Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| protein expression profiles of chlamydia pneumoniae in models of persistence versus those of heat shock stress response. | chlamydia pneumoniae is an obligate intracellular pathogen that causes both acute and chronic human disease. several in vitro models of chlamydial persistence have been established to mimic chlamydial persistence in vivo. we determined the expression patterns of 52 c. pneumoniae proteins, representing nine functional subgroups, from the gamma interferon (ifn-gamma) treatment (primarily tryptophan limitation) and iron limitation (il) models of persistence compared to those following heat shock (h ... | 2006 | 16790757 |
| [chlamydophila pneumoniae seroprevalence in adults from the general population]. | chlamydophila pneumoniae is an intracelular pathogen involved in the inflammatory pathogenesis of some chronic diseases with high prevalence. infectivity is supposed to be high because the serologic patterns published are widely spread out all over the world. however, the prevalence in the spanish adult population is unknown. our goal was to assess the seroprevalence of specific igg and iga against c. pneumoniae in the general adult population performing an indirect immunofluorescence assay. | 2006 | 16792979 |
| inflammation and atrial fibrillation: is chlamydia pneumoniae a candidate pathogen of atrial fibrillation? | atrial fibrillation is the most common arrhythmia, however, the mechanism of atrial fibrillation is not well explained. it has been considered that inflammation plays a role in atrial fibrillation, recently. patients undergoing coronary artery bypass graft are at high risk for developing postoperative atrial fibrillation. the peak levels of c-reactive protein (crp) were paralleled to the incidence of postoperative atrial fibrillation. in general population, crp was also higher in patients with a ... | 2006 | 16793213 |
| infection induced inflammation is associated with erectile dysfunction in men with diabetes. | in diabetic patients with erectile dysfunction, endothelial dysfunction is a major underlying cause. infection-induced inflammation may be associated with endothelial dysfunction. the goal of this study was to determine whether erectile dysfunction in patients with diabetes is associated with infections of chlamydia pneumoniae or cytomegalovirus and/or with low-grade inflammation. | 2006 | 16796607 |
| identification and characterization of secreted effector proteins of chlamydophila pneumoniae tw183. | we report the expression of several chlamydial effector proteins in chlamydophila pneumoniae, as well as their time-dependent secretion into the inclusion membrane. localization of the respective genes within type iii secretion gene clusters as well as bioinformatic analysis suggest that the identified proteins are type iii-secreted effector proteins. immunocytochemistry with antisera raised against cpmip (c. pneumoniae macrophage infectivity potentiator, cpn0661), pkn5 (cpn0703), cpn0709, cpn07 ... | 2006 | 16797933 |
| association of chlamydia pneumoniae infection and carotid intima-media wall thickness in japanese americans. | chlamydia pneumoniae (cp) infection has been proposed as a risk factor for coronary artery disease (cad), but it remains unclear whether cp plays a role in the progression of early stage carotid atherosclerosis. | 2006 | 16799231 |
| [etiology and prognostics factors of community-acquired pneumonia among adults patients admitted to a regional hospital in chile]. | community-acquired pneumonia (cap) is a common and serious illness in chile. | 2006 | 16802052 |
| antimicrobial therapy in childhood asthma and wheezing. | there is an increasing number of viral and bacterial pathogens suspected of contributing to asthma pathogenesis in childhood, making it more difficult for the practitioner to make specific therapy decisions. this review discusses the role of viruses, e.g. respiratory syncytial virus, human metapneumovirus, influenza viruses and rhinoviruses, as well as the role of the atypical bacteria chlamydophila pneumoniae and mycoplasma pneumoniae, as contributors to childhood asthma. diagnosis, prevention, ... | 2006 | 16808545 |
| [morphological aspects of atherosclerosis lesion: past and present]. | atherosclerosis is an inflammatory process disease that involves the artery wall and that is characterized by the progressive accumulation of lipids. the term arteriosclerosis has been created by lobstein in 1833. subsequently, during the 19th century, the contribution of rokitansky and virchow was important to elucidate the pathogenesis of arteriosclerosis and the morphologic aspects of the plaque. in the beginning of the 20th century, aschoff was a leading proponent who regarded the morphologi ... | 2006 | 16817503 |
| chlamydia trachomatis-derived deubiquitinating enzymes in mammalian cells during infection. | chlamydia trachomatis is an obligate intracellular bacterium that causes a variety of diseases in humans. c. trachomatis has a complex developmental cycle that depends on host cells for replication, during which gene expression is tightly regulated. here we identify two c. trachomatis proteases that possess deubiquitinating and deneddylating activities. we have designated these proteins chladub1 and chladub2. the genes encoding chladub1 and chladub2 are present in all chlamydia species except fo ... | 2006 | 16824101 |
| reaching out for the causative agent in inflammatory bowel disease: is there evidence for chlamydia pneumoniae as a pathogenic factor? | in this issue of the journal, muller and colleagues attempt to define the role of specific bacterial pathogens, particularly chlamydia pneumoniae, as causative agents in inflammatory bowel disease. even if a major role for c. pneumoniae in the pathogenesis of inflammatory bowel disease could be ruled out, our current understanding of inflammatory pathways in crohn's disease and ulcerative colitis implies that the search for other microorganisms as causative agents should continue. | 2006 | 16825905 |
| serological and dna-based evaluation of chlamydia pneumoniae infection in inflammatory bowel disease. | chlamydia has been associated with autoimmune diseases, but a link between chlamydial infection and the aetiopathogenesis of inflammatory bowel disease (ibd) remains controversial. in this study we assessed the relationship between chlamydial infection and ibd, as evidenced by serological measurement and dna analysis of mucosal biopsy specimens. | 2006 | 16825908 |
| prevalence of chlamydophila pneumoniae among bangladeshi children under age 5 years with acute respiratory infections. | despite major improvements in the diagnosis of pathogenic organisms causing acute respiratory infections (aris), details of infections caused by atypical pathogens are not well understood, particularly in developing countries. this clinical and epidemiological research was conducted in bangladesh to explore the prevalence of atypical pathogens in causing childhood pneumonia. sixty-four children with ari were studied at the pediatric outpatient department of dhaka medical college hospital, bangla ... | 2006 | 16826346 |
| prior exposure to infection with chlamydia pneumoniae can influence the t-cell-mediated response to chlamydia trachomatis. | using t-cell clones derived from patients with chlamydia trachomatis (ct)-induced reactive arthritis, we identified target antigens and mapped the peptide epitopes that were recognized. several epitopes were conserved in homologous proteins of chlamydia pneumoniae (cpn), and it was shown that these epitopes were generated following processing of the cpn proteins or cpn elementary bodies, i.e. the t-cell clones were indeed ct and cpn cross-reactive. given that cpn infection is frequent, we wished ... | 2006 | 16831205 |
| chlamydia (chlamydophila) pneumoniae-induced cell death in human coronary artery endothelial cells is caspase-independent and accompanied by subcellular translocations of bax and apoptosis-inducing factor. | atherosclerosis and coronary heart disease are causing high morbidity and mortality worldwide. different risk factors have been demonstrated, but the exact mechanisms behind these diseases are still not fully understood. recent studies have suggested chlamydia pneumoniae to be involved in the pathogenesis, and increased apoptotic indexes in atherosclerotic plaques have been documented. in this study, we show that c. pneumoniae induces apoptosis and necrosis in populations of human coronary arter ... | 2006 | 16831207 |
| periodontopathogenic bacteria multiply in the environmental amoeba acanthamoeba castellani. | porphyromonas gingivalis and prevotella intermedia are obligate anaerobe gram-negative periodontopathogenic bacteria. free-living amoebae, such as acanthamoeba spp., are well known as environmental hosts of several human pathogens, such as franciscella tularensis, chlamydia pneumoniae, legionella pneumophila and mycobacteria spp. this study tested the ability of p. gingivalis and p. intermedia to become internalized, to survive and replicate in acanthamoeba castellani. our results show for the f ... | 2006 | 16837243 |
| inflammation, heat shock proteins and periodontal pathogens in atherosclerosis: an immunohistologic study. | inflammation is a significant component of atherosclerosis lesions. bacteria, including periodontopathogens, have been demonstrated in atherosclerotic plaques and cross-reactivity of the immune response to bacterial groel with human heat shock protein 60 has been suggested as a link between infections and atherosclerosis. | 2006 | 16842503 |
| chlamydia pneumoniae and coronary artery disease: controversial results of serological studies. | i have read with great interest the article published by carratelli et al. briefly they have reported increased levels of inflammatory markers and elevated titers of igg and iga of c. pneumoniae by using both elisa and mif method. there are several factors which may underly the controversial results of seroepidemiological studies. i have commented on the report of carratelli et al. regarding some of these factors. | 2006 | 16846847 |
| increased prostanoid dependency of arterial relaxation in chlamydia pneumoniae-infected mice. | endothelial dysfunction plays an important role in the development of atherosclerosis. previous studies have shown that inoculation with chlamydia pneumoniae contributes to atherosclerotic development in rabbits and hypercholesterolaemic mice and causes endothelial dysfunction in apolipoprotein e-deficient mice. the effect of acute c. pneumoniae infection on endothelial function in normocholesterolaemic c57bl/6j mice was studied by measuring the force of contraction of the descending aorta after ... | 2006 | 16849721 |
| perfluorocarbons decrease chlamydophila pneumoniae-mediated inflammatory responses of rat type ii pneumocytes in vitro. | chlamydophila pneumoniae alter the expression of toll-like receptor (tlr) 4 in alveolar type ii (atii)-cells. subsequently nuclear factor kappab (nf-kappab) is activated and tumor necrosis factor-alpha (tnf-alpha) and macrophage inflammatory protein 2 (mip-2) are produced. perfluorocarbons (pfc) are beneficial in animals with bacterial pneumonia and reduce production of tnf-alpha. using isolated atii-cells, it was studied whether pfc prevent c. pneumoniae-induced tnf-alpha and mip-2 release and ... | 2006 | 16857767 |
| endothelial function parameters in patients with unstable angina and infection with helicobacter pylori and chlamydia pneumoniae. | endothelial dysfunction may be a factor linking infection with atherosclerosis. the aim of our study was to assess the relationship between seropositivity to helicobacter pylori (hp) and/or to chlamydia pneumoniae (cp) and some endothelial function parameters in patients with unstable angina. | 2006 | 16864009 |
| chlamydophila pneumoniae in chronic rhinosinusitis. | the intracellular bacterium chlamydophila pneumoniae (cp) was infrequently found in nasopharynx and lacking in biopsies from the middle turbinate in chronic rhinosinusitis (crs) patients. compared with healthy controls, patients suffering from crs had significantly higher and more prevalent antibody titers to cp. however, an association between crs and cp could not be established. | 2006 | 16864493 |
| secondary outcomes of a pilot randomized trial of azithromycin treatment for asthma. | the respiratory pathogen chlamydia pneumoniae (c. pneumoniae) produces acute and chronic lung infections and is associated with asthma. evidence for effectiveness of antichlamydial antibiotics in asthma is limited. the primary objective of this pilot study was to investigate the feasibility of performing an asthma clinical trial in practice settings where most asthma is encountered and managed. the secondary objectives were to investigate (1) whether azithromycin treatment would affect any asthm ... | 2006 | 16871333 |
| metabolic syndrome, c-reactive protein, and prognosis in patients with established coronary artery disease. | the prognosis associated with metabolic syndrome and high-sensitivity c-reactive protein (hs-crp) in patients with stable coronary artery disease has not been well established. | 2006 | 16875914 |
| is periodontal infection behind the failure of antibiotics to prevent coronary events? | the use of antimicrobial agents to prevent coronary events is under debate. they have reduced cardiovascular events in some studies, but in others, their effect has not been distinguishable from that of placebo. in addition to chlamydophila (chlamydia) pneumoniae as a target pathogen, very few other microbes or infections have been targeted, although an association for instance between cardiovascular disease and periodontitis has been established. in our recent pilot study, long-term clarithromy ... | 2007 | 16876173 |
| levels of antibodies to microorganisms implicated in atherosclerosis and of c-reactive protein among atomic bomb survivors. | although it has been suggested that cardiovascular disease incidence is increased among atomic bomb survivors, the existence of a causal relationship between radiation exposure and atherosclerosis is unclear. microbial infections, including those caused by chlamydia pneumoniae, helicobacter pylori and cytomegalovirus, have recently been implicated in atherosclerosis. since immune function is somewhat impaired among atomic bomb survivors, their immune defense against such infections might be dimi ... | 2006 | 16881737 |
| adult calcific aortic stenosis and chlamydia pneumoniae: the role of chlamydia infection in valvular calcification. | adult calcific aortic stenosis is a well-known clinical entity but its pathophysiology and cellular mechanism have yet to be defined. | 2006 | 16889160 |
| low prevalence of chlamydia pneumoniae in adults with community-acquired pneumonia. | the incidence of community-acquired pneumonia (cap) due to chlamydia pneumoniae was determined in a prospective study of 546 adult patients with cap included in the german cap competence network (capnetz) project. three different pcr protocols for detection of c. pneumoniae in respiratory specimens were compared by a multicenter, inter-laboratory comparison involving three laboratories. a case was defined as a patient with a respiratory sample positive by pcr in at least two laboratories. cap wa ... | 2006 | 16890487 |
| atypical pathogens as etiologic agents in hospitalized patients with community-acquired pneumonia in korea: a prospective multi-center study. | local epidemiologic data on the etiologies of patients hospitalized with community-acquired pneumonia (cap) is needed to develop guidelines for clinical practice. this study was conducted prospectively to determine the proportion of atypical bacterial pathogens in adults patients hospitalized with cap in korea between october 2001 and december 2002. microbiological diagnosis was determined by serology for antibodies to mycoplasma pneumoniae, chlamydia pneumoniae, and legionella pneumophila. nucl ... | 2006 | 16891800 |
| detection by broad-range real-time pcr assay of chlamydia species infecting human and animals. | tests available for molecular diagnosis of chlamydial infections detect chlamydiatrachomatis, but do not find other chlamydia species associated with genital, ophthalmic, cardiovascular, respiratory or neurological diseases. the routine detection of all chlamydia species would improve the prognosis of infected people and guide therapeutic choices. | 2006 | 16899531 |
| chlamydia pneumoniae infection and the risk of multiple sclerosis: a meta-analysis. | we conducted a meta-analysis of studies comparing the presence of chlamydia pneumoniae (cpn) between multiple sclerosis (ms) patients and other neurological diseases patients or healthy controls. we identified 26 studies with 1332 ms patients and 1464 controls. using random-effects methods, ms patients were found more likely to have detectable levels of cpn dna (or = 3.216; 95% ci: 1.204, 8.585) in their cerebrospinal fluid, and intrathecally synthesized immunoglobulins (or = 3.842; 95% ci: 1.31 ... | 2006 | 16900753 |
| the possible association of chlamydia pneumoniae infection with nasal polyps. | the objective of this study was to investigate the possible etiologic role of chlamydia pneumoniae infection in nasal polyps. this prospective clinical study was undertaken enrolling 30 patients with nasal polyps, and 30 age and sex-matched control subjects from whom epithelial material was obtained during endoscopic surgery. igg specific elisa was used to determine seropositivity, and indirect immunoflorescence to determine c. pneumoniae in the biopsy material. c. pneumoniae specific igg antibo ... | 2007 | 16902779 |
| recurrent optic neuritis associated with chlamydia pneumoniae infection of the central nervous system. | it has been suggested that chlamydia pneumoniae (c. pneumoniae) is involved in the pathogenesis of diverse diseases of the central nervous system (cns), including multiple sclerosis. we report the case of a 12-year-old male with isolated recurrent optic neuritis and an associated cns infection with c. pneumoniae. the patient presented with three attacks of optic neuritis within 5 months. a positive polymerase chain reaction for c. pneumoniae in the cerebrospinal fluid led to the diagnosis of a c ... | 2006 | 16904026 |
| [infectious agents in the pathogenesis of multiple sclerosis]. | multiple sclerosis (ms) is a chronic demyelinating disease of the central nervous system (cns) of a still unknown etiology. genetic factors, environmental agents and an autoimmune response may play an important role in the pathogenesis of ms. in the paper the current opinion on the role of infectious agents in the pathogenesis of ms is presented. the results of epidemiological and serological studies are discussed as well as the results of viral isolation attempts and the search for virus struct ... | 2006 | 16909795 |
| disseminated invasive aspergillosis in a patient with acute leukaemia. | a 46-year-old previously healthy woman was diagnosed with acute lymphoblastic leukaemia. the induction phase was complicated by alpha-haemolytic streptococcal bacteremia which responded to antibacterial therapy. subsequently, the patient developed pneumonie due to chlamydiapneumoniae which responded to macrolides. following this infection the patient developed recurrent fever and new pulmonary infiltrates were noted. bronchoscopy was performed and treatment was administered with liposomal amphot ... | 2006 | 16918060 |
| [acute generalized exanthematous pustulosis: first case associated with a chlamydia pneumoniae infection]. | skin reactions to drugs or infections can be very important. case report: a 14-year-old boy developed fever, a diffuse pustular rash and a respiratory distress. chest x-rays and serology were consistent with an acute chlamydia pneumoniae infection. a skin biopsy revealed an acute generalized exanthematous pustulosis. conclusion: acute generalized exanthematous pustulosis (agep) is a disease manifested by a diffuse eruption of follicular sterile pustules. most of the cases are drug induced, but t ... | 2006 | 16919427 |
| identification of chlamydia pneumoniae proteins in the transition from reticulate to elementary body formation. | chlamydia pneumoniae is an important human respiratory pathogen that is responsible for an estimated 10% of community-acquired pneumonia and 5% of bronchitis and sinusitis cases. we examined changes in global protein expression profiles associated with the redifferentiation of reticulate body (rb) to elementary body (eb) as c. pneumoniae cells progressed from 24 to 48 h postinfection in hep2 cells. proteins corresponding to those showing the greatest changes in abundance in the beginning of the ... | 2006 | 16921167 |
| [chlamydia pneumoniae in otorhinolaryngological infection]. | i detail clinical observation, examination, and treatment of regional otorhinolaryngological infection 3-cases of acute sinusitis and 1 of acute pharyngitis-due to chlamydia pneumoniae, occurring between january 2002 and december 2004. special clinical features by infection with c. pneumoniae were not recognized in the 4 cases, while ordinary clinical features by conventional bacterial infection were recognized, such as pharyngalgia and pyrexia for acute pharyngitis and purulent discharge and he ... | 2006 | 16922488 |
| association between chlamydia pneumoniae antibodies and wheezing in young children and the influence of sex. | the proposed association between chlamydia pneumoniae (cpn) infection and wheezing needs further clarification. | 2006 | 16928718 |
| multiple inflammatory markers in patients with significant coronary artery disease. | several inflammatory biomarkers are linked to cardiovascular risk. in order to investigate their coexistence and relative responses, several established and two novel markers (lactoferrin and the terminal complement complex), representing infection and central components of inflammation, were measured simultaneously in patients undergoing first-time coronary angiography. | 2007 | 16935369 |
| chlamydophila pneumonia: specific mrna in aorta ascendens in patients undergoing coronary artery by-pass grafting. | the objective of this prospective study was to investigate if chlamydophila pneumoniae (cp)-specific dna and mrna are present in tissue samples from the wall of aorta ascendens in patients undergoing by-pass surgery for coronary artery disease (cad) that includes stable angina pectoris (sap, 25 patients) and acute coronary syndrome (acs, 19 patients). viable cp was detected in 8/44 (18%) patients using reversed transcriptase pcr (rt-pcr) against bacterial mrna with detection of cdna using real-t ... | 2006 | 16938728 |
| systemic and mucosal antibody response in experimental chlamydia pneumoniae infection of mice. | chlamydia pneumoniae is a common human respiratory pathogen, and sera from infected individuals recognize several proteins of c. pneumoniae. we produced c. pneumoniae-specific proteins in a bacillus subtilis expression system. we then used these recombinant c. pneumoniae proteins and purified c. pneumoniae elementary bodies as antigens in enzyme immunoassays to assess the kinetics and protein specificity of the systemic and mucosal antibody responses induced by c. pneumoniae intranasal infection ... | 2006 | 16941954 |
| intranasal administration of chlamydial outer protein n (copn) induces protection against pulmonary chlamydia pneumoniae infection in a mouse model. | chlamydia pneumoniae is an intracellular pathogen that grows inside a vacuole, referred to as an inclusion. c. pneumoniae possess a type iii secretion system (ttss), which allows them to secrete effector molecules into the inclusion membrane and to the host cell cytosol. proteins such as chlamydial outer protein n (copn) that associate with the inclusion membrane are potential targets for the host's mhc-dependent antigen presentation, thereby representing ideal antigen candidates for t cell-base ... | 2007 | 16949182 |
| presence and severity of chlamydia pneumoniae and cytomegalovirus infection in coronary plaques are associated with acute coronary syndromes. | although an association between chlamydia pneumoniae (cpn) or cytomegalovirus (cmv) infection and coronary atherosclerosis has been reported, such an association is less clear for acute coronary syndromes (acs). the purpose of this study was to investigate the pathogenic roles of cpn and cmv infection of coronary plaques in acs. we divided 38 coronary plaque specimens obtained from 38 patients who underwent directional coronary atherectomy or thrombectomy into an acs group (n = 21) and a non-acs ... | 2006 | 16960406 |
| mycobacterium tuberculosis-susceptible i/st mice develop severe disease following infection with taxonomically distant bacteria, salmonella enterica and chlamydia pneumoniae. | mice of i/st strain develop severe lung inflammation and die shortly following infection with virulent mycobacteria. to find out whether tuberculosis (tb)-susceptible i/st mice are susceptible to other intracellular bacteria, we investigated two different taxonomically distant pathogens, chlamydia pneumoniae and salmonella enterica serovar typhimurium. comparison of i/st and tb-resistant a/sn mice (both nramp1(r)) demonstrated that the former are more susceptible to both salmonella and chlamydia ... | 2006 | 16968403 |
| iron enhances endothelial cell activation in response to cytomegalovirus or chlamydia pneumoniae infection. | chronic inflammation has been implemented in the pathogenesis of inflammatory diseases like atherosclerosis. several pathogens like chlamydia pneumoniae (cp) and cytomegalovirus (cmv) result in inflammation and thereby are potentially artherogenic. those infections could trigger endothelial activation, the starting point of the atherogenic inflammatory cascade. considering the role of iron in a wide range of infection processes, the presence of iron may complicate infection-mediated endothelial ... | 2006 | 16968471 |
| chlamydial lipopolysaccharide is present in serum during acute coronary syndrome and correlates with crp levels. | infections, chlamydia pneumoniae as a major candidate, have been suggested to participate in inflammatory processes ultimately leading to atherosclerosis. in the present study we measured serum levels of chlamydial lipopolysaccharide (clps) and highly sensitive c-reactive protein (hscrp) in the acute coronary syndrome (acs) patients (n=145). during acs, both clps and hscrp were elevated and significant correlation (p=0.003, r=0.25) between them was observed. both clps and hscrp levels decreased ... | 2007 | 16978631 |
| chronic fatigue syndrome. | chronic fatigue syndrome (cfs) is thought to have a worldwide prevalence of 0.4-1% with approximately 240,000 patients in the uk. diagnosis is based on clinical criteria and critically depends on exclusion of other physical and psychiatric diseases. studies of pathogenesis have revealed immune system abnormalities and chronic immune activation, dysfunction of the hypothalamic-pituitary-adrenal (hpa) axis, brain abnormalities, evidence of emotional stress (comprising host aspects) and evidence of ... | 2006 | 16978917 |
| infectious agents, inflammation, and growth factors: how do they interact in the progression or stabilization of mild human atherosclerotic lesions? | advanced complicated atherosclerotic lesions have been related to many factors, including inflammation, infectious agents, and growth factors. mycoplasma pneumoniae (mp) and chlamydia pneumoniae (cp), inflammation, and growth factors have been associated with severe atherosclerotic lesions in necropsy material in recent work at our lab. the present study intends to clarify the pathogenesis of atherosclerosis, analyzing which of these elements (macrophages, mp, cp, lymphocytes, and growth factors ... | 2006 | 16983590 |
| nf-kappab and inhibitor of apoptosis proteins are required for apoptosis resistance of epithelial cells persistently infected with chlamydophila pneumoniae. | infection with chlamydophila pneumoniae (cpn) renders host cells resistant to apoptosis induced by a variety of stimuli. while modulation of apoptosis has been extensively studied in cells acutely infected with cpn, very little is known on how persistent chlamydial infection influences host cell survival. here we show that epithelial cells persistently infected with cpn resist apoptosis induced with tnfalpha or staurosporine. cpn induced the activation of nuclear factor kappa b (nf-kappab) and i ... | 2006 | 16984419 |
| initial empiric antimicrobial treatment of chlamydia pneumoniae: a study of 54 cases in the republic of macedonia. | analysis of the adequacy of the initial empiric antimicrobial treatment of patients with acute chlamydia pneumoniae (cp) infection, admitted to the infectious diseases clinic, clinical centre, medical faculty, skopje, republic of macedonia, for community-acquired pneumonia. | 2006 | 16985483 |
| infectious causes of multiple sclerosis. | 2006 | 16987736 | |
| involvement of tnfalpha -308a promoter polymorphism in the development of asthma in children infected with chlamydophila pneumoniae. | several data indicate a connection between chlamydophila pneumoniae infection and asthma. although c. pneumoniae is a common cause of infection, not all infected patients develop asthma. this suggests that certain individuals may be genetically predisposed to the chronic effects of c. pneumoniae infection on airway functions. we investigated the possible modifying effect of different polymorphisms on c. pneumoniae infection and on the susceptibility to asthma in 318 children, among those 144 had ... | 2006 | 16988194 |
| multiple sclerosis: an infectious syndrome involving chlamydophila pneumoniae. | the concept of autoimmune myelinopathy as the primary pathology in multiple sclerosis (ms) is problematic. vasculitis is seen in the ms brain, both within lesions and in adjacent normal-appearing white matter. the first observation in acute relapse is the sudden, orderly death of oligodendrocytes; inflammatory removal of unsupported myelin seems to be a secondary process. an alternative explanation for these findings is that oligodendrocyte infection might trigger an inflammatory response. many ... | 2006 | 16996738 |
| interaction between chlamydia pneumoniae seropositivity, inflammation and risk factors for atherosclerosis in patients with severe coronary stenosis. | to investigate whether chlamydia pneumoniae (cpn) seropositivity in patients with suspected coronary artery disease (cad) (n = 81) is associated with increases in markers of inflammation, the severity of coronary atherosclerosis, and traditional risk factors for cardiovascular events. | 2006 | 17000560 |
| chlamydia and mycoplasma serology in respiratory tract infections of children. | one of the challenges in planning the treatment of respiratory tract infection in children is identifying the causative agent. the objective of the present study was to investigate the incidence of mycoplasma and chlamydia in the etiology of respiratory tract infections of children. the present study included 100 children, three months to 12 years of age, admitted to the outpatient department of pediatrics with such respiratory symptoms as fever, cough and respiratory distress. following a detai ... | 2006 | 17001543 |
| effect of pex, a noncatalytic metalloproteinase fragment with integrin-binding activity, on experimental chlamydophila pneumoniae infection. | chlamydophila pneumoniae is a pathogen that is involved in acute and chronic respiratory infections and that is associated with asthma and coronary artery diseases. in this study, we evaluated the effects of pex, a noncatalytic metalloproteinase fragment with integrin-binding activity, against experimental infections caused by c. pneumoniae. moreover, we investigated the relationships between c. pneumoniae and alpha(v)beta(3) integrin functions in order to explain the possible mechanism of actio ... | 2006 | 17005805 |
| arterial stiffness and chlamydia pneumoniae infection in coronary artery disease. is there a link? | we investigated the possible association between antichlamydial antibodies and pulse wave analysis (pwa) parameters in a cohort of patients with coronary artery disease (cad). | 2006 | 17012139 |
| automated identification of multiple micro-organisms from resequencing dna microarrays. | there is an increasing recognition that detailed nucleic acid sequence information will be useful and even required in the diagnosis, treatment and surveillance of many significant pathogens. because generating detailed information about pathogens leads to significantly larger amounts of data, it is necessary to develop automated analysis methods to reduce analysis time and to standardize identification criteria. this is especially important for multiple pathogen assays designed to reduce assay ... | 2006 | 17012284 |
| circulating chlamydia pneumoniae dna and advanced coronary artery disease. | chlamydia pneumoniae (c. pneumoniae) has been linked to atherosclerosis. detection of this pathogen in peripheral blood cells may be valuable in the diagnosis of disease state. this study aimed to evaluate the prevalence of circulating c. pneumoniae dna and its relationship with severity and extent of coronary artery disease (cad). | 2007 | 17023075 |
| [simultaneous detection by multiplex pcr of atypical bacterial pathogens involved in infections of respiratory tract. is it useful for the microbiological diagnosis of respiratory infections]. | the aim was to evaluate the "strategical place" of the new commercial test chlamylege (argene-biosoft-france) which allows the simultaneous detection in respiratory samples of chlamydophila pneumoniae, mycoplasma pneumoniae and most legionella species using a pcr multiplex. 41 patients with an atypical pneumonia were included, all standard procedures of diagnosis were done and in addition the chamylege test. a pathogen was identified in 12 patients, an other microorganisms than the 3 targeted by ... | 2006 | 17027196 |
| chlamydophila (chlamydia) pneumoniae infection of human astrocytes and microglia in culture displays an active, rather than a persistent, phenotype. | the intracellular pathogen chlamydia pneumoniae can cause persistent infections during which its morphologic, molecular, and pathogenic characteristics differ importantly from those of active infection. this bacterium was identified within astrocytes and microglia in the brain of late-onset alzheimer disease patients. we investigated whether infection of these two host cell types displays an active or persistent growth phenotype. | 2006 | 17031241 |
| new polymerase chain reaction-based diagnostic techniques for bacterial respiratory infection. | polymerase chain reaction protocols are now available for the diagnosis of all of the major bacterial respiratory tract pathogens. molecular techniques are also being used to determine the susceptibility of streptococcus pneumoniae and mycobacterium tuberculosis. in addition, polymerase chain reaction-based diagnosis will find a place in the investigation of the epidemiology of some pathogens such as bordetella pertussis and chlamydia pneumoniae. the added sensitivity will allow the detection of ... | 1998 | 17033378 |
| community-acquired pneumonia in adults. | efforts to reduce hospitalization or the length of stay are common topics in papers published last year. chlamydia pneumoniae is now recognized worldwide as a common pathogen in community-acquired pneumonia. a great variation in the frequency of various pathogens is found in different countries, stressing the importance of ascertaining the aetiological and epidemiological situation in each respective country. | 1998 | 17033380 |
| does chlamydia pneumoniae cause coronary heart disease? | evidence continues to accumulate to support a role for chlamydia pneumoniae in the pathogenesis of atherosclerosis, and in particular, coronary heart disease. in an analysis of 18 seroepidemiological studies, individuals with high-titer antibodies to chlamydia pneumoniae have at least a twofold or larger odds ratio for coronary heart disease compared with seronegative individuals. in addition, viable chlamydia pneumoniae has been cultured directly from atherosclerotic tissue, and has been demons ... | 1998 | 17033395 |
| ubiquinone (coenzyme q) biosynthesis in chlamydophila pneumoniae ar39: identification of the ubid gene. | ubiquinone is an essential electron carrier in prokaryotes. ubiquinone biosynthesis involves at least nine reactions in escherichia coli. 3-octaprenyl-4-hydroxybenzoate decarboxylase (ubid) is an important enzyme on the pathway and deletion of the ubid gene in e. coli gives rise to ubiquinone deficiency in vivo. a protein from chlamydophila pneumoniae ar39 had significant similarity compared with protein ubid from e. coli. based on this information, the protein-encoding gene was used to swap its ... | 2006 | 17033719 |
| chronic chlamydia pneumoniae infection may promote coronary artery disease in humans through enhancing secretion of interleukin-4. | atherosclerosis is an inflammatory response, probably to a range of initiating causes. chronic infection with chlamydia pneumoniae (c.pn) has been suggested as one cause, but the nature of the association is controversial, in large part due to lack of an identified mechanism to link infection with the atherosclerotic process in man. this study examined 139 consecutive subjects with stable chest pain, with the aim of correlating the serological status of c.pn infection with the pattern of secreti ... | 2006 | 17034570 |
| advances in antimicrobial therapy of community-acquired pneumonia. | community-acquired pneumonia has a significant impact upon healthcare in north america and worldwide. in the u.s. it is responsible for three to four million cases yearly and 78,000 deaths. it is not a homogeneous entity and it may be caused by a number of pathogens including streptococcus pneumoniae, the atypicals (mycoplasma pneumoniae, chlamydia pneumoniae and legionella species) haemophilus influenzae and gram-negative rods. while it is clear that directed therapy is the ideal, empiric thera ... | 1999 | 17035770 |
| [chlamydia pneumoniae infections]. | chlamydia pneumoniae, an obligate intracellular human pathogen, causes infections of the respiratory tract. it is a significant cause of both lower and upper acute respiratory illnesses, including pneumonia, bronchitis, pharyngitis and sinusitis. most respiratory infections caused by c. pneumoniae are mild or asymptomatic. some studies have suggested a possible association of c. pneumoniae infection and acute exacerbations of asthma and chronic obstructive pulmonary disease (copd). seroepidemiol ... | 2006 | 17037392 |
| [treatment and course of community-acquired pneumonia caused by atypical pathogens]. | to study the course of disease and outcomes in a group of patients with community-acquired pneumonia caused by atypical pathogens (mycoplasma pneumoniae, legionella species ,coxiella burnetii, and chlamydophila pneumoniae) according to the empiric treatment received. | 2006 | 17040657 |
| [serologic diagnosis of chlamydial and mycoplasma pneumoniae infections]. | the diagnosis of chlamydia trachomatis infection can be based either on direct detection of the organism or its components or indirectly by measuring antibodies as markers of the individual's response to the infection. the latter is currently of limited value. neither igg or iga antibodies can be used to diagnose current genital infection by chlamydia trachomatis or to exclude such an infection. there is no solid ground as yet for the use of iga antibodies as a marker of persistant or unresolved ... | 2006 | 17040871 |
| influence of particle size on drug delivery to rat alveolar macrophages following pulmonary administration of ciprofloxacin incorporated into liposomes. | in order to confirm the efficacy of ciprofloxacin (cpfx) incorporated into liposomes (cpfx-liposomes) for treatment of respiratory intracellular parasite infections, the influence of particle size on drug delivery to rat alveolar macrophages (ams) following pulmonary administration of cpfx-liposomes was investigated. cpfx-liposomes were prepared with hydrogenated soybean phosphatidylcholine (hspc), cholesterol (ch) and dicetylphosphate (dcp) in a lipid molar ratio of 7/2/1 by the hydration metho ... | 2006 | 17043040 |
| aetiology and resistance patterns of community-acquired pneumonia in león, nicaragua. | we conducted a prevalence study to gain greater insight into the aetiology, bacterial resistance and risk factors for community-acquired pneumonia (cap) in the region of león, nicaragua. during the period from july 2002 to january 2005, all consecutive patients with signs and symptoms suggestive of cap were included in the study. sputum samples, paired serum samples and urinary samples were collected for the detection of respiratory pathogens. the most frequently identified pathogens were strept ... | 2006 | 17046211 |
| chlamydia pneumoniae infection and mpo-anca-associated glomerulonephritis. | 2007 | 17047003 | |
| chlamydophila (chlamydia) pneumoniae in the alzheimer's brain. | we assessed the presence and characteristics of the intracellular pathogen chlamydophila (chlamydia) pneumoniae in brain-tissue samples from 25 patients with late-onset alzheimer's disease (ad) and 27 non-ad control individuals. 20/27 ad patients, but only 3/27 controls, were pcr-positive in multiple assays targetting the cpn1046 and cpn0695 genes. culture of the organism from brain-tissue homogenate from one ad patient, and assessment of various chlamydial transcripts in rna preparations from s ... | 2006 | 17052268 |
| serology of chlamydia pneumoniae in patients with chronic cough. | chronic cough is one of the more common respiratory symptoms. controversy exists as to whether chlamydia infection is associated with chronic cough. as such, the association of chronic cough with serological evidence of chlamydia pneumoniae (c. p) infection and a systemic inflammatory marker was assessed. | 2006 | 17052312 |
| tissue microarray (tma) analysis of normal and persistent chlamydophila pneumoniae infection. | chlamydophila pneumoniae infection has been implicated as a potential risk factor for atherosclerosis, however the mechanism leading to persistent infection and its role in the disease process remains to be elucidated. | 2006 | 17052347 |
| localization of the hypothetical protein cpn0797 in the cytoplasm of chlamydia pneumoniae-infected host cells. | using antibodies raised with chlamydial fusion proteins, we have localized a protein encoded by the hypothetical open reading frame cpn0797 in the cytoplasm of chlamydia pneumoniae-infected host cells. the anti-cpn0797 antibodies specifically recognized cpn0797 protein without cross-reacting with either cpafcp or cpn0796, the only two proteins known to be secreted into the host cell cytosol by c. pneumoniae organisms. thus, cpn0797 represents the third c. pneumoniae protein secreted into the hos ... | 2006 | 17057097 |
| global transcriptional upregulation in the absence of increased translation in chlamydia during ifngamma-mediated host cell tryptophan starvation. | the developmentally regulated intracellular pathogen chlamydia pneumoniae is a natural tryptophan auxotroph. these organisms survive tryptophan starvation induced by host cell activation with ifngamma by blocking maturation to the infectious form. in most bacteria, the stringent response is induced during amino acid starvation to promote survival. however, the response of obligate intracellular pathogens, which are predicted to lack stringent responses to amino acid starvation, is poorly charact ... | 2006 | 17059564 |
| outbreak of respiratory tract infections on an islet in korea: possible chlamydia pneumoniae infection. | in march 2004, we experienced an outbreak of chlamydia pneumoniae infection on an islet of korea. in order to assess the significance of the epidemic, we performed a mass examination of 137 students (7-16 years old; male, 69; female, 58) at a school. the examination consisted of a questionnaire inquiring about respiratory symptoms, a serum antibody test for c. pneumoniae using a microimmunofluorescence (mif) method and enzyme-linked immunosorbent assay (elisa), and nasopharyngeal swab tests to d ... | 2006 | 17060694 |
| effect of clarithromycin on cytokines and chemokines in children with an acute exacerbation of recurrent wheezing: a double-blind, randomized, placebo-controlled trial. | clarithromycin is postulated to possess immunomodulatory properties in addition to its antimicrobial activity. | 2006 | 17069099 |
| a role for archaeal organisms in development of atherosclerotic vulnerable plaques and myxoid matrices. | vulnerable plaques are characterized by a myxoid matrix, necrotic lipidic core, reactive oxygen species, and high levels of microorganisms. aerobic microbes such as chlamydophila pneumoniae and mycoplasma pneumoniae usually do not survive in oxidative stress media. archaea are anaerobic microbes with powerful anti-oxidative enzymes that allow detoxification of free radicals whose presence might favor the survival of aerobic microorganisms. we searched for archaeal organisms in vulnerable plaques ... | 2006 | 17072447 |
| chlamydia pneumoniae replicates in kupffer cells in mouse model of liver infection. | to develop an animal model of liver infection with chlamydia pneumoniae (c. pneumoniae) in intraperitoneally infected mice for studying the presence of chlamydiae in kupffer cells and hepatocytes. | 2006 | 17072977 |
| outbreak of chlamydia pneumoniae infection in a japanese nursing home, 1999-2000. | to identify risk factors for infection and severe illness due to chlamydia pneumoniae. | 2006 | 17080373 |
| both hepatitis c virus and chlamydia pneumoniae infection are related to the progression of carotid atherosclerosis in patients undergoing lipid lowering therapy. | recent experimental and epidemiological findings suggest that infectious agents may play a role in the development and progression of atherosclerosis. we previously reported that chlamydia pneumoniae (c. pneumoniae) infection reduces the effectiveness of lipid-lowering therapy for carotid atherosclerosis and that this micro-organism may play a role in the progression of atherosclerosis. in this study, we investigated the possible association between hepatitis c virus (hcv) infection and carotid ... | 2006 | 17087362 |
| [atherosclerosis and infection?]. | atherosclerosis is guided by chronicle inflammation process. in the last decades of the 20th century, studies considering infection another possible risk factor of atherosclerosis development were written. helicobacter pylori, porphyromas gingivalis, some viruses but most frequently chlamydia pneumonie are infection agens mentioned in these studies. some of them emphasize also combined infections caused by more pathogenic factors having influence on vascular inflammation. serological, epidemiolo ... | 2006 | 17091609 |
| 13--antibiotic therapy of community-acquired pneumonia (cap) caused by atypical agents. | macrolides, fluoroquinolones, doxycycline, and ketolides show a good intrinsic activity against intracellular pathogens which are responsible for a variable percentage of community-acquired pneumonia (cap). these therapeutic agents all seem effective in treating most cases of cap caused by mycoplasma pneumoniae, chlamydia pneumoniae, or legionella spp. among quinolones, the more recent fluoroquinolones, such as gemifloxacin or moxifloxacin, generally show a better intrinsic activity than the old ... | 2006 | 17095177 |
| re: "antibiotic use and risk of multiple sclerosis". | 2006 | 17095537 | |
| bacterial diversity in aortic aneurysms determined by 16s ribosomal rna gene analysis. | aortic aneurysms are common vascular conditions that cause considerable morbidity and mortality. understanding of the mechanisms involved in the pathogenesis of the condition remains limited. recently, infection has been suggested as possible contributor in the development of the disease. the aim of the present study was to examine aortic aneurysms for the presence of bacterial dna using polymerase chain reaction (pcr) targeting the 16s ribosomal rna (rrna) gene, followed by cloning and sequenci ... | 2006 | 17098542 |
| prevalence and clinical presentations of atypical pathogens infection in community acquired pneumonia in thailand. | to determine the prevalence of atypical pneumonia and clinical presentations in patients with community acquired pneumonia (cap). | 2006 | 17100378 |
| hypothetical protein cpn0308 is localized in the chlamydia pneumoniae inclusion membrane. | the hypothetical protein encoded by chlamydia pneumoniae open reading frame cpn0308 was detected in inclusion membranes of c. pneumoniae-infected cells using antibodies raised with cpn0308 fusion proteins. the anti-cpn0308 antibodies did not cross-react with inca, a known c. pneumoniae inclusion membrane protein, although the anti-cpn0308 antibody staining overlapped with the anti-inca antibody labeling. the labeling of the inclusion membrane by the anti-cpn0308 antibody was specifically blocked ... | 2007 | 17101661 |
| evaluation of serological tests detecting chlamydophila pneumoniae-specific immunoglobulin m antibody. | to evaluate a newly developed enzyme-linked immunosorbent assay (elisa) (hitazyme c. pneumoniae) detecting chlamydophila pneumoniae-specific immunoglobulin m (igm) antibody, we compared the assay with culturing, immunoblotting and the microimmunofluorescence (mif) test. | 2006 | 17106155 |
| isolation and antimicrobial susceptibilities of chlamydial isolates from western barred bandicoots. | a range of species of chlamydiales have previously been detected in a variety of australian marsupials, including koalas and western barred bandicoots. thirty-seven ocular, urogenital, or nasal swabs were obtained from 21 wild western barred bandicoots. chlamydia culture and antibiotic susceptibility testing were performed for cycloheximide-treated hep-2 cells in 96-well microtiter plates. chlamydia spp. were isolated from 11 specimens from 9 (42.8%) bandicoots. all isolates were identified as c ... | 2007 | 17122017 |
| a study on immunopathogenetic mechanisms of atherosclerotic process caused by chronic infection of chlamydia pneumoniae in rats (ratus novergicus). | this study was aimed to determine the correlations between duration of chlamydia pneumoniae infection and the development of atherosclerotic process in white-rats' (ratus novergicus) aorta. | 2006 | 17132885 |
| molecular mimicry and horror autotoxicus: do chlamydial infections elicit autoimmunity? | all species of the order chlamydiales are obligate intracellular eubacterial pathogens of their various hosts. two chlamydial species, chlamydia trachomatis and chlamydia pneumoniae, are primarily human pathogens, and each is known to cause important diseases. some strains of c. trachomatis are sexually transmitted and frequently cause severe reproductive problems, primarily in women. other strains of the organism serve as the aetiological agents for blinding trachoma, still the leading cause of ... | 2006 | 17134529 |
| management of group a beta-hemolytic streptococcal pharyngotonsillitis in children. | acute pharyngotonsillitis is one of the most common infections encountered by pediatricians and family physicians. according to the us vital health statistics report, acute pharyngotonsillitis is responsible for more than 6 million office visits each year by children younger than 15 years of age and an additional 1.8 million visits by adolescents and young adults aged 15 to 24 years. most children with acute pharyngotonsillitis have symptoms that can be attributed to infection with a respiratory ... | 2006 | 17137534 |
| the association of metabolic syndrome and chlamydia pneumoniae, helicobacter pylori, cytomegalovirus, and herpes simplex virus type 1: the persian gulf healthy heart study. | the metabolic syndrome together with insulin resistance and their consequences are basic factors in pathogenesis of atherosclerosis. chronic infections with herpes simplex virus type 1 (hsv-1), cytomegalovirus (cmv), and chlamydia pneumoniae are associated with the development of atherosclerosis and coronary heart disease. the infectious aspects of metabolic syndrome have not been investigated. | 2006 | 17140429 |
| the association of carotid plaque inflammation and chlamydia pneumoniae infection with cerebrovascular symptomatology. | inflammation and infection have been implicated in the pathogenesis of carotid artery atherosclerosis, but their role in cerebrovascular disease symptomatology is not so well defined. we hypothesized that carotid disease symptomatology was associated with specific serologic markers of inflammation and chlamydia pneumoniae infection and the presence of the pathogen and concentration of tumor necrosis factor-alpha (tnf-alpha) on the atheroma. | 2006 | 17145421 |
| chlamydia pneumoniae--induced macrophage foam cell formation is mediated by toll-like receptor 2. | chlamydia pneumoniae induces macrophage foam cell formation, a hallmark of early atherosclerosis, in the presence of low-density lipoprotein (ldl). this study examined the role that toll-like receptor 2 (tlr2) and tlr4 may play in pathogen-induced foam cell formation. murine macrophage raw 264.7 cells either infected with c. pneumoniae or treated with the tlr4 ligand e. coli lipopolysaccharide (lps) or the tlr2 ligand pam(3)-cys-ala-gly-oh (pam) became oil red o-stained foam cells and showed inc ... | 2007 | 17145941 |
| interventional and medical treatment of acute heart failure due to inflammation: four cases. | four patients (aged 15-41 years, mean age 26.7 years) with fulminant myocarditis undergoing mechanical circulatory support are reported. all patients suffered from acute low-output syndrome refractory to inotropic support. diagnosis was confirmed by histology and immunohistochemistry. rt-pcr (reverse transcription-polymerase chain reaction) from endomyocardial biopsy specimens revealed parvovirus b19 in two patients and a coinfection with chlamydia pneumoniae and parvovirus b19 in one patient. m ... | 2006 | 17149677 |