidence of bacterial meningitis due to these organisms decreased in 2011 and 2012, but meningitis due to streptococcus agalactiae and escherichia coli remained unchanged. | 2017 | 28456490 |
| utilizing pharmacy intervention in asplenic patients to improve vaccination rates. | asplenic patients are at increased risk for post-splenectomy infection caused by streptococcus pneumoniae, neisseria meningitidis, and haemophilus influenzae type b (hib), and vaccination rates against these organisms remain low. the purpose of this study was to evaluate vaccination rates before and after implementation of a pharmacist-driven electronic vaccination tracking system. | 2017 | 28464987 |
| recurrent otorrhea in chronic suppurative otitis media: is biofilm the missing link? | dispersal of bacteria from a biofilm in the middle ear, serving as a bacterial reservoir, could explain the recurrent and chronic nature of chronic suppurative otitis media (csom). the objective of this study is to investigate if the same strains of bacteria could be detected in repeated episodes of otorrhea in csom. in a prospective case series at a primary healthcare clinic in nuuk, greenland, patients with more than 14 days of otorrhea were included consecutively. samples for culturing and bi ... | 2017 | 28466356 |
| occult bacteremia: should we look for the needle in the haystack? | once a well-recognized entity, occult bacteremia (ob) is no longer a significant or serious bacterial infection. first following the introduction of the haemophilus influenzae type b vaccine and now with the implementation of the conjugate pneumococcal vaccine (pcv), the number of cases has declined significantly. this has led to a change in many published guidelines to avoid taking blood cultures in fully vaccinated children presenting with fever. in israel, the introduction of the pcv13 is now ... | 2016 | 28466611 |
| effect of the 13-valent pneumococcal conjugate vaccine on nasopharyngeal carriage by respiratory pathogens among greenlandic children. | in 2010, greenland introduced the 13-valent pneumococcal conjugate vaccine (prevnar 13®- pcv-13) in the childhood immunisation program. the authors aimed to evaluate the impact of pcv-13 on nasopharyngeal carriage of bacteria frequently associated with respiratory infections in children. | 2017 | 28467237 |
| epidemiology of nasopharyngeal carriage by haemophilus influenzae in healthy children: a study in the mediterranean coast region. | haemophilus influenzae (hi), a colonizer of the nasopharynx in children causes mainly otitis and sinusitis. the primary objective of this study was to determine the prevalence of pharyngeal colonization by hi, and the secondary objectives were to identify risk factors associated with hi colonization and its antibiotic susceptibility. | 2017 | 28472007 |
| serotype changes and antimicrobial nonsusceptibility rates of invasive and non-invasive streptococcus pneumoniae isolates after implementation of 10-valent pneumococcal nontypeable haemophilus influenzae protein d conjugate vaccine (phid-cv) in bulgaria. | the 10-valent pneumococcal conjugate vaccine (pcv10) has been included in bulgarian childhood immunization program since 2010. this study aimed to assess serotype distribution and antimicrobial resistance of 198 invasive and non-invasive streptococcus pneumoniae strains that had been isolated in bulgaria during 2011-2016 from patients with invasive (ipd) and non-invasive (nipd) pneumococcal diseases. the most common invasive serotypes were 3 (10.1%), 19f (4.0%), and 7f (3.0%). a significant decr ... | 2017 | 28472614 |
| individual preferences for child and adolescent vaccine attributes: a systematic review of the stated preference literature. | discrete choice experiments are increasingly used to assess preferences for vaccines and vaccine service delivery. | 2017 | 28474295 |
| cost-effectiveness analysis of vaccinations and decision makings on vaccination programmes in hong kong: a systematic review. | to describe and systematically review the modelling and reporting of cost-effectiveness analysis of vaccination in hong kong, and to identify areas for quality enhancement in future cost-effectiveness analyses. | 2017 | 28476628 |
| mucosal and systemic immune response to sublingual or intranasal immunization with phosphorylcholine. | phosphorylcholine (pc) is a structural component of a wide variety of pathogens including streptococcus pneumoniae and haemophilus influenzae. here, the immune response in mice to pc immunization via the sublingual (sl) route versus the intranasal (in) route was investigated in terms of efficacy and safety. | 2017 | 28478921 |
| monophosphoryl lipid a enhances nontypeable haemophilus influenzae-specific mucosal and systemic immune responses by intranasal immunization. | acute otitis media (aom) is one of the most common infectious diseases in children. nontypeable haemophilus influenzae (nthi) is gram-negative bacteria that are considered major pathogens of aom and respiratory tract infections. in this study, we used monophosphoryl lipid a (mpl), a toll-like receptor (tlr) 4 agonist, as an adjuvant to induce mucosal immune responses against nthi to enhance bacterial clearance from the nasopharynx. | 2017 | 28483250 |
| infectious complications of pediatric cochlear implants are highly influenced by otitis media. | determine the incidence of ear infections in cochlear implant patients, evaluate the contribution of otitis media to complications, describe the bacteriology of otitis media in the cochlear implant population, the treatment provided at our center, and the long term outcome. | 2017 | 28483256 |
| surveillance of the activity of solithromycin (cem-101) against bacteria from respiratory tract infections. | the activity of solithromycin, a fourth-generation macrolide and novel fluoroketolide, was evaluated by determining its minimum inhibitory concentration (mic) (via clinical and laboratory standards institute broth microdilution) against 2797 contemporary clinical respiratory tract isolates collected from north america, europe, asia-pacific and other regions of the world in 2012-13. solithromycin was very active against streptococcus pneumoniae and streptococcus pyogenes, with mic90 of 0.25 and 0 ... | 2017 | 28483717 |
| investigations of a possible chemical effect of salvadora persica chewing sticks. | salvadora persica is commonly used chewing sticks in many parts of the world as an oral hygiene tool. this study measured the amount of benzyl isothiocyanate (bitc) released into the mouth and assessed its retention time in saliva. the study also tested if the released amount of bitc could potentially be antibacterial or cytotoxic. twelve subjects brushed their teeth with fresh miswak once, twice, and four times. the amount of bitc in the saliva and in the used brushes was quantified using gas c ... | 2017 | 28484501 |
| polysaccharide conjugate vaccine protein carriers as a "neglected valency" - potential and limitations. | the development of vaccines against polysaccharide-encapsulated pathogens (e.g. haemophilus influenzae type b, pneumococci, meningococci) is challenging because polysaccharides do not elicit a strong and long-lasting immune response (i.e. t-cell independent). this can be overcome by conjugating the polysaccharide to a protein carrier (e.g. tetanus toxoid, cross-reacting material 197 [crm]), which vastly improves the immune response and induces memory to the polysaccharide (t-cell dependent). alt ... | 2017 | 28487056 |
| curcumin inhibits nthi-induced muc5ac mucin overproduction in otitis media via upregulation of mapk phosphatase mkp-1. | otitis media (om), characterized by the presence of mucus overproduction and excess inflammation in the middle ear, is the most common childhood infection. nontypeable haemophilus influenzae (nthi) pathogen is responsible for approximately one-third of episodes of bacteria-caused om. current treatments for bacterial om rely on the systemic use of antibiotics, which often leads to the emergence of multidrug resistant bacterial strains. therefore there is an urgent need for developing alternative ... | 2017 | 28487811 |
| bacteria isolated from the airways of paediatric patients with bronchiectasis according to hiv status. | knowledge of which bacteria are found in the airways of paediatric patients with bronchiectasis unrelated to cystic fibrosis (cf) is important in defining empirical antibiotic guidelines for the treatment of acute infective exacerbations. | 2017 | 28492126 |
| development of immunochromatographic colloidal gold test strip for rapid detection of haemophilus influenzae in clinical specimens. | a simple and fast test strip for simultaneous detection of haemophilus influenzae, based on the theory of colloidal gold immunochromatography was developed. | 2017 | 28497596 |
| the asplenic patient: post-insult immunocompetence, infection, and vaccination. | splenic injury can occur through multiple mechanisms and may result in various degrees of residual immunocompetence. functionally or anatomically asplenic patients are at higher risk for infection, particularly with encapsulated bacteria. vaccination is recommended to prevent infection with these organisms; however, the recommendations are routinely updated, and vaccine selection and timing are complex. | 2017 | 28498097 |
| haemophilus influenzae type b meningitis: is there a re-emergence? 24 years of experience in a children's hospital. | haemophilus influenzae type b (hib) used to be the main cause of bacterial meningitis in children younger than 5 years old. following the introduction of the hib vaccine in the immunization schedule (1998), its incidence reduced significantly but it has increased over the last years. the objectives of this study included describing the characteristics and analyzing the epidemic curve of haemophilus influenzae type b (hib) meningitis by comparing the pre- and postimmunization periods. | 2017 | 28504487 |
| multiple drug resistance in haemophilus influenzae isolated from patients in bangkok, thailand. | 2017 | 28506825 | |
| flagellar expression in clinical isolates of non-typeable haemophilus influenzae. | haemophilus influenzae is a commensal organism found in the upper respiratory tract of humans. when h. influenzae becomes a pathogen, these bacteria can move out of their commensal niche and cause multiple respiratory tract diseases such as otitis media, sinusitis, conjunctivitis and bronchitis in children, and chronic obstructive pulmonary disease in adults. however, h. influenzae is currently considered a non-flagellate bacterium. | 2017 | 28513418 |
| epidemiology of paediatric meningitis in central côte d'ivoire after the implementation of haemophilus influenzae type b vaccination. | infectious meningitis accounts for enormous morbidity worldwide, but there is a paucity of data on its regional epidemiology in resource-constrained settings of sub-saharan africa. here, we present a study on the aetiology of paediatric meningitis in central côte d'ivoire. between june 2012 and december 2013, all cerebrospinal fluid (csf) samples drawn at the university teaching hospital bouaké were examined for the presence of bacterial and fungal pathogens. a causative agent was detected in 31 ... | 2017 | 28513815 |
| respiratory viral infections are underdiagnosed in patients with suspected sepsis. | the study aim was to investigate the prevalence and clinical relevance of viral findings by multiplex pcr from the nasopharynx of clinically septic patients during a winter season. during 11 weeks of the influenza epidemic period in january-march 2012, consecutive adult patients suspected to be septic (n = 432) were analyzed with cultures from blood and nasopharynx plus multiplex pcr for respiratory viruses on the nasopharyngeal specimen. the results were compared with those from microbiology an ... | 2017 | 28516200 |
| the sensor study: protocol for a mixed-methods study of self-management checks to predict exacerbations of pseudomonas aeruginosa in patients with long-term respiratory conditions. | there are an estimated three million people in the united kingdom with chronic obstructive pulmonary disease (copd), and the incidence of bronchiectasis is estimated at around 0.1% but is more common in copd and severe asthma. both copd and bronchiectasis are characterized by exacerbations in which bacteria play a central role. pseudomonas aeruginosa is isolated from sputum samples from 4% to 15% of adults with copd and is more likely to be isolated from patients with severe disease. earlier det ... | 2017 | 28526665 |
| budesonide, fluticasone propionate, and azithromycin do not modulate the membrane vesicle release by thp-1 macrophages and respiratory pathogens during macrophage infection. | patients with more severe chronic obstructive pulmonary disease frequently experience exacerbations and it is estimated that up to 50% of these exacerbations are associated with bacterial infections. the mainstay treatment for these infection-related exacerbations constitutes the administration of glucocorticoids, alone or in combination with antibiotics. a recent line of evidence demonstrates that many hormones including the steroid beclomethasone can also directly affect bacterial growth, viru ... | 2017 | 28528362 |
| live attenuated tetravalent (g1-g4) bovine-human reassortant rotavirus vaccine (brv-tv): randomized, controlled phase iii study in indian infants. | rotavirus remains the leading cause of diarrhoea among children <5years. we assessed immunogenic non-inferiority of a tetravalent bovine-human reassortant rotavirus vaccine (brv-tv) over the licensed human-bovine pentavalent rotavirus vaccine rv5. | 2017 | 28536027 |
| lot-to-lot consistency, safety and immunogenicity of 3 lots of haemophilus influenzae type b conjugate vaccine: results from a phase iii randomized, multicenter study in infants. | vaccination against haemophilus influenzae type b (hib) is included in routine pediatric immunization schedule in the united states. previous vaccine shortages have created the need for additional options for hib vaccination. | 2017 | 28536030 |
| bronchial inflammation and bacterial load in stable copd is associated with tlr4 overexpression. | toll-like receptors (tlrs) and nucleotide-binding oligomerisation domain (nod)-like receptors (nlrs) are two major forms of innate immune sensors but their role in the immunopathology of stable chronic obstructive pulmonary disease (copd) is incompletely studied. our objective here was to investigate tlr and nlr signalling pathways in the bronchial mucosa in stable copd.using immunohistochemistry, the expression levels of tlr2, tlr4, tlr9, nod1, nod2, cd14, myeloid differentiation primary respon ... | 2017 | 28536249 |
| nontypeable haemophilus influenzae and chronic obstructive pulmonary disease: a review for clinicians. | chronic obstructive pulmonary disease (copd) is a leading cause of morbidity and mortality worldwide. in the lower airways of copd patients, bacterial infection is a common phenomenon and haemophilus influenzae is the most commonly identified bacteria. haemophilus influenzae is divided into typeable and nontypeable (nthi) strains based on the presence or absence of a polysaccharide capsule. while nthi is a common commensal in the human nasopharynx, it is associated with considerable inflammation ... | 2017 | 28539074 |
| abnormal brain connectivity spectrum disorders following thimerosal administration: a prospective longitudinal case-control assessment of medical records in the vaccine safety datalink. | autism spectrum disorder (asd), tic disorder (td), and hyperkinetic syndrome of childhood (attention deficit disorder [add]/attention deficit hyperactivity disorder [adhd]) are disorders recently defined as abnormal connectivity spectrum disorders (acsds) because they show a similar pattern of abnormal brain connectivity. this study examines whether these disorders are associated with exposure to thimerosal, a mercury (hg)-based preservative. | 2017 | 28539852 |
| the carriage of interleukin-1b-31*c allele plus staphylococcus aureus and haemophilus influenzae increases the risk of recurrent tonsillitis in a mexican population. | the aim of the present study was to estimate the relative contribution of immunogenetic and microbiological factors in the development of recurrent tonsillitis in a mexican population. patients (n = 138) with recurrent tonsillitis and an indication of tonsillectomy (mean age: 6.05 years ± 3.00; median age: 5 years, female: 58; age range: 1-15 years) and 195 non-related controls older than 18 years and a medical history free of recurrent tonsillitis were included. to evaluate the microbial contri ... | 2017 | 28542534 |
| investigation of bronchiectasis in severe uncontrolled asthma. | the presence of bronchiectasis in patients with asthma varies in different reports, while a clear aetiological relation has not been precisely established. | 2017 | 28544140 |
| update on the epidemiology and antibiotic resistance of ocular infections. | the purpose of this review is to provide an update on the epidemiology and current antibiotic-resistant threats in ophthalmology. | 2017 | 28546690 |
| commercial essential oils as potential antimicrobials to treat skin diseases. | essential oils are one of the most notorious natural products used for medical purposes. combined with their popular use in dermatology, their availability, and the development of antimicrobial resistance, commercial essential oils are often an option for therapy. at least 90 essential oils can be identified as being recommended for dermatological use, with at least 1500 combinations. this review explores the fundamental knowledge available on the antimicrobial properties against pathogens respo ... | 2017 | 28546822 |
| bacteriology and antibiotic sensitivity of tonsillar diseases in chinese children. | although many bacteriology studies on tonsillar diseases have been completed, only a few studies investigated bacteriology of tonsillar diseases in recent years, especially in asian children population. the aim of our study is to elucidate the bacterial flora and antibiotic sensitivity of tonsillar diseases in chinese children. a three-center study was performed on 2994 children with or without tonsillar diseases. we compared and analyzed differences of bacterial pathogens among recurrent tonsil ... | 2017 | 28551703 |
| life-threatening pneumopathy and u urealyticum in a stat3-deficient hyper-ige syndrome patient. | a deficiency in signal transducer and activator of transcription 3 (stat3) is responsible for autosomal dominant hyperimmunoglobulin e syndrome, an immunodeficiency syndrome causing staphylococcus aureus, streptococcus pneumonia, haemophilus influenzae, and, rarely, pseudomonas aeruginosa and aspergillus sp infections. currently, intracellular pathogens are not targeted in the management of severe infections. the pathophysiologic mechanism of hyperimmunoglobulin e syndrome immunodeficiency has r ... | 2017 | 28562253 |
| impact of protein d-containing pneumococcal conjugate vaccines on non-typeable haemophilus influenzae acute otitis media and carriage. | protein d-containing vaccines may decrease acute otitis media (aom) burden and nasopharyngeal carriage of non-typeable haemophilus influenzae (nthi). protein d-containing pneumococcal conjugate vaccine phid-cv (synflorix, gsk vaccines) elicits robust immune responses against protein d. however, the phase iii clinical otitis media and pneumonia study (compas), assessing phid-cv efficacy against various pneumococcal diseases, was not powered to demonstrate efficacy against nthi; only trends of pro ... | 2017 | 28571504 |
| colonization density of the upper respiratory tract as a predictor of pneumonia-haemophilus influenzae, moraxella catarrhalis, staphylococcus aureus, and pneumocystis jirovecii. | there is limited information on the association between colonization density of upper respiratory tract colonizers and pathogen-specific pneumonia. we assessed this association for haemophilus influenzae, moraxella catarrhalis, staphylococcus aureus, and pneumocystis jirovecii. | 2017 | 28575367 |
| ampicillin resistance in haemophilus influenzae from copd patients in the uk. | haemophilus influenzae is commonly isolated from the airways of copd patients. antibiotic treatment may cause the emergence of resistant h. influenzae strains, particularly ampicillin-resistant strains, including β-lactamase-negative ampicillin resistance (blnar) strains. genetic identification using ftsi sequencing is the optimum method for identifying mutations within blnar strains. the prevalence of blnar in copd patients during the stable state has not been reported. we investigated the anti ... | 2017 | 28579769 |
| highly specific and rapid glycan based amperometric detection of influenza viruses. | rapid and precise detection of influenza viruses in a point of care setting is critical for applying appropriate countermeasures. current methods such as nucleic acid or antibody based techniques are expensive or suffer from low sensitivity, respectively. we have developed an assay that uses glucose test strips and a handheld potentiostat to detect the influenza virus with high specificity. influenza surface glycoprotein neuraminidase (na), but not bacterial na, cleaved galactose bearing substra ... | 2017 | 28580101 |
| implementation of the new virtuo blood culture system: evaluation and comparison to the 3d system using simulated blood cultures. | to evaluate the performances of the newly approved bact/alert virtuo blood culture system for the recovery of bloodstream pathogens and compare it to the bact/alert 3d system. | 2017 | 28583022 |
| immunogenicity and safety of a new hexavalent vaccine (dtap5-ipv-hb-hib) administered in a mixed primary series schedule with a pentavalent vaccine (dtap5-ipv-hib). | dtap5-ipv-hb-hib vaccine is a fully-liquid, combination hexavalent vaccine. this phase iii, open-label, multicentre study conducted in spain, evaluated the immune response to all dtap5-ipv-hb-hib antigens when the vaccine was used in a mixed hexa/penta/hexa primary series. infants (who had received one dose of hepatitis b vaccine at birth) received a mixed schedule including dtap5-ipv-hb-hib (prp-omp conjugate) at 2 and 6months of age, dtap5-ipv-hib at 4months, meningococcal serogroup c conjugat ... | 2017 | 28583305 |
| bacterial infections after pediatric heart transplantation: epidemiology, risk factors and outcomes. | bacterial infections represent a major cause of morbidity and mortality in heart transplant recipients. however, data describing the epidemiology and outcomes of these infections in children are limited. | 2017 | 28583371 |
| reemergence of the natural history of otolaryngologic infections: lessons learned from 2 american presidents. | presidents george washington and theodore roosevelt suffered complications of epiglottitis and otomastoiditis, respectively. the introduction of antibiotics and vaccinations against haemophilus influenzae and streptococcus pneumoniae has significantly reduced the incidence of these otolaryngologic infections, such that the natural history of the disease is rarely encountered. however, antibiotic resistance and pathogenic evolution has raised concern about increased virulence of these common orga ... | 2017 | 28585510 |
| bacterial meningitis in finland, 1995-2014: a population-based observational study. | bacterial meningitis remains an important cause of morbidity and mortality worldwide. its epidemiological characteristics, however, are changing due to new vaccines and secular trends. conjugate vaccines against haemophilus influenzae type b and streptococcus pneumoniae (10-valent) were introduced in 1986 and 2010 in finland. we assessed the disease burden and long-term trends of five common causes of bacterial meningitis in a population-based observational study. | 2017 | 28592578 |
| seasonality of acquisition of respiratory bacterial pathogens in young children with cystic fibrosis. | seasonal variations are often observed for respiratory tract infections; however, limited information is available regarding seasonal patterns of acquisition of common cystic fibrosis (cf)-related respiratory pathogens. we previously reported differential seasonal acquisition of pseudomonas aeruginosa in young children with cf and no such variation for methicillin-susceptible staphylococcus aureus acquisition. the purpose of this study was to describe and compare the seasonal incidence of acquis ... | 2017 | 28599639 |
| the epidemiology, management, and outcomes of bacterial meningitis in infants. | the pathogens that cause bacterial meningitis in infants and their antimicrobial susceptibilities may have changed in this era of increasing antimicrobial resistance, use of conjugated vaccines, and maternal antibiotic prophylaxis for group b streptococcus (gbs). the objective was to determine the optimal empirical antibiotics for bacterial meningitis in early infancy. | 2017 | 28600447 |
| the moda2 phasevarion of nontypeable haemophilus influenzae regulates resistance to oxidative stress and killing by human neutrophils. | nontypeable haemophilus influenzae (nthi) is the causative agent of multiple respiratory tract infections. several human pathogens, including nthi, possess a novel genetic system, termed the phasevarion, which mediates a rapid and reversible change in the expression of many genes throughout the chromosome. this occurs by phase variation of a single gene (moda) that encodes a dna methyltransferase and results in two phenotypically distinct subpopulations, on and off. nthi encounters many pressure ... | 2017 | 28600561 |
| simultaneous identification of haemophilus influenzae and haemophilus haemolyticus using real-time pcr. | to design a highly specific and sensitive multiplex real-time pcr assay for the differentiation of the pathogen haemophilus influenzae from its nonpathogenic near-neighbor haemophilus haemolyticus. | 2017 | 28604066 |
| streptococcus pneumoniae otitis media pathogenesis and how it informs our understanding of vaccine strategies. | this study aimed to review the literature regarding the mechanisms of transition from asymptomatic colonization to induction of otitis media and how the insight into the pathogenesis of otitis media has the potential to help design future otitis media-directed vaccines. | 2017 | 28616365 |
| single variant bottleneck in the early dynamics of h. influenzae bacteremia in neonatal rats questions the theory of independent action. | there is an abundance of information about the genetic basis, physiological and molecular mechanisms of bacterial pathogenesis. in contrast, relatively little is known about population dynamic processes, by which bacteria colonize hosts and invade tissues and cells and thereby cause disease. in an article published in 1978, moxon and murphy presented evidence that, when inoculated intranasally with a mixture streptomycin sensitive and resistant (sm (s) and sm (r) ) and otherwise isogenic strains ... | 2017 | 28617678 |
| antimicrobial susceptibility of haemophilus influenzae strains isolated from the urethra of men with acute urethritis and/or epididymitis. | we determined minimum inhibitory concentrations (mics) of 41 antimicrobial agents for 73 clinical strains of haemophilusinfluenzae isolated from the urethra of men with acute urethritis and/or epididymitis and examined the strains for the production of β-lactamase. we also compared their antimicrobial susceptibilities with those of h. influenzae strains from respiratory tract or otorhinolaryngological infections that were reported in japan. the proportion of β-lactamase-nonproducing ampicillin-r ... | 2017 | 28619239 |
| identification of a large family of slam-dependent surface lipoproteins in gram-negative bacteria. | the surfaces of many gram-negative bacteria are decorated with soluble proteins anchored to the outer membrane via an acylated n-terminus; these proteins are referred to as surface lipoproteins or slps. in neisseria meningitidis, slps such as transferrin-binding protein b (tbpb) and factor-h binding protein (fhbp) are essential for host colonization and infection because of their essential roles in iron acquisition and immune evasion, respectively. recently, we identified a family of outer membr ... | 2017 | 28620585 |
| haemophilus influenzae vulvovaginitis associated with rhinitis caused by the same clone in a prepubertal girl. | vulvovaginitis caused by upper respiratory flora is generally considered to be the most common gynecological problem in prepubertal girls. to date, however, no direct evidence has been obtained for the underlying mechanism of transmission. this report describes a case of non-capsulate haemophilus influenzae vulvovaginitis in a 6-year-old girl with a history of foreign bodies (cotton wool) in her vagina. moreover, this girl had recurrent rhinitis for approximately 3 years. on pulsed field gel ele ... | 2017 | 28621044 |
| timeliness and completeness of routine childhood vaccinations in children by two years of age in alberta, canada. | assessing timeliness and completeness of vaccine administration is important for evaluating the effectiveness of immunization programs. few studies have reported timeliness, particularly in canada. the objective of this study was to examine timeliness of the receipt of vaccination for each routine childhood recommended vaccine by 24 months of age among children in a community-based pregnancy cohort in calgary, alberta. | 2017 | 28621647 |
| haemophilus influenzae oral vaccination for preventing acute exacerbations of chronic bronchitis and chronic obstructive pulmonary disease. | chronic bronchitis and chronic obstructive pulmonary disease (copd) are serious conditions in which patients are predisposed to viral and bacterial infections resulting in potentially fatal acute exacerbations. chronic obstructive pulmonary disease is defined as a lung disease characterised by obstruction to lung airflow that interferes with normal breathing. antibiotic therapy has not been particularly useful in eradicating bacteria such as non-typeable haemophilus influenzae (nthi) because the ... | 2017 | 28626902 |
| haemophilus influenzae type a meningitis in immunocompetent child, oman, 2015. | meningitis caused by haemophilus influenzae type b (hib) was eliminated in oman after the introduction of hib vaccine in 2001. however, a case of h. influenzae type a meningitis was diagnosed in a child from oman in 2015, which highlights the need to monitor the incidence of invasive non-hib h. influenzae disease. | 2017 | 28628438 |
| epidemiological features and antibiotic resistance patterns of haemophilus influenzae originating from respiratory tract and vaginal specimens in pediatric patients. | haemophilus influenzae (h. influenzae) is a common pathogen of respiratory tract infections in children, however, as a possible cause of vulvovaginitis in prepubertal girls, its epidemiological features, antibiotic-resistance patterns, and treatment are seldom noted. design, setting, participants, interventions, and main outcome measures: specimens obtained from patients were inoculated on haemophilus selective medium; and drug-sensitivities tests were determined using the disk diffusion method. ... | 2017 | 28629795 |
| multipathogenic necrotising supraglottitis in an immunocompetent patient. | supraglottitis is a potentially life-threatening condition. it is now uncommon due to the haemophilus influenzae type b vaccination and is more recently caused by streptococcus pneumoniae, s. pyogenes, h. influenzae non-type b, h. parainfluenzae, staphylococcus aureus and pasteurella multocida very rarely, it can cause necrotising supraglottitis/epiglottitis, and this has been reported in immunocompromised individuals. we present a unique case of multipathogenic supraglottitis causing laryngeal ... | 2017 | 28630241 |
| rapid differentiation of haemophilus influenzae and haemophilus haemolyticus by use of matrix-assisted laser desorption ionization-time of flight mass spectrometry with clinprotools mass spectrum analysis. | haemophilus influenzae is associated with severe invasive disease, while haemophilus haemolyticus is considered part of the commensal flora in the human respiratory tract. although the addition of a custom mass spectrum library into the matrix-assisted laser desorption ionization-time of flight mass spectrometry (maldi-tof ms) system could improve identification of these two species, the establishment of such a custom database is technically complicated and requires a large amount of resources, ... | 2017 | 28637909 |
| haemophilus influenzae peritonitis in a girl on automated peritoneal dialysis: case report and review of the literature. | haemophilus influenzae is a rare cause of peritonitis in patients on peritoneal dialysis (pd). we report a case of peritonitis due to non-typeable h. influenzae in a 5-year-old girl on automated pd. the patient was successfully treated with intraperitoneal cefepime and cefazolin. the isolate was multilocus sequence type 3 and contained the hmw and hia genes but was is1016-negative. seven of the eight reported cases were female, indicating that sex-associated factors may be important in h. influe ... | 2017 | 28660129 |
| prevalence and antibiotic resistance profiles of cerebrospinal fluid pathogens in children with acute bacterial meningitis in yunnan province, china, 2012-2015. | acute bacterial meningitis is still considered one of the most dangerous infectious diseases in children. to investigate the prevalence and antibiotic resistance profiles of cerebrospinal fluid (csf) pathogens in children with acute bacterial meningitis in southwest china, csf samples from 179 meningitis patients (3 days to 12 years old) with positive culture results were collected from 2012 to 2015. isolated pathogens were identified using the vitek-32 system. gram stain results were used to gu ... | 2017 | 28662145 |
| the changing epidemiology of invasive haemophilus influenzae disease: emergence and global presence of serotype a strains that may require a new vaccine for control. | more than two decades after the implementation of the hib conjugate vaccine in north america, haemophilus influenzae serotype a (hia) has emerged as a significant cause of invasive disease in indigenous communities. however, little is known about the global presence of this pathogen. | 2017 | 28666758 |
| infection by streptococcus pneumoniae in children with or without radiologically confirmed pneumonia. | community-acquired pneumonia is an important cause of morbidity in childhood, but the detection of its causative agent remains a diagnostic challenge. the authors aimed to evaluate the role of the chest radiograph to identify cases of community-aquired pneumonia caused by typical bacteria. | 2017 | 28668258 |
| 10-valent pneumococcal conjugate vaccine (pcv10) decreases metabolic activity but not nasopharyngeal carriage of streptococcus pneumoniae and haemophilus influenzae. | the effect of pneumococcal vaccination is widely variable when measured by nasopharyngeal carriage of vaccine and non-vaccine targets. the aim of this study was to compare the carriage rates and metabolic activity of streptococcus pneumoniae, staphylococcus aureus, haemophilus influenzae and moraxella catarrhalis among children who were or were not vaccinated with pcv10. | 2017 | 28668567 |
| nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of japanese society of chemotherapy, the japanese association for infectious diseases, and the japanese society for clinical microbiology in 2012: general view of the pathogens' antibacterial susceptibility. | the nationwide surveillance on antimicrobial susceptibility of bacterial respiratory pathogens from the patients in japan was conducted by japanese society of chemotherapy, japanese association for infectious diseases and japanese society for clinical microbiology in 2012. the isolates were collected from clinical specimens obtained from well-diagnosed adult patients with respiratory tract infections during the period between january and december in 2012 by three societies. antimicrobial suscept ... | 2017 | 28669567 |
| haemophilus parainfluenzae strain atcc 33392 forms biofilms in vitro and during experimental otitis media infections. | haemophilus parainfluenzae is a nutritionally fastidious, gram-negative bacterium with an oropharyngeal/nasopharyngeal carriage niche that is associated with a range of opportunistic infections, including infectious endocarditis and otitis media (om). these infections are often chronic/recurrent in nature and typically involve bacterial persistence within biofilm communities that are highly resistant to host clearance. this study addresses the primary hypothesis that h. parainfluenzae forms biof ... | 2017 | 28674033 |
| infusion of sibling marrow in a patient with purine nucleoside phosphorylase deficiency leads to split mixed donor chimerism and normal immunity. | purine nucleoside phosphorylase (pnp) deficiency, a rare autosomal recessive metabolic disease causes combined immunodeficiency and developmental delay, hypotonia, and spasticity. patients present with recurrent infections associated with t-lymphocytopenia, characteristically presenting later than patients with classical severe combined immunodeficiency (scid). pnp, with adenosine deaminase (ada), is part of the purine salvage pathway. the only curative therapy is hematopoietic stem cell transpl ... | 2017 | 28674683 |
| synthesis and antibacterial activity of novel lincomycin derivatives. iii. optimization of a phenyl thiadiazole moiety. | lincomycin derivatives that have a 5-(2-nitrophenyl)-1,3,4-thiadiazol-2-yl thio moiety at the 7-position were synthesized. 5-substituted 2-nitrophenyl derivatives showed potent antibacterial activities against streptococcus pneumoniae and streptococcus pyogenes with erm gene. antibacterial activities of the 4,5-di-substituted 2-nitrophenyl derivatives were generally comparable to those of telithromycin (tel) against s. pneumoniae with erm gene and clearly superior to those of tel against s. pyog ... | 2017 | 28676716 |
| inactivation of the thymidylate synthase thya in non-typeable haemophilus influenzae modulates antibiotic resistance and has a strong impact on its interplay with the host airways. | antibacterial treatment with cotrimoxazol (txs), a combination of trimethoprim and sulfamethoxazole, generates resistance by, among others, acquisition of thymidine auxotrophy associated with mutations in the thymidylate synthase gene thya, which can modify the biology of infection. the opportunistic pathogen non-typeable haemophilus influenzae (nthi) is frequently encountered in the lower airways of chronic obstructive pulmonary disease (copd) patients, and associated with acute exacerbation of ... | 2017 | 28676846 |
| secondary bacterial infections associated with influenza pandemics. | lower and upper respiratory infections are the fourth highest cause of global mortality (lozano et al., 2012). epidemic and pandemic outbreaks of respiratory infection are a major medical concern, often causing considerable disease and a high death toll, typically over a relatively short period of time. influenza is a major cause of epidemic and pandemic infection. bacterial co/secondary infection further increases morbidity and mortality of influenza infection, with streptococcus pneumoniae, ha ... | 2017 | 28690590 |
| nontypeable haemophilus influenzae releases dna and dnabii proteins via a t4ss-like complex and come of the type iv pilus machinery. | biofilms formed by nontypeable haemophilus influenzae (nthi) are central to the chronicity, recurrence, and resistance to treatment of multiple human respiratory tract diseases including otitis media, chronic rhinosinusitis, and exacerbations of both cystic fibrosis and chronic obstructive pulmonary disease. extracellular dna (edna) and associated dnabii proteins are essential to the overall architecture and structural integrity of biofilms formed by nthi and all other bacterial pathogens tested ... | 2017 | 28696280 |
| age-appropriate versus up-to-date coverage of routine childhood vaccinations among young children in israel. | routine childhood vaccinations schedules recommend that children receive the vaccine doses at specific ages. vaccination coverage data are conventionally reported by the up-to-date method. we aimed to assess vaccination timeliness by the age-appropriate method and compare with the up-to-date vaccination coverage. | 2017 | 28696824 |
| d-methionine interferes with non-typeable haemophilus influenzae peptidoglycan synthesis during growth and biofilm formation. | non-typeable haemophilus influenzae (nthi) is an opportunistic pathogen that plays a major role in a number of respiratory tract infections, including otitis media, cystic fibrosis and chronic obstructive pulmonary disease. biofilm formation has been implicated in both nthi colonization and disease, and is responsible for the increased tolerance of this pathogen towards antibiotic treatment. targeting metabolic pathways that are important in nthi biofilm formation represents a potential strategy ... | 2017 | 28699879 |
| overall effectiveness of pneumococcal conjugate vaccines: an economic analysis of phid-cv and pcv-13 in the immunization of infants in italy. | pneumococcal diseases are associated with a significant clinical and economic burden. the 7-valent pneumococcal conjugate vaccine (pcv-7) has been used for the immunization of newborns against invasive pneumococcal diseases (ipd) in italy while now the pneumococcal non-typeable haemophilus influenzae protein d conjugate vaccine (phid-cv) and the 13-valent pneumococcal conjugate vaccine (pcv-13) are available. the aim of this analysis was to compare the estimated health benefits, cost and cost-ef ... | 2017 | 28700264 |
| a high seroprevalence of antibodies to pertussis toxin among japanese adults: qualitative and quantitative analyses. | in 2013, national serosurveillance detected a high seroprevalence of antibodies to pertussis toxin (pt) from bordetella pertussis among japanese adults. thus, we aimed to determine the cause(s) of this high seroprevalence, and analyzed the titers of antibodies to pt and filamentous hemagglutinin (fha) among adults (35-44 years old), young children (4-7 years old), and older children (10-14 years old). our quantitative analyses revealed that adults had higher seroprevalences of anti-pt igg and pt ... | 2017 | 28700751 |
| geographic consistency in dominant, non-typeable haemophilus influenzae genotypes colonising four distinct australian paediatric groups: a cohort study. | non-typeable haemophilus influenzae (nthi)-associated ear and respiratory diseases (including pneumonia) represent a major health burden in many parts of the world. nthi strains retrieved from the upper airways commonly reflect those found in the lower airways. despite growing genomic and genotyping data on nthi, there remains a limited understanding of global and regional nthi population structures. the aim of this study was to determine whether nasopharyngeal carriage in four australian paedia ... | 2016 | 28702292 |
| childhood pneumonia and meningitis in the eastern highlands province, papua new guinea in the era of conjugate vaccines: study methods and challenges. | pneumonia and meningitis are common causes of severe childhood illness in papua new guinea (png). the etiology of both clinical conditions in png has not been recently assessed. changes in lifestyle, provision and access to healthcare, antimicrobial utilization and resistance, and the national childhood vaccination schedule necessitate reassessment. | 2017 | 28702307 |
| the evidence for non-typeable haemophilus influenzae as a causative agent of childhood pneumonia. | haemophilus influenzae type b (hib) was a major cause of bacterial pneumonia in children prior to the introduction of hib-conjugate vaccines. the widespread use of hib-conjugate vaccines has resulted in a significant decline in the number of cases of invasive hib disease, including bacteraemic pneumonia, in areas where the vaccine has been implemented. in many countries, non-typeable h. influenzae (nthi) is now the most common cause of invasive haemophilus infection in all ages. nthi are a recog ... | 2017 | 28702311 |