Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| antibacterial defense of human airway epithelial cells from chronic obstructive pulmonary disease patients induced by acute exposure to nontypeable haemophilus influenzae: modulation by cigarette smoke. | antimicrobial proteins and peptides (amps) are a central component of the antibacterial activity of airway epithelial cells. it has been proposed that a decrease in antibacterial lung defense contributes to an increased susceptibility to microbial infection in smokers and patients with chronic obstructive pulmonary disease (copd). however, whether reduced amp expression in the epithelium contributes to this lower defense is largely unknown. we investigated the bacterial killing activity and expr ... | 2017 | 28171878 |
| the crystal structure of pd1, a haemophilus surface fibril domain. | the haemophilus surface fibril (hsf) is an unusually large trimeric autotransporter adhesin (taa) expressed by the most virulent strains of h. influenzae. hsf is known to mediate adhesion between pathogen and host, allowing the establishment of potentially deadly diseases such as epiglottitis, meningitis and pneumonia. while recent research has suggested that this taa might adopt a novel `hairpin-like' architecture, the characterization of hsf has been limited to in silico modelling and electron ... | 2017 | 28177321 |
| etiology of acute otitis media and serotype distribution of streptococcus pneumoniae and haemophilus influenzae in chilean children <5 years of age. | the impact of bacterial conjugate vaccines on acute otitis media (aom) is affected by several factors including population characteristics, bacterial etiology and vaccine conjugation method, carrier, and coverage. this study estimated the baseline etiology, distribution, and antibiotic susceptibility of bacterial serotypes that causes aom in children aged <5 years in a public setting in santiago, chile.children aged ≥3 months and <5 years referred to the physician for treatment of aom episodes ( ... | 2017 | 28178138 |
| the impact of prenatal exposure to parasitic infections and to anthelminthic treatment on antibody responses to routine immunisations given in infancy: secondary analysis of a randomised controlled trial. | chronic parasitic infections are associated with active immunomodulation which may include by-stander effects on unrelated antigens. it has been suggested that pre-natal exposure to parasitic infections in the mother impacts immunological development in the fetus and hence the offspring's response to vaccines, and that control of parasitic infection among pregnant women will therefore be beneficial. | 2017 | 28178298 |
| invasive haemophilus influenzae infection in patients with cancer. | a major cause of morbidity and mortality in patients with cancer is infection. since the introduction of the haemophilus influenzae type b (hib) vaccine in the united states in the 1990s, invasive h influenzae infection has become less common. we report on 5 patients with cancer and invasive h influenzae infection. a literature review was also performed of the dominant haemophilus subtype and the clinical features associated with the infection and concomitant cancer. of the 17 cases found in the ... | 2017 | 28178716 |
| serum resistance and phase variation of a nasopharyngeal non-typeable haemophilus influenzae isolate. | haemophilus influenzae harbours a complex array of factors to resist human complement attack. as non-typeable h. influenzae (nthi) strains do not possess a capsule, their serum resistance mainly depends on other mechanisms including los decoration. in this report, we describe the identification of a highly serum resistant, nasopharyngeal isolate (nthi23) by screening a collection of 77 clinical isolates. for nthi23, we defined the mlst sequence type 1133, which matches the profile of a previousl ... | 2017 | 28179078 |
| modeling the potential for vaccination to diminish the burden of invasive non-typhoidal salmonella disease in young children in mali, west africa. | in sub-saharan africa, systematic surveillance of young children with suspected invasive bacterial disease (e.g., septicemia, meningitis) has revealed non-typhoidal salmonella (nts) to be a major pathogen exhibiting high case fatality (~20%). where infant vaccination against haemophilus influenzae type b (hib) and streptococcus pneumoniae has been introduced to prevent invasive disease caused by these pathogens, as in bamako, mali, their burden has decreased markedly. in parallel, nts has become ... | 2017 | 28182657 |
| do we need a vaccine against moraxella catarrhalis in chronic lung disease? what are the options and opportunities? | moraxella catarrhalis is the second most common cause of exacerbations in adults with copd, resulting in enormous morbidity and mortality in this clinical setting. vaccine development for m. catarrhalis has lagged behind the other two important causes of exacerbations in copd, nontypeable haemophilus influenzae and streptococcus pneumoniae. while no licensed vaccine is currently available for m. catarrhalis, several promising candidate vaccine antigens have been identified and characterized and ... | 2017 | 28185742 |
| increased glycosylation efficiency of recombinant proteins in escherichia coli by auto-induction. | escherichia coli cells have been considered as promising hosts for producing n-glycosylated proteins since the successful production of n-glycosylated protein in e. coli with the pgl (n-linked protein glycosylation) locus from campylobacter jejuni. however, one hurdle in producing n-glycosylated proteins in large scale using e. coli is inefficient glycan glycosylation. in this study, we developed a strategy for the production of n-glycosylated proteins with high efficiency via an optimized auto- ... | 2017 | 28188786 |
| adherence to vaccination guidelines post splenectomy: a five year follow up study. | following a splenectomy patients are at increased risk of significant infections. in its most severe form, overwhelming post-splenectomy infection (opsi) has a mortality rate of up to 80%. in this study we aim to establish the adherence to vaccination and antibiotic national guidelines in splenectomised patients. a retrospective study of 100 patients who underwent splenectomy (21 emergency, 79 elective), in two teaching hospitals was undertaken over a five-year period. patients were followed up ... | 2017 | 28189514 |
| diagnosis of primary antibody and complement deficiencies in young adults after a first invasive bacterial infection. | screening for primary immunodeficiencies (pids) in adults is recommended after two severe bacterial infections. we aimed to evaluate if screening should be performed after the first invasive infection in young adults. | 2017 | 28192236 |
| recommended immunization schedule for children and adolescents: immunization guideline (8th edition) released by the korean pediatric society in 2015. | this report includes the recommended immunization schedule table for children and adolescents based on the 8th (2015) and revised 7th (2012) immunization guidelines released by the committee on infectious diseases of the korean pediatric society (kps). notable revised recommendations include: reorganization of the immunization table with a list of vaccines on the vertical axis and the corresponding age on the horizontal axis; reflecting the inclusion of haemophilus influenzae type b vaccine, pne ... | 2016 | 28194210 |
| prophylactic antipyretics for prevention of febrile seizures following vaccination. | question parents of a 12-month-old boy are bringing their son in to my family practice clinic for his well-baby visit. as the infant is due for his 12-month vaccine series, the parents are concerned after hearing about the association between certain vaccinations and an increased risk of febrile seizures, and are wondering if they should administer prophylactic antipyretics to decrease the risk of febrile seizure. what vaccinations are associated with increased risk of febrile seizure, and is th ... | 2017 | 28209678 |
| question les parents d’un petit garçon de 12 mois accompagnent leur fils à ma pratique familiale pour sa visite de puériculture. comme l’enfant est dû pour sa série vaccinale de 12 mois, les parents s’inquiètent parce qu’ils ont entendu parler d’un lien entre certains vaccins et un risque accru de convulsions fébriles, et ils se demandent s’ils devraient administrer un antipyrétique en prophylaxie pour réduire le risque. quels vaccins sont liés à un risque accru de convulsions fébriles, et exist ... | 2017 | 28209698 | |
| splenectomy as a destination: improving quality of care among asplenic veterans through a travel clinic. | asplenic patients are at risk for severe infections, but adherence to recommended preventive education and vaccination is poor. the goal of this study was to demonstrate that a targeted intervention can improve vaccination rates in a population of asplenic veterans. | 2017 | 28213046 |
| biofilm formation of achromobacter xylosoxidans on contact lens. | achromobacter spp. may contaminate lenses, lens cases, and contact lens solutions and cause ocular infections. the aim of this study was to investigate the possibility of isolated strain of achromobacter xylosoxidans to form biofilm on the surface of soft contact lenses (cl), to quantify the production of the formed biofilm, and compare it with the reference strains (pseudomonas aeruginosa, staphylococcus aureus, and haemophilus influenzae). bacterial strain isolated from one contact lens case w ... | 2017 | 28218002 |
| epidemiology of invasive haemophilus influenzae disease, europe, 2007-2014. | we describe the epidemiology of invasive haemophilus influenzae disease during 2007-2014 in 12 european countries and assess overall h. influenzae disease trends by serotype and patient age. mean annual notification rate was 0.6 cases/100,000 population, with an increasing annual trend of 3.3% (95% ci 2.3% to 4.3%). the notification rate was highest for patients <1 month of age (23.4 cases/100,000 population). nontypeable h. influenzae (nthi) caused 78% of all cases and showed increasing trends ... | 2017 | 28220749 |
| effect of stepwise perinatal immunization education: a cluster-randomized controlled trial. | perinatal immunization education is important for improving the immunization outcomes of infants; however, the content of educational materials used at each perinatal period has not been carefully evaluated. we hypothesized that stepwise education offered at different perinatal periods would improve infant immunization status and enhance maternal immunization knowledge. | 2017 | 28222999 |
| evaluation of antibacterial potential and toxicity of plant volatile compounds using new broth microdilution volatilization method and modified mtt assay. | with aim to develop effective proof-of-concept approach which can be used in a development of new preparations for the inhalation therapy, we designed a new screening method for simple and rapid simultaneous determination of antibacterial potential of plant volatiles in the liquid and the vapour phase at different concentrations. in addition, eva (ethylene vinyl acetate) capmat™ as vapour barrier cover was used as reliable modification of thiazolyl blue tetrazolium bromide (mtt) assay for cytoto ... | 2017 | 28223069 |
| surveillance of omadacycline activity tested against clinical isolates from a global (north america, europe, latin america and asia-western pacific) collection (2010-2011). | omadacycline is a broad spectrum aminomethylcycline in late-stage clinical development for acute bacterial skin and skin structure infections and community-acquired pneumonia as both an oral and intravenous, once-daily formulation. in this report omadacycline and comparators were tested against 69,246 non-duplicate bacterial isolates collected prospectively during 2010 and 2011 from medical centers in asia-pacific (11,397 isolates), europe (23,490 isolates), latin america (8,038 isolates) and no ... | 2017 | 28223386 |
| invasive haemophilus influenzae disease in the vaccine era in rio de janeiro, brazil. | haemophilus influenzae (hi) serotype b (hib) conjugate vaccine was incorporated into the infant immunisation schedule in brazil in 1999, where hib was one of the major etiologic sources of community-acquired bacterial meningitis. | 2017 | 28225898 |
| invasive haemophilus influenzae disease in the vaccine era in rio de janeiro, brazil. | haemophilus influenzae (hi) serotype b (hib) conjugate vaccine was incorporated into the infant immunisation schedule in brazil in 1999, where hib was one of the major etiologic sources of community-acquired bacterial meningitis. | 2017 | 28225904 |
| three case reports of post immunization and post viral bullous pemphigoid: looking for the right trigger. | bullous pemphigoid (bp) is a blistering skin disorder infrequent in infancy and rarely reported in medical literature. | 2017 | 28228112 |
| comparison of pathogen eradication rate and safety of anti-bacterial agents for bronchitis: a network meta-analysis. | a large number of population in both developing and developed countries are affected by bronchitis, among all the factors, bacterial infection was considered as a critical cause of acute exacerbations of chronic bronchitis. although several anti-bacterial agents were proved to have the effect of alleviating bronchitis, their relative efficacies and potential side effects remained not clear. we are keen to compare the pathogen eradication rate and safety of anti-bacterial agents for bronchitis. | 2017 | 28230273 |
| pro-inflammatory cytokines impair vitamin d-induced host defense in cultured airway epithelial cells. | vitamin d is a regulator of host defense against infections and induces expression of the antimicrobial peptide hcap18/ll-37. vitamin d deficiency is associated with chronic inflammatory lung diseases and respiratory infections. however, it is incompletely understood if and how (chronic) airway inflammation affects vitamin d metabolism and action. we hypothesized that long-term exposure of primary bronchial epithelial cells (pbec) to pro-inflammatory cytokines alters their vitamin d metabolism, ... | 2017 | 28231019 |
| characteristics of invasive haemophilus influenzae serotype a (hia) from nunavik, canada and comparison with hia strains in other north american arctic regions. | this study examines the microbiological characteristics of invasive haemophilus influenae serotype a (hia) isolates from nunavik (northern quebec), canada. the relationship between invasive hia isolates from nunavik, nunavut, canada, and alaska, usa will be discussed. | 2017 | 28232014 |
| bacterial aetiology and mortality in copd patients with cap: results from the german competence network, capnetz. | community-acquired pneumonia (cap) is a major cause of morbidity and mortality, and chronic obstructive pulmonary disease (copd) is a frequent comorbidity. the bacterial aetiology of cap-copd and its possible associations with serum markers and mortality are incompletely understood. | 2017 | 28234091 |
| use of cerebrospinal fluid and serum samples impregnated on ftatm elute filter paper for the diagnosis of infections caused by neisseria meningitidis, streptococcus pneumoniae and haemophilus influenzae. | the lack of information regarding the burden of acute bacterial meningitis in latin america leads to a reduction in the estimated incidence rates of the disease, and impairs public health decisions on the use and follow-up of preventive interventions, particularly, the evaluation of existing vaccination policies. the use of the real-time pcr in diagnostic routine procedures has resulted in a substantial increase in confirmed bacterial meningitis cases. however, in resource-poor countries, these ... | 2017 | 28235065 |
| characteristics of ci children with complicated middle ear infections. | to describe cases of complicated middle ear infections in children with cochlear implants (ci), i.e., episodes of acute otitis media (aom) and acute mastoiditis (am), resulting in hospitalization. | 2017 | 28235386 |
| patients hospitalized with an infective exacerbation of bronchiectasis unrelated to cystic fibrosis: clinical, physiological and sputum characteristics. | bronchiectasis is a growing health burden both globally and in australasia. associated with repeated respiratory infections, the disease often results in hospital admission, impaired quality of life, reduced lung function and shortened life expectancy. we describe the local clinical, physiological and sputum characteristics in patients hospitalized with an infective exacerbation of bronchiectasis. | 2017 | 28236369 |
| effect of ebola virus disease on maternal and child health services in guinea: a retrospective observational cohort study. | the 2014 west african epidemic of ebola virus disease posed a major threat to the health systems of the countries affected. we sought to quantify the consequences of ebola virus disease on maternal and child health services in the highly-affected forest region of guinea. | 2017 | 28237252 |
| simultaneous detection of nine key bacterial respiratory pathogens using luminex xtag(®) technology. | early diagnosis and treatment are crucial to the outcome of lower respiratory tract infections (lrtis). in this study, we developed an assay combining multiplex pcr and luminex technology (mplt) for the detection of nine important respiratory bacterial pathogens, which frequently cause lrtis. these were streptococcus pneumoniae, moraxella catarrhalis, staphylococcus aureus, streptococcus pyogenes, haemophilus influenzae, mycoplasma pneumoniae, legionella spp., pseudomonas aeruginosa, and klebsie ... | 2017 | 28241513 |
| an isolate of haemophilus haemolyticus produces a bacteriocin-like substance that inhibits the growth of nontypeable haemophilus influenzae. | nontypeable haemophilus influenzae (nthi) frequently colonises the upper respiratory tract and is an important cause of respiratory infections. resistance to antibiotics is an emerging trend in nthi and alternative prevention or treatment strategies are required. haemophilus haemolyticus is a common commensal occupying the same niche as nthi and, if able to produce substances that inhibit nthi growth, may have a role as a probiotic. in this study, ammonium sulphate extracts from broth culture of ... | 2017 | 28242259 |
| biodegradation of picolinic acid by a newly isolated bacterium alcaligenes faecalis strain jq135. | we isolated a bacterial strain jq135 from municipal wastewater, which was capable of efficiently degrading picolinic acid (pa). based on the physico-biochemical characteristics and 16s rdna analysis, strain jq135 was identified as alcaligenes faecalis. in addition, strain jq135 produced an orange pigment when cultured in the luria-bertani medium, which is different from the previously reported strains of a. faecalis. during the degradation of pa by the resting strain jq135 cells, only one interm ... | 2017 | 28243718 |
| designing novel construction for cell surface display of protein e on escherichia coli using non-classical pathway based on lpp-ompa. | today, transference of recombinant protein on the outer surface of bacteria is deemed as a valuable process for various applications in biotechnology including preparation of vaccines. in this study, lpp-ompa structure was used to present outer membrane protein e of haemophilus influenzae on e. coli outer membrane. also, a structure was designed according to lpp-ompa based on non-classical secretion pathway using bioinformatics software such as memsat-svm, scrotump and signalp where it lacked an ... | 2017 | 28247289 |
| a rare case of candida epiglottitis in an immunocompetent child. | we present a case of acute candida epiglottitis in an otherwise healthy and haemophilus influenzae type b-immunized 4-year-old child. a query of the literature reveals this disease to be commonly found in patients who are immunocompromised by problems including human immunodeficiency virus disease and lymphoma and leukemia. however, there are no published reports of acute candida epiglottitis in immunocompetent and vaccinated patients. our case should emphasize to the emergency physician the nee ... | 2017 | 28248840 |
| fluorocycline tp-271 is potent against complicated community-acquired bacterial pneumonia pathogens. | tp-271 is a novel, fully synthetic fluorocycline antibiotic in clinical development for the treatment of respiratory infections caused by susceptible and multidrug-resistant pathogens. tp-271 was active in mic assays against key community respiratory gram-positive and gram-negative pathogens, including streptococcus pneumoniae (mic90 = 0.03 µg/ml), methicillin-sensitive staphylococcus aureus (mssa; mic90 = 0.25 µg/ml), methicillin-resistant s. aureus (mrsa; mic90 = 0.12 µg/ml), streptococcus pyo ... | 2017 | 28251179 |
| non-typeable haemophilus influenzae infection of the junbo mouse. | acute otitis media, inflammation of the middle ear bulla, is the most common bacterial infection in children. for one of the principal otopathogens, non-typeable haemophilus influenzae (nthi), animal models allow us to investigate host-microbial interactions relevant to the onset and progression of infection and to study treatment of middle ear disease. we have established a robust model of nthi middle ear infection in the junbo mouse. intranasal inoculation with nthi produces high rates of bull ... | 2017 | 28252201 |
| design, synthesis and structure-bactericidal activity relationships of novel 9-oxime ketolides and reductive epimers of acylides. | erythromycin was long viewed as a bacteriostatic agent. the erythromycin derivatives, 9-oxime ketolides have a species-specific bactericidal profile. among them, the 3'-allyl version of the 9-oxime ketolide 1 (ar=3-quinolyl; 17a) is bactericidal against streptococcus pneumoniae and streptococcus pyogenes. in contrast, the 2-fluoro analogs of 1, 13a (ar=6-quinolyl), 13b (ar=3-quinolyl) and 24a (ar=4-isoquinolyl), show bactericidal activities against s. pneumoniae, staphylococcus aureus and moraxe ... | 2017 | 28256375 |
| nonantibiotic macrolides restore airway macrophage phagocytic function with potential anti-inflammatory effects in chronic lung diseases. | we reported defective efferocytosis associated with cigarette smoking and/or airway inflammation in chronic lung diseases, including chronic obstructive pulmonary disease, severe asthma, and childhood bronchiectasis. we also showed defects in phagocytosis of nontypeable haemophilus influenzae (nthi), a common colonizer of the lower airway in these diseases. these defects could be substantially overcome with low-dose azithromycin; however, chronic use may induce bacterial resistance. the aim of t ... | 2017 | 28258107 |
| community analysis of dental plaque and endotracheal tube biofilms from mechanically ventilated patients. | mechanically ventilated patients are at risk for developing ventilator-associated pneumonia, and it has been reported that dental plaque provides a reservoir of respiratory pathogens that may aspirate to the lungs and endotracheal tube (ett) biofilms. for the first time, metataxonomics was used to simultaneously characterize the microbiome of dental plaque, etts, and non-directed bronchial lavages (nbls) in mechanically ventilated patients to determine similarities in respective microbial commun ... | 2017 | 28259058 |
| characterisation of invasive clinical haemophilus influenzae isolates in queensland, australia using whole-genome sequencing. | haemophilus influenzae is an important aetiological organism of both adult and child respiratory disease. the number of non-typeable (nthi) invasive h. influenzae isolates referred to the queensland (qld) public health microbiology laboratory has increased notably year-by-year. in this study we used whole-genome sequencing to molecularly characterise 100 referred invasive h. influenzae, including 74 nthi isolates over a 15-year period, observing the carriage of capsular and putative virulence ge ... | 2017 | 28260537 |
| persistent and recurrent bacterial bronchitis-a paradigm shift in our understanding of chronic respiratory disease. | the recent recognition that the conducting airways are not "sterile" and that they have their own dynamic microbiome, together with the rapid advances in our understanding of microbial biofilms and their roles in the causation of respiratory diseases (such as chronic bronchitis, sinusitis, and chronic otitis media), permit us to update the "vicious circle" hypothesis of the causation of bronchiectasis. this proposes that chronic inflammation driven by persistent bacterial bronchitis (pbb) causes ... | 2017 | 28261574 |
| il-33/st2 immune responses to respiratory bacteria in pediatric asthma. | here we investigated the relationship between local bacterial colonization and anti-bacterial immune responses in pre-school asthmatic and control children within the eu-wide study predicta. in this cohort of pre-school asthmatic children, nasopharyngeal colonization with gram-negative bacteria such as haemophilus influenzae and moraxella catarrhalis was found to be associated with the highest interferon beta (ifnβ) and il-33 levels in the nasal pharyngeal fluids (npf). il33r-st2 was found induc ... | 2017 | 28262704 |
| the immunogenicity and safety of a hib-menac vaccine: a non-inferiority randomized, observer-blind trial in infants aged 3-5 months. | the objective of this study was to evaluate the immunogenicity and safety of the novel combined haemophilus influenzae type b-neisseria meningitidis serogroup a and c-tetanus toxoid conjugate vaccine (hib-menac). | 2017 | 28277801 |
| infective endocarditis risk after percutaneous pulmonary valve implantation with the melody and sapien valves. | this study compared the risk of infective endocarditis (ie) after percutaneous pulmonary valve implantation (ppvi) with the sapien and melody valves. | 2017 | 28279319 |
| nontypeable haemophilus influenzae-promoted proliferation of kras-induced early adenomatous lesions is completely dependent on toll-like receptor signaling. | chronic obstructive pulmonary disease is a risk factor for lung cancer. copd is characterized by chronic airway inflammation and lung infections. the airways of patients with copd are frequently colonized with bacteria [eg, nontypeable haemophilus influenzae (nthi)] that cause pulmonary inflammation and exacerbations. pulmonary adenocarcinomas are frequently associated with an activating mutation in the kras gene. we determined the function of toll-like receptor (tlr) signaling on the progressio ... | 2017 | 28279655 |
| prevention of influenza virus induced bacterial superinfection by standardized echinacea purpurea, via regulation of surface receptor expression in human bronchial epithelial cells. | viral infections may predispose the airways to secondary bacterial infections that can lead to unfavorable progression of principally self-limiting illnesses. such complicated respiratory infections include pneumonia, bronchitis, sinusitis, acute otitis media, and sepsis, which cause high morbidity and lethality. some of the pathogenic consequences of viral infections, like the expression of bacterial adhesion receptors and the disturbance of physical barrier integrity due to inflammation, may c ... | 2017 | 28279802 |
| discharge and infection in retinoblastoma post-enucleation sockets. | to investigate the causes and treatment options for socket discharge and infection in patients enucleated for retinoblastoma (rb). | 2017 | 28280296 |
| haemophilus influenzae isolated from men with acute urethritis: its pathogenic roles, responses to antimicrobial chemotherapies, and antimicrobial susceptibilities. | there have been few comprehensive studies on haemophilus influenza-positive urethritis. | 2017 | 28282645 |
| rhinovirus-bacteria co-exposure synergistically induces ccl20 production from human bronchial epithelial cells. | exacerbations of chronic obstructive pulmonary disease (copd) are triggered by viral or bacterial pathogens, with human rhinovirus (hrv) and nontypeable haemophilus influenzae (nthi) among the most commonly detected pathogens. patients who suffer from concomitant viral and bacterial infection have more severe exacerbations. the airway epithelial cell is the initial site of viral and bacterial interactions, and ccl20 is an epithelial chemokine that attracts immature dendritic cells to the airways ... | 2017 | 28283475 |
| bacteria associated with marginal zone lymphomas. | in the last decades some bacteria have been associated with a various extent with marginal zone (extra nodal, nodal and splenic types) lymphomas are frequently associated with chronic infections, with important clinical, molecular, biological, and therapeutic implications. the well-known correlation between helicobacter pylori and gastric malt-lymphoma, the recently reported links between chlamydia psittaci and ocular adnexal malt-lymphoma and borrelia burgdorferi and cutaneous malt lymphoma con ... | 2017 | 28288714 |
| [postoperative pulmonary disease associated with haemophilus influenzae and neisseria meningitidis in a diabetic child]. | haemophilus influenzae is a saprophyte that colonizes the nasopharynx in nearly two thirds of children and adults. neisseria meningitidis is a strict human bacterium which lives in the nasopharynx. it can cause benign nasopharyngitis or asymptomatic colonization. we report the case of a diabetic child with postoperative pneumonia associated with haemophilus influenzae and neisseria meningitidis. a 3-year old diabetic patient admitted to the department of cardiac surgery due to delayed surgical t ... | 2016 | 28292047 |
| burden and spectrum of bacterial infections among sickle cell disease children living in cameroon. | although sickle cell disease (scd) children are highly susceptible to bacterial infections (bis), there is a dreadful lack of data related to the burden and spectrum of bis in sub-saharan africa (ssa), the highest affected region with scd. this study aimed to determine the burden and spectrum of bis among scd children hospitalized in a pediatric reference hospital in cameroon, a ssa country. | 2017 | 28298206 |
| purulent pericarditis as a complication of bacteraemic enterococcus faecalis urinary tract infection. | purulent pericarditis is a rare clinical entity in the modern antibiotic era. the most common portal of entry is thought to be direct extension from a primary lung source and is usually caused by staphylococcus aureus, streptococcus pneumoniae or haemophilus influenzae we report the case of a man aged 69 years who presented with purulent pericarditis due to enterococcus faecalis likely caused by haematogenous spread from a urinary tract source. urgent pericardiocentesis was vital and restored hi ... | 2017 | 28298381 |
| antimicrobial peptide levels are linked to airway inflammation, bacterial colonisation and exacerbations in chronic obstructive pulmonary disease. | antimicrobial peptides (amps) are effectors of host defence against infection, inflammation and wound repair. we aimed to study amp levels in stable chronic obstructive pulmonary disease (copd) and during acute exacerbations of copd (aecopd), and to examine their relation to clinical parameters and inflammatory markers.the 3-year bergen copd cohort study included 433 copd patients and 325 controls. induced sputum was obtained and analysed for levels of the amps human cathelicidin (hcap18/ll-37) ... | 2017 | 28298400 |
| hypotonic-hyporesponsive episodes after administration of hexavalent dtp-based combination vaccine: a description of 12 cases. | hypotonic-hyporesponsive (hhe) episodes are known and recognized phenomena, which typically occur within 48 hours of immunisation..our aim is to describe 12 cases of hhe brought to the center of pediatric sleep medicine, with attention to the clinical features of the episode and their follow-up. medical charts of infants visited between 2005-2015 were reviewed. twelve infants showed a hhe using hhe using brighton collaboration criteria. all infants received a hexavalent diphtheria -tetanus -pert ... | 2017 | 28301267 |
| risk factors for community-acquired bacterial meningitis. | bacterial meningitis is a significant burden of disease and mortality in all age groups worldwide despite the development of effective conjugated vaccines. the pathogenesis of bacterial meningitis is based on complex and incompletely understood host-pathogen interactions. some of these are pathogen-specific, while some are shared between different bacteria. | 2017 | 28301990 |
| structure-based functional annotation of putative conserved proteins having lyase activity from haemophilus influenzae. | haemophilus influenzae is a small pleomorphic gram-negative bacteria which causes several chronic diseases, including bacteremia, meningitis, cellulitis, epiglottitis, septic arthritis, pneumonia, and empyema. here we extensively analyzed the sequenced genome of h. influenzae strain rd kw20 using protein family databases, protein structure prediction, pathways and genome context methods to assign a precise function to proteins whose functions are unknown. these proteins are termed as hypothetica ... | 2015 | 28324295 |
| in silico study on penicillin derivatives and cephalosporins for upper respiratory tract bacterial pathogens. | upper respiratory tract infection (urti) is an acute infection which involves the upper respiratory tract: nose, sinuses, tonsils and pharynx. urt infections are caused mainly by pathogenic bacteria like streptococcus pneumoniae, haemophilus influenzae and staphylococcus aureus. conventionally, β-lactam antibiotics are used to treat urt infections. penicillin binding proteins (pbps) catalyze the cell wall synthesis in bacteria. β-lactam antibiotics like penicillin, cephalosporins, carbapenems an ... | 2014 | 28324428 |
| structure-based function analysis of putative conserved proteins with isomerase activity from haemophilus influenzae. | haemophilus influenzae, a gram-negative bacterium and a member of the family pasteurellaceae, causes chronic bronchitis, bacteremia, meningitis, etc. the h. influenzae is the first organism whose genome was completely sequenced and annotated. here, we have extensively analyzed the genome of h. influenzae using available proteins structure and function analysis tools. the objective of this analysis is to assign a precise function to hypothetical proteins (hps) whose functions are not determined s ... | 2015 | 28324524 |
| erratum: antibodies from multiple sclerosis patients preferentially recognize hyperglucosylated adhesin of non-typeable haemophilus influenzae. | 2017 | 28327637 | |
| isolation of antimicrobial resistant bacteria in upper respiratory tract infections of patients. | haemophilus influenzae, streptococcus pyogenes, moraxella catarrhalis, staphylococcus aureus, and streptococcus pneumoniae are usual cause of upper respiratory tract infection cases. the present study aims the isolation of bacterial strains which are resistant to the commonly prescribed antibiotics. in total, 900 throat swabs were obtained from the patients suffering from upper respiratory tract infections residing in three different localities. the maximum number of isolates (64 %) were obtaine ... | 2016 | 28330238 |
| analysis of mic and disk diffusion testing variables for gepotidacin and comparator agents against select bacterial pathogens. | this study was conducted to determine the effect of testing parameters on the in vitro activity of gepotidacin, a new triazaacenaphthylene antibacterial agent for the treatment of conventional and biothreat pathogens. clsi methods, and variations of these methods were used to test 10 staphylococcus aureus, 10 streptococcus pneumoniae, 10 haemophilus influenzae, and 5 escherichia coli by mic and 30 s. aureus, 15 s. pneumoniae and 15 s. pyogenes by disk diffusion (dd) methods. levofloxacin and lin ... | 2017 | 28330893 |
| throat swabs in children with respiratory tract infection: associations with clinical presentation and potential targets for point-of-care testing. | diagnostic uncertainty over respiratory tract infections (rtis) in primary care contributes to over-prescribing of antibiotics and drives antibiotic resistance. if symptoms and signs predict respiratory tract microbiology, they could help clinicians target antibiotics to bacterial infection. this study aimed to determine relationships between symptoms and signs in children presenting to primary care and microbes from throat swabs. | 2017 | 28334924 |
| draft genome sequences of three nontypeable strains of haemophilus influenzae, c188, r535, and 1200, isolated from different types of disease. | nontypeable haemophilus influenzae is a persistent human respiratory pathogen known to be involved in a range of acute and chronic respiratory diseases. here, we report the genome sequences of three h. influenzae strains isolated from sputum, otitis media, and blood. comparative analyses revealed significant differences in the gene contents including the presence of genes mediating antibiotic resistance. | 2017 | 28336588 |
| immunogenicity and safety of primary and booster vaccination with 2 investigational formulations of diphtheria, tetanus and haemophilus influenzae type b antigens in a hexavalent dtpa-hbv-ipv/hib combination vaccine in comparison with the licensed infanrix hexa. | safety and immunogenicity of 2 investigational formulations of diphtheria, tetanus and haemophilus influenzae type b antigens of the combined diphtheria-tetanus-acellular pertussis-hepatitis b-inactivated poliomyelitis-hib vaccine (dtpa-hbv-ipv/hib) were evaluated in a primary (nct01248884) and a booster vaccination (nct01453998) study. in the primary study, 721 healthy infants (randomized 1:1:1) received 3 doses of dtpa-hbv-ipv/hib formulation a (datapa-hbv-ipv/hib), or b (dbtbpa-hbv-ipv/hib) o ... | 2017 | 28340322 |
| the role of acute and chronic respiratory colonization and infections in the pathogenesis of copd. | copd is a major global concern, increasingly so in the context of ageing populations. the role of infections in disease pathogenesis and progression is known to be important, yet the mechanisms involved remain to be fully elucidated. while copd pathogens such as haemophilus influenzae, moraxella catarrhalis and streptococcus pneumoniae are strongly associated with acute exacerbations of copd (aecopd), the clinical relevance of these pathogens in stable copd patients remains unclear. immune respo ... | 2017 | 28342288 |
| epidemiological profile and vaccination coverage in splenectomy patients in a health area of murcia (1993-2012). | splenectomy patients have a high risk of suffering severe infections, many of them preventable by vaccination. the aim of the study was to analyse the clinical epidemiological characteristics and vaccine coverage of these patients in health area iii of the region of murcia. | 2017 | 28342711 |
| culture of non-typeable haemophilus influenzae from the nasopharynx: not all media are equal. | the efficacy of chocolate agar, versus bacitracin, vancomycin, clindamycin, chocolate agar (bvcca) for the isolation of non-typeable haemophilus influenzae (nthi) from nasopharyngeal swabs was determined. bvcca cultured nthi from 97.3% of nthi-positive swabs, compared to 87.1% for chocolate agar. to maximise culture sensitivity, the use of both media is recommended. | 2017 | 28342745 |
| 50 years ago in the journal of pediatrics: systemic infection with haemophilus influenzae in very young infants. | 2017 | 28343529 | |
| retrospective report of antimicrobial susceptibility observed in bacterial pathogens isolated from ocular samples at mount sinai hospital, 2010 to 2015. | antimicrobial resistance has emerged as a major threat to global public health. thus, the surveillance of changes in antimicrobial resistance in local and global settings is a paramount necessity. while many studies have tracked antimicrobial resistance, only a small percentage surveyed ocular isolates. the purpose of this study was to report the in vitro susceptibility of bacterial pathogens isolated from ocular samples in new york, ny from 2010 to 2015. | 2017 | 28344783 |
| il-17c mediates the recruitment of tumor-associated neutrophils and lung tumor growth. | chronic obstructive pulmonary disease (copd) is associated with an increased risk for lung cancer and an aberrant microbiota of the lung. microbial colonization contributes to chronic neutrophilic inflammation in copd. nontypeable haemophilus influenzae (nthi) is frequently found in lungs of stable copd patients and is the major pathogen triggering exacerbations. the epithelial cytokine interleukin-17c (il-17c) promotes the recruitment of neutrophils into inflamed tissues. the purpose of this st ... | 2017 | 28346430 |
| bacterial and viral pathogen spectra of acute respiratory infections in under-5 children in hospital settings in dhaka city. | the study aimed to examine for the first time the spectra of viral and bacterial pathogens along with the antibiotic susceptibility of the isolated bacteria in under-5 children with acute respiratory infections (aris) in hospital settings of dhaka, bangladesh. nasal swabs were collected from 200 under-five children hospitalized with clinical signs of aris. nasal swabs from 30 asymptomatic children were also collected. screening of viral pathogens targeted ten respiratory viruses using rt-qpcr. b ... | 2017 | 28346512 |
| haemophilus influenzae type a as a cause of paediatric septic arthritis. | incidence rates of invasive haemophilus influenzae serotype b disease have decreased significantly since the introduction of the hib vaccine; however, the rates in indigenous populations remain disproportionately high, specifically in the paediatric population. additionally, with the decline of type b invasive infections, there has been a rebound in the incidence of invasive infections caused by other strains of h. influenzae, particularly serotype a. | 2016 | 28348786 |
| diagnostic value of bronchoalveolar lavage in children with nonresponding community-acquired pneumonia. | community-acquired pneumonia (cap) is a common cause of morbidity and mortality in hospitalized children. in cap, causative agents are seldom identified using noninvasive diagnostic procedures. for those children not responding to empiric antibiotic therapy, it is vital to identify the causative pathogens for further management. | 2017 | 28351556 |
| haemophilus influenzae pyomyositis in a patient with diabetic ketoacidosis: a unique case and review of literature. | haemophilus influenzae is a gram-negative bacillus commonly known to cause upper respiratory tract infections. skin and soft tissue infections are very uncommon. of these, the majority were associated with necrotizing fasciitis requiring emergent debridement. we report a case of pyomyositis caused by haemophilus influenzae in an adult with diabetes. | 2017 | 28352482 |
| influence of socio-economic inequality measured by the gini coefficient on meningitis incidence caused by mycobacterium tuberculosis and haemophilus influenzae in colombia, 2008-2011. | bacterial meningitis is an important cause of infectious neurological morbidity and mortality. its incidence has decreased with the introduction of vaccination programmes against preventable agents. however, low-income and middle-income countries with poor access to health care still have a significant burden of the disease. thus, the relationship between the gini coefficient and h. influenzae and m. tuberculosis meningitis incidence in colombia, during 2008-2011, was assessed. in this ecologica ... | 2017 | 28353449 |
| molecular characterization and antibiotic susceptibility of haemophilus influenzae clinical isolates. | haemophilus influenzae can cause invasive and severe infections in both adults and children such as otitis media, sinusitis, pneumonia, meningitis and bacteremia. the emerging antibiotic resistance in recent years against ampicillin and several other antibiotics among strains of h. influenzae gives cause for serious concern. here, we investigate ß-lactamase (bl) activity in clinical isolates of h. influenzae, profile their resistance to antibiotics, and characterize the clonal relationship of th ... | 2017 | 28353452 |
| concordance between upper and lower airway microbiota in infants with cystic fibrosis. | nasopharyngeal and oropharyngeal samples are commonly used to direct therapy for lower respiratory tract infections in non-expectorating infants with cystic fibrosis (cf).we aimed to investigate the concordance between the bacterial community compositions of 25 sets of nasopharyngeal, oropharyngeal and bronchoalveolar lavage (bal) samples from 17 infants with cf aged ∼5 months (n=13) and ∼12 months (n=12) using conventional culturing and 16s-rrna sequencing.clustering analyses demonstrated that ... | 2017 | 28356374 |
| bacterial outer membrane vesicle biogenesis: a new mechanism and its implications. | outer membrane vesicle (omv) release by gram-negative bacteria has been observed and studied for decades. first considered as a by-product of cell lysis, it soon became evident that omvs are actively secreted from the outer membrane (om) of gram-negative bacteria. accordingly, these small particles (~ 10-300 nm in diameter) consist mainly of om components like phospholipids (pls), om proteins, and lipopolysaccharides or lipooligosaccharides. however, omvs may also comprise periplasmic, inner mem ... | 2016 | 28357362 |
| next-generation sequencing combined with specific pcr assays to determine the bacterial 16s rrna gene profiles of middle ear fluid collected from children with acute otitis media. | the aim of the study was to analyze the bacteriome of acute otitis media with a novel modification of next-generation sequencing techniques. outpatient children with acute otitis media were enrolled in the study, and middle ear fluids were collected during 90 episodes from 79 subjects aged 5 to 42 months (median age, 19 months). the bacteriome profiles of middle ear fluid samples were determined by a nested-pcr amplification of the 16s rrna gene (v4 region), followed by mass sequencing. the prof ... | 2017 | 28357413 |
| electrostatic repulsion between unique arginine residues is essential for the efficient in vitro assembly of the transmembrane domain of a trimeric autotransporter. | haemophilus influenzae adhesin (hia) belongs to the trimeric autotransporter family and mediates the adherence of these bacteria to the epithelial cells of host organisms. hia contains a passenger and a transmembrane domain. the transmembrane domain forms a 12-stranded β-barrel in which four strands are provided from each subunit. the β-barrel has a pore that is traversed by three α-helices. this domain has a unique arginine cluster, in which the side chains of the three arginine residues locate ... | 2017 | 28357859 |
| acute bilateral photoreceptor degeneration in an infant after vaccination against measles and rubella. | ocular inflammation is occasionally observed after vaccinations, and most of them resolve without permanent visual disturbances. however, there are some rare cases of severe ocular complications following vaccinations. | 2017 | 28358967 |
| first whole-genome sequence of a haemophilus influenzae type e strain isolated from a patient with invasive disease in italy. | in the present era of conjugate vaccines against haemophilus influenzae type b, non-vaccine-preventable strains are of concern. here, we report the first whole-genome sequence of an invasive h. influenzae type e strain. this genomic information will enable further investigations on encapsulated non-type b h. influenzae strains. | 2017 | 28360180 |
| efficacy of 10-valent pneumococcal non-typeable haemophilus influenzae protein d conjugate vaccine against acute otitis media and nasopharyngeal carriage in panamanian children - a randomized controlled trial. | we previously reported 10-valent pneumococcal non-typeable haemophilus influenzae (nthi) protein d conjugate vaccine (phid-cv) efficacy in a double-blind randomized trial (clinicaltrials.gov: nct00466947) against various diseases, including acute otitis media (aom). here, we provide further analyses. in the panamanian subset, 7,359 children were randomized (1:1) to receive phid-cv or control vaccine at age 2/4/6 and 15-18 months. of these, 2,000 had nasopharyngeal swabs collected. aom cases were ... | 2017 | 28368738 |
| emergence of invasive haemophilus influenzae type a disease in italy. | we report on the first detection of two cases of invasive haemophilus influenzae type a (hia) disease in italy. the cases were sustained by the same hia "strain" belonging to the st23 clone that has previously been reported only outside europe. the emergence of invasive hia disease is of concern. | 2017 | 28369218 |
| panel 6: vaccines. | objective to review the literature on progress regarding (1) effectiveness of vaccines for prevention of otitis media (om) and (2) development of vaccine antigens for om bacterial and viral pathogens. data sources pubmed database of the national library of science. review methods we performed literature searches in pubmed for om pathogens and candidate vaccine antigens, and we restricted the searches to articles in english that were published between july 2011 and june 2015. panel members review ... | 2017 | 28372533 |
| influence of the co-administration of heptavalent conjugate vaccine pcv7-tt on the immunological response elicited by va-mengoc-bc® and heberpenta®-l in rabbits. | finlay vaccine institute is developing a new heptavalent conjugate vaccine against streptococcus pneumoniae. as infants are the target population, pcv7-tt will be necessarily co-administered with other vaccines, and then, the interactions represent a concern. the aim of this work is to evaluate the possible immunological interferences in rabbits as animal experimental model. rabbits were immunized with heberpenta®-l, va-mengoc-bc®, and pcv7-tt. blood samples were taken fourteen days after final ... | 2017 | 28379053 |
| specific polysaccharide antibody deficiency revealed by severe bacterial infections in adulthood: a report on eleven cases. | we report on 11 cases of specific polysaccharide antibody deficiency (spad) revealed in adulthood by severe infections with encapsulated bacteria. given that immunoglobulin replacement therapy can effectively prevent the recurrence of bacterial infections in this context, spad should be considered once other antibody deficiencies have been ruled out. | 2017 | 28379361 |
| voluntarily reported immunization registry data: reliability and feasibility to predict immunization rates, san diego, california, 2013. | accurate data on immunization coverage levels are essential to public health program planning. reliability of coverage estimates derived from immunization information systems (iiss) in states where immunization reporting by medical providers is not mandated by the state may be compromised by low rates of participation. to overcome this problem, data on coverage rates are often acquired through random-digit-dial telephone surveys, which require substantial time and resources. this project tested ... | 2017 | 28379785 |
| changes in the conjunctival bacterial flora of patients hospitalized in an intensive care unit. | to identify the changes in aerobic conjunctival bacterial flora and to correlate culture results with physical health and the duration of patients' hospitalization in an intensive care unit (icu). | 2017 | 28380097 |
| transcutaneous immunization with a bandaid prevents experimental otitis media in a polymicrobial model. | otitis media (om) is a common pediatric disease and nontypeable haemophilus influenzae (nthi) is the predominant pathogen in chronic om, recurrent om and om associated with treatment failure. om is also a polymicrobial disease, wherein an upper respiratory tract viral infection predisposes to ascension of nthi from the nasopharynx, the site of colonization, to the normally sterile middle ear, resulting in disease. using a clinically relevant viral-bacterial co-infection model of nthi-induced om, ... | 2017 | 28381402 |
| a thermostabilized, one-step pcr assay for simultaneous detection of klebsiella pneumoniae and haemophilus influenzae. | klebsiella pneumoniae and haemophilus influenzae are two common pathogens associated with respiratory tract infections. the identification of these pathogens using conventional molecular diagnostic tests requires trained personnel, cold-chain transportation, and storage-dependance, which does not render them user-friendly. the aim of this study was to develop a thermostabilized, cold-chain-free, one-step multiplex pcr for simultaneous detection of k. pneumoniae and h. influenzae. the multiplex p ... | 2017 | 28386286 |
| sex bias in diagnostic delay in bronchiectasis: an analysis of the spanish historical registry of bronchiectasis. | diagnostic delay is common in most respiratory diseases, particularly in bronchiectasis. however, sex bias in diagnostic delay has not been studied to date. | 2017 | 28393532 |
| ceftaroline activity tested against bacterial isolates causing community-acquired respiratory tract infections and skin and skin structure infections in pediatric patients from united states hospitals: 2012-2014. | ceftaroline fosamil has recently received us food and drug administration approval for treatment of acute bacterial skin/skin structure infections (sssis), including those caused by methicillin-resistant staphylococcus aureus and community-acquired bacterial pneumonia for pediatric patients ≥2 months old. we evaluated the potency and spectrum of ceftaroline and comparators when tested against community-acquired respiratory tract infection (carti) and sssi pathogens from pediatric patients. a tot ... | 2017 | 28403050 |
| immunogenicity and safety of 10-valent pneumococcal nontypeable haemophilus influenzae protein d conjugate vaccine (phid-cv) administered to children with sickle cell disease between 8 weeks and 2 years of age: a phase iii, open, controlled study. | immunogenicity, safety and reactogenicity of the 10-valent pneumococcal nontypeable haemophilus influenzae protein d conjugate vaccine (phid-cv) were evaluated in children with sickle cell disease (scd), who are at increased risk for infections. | 2017 | 28403055 |
| parasitic infections in pregnancy decrease placental transfer of antipneumococcus antibodies. | many factors can influence maternal placental antibody transfer to the fetus, which confers important immune protection to the newborn infant. however, little is known about the effect of maternal parasitic infection on placental antibody transfer. to investigate this, we selected from a parent study of 576 pregnant kenyan women four groups of women with term deliveries (≥37 weeks), including uninfected women (n = 30) and women with solo infections with malaria (n = 30), hookworm (n = 30), or sc ... | 2017 | 28404574 |
| evaluation of a taqman array card for detection of central nervous system infections. | infections of the central nervous system (cns) are often acute, with significant morbidity and mortality. routine diagnosis of such infections is limited in developing countries and requires modern equipment in advanced laboratories that may be unavailable to a number of patients in sub-saharan africa. we developed a taqman array card (tac) that detects multiple pathogens simultaneously from cerebrospinal fluid. the 21-pathogen cns multiple-pathogen tac (cns-tac) assay includes two parasites (ba ... | 2017 | 28404679 |
| emergence and molecular characterization of haemophilus influenzae harbouring mef(a)-authors' response. | 2017 | 28407066 |