Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| lymphoproliferative disorders with concurrent hhv8 and ebv infection: beyond primary effusion lymphoma and germinotropic lymphoproliferative disorder. | lymphoproliferative disorders (lpd) characterised by human herpesvirus 8 (hhv8) and epstein-barr virus (ebv) infection are rare and two entities are included in the world health organisation classification: primary effusion lymphoma (pel) and germinotropic lpd. these two entities have very different clinicopathological presentations and prognosis. here we describe two cases of hhv8-positive, ebv-positive lymphoma with clinicopathological features that are not consistent with either pel or germin ... | 2017 | 29105119 |
| epstein-barr virus brlf1 induces genomic instability and progressive malignancy in nasopharyngeal carcinoma cells. | nasopharyngeal carcinoma (npc) is a serious health problem in china and southeast asia. relapse is the major cause of mortality, but mechanisms of relapse are mysterious. epstein-barr virus (ebv) reactivation and host genomic instability (gi) have correlated with npc development. previously, we reported that lytic early genes dnase and balf3 induce genetic alterations and progressive malignancy in npc cells, implying lytic proteins may be required for npc relapse. in this study, we show that imm ... | 2017 | 29108278 |
| cancer therapy-associated lymphoproliferative disorders: an under-recognized type of immunodeficiency-associated lymphoproliferative disorder. | we describe the clinicopathologic features of 17 patients who had a hematologic malignancy of various types, were treated, and subsequently developed a lymphoproliferative disorder (lpd). there were 10 men and 7 women with a median age of 59 years (range, 36 to 83 y). the primary hematologic neoplasms included: 5 chronic lymphocytic leukemia/small lymphocytic lymphoma, 3 plasma cell myeloma, 2 acute monoblastic leukemia, and 1 case each of mixed-phenotype acute leukemia, chronic myeloid leukemia ... | 2018 | 29112013 |
| b lymphoblastic leukemia/lymphoma with burkitt-like morphology and igh/myc rearrangement: report of 3 cases in adult patients. | isolated myc rearrangement without other recurrent genetic abnormalities is rare in b lymphoblastic leukemia/lymphoma (b-all/lbl), with most cases reported in pediatric patients. we report 3 adult cases with lymphoblasts showing a precursor b cell immunophenotype, and isolated myc/igh translocation. all 3 cases occurred in male patients with initial presentation of diffuse lymphadenopathy. cases 1 and 2 had b-all with significantly increased lymphoblasts in peripheral blood and bone marrow. case ... | 2018 | 29112016 |
| toll-like receptor 9 polymorphism is associated with increased epstein-barr virus and cytomegalovirus acquisition in hiv-exposed infants. | : polymorphisms in the toll-like receptor 9 1635 locus have been associated with hiv-1 acquisition and progression. cytomegalovirus (cmv) and epstein-barr virus (ebv) acquisition were compared between kenyan hiv-exposed infants by 1635 genotype. having one or more copies of the 1635a allele was associated with increased cmv acquisition in hiv-infected infants (42 vs. 11%, p = 0.03) and increased risk of ebv acquisition in hiv-exposed uninfected infants (hazard ratio = 4.2, p = 0.02) compared wit ... | 2018 | 29112074 |
| diabetes and risk of kaposi's sarcoma: effects of high glucose on reactivation and infection of kaposi's sarcoma-associated herpesvirus. | patients with diabetes are generally prone to pathogen infection and tumor progression. here, we investigated the potential association between diabetes and kaposi's sarcoma (ks), a tumor linked to infection with kaposi's sarcoma-associated herpesvirus (kshv). by using taiwan's national health insurance research database, we found that diabetes is statistically associated with increased risk of ks in a case-control study. since a high level of blood sugar is the hallmark of diabetes, we determin ... | 2017 | 29113328 |
| risk factors for post-transplant lymphoproliferative disorder after thymoglobulin-conditioned hematopoietic cell transplantation. | epstein-barr virus (ebv)-induced post-transplant lymphoproliferative disorder (ptld) occurs frequently when rabbit antithymocyte globulin (atg) is used in hematopoietic cell transplant (hct) conditioning. we retrospectively studied 554 patients undergoing atg-conditioned myeloablative hct. strategies used to minimize mortality due to ptld were either therapy of biopsy-diagnosed ptld in the absence of ebv dnaemia monitoring (n = 266) or prompt therapy of presumed ptld (based on clinical/radiologi ... | 2018 | 29114932 |
| identification of epstein-barr virus in the human placenta and its pathologic characteristics. | epstein-barr virus (ebv), a common pathogen in humans, is suspected as the cause of multiple pregnancy-related pathologies including depression, preeclampsia, and stillbirth. moreover, transmission of ebv through the placenta has been reported. however, the focus of ebv infection within the placenta has remained unknown to date. in this study, we proved the expression of latent ebv genes in the endometrial glandular epithelial cells of the placenta and investigated the cytological characteristic ... | 2017 | 29115077 |
| prognostic value of plasma epstein-barr virus dna level during posttreatment follow-up in the patients with nasopharyngeal carcinoma having undergone intensity-modulated radiotherapy. | the value of epstein-barr virus (ebv) dna assay during posttreatment follow-up of the patients with nasopharyngeal carcinoma (npc) presenting with different pretreatment plasma ebv dna levels remains unclear. in the present study, we aimed to evaluate the prognostic value of plasma ebv dna assay during posttreatment follow-up in the patients with npc who have undergone intensity-modulated radiotherapy. | 2017 | 29116021 |
| the regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers. | activation of specific sets of protein kinases by intracellular signal molecules has become more and more apparent in the past decade. phosphorylation, one of key posttranslational modification events, is activated by kinase or regulatory protein and is vital for controlling many physiological functions of eukaryotic cells such as cell proliferation, differentiation, malignant transformation, and signal transduction mediated by external stimuli. moreovers, the reversible modification of phosphor ... | 2017 | 29116588 |
| elevated expression of ebv and tlrs in the brain is associated with rasmussen's encephalitis. | rasmussen's encephalitis (re) is a rare pediatric neurological disorder, the etiology of which remains unclear. it has been speculated that the immunopathogenesis of re involves damage to neurons, which eventually leads to the occurrence of re. viral infection may be a critical factor in triggering re immunopathogenesis. in this study, we analyzed the expression of epstein-barr virus (ebv) antigens as well as of toll-like receptor 3 (tlr3), tlr9, and downstream adapter tirdomain-containing adapt ... | 2017 | 29116594 |
| c-myc represses transcription of epstein-barr virus latent membrane protein 1 early after primary b cell infection. | recent evidence has shown that the epstein-barr virus (ebv) oncogene lmp1 is not expressed at high levels early after ebv infection of primary b cells, despite its being essential for the long-term outgrowth of immortalized lymphoblastoid cell lines (lcls). in this study, we found that expression of lmp1 increased 50-fold between 7 days postinfection and the lcl state. metabolic labeling of nascent transcribed mrna indicated that this was primarily a transcription-mediated event. ebna2, the key ... | 2018 | 29118124 |
| pediatric pulmonary epstein-barr virus-positive diffuse large b-cell lymphoma: a case report and review of the literature. | non-hodgkin's lymphoma (nhl) is a common malignancy of childhood; however, a lung primary presentation is an uncommon finding, as is finding an association with the epstein-barr virus (ebv). we report the case of a 23-month-old female who developed ebv-associated diffuse large b-cell lymphoma (dlbcl) that was initially thought to be pneumonia. extensive tissue necrosis, focal angioinvasion, and angiodestruction were observed. she was refractory to various therapy regimens, subsequently developed ... | 2017 | 29119031 |
| computer-aided design of an epitope-based vaccine against epstein-barr virus. | epstein-barr virus is a very common human virus that infects 90% of human adults. ebv replicates in epithelial and b cells and causes infectious mononucleosis. ebv infection is also linked to various cancers, including burkitt's lymphoma and nasopharyngeal carcinomas, and autoimmune diseases such as multiple sclerosis. currently, there are no effective drugs or vaccines to treat or prevent ebv infection. herein, we applied a computer-aided strategy to design a prophylactic epitope vaccine ensemb ... | 2017 | 29119120 |
| humanised mouse models for haematopoiesis and infectious diseases. | "humanised" mouse models have emerged over past years as powerful tools for investigating human haematopoiesis and immunity. they allowed the identification of key factors for the maintenance and function of normal and leukaemic human haematopoietic stem cells. these findings have been widely used to dissect the pathogenesis of multiple myeloid and lymphoid neoplasms, such as acute myeloid leukaemia and acute lymphoblastic leukaemia. furthermore, these models can serve as a stepping-stone to cli ... | 2017 | 29120027 |
| epstein-barr virus infection in multiple sclerosis patients. | multiple sclerosis (ms) is the most common inflammatory autoimmune cns disease, with unknown etiology. we aimed to determine the coexistence of ms with antibodies to epstein-barr virus and its gene sequences (ebna1 and bhrf1). the study included 60 ms patients and 60 control subjects. serum samples were processed by elisa for detection of ebv antibodies, and latent ebv genes were determined by real time pcr in blood samples. while 18 (30%) ms cases had anti- ebv igm antibodies, all controls were ... | 2017 | 29120577 |
| programmed death-1 ligands pd-l1 and pd-l2 show distinctive and restricted patterns of expression in lymphoma subtypes. | the success of immunotherapy using immune checkpoint blockade in solid tumors and in relapsed/refractory classical hodgkin lymphoma and chronic lymphocytic leukemia holds promise for targeted therapy in hematologic malignancies. because efficacy of immunomodulatory therapy is correlated with numbers of cells that express programmed death (pd-1) ligands, we evaluated the expression of pd-l1 and pd-l2 proteins using immunohistochemistry in more than 702 diagnostic lymphoma biopsies. in classical h ... | 2018 | 29122656 |
| genetic predictors of response to systemic therapy in esophagogastric cancer. | the incidence of esophagogastric cancer is rapidly rising, but only a minority of patients derive durable benefit from current therapies. chemotherapy as well as anti-her2 and pd-1 antibodies are standard treatments. to identify predictive biomarkers of drug sensitivity and mechanisms of resistance, we implemented prospective tumor sequencing of patients with metastatic esophagogastric cancer. there was no association between homologous recombination deficiency defects and response to platinum-b ... | 2018 | 29122777 |
| metagenomic deep sequencing of aqueous fluid detects intraocular lymphomas. | currently, the detection of pathogens or mutations associated with intraocular lymphomas heavily relies on prespecified, directed pcrs. with metagenomic deep sequencing (mds), an unbiased high-throughput sequencing approach, all pathogens as well as all mutations present in the host's genome can be detected in the same small amount of ocular fluid. | 2018 | 29122821 |
| encephalitis treatment - a case report with long-term follow-up of ebv pcr in cerebrospinal fluid. | epstein-barr virus (ebv) has been found to cause infectious mononucleosis multiple times, but has been associated rarely with ebv encephalitis. also, whenever it is diagnosed, it is always treated symptomatically. | 2017 | 29123419 |
| assessment of the combined effect of epstein-barr virus and plasmodium falciparum infections on endemic burkitt lymphoma using a multiplex serological approach. | epstein-barr virus (ebv) is a necessary cause of endemic burkitt lymphoma (ebl), while the role of plasmodium falciparum in ebl remains uncertain. this study aimed to generate new hypotheses on the interplay between both infections in the development of ebl by investigating the igg and igm profiles against several ebv and p. falciparum antigens. serum samples collected in a childhood study in malawi (2005-2006) from 442 hiv-seronegative children (271 ebl cases and 171 controls) between 1.4 and 1 ... | 2017 | 29123514 |
| gastric carcinomas with lymphoid stroma: categorization and comparison with solid-type colonic carcinomas. | to determine whether histologic features could help identify gastric carcinomas with lymphoid stroma associated with microsatellite instability (msi) (ie, "medullary carcinomas"), epstein-barr virus (ebv) infection (termed lymphoepithelioma-like carcinomas in other organ systems), or neither. | 2017 | 29126141 |
| posttransplant lymphoproliferative disorder in solid organ and hematopoietic stem cell transplantation. | posttransplant lymphoproliferative disorders (ptld) represent an immunosuppression-related lymphoid or plasmacytic proliferation that occur in the setting of solid organ transplant or allogeneic hematopoietic stem cell transplantation (hsct). ptld is a devastating consequence of hsct and solid organ transplantation with a high morbidity and mortality. most commonly, ptld is related to epstein-barr virus (ebv) infection, but an increasing number of non-ebv-related cases are occurring. initial the ... | 2017 | 29128025 |
| a dramatic case of odynophagia. | we report the case of a 77-year-old male with a history of aortic stenosis and interstitial lung disease, who debuted 3 years ago with an outbreak of necrotic and very painful canker sores. the severity of the lesions and their refractory response to treatment led to several hospital admissions and multiple consultations to different specialists (ent, rheumatology, dermatology, ophthalmology, cardiology, and internal medicine). during this time, the patient received central parenteral nutrition ... | 2017 | 29128948 |
| interferon-γ-inducible protein 16 (ifi16) is required for the maintenance of epstein-barr virus latency. | epstein-barr virus (ebv) exhibits both lytic and latent (lat. i, ii, and iii) phases in an infected individual. it's during the latent phase of ebv that all ebv-associated cancers, including burkitt's lymphoma, nasopharyngeal carcinoma and lymphoproliferative disease arise. interferon-γ-inducible protein 16 (ifi16) is a well-established innate immune sensor and viral transcriptional regulator involved in response to invading dna viruses. during latency, ifi16 remains in the nucleus, in part boun ... | 2017 | 29132393 |
| latent membrane protein 1 is a novel determinant of epstein-barr virus genome persistence and reactivation. | epstein-barr virus (ebv) is a ubiquitous gammaherpesvirus that persistently infects humans, with nearly 95% seropositivity in adults. infection in differentiating epithelia is permissive, but ebv-associated nasopharyngeal carcinoma (npc) tumors harbor a clonal and nonproductive latent infection. however, in explanted npc cultures and epithelial cell lines, episomal ebv genomes are frequently lost. the resulting unstable infection has hampered efforts to study the determinants of ebv persistence ... | 2017 | 29134204 |
| unsuspected lymphomatoid granulomatosis in a patient with antisynthetase syndrome. | clinical diagnosis of lymphomatoid granulomatosis (lyg) often is difficult, especially in patients with multiple comorbidities. we present a 60-year-old woman with worsening fatigue, night sweats, unintentional weight loss, and dyspnea of 2 weeks' duration. her medical history was remarkable for recent radiation therapy for recurrent breast cancer and antisynthetase syndrome complicated by interstitial lung disease and controlled with azathioprine. computed tomography showed ground-glass opaciti ... | 2017 | 29136066 |
| [the prognostic significance of plasma epstein-barr virus dna in patients with diffuse large b cell lymphoma]. | to retrospectively analyze the prognostic significance of plasma epstein-barr virus (ebv) dna in 122 patients with diffuse large b cell lymphoma (dlbcl). plasma ebv dna positivity was related to advanced disease stage (p=0.030), b symptoms (p=0.004) and elevated serum lactic dehydrogenase (ldh) (p=0.001). furthermore, univariate analysis indicated that plasma ebv dna level was associated with worse overall survival (os) (hr=0.223, 95%ci 0.096-0.518, p<0.001) and worse progression free survival ( ... | 2017 | 29136714 |
| ebv and apoptosis: the viral master regulator of cell fate? | epstein-barr virus (ebv) was first discovered in cells from a patient with burkitt lymphoma (bl), and is now known to be a contributory factor in 1-2% of all cancers, for which there are as yet, no ebv-targeted therapies available. like other herpesviruses, ebv adopts a persistent latent infection in vivo and only rarely reactivates into replicative lytic cycle. although latency is associated with restricted patterns of gene expression, genes are never expressed in isolation; always in groups. h ... | 2017 | 29137176 |
| programmed death ligand-1 and met co-expression is a poor prognostic factor in gastric cancers after resection. | programmed death-ligand 1 (pd-l1) plays an essential protein for immune evasion, contributing to tumor development and progression. recent studies have reported met as an upregulator for pd-l1 overexpression through an oncogenic pathway. however, an association between pd-l1 expression with met has not been reported in gastric cancer.the prognostic significance of pd-l1 and its association with epstein-barr virus (ebv), microsatellite instability (msi), and mucin phenotype remain controversial. ... | 2017 | 29137273 |
| correction for ansari et al., "constitutive interferon-inducible protein 16-inflammasome activation during epstein-barr virus latency i, ii, and iii in b and epithelial cells". | 2017 | 29138330 | |
| epstein-barr virus-positive mucocutaneous ulcer in a patient with polycythemia vera treated with oral hydroxyurea. | 2017 | 29139148 | |
| epstein-barr virus protein eb2 stimulates translation initiation of mrnas through direct interactions with both poly(a)-binding protein and eukaryotic initiation factor 4g. | epstein-barr virus (ebv) expresses several mrnas produced from intronless genes that could potentially be unfavorably translated compared to cellular spliced mrnas. to overcome this situation, the virus encodes an rna-binding protein (rbp) called eb2, which was previously found to both facilitate the export of nuclear mrnas and increase their translational yield. here, we show that eb2 binds both nuclear and cytoplasmic cap-binding complexes (cbc and eukaryotic initiation factor 4f [eif4f], resp ... | 2018 | 29142127 |
| the epstein-barr virus episome maneuvers between nuclear chromatin compartments during reactivation. | the human genome is structurally organized in three-dimensional space to facilitate functional partitioning of transcription. we learned that the latent episome of the human epstein-barr virus (ebv) preferentially associates with gene-poor chromosomes and avoids gene-rich chromosomes. kaposi's sarcoma-associated herpesvirus behaves similarly, but human papillomavirus does not. contacts localize on the ebv side to orip, the latent origin of replication. this genetic element, and the ebna1 protein ... | 2017 | 29142137 |
| clinical and pathological characterization of epstein-barr virus-associated gastric carcinomas in portugal. | to determine the prevalence of epstein-barr virus (ebv)-associated gastric carcinomas in the north region of portugal and to study its clinicopathological characteristics. | 2017 | 29142476 |
| correction to: abstracts : 29th european congress of pathology. | in poster sessions, the first-author name was missing from the authorship group originally listed for abstract ps-13-001 (page s176), entitled "gastric carcinoma with lymphoid stroma: analysis of microsatellite instability and epstein-barr virus status". the correct authorship group is shown above. | 2017 | 29143111 |
| association of dna repair genes polymorphisms and mutations with increased risk of head and neck cancer: a review. | dna repair mechanisms allow maintain genomic stability and proper functioning within the cells. any aberrations may cause an increased risk of many diseases such as cancer. the most crucial risk factors for head and neck squamous cell carcinoma are behavioral factors, predominantly chronic exposure to tobacco, alcohol addiction, and infection with human papillomavirus or epstein-barr virus. these agents can induce dna damage; therefore, cells must activate appropriate mechanisms in order to func ... | 2017 | 29143133 |
| oncogenic spiral by infectious pathogens: cooperation of multiple factors in cancer development. | chronic infection is one of the major causes of cancer, and there are several mechanisms for infection-mediated oncogenesis. some pathogens encode gene products that behave like oncogenic factors, hijacking cellular pathways to promote the survival and proliferation of infected cells in vivo. some of these viral oncoproteins trigger a cellular damage defense response leading to senescence; however, other viral factors hinder this suppressive effect, suggesting that cooperation of those viral fac ... | 2018 | 29143406 |
| epstein-barr virus hijacks dna damage response transducers to orchestrate its life cycle. | the epstein-barr virus (ebv) is a ubiquitous virus that infects most of the human population. ebv infection is associated with multiple human cancers, including burkitt's lymphoma, hodgkin's lymphoma, a subset of gastric carcinomas, and almost all undifferentiated non-keratinizing nasopharyngeal carcinoma. intensive research has shown that ebv triggers a dna damage response (ddr) during primary infection and lytic reactivation. the ebv-encoded viral proteins have been implicated in deregulating ... | 2017 | 29144413 |
| target-induced proximity ligation triggers recombinase polymerase amplification and transcription-mediated amplification to detect tumor-derived exosomes in nasopharyngeal carcinoma with high sensitivity. | tumor-derived exosomes (texs) are extracellular vesicles that are continuously released into the blood by tumor cells and carry specific surface markers of the original tumor cells. substantial evidence has implicated texs as attractive diagnostic markers for cancer. however, the detection of texs in blood at an early tumor stage is challenging due to their very low concentration. here, we established a method called pla-rpa-tma assay that allows texs to be detected with high sensitivity and spe ... | 2018 | 29145073 |
| burkitt lymphoma and cavernous sinus syndrome with breast uptake on 18f-fdg-pet/ct: a case report. | burkitt lymphoma (bl) is a type of non-hodgkin lymphoma that arises in the b-cells. cavernous sinus involvement is rare, especially in adults. here we report an unusual case of a 30-year-old hiv-positive woman with bl and cavernous sinus syndrome who also had intense bilateral breast uptake, related to menstrual cycle. fluorine-18 2-fluoro-2-deoxyglucose (18f-fdg) positron emission tomography/computed tomography (pet/ct) has been found to be useful in the management of bl. | 2017 | 29145302 |
| spontaneous development of epstein-barr virus associated human lymphomas in a prostate cancer xenograft program. | prostate cancer research is hampered by the lack of in vivo preclinical models that accurately reflect patient tumour biology and the clinical heterogeneity of human prostate cancer. to overcome these limitations we propagated and characterised a new collection of patient-derived prostate cancer xenografts. tumour fragments from 147 unsupervised, surgical prostate samples were implanted subcutaneously into immunodeficient rag2-/-γc-/- mice within 24 hours of surgery. histologic and molecular cha ... | 2017 | 29145505 |
| retroperitoneal inflammatory myofibroblastic tumor: case report and immunohistochemistry study. | inflammatory myofibroblastic tumors (imt) are a rare clinicopathological entity of yet unknown etiology and those located retroperitoneally are even rarer. clinical outcome is unpredictable and complete surgical resection of the tumor remains the principal treatment. we report the case of a 41-year old man presented with abdominal pain. an abdominal magnetic resonance imaging scan revealed a retroperitoneal tumor located between the pancreas, stomach small curvature and big vessels. a laparotomy ... | 2010 | 29147187 |
| hemophagocytic lymphohistiocytosis in association with clostridium difficile infection and cutaneous t-cell lymphoma. | hemophagocytic lymphohistiocytosis (hlh) or macrophage activation syndrome (mas) is a potentially life threatening disorder that presents with fever, suppressed blood cell counts, hepatosplenomegaly and multi-organ failure. hlh has been reported in association with genetic mutations, infections, autoimmune disorders, and various malignancies. however to the best of our knowledge, hlh in association with clostridium difficile infection has never been reported. we present a case of hlh in a patien ... | 2011 | 29147237 |
| spontaneous hepatic rupture associated with epstein-barr virus negative aggressive natural killer cell leukemia. | aggressive natural killer cell leukemia (ankl) is a rare subtype of large granular lymphocyte (lgl) leukemia, which typically presents in young adults of asian descent. it is an aggressive disease, characterized initially by fever, pancytopenia and hepatosplenomegaly, which rapidly progresses to organ failure and death over the course of months. spontaneous hemorrhagic complications have been reported to occur in ankl in a handful of case reports, including lethal intestinal and cerebral hemorrh ... | 2014 | 29147405 |
| prognostic value of molecular markers and implication for molecular targeted therapies in nasopharyngeal carcinoma: an update in an era of new targeted molecules development. | the aim of the study was to evaluate the prognostic significance of molecular biomarkers which could provide information for more accurate prognostication and development of novel therapeutic strategies for nasopharyngeal carcinoma (npc). npc is a unique malignant epithelial carcinoma of head and neck region, with an intimate association with the epstein-barr virus (ebv). currently, the prediction of npc prognosis is mainly based on the clinical tnm staging; however, npc patients with the same c ... | 2015 | 29147412 |
| host immune response index in gastric cancer identified by comprehensive analyses of tumor immunity. | tumor infiltrating lymphocytes (til) in epstein-barr virus (ebv)-associated/microsatellite-unstable (msi) gastric carcinomas (gc) constitute immune-active principal cellular components of tumor microenvironment and contribute to better prognosis. with the remarkable success of cancer immunotherapies, there is an urgent need for a comprehensive understanding of tumor-immune interactions in patients with gc in the context of host immune response. to identify gc subtype-specific immune response gen ... | 2017 | 29147610 |
| the alice-in-wonderland syndrome. | in 1955, english psychiatrist john todd defined the alice-in-wonderland syndrome (aiws) as self-experienced paroxysmal body-image illusions involving distortions of the size, mass, or shape of the patient's own body or its position in space, often accompanied by depersonalization and/or derealization. aiws had been described by american neurologist caro lippman in 1952, but todd's report was the most influential. todd named the syndrome for the perceptual disorder of altered body image experienc ... | 2018 | 29151098 |
| [atypical profile problem in serological diagnosis of ebv]. | epstein-barr virus (ebv) is the causative agent of infectious mononucleosis. burkitt's lymphoma, nasopharyngeal carcinoma and post-transplant lymphoproliferative diseases are also associated with ebv. diagnosis is frequently based on detection of specific antibodies. using three parameters (anti vca-igm, anti vca-igg and anti ebna-1 igg), it is possible to define infection status and diagnose acute or past infection. however, sometimes the detection of atypical serological profiles makes it diff ... | 2017 | 29153068 |
| conformational dynamics and free energy of bhrf1 binding to bim bh3. | the interaction between the bim bh3 peptide and the viral protein bhrf1 is pivotal to understanding the fundamental molecular details of the mechanism used by the epstein-barr virus to trick the mammalian immune system. here, we study the mechanism of binding/unbinding and compute the free energy for the association of the bim peptide to the bhrf1 protein. key elements of the binding mechanism are the conformational rearrangement together with a main free energy barrier of 11.5kcal/mol. the simu ... | 2018 | 29153883 |
| immune activation and benefit from avelumab in ebv-positive gastric cancer. | response to immune checkpoint therapy can be associated with a high mutation burden, but other mechanisms are also likely to be important. we identified a patient with metastatic gastric cancer with meaningful clinical benefit from treatment with the anti-programmed death-ligand 1 (pd-l1) antibody avelumab. this tumor showed no evidence of high mutation burden or mismatch repair defect but was strongly positive for presence of epstein-barr virus (ebv) encoded rna. analysis of the cancer genome a ... | 2017 | 29155997 |
| retraction: the epstein-barr virus-encoded mir-bart22 targets map3k5 to promote host cell proliferative and invasive abilities in nasopharyngeal carcinoma. | [this retracts the article doi: 10.7150/jca.15753.]. | 2017 | 29158784 |
| [infection by the epstein-barr virus between the years 2006-2015 in the health area of santiago de compostela. relationship with age and sex]. | in spain, the age and sex to which the primary infection by ebv is produced is poorly studied. the objective of this work is to know its relation with the presence of the primary infection by ebv between the years 2006 and 2015 in our health area. | 2017 | 29160648 |
| therapeutic strategies against epstein-barr virus-associated cancers using proteasome inhibitors. | epstein-barr virus (ebv) is closely associated with several lymphomas (endemic burkitt lymphoma, hodgkin lymphoma and nasal nk/t-cell lymphoma) and epithelial cancers (nasopharyngeal carcinoma and gastric carcinoma). to maintain its persistence in the host cells, the virus manipulates the ubiquitin-proteasome system to regulate viral lytic reactivation, modify cell cycle checkpoints, prevent apoptosis and evade immune surveillance. in this review, we aim to provide an overview of the mechanisms ... | 2017 | 29160853 |
| impact of chronic viral infection on t-cell dependent humoral immune response. | during the last decades, considerable efforts have been done to decipher mechanisms supported by microorganisms or viruses involved in the development, differentiation, and function of immune cells. pathogens and their associated secretome as well as the continuous inflammation observed in chronic infection are shaping both innate and adaptive immunity. secondary lymphoid organs are functional structures ensuring the mounting of adaptive immune response against microorganisms and viruses. inside ... | 2017 | 29163507 |
| cd56-negative aggressive nk cell leukemia relapsing as multiple cranial nerve palsies: case report and literature review. | aggressive natural killer cell leukemia (ankl) is extremely rare and habitually manifests as a systemic disease with multiorgan failure that rapidly evolves to death. the neoplastic natural killer (nk) cells usually harbor the epstein-barr virus (ebv) with a latent viral infection pattern type ii; they often have a cytoplasmic cd3ε+ and surface cd3-, cd2+, and cd56+ immunophenotype, and they show complex genetic abnormalities affecting multiple tumor suppressor genes and oncogenes. we present a ... | 2017 | 29163992 |
| tick-borne transmission of murine gammaherpesvirus 68. | herpesviruses are a large group of dna viruses infecting mainly vertebrates. murine gammaherpesvirus 68 (mhv68) is often used as a model in studies of the pathogenesis of clinically important human gammaherpesviruses such as epstein-barr virus and kaposi's sarcoma-associated herpesvirus. this rodent virus appears to be geographically widespread; however, its natural transmission cycle is unknown. following detection of mhv68 in field-collected ticks, including isolation of the virus from tick sa ... | 2017 | 29164067 |
| clinicopathological and immunohistochemical study of head and neck langerhans cell histiocytosis from latin america. | langerhans cell histiocytosis (lch) is an inflammatory myeloid neoplastic proliferation with variable clinical behavior caused by the accumulation of cd1a+/cd207+ histiocytes, associated with a variable number of eosinophils, lymphocytes, plasma cells and multinucleated giant cells, most commonly observed in male children. lch is uncommon in the head and neck region, occurring as ulcerated and reddened plaques or nodules that cause destruction of adjacent soft tissues and bone. the exact etiolog ... | 2017 | 29164473 |
| a case of hodgkin lymphoma mimicking lymphomatoid granulomatosis diagnosed at autopsy. | hodgkin lymphoma and lymphomatoid granulomatosis (lyg) are entities that contain a small number of large, variably epstein-barr virus (ebv)-positive neoplastic cells scattered within background non-neoplastic mixed inflammatory infiltrate. the 2 entities can typically be distinguished histologically by the angiocentric and angiodestructive pattern of lymphomatoid granulomatosis (lyg); also, they differ in overall prognosis. herein, we report a case of hodgkin lymphoma in a 64-year-old caucasian ... | 2017 | 29165611 |
| human herpesvirus 8 in perinatally hiv-infected children with interstitial lung disease. | human herpesvirus 8 (hhv-8) is associated with the pathogenesis of kaposi sarcoma and interstitial pneumonitis in adults. this study aims to evaluate association between hhv-8 and interstitial lung disease in hiv-infected children. | 2017 | 29165615 |
| genomic profiles of nasopharyngeal carcinoma: the importance of histological subtyping and epstein-barr virus in situ assays. | 2018 | 29165785 | |
| reply to genomic profiles of nasopharyngeal carcinoma: the importance of histological subtyping and epstein-barr virus in situ assays. | 2018 | 29165787 | |
| acute cerebellitis in adults: a case report and review of the literature. | acute cerebellitis is a rare disease with the majority of cases described in children. little is known about the clinical characteristics and outcome in adults. | 2017 | 29166939 |
| acute viral infections of the central nervous system, 2014-2016, greece. | in order to investigate the viral etiology of acute infections of central nervous system (cns), multiplex and single pcrs combined with serology for arboviruses were applied on samples from 132 hospitalized patients in greece during may 2014-december 2016. a viral pathogen was detected in 52 of 132 (39.4%) cases with acute cns infection. enteroviruses predominated (15/52, 28.8%), followed by west nile virus (9/52, 17.3%). phleboviruses, varicella-zoster virus, and epstein-barr virus accounted fo ... | 2017 | 29168889 |
| [how to manage ebv reactivation and ebv-ptld, cmv and human herpesvirus 6 reactivation and infection after allogeneic stem cell transplantation: a report of the sfgm-tc (update)]. | the french society of bone marrow transplantation and cell therapy (sfgm-tc) organizes annually workshops in the attempt to harmonize clinical practices between different francophone transplantation center. here, we report our recommendations regarding the management of epstein barr virus reactivation and lymphoproliferative disorders, cytomegalovirus (cmv) and human herpes virus 6 (hhv6) after allogeneic stem cell transplantation. | 2017 | 29169653 |
| rapamycin enhances lytic replication of epstein-barr virus in gastric carcinoma cells by increasing the transcriptional activities of immediate-early lytic promoters. | epstein-barr virus (ebv), a human herpesvirus, is linked to both epithelial and lymphoid malignancies. induction of ebv reactivation is a potential therapeutic strategy for ebv-associated tumors. in this study, we assessed the effects of rapamycin on ebv reactivation in gastric carcinoma cells. we found that rapamycin upregulated expression of ebv lytic proteins and increased the viral proliferation triggered by the ebv lytic inducer sodium butyrate. reverse transcription-qpcr, luciferase activi ... | 2017 | 29169830 |
| outcomes among us patients with diffuse large b cell lymphoma are independent of tumor epstein barr virus positivity or immunosuppression. | the prevalence, presenting clinical and pathologic characteristics, and outcomes for patients with diffuse large b-cell lymphoma that is epstein-barr virus positive remains uncertain as does the impact of congenital or iatrogenic immunosuppression. patients with newly diagnosed diffuse large b-cell lymphoma with available tissue arrays were identified from the university of iowa/mayo clinic molecular epidemiology resource. patients with human immunodeficiency virus or prior organ transplant were ... | 2017 | 29170255 |
| epstein-barr virus (ebv) associated reactive and indeterminate lymphoid proliferations in the lymph node. | 2017 | 29174725 | |
| atypical epstein-barr virus-associated hemophagocytic lymphohistiocytosis simulating lymphadenitis on 18f-fdg pet/ct and its differential diagnosis. | diagnosis of epstein-barr virus-associated hemophagocytic lymphohistiocytosis (ebv-hlh) is challenging as its clinical presentation is atypical. here we present a case of atypical ebv-hlh simulating lymphadenitis on fluorrine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18f-fdg pet/ct), with a view to consider this kind of ebv-hlh as a possible differential diagnosis in lymphadenitis. a 68 years old male who had episodic fever accompanied by weight loss and weakness fo ... | 2017 | 29177266 |
| no indication of increased infection rates using low-dose alemtuzumab instead of anti-thymocyte globulin as graft-versus-host disease prophylaxis before allogeneic stem cell transplantation. | alemtuzumab as part of the conditioning protocol is effective in reducing graft-versus-host disease (gvhd), but may be associated with increased infection rates, especially when using high doses (ie, 100 mg). | 2017 | 29178248 |
| selective t-cell depletion targeting cd45ra reduces viremia and enhances early t-cell recovery compared with cd3-targeted t-cell depletion. | t-cell depletion (tcd) effectively reduces severe graft-versus-host disease in recipients of hla-mismatched allografts. however, tcd is associated with delayed immune recovery and increased infections. we hypothesized that specific depletion of cd45ra+ naive t cells, rather than broad depletion of cd3+ t cells, can preserve memory-immunity in the allografts and confer protection against important viral infections in the early post-transplant period. | 2017 | 29178554 |
| comprehensive review of post-organ transplant hematologic cancers. | a higher risk for a variety of cancers is among the major complications of posttransplantation immunosuppression. in this part of a continuing series on cancers posttransplantation, this review focuses on the hematologic cancers after solid organ transplantation. posttransplantation lymphoproliferative disorders (ptlds), which comprise the great majority of hematologic cancers, represent a spectrum of conditions that include, but are not limited to, the hodgkin and non-hodgkin lymphomas. the onc ... | 2017 | 29178667 |
| [detection of herpes virus and human enterovirus in pathology samples using low-density arrays]. | despite the frequency of infections with herpesviridae family, only eight subtypes affect humans (herpex simplex virus types 1 and 2, varicella zoster virus, epstein-barr virus, citomegalovirus and human herpes virus types 6, 7 and 8). amongst enteroviruses infections, the most important are poliovirus, coxackievirus and echovirus. symptoms can vary from mild to severe and early diagnosis is of upmost importance. nowadays, low-density arrays can detect different types of viruses in a single assa ... | 2017 | 29179969 |
| viral unmasking of cellular 5s rrna pseudogene transcripts induces rig-i-mediated immunity. | the sensor rig-i detects double-stranded rna derived from rna viruses. although rig-i is also known to have a role in the antiviral response to dna viruses, physiological rna species recognized by rig-i during infection with a dna virus are largely unknown. using next-generation rna sequencing (rnaseq), we found that host-derived rnas, most prominently 5s ribosomal rna pseudogene 141 (rna5sp141), bound to rig-i during infection with herpes simplex virus 1 (hsv-1). infection with hsv-1 induced re ... | 2018 | 29180807 |
| development of lymphoma from the donor of haploidentical stem cell transplantation: a case report. | post-transplantation lymphoproliferative disease (ptld) is a serious complication following hematopoietic stem cell transplantation (hsct). the majority of the cases develop during the first year after the transplantation and are associated with reactivation of the epstein-barr virus (ebv); the ebv-induced lymphoproliferation usually includes donor-derived b cells. we herein describe the case of a 28-year-old female patient who developed ebv-negative ptld, namely diffuse large b-cell lymphoma (d ... | 2017 | 29181178 |
| [large b-cell lymphoma coexisting with castleman's disease. report of one case]. | we report a 73-year-old female patient with castleman's disease coexistent with large b cell type non-hodgkin's lymphoma in a right axillary lymphadenopathy. an excisional biopsy was performed: microscopically, the lymph node revealed the presence of numerous plasma cells and small lymphoid cells characteristic of castleman's disease. an analysis of another portion of the specimen revealed lymphoid cells with large abnormal nuclei gathered locally that were cdd 79+, cd 38+ and mum-1+ as well as ... | 2017 | 29182205 |
| a rare case of esophageal lymphoepithelial carcinoma without epstein-barr virus infection. | 2017 | 29183763 | |
| plasma ebv micrornas in paediatric renal transplant recipients. | epstein-barr virus (ebv) was the first human virus identified to express microrna (mirna). to date, 44 mature mirnas are encoded for within the ebv genome. ebv mirnas have not been profiled in paediatric renal transplant recipients. in this study, we investigated circulating ebv mirna profiles as novel biomarkers in paediatric renal transplant patients. | 2017 | 29185211 |
| viral oncology: molecular biology and pathogenesis. | oncoviruses are implicated in approximately 12% of all human cancers. a large number of the world's population harbors at least one of these oncoviruses, but only a small proportion of these individuals go on to develop cancer. the interplay between host and viral factors is a complex process that works together to create a microenvironment conducive to oncogenesis. in this review, the molecular biology and oncogenic pathways of established human oncoviruses will be discussed. currently, there a ... | 2017 | 29186062 |
| analysis of dna topology of ebv minichromosomes in hek 293 cells. | simian virus 40 (sv40) and epstein-barr virus (ebv) are frequently used as model systems to study dna replication. their genomes are both circular duplex dnas organized in a single replicon where replication initiates at a precise site upon binding of a specific protein: the large tumor (t) antigen for sv40 and the epstein-barr nuclear antigen 1 (ebna-1) for ebv. despite the abundant information available on the genetics and biochemistry of the replication process in these systems, little is kno ... | 2017 | 29186176 |
| relationship between ppp1r15a gene polymorphism (rs611251) and epstein-barr virus-associated tumors. | protein phosphatase 1, regulatory subunit 15a (ppp1r15a), also known as growth arrest and dna damage-inducible protein gadd34, plays a vital role in promoting cell death and the unfolded protein response (upr). in order to explore whether the snp (rs611251) of ppp1r15a gene has a role in different types of epstein-barr virus (ebv) - associated tumors, we detected the ppp1r15a gene rs611251 polymorphism in 195 cases of ebv positive tumors (93 lymphomas, 48 gastric carcinomas, 54 nasopharyngeal ca ... | 2017 | 29186961 |
| [symmetrical lesions of the cerebral peduncles and internal capsules on mri in a patient with extranodal nk/t cell lymphoma]. | a 72-year-old man was admitted to our hospital because of subacute progressive consciousness disturbance. flair images showed diffuse high intensity areas in the bilateral thalamus, basal ganglia, and white matter. chest ct revealed a mass in the right lung. the patient was diagnosed with extranodal natural killer/t cell lymphoma (enkl) according to the results of a biopsy of the right pulmonary mass. the flair images showed diffuse white matter lesions, without a mass such as lymphomatosis cere ... | 2017 | 29187687 |
| infusions of epstein-barr virus-specific cytotoxic t lymphocytes as post-remission therapy in high-risk post-transplant lymphoproliferative disorder patients: report of two cases. | conventional therapeutic approaches to post-transplant lymphoproliferative disorder (ptld) occurring after solid-organ transplantation have shown only limited success in achieving durable response. key factors driving the pathogenesis of ptld include epstein-barr virus (ebv) reactivation and impaired immune surveillance due to prolonged immune suppression. thus, ebv-specific cytotoxic t lymphocytes (ebv-ctls) have emerged as an alternative therapeutic approach for the treatment of ebv-associated ... | 2017 | 29188583 |
| viral dnaemia and immune suppression in pediatric sepsis. | demonstrate that dna viremia is common in pediatric sepsis and quantitate its associations with host immune function and secondary infection risk. | 2018 | 29189638 |
| epstein-barr virus clonality and plasmacytosis in a patient with atypical angioimmunoblastic t cell lymphoma. | 2017 | 29189897 | |
| in response to: smit d, meyer d, maritz j, et al. "polymerase chain reaction and goldmann-witmer coefficient to examine the role of epstein-barr virus in uveitis". | 2017 | 29190161 | |
| pretreatment epstein-barr virus dna in whole blood is a prognostic marker in peripheral t-cell lymphoma. | because there are few studies regarding the clinical impact of circulating ebv-dna in peripheral t-cell lymphomas (ptcls), we tried to evaluate the role of ebv-dna in whole blood as a prognostic factor for ptcl. we retrospectively reviewed 110 ptcl patients with median age of 63 (20-94) years. forty-seven patients (42.7%) showed positive results for ebv-dna, and these patients also had stage iii/iv disease, elevated lactic dehydrogenase, and low albumin level (p = 0.007, p = 0.004, p = 0.002, re ... | 2017 | 29190917 |
| clinical significance of plasma epstein-barr virus dna in pulmonary lymphoepithelioma-like carcinoma (lelc) patients. | 2017 | 29191777 | |
| characterization of the ebv-induced persistent dna damage response. | epstein-barr virus (ebv) is an oncogenic herpesvirus that is ubiquitous in the human population. early after ebv infection in vitro, primary human b cells undergo a transient period of hyper-proliferation, which results in replicative stress and dna damage, activation of the dna damage response (ddr) pathway and, ultimately, senescence. in this study, we investigated ddr-mediated senescence in early arrested ebv-infected b cells and characterized the establishment of persistent dna damage foci. ... | 2017 | 29194355 |
| methotrexate-associated lymphoproliferative disease with multiple pulmonary nodules in a patient with rheumatoid arthritis. | a 62-year-old woman with rheumatoid arthritis and secondary sjögren's syndrome took methotrexate (mtx) 5 mg three times a week regularly but gradually developed an intermittent fever, oral ulcers and productive cough with mucopurulent sputum for about 2 weeks. image study found multiple nodular lesions and lymphadenopathies in bilateral lungs. empirical antibiotics for 1 week failed to alleviate the fever. a transbronchial biopsy in the right fourth bronchus showed infiltration of abnormally enl ... | 2017 | 29196307 |
| potential cancer chemopreventive and anticancer constituents from the fruits of ficus hispida l.f. (moraceae). | ficus hispida l.f. (moraceae) has been used as alternative for traditional medicine in the treatment of various ailments including cancer-cure. the aim of this study was to evaluate the cancer chemopreventive and anticancer activities of crude extracts of f. hispida, with the objective to screen the inhibition of epstein-barr virus early antigen, and cytotoxic active components, and provide foundation for potential applications of this promising medical plant. | 2018 | 29197545 |
| ebv+ hhv-8+ multicentric castleman disease with plasmablastic aggregates in an hiv+ man: an evolving clinicopathologic entity. | we report a case of ebv+ and hhv-8+ multicentric castleman disease with plasmablastic aggregates in an hiv-positive individual. a 41-year-old man presented in early 2015 with fevers, sweats, weight loss, intractable itching, and on subsequent testing was found to be hiv positive. investigations showed cervical lymphadenopathy and splenomegaly. he was treated for hiv and his symptoms resolved. his symptoms recurred in january 2016, and a provisional diagnosis of multicentric castleman disease was ... | 2017 | 29198143 |
| comparison of abbott architect®, siemens immulite®, and diasorin liaison® for determination of epstein-barr virus serological diagnosis. | this study compared the performance of 3 automated immunoassays, architect® (abbott), immulite® (siemens) and liaison® (diasorin), for epstein-barr virus (ebv) serology. ninety-one serum samples collected in amiens university hospital were analyzed for the presence of viral capsid antigen (vca) igg and igm and epstein-barr nuclear antigen (ebna) igg. the agreement between the 3 assays was calculated for each marker individually and for determination of the ebv profile, based on interpretation of ... | 2018 | 29198371 |
| peroxiredoxin-2 and zinc-alpha-2-glycoprotein as potentially combined novel salivary biomarkers for early detection of oral squamous cell carcinoma using proteomic approaches. | no effective screening method is available for oral squamous cell carcinoma (oscc) that is recognized to influence by environmental factors as well as human papillomavirus (hpv) and epstein-barr virus (ebv). therefore, we sought to identify salivary biomarkers for screening of oscc with or without hpv and/or ebv infection. saliva, lesion and oral exfoliated cells were collected from oscc patients and cancer-free controls (cfcs) and grouped depending on their hpv- and ebv-infection status. saliva ... | 2018 | 29199150 |
| clinical challenges: identification of patients with novel primary immunodeficiency syndromes. | novel primary immunodeficiency disorders are being identified with next generation sequencing technologies. we describe 1 patient with cytotoxic t-lymphocyte-associated protein 4 (ctla-4) haploinsufficiency who had recurrent enhancing brain lesions, nodular pulmonary infiltrates, hepatosplenomegaly, immune cytopenias, as well as progressive hypogammaglobulinemia and lymphopenia. we describe a second patient with activated p110δ syndrome (apds)/p110δ activating mutation causing senescent t cells, ... | 2017 | 29200144 |
| a rare case of chronic active epstein-barr virus (ebv) infection accompanied by the infiltration of ebv-infected cd8+ t cells into the muscle. | we describe a rare case of chronic active epstein-barr virus (caebv) infection, with infiltration of the skeletal muscle. a 19-year-old woman with swollen cervical lymph nodes and a fever was referred to our hospital. swelling of the trapezium muscle and elevation of creatinine kinase level were observed. biopsy results of the brachialis muscle revealed infiltration of epstein-barr virus (ebv)-encoded rna-positive cd8 t lymphocytes. the ebv virus load in the peripheral blood was high, and ebv mo ... | 2017 | 29200172 |
| epstein-barr virus and cytomegalovirus induced acute hepatitis in young female patient. | acute hepatitis is a disorder that goes with liver cell necrosis and liver inflammation. among the causes of acute hepatitis, the most common reasons are viral hepatitis. about 95% of the acute hepatitis generate because of hepatotropic viruses. epstein-barr virus (ebv) and cytomegalovirus (cmv) are from the family of herpes viruses and rare causes of acute hepatitis. in this case report, acute hepatitis due to ebv and cmv coinfection will be described. | 2017 | 29201691 |
| epstein-barr virus induces adhesion receptor cd226 (dnam-1) expression during primary b-cell transformation into lymphoblastoid cell lines. | epstein-barr virus (ebv), an oncogenic herpesvirus, infects and transforms primary b cells into immortal lymphoblastoid cell lines (lcls), providing a model for ebv-mediated tumorigenesis. ebv transformation stimulates robust homotypic aggregation, indicating that ebv induces molecules that mediate cell-cell adhesion. we report that ebv potently induced expression of the adhesion molecule cd226, which is not normally expressed on b cells. we found that early after infection of primary b cells, e ... | 2017 | 29202043 |
| the role of the early social environment on epstein barr virus infection: a prospective observational design using the millennium cohort study. | epstein-barr virus (ebv) is a highly prevalent herpesvirus linked to infectious mononucleosis and several malignancies. this paper aims to study the association between children's early life social environment at 9 months and ebv infection at 3 years of age. | 2017 | 29202893 |
| lymphoepithelial carcinoma: a case report of a rare tumor of the larynx. | lymphoepithelial carcinoma is a tumor mostly diagnosed in the nasopharynx, but it has also been described in a variety of nonnasopharyngeal sites. it is extremely rare in the larynx and should be distinguished from squamous cell carcinoma. therefore, it must be known by clinicians, pathologists and oncologists. in this case report, we discuss its etiopathogeny, its epidemiological, clinical, pathological and therapeutic aspects, and its outcome. | 2017 | 29204101 |