Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| lipopolysaccharide-induced inflammation of bronchi and emphysematous changes of pulmonary parenchyma in miniature pigs (sus scrofa domestica). | lipopolysaccharide (lps) is widely used to induce chronic obstructive pulmonary disease (copd) in animal models. rodents are most commonly used to model copd, but their substantial anatomic and physiological differences from humans present a challenge in the research of copd pathogenesis. the authors induced copd in miniature pigs by intratracheal administration of lps solution. they carried out bronchoalveolar lavage (bal) and collected the fluid for analyses of white blood cells, cytokines and ... | 2013 | 23423297 |
| molecular identification of nematode larvae different from those of the trichinella genus detected by muscle digestion. | although larvae of the genus trichinella are the most common parasite species detected in vertebrate muscles using artificial digestion, nematode larvae belonging to other genera are sometimes detected and incorrectly identified as trichinella. however, it is often very difficult to identify these larvae at the species, genus or family level using microscopy because of the absence of specific morphological characters or cuticle damage, and the only means of identification is pcr and sequencing o ... | 2013 | 23433986 |
| bone response to biomimetic implants delivering bmp-2 and vegf: an immunohistochemical study. | this animal study evaluated bone healing around titanium implant surfaces biomimetically coated with bone morphogenic protein-2 (bmp-2) and/or vascular endothelial growth factor (vegf) by examining bone matrix proteins and mineralisation. five different implant surfaces were established: acid-etched surface (ae), biomimetic calcium phosphate surface (cap), bmp-2 loaded cap surface, vegf loaded cap surface and dual bmp-2 + vegf loaded cap surface. the implants were inserted into calvariae of adul ... | 2013 | 23434516 |
| high prevalence of torque teno sus virus in china and genetic diversity of the 5' non-coding region. | members of the family anelloviridae are emerging circular dna viruses infecting many species of vertebrates including pigs. to date, members of two distinct genera, iotatorquevirus, including torque teno sus virus 1a and torque teno sus virus 1b (ttsuv1a and ttsuv1b), and kappatorquevirus, including torque teno sus virus k2a and torque teno sus virus k2b (ttsuvk2a and ttsuvk2b), have been identified in domestic pigs and wild boars. the goal of this study was to evaluate the prevalence and geneti ... | 2013 | 23435953 |
| initial in vivo experience with a novel type of mr-safe pushable coils for mr-guided embolizations. | conventional detachable embolization coils are made from platinum or stainless steel and may thus be a magnetic resonance (mr) safety hazard because of resonant device heating. the objective of this experimental study was to assess the feasibility of mr-guided embolization procedures with a novel type of nonmetallic and, therefore, intrinsically mr-safe pushable coil. | 2013 | 23442773 |
| compressive rib fracture: peri-mortem and post-mortem trauma patterns in a pig model. | despite numerous studies on high impact fractures of ribs, little is known about compressive rib injuries. we studied rib fractures from a biomechanical and morphological perspective using 15, 5th ribs of domestic pigs sus scrofa, divided into two groups, desiccated (representing post-mortem trauma) and fresh ribs with intact periosteum (representing peri-mortem trauma). ribs were axially compressed and subjected to four-point bending in an instron 3339 fitted with custom jigs. morphoscopic anal ... | 2013 | 23453778 |
| trichinella infections in different host species of an endemic district of serbia. | trichinella infections are endemic in the balkan region of europe. though trichinellosis and agents thereof are serious problems for human health and animal husbandry, only a limited number of trichinella isolates from serbia have been identified at the species level so far. the aim of the present study was the surveillance and monitoring of trichinella in domestic pigs and wild animals from the endemic district of branicevo. investigations performed during the 2009-2010 period revealed trichine ... | 2013 | 23453823 |
| in vivo and in situ evaluation of a wireless magnetoelastic sensor array for plastic biliary stent monitoring. | this paper presents the in vivo and in situ evaluation of a system that wirelessly monitors the accumulation of biliary sludge in a plastic biliary stent. the sensing element, located within the stent, is a passive array of magnetoelastic resonators that is queried by a wireless electromagnetic signal. the in vivo and in situ testing uses commercially-available plastic biliary stents, each enhanced with an array of ribbon sensors (formed from metglas™ 2826 mb). the sensor array is approximately ... | 2013 | 23460136 |
| a high throughput genotyping approach reveals distinctive autosomal genetic signatures for european and near eastern wild boar. | the lack of a near eastern genetic signature in modern european porcine breeds indicates that, although domestic pigs from the fertile crescent entered europe during the neolithic, they were completely replaced by their european counterparts in a short window of time. whilst the absence of such genetic signature has been convincingly demonstrated at the mitochondrial level, variation at the autosomal genomes of european and near eastern sus scrofa has not been compared yet. herewith, we have exp ... | 2013 | 23460788 |
| evaluation of the risk of classical swine fever (csf) spread from backyard pigs to other domestic pigs by using the spatial stochastic disease spread model be-fast: the example of bulgaria. | the study presented here is one of the very first aimed at exploring the potential spread of classical swine fever (csf) from backyard pigs to other domestic pigs. specifically, we used a spatial stochastic spread model, called be-fast, to evaluate the potential spread of csf virus (csfv) in bulgaria, which holds a large number of backyards (96% of the total number of pig farms) and is one of the very few countries for which backyard pigs and farm counts are available. the model revealed that, d ... | 2013 | 23465838 |
| determination of coenzyme q10 tissue status via high-performance liquid chromatography with electrochemical detection in swine tissues (sus scrofa domestica). | swine tissues were used as surrogates for human tissues with coenzyme q10 (coq10) as the primary endogenous quinoid to establish a reliable method for the analysis of total coq10 concentration and redox status using the reduced and oxidized forms of coq9 as internal standards. specimens of frozen swine tissues were disrupted by bead milling using 2-propanol as the homogenization medium supplemented with the internal standards. after hexane extraction, coq10 was analyzed via high-performance liqu ... | 2013 | 23467099 |
| molecular detection and genomic characterization of torque teno sus virus 1 and 2 from domestic pigs in central china. | in the present study, torque teno sus viruses (ttsuvs) were detected in tissue and blood samples obtained from domestic pigs in central china, and complete genomes of ttsuvs were characterized. a total of three tissue samples (3/20, 15 %) from post-weaning multisystemic wasting syndrome-affected pigs and 30 blood samples (30/40, 75 %) from healthy pigs were positive for torque teno sus virus 1 (ttsuv1) and/or 2 (ttsuv2). two ttsuv strains (ttv1hn54 and ttv2hn93) comprising 2,794 and 2,875 nucleo ... | 2013 | 23468229 |
| range of blood lactate values in farm pigs prior to experimental surgery. | in biomedical research the pig is widely used as an animal model for experimental surgery. feasible monitoring tools during anaesthesia are pivotal for successful and reliable research outcome. blood lactate values are a monitoring tool and prognostic indicator during surgery both in humans and animals. lactate levels in pigs might be influenced by various parameters including stressful handling, breed and weight differences. to determine blood lactate levels present prior to experimental surger ... | 2013 | 23479774 |
| [study on hepatocyte apoptosis of domestic pigs experimentally infected with taenia asiatica and taenia saginata]. | to investigate apoptosis in liver tissue of the domestic pigs infected with eggs of taenia asiatica and taenia saginata. | 2012 | 23484276 |
| laparoscopic partial nephrectomy using a flexible co2 laser fiber. | laparoscopic partial nephrectomy (lpn) is a challenging surgery that requires precise tissue cutting and meticulous hemostasis under warm ischemia conditions. in this study, we tested the feasibility of performing lpn using co2 laser energy transmitted through a specialized flexible mirror optical fiber. | 2012 | 23484569 |
| detection of rickettsia parkeri from within piura, peru, and the first reported presence of candidatus rickettsia andeanae in the tick rhipicephalus sanguineus. | domestic farm animals (n=145) were sampled for the presence of ectoparasites in northwestern peru during march, 2008. ninety domestic animals (62%) were positive for the presence of an ectoparasite(s) and produced a total collection of the following: 728 ticks [amblyomma maculatum, anocentor nitens, rhipicephalus (boophilus) microplus, rhipicephalus sanguineus, and otobius megnini], 12 lice (haematopinus suis), and 3 fleas (ctenocephalides felis). a rickettsia genus-specific qpcr assay was perfo ... | 2013 | 23488453 |
| make the most of your samples: bayes factor estimators for high-dimensional models of sequence evolution. | accurate model comparison requires extensive computation times, especially for parameter-rich models of sequence evolution. in the bayesian framework, model selection is typically performed through the evaluation of a bayes factor, the ratio of two marginal likelihoods (one for each model). recently introduced techniques to estimate (log) marginal likelihoods, such as path sampling and stepping-stone sampling, offer increased accuracy over the traditional harmonic mean estimator at an increased ... | 2013 | 23497171 |
| the spatial ecology of free-ranging domestic pigs (sus scrofa) in western kenya. | in many parts of the developing world, pigs are kept under low-input systems where they roam freely to scavenge food. these systems allow poor farmers the opportunity to enter into livestock keeping without large capital investments. this, combined with a growing demand for pork, especially in urban areas, has led to an increase in the number of small-holder farmers keeping free range pigs as a commercial enterprise. despite the benefits which pig production can bring to a household, keeping pig ... | 2013 | 23497587 |
| the phylogenetic status of typical chinese native pigs: analyzed by asian and european pig mitochondrial genome sequences. | china is one of the most diverse countries, which have developed 88 indigenous pig breeds. several studies showed that pigs were independently domesticated in multiple regions of the world. the purpose of this study was to investigate the origin and evolution of chinese pigs using complete mitochondrial genomic sequences (mtdna) from asian and european domestic pigs and wild boars. thirty primer pairs were designed to determine the mtdna sequences of xiang pig, large white, lantang, jinhua and p ... | 2013 | 23497624 |
| are juvenile domestic pigs (sus scrofa domestica) sensitive to the attentive states of humans?--the impact of impulsivity on choice behaviour. | previous studies have shown that apes, dogs and horses seem to be able to attribute attentive states to humans. subjects had to choose between two persons: one who was able to see the animal and one who was not. using a similar paradigm, we tested a species that does not rely strongly on visual cues, the domestic pig (sus scrofa domestica). subjects could choose between two unfamiliar persons, with only one showing attention, in three different conditions (body, head away, body turned - head fro ... | 2013 | 23500190 |
| meat from wild boar (sus scrofa l.): a review. | wild boar is a species that is utilised for food and sport hunting throughout the world. recent increases in natural populations and the potential of farming wild boars have stimulated interest in this species as a meat producer. compared to domestic pigs, wild boars present a higher degree of carcass fatness and larger loin areas, more slow-twitch oxidative (i) and fast-twitch oxidative glycolytic (iia) and less fast-twitch glycolytic (iib) muscle fibres, and darker, less tender and leaner meat ... | 2013 | 23501250 |
| effects of pretreatment hypothermia during resuscitated porcine hemorrhagic shock. | accidental hypothermia increases mortality and morbidity after hemorrhage, but controversial data are available on the effects of therapeutic hypothermia. therefore, we tested the hypothesis whether moderate pretreatment hypothermia would beneficially influence organ dysfunction during long-term, porcine hemorrhage and resuscitation. | 2013 | 23507715 |
| fatal infection due to haemophilus parasuis in a young wild boar (sus scrofa). | haemophilus parasuis is a recognized pathogen in domestic pigs; the pathogen has been also isolated from healthy wild boar (sus scrofa). in the current report, a case of fatal h. parasuis infection in a wild boar piglet from central spain is described. the affected animal presented severe pneumonic lesions, inflammation in tarsal joints with presence of fibrinous deposits, and epidural hemorrhage in the atlanto-occipital joint. pure growth of h. parasuis was obtained from lungs and tarsal joints ... | 2013 | 23512924 |
| too fresh is unattractive! the attraction of newly emerged nicrophorus vespilloides females to odour bouquets of large cadavers at various stages of decomposition. | the necrophagous burying beetle nicrophorus vespilloides reproduces on small carcasses that are buried underground to serve as food for their offspring. cadavers that are too large to bury have previously been postulated to be important food sources for newly emerged beetles; however, the attractiveness of distinct successive stages of decomposition were not further specified. therefore, we investigated the potential preference of newly emerged n. vespilloides females for odour bouquets of pigle ... | 2013 | 23516497 |
| phasic contractions in urinary bladder from juvenile versus adult pigs. | alterations in properties of the bladder with maturation are relevant physiologically and pathophysiologically. the aim of this study was to investigate alterations in bladder properties with maturation in juvenile vs. adult pig, focussing on differences between layers of the bladder wall (mucosa vs. detrusor) and the presence and functional contribution of interstitial cells (ics). | 2013 | 23516515 |
| pig lumbar spine anatomy and imaging-guided lateral lumbar puncture: a new large animal model for intrathecal drug delivery. | intrathecal (it) administration is an important route of drug delivery, and its modelling in a large animal species is of critical value. although domestic swine is the preferred species for preclinical pharmacology, no minimally invasive method has been established to deliver agents into the it space. while a "blind" lumbar puncture (lp) can sample cerebrospinal fluid (csf), it is unreliable for drug delivery in pigs. using computed tomography (ct), we determined the underlying anatomical reaso ... | 2013 | 23518340 |
| classical swine fever in the pygmy hog. | the pygmy hog is a rare, small and highly endangered mammal belonging to the suidae family, and it is presently found only in the assam state of india. while investigating the cause of death of pygmy hogs housed at a conservation centre for captive breeding and research at basistha, assam, it was confirmed that they were susceptible to and died as a result of contracting classical swine fever (csf), caused by csf virus (csfv), which is a highly infectious endemic disease of domestic pigs in indi ... | 2012 | 23520745 |
| review: influenza virus in pigs. | influenza virus disease still remains one of the major threats to human health, involving a wide range of animal species and pigs play an important role in influenza ecology. pigs were labeled as "mixing vessels" since they are susceptible to infection with avian, human and swine influenza viruses and genetic reassortment between these viruses can occur. after the h1n1 influenza pandemic of 2009 with a swine origin virus, the most recent research in "influenzology" is directed at improving knowl ... | 2013 | 23523121 |
| hepatitis e virus seroprevalence of domestic pigs in germany determined by a novel in-house and two reference elisas. | autochthonous hepatitis e virus (hev) infections by zoonotic transmission of genotype 3 (gt3) have been reported increasingly from industrialized countries. in this paper the development and validation of an igg elisa for the detection of hev-specific antibodies in domestic pigs is described. comparison of the diagnostic value of escherichia coli-expressed hev-gt3 capsid protein (cp) derivatives revealed a carboxy-terminal derivative as most suitable. validation of the in-house assay using a com ... | 2013 | 23523888 |
| successive and conditional discrimination learning in pigs. | we studied the ability of pigs to discriminate tone cues using successive and conditional discrimination tasks. pigs (n = 8) were trained in a successive discrimination go/no-go task (experiment 1) to associate a go-cue with a reward at the end of a runway and a no-go-cue with the absence of reward. latency to reach the goal-box was recorded for each cue-type. learning of a conditional discrimination task was compared between low-birthweight (lbw, n = 5) and normal-birthweight (nbw, n = 6) pigs ... | 2013 | 23525688 |
| spectrophotometric retinal oximetry in pigs. | to assess the validity of spectrophotometric retinal oximetry by comparison to blood gas analysis and intravitreal measurements of partial pressure of oxygen (po(2)). | 2013 | 23532527 |
| cranial nerve threshold for thermal injury induced by mri-guided high-intensity focused ultrasound (mrghifu): preliminary results on an optic nerve model. | future clinical applications of magnetic resonance imaging-guided high-intensity focused ultrasound (mrghifu) are moving toward the management of different intracranial pathologies. we sought to validate the production, safety, and efficacy of thermal injury to cranial nerves generated by mrghifu. in this study, five female domestic pigs underwent a standard bifrontal craniectomy under general anesthesia. treatment was then given using an mrghifu system to induce hyperthermic ablative sonication ... | 2013 | 23549530 |
| pandemic influenza a viruses escape from restriction by human mxa through adaptive mutations in the nucleoprotein. | the interferon-induced dynamin-like mxa gtpase restricts the replication of influenza a viruses. we identified adaptive mutations in the nucleoprotein (np) of pandemic strains a/brevig mission/1/1918 (1918) and a/hamburg/4/2009 (ph1n1) that confer mxa resistance. these resistance-associated amino acids in np differ between the two strains but form a similar discrete surface-exposed cluster in the body domain of np, indicating that mxa resistance evolved independently. the 1918 cluster was conser ... | 2013 | 23555271 |
| novel insights into the genetic diversity of balantidium and balantidium-like cyst-forming ciliates. | balantidiasis is considered a neglected zoonotic disease with pigs serving as reservoir hosts. however, balantidium coli has been recorded in many other mammalian species, including primates. here, we evaluated the genetic diversity of b. coli in non-human primates using two gene markers (ssrdna and its1-5.8sdna-its2). we analyzed 49 isolates of ciliates from fecal samples originating from 11 species of captive and wild primates, domestic pigs and wild boar. the phylogenetic trees were computed ... | 2013 | 23556024 |
| prevalence of porcine hokovirus and its co-infection with porcine circovirus 2 in china. | here, we report the frequency of porcine hokovirus (phov) infection and its co-infection with porcine circovirus 2 (pcv2) in china. a total of 485 domestic pig samples were tested for both phov and pcv2, and ns1 gene sequences from 11 phov strains were used for phylogenetic analysis. the prevalence of phov and pcv2 was 51.3 % and 36.3 %, respectively, and co-infection occurred in 20.2 %. phovs from the chinese mainland showed a close relationship to those isolated in hong kong. co-infection with ... | 2013 | 23558802 |
| effects of mobilization regimens in donors on outcomes of hematopoietic cell transplantation in miniature swine. | toxicities and complications associated with hematopoietic cell transplantation currently limit this potentially curative therapy for malignant and nonmalignant blood disorders. miniature swine provide a clinically relevant model for studies to improve posttransplantation outcomes. miniature swine recipients of high-dose haploidentical hepatopoietic cell transplantation after reduced-intensity conditioning consisting of low-dose (100 cgy) total-body irradiation, partial t-cell depletion by using ... | 0 | 23561882 |
| clean technique for prolonged nonsurvival cardiothoracic surgery in swine (sus scrofa). | laboratory animal regulations provide little guidance regarding duration of nonsurvival surgery requiring aseptic technique. we hypothesized that swine would experience no sepsis during nonsurvival cardiothoracic surgery accomplished by using clean technique and lasting 8 h or less. incision sites of 5 male farm pigs (sus scrofa) were shaved and then cleaned with alcohol and povidone-iodine. the surgeon wore sterile gloves, clean scrubs, and hair bonnet; assistants wore clean scrubs and nonsteri ... | 2013 | 23562035 |
| multi frequency phase fluorimetry (mfpf) for oxygen partial pressure measurement: ex vivo validation by polarographic clark-type electrode. | measurement of partial pressure of oxygen (po2) at high temporal resolution remains a technological challenge. this study introduces a novel po2 sensing technology based on multi-frequency phase fluorimetry (mfpf). the aim was to validate mfpf against polarographic clark-type electrode (cte) po2 measurements. | 2013 | 23565259 |
| highly porous hydroxyapatite with and without local harvested bone in sinus floor augmentation: a histometric study in pigs. | sinus floor augmentation with autologous bone is an accepted treatment option in dental implantology. in this study, an entirely synthetic, nano-structured, hydroxyapatite-based bone substitute material (sbsm, nanobone(®); artoss, rostock, germany) was supplemented with a mixture of locally harvested bone to enhance osteogenesis. | 2014 | 23566297 |
| experimental infection of european starlings (sturnus vulgaris) and house sparrows (passer domesticus) with pandemic 2009 h1n1 and swine h1n1 and h3n2 triple reassortant influenza viruses. | european starlings (sturnus vulgaris) and house sparrows (passer domesticus) are common peridomestic passerine birds that are often associated with domestic animal production facilities. this association provides a potential means for pathogen transmission between facilities. we inoculated european starlings and house sparrows with three non-avian influenza virus strains: two swine isolates (h1n1 and h3n2) and one human isolate representing the h1n1 pandemic strain that originated from swine. no ... | 2013 | 23568924 |
| feasibility of endoscopic transumbilical thoracic sympathectomy in a porcine model. | thoracoscopic sympathectomy is an effective treatment for palmar hyperhidrosis. current methods are associated with risks of chronic neuropathic pain and a visible chest scar. we developed a novel surgical technique for the performance of sympathectomy by embryonic natural orifice transumbilical endoscopic surgery with a flexible endoscope in a porcine model. | 2013 | 23579034 |
| antegrade side branch access in branched aortic arch endografts: a porcine feasibility study. | to describe the deployment technique for a single side branch arch endograft in a porcine model and prove the concept of transseptal or transapical antegrade access for catheterization and introduction of the mating stent-graft. | 2013 | 23581770 |
| focused ultrasound to expel calculi from the kidney: safety and efficacy of a clinical prototype device. | focused ultrasound has the potential to expel small stones or residual stone fragments from the kidney, or move obstructing stones to a nonobstructing location. we evaluated the efficacy and safety of ultrasonic propulsion in a live porcine model. | 2013 | 23583535 |
| soybean yield and heterodera glycines responses to liquid swine manure in nematode suppressive soil and conducive soil. | the soybean cyst nematode (scn), heterodera glycines, is a major factor limiting soybean yield. experiments were conducted in 2009 and 2010 to determine the effects of liquid swine manure and chemical fertilizer pk on soybean and corn yields, and on scn population in an scn-suppressive field (s-site) and an scn-conducive field (c-site) in minnesota. the experiment was a split-plot design with crop sequences as main plots and fertilizer treatments as subplots. the 2-yr crop sequences were sus-sus ... | 0 | 23589656 |
| a lumen sizing workhorse guidewire for peripheral vasculature: two functions in one device. | ideally, guidewires used during peripheral vasculature (pv) interventions could serve both as a therapy delivery platform and a diagnostic tool for real-time vessel sizing (2-in-1 function). | 2014 | 23592431 |
| phylogenetic analyses of novel squamate adenovirus sequences in wild-caught anolis lizards. | adenovirus infection has emerged as a serious threat to the health of captive snakes and lizards (i.e., squamates), but we know relatively little about this virus' range of possible hosts, pathogenicity, modes of transmission, and sources from nature. we report the first case of adenovirus infection in the iguanidae, a diverse family of lizards that is widely-studied and popular in captivity. we report adenovirus infections from two closely-related species of anolis lizards (anoles) that were re ... | 2013 | 23593364 |
| hepatitis e: a puzzling double-faced disease. | viral hepatitis type e is highly endemic in many developing countries, where large water-borne epidemics caused by viral genotype 1 and - to a lesser degree - by genotype 2 cyclically occur, resulting in high morbidity and mortality, especially among pregnant women. in developed countries, the disease is usually diagnosed in travelers coming back from endemic countries, but an increasing number of sporadic locally acquired hepatitis cases caused by genotype 3 and 4 have recently been reported. t ... | 2013 | 23598800 |
| complete genome sequences of classical swine fever virus strains isolated from wild boars in south korea. | classical swine fever is a disease that is devastating the pig industry worldwide. here, we report the complete genome sequences of two classical swine virus strains (yc11wb and pc11wb), isolated from korean wild boars in 2011. both strains belong to subgenotype 2.1b. the complete genome sequences of pc11wb and yc11wb are more similar to that of strain zj0801 (isolated in china) than to that of the sw03 strain isolated from domestic pigs in south korea. | 2013 | 23599291 |
| cytochrome b based genetic differentiation of indian wild pig (sus scrofa cristatus) and domestic pig (sus scrofa domestica) and its use in wildlife forensics. | the indian wild pig (sus scrofa cristatus) is a protected species and listed in the indian wildlife (protection) act, 1972. the wild pig is often hunted illegally and sold in market as meat warranting punishment under law. to avoid confusion in identification of these two subspecies during wildlife forensic examinations, we describe genetic differentiation of indian wild and domestic pigs using a molecular technique. analysis of sequence generated from the partial fragment (421bp) of mitochondri ... | 2012 | 23601732 |
| activation of indoleamine 2,3-dioxygenase by lps in a porcine model. | indoleamine 2,3-dioxygenase (ido) is a rate-limiting enzyme for the degradation of tryptophan (trp) along the kynurenine (kyn) pathway, and its increased activation is associated with immunologic disorders. because the specific role of ido activation is not yet completely clear, the aim of the present study was to establish a pig model of ido activation for further research. the activation of ido in pigs was induced experimentally by lps stimulation in vivo and ex vivo. ido activation was charac ... | 2014 | 23606516 |
| protective effects of ranolazine and propranolol, alone or combined, on the structural and functional alterations of cardiomyocyte mitochondria in a pig model of ischemia/reperfusion. | preventing the consequences of ischemia/reperfusion (i/r)-induced lesions in the clinic requires the administration of pharmacological agents prior to restoring coronary vascularization. the aim of this study was to evaluate the effects of ranolazine and propranolol when administered either alone or combined prior to i/r induction in a pig model. thirty domestic pigs were randomly assigned to five groups of six animals including (i) sham animals; (ii) untreated animals with 45-min ischemia and 1 ... | 2014 | 23607936 |
| angiotensin receptor blockade has protective effects on the poststenotic porcine kidney. | angiotensin-converting enzyme inhibitors/angiotensin ii receptor blockers (arbs) may induce an acute decrease of glomerular filtration rate (gfr) in the stenotic kidney in renal artery stenosis, but most patients tolerate these drugs well. we hypothesized that angiotensin-converting enzyme inhibitors/arbs stabilize stenotic kidney function during prolonged treatment by conferring protective effects. we tested this in control domestic pigs and pigs with renal artery stenosis untreated or treated ... | 2013 | 23615504 |
| primary proteasome inhibition results in cardiac dysfunction. | the proteasome prevents the intracellular accumulation of proteins and its impairment can lead to structural and functional alterations, as noted for the coronary vasculature in a previous study. utilizing the same model, this study was designed to test the hypothesis that chronic proteasome inhibition (psi) also leads to structural and functional changes of the heart. | 2013 | 23616520 |
| constitutive expression of cyp3a mrna in bama miniature pig tissues. | the pig, particularly the miniature pig (minipig), is becoming an important animal model due to its physiological and anatomical similarities to humans. bama minipigs (sus scrofa domestica), a chinese natural minipig breed, are a promising animal model. the pig is a useful model for drug metabolism and pharmacological studies due to the similar properties of cytochrome p450 (cyp)3a between pigs and humans. however, a detailed investigation regarding the abundance and expression of cyp3a in porci ... | 2013 | 23618816 |
| serological and molecular investigation of the prevalence of aujeszky's disease in feral swine (sus scrofa) in the subregions of the pantanal wetland, brazil. | the feral swine (fs) originated from the domestic pig and is present throughout the brazilian wetland plain (the pantanal). aujeszky's disease (ad) was first serologically confirmed in the state of mato grosso do sul (ms) in 2001; however, there was no viral confirmation. the aim of this study was to investigate antibodies against-suhv-1 in the sera of feral swine in the studied areas, detect suhv-1 through pcr and classify the viral genome. among the 218 animals sampled, 186 were analyzed by el ... | 2013 | 23639473 |
| [effect of ulinastatin on improving inflammatory response and myocardial and lung tissue injury after cardiopulmonary resuscitation in pigs]. | to evaluate the effects of ulinastatin (uti) on improving inflammatory response and myocardial and lung tissue injury after cardiopulmonary resuscitation (cpr) in porcine model. | 2013 | 23648163 |
| porcine e. coli: virulence-associated genes, resistance genes and adhesion and probiotic activity tested by a new screening method. | we established an automated screening method to characterize adhesion of escherichia coli to intestinal porcine epithelial cells (ipec-j2) and their probiotic activity against infection by enteropathogenic e. coli (epec). 104 intestinal e. coli isolates from domestic pigs were tested by pcr for the occurrence of virulence-associated genes, genes coding for resistances to antimicrobial agents and metals, and for phylogenetic origin by pcr. adhesion rates and probiotic activity were examined for c ... | 2013 | 23658605 |
| administration of amiodarone during resuscitation is associated with higher tumor necrosis factor-α levels in the early postarrest period in the swine model of ischemic ventricular fibrillation. | to compare the early postarrest inflammatory cytokine response between animals administered amiodarone (amio) and lidocaine (lido) intra-arrest during resuscitation from ventricular fibrillation (vf). domestic swine (n=32) were placed under general anesthesia and instrumented before spontaneous vf was induced by balloon occlusion of the left anterior descending coronary artery. after 7 min of vf, standard acls resuscitation was performed and animals were randomized to either bolus amio (5 mg/kg, ... | 2013 | 23659671 |
| immunogenicity and safety of a natural rough mutant of brucella suis as a vaccine for swine. | the objective of the current study was to evaluate the safety, immunogenicity and clearance of the natural rough mutant of brucella suis strain 353-1 (353-1) as a vaccine in domestic swine. in three studies encompassing 105 animals, pigs were inoculated with 353-1 by conjunctival (5 × 10(7) cfu) or im (1-2 × 10(10) cfu) routes. clearance, tissue distribution, and pathology of the vaccine strain were determined by periodic blood culture, collection of tissues at periodic necropsy times after vacc ... | 2013 | 23659743 |
| cloning changes the response to obesity of innate immune factors in blood, liver, and adipose tissues in domestic pigs. | the objective of this study was to evaluate the usefulness of cloned pigs as porcine obesity models reflecting obesity-associated changes in innate immune factor gene expression profiles. liver and adipose tissue expression of 43 innate immune genes as well as serum concentrations of six immune factors were analyzed in lean and diet-induced obese cloned domestic pigs and compared to normal domestic pigs (obese and lean). the number of genes affected by obesity was lower in cloned animals than in ... | 2013 | 23668862 |
| structural and functional annotation of the porcine immunome. | the domestic pig is known as an excellent model for human immunology and the two species share many pathogens. susceptibility to infectious disease is one of the major constraints on swine performance, yet the structure and function of genes comprising the pig immunome are not well-characterized. the completion of the pig genome provides the opportunity to annotate the pig immunome, and compare and contrast pig and human immune systems. | 2013 | 23676093 |
| crushed rephased orthogonal slice selection (cross) for simultaneous acquisition of two orthogonal proton resonance frequency temperature maps. | to evaluate a novel imaging sequence termed crushed rephased orthogonal slice selection (cross) that uses the available time in long echo time (te) gradient echo (gre) imaging-as employed for proton resonance frequency (prf) shift thermometry-to simultaneously acquire two orthogonal magnetic resonance imaging (mri) temperature maps around the target region. | 2013 | 23677906 |
| us-guided application of nd:yag laser in porcine pancreatic tissue: an ex vivo study and numerical simulation. | laser ablation (la) with a neodymium-doped yttrium aluminum garnet (nd:yag) laser is a minimally invasive approach able to achieve a high rate of complete tissue necrosis. in a previous study we described the feasibility of eus-guided nd:yag pancreas la performed in vivo in a porcine model. | 2013 | 23680175 |
| effects of cognitive enrichment on behavioural and physiological reactions of pigs. | cognitive enrichment, a special form of environmental enrichment, addresses the cognitive abilities of animals in captivity. through cognitive interaction with the environment, the animals regain a certain control over their environment, and essential resources, such as food or water, act as a reward for successful coping. it is assumed that this process has important implications for animal welfare, especially in the intensive housing systems of farm animals. this study investigates the effects ... | 2013 | 23680428 |
| a novel non-vascular system to treat resistant hypertension. | to evaluate in a preclinical model the utility of a monopolar electrode catheter delivering radiofrequency (rf) energy placed into the renal pelvis in order to treat resistant hypertension (rh). | 2013 | 23685301 |
| disposition and excretion of 14c-ahtn (7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene) and 14c-hhcb (1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-cyclopenta-gamma-2-benzopyran) after intravenous administration to sprague-dawley rats and domestic pigs. | 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene (ahtn ) and 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-gamma-2-benzopyran (hhcb) are polycyclic musks widely used as fragrance ingredients in consumer products. because their metabolic fate following systemic exposure is not fully characterized, disposition and excretion of (14)c-ahtn- and (14)c-hhcb-derived radioactivity were studied in sprague-dawley rats and domestic pigs following a single intravenous dose. rats admini ... | 2013 | 23685777 |
| reintroductions and genetic introgression from domestic pigs have shaped the genetic population structure of northwest european wild boar. | population genetic studies focus on natural dispersal and isolation by landscape barriers as the main drivers of genetic population structure. however, anthropogenic factors such as reintroductions, translocations and wild x domestic hybridization may also have strong effects on genetic population structure. in this study we genotyped 351 single nucleotide polymorphism markers evenly spread across the genome in 645 wild boar (sus scrofa) from northwest europe to evaluate determinants of genetic ... | 2013 | 23688182 |
| mild therapeutic hypothermia is superior to controlled normothermia for the maintenance of blood pressure and cerebral oxygenation, prevention of organ damage and suppression of oxidative stress after cardiac arrest in a porcine model. | mild therapeutic hypothermia (ht) has been implemented in the management of post cardiac arrest (ca) syndrome after the publication of clinical trials comparing ht with common practice (ie, usually hyperthermia). current evidence on the comparison between therapeutic ht and controlled normothermia (nt) in ca survivors, however, remains insufficient. | 2013 | 23688243 |
| classical swine fever. | classical swine fever is a serious and economically important transboundary disease threatening pig production globally. the infection may occur in backyard pigs, feral pig populations and domestic pigs. whereas there are proven control strategies for the latter pig population, control in backyard pigs with poor biosecurity settings or in wild boar populations of high density still poses a problem in some parts of the world. laboratory diagnostic methods, efficacious vaccines and contingency pla ... | 2013 | 23689894 |
| local hemodynamic disturbance accelerates early thrombosis of small-caliber expanded polytetrafluoroethylene grafts. | small-caliber expanded polytetrafluoroethylene (eptfe) grafts cannot be used widely in the clinical situation because of early thrombosis and occlusion. this unsolved and under-recognized problem warrants further investigation. | 2013 | 23703290 |
| experimental evaluation of pharmacokinetic profile and biological effect of a novel paclitaxel microcrystalline balloon coating in the iliofemoral territory of swine. | new paclitaxel coated balloons (pcb) developments have been proposed to maintain therapeutic levels of drug in the tissue while decreasing particle release. in this series of studies, we evaluated the pharmacokinetic profile and biological effects after paclitaxel delivery via novel microcrystalline pcb coating (mcpcb, pax®, balton) in porcine iliofemoral arteries. | 2014 | 23703720 |
| molecular investigation of torque teno sus virus in geographically distinct porcine breeding herds of sichuan, china. | torque teno sus virus (ttsuv), infecting domestic swine and wild boar, is a non-enveloped virus with a circular, single-stranded dna genome. which has been classified into the genera iotatorquevirus (ttsuv1) and kappatorquevirus (ttsuv2) of the family anelloviridae. a molecular study was conducted to detect evidence of a phylogenic relationship between these two porcine ttsuv genogroups from the sera of 244 infected pigs located in 21 subordinate prefectures and/or cities of sichuan. | 2013 | 23705989 |
| features of hepatitis e virus infection in humans and animals in japan. | in japan, hepatitis e had long been considered to be a rare liver disease which can be accidentally imported from endemic countries in asia and africa, where the sanitation conditions are suboptimal. however, since the identification of the first autochthonous hepatitis e case and hepatitis e viremic domestic pigs in japan in 2001, our understanding of hepatitis e virus (hev) infection in this country has been changing markedly. this has largely been due to the development of serological and gen ... | 2014 | 23721425 |
| comparative genomics of salmonella enterica serovars derby and mbandaka, two prevalent serovars associated with different livestock species in the uk. | despite the frequent isolation of salmonella enterica sub. enterica serovars derby and mbandaka from livestock in the uk and usa little is known about the biological processes maintaining their prevalence. statistics for salmonella isolations from livestock production in the uk show that s. derby is most commonly associated with pigs and turkeys and s. mbandaka with cattle and chickens. here we compare the first sequenced genomes of s. derby and s. mbandaka as a basis for further analysis of the ... | 2013 | 23725633 |
| deletion of virulence associated genes from attenuated african swine fever virus isolate our t88/3 decreases its ability to protect against challenge with virulent virus. | african swine fever virus (asfv) causes an acute haemorrhagic disease of domestic pigs against which there is no effective vaccine. the attenuated asfv strain our t88/3 has been shown previously to protect vaccinated pigs against challenge with some virulent strains including our t88/1. two genes, dp71l and dp96r were deleted from the our t88/3 genome to create recombinant virus our t88/3δdp2. deletion of these genes from virulent viruses has previously been shown to reduce asfv virulence in dom ... | 2013 | 23725691 |
| insulin affects sperm capacity in pig through nitric oxide. | insulin (ins) has recently been demonstrated to have the ability to induce the capacitation process in pig spermatozoa. in various mammalian species, capacitation has been linked to the nitric oxide (no) signalling; therefore, this study investigated no production in ins-treated pig spermatozoa by fluorescence-activated cell sorting. for the same samples, sperm capacitation was evaluated by chlortetracycline staining, protein tyrosine phosphorylation pattern and acrosomal status. a significant i ... | 2013 | 23728590 |
| digestive physiology of the pig symposium: intestinal bile acid sensing is linked to key endocrine and metabolic signaling pathways. | bile acids have historically been considered to mainly function in cholesterol homeostasis and facilitate fat digestion in the gastrointestinal tract. recent discoveries show that bile acids also function as signaling molecules that exert diverse endocrine and metabolic actions by activating g protein-coupled bile acid receptor 1 (gpbar1/g-protein-coupled bile acid receptor 1 or tgr5), a membrane g protein-coupled receptor, and farnesoid x receptor (fxr), a member of the nuclear hormone receptor ... | 2013 | 23729782 |
| working and reference memory of pigs (sus scrofa domesticus) in a holeboard spatial discrimination task: the influence of environmental enrichment. | interest in cognitive research in pigs is increasing, but little is known about the impact of environmental conditions on pigs' cognitive capabilities. the present study investigated the effect of environmental enrichment on cognitive performance of pigs in a holeboard spatial task, in which they had to discriminate four baited buckets out of 16. pigs (n = 32) were either housed in stimulus-poor, barren pens, or in larger pens enriched with rooting substrates. pigs were subjected to 30 holeboard ... | 2013 | 23740471 |
| hepatitis e virus genotype 3 strains in domestic pigs, cameroon. | 2013 | 23751099 | |
| performance characteristics of qpcr assays targeting human- and ruminant-associated bacteroidetes for microbial source tracking across sixteen countries on six continents. | numerous quantitative pcr assays for microbial fecal source tracking (mst) have been developed and evaluated in recent years. widespread application has been hindered by a lack of knowledge regarding the geographical stability and hence applicability of such methods beyond the regional level. this study assessed the performance of five previously reported quantitative pcr assays targeting human-, cattle-, or ruminant-associated bacteroidetes populations on 280 human and animal fecal samples from ... | 2013 | 23755882 |
| the effect of weather conditions on burnt bone fragmentation. | this research assesses how weather conditions, such as temperature and rainfall, affect the fragmentation of burnt bone. the recovery of human remains from fatal fire scenes is often hampered by the fragmentary nature of the material, and through understanding how weather factors affect this fragmentation, it may be possible to adjust recovery timelines and protocols to maximise the quantity and quality of condition of the material recovered. these data are also valuable as a baseline for expect ... | 2013 | 23756520 |
| [occurrence and geographical distribution of antibodies to hepatitis e virus in wild boars of saxony-anhalt, germany (2011)]. | hepatitis e virus (hev) may cause acute hepatitis in humans. in industrialised countries, acute hepatitis e generally occurs only sporadically. however, in recent years an increase in the number of reported cases has been observed. concerning autochthonous, non-travel-associated cases, a zoonotic transmission, particularly from the animal reservoirs of domestic pig and wild boar, and via undercooked meat is assumed. meanwhile, hev has been detected in domestic pig holdings as well as in wild boa ... | 2013 | 23758038 |
| squamous cell carcinoma in an aged german landrace sow (sus scrofa domestica). | skin tumors are rarely observed in pigs, and, in particular, only a few cases of squamous cell carcinoma have been reported. the present case report describes the occurrence of a squamous cell carcinoma located in the skin at the center of the udder of a 14-year-old german landrace sow. the tumor was spherical and 17.0 cm in diameter. the tissue of the distal pole had a cauliflowerlike appearance, was black and ulcerated with a malodorous exudation. the sow did not show any signs of reduced gene ... | 2013 | 23758043 |
| transgenic pig expressing the red fluorescent protein kusabira-orange as a novel tool for preclinical studies on hepatocyte transplantation. | research on hepatocyte transplantation as an alternative or supplementary treatment for liver transplantation is progressing. however, to advance to clinical trials, confidence in the technique must be established and its safety must be validated by conducting experiments using animals of comparable sizes to humans, such as pigs. we used transgenic pigs expressing red fluorescence protein for investigating the distribution and survival of transplanted cells. | 2013 | 23769049 |
| systemic cd14 inhibition attenuates organ inflammation in porcine escherichia coli sepsis. | sepsis is an infection-induced systemic inflammatory response syndrome. upstream recognition molecules, like cd14, play key roles in the pathogenesis. the aim of the present study was to investigate the effect of systemic cd14 inhibition on local inflammatory responses in organs from septic pigs. pigs (n = 34) receiving escherichia coli-bacteria or e. coli-lipopolysaccharide (lps) were treated with an anti-cd14 monoclonal antibody or an isotype-matched control. lungs, liver, spleen, and kidneys ... | 2013 | 23774598 |
| pseudorabies in feral swine in the united states, 2009-2012. | although pseudorabies virus can affect a wide range of mammalian and avian hosts, swine are the only natural hosts of the virus. the us commercial swine industry obtained pseudorabies-free status in 2004, which was important because of the economic value of domestic swine production; however, feral swine remain competent hosts and represent a constant threat for reintroducing the virus into the commercial industry. to better assess feral swine infection status, we collected 8,498 serum samples f ... | 2013 | 23778627 |
| substantial variation in the extent of mitochondrial genome fragmentation among blood-sucking lice of mammals. | blood-sucking lice of humans have extensively fragmented mitochondrial (mt) genomes. human head louse and body louse have their 37 mt genes on 20 minichromosomes. in human pubic louse, the 34 mt genes known are on 14 minichromosomes. to understand the process of mt genome fragmentation in the blood-sucking lice of mammals, we sequenced the mt genomes of the domestic pig louse, haematopinus suis, and the wild pig louse, h. apri, which diverged from human lice approximately 65 ma. the 37 mt genes ... | 0 | 23781098 |
| biological significance of urolithins, the gut microbial ellagic acid-derived metabolites: the evidence so far. | the health benefits attributed to pomegranate have been associated with its high content in polyphenols, particularly ellagitannins. this is also the case for other ellagitannin-containing fruits and nuts including strawberry, raspberry, blackberry, walnuts, and muscadine grapes. the bioavailability of ellagitannins and ellagic acid is however very low. these molecules suffer extensive metabolism by the gut microbiota to produce urolithins that are much better absorbed. urolithins circulate in p ... | 2013 | 23781257 |
| torque teno sus virus (ttsuv) in tissues of pigs and its relation with the occurrence of postweaning multisystemic wasting syndrome. | torque teno sus virus (ttsuv) is a member of the recently created family anelloviridae. two distinct species of ttsuvs, 1 (ttsuv1) and 2 (ttsuv2) have been reported so far in domestic pigs and wild boars. although ttsuvs have not been clearly linked to any specific disease of pigs, a relation between ttsuv infections and postweaning multisystemic wasting syndrome (pmws) has been suggested. to examine further this possibility, the present study was conducted in search for ttsuv1 and ttsuv2 genome ... | 2013 | 23783757 |
| effects of chest compressions on cardiorespiratory function in a non-arrested porcine model. | the effects of chest compressions to hemodynamic and respiratory parameters during hands-only cardiopulmonary resuscitation (cpr) in a non-arrested patient who suddenly collapses are confusing. in this research, we investigated the effects of chest compressions in a non-arrested porcine model. | 2013 | 23786952 |
| non-radiological method for three-dimensional implant position evaluation using an intraoral scan method. | this technical innovation presents a method that reproduces the position of a dental implant after insertion without the reuse of x-ray radiation. | 2014 | 23799977 |
| a new species of rhipicephalus (acari: ixodidae), a parasite of red river hogs and domestic pigs in the democratic republic of congo. | a new tick species belonging to the genus rhipicephalus koch, 1844 (acari: ixodidae), namely, rhipicephalus congolensis n. sp., is described. males and females of this species are similar to those of rhipicephalus complanatus neumann, 1911 and rhipicephalus planus neumann, 1907, but it can be distinguished from them by a pattern of dense medium-sized punctations on the conscutum and scutum. males of r. congolensis may be distinguished by the following characters: posterior half of the marginal g ... | 2013 | 23802441 |
| 3d organization of telomeres in porcine neutrophils and analysis of lps-activation effect. | while the essential role of 3d nuclear architecture on nuclear functions has been demonstrated for various cell types, information available for neutrophils, essential components of the immune system, remains limited. in this study, we analysed the spatial arrangements of telomeres which play a central role in cell fate. our studies were carried out in swine, which is an excellent model organism for both biomedical research and agronomic applications. we isolated bacterial artificial chromosome ... | 2013 | 23803152 |
| diversity of picornaviruses in rural bolivia. | the family picornaviridae is a large and diverse group of viruses that infect humans and animals. picornaviruses are among the most common infections of humans and cause a wide spectrum of acute human disease. this study began as an investigation of acute flaccid paralysis (afp) in a small area of eastern bolivia, where surveillance had identified a persistently high afp rate in children. stools were collected and diagnostic studies ruled out poliovirus. we tested stool specimens from 51 afp cas ... | 2013 | 23804569 |
| high-dose erythropoietin during cardiac resuscitation lessens postresuscitation myocardial stunning in swine. | we investigated the metabolic and functional myocardial effects of erythropoietin (epo) administered during resuscitation from cardiac arrest using an open-chest pig model of ventricular fibrillation and resuscitation by extracorporeal circulation, after having reported in rats a reversal of postresuscitation myocardial dysfunction associated with activation of mitochondrial protective pathways. ventricular fibrillation was induced in 16 male domestic pigs and left untreated for 8 minutes, after ... | 2013 | 23806450 |
| histopathologic validation of optical coherence tomography findings of non-apposed side-branch struts in porcine arteries. | the presence of uncovered struts overlying side branch is considered to be a potential risk of stent thrombosis. the accuracy in detection of neointimal strut coverage at branch point by optical coherence tomography (oct) has not been validated in comparison with histology. | 2013 | 23813068 |
| seasonal variation of carcass decomposition and gravesoil chemistry in a cold (dfa) climate. | it is well known that temperature significantly affects corpse decomposition. yet relatively few taphonomy studies investigate the effects of seasonality on decomposition. here, we propose the use of the köppen-geiger climate classification system and describe the decomposition of swine (sus scrofa domesticus) carcasses during the summer and winter near lincoln, nebraska, usa. decomposition was scored, and gravesoil chemistry (total carbon, total nitrogen, ninhydrin-reactive nitrogen, ammonium, ... | 2013 | 23822087 |
| evolutionary dynamics of copy number variation in pig genomes in the context of adaptation and domestication. | copy number variable regions (cnvrs) can result in drastic phenotypic differences and may therefore be subject to selection during domestication. studying copy number variation in relation to domestication is highly relevant in pigs because of their very rich natural and domestication history that resulted in many different phenotypes. to investigate the evolutionary dynamic of cnvrs, we applied read depth method on next generation sequence data from 16 individuals, comprising wild boars and dom ... | 2013 | 23829399 |
| adenosine receptor expression in an experimental animal model of myocardial infarction with preserved left ventricular ejection fraction. | adenosine, a purine nucleoside and a "retaliatory metabolite" in ischemia, is ubiquitous in the body and increases 100-fold during ischemia. its biological actions are mediated by four adenosine receptors (ars): a(1), a(2a), a(2b) and a(3). the aim of this study was to determine possible myocardial alterations in ar expression in an experimental animal model of myocardial infarction (mi) with a preserved left ventricular (lv) ejection fraction. lv tissue was collected from sexually mature male f ... | 2014 | 23843027 |
| how immunogenetically different are domestic pigs from wild boars: a perspective from single-nucleotide polymorphisms of 19 immunity-related candidate genes. | the coexistence of wild boars and domestic pigs across eurasia makes it feasible to conduct comparative genetic or genomic analyses for addressing how genetically different a domestic species is from its wild ancestor. to test whether there are differences in patterns of genetic variability between wild and domestic pigs at immunity-related genes and to detect outlier loci putatively under selection that may underlie differences in immune responses, here we analyzed 54 single-nucleotide polymorp ... | 2013 | 23846851 |