Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| co-infections by double-stranded dna viruses after ex vivo t cell-depleted, cd34(+) selected hematopoietic cell transplantation. | recipients of ex vivo t cell-depleted (tcd) hematopoietic cell transplantation (hct) are at risk of infection by double-stranded (ds) dna viruses. we report rates of dsdna viremia, end-organ disease (eod), infection-related mortality, and overall survival (os) in a contemporary cohort of adult tcd hct recipients routinely monitored for cytomegalovirus (cmv), adenovirus (adv), human herpesvirus 6 (hhv6), and epstein-barr virus (ebv). healthcare utilization in the first 6 months post-hct was compa ... | 2017 | 28668490 |
| characterization and serotype distribution of aggregatibacter actinomycetemcomitans: relationship of serotypes to herpesvirus and periodontal status in indian subjects. | the virulence of aggregatibacter actinomycetemcomitans (a. actinomycetemcomitans) in any individual depends on the type of strain of this bacterium. to our knowledge, there have been no studies reported in indian subjects about a. actinomycetemcomitans serotype occurrence, co-existence with herpes virus and the possible influence of such co-existence on periodontal pathology. | 2017 | 28668607 |
| an update: epstein-barr virus and immune evasion via microrna regulation. | epstein-barr virus (ebv) is an oncogenic virus that ubiquitously establishes life-long persistence in humans. to ensure its survival and maintain its b cell transformation function, ebv has developed powerful strategies to evade host immune responses. emerging evidence has shown that micrornas (mirnas) are powerful regulators of the maintenance of cellular homeostasis. in this review, we summarize current progress on how ebv utilizes mirnas for immune evasion. ebv encodes mirnas targeting both v ... | 2017 | 28669004 |
| oral shedding of human herpesviruses in renal transplant recipients. | to describe the shedding profile of human herpesviruses in the saliva of renal transplant recipients. | 2017 | 28669106 |
| molecular screening for epstein-barr virus (ebv): detection of genomic ebna-1, ebna-2, lmp-1, lmp-2 among vietnamese patients with nasopharyngeal brush samples | epstein-bar virus (ebv) is considered to be intimately associated with development of nasopharyngeal carcinoma (npc), the most common and high incidence cancer of the head and neck in asian countries, especially in vietnam. in this study, we validated associations between highly conserved segments of the ebv genome, including ebna-1, ebna-2, lmp-1, lmp-2 and nasopharyngeal cancer, with the aim of applications with non-invasive brush samples for early diagnosis and as a prognostic biomarker. the ... | 2017 | 28670888 |
| clinical analysis of 42 cases of ebv-positive mature t/nk-cell neoplasms. | the pathogenesis of epstein-barr virus-positive (ebv(+)) mature t-cell and natural killer (nk)-cell neoplasms is challenging to understand. the clinical features are diverse, with no typical manifestation. therefore, it is important to analyze the association of the clinical characteristics and prognoses of patients with various factors associated with ebv(+) t/nk-cell neoplasms, particularly extranodal nk/t cell lymphoma, systemic ebv(+) t/nk cell lymphoproliferative disorders, aggressive nk ce ... | 2017 | 28672968 |
| evaluation of seven recombinant vca-iga elisa kits for the diagnosis of nasopharyngeal carcinoma in china: a case-control trial. | seven recombinant viral capsid antigen-iga (vca-iga) elisa kits are widely used in china, but their diagnostic effects have not been evaluated. in this study, we evaluated whether the diagnostic effects of these kits are similar to those of the standard kit (euroimmun, lübeck, germany). | 2017 | 28674124 |
| radiation-induced epstein-barr virus reactivation in gastric cancer cells with latent ebv infection. | epstein-barr virus, a ubiquitous human herpes virus with oncogenic activity, can be found in 6%-16% of gastric carcinomas worldwide. in epstein-barr virus-associated gastric carcinoma, only a few latent genes of the virus are expressed. ionizing irradiation was shown to induce lytic epstein-barr virus infection in lymphoblastoid cell lines with latent epstein-barr virus infection. in this study, we examined the effect of ionizing radiation on the epstein-barr virus reactivation in a gastric epit ... | 2017 | 28675108 |
| current treatment approaches for nk/t-cell lymphoma. | extranodal nk/t-cell lymphoma, nasal type (enkl), is a form of lymphoma characterized by preferential extranodal involvement, epstein-barr virus (ebv) association, and geographic diversity in incidence. enkl tumor cells express p-glycoprotein, which is related to multidrug resistance (mdr). this mdr phenomenon is thought to be the major reason why enkl is resistant to anthracycline-containing chemotherapies and has led researchers to explore novel therapeutic strategies. since the early 2000s, n ... | 2017 | 28679966 |
| virus-specific cytotoxic t cells in chronic active epstein-barr virus infection. | chronic active epstein-barr virus infection (caebv) is a disease characterized by clonally proliferating and activated ebv-infected t or nk cells accompanied by chronic inflammation and t- or nk-cell neoplasms. however, the mechanism for developing caebv has not been clarified to date. because the decreased number or inactivation of ebv-specific cytotoxic t lymphocytes (ctls) resulted in the development of ebv-positive b-cell neoplasms, we investigated the number of ctls in caebv patients using ... | 2017 | 28679986 |
| iatrogenic immunodeficiency-associated epstein-barr virus (ebv) -negative natural killer cell lymphoproliferative disorder in a patient undergoing rheumatoid arthritis therapy. | here we present a patient with rheumatoid arthritis (ra), who was suspected to have developed malignant lymphoma during immunosuppressive therapy 5 years earlier. she temporarily achieved remission after discontinuing therapy; however, her disease worsened with remittent fever and splenomegaly. splenic biopsy demonstrated infiltration by abnormal cells, which were positive for cd56 and t cell intracytoplasmic antigen, but negative for cd3 and epstein-barr virus (ebv) -encoded rna. cytogenetic an ... | 2017 | 28679993 |
| nucleolin directly mediates epstein-barr virus immune evasion through binding to g-quadruplexes of ebna1 mrna. | the oncogenic epstein-barr virus (ebv) evades the immune system but has an achilles heel: its genome maintenance protein ebna1, which is essential for viral genome maintenance but highly antigenic. ebv has seemingly evolved a system in which the mrna sequence encoding the glycine-alanine repeats (gar) of the ebna1 protein limits its expression to the minimal level necessary for function while minimizing immune recognition. here, we identify nucleolin (ncl) as a host factor required for this proc ... | 2017 | 28685753 |
| cancer incidence attributable to lifestyle and environmental factors in alberta in 2012: summary of results. | estimates of the proportion of cancer cases that can be attributed to modifiable risk factors are not available for canada and, more specifically, alberta. the purpose of this study was to estimate the total proportion of cancer cases in alberta in 2012 that could be attributed to a set of 24 modifiable lifestyle and environmental risk factors. | 2017 | 28687643 |
| a rare case of epstein-barr virus mucocutaneous ulcer of the colon. | epstein-barr virus mucocutaneous ulcer (ebvmcu) is a rare form of ebv lymphoproliferative disorder. the disease was recently described in 2010 for the first time in a case series and it was recently identified by the who classification of haematological malignancies as a separate category among the ebv lymphoproliferative disorders. we present a case of ebvmcu of the colon presenting as an ulcerating inflammatory mass in a female in her mid-60s who presented initially with abdominal pain and dia ... | 2017 | 28687701 |
| cancer risk factors among people living with hiv/aids in china: a systematic review and meta-analysis. | cancer is a leading cause of death among people living with hiv/aids (plwha). we conducted a systematic review and meta-analysis to evaluate prevalence of cancer risk factors among chinese plwha based on 102 articles. random effects meta-analysis was used to calculate the summary prevalence estimate (sprev) and 95% confidence interval (ci) for each cancer risk factor by demographic group. overall, the sprev for each risk factor among chinese plwha was: 41.1% (95% ci: 35.3-46.9%) for current smok ... | 2017 | 28687813 |
| mycoplasma pneumoniae as a cause of vulvar ulcers in a non-sexually active girl: a case report. | non-sexually active young females very rarely develop genital ulcers. such ulcers pose a diagnostic challenge as well as physical and emotional distress for patients and family; therefore, the search for their etiology requires exhaustive investigation. several viruses such as epstein-barr virus have been associated with this entity; however, mycoplasma pneumoniae has rarely been linked to such ulcers in the literature. we present a case of vulvar ulcers in a non-sexually active young girl durin ... | 2017 | 28688453 |
| prognostic role of tumor infiltrating lymphocytes in ebv positive and ebv negative nasopharyngeal carcinoma. | tumor infiltrating lymphocytes (tils) correlate with both better and worse prognosis in solid tumors. as therapeutic modalities for nasopharyngeal carcinoma (npc) are limited, immunotherapy could be a potential alternative. up till now there is limited prognostic data on the role of tils in npc, so we assessed the prognostic role of tils in epstein-barr-virus (ebv) positive and negative npc. | 2017 | 28688685 |
| primary gastrointestinal anaplastic large cell lymphoma. | primary gastrointestinal anaplastic large cell lymphoma (gi-alcl) is rare. we report eight new cases. the median age was 61.5 years (range 10-88), most frequently involving the stomach (n = 3) and small intestine (n = 4). the neoplastic hallmark cells in all cases expressed cd30. anaplastic lymphoma kinase (alk) protein was expressed in two cases (25%). by in situ hybridisation, all cases were negative for epstein-barr virus and for dusp22/irf4 gene translocation. at a median follow-up time of 3 ... | 2017 | 28693749 |
| role of sirt1/pgc-1α in mitochondrial oxidative stress in autistic spectrum disorder. | autistic spectrum disorder (asd) is a neurodevelopmental disorder and has a high prevalence in children. recently, mitochondrial oxidative stress has been proposed to be associated with asd. besides, sirt1/pgc-1α signaling plays an important role in combating oxidative stress. in this study, we sought to determine the role of sirt1/pgc-1α signaling in the asd lymphoblastoid cell lines (lcls). in this study, the mrna and protein expressions of sirt1/pgc-1α axis genes were assessed in 35 children ... | 2017 | 28694700 |
| epstein-barr virus-negative extranodal "true" natural killer-cell lymphoma harbouring a kdm6a mutation. | extranodal natural killer (nk)/t-cell lymphoma, nasal type (enktl) is an extranodal aggressive t or nk-cell lymphoma that is characteristically associated with epstein-barr virus (ebv) infection and cytotoxic tissue-destructive features. although enktl is described as a distinct entity according to the 2008 who classification, a considerable complexity is associated with the differential diagnosis of other t-cell lymphomas with respect to tumour cell origins, locations, and the presence of ebv i ... | 2017 | 28695659 |
| lipschütz ulcers: a rare diagnosis in women with vulvar ulceration. | lipschütz ulcers are characterized by painful vulvar ulceration, most commonly in young women. because these lesions are so rarely seen, the diagnosis can be challenging. | 2017 | 28697104 |
| systemic epstein-barr virus-positive t-cell lymphoproliferative disease of childhood with good response to steroid therapy. | systemic epstein-barr virus (ebv)-positive t-cell lymphoproliferative disease of childhood is a rare disease and has a very fulminant clinical course with high mortality. a 21-month-old female patient was referred to our hospital with a 1 week history of fever and was subsequently diagnosed with systemic epstein-barr virus-positive t-cell lymphoproliferative disease of childhood. after starting treatment with dexamethasone, she showed early defervescence and improvement of laboratory parameters, ... | 2017 | 28697169 |
| primary intra-aortic epstein-barr virus-positive large b-cell lymphoma presenting as aortic mural thrombosis: an entity distinct from intravascular large b-cell lymphoma. | intravascular selective growth of neoplastic b lymphocytes is a characteristic finding of intravascular large b-cell lymphoma (ivlbcl). however, because neoplastic b cells of ivlbcl grow merely in the lumina of capillaries or small vessels, primary ivlbcl of the great vessels is considered exceptional. to our knowledge, only 2 primary b-cell lymphomas in the lumina of the vena cava have been reported. however, there has been no report of primary b-cell lymphoma with intra-aortic growth. we descr ... | 2017 | 28697692 |
| dual non-contiguous peptide occupancy of hla class i evoke antiviral human cd8 t cell response and form neo-epitopes with self-antigens. | host cd8 t cell response to viral infections involves recognition of 8-10-mer peptides presented by mhc-i molecules. however, proteasomes generate predominantly 2-7-mer peptides, but the role of these peptides is largely unknown. here, we show that single short peptides of <8-mer from latent membrane protein 2 (lmp2) of epstein barr virus (ebv) can bind hla-a*11:01 and stimulate cd8(+) cells. surprisingly, two peptide fragments between 4-7-mer derived from lmp2(340-349) were able to complement e ... | 2017 | 28698575 |
| epstein-barr virus (ebv) provides survival factors to ebv(+) diffuse large b-cell lymphoma (dlbcl) lines and modulates cytokine induced specific chemotaxis in ebv(+) dlbcl. | diffuse large b-cell lymphoma (dlbcl), the most common type of malignant lymphoma, accounts for 30% of adult non-hodgkin lymphomas. epstein-barr virus (ebv) -positive dlbcl of the elderly is a newly recognized subtype that accounts for 8-10% of dlbcls in asian countries, but is less common in western populations. five dlbcl-derived cell lines were employed to characterize patterns of ebv latent gene expression, as well as response to cytokines and chemotaxis. interleukin-4 and interleukin-21 mod ... | 2017 | 28699226 |
| an unusual association between hemophagocytic lymphohistiocytosis, mixed connective tissue disease, and autoimmune hemolytic anemia: a case report. | in the adult patient, hemophagocytic lymphohistiocytosis (hlh) is uncommon and frequently difficult to diagnose due to its nonspecific presentation and numerous complications. | 2017 | 28700492 |
| aged-associated cytomegalovirus and epstein-barr virus reactivation and cytomegalovirus relationship with the frailty syndrome in older women. | immunosenescence is an age-related reduction of immune system activity that can be associated with frailty. this study aimed to compare cytomegalovirus (cmv) and epstein-barr virus (ebv) reactivations (based on viremias) between young and elderly women who had a chronic cmv and/or ebv infection (i.e., an igg+ serostatus) without an acute infection (i.e., an igm- serostatus), and among the elderly group categorized according to frailty status. dna was extracted from plasma using standard protocol ... | 2017 | 28700679 |
| quantitative analysis of human leucocyte antigen expression during culture of epstein-barr virustransformed cell lines using the dako qifikit. | pre-existing donor-specific human leucocyte antigen (hla) antibodies in renal allograft recipients result in hyperacute and accelerated graft failure. these antibodies can be detected in flow cytometric assay systems using hla-characterised epstein-barr virus (ebv)-transformed b-lymphocyte cell lines. confident assay performance is predicated by the expression of hlas on the ebv-transformed b-cell line surface. surface hla expression of three ebv-transformed b-cell lines that had previously been ... | 2007 | 28700889 |
| the 150 most important questions in cancer research and clinical oncology series: questions 40-49. | since the beginning of 2017, chinese journal of cancer has published a series of important questions in cancer research and clinical oncology, which sparkle diverse thoughts, interesting communications, and potential collaborations among researchers all over the world. in this article, 10 more questions are presented as followed. question 40. why do mice being used as tumorigenesis models raised in different places or different conditions possess different tumor formation rate? question 41. how ... | 2017 | 28701224 |
| selective expression of ccr10 and cxcr3 by circulating human herpes simplex virus-specific cd8 t cells. | herpes simplex virus (hsv) infection is restricted to epithelial cells and neurons and is controlled by cd8 t cells. these cells both traffic to epithelial sites of recurrent lytic infection and to ganglia and persist at the dermal-epidermal junction for up to 12 weeks after lesion resolution. we previously showed that cutaneous lymphocyte-associated antigen (cla), a functional e-selectin ligand (esl), is selectively expressed on circulating hsv-2-specific cd8 t cells. cla/esl mediates adhesion ... | 2017 | 28701399 |
| structure and functional basis for an ebna1 hexameric ring in epstein-barr virus episome maintenance. | epstein-barr virus (ebv) establishes a stable latent infection that can persist for the life of the host. ebna1 is required for the replication, maintenance, and segregation of the latent episome but the structural features of ebna1 that confer each of these functions are not completely understood. here, we have solved the x-ray crystal structure of an ebna1 dna binding domain (dbd) and discovered a novel hexameric ring oligomeric form. the oligomeric interface pivoted around residue t585 as a j ... | 2017 | 28701406 |
| acute epstein - barr virus hepatitis without mononucleosis syndrome: a case report. | elevated liver enzymes accompanied by infectious mononucleosis syndrome are widely seen in primary epstein-barr virus infection while acute symptomatic hepatitis without typical presentations of ebv is extremely rare. in the following report, we present a patient with acute isolated hepatitis due to laboratory confirmed epstein-barr virus. | 2017 | 28702140 |
| eb virus reactivation triggers thrombotic thrombocytopenic purpura in a healthy adult. | thrombotic thrombocytopenic purpura (ttp) is rare but life-threatening disease, characterized typically by microangiopathic hemolytic anemia (maha), profound peripheral thrombocytopenia and severe deficiency in the von willebrand factor-cleaving prortease adamts13. it has been reported that acquired immune ttp is closely associated with human immunodeficiency virus infection and influenza infection or vaccination. however, it has not been reported to be associated with epstein barr virus infecti ... | 2017 | 28702343 |
| persistent kshv infection increases ebv-associated tumor formation in vivo via enhanced ebv lytic gene expression. | the human tumor viruses epstein-barr virus (ebv) and kaposi sarcoma-associated herpesvirus (kshv) establish persistent infections in b cells. kshv is linked to primary effusion lymphoma (pel), and 90% of pels also contain ebv. studies on persistent kshv infection in vivo and the role of ebv co-infection in pel development have been hampered by the absence of small animal models. we developed mice reconstituted with human immune system components as a model for kshv infection and find that ebv/ks ... | 2017 | 28704654 |
| effects of a new nutraceutical formulation (berberine, red yeast rice and chitosan) on non-hdl cholesterol levels in individuals with dyslipidemia: results from a randomized, double blind, placebo-controlled study. | increased non high-density lipoprotein (hdl)/low-density lipoprotein (ldl) cholesterol levels are independent risk factors for cardiovascular (cv) mortality with no documented threshold. a new combination of nutraceuticals (berberine 200 mg, monacolin k 3 mg, chitosan 10 mg and coenzyme q 10 mg) with additive lipid-lowering properties has become available. the aim of the study is to test the efficacy of the nutraceutical formulation (one daily) in lowering non-hdl cholesterol vs. placebo at 12 w ... | 2017 | 28704936 |
| acute generalized exanthema tous pustulosis (agep) associated to epstein-barr virus (ebv) infection reactivation. | 2017 | 28704988 | |
| conserved sequences of bart and bhrf regions encoding viral micrornas in epstein-barr virus-associated lymphoma. | epstein-barr virus (ebv) encodes at least 25 pri-micrornas (mirnas) in two regions of its dna genome, bart and bhrf. b95-8, an ebv reference strain, has a deletion in the bart region. however, no information is available on the deletions or mutations in the bart and bhrf regions in clinical samples of ebv-associated lymphoma. | 2017 | 28705173 |
| prevalence of ebv, hpv and mmtv in pakistani breast cancer patients: a possible etiological role of viruses in breast cancer. | breast cancer being a multifactorial disease, the role of infectious agent in development of disease is of great interest. the high incidence of breast cancer around the world has woken the interest in a viral etiology of breast cancer. despite decades of research, no etiologic factor(s) for human breast cancer has been known and the quest for a contributing cause has all but been abandoned during the past years. recent investigations have linked breast cancer to viral infections, such as epstei ... | 2017 | 28705719 |
| an immunocompetent patient with a recurrence-free ebv positive plasmacytoma possesses robust epstein-barr virus specific t cell responses. | 2017 | 28705903 | |
| mountain gorilla lymphocryptovirus has epstein-barr virus-like epidemiology and pathology in infants. | epstein-barr virus (ebv) infects greater than 90% of humans, is recognized as a significant comorbidity with hiv/aids, and is an etiologic agent for some human cancers. the critically endangered mountain gorilla population was suspected of infection with an ebv-like virus based on serology and infant histopathology similar to pulmonary reactive lymphoid hyperplasia (prlh), a condition associated with ebv in hiv-infected children. to further examine the presence of ebv or an ebv-like virus in mou ... | 2017 | 28706209 |
| the anecdote of viral etiopathogenia in ameloblastoma and odontogenic keratocyst: why don't we let it go? | ameloblastoma (am) and odontogenic keratocyst (okc) are destructive odontogenic lesions of the gnathion. although their exact pathogeneses are not yet totally understood, the viral etiopathogenesis in am and kcot has been proposed. true to syndromic keratocystic odontogenic tumor (skcot) and non-syndromic okc is the high recurrence rate. | 2017 | 28706783 |
| clinical utility of epstein-barr virus viral load monitoring and risk factors for posttransplant lymphoproliferative disorders after kidney transplantation: a single-center, 10-year observational cohort study. | posttransplant lymphoproliferative disease (ptld) is an important cause of morbidity and mortality in solid organ transplants. epstein barr virus (ebv) plays a major role in ptld development. guidelines recommend ebv viral load (vl) monitoring in high-risk populations in the first year. | 2017 | 28706985 |
| epstein-barr virus lytic cycle involvement in diffuse large b cell lymphoma. | epstein-barr virus (ebv)-mediated b cell transformation is achieved predominantly through the action of latent proteins, but recent evidence suggests that lytic ebv replication has also a certain pathogenic role in lymphomagenesis, at least in the early phases of cell transformation. particularly, in diffuse large b cell lymphoma (dlbcl), the ebv lytic cycle is by and large unexplored, so to disclose lytic cell contribution to lymphomagenesis, our aim was to evaluate viral early and late lytic g ... | 2017 | 28707331 |
| malaria, epstein-barr virus infection and the pathogenesis of burkitt's lymphoma. | a geographical and causal connection has long been recognized between malaria, epstein-barr virus (ebv) infection and burkitt's lymphoma (bl), but the underlying mechanisms remain obscure. potential clues are that the malaria parasite plasmodium falciparum selectively absorbs vitamin a from the host and depends on it for its biological activities; secondly, alterations in vitamin a (retinoid) metabolism have been implicated in many forms of cancer, including bl. the first author has proposed tha ... | 2017 | 28707393 |
| pretreatment serum amyloid a and c - reactive protein comparing with epstein-barr virus dna as prognostic indicators in patients with nasopharyngeal carcinoma: a prospective study. | the measuring epstein-barr virus (ebv) dna is an important predictor of nasopharyngeal carcinoma (npc). this study evaluated the predictive value of pretreatment serum amyloid a (saa) and c-reactive protein (crp) comparing with ebv dna in patients with npc. | 2017 | 28707462 |
| anti-n-methyl-d-aspartate receptor encephalitis and epstein-barr virus: another tale on autoimmunity? | 2017 | 28707812 | |
| a method for detecting rash and fever illness-associated viruses using multiplex reverse transcription polymerase chain reaction. | in this study, a new multiplex rt-pcr method for detecting various viral genes in patients with rash and fever illnesses (rfis) was constructed. new primer sets were designed for detection of herpes simplex viruses 1 and 2 (hsv1 and 2), and epstein-barr virus (ebv). the newly designed and previously reported primer sets were used to detect 13 types of rfi-associated viruses by multiplex rt-pcr assay systems. moreover, to eliminate non-specific pcr products, a double-stranded specific dnase was u ... | 2017 | 28710778 |
| expression of interferon regulatory factor 7 correlates with the expression of epstein-barr virus latent membrane protein 1 and cervical lymph node metastasis in nasopharyngeal cancer. | interferon regulatory factor 7 (irf7) has oncogenic properties in several malignancies such as epstein-barr virus (ebv)-associated lymphoma. however, there is no evidence whether irf7 is associated with the oncogenesis of nasopharyngeal cancer (npc), the pathogenesis of which is closely associated with ebv. herein, we report that expression of irf7 was increased in normal nasopharyngeal cells that expressed the ebv principal oncoprotein, latent membrane protein 1 (lmp1). in addition, irf7 was ma ... | 2017 | 28712115 |
| clinical usefulness of f-18 fdg pet in lymphoepithelioma-like gastric carcinoma. | lymphoepithelioma-like carcinoma (lelc) is a rare type of gastric cancer. we evaluated the clinical usefulness of f-18 fdg positron emission tomography/computed tomography (pet/ct) in lelc of stomach. | 2017 | 28712702 |
| nutlin-3, a p53-mdm2 antagonist for nasopharyngeal carcinoma treatment. | nasopharyngeal carcinoma (npc) is a form of head and neck cancer of multifactorial etiologies that is highly prevalent among men in the populations of southern china and southeast asia. npc has claimed many thousands of lives worldwide; but the low awareness of npc remains a hindrance in early diagnosis and prevention of the disease. npc is highly responsive to radiotherapy and chemotherapy, but radiocurable npc is still dependent on concurrent treatment of megavoltage radiotherapy with chemothe ... | 2017 | 28714398 |
| small molecule perturbation of the cand1-cullin1-ubiquitin cycle stabilizes p53 and triggers epstein-barr virus reactivation. | the chemical probe c60 efficiently triggers epstein-barr virus (ebv) reactivation from latency through an unknown mechanism. here, we identify the cullin exchange factor cand1 as a biochemical target of c60. we also identified cand1 in an shrna library screen for ebv lytic reactivation. gene expression profiling revealed that c60 activates the p53 pathway and protein analysis revealed a strong stabilization and s15 phosphorylation of p53. c60 reduced cullin1 association with cand1 and led to a g ... | 2017 | 28715492 |
| quantitation of dna methylation in epstein-barr virus-associated nasopharyngeal carcinoma by bisulfite amplicon sequencing. | epigenetic changes, including dna methylation, disrupt normal cell function, thus contributing to multiple steps of carcinogenesis. nasopharyngeal carcinoma (npc) is endemic in southern china and is highly associated with epstein-barr virus (ebv) infection. significant changes of the host cell methylome are observed in ebv-associated npc with cancer development. epigenetic marks for npc diagnosis are urgently needed. in order to explore dna methylation marks, we investigated dna methylation of c ... | 2017 | 28716111 |
| methotrexate-associated lymphoproliferative disorder in a patient with neuromyelitis optica spectrum disorder: an implication for pathogenesis mediated by epstein-barr virus. | 2017 | 28716244 | |
| a prospective study of infectious mononucleosis in college students. | the present study aims to prospectively investigate possible biological and psychological factors present in college students who will go on to develop chronic fatigue syndrome (cfs) following infectious mononucleosis (im). identification of risk factors predisposing patients towards developing cfs may help to understand the underlying mechanisms and ultimately prevent its occurrence. our study is enrolling healthy college students over the age of 18. enrollment began in march of 2013 and is ong ... | 2017 | 28717787 |
| frequency of epstein-barr virus in classical hodgkin lymphoma. | epstein-barr virus plays an important role in pathogenesis of hodgkin lymphoma. the first patient with epstein-barr positive reed sternberg cells was described in 1985. since then association between epstein-barr virus and hodgkin lymphoma has been shown in many parts of the world and its occurrence shows significant variation from continent to continent and from country to country. | 2017 | 28718560 |
| clinical utility of epstein-barr virus dna testing in the treatment of nasopharyngeal carcinoma patients. | epstein-barr virus (ebv) dna analysis has been shown to be useful for early detection, prognostication, and monitoring of treatment response of nasopharyngeal carcinoma (npc), and the recent literature provides growing evidence of the clinical utility of ebv dna testing, particularly to inform treatment decisions for npc patients. despite the fact that npc is a rare disease, the nrg oncology cooperative group has successfully activated a phase 2/3 randomized clinical trial for npc with internati ... | 2017 | 28721913 |
| monoamine oxidase a is highly expressed in classical hodgkin lymphoma. | monoamine oxidase a (maoa) is a mitochondrial enzyme that catalyzes oxidative deamination of neurotransmitters and dietary amines and produces h2 o2. it facilitates the progression of gliomas and prostate cancer, but its expression and functional relevance have not been studied in lymphoma. here, we evaluated maoa in 427 cases of hodgkin and non-hodgkin lymphoma and in a spectrum of reactive lymphoid tissues by immunohistochemistry on formalin-fixed paraffin-embedded specimens. maoa was expresse ... | 2017 | 28722111 |
| oral shedding of herpesviruses in hiv+ patients with varying degrees of immune status. | herpesvirus shedding in the oral cavity was analyzed to determine if presence in the oral compartment correlates with systemic changes in hiv-associated immune deficiency as measured by cd4+ counts, plasma hiv viral load (vl) and presence of aids-defining events. | 2017 | 28723706 |
| subclinical herpesvirus shedding among hiv-1-infected men on antiretroviral therapy. | we evaluated the subclinical shedding of 6 different herpesviruses in antiretroviral drug-treated hiv(+) men who have sex with men (msm), and determined how this is associated with markers of inflammation and immune activation. | 2017 | 28723708 |
| translesion polymerase, pol η, is required for efficient epstein-barr virus infectivity and is regulated by the viral deubiquitinating enzyme, bplf1. | epstein-barr virus (ebv) infection and lytic replication are known to induce a cellular dna damage response. previously we showed that the virally encoded bplf1 protein interacts with and regulates several members of the translesion synthesis pathway (tls), a dna damage tolerance pathway, and that these cellular factors enhance viral infectivity. bplf1 is a late lytic cycle gene, but the protein is also packaged in the viral tegument indicating that bplf1 may function both early and late during ... | 2017 | 28724765 |
| viral driven epigenetic events alter the expression of cancer-related genes in epstein-barr-virus naturally infected burkitt lymphoma cell lines. | epstein-barr virus (ebv) was identified as the first human virus to be associated with a human malignancy, burkitt's lymphoma (bl), a pediatric cancer endemic in sub-saharan africa. the exact mechanism of how ebv contributes to the process of lymphomagenesis is not fully understood. recent studies have highlighted a genetic difference between endemic (ebv+) and sporadic (ebv-) bl, with the endemic variant showing a lower somatic mutation load, which suggests the involvement of an alternative vir ... | 2017 | 28724958 |
| epstein-barr virus (ebv)-associated epithelial and non-epithelial lesions of the oral cavity. | epstein-barr virus (ebv) is known to be associated with the development of malignant lymphoma and lymphoproliferative disorders (lpds) in immunocompromised patients. ebv, a b-lymphotropic gamma-herpesvirus, causes infectious mononucleosis and oral hairy leukoplakia, as well as various pathological types of lymphoid malignancy. furthermore, ebv is associated with epithelial malignancies such as nasopharyngeal carcinoma (npc), salivary gland tumor, gastric carcinoma and breast carcinoma. in terms ... | 2017 | 28725300 |
| approaches to controlled co-amplification of genes for production of biopharmaceuticals: study of the insertion and amplification dynamics of genetic cassettes in the genome of chinese hamster ovary cells during co-expression of compatible pair of plasmids. | plasmid vector family p1.1 based on non-coding regions of chinese hamster housekeeping gene eef1a and concatemer of epstein-barr virus terminal repeat increases the frequency of genome integration and provides rapid amplification of the target genes in the genome. for a pair of fluorescent proteins egfp and mcherry it was shown that p1.1 vectors bearing dihydrofolate reductase and glutamine synthetase selection markers upon co-transfection into cho dg44 cell line allow obtaining a polyclonal cel ... | 2017 | 28726207 |
| p53 deregulation in epstein-barr virus-associated gastric cancer. | tp53 is a tumour suppressor gene frequently mutated in human cancers; nevertheless, in ebv-associated malignancies mutations are uncommon despite frequent deregulation of the p53 pathway. in this study, we aimed to investigate p53 expression, tp53 mrna levels and tp53 mutations in ebv-associated gastric carcinoma (ebvagc). a case-control study was performed using 46 patients: 15 ebvagc and 31 ebv-negative gc (ebvngc) cases. p53 expression was detected by immunohistochemistry (ihc), the evaluatio ... | 2017 | 28729047 |
| the epstein-barr virus brrf1 gene is dispensable for viral replication in hek293 cells and transformation. | the epstein-barr virus (ebv) is a gamma-herpesvirus associated with several malignancies. it establishes a latent infection in b lymphocytes and is occasionally reactivated to enter the lytic cycle. here we examined the role of the ebv gene brrf1, which is expressed in the lytic state. we first confirmed, using a dna polymerase inhibitor, that the brrf1 gene is expressed with early kinetics. a brrf1-deficient recombinant virus was constructed using a bacterial artificial chromosome system. no ob ... | 2017 | 28729695 |
| exposure to the epstein-barr viral antigen latent membrane protein 1 induces myelin-reactive antibodies in vivo. | multiple sclerosis (ms) is an autoimmune chronic inflammatory disease of the central nervous system (cns). cross-reactivity of neuronal proteins with exogenous antigens is considered one of the possible mechanisms of ms triggering. previously, we showed that monoclonal myelin basic protein (mbp)-specific antibodies from ms patients cross-react with epstein-barr virus (ebv) latent membrane protein 1 (lmp1). in this study, we report that exposure of mice to lmp1 results in induction of myelin-reac ... | 2017 | 28729867 |
| role of epstein-barr virus in the development of nasopharyngeal carcinoma. | southern china experiences larger extent of total cancer pathologies, of which nasopharyngeal carcinoma has the highest incidence under otorhinolaryngeal malignant carcinomas. risk factor of nasopharyngeal carcinoma varies from hereditary causes to virus infection, among which epstein-barr virus (ebv) infection is the mostly investigated. the study into mechanism of ebv in occurrence, development and prognosis of nasopharyngeal carcinoma has been studied for several decades. the pathophysiology ... | 2017 | 28730175 |
| exploring the effect of vitamin d3 supplementation on the anti-ebv antibody response in relapsing-remitting multiple sclerosis. | epstein-barr virus (ebv) infection and vitamin d insufficiency are potentially interacting risk factors for multiple sclerosis (ms). | 2017 | 28731372 |
| lmp1-mediated glycolysis induces myeloid-derived suppressor cell expansion in nasopharyngeal carcinoma. | myeloid-derived suppressor cells (mdscs) are expanded in tumor microenvironments, including that of epstein-barr virus (ebv)-associated nasopharyngeal carcinoma (npc). the link between mdsc expansion and ebv infection in npc is unclear. here, we show that ebv latent membrane protein 1 (lmp1) promotes mdsc expansion in the tumor microenvironment by promoting extra-mitochondrial glycolysis in malignant cells, which is a scenario for immune escape initially suggested by the frequent, concomitant de ... | 2017 | 28732079 |
| association of clinical and serological parameters of systemic lupus erythematosus patients with epstein-barr virus antibody profile. | epstein-barr viral infection is one of the known environmental factors involved in development of systemic lupus erythematous (sle). though not much is known about the exact role of ebv in sle pathogenesis, the theory of switching of lytic and lysogenic cycles of epstein-barr virus in memory b-cells fits well with the periods of waning disease activity and intermittent flares in sle patients. in this study, we investigate the association of ebv antibody profile with clinical and serological para ... | 2017 | 28734074 |
| rps27a enhances ebv-encoded lmp1-mediated proliferation and invasion by stabilizing of lmp1. | epstein-barr virus (ebv)-encoded latent membrane protein 1 (lmp1) is an oncoviral protein that plays a pivotal role in ebv-induced oncogenic transformation. the function of lmp1 in ebv-induced oncogenesis has been well studied. however, the molecular mechanisms underlying lmp1 protein stability remain poorly understood. in this study, we found that ribosomal protein s27a (rps27a) regulates lmp1 stability by a tandem affinity purification analysis. rps27a interacts directly with lmp1 in vitro and ... | 2017 | 28735865 |
| cytokine expression associated with helicobacter pylori and epstein-barr virus infection in gastric carcinogenesis. | helicobacter pylori and epstein-barr virus (ebv) infection, and associated cytokines are involved in gastric carcinogenesis. we investigated the expression of these cytokines and their relationship with clinicopathological characteristics. the study included specimens from 207 patients with gastric adenocarcinoma, 56 with chronic gastritis, 32 with metaplasia, and 30 with low-grade epithelial dysplasia. tissue microarrays were constructed and immunohistochemical staining for il-1β, il-6, il-10, ... | 2017 | 28736845 |
| distinct oxysterol requirements for positioning naïve and activated dendritic cells in the spleen. | correct positioning of dendritic cells (dcs) is critical for efficient pathogen encounter and antigen presentation. epstein-barr virus-induced gene 2 (ebi2) has been identified as a chemoattractant receptor required for naïve cd4(+)dcir2(+) dc positioning in response to 7α,25-hydroxycholesterol (7α,25-hc). we now provide evidence that a second ebi2 ligand, 7α,27-hc, is involved in splenic dcir2(+) dc positioning and homeostasis. cyp27a1, the enzyme uniquely required for 7α,27-hc synthesis, is ex ... | 2017 | 28738017 |
| ebv-hlh children with reductions in cd4+ t cells and excessive activation of cd8+ t cells. | backgroundin this report, we analyzed the number and activation profiles of t cells in epstein-barr virus-associated hemophagocytic lymphohistiocytosis (ebv-hlh) patients and assessed their value for the diagnosis of ebv-hlh.methodswe compared the quantity of cd4+ t cells and cd8+ t cells in peripheral blood among hlh patients, a sepsis group, and healthy controls. we then analyzed variations in the activation marker in cd4+ t and cd8+ t cells.resultsthe percentage of cd4+ t cells decreased in t ... | 2017 | 28738028 |
| collision of lymphoepithelioma-like carcinoma with diffuse large b-cell lymphoma of the stomach: a case report. | collision of epstein-barr virus (ebv)-associated lymphoepithelioma-like carcinoma (lelc) with non-hodgkin's lymphoma of the stomach is extremely rare. | 2017 | 28739754 |
| evaluation of antigen-specific igm and igg production during an in vitro peripheral blood mononuclear cell culture assay. | the recent attention given to diseases associated with memory b-cell (mbc)-produced antibodies (abs) suggests the need for a similar in vitro assay to evaluate the functions of mbcs. here, we cultured peripheral blood mononuclear cells (pbmcs) with the intent to collect mbc-derived abs in vitro and maintain their cell-cell contact-dependent interactions with helper t-cells. pbmcs were cultured with interleukin (il)-21, cpg-oligodeoxynucleotides (odn), phorbol myristate acetate (pma), and phytohe ... | 2017 | 28740496 |
| dna oncogenic virus-induced oxidative stress, genomic damage, and aberrant epigenetic alterations. | approximately 20% of human cancers is attributable to dna oncogenic viruses such as human papillomavirus (hpv), hepatitis b virus (hbv), and epstein-barr virus (ebv). unrepaired dna damage is the most common and overlapping feature of these dna oncogenic viruses and a source of genomic instability and tumour development. sustained dna damage results from unceasing production of reactive oxygen species and activation of inflammasome cascades that trigger genomic changes and increased propensity o ... | 2017 | 28740569 |
| a b cell-driven autoimmune pathway leading to pathological hallmarks of progressive multiple sclerosis in the marmoset experimental autoimmune encephalomyelitis model. | the absence of pathological hallmarks of progressive multiple sclerosis (ms) in commonly used rodent models of experimental autoimmune encephalomyelitis (eae) hinders the development of adequate treatments for progressive disease. work reviewed here shows that such hallmarks are present in the eae model in marmoset monkeys (callithrix jacchus). the minimal requirement for induction of progressive ms pathology is immunization with a synthetic peptide representing residues 34-56 from human myelin ... | 2017 | 28744286 |
| epstein-barr virus positivity is associated with angiogenesis in, and poorer survival of, patients receiving standard treatment for classical hodgkin's lymphoma. | epstein-barr virus (ebv) is a significant contributor to the development of classical hodgkin's lymphoma (chl). recent studies have documented associations between angiogenesis and ebv-associated malignancies. no study has yet examined the associations among, and prognostic implications of, ebv infection, vascular endothelial growth factor (vegf) expression, and microvessel density (mvd) in chl patients. diagnostic tissues from 135 chl patients treated with adriamycin, bleomycin, vinblastine, an ... | 2017 | 28744882 |
| acute epstein-barr virus encephalitis in an immunocompetent adolescent patient. | 2017 | 28746439 | |
| clinical significance of four molecular subtypes of gastric cancer identified by the cancer genome atlas project. | purpose: the cancer genome atlas (tcga) project recently uncovered four molecular subtypes of gastric cancer: epstein-barr virus (ebv), microsatellite instability (msi), genomically stable (gs), and chromosomal instability (cin). however, their clinical significances are currently unknown. we aimed to investigate the relationship between subtypes and prognosis of patients with gastric cancer.experimental design: gene expression data from a tcga cohort (n = 262) were used to develop a subtype pre ... | 2017 | 28747339 |
| erratum: defective t-cell control of epstein-barr virus infection in multiple sclerosis. | [this corrects the article doi: 10.1038/cti.2016.87.]. | 2017 | 28748090 |
| extranodal nk/t-cell lymphoma, nasal type, presenting as refractory pseudomonas aeruginosa facial cellulitis. | extranodal natural killer t-cell lymphoma, nasal type (enkl), formerly called lethal midline granuloma or angiocentric t-cell lymphoma, is a predominantly extranodal non-hodgkin lymphoma characterized by vascular damage, necrosis, and an association with epstein-barr virus. in the united states, it is more frequently seen in asian, asian pacific islander, and hispanic descent populations and is more prevalent in males in their fifth decade. clinical presentation of nk nasal lymphoma most commonl ... | 2017 | 28748192 |
| oral bexarotene for post-transplant cutaneous t-cell lymphoma. | organ transplant recipients receiving immunosuppression have an increased risk of developing post-transplant lymphoproliferative diseases (ptlds). traditionally, ptlds refer to epstein-barr virus (ebv)-induced b-cell lymphoma. however, post-transplant t-cell lymphoma may also occur and tends to have a poorer response to reduced immunosuppressive therapy. as such, additional therapy is often needed for post-transplant t-cell lymphoma, including post-transplant cutaneous t-cell lymphoma (pt-ctcl). ... | 2017 | 28748653 |
| epstein-barr virus-positive ileal carcinomas associated with crohn's disease. | 2017 | 28752215 | |
| successful treatment with anti-programmed-death-1 antibody in a relapsed natural killer/t-cell lymphoma patient with multi-line resistance: a case report. | extranodal natural killer/t-cell lymphoma (nktcl), nasal type, is an aggressive malignancy with poor prognosis. currently, there is no recommended standard therapy for relapsed nktcl. | 2017 | 28754096 |
| multiparametric detection of antibodies against different ebv antigens to predict risk for nasopharyngeal carcinoma in a high-risk population of china. | in this study, we aimed to use the combined detection of multiple antibodies against epstein-barr virus (ebv) antigens to develop a model for screening and diagnosis of nasopharyngeal carcinoma (npc). samples of 300 nasopharyngeal carcinoma patients and 494 controls, including 294 healthy subjects (hc), 99 non-nasopharyngeal carcinoma cancer patients (nnpc), and 101 patients with benign nasopharyngeal lesions (bnl), were incubated with the euroline anti-ebv profile 2, and band intensities were u ... | 2017 | 28754665 |
| ebv and ms: major cause, minor contribution or red-herring? | multiple sclerosis (ms) is a chronic neurological disease with genetic and environmental risk factors. epstein barr-virus (ebv) has been closely associated with ms but with a significant amount of conflicting evidence. some of the evidence for ebv involvement in ms includes: almost 100% of ms patients showing past ebv infection, an association with infectious mononucleosis (acute ebv infection), higher titres of ebv antibodies associated with an increased risk of ms development, and an overall a ... | 2017 | 28755681 |
| epstein-barr virus and multiple sclerosis: updating pender's hypothesis. | substantial epidemiological evidence supports the involvement of the epstein-barr virus (ebv) in multiple sclerosis (ms). mechanisms through which ebv may increase ms risk are reviewed here. most individuals contract ebv in early childhood yet only develop ms in early adulthood, by which time ebv has been latent for decades. when latent, ebv is confined to a minute subset of memory b cells: about 1000 cells in peripheral blood and 500,000 cells in the lymphoid system, mainly in the mouth. reacti ... | 2017 | 28755684 |
| concomitant epstein-barr virus-associated smooth muscle tumor and granulomatous inflammation of the liver. | epstein-barr virus-associated smooth muscle tumor (ebv-smt) is a rare mesenchymal tumor typically seen in immunocompromised patients. here, we report a case of ebv-smt and associated granulomatous inflammation in the liver of a 32-year-old man with history of human immunodeficiency virus/acquired immune deficiency syndrome (hiv/aids). to our knowledge, an association of these two lesions has not been previously reported. we review the literature and discuss pathogenesis, differential diagnosis a ... | 2017 | 28756985 |
| the role of epigenetic regulation in epstein-barr virus-associated gastric cancer. | the epstein-barr virus (ebv) is detected in about 10% of gastric carcinoma cases throughout the world. in ebv-associated gastric carcinoma (ebvagc), all tumor cells harbor the clonal ebv genome. the expression of latent ebv genes is strictly regulated through the methylation of ebv dna. the methylation of viral dna regulates the type of ebv latency, and methylation of the tumor suppressor genes is a key abnormality in ebvagc. the methylation frequencies of several tumor suppressor genes and cell ... | 2017 | 28757548 |
| antibodies against the mono-methylated arginine-glycine repeat (mma-rg) of the epstein-barr virus nuclear antigen 2 (ebna2) identify potential cellular proteins targeted in viral transformation. | the epstein-barr virus is a human herpes virus with oncogenic potential. the virus-encoded nuclear antigen 2 (ebna2) is a key mediator of viral tumorigenesis. ebna2 features an arginine-glycine (rg) repeat at amino acids (aa)339-354 that is essential for the transformation of lymphocytes and contains symmetrically (sdma) and asymmetrically (adma) di-methylated arginine residues. the sdma-modified ebna2 binds the survival motor neuron protein (smn), thus mimicking smd3, a cellular sdma-containing ... | 2017 | 28758620 |
| lymphoproliferative disorders in patients with rheumatoid arthritis in the era of widespread use of methotrexate: a review of the literature and current perspective. | lymphoproliferative disorders (lpd) in patients receiving methotrexate (mtx) have gained strong attention. in this article, i reviewed the basic and clinical findings of this issue. patients with ra possess a high risk of lymphoma, but epidemiological evidence showing an association between the use of mtx and lymphoma is still limited. rapid regression of lpd after stopping mtx in patients with ra strongly suggests that there is a causative relationship. genetic predisposition, accumulated infla ... | 2017 | 28758827 |
| henoch-schonlein purpura associated with primary active epstein-barr virus infection: a case report. | henoch-schönlein purpura (hsp) is the most common form of childhood vasculitis. various viral and bacterial infections, drugs, vaccines, food allergy and even insect bites have been considered as triggering factors in pathogenesis of hsp. epstein-barr virus (ebv) infection, which is associated with hsp, have been rarely reported. herein we present hsp patient possibly caused by ebv infection. a 8-year old boy was admitted to our department with fever, rashes on legs and arms and intermittent mil ... | 2017 | 28761605 |
| [ebv-positive central nervous system lymphoproliferative disease associated with immunosuppression after organ transplantation: long-term remission without chemotherapy]. | primary central nervous system (cns) lymphomas account for 13-20% of the posttransplant lymphoproliferative disorders (ptld) and rank among the most aggressive conditions. reduction of immunosuppressive therapy should be mandatory to treat ptld, but this is rarely used as the only therapy option. chemotherapy regimens for ptld involving the cns most commonly include high-dose rituximab and high-dose methotrexate and/or cytarabine. the efficiency only of discontinuation of immunosuppressive thera ... | 2017 | 28766544 |
| cutaneous intravascular natural killer/t cell lymphoma with peculiar immunophenotype. | intravascular lymphoma (ivl) is a rare entity. most cases are a variant of extranodal diffuse large b cell lymphoma, and fewer than 10% of the published cases are of t cell origin. only intravascular b cell lymphoma is recognized as a distinct entity in the most recent world health organization (who) classification of lymphoproliferative disorders. we describe a case of cutaneous natural killer (nk)/t ivl, with a cytotoxic immunophenotype and epstein-barr virus (ebv) positivity. however, our cas ... | 2017 | 28766736 |
| programmed death 1 is highly expressed on cd8+cd57+ t cells in patients with stable multiple sclerosis and inhibits their cytotoxic response to ebv. | growing evidence points to a deregulated response to epstein-barr virus (ebv) in the cns of patients with multiple sclerosis (pwms) as a possible cause of disease. in this study, we have investigated the response of a subpopulation of effector cd8+ t cells to ebv in 36 healthy donors and in 35 pwms in active and inactive disease. we have measured the expression of markers of degranulation, the release of cytokines, cytotoxicity and the regulation of effector functions by inhibitory receptors, su ... | 2017 | 28767147 |
| probable acute epstein-barr virus encephalitis in a 6-year-old girl. | 2017 | 28767164 | |
| small intestine follicular dendritic cell sarcoma with liver metastasis: a case report. | follicular dendritic cell sarcoma (fdcs) is a rare neoplasia composed of spindle or oval cells with follicular dendritic cell differentiation, usually occurring in lymphoid tissue. in this report, we present a case of fdcs of the small intestine with liver metastasis. | 2017 | 28767565 |
| herpesviral micrornas in cellular metabolism and immune responses. | the micrornas (mirnas) function as a key regulator in many biological processes through post-transcriptional suppression of messenger rnas. recent advancements have revealed that mirnas are involved in many biological functions of cells. not only host cells, but also some viruses encode mirnas in their genomes. viral mirnas regulate cell proliferation, differentiation, apoptosis, and the cell cycle to establish infection and produce viral progeny. particularly, mirnas encoded by herpes virus fam ... | 2017 | 28769892 |