Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| [evaluating the impact of human papilloma virus infection on prognosis of juvenile laryngeal papilloma]. | to evaluate the relationship between human papilloma virus (hpv) and pathological characteristics of juvenile laryngeal papillomas (jlp). | 2002 | 15510659 |
| two different types of human papillomavirus in a patient with carcinomas of the vulva and cervix. | 1997 | 15511786 | |
| women with polymorphisms of methylenetetrahydrofolate reductase (mthfr) and methionine synthase (ms) are less likely to have cervical intraepithelial neoplasia (cin) 2 or 3. | the role of nutrient-related genetic susceptibility factors for pre-cancerous lesions is gaining attention. we conducted a study to examine associations between polymorphisms in folate pathway coenzymes (methylenetetrahydrofolate reductase [mthfr] and methionine synthase [ms]) and cervical intraepithelial neoplasia (cin) 2 or 3 in a population exposed to folic acid by the food fortification program in the united states. status of mthfr and ms and circulating concentrations of folate, vitamins b1 ... | 2005 | 15514969 |
| regression of low-grade squamous intra-epithelial lesions in young women. | the aim of this study was to assess the probability of low-grade squamous intra-epithelial lesion (lsil) regression in young women, and to examine the factors associated with this regression. | 2004 | 15530628 |
| phase 1 study of hpv16-specific immunotherapy with e6e7 fusion protein and iscomatrix adjuvant in women with cervical intraepithelial neoplasia. | persistent infection of cervical epithelium with "high risk" human papillomavirus (hpv) results in cervical intraepithelial neoplasia (cin) from which squamous cancer of the cervix can arise. a study was undertaken to evaluate the safety and immunogenicity of an hpv16 immunotherapeutic consisting of a mixture of hpv16 e6e7 fusion protein and iscomatrix adjuvant (hpv16 immunotherapeutic) for patients with cin. | 2004 | 15531034 |
| p53 codon 72 polymorphic variants, loss of allele-specific transcription, and human papilloma virus 16 and/or 18 e6 messenger rna expression in squamous cell carcinomas of the head and neck. | a polymorphism at codon 72 of the human tumor suppressor p53 determines translation into either arginine or proline. yet, the impact of this amino acid variability on the risk to develop malignant tumors, particularly carcinomas associated with human papilloma virus (hpv) infections, remains unresolved because of contradictory results. to address a potential correlation between the different genotypes and the manifestation of squamous cell carcinomas of the head and neck (scchn), we determined t ... | 2004 | 15533911 |
| evaluation of log-rank tests for infrequent observations from a multi-state process, with application to hpv vaccine efficacy. | genital infection by human papillomavirus (hpv) is a common sexually transmitted disease, with over 25 per cent prevalence among young women in the us. infections are usually without symptoms and transient (or reversible), but a small proportion of infections persist and are believed to be responsible for nearly all cervical cancers and precursor lesions such as cervical intraepithelial neoplasia (cin). therefore, successful vaccines against persistent hpv infections could have a great impact in ... | 2004 | 15534891 |
| detection of high-risk hpv dna in semen and its association with the quality of semen. | the effects of seminal high-risk human papillomavirus (hpv) dna were assessed on the quality of semen. semen samples of 65 men participating in the ongoing finnish hpv family study were collected. semen analyses were done by the guidelines of the nordic association for andrology. hpv dna was detected by nested polymerase chain reaction and confirmed by southern blot hybridization for high-risk types. altogether, 10/65 men (15.4%) had high-risk hpv dna positive semen sample. seminal high-risk hpv ... | 2004 | 15537460 |
| bowenoid papulosis at the site of prior herpes progenitalis. | a 35-year-old dentist came to the authors' attention for papular and vegetating lesions that had appeared on his penile shaft over the last 2 months. the lesions differed in their features: pink and vegetating on the left side, brown and papular on the right side (figure 1). the obvious clinical diagnoses of genital warts on the left and bowenoid papulosis on the right were confirmed by punch biopsies, which showed epithelial hyperplasia with diffuse cell vacuolization (koilocytes)in the left bi ... | 2004 | 15538089 |
| elevated amount of human papillomavirus 31 dna in a squamous cell carcinoma developed from bowenoid papulosis. | a 50-year-old woman presented with asymptomatic, multiple black macules on the genitalia for 6 months. she presented multiple, round to irregularly shaped, black macules on her labia major and perineum. a keratotic reddish nodule was found on one of the macules. the results of laboratory investigations showed pancytopenia and a decreased cd4/cd8 ratio. a lymphocyte stimulation test showed a decreased response. the histological examination of a biopsy specimen led us to the diagnosis of bowenoid ... | 2004 | 15539898 |
| rapid enrichment of human papillomavirus (hpv)-specific polyclonal t cell populations for adoptive immunotherapy of cervical cancer. | the majority of cervical cancers are caused by human papillomavirus type 16 (hpv16). cervical cancer is associated with an ineffective host immune response against the hpv16 oncoproteins, characterized by the lack of the strong e6-specific t-helper type 1 (th1) immunity that is generally present in healthy individuals, the presence of improperly polarized hpv16e6- and e7-specific cd4(+) t cells and increased numbers of regulatory t cells. therefore, immunotherapeutic intervention is likely to re ... | 2005 | 15540211 |
| efficacy of a bivalent l1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: a randomised controlled trial. | vaccination against the most common oncogenic human papillomavirus (hpv) types, hpv-16 and hpv-18, could prevent development of up to 70% of cervical cancers worldwide. we did a randomised, double-blind, controlled trial to assess the efficacy, safety, and immunogenicity of a bivalent hpv-16/18 l1 virus-like particle vaccine for the prevention of incident and persistent infection with these two virus types, associated cervical cytological abnormalities, and precancerous lesions. | 2004 | 15541448 |
| plasmid encoding papillomavirus type 16 (hpv16) dna constructed with codon optimization improved the immunogenicity against hpv infection. | human papillomavirus type 16 (hpv16) infections can cause neoplasia, which is thought to be closely associated with the development of cervical cancers. in the study, we attempted to construct a dna plasmid encoding a hpv16 capsid protein (l1) and a hpv16 oncoprotein (e7), which was capable of preventing hpv16 infection and eliminating hpv16-infected cells. a plasmid, l1e7hpsca1, encoding the l1 and e7 genes with the codon usage optimized for mammalian cell expression, was constructed. mutations ... | 2004 | 15542183 |
| verification bias-corrected estimators of the relative true and false positive rates of two binary screening tests. | the relative accuracy of two binary screening tests can be quantified by estimating the relative true positive rate (rtpr) and relative false positive rate (rfpr) between the two tests. ideally all study subjects are administered both screening tests as well as a gold standard to determine disease status. in practice, however, often the gold standard is so invasive or costly that only a percentage of study subjects receive disease verification and the percentage differs depending on the results ... | 2005 | 15543634 |
| evidence for practice: oral contraception and risk of cervical cancer. | the issue of continued oral contraceptive use among women with abnormal pap smears may be controversial due to reported evidence of an increased risk of cervical cancer among long term oral contraceptive users. this article reviews the evidence concerning oral contraception and cervical cancer risk. the role of human papilloma virus (hpv) and proposed mechanisms for the development of cervical cancer are explained. evidence from world health organization (who) studies and additional research evi ... | 2004 | 15543923 |
| hybrid capture 2 viral load and the 2-year cumulative risk of cervical intraepithelial neoplasia grade 3 or cancer. | the purpose of this study was to determine the clinical value of a semiquantitative measure of human papillomavirus viral load by the hybrid capture 2 assay for stratification of the risk of histologic cervical intraepithelial neoplasia grade 3 or carcinoma. | 2004 | 15547529 |
| evaluating human papillomavirus vaccination programs. | human papillomavirus (hpv) has been implicated as the primary etiologic agent of cervical cancer. potential vaccines against high-risk hpv types are in clinical trials. we evaluated vaccination programs with a vaccine against hpv-16 and hpv-18. we developed disease transmission models that estimated hpv prevalence and infection rates for the population overall, by age group, by level of sexual activity within each age group, and by sex. data were based on clinical trials and published and unpubl ... | 2004 | 15550200 |
| incidence, duration, and determinants of cervical human papillomavirus infection in a cohort of colombian women with normal cytological results. | data on the incidence and determinants of human papillomavirus (hpv) infection in women >30 years old are scarce. to address this, a cohort of 1610 women--15-85 years old, hpv negative, and with normal cytological results at baseline--was monitored every 6 months for an average of 4.1 years. information on risk factors and cervical samples for cytological testing and detection and typing of hpv dna were obtained at each visit. the incidence of high-risk types was higher than that of low-risk typ ... | 2004 | 15551205 |
| incidence, pathophysiology and treatment of cervical cancer. | cervical cancer is the third most common cancer affecting women. while not in itself a sexually transmitted disease, cervical cancer is linked to the presence of the human papilloma virus, which is sexually transmitted. survival rates are significantly higher where diagnosis is early, and a national screening programme has reduced mortality in the uk. however, uptake is low in some groups and nurses have a role in increasing uptake. | 2004 | 15552491 |
| correlation of immunochemical detection of hpv l1 capsid protein in pap smears with regression of high-risk hpv positive mild/moderate dysplasia. | to immunostain pap smears of high-risk (hr) hpv dna-positive early squamous lesions for detecting hpv l1 protein. | 2004 | 15560527 |
| [correlation between dna load of human papillomavirus and recurrence of condyloma acuminata]. | to determine the correlation between dna load of human papillomavirus (hpv) and recurrence of condyloma acuminata (ca). | 2004 | 15562772 |
| [correlation between p53 codon 72 polymorphism and tumorigenesis of cervical cancer]. | the p53 codon 72 polymorphism affects human papillomavirus (hpv) e6-mediated degradation of p53. this study was to investigate distribution of p53 polymorphism in guangdong women, and relationship between p53 polymorphism and tumorigenesis of cervical cancer. | 2004 | 15566643 |
| therapy of cutaneous human papillomavirus infections. | human papillomaviruses (hpv) are double-stranded dna viruses, which result in a variety of clinical manifestations according to type. the most common cutaneous lesions include warts located on the skin and genitalia. because there is currently no cure for hpv infection, treatment focuses on the alleviation of signs and symptoms. unfortunately, therapy has not been proved to affect transmissibility. traditional treatment modalities have focused on the destruction of infected tissue through a vari ... | 2004 | 15571494 |
| functional genetic screen for genes involved in senescence: role of tid1, a homologue of the drosophila tumor suppressor l(2)tid, in senescence and cell survival. | we performed a genetic suppressor element screen to identify genes whose inhibition bypasses cellular senescence. a normalized library of fragmented cdnas was used to select for elements that promote immortalization of rat embryo fibroblasts. fragments isolated by the screen include those with homology to genes that function in intracellular signaling, cellular adhesion and contact, protein degradation, and apoptosis. they include mouse tid1, a homologue of the drosophila tumor suppressor gene l ... | 2004 | 15572682 |
| inhibited interpersonal coping style predicts poorer adherence to scheduled clinic visits in human immunodeficiency virus infected women at risk for cervical cancer. | one of the most common gynecologic conditions among hiv+ women is cervical dysplasia, the precancerous phase of cervical cancer. therefore, adherence to gynecology visits may be among the most important health care practices for hiv+ women. however, no research has evaluated the psychosocial factors associated with health care practices among hiv+ women at risk for cervical cancer. | 2004 | 15576258 |
| disseminated human papillomavirus type 11 infection in a patient with pemphigus vulgaris: confirmed by dna analysis. | depending on the type of epithelium infected, human papillomaviruses (hpvs) are often subclassified as "cutaneous" or "mucosal" types of hpv. hpv type 11 is a mucosal type of virus and infects the genital tract or larynx. disseminated hpv-11 infection involving multiple body sites in cases of pemphigus vulgaris (pv) has not been reported. we report here an unusual case of severe pemphigus vulgaris associated with disseminated hpv-11 infection on the arms, hands, axillae, chest, abdomen, and both ... | 2004 | 15577767 |
| implementing recommendations for the early detection of breast and cervical cancer among low-income women. | scope of the problem: among u.s. women, breast cancer is the most commonly diagnosed cancer and remains second only to lung cancer as a cause of cancer-related mortality. the american cancer society (acs) estimates that 182,800 new cases of female breast cancer and 41,200 deaths from breast cancer will occur in 2000. since the 1950s, the incidence of invasive cervical cancer and mortality from this disease have decreased substantially; much of the decline is attributed to widespread use of the p ... | 2000 | 15580731 |
| apoptosis-related proteins and cervical intraepithelial neoplasia in human immunodeficiency virus-seropositive women. | to evaluate the expression of bcl-2, p-53, ki-67, and apoptosis as evidenced by nuclear dna fragmentation in cervical biopsies obtained from human immunodeficiency virus (hiv)-seropositive and hiv-seronegative women with a history of intravenous drug abuse. | 2004 | 15581953 |
| proteins of the pias family enhance the sumoylation of the papillomavirus e1 protein. | sumoylation of the papillomavirus (pv) origin binding helicase e1 protein is critical for its function. consequently, factors modulating the sumoylation of e1 could ultimately alter the outcome of a papillomavirus infection. we investigated the role played by phosphorylation and two known sumo e3 ligases, ranbp2 and pias proteins, on the sumoylation of e1. e1 sumoylation was unaffected by phosphorylation as both wild-type and pseudo-phosphorylation mutants of bpv e1 exhibited similar sumoylation ... | 2005 | 15582666 |
| p16(ink4a) is a surrogate biomarker for a subset of human papilloma virus-associated dysplasias of the uterine cervix as determined on the pap smear. | recently, p16(ink4a) has been identified as a biomarker for human papilloma virus (hpv)-induced dysplastic lesions of the cervix and it has been suggested that it may be a useful diagnostic aid for these lesions. this study therefore was performed to determine the utility of p16 expression in a series of papanicolaou (pap) smears collected in liquid medium and to determine its benefit, if any, over hpv testing. one hundred seven cases, including 23 negative cases, 34 with low-grade squamous intr ... | 2005 | 15584047 |
| [descriptive study of hpv prevalence in a private consultation]. | human papillomavirus (hpv) infection is the main aethiological factor in the development of squamous cervical neoplasia. nowadays molecular hybridization is the most adequated method to detect hpv. study is based on the hpv assay by means of mixed hybridization and capture of specific sequences of viral dna. detection of hpv by hybridization and capture is a very useful technique in patients with non-definitive cytologies of viral action, but that display high clinical suspect for such a infecti ... | 2004 | 15587292 |
| [cervical cancer. current view of its epidemiology and risk factors]. | an epidemiologic analysis and a global evaluation of risk factors related to the etiopathogenesis of cervical cancer are reported here. cervical cancer is the second cause of female malignancies worldwide and represents a health problem in some countries of africa and latin america like haiti, zimbabwe, bolivia and ecuador, with incidence rates from 44.2 to 93.9 per 100,000. highest death rates are reported in haiti, nicaragua, ecuador and mexico (53.5 to 17.1 per 100,000, respectively). althoug ... | 2004 | 15587822 |
| a viral dna-binding domain elicits anti-dna antibodies of different specificities. | we have previously demonstrated that immunization of normal mice with a defined protein:dna complex comprising the c-terminal dna-binding domain of the human papillomavirus e2 protein and its cognate site 35 oligonucleotide, results in high antibody titers against both e2 and its target dna sequence. here we show that repeated immunization with the isolated form of the e2 domain also elicits anti-dna antibodies, but in this case, no preferential binding for a given sequence was observed, indicat ... | 2005 | 15589321 |
| reflections on cervical cancer. | the incidence of invasive cervical cancer and consequently mortality decreased due to adequate screening programmes in canada from 1969 to 2003. systematic cervical screening programmes similar to those in europe should be implemented throughout canada. the new techniques, including a liquid-based cytology, associated or not with identifying human papilloma virus (hpv), allow the best results in prevention and early diagnosis of cervical cancer and high-grade squamous intraepithelial lesions (hs ... | 2004 | 15597840 |
| low-dose topical delivery of all-trans retinoic acid for cervical intraepithelial neoplasia ii and iii. | the objective of this study was to determine an effective dose for all-trans retinoic acid (atra) delivered with a cervical cap and sponge for 4 days to women with cervical intraepithelial neoplasia (cin) ii/iii. | 2004 | 15598773 |
| distribution and prevalence of human papillomavirus genotypes in routine pap smear of 2,470 korean women determined by dna chip. | we examined human papillomavirus (hpv) genotype distribution and prevalence from routine pap smear cases in korean women using dna chip. patients and | 2004 | 15598774 |
| a case of bowenoid papulosis of the penis successfully treated with topical imiquimod cream 5%. | bowenoid papulosis is a pre-malignant condition affecting the ano-genital area. pathogenesis may be associated with high-risk human papillomavirus genotypes, and sexual transmission is the most likely mode of acquisition. risk of progression to invasive disease is low. treatment usually involves locally destructive or ablative therapies. we report well-tolerated, successful clearance of bowenoid papulosis of the penis in a 25-year-old male, using topical aldara (imiquimod) cream 5%, once every o ... | 2004 | 15601490 |
| [effects of imiquimod on latent human papillomavirus anal infection in hiv-infected patients]. | high risk human papillomaviruses (hpv) have emerged as risk factors for anal carcinoma particularly in hiv-infected patients who demonstrate a high rate of anal hpv infection. considering the relationship between the presence of anal infection and the development of neoplastic lesions, we wished to assess the capacity of imiquimod to eradicate latent hpv infection in hiv-infected patients. | 2004 | 15602380 |
| association of viral factors with non-familial breast cancer in taiwan by comparison with non-cancerous, fibroadenoma, and thyroid tumor tissues. | to study the etiologic factors of non-familial breast cancer, the polymerase chain reaction (pcr) and southern hybridization were used to detect six viruses including human papillomavirus (hpv), cytomegalovirus (cmv), epstein-barr virus (ebv), herpes simplex virus (hsv)-1, hsv-2, and human herpesvirus (hhv)-8 dna in 69 patients with breast cancer and 60 specimens from non-cancerous or other individuals with thyroid tumors or fibroadenoma (non-breast cancer controls). two specimens from patients ... | 2005 | 15602723 |
| polymorphism of human papillomavirus type 31 isolates infecting the genital tract of hiv-seropositive and hiv-seronegative women at risk for hiv infection. | the genomic polymorphism of high-risk human papillomavirus (hpv) for types other than 16 has not been extensively described. we describe here the genomic polymorphism of high-risk hpv type 31 in 79 women (62 hiv-seropositive, 17 hiv-seronegative) by pcr-sequencing of the long control region (lcr), e6 and e7. lcr polymorphism was generated by 25 (6.4%) single-nucleotide variations over 391 bases. each variant compared to the prototype contained from 2 to 13 variations (mean of 9.4 +/- 3.3, median ... | 2005 | 15602735 |
| treatment of bowenoid and basaloid vulvar intraepithelial neoplasia 2/3 with imiquimod 5% cream. | to evaluate the effectiveness and safety of imiquimod 5% for the treatment of bowenoid and basaloid vulvar intraepithelial neoplasia (vin) and to evaluate recurrences following treatment. | 2004 | 15603097 |
| [effect of anti-hpv16 e6-ribozyme on cell proliferation and invasiveness of cervical carcinoma cell line caski]. | to investigate the effects of anti-hpv16-ribozyme on the cell proliferation and invasiveness of cultured cervical cancer cell line caski. | 2004 | 15604060 |
| heparin-based elisa reduces background reactivity in virus-like particle-based papillomavirus serology. | the interaction between human papillomavirus (hpv) particles and cell surface heparan sulfate requires intact conformation of the hpv particles. type-specific hpv serology is currently based on virus-like particles (vlps) with intact conformation. presence of incorrectly folded vlps in vlp preparations is recognized as an important cause of cross-reactivity in hpv serology. heparin-coated microtitre plates were evaluated for capturing conformationally correct vlps and improving the type specific ... | 2005 | 15604432 |
| expression of p16 protein is associated with human papillomavirus status in tonsillar carcinomas and has implications on survival. | our recent analysis of papillomavirus (hpv) dna in different malignant head and neck tumors revealed that hpv infections occurred most frequently in tonsillar carcinomas (58%) and that 84% of positive cases contained the highly oncogenic hpv type 16. we could also present data in favor of the hypothesis that in view of their clinical behavior and the involved risk factors hpv-positive and hpv-negative tonsillar carcinomas may represent two separate tumor entities. looking for a surrogate marker, ... | 2005 | 15608419 |
| cross-typic specificity and immunotherapeutic potential of a human hpv16 e7-specific ctl line. | cervical cancer (cacx) is strongly associated with human papillomavirus (hpv) infection, particularly hpv types 16 and 18. the constitutive expression of hpv e6 and e7 proteins in cacx makes them attractive targets for ctl based immunotherapy. however cervical carcinomas may have features, e.g., antigen processing defects, that limit the effectiveness of hpv specific ctl. furthermore most vaccine development has concentrated on hpv type 16, and it is not clear whether such vaccines could induce ... | 2005 | 15609329 |
| generation of dendritic cells from rabbit bone marrow mononuclear cell cultures supplemented with hgm-csf and hil-4. | the in vitro generation of dendritic cells (dcs) from either blood or bone marrow has been accomplished for humans and a number of other species. this ability has facilitated the opportunity to test the efficacy of dc vaccines in various tumor models. the cottontail rabbit papillomavirus (crpv) model is the most clinically relevant animal model for human papillomavirus (hpv)-associated carcinogenesis. the crpv model has been used to test various preventative and therapeutic vaccination strategie ... | 2005 | 15621303 |
| the characteristics of human papillomavirus dna in head and neck cancers and papillomas. | to determine the prevalence, type, physical state, and viral load of human papillomavirus (hpv) dna in cases of head and neck cancer and recurrent respiratory papillomatosis (rrp). | 2005 | 15623482 |
| modification of hpv 16 e7 genes: correlation between the level of protein expression and ctl response after immunization of c57bl/6 mice. | immunization with a codon-optimized hpv 16 e7 gene was shown to yield higher levels of e7-specific cytotoxic t cells [liu wj, gao f, zhao kn, zhao w, fernando gj, thomas r, et al. codon modified human papillomavirus type 16 e7 dna vaccine enhances cytotoxic t-lymphocyte induction and anti-tumour activity. virology 2002;301:43]. here, we sought to verify the hypothesis that there is a direct correlation between the level of protein expression and immunogenicity in mice. we generated hpv 16 e7 exp ... | 2005 | 15629358 |
| a cost-effectiveness analysis of four management strategies in the determination and follow-up of atypical squamous cells of undetermined significance. | atypical squamous cells of undetermined significance (asc-us) are the most common abnormal cytological result on papanicolaou (pap) smear. we analyzed four management strategies in a hypothetical cohort of women divided by age group: (1) immediate colposcopy, (2) repeat cytology after an asc-us pap smear result, (3) conventional pap with reflex human papillomavirus (hpv) testing, and (4) liquid-based cytology with reflex hpv testing. parameter variables were collected from previously published d ... | 2005 | 15637677 |
| cell lines used in prostate cancer research: a compendium of old and new lines--part 2. | this is part 2 of a 2-part review. research into the molecular mechanisms underlying the various aspects of prostate cancer (pca) requires the use of in vivo and in vitro model systems. in the last few years many new cell lines have been established by investigators from primary tissue sources and clonal derivatives of previously established lines. therefore, the purpose of this 2-part review is to catalogue the current human cell lines developed for pca research, as reported in the literature. ... | 2005 | 15643173 |
| [genital condylomatosis and pregnancy associated with chorioamnionitis and premature delivery]. | genital condylomas are produced by the human papilloma virus. on many occasions they are associated with other genital infections (fungi, trichomonas and vaginosis). pregnancy favours the appearance of condylomas in the anogenital region. on the occasion of a case of genital condylomatosis associated with chorioamnionitis that resulted in a premature delivery, we carry out a review the literature. | 2004 | 15644890 |
| impact of transforming viruses on cellular mutagenesis, genome stability, and cellular transformation. | it is estimated that 15% of all cancers are etiologically linked to viral infection. specific cancers including adult t-cell leukemia, hepatocellular carcinoma, and uterine cervical cancer are associated with infection by human t-cell leukemia virus type i, hepatitis b virus, and high-risk human papilloma virus, respectively. in these cancers, genomic instability, a hallmark of multistep cancers, has been explicitly linked to the expression of oncoproteins encoded by these viruses. this review d ... | 2005 | 15645440 |
| problems with using biomarkers as surrogate end points for cancer: a cautionary tale. | investigations employing surrogate cancer end points are especially attractive because they may be smaller, shorter, and cheaper than comparable studies with explicit cancer outcomes. for many potential surrogate end points--epithelial cell proliferation will be taken as an example--inferences are problematic because of the existence of alternative causal pathways to cancer that bypass the surrogate end point. evaluating potential surrogates requires information on the following three questions: ... | 2005 | 15648185 |
| the human papillomavirus e6 and e7 inducible oncogene, hwapl, exhibits potential as a therapeutic target. | here we show that human papillomavirus (hpv) e6 and e7 oncoproteins induce hwapl expression. in addition, small interfering rna (sirna) of hwapl suppressed the growth of tumours derived from siha cells in nude mice. thus, hwapl may be one of the effective targets of uterine cervical cancer therapy. | 2005 | 15655544 |
| imiquimod cream 5% for recalcitrant cutaneous warts in immunosuppressed individuals. | viral warts may cause significant morbidity in individuals unable to mount an adequate t-helper 1 cell-mediated immune response to human papillomavirus. imiquimod is a potent inducer of antiviral cytokine activity which has shown significant efficacy in the treatment of genital warts. similar efficacy in cutaneous warts is not yet established. | 2005 | 15656812 |
| bowen's disease on the sole: p16ink4a overexpression associated with human papillomavirus type 16. | we report a case of bowen's disease on the sole presenting clinically as an exophytic, blackish-grey, verrucous tumour, and showing human papillomavirus (hpv) type 16 on analysis with polymerase chain reaction. positive stains for hpv particles by immunohistochemical analysis were limited to several cell nuclei at the upper stratum malpighii. however, all the tumour cells in the epidermis exhibited strong and diffuse nuclear and cytoplasmic stains for the tumour suppressor protein p16ink4a. we s ... | 2005 | 15656821 |
| a study of the impact of adding hpv types to cervical cancer screening and triage tests. | use of human papillomavirus (hpv) testing in cervical cancer prevention is increasing rapidly. a dna test for 13 hpv types that can cause cervical cancer is approved in the united states for co-screening with cytology of women >or=30 years old and for triage of women of all ages with equivocal cytology. however, most infections with hpv are benign. we evaluated trade-offs between specificity and sensitivity for approximately 40 hpv types in predicting cervical intraepithelial neoplasia 3 and can ... | 2005 | 15657345 |
| human papillomavirus oncoprotein e7 targets the promyelocytic leukemia protein and circumvents cellular senescence via the rb and p53 tumor suppressor pathways. | cellular senescence can be triggered by a variety of signals, including loss of telomeric integrity or intense oncogenic signaling, and is considered a potent, natural tumor suppressor mechanism. previously, it was shown that the promyelocytic leukemia protein (pml) induces cellular senescence when overexpressed in primary human fibroblasts. the mechanism by which the pml iv isoform elicits this irreversible growth arrest is believed to involve activation of the tumor suppressor pathways p21/p53 ... | 2005 | 15657429 |
| operative treatment of cervical premalignant lesions and the presence of high-risk human papilloma virus as etiologic agent. | the conization as an excisional method is used as an operative treatment of high-risk premalignant cervical lesions. early detection and removal may stop the developing process that leads to invasive carcinoma. the study presents a group of 100 women, operated with "cold knife" conization during the year 2002 at the 1st operative oncologic department of the gynecology and obstetrician clinic - medical faculty, skopje. the operative material showed cin 2 in 2 and cin 3 in 31 women. in 7 of them, ... | 2004 | 15658576 |
| immune responses to human papillomavirus in genital tract of women with cervical cancer. | to address a question whether immune responses to hpv infection play a role in control of cervical cancer, we analyzed systemic and mucosal immune responses to hpv in women who underwent radical hysterectomy for cervical cancer (hcc) or loop conization due to cervical dysplasia (loop), or had hysterectomy for other reasons (hnn). | 2005 | 15661235 |
| testing positive for human papillomavirus in routine cervical screening: examination of psychosocial impact. | to examine the psychosocial impact of testing positive for high risk human papillomavirus (hpv) among women attending primary cervical screening. | 2004 | 15663132 |
| modification of professional antigen-presenting cells with small interfering rna in vivo to enhance cancer vaccine potency. | rna interference using small interfering rna (sirna) is an effective means of silencing gene expression in cells. intradermal administration of nucleic acids via gene gun represents an efficient method for delivering nucleic acids to professional antigen-presenting cells in vivo. in this study, we show that the coadministration of dna vaccines encoding human papillomavirus type 16 e7 with sirna targeting key proapoptotic proteins bak and bax prolongs the lives of antigen-expressing dendritic cel ... | 2005 | 15665308 |
| matrix metalloproteinase-2, squamous cell carcinoma antigen, and tissue polypeptide-specific antigen expression in egyptian patients with cervical carcinoma: relationship with prognosis. | matrix metalloproteinases (mmps), a family of proteolytic enzymes produced by both stromal and tumor cells, appear to have a key role in the events leading to local invasion and metastasis by malignant neoplasms. in the present study, we evaluated the role of mmp-2, squamous cell carcinoma antigen (scca), and tissue polypeptide - specific antigen (tps) in cervical neoplasia. using western blotting and enzyme immunoassay (eia), we analyzed 50 patients with cervical carcinoma (cc) and 25 normal co ... | 2004 | 15665394 |
| papillomavirus infection in rural women in southern india. | to investigate the prevalence of, and the risk factors for, cervical infection with 44 types of human papillomavirus (hpv) in a rural area in the dindigul district, tamil nadu, india, we interviewed and obtained cervical cell samples from 1891 married women aged 16-59 years. hpv prevalence was 16.9% overall and 14.0% among women without cervical abnormalities, or 17.7 and 15.2%, respectively, age-standardised to the world standard population. in all, 21.9% of infections involved more than one hp ... | 2005 | 15668709 |
| association of cottontail rabbit papillomavirus e6 oncoproteins with the hdlg/sap97 tumor suppressor. | papillomaviruses are small dna viruses that infect epithelial tissues and cause warts. human papillomavirus (hpv) infection is the primary risk factor for the development of cervical cancer. the e6 and e7 oncogenes are the only genes consistently expressed in hpv-positive cervical cancer cells. cottontail rabbit papillomavirus (crpv) induces papillomas and carcinomas on cottontail and domestic rabbits and provides an excellent animal model of hpv infection and vaccine development. crpv encodes t ... | 2005 | 15669058 |
| human papillomavirus (hpv) genotyping by hpv dna chip in cervical cancer and precancerous lesions. | the human papillomavirus (hpv) is a well-known cause of cervical cancer. hpv tests are used as an adjunct test to decrease the false-negative rate of cytological screening. however, attempts are being made to replace the cytological screening with hpv tests. therefore, this study was performed to examine the possibility of using hpv tests as screening test. | 2005 | 15670301 |
| cellular process classification of human papillomavirus-16-positive siha cervical carcinoma cell using gene ontology. | this study utilized mrna differential display and the gene ontology (go) analysis to characterize the multiple interactions of a number of genes involved in human papillomavirus (hpv)-16-induced cervical carcinogenesis. we used hpv-16-positive cervical cancer cell line (siha) and normal human keratinocyte cell line (hacat) as a control. each gene has several biological functions in the go, and hence, we chosen the several functions for each gene. and then, the specific functions were correlated ... | 2005 | 15670303 |
| polymorphism in the e6 gene of human papillomavirus type 16 in the cervical tissues of korean women. | the aim of this study was to identify sequence variants in the hpv 16 e6 gene in korean women and to examine the possible association between these sequence variants and cervical cancer development. we examined the hpv 16 dna of 215 patients with no cervical disease (ncd) (n = 105) or with cervical neoplasia (n = 110) [cervical intraepithelial neoplasia (cin), n = 61; invasive cervical carcinoma (icc), n = 49] using the nested polymerase chain reaction (pcr) and pcr-directed sequencing methods. ... | 2005 | 15670304 |
| results of a phase ii double-blinded randomized clinical trial of difluoromethylornithine for cervical intraepithelial neoplasia grades 2 to 3. | our purpose was to conduct a double-blinded randomized trial of difluoromethylornithine (dfmo) at 0.125, 0.5 gm/m2, versus placebo in the treatment of cervical intraepithelial neoplasia (cin) grades 2 to 3. a promising phase i study has shown histopathologic responses at these dose levels. | 2005 | 15671570 |
| genetic abnormalities and hpv status in cervical and vulvar squamous cell carcinomas. | cervical and vulvar cancers are diseases of the female lower genital tract, and high-risk human papillomavirus (hpv) infection is the most important risk factor for the development of both cancers. however, it is clear that additional genetic events are necessary for tumor progression, particularly in hpv-negative cases. we detected the presence of high-risk hpv16 and hpv18 genomes by gene-specific polymerase chain reaction and searched for common genetic imbalances by comparative genomic hybrid ... | 2005 | 15676146 |
| [papilloma virus infection in pretumor and tumor masses of the larynx]. | there has been recent evidence suggesting that papilloma virus infection is of no small importance in the pathogenesis of tumors of the head and neck. this study has involved a screening of the mucosa having laryngeal pretumors and tumors for papilloma virus infection by polymerase chain reaction and immunohistochemistry. specimens were studied in 130 patients. all the patients with laryngeal papillomatosis were found to have human papilloma virus (hpv) types 6 and 11. hpv-18 was detected in 6 ( ... | 2004 | 15678687 |
| genomic and proteomic expression patterns in hpv-16 e6 gene transfected stable human carcinoma cell lines. | cdna microarray and proteomics studies were performed to analyze the genomic and proteomic expression patterns in hpv-16 e6 gene transfected stable human carcinoma cell lines. among 1024 known genes and ests tested by cdna microarray, we found 50 upregulated and 35 downregulated genes in rc10.1 hpv-16 e6 transfected human colon adenocarcinoma cells compared to rko cells, and 27 upregulated and 43 downregulated genes in a549e6 hpv-16 e6 transfected human lung adenocarcinoma cells compared to a549 ... | 2004 | 15684709 |
| hpv16 semiquantitative viral load and serologic biomarkers in oral and oropharyngeal squamous cell carcinomas. | a considerable subset of oropharyngeal squamous cell carcinomas (sccs) are positive for human papillomavirus (hpv); however, delineating etiologically-associated hpv infections from sccs with concurrent hpv infection unrelated to tumorigenesis is challenging. viral load assessment in biopsy specimens may help facilitate such differentiation. hpv16 viral load and serologic markers were assessed among oral and oropharyngeal cases from a multinational study conducted by the international agency for ... | 2005 | 15688391 |
| [hpv and cancer]. | human papillomavirus (hpv) has been largely demonstrated involved in the pathogenesis of several intraepithelial lesions and cancers. the role of hpv in the carcinogenesis of intraepithelial and invasive anogenital lesions is currently well established, characterized by integrated dna hpv inside the lesions. hpv genotypes are classified according to their risk of oncogenesis and hpv16 remains the most common and higher oncogenic types. hiv-infected patients have a higher rate of hpv infection wi ... | 2005 | 15689325 |
| human papillomavirus infection in egyptian esophageal carcinoma: correlation with p53, p21, mdm2, c-erbb2 and impact on survival. | the etiological role of human papillomavirus (hpv) in esophageal carcinoma (ec) in relation to p53, mdm2, p21(waf), c-erbb2 and the overall survival (os) rate was investigated. tumor and normal tissues from 50 ec were evaluated by polymerase chain reaction and innolipa for hpv. single strand conformation polymorphism/sequencing were used to detect p53 gene mutations. immunohistochemistry was performed to determine p53, mdm2, p21(waf)and c-erbb2 expression. human papillomavirus was detected in 54 ... | 2005 | 15693850 |
| response to "primary cervical cancer screening by self-sampling of human papillomavirus dna in internal medicine outpatient clinics", by dannecker et al. (ann oncol 2004; 15: 863-869) and "histopathological validation of the sentinel node concept in cervical cancer", by barranger et al. (ann oncol 2004; 15: 870-874): dna microarrays will be instrumental in the future diagnosis of cervical dysplasia and neoplasia. | 2005 | 15695502 | |
| caspase-3-dependent apoptosis in cardiac myxoma: not associated with human papillomavirus or epstein-barr virus. | cardiac myxoma is the most common tumor of the heart, has a variable clinical presentation and immunohistochemical profile. viral infections, such as herpes simplex virus, human papillomavirus (hpv), and epstein-barr virus (ebv), may play an important role in the causes of cardiac myxoma. this investigation will demonstrate caspase-3-dependent apoptosis in cardiac myxoma without hpv or ebv infection. this study included 15 patients with cardiac myxoma, who were treated with surgical excision of ... | 2005 | 15696123 |
| re: munoz et al., "against which human papillomavirus types shall we vaccinate and screen? the international perspective." int j cancer 2004;111:278-85. | 2005 | 15704103 | |
| heterologous papillomavirus virus-like particles and human papillomavirus virus-like particle immune complexes activate human langerhans cells. | chimeric human papillomavirus virus-like particles (hpv cvlp) are currently being explored as a therapeutic vaccination strategy against cervical cancer. hpv cvlp are being explored as a result of their interaction with and activation of dendritic cells, a potent antigen-presenting cell. however langerhans cells, another type of antigen-presenting cell, can interact with hpv cvlp especially during mucosal routes of vaccine administration. langerhans cells are not activated by hpv cvlp, utilize a ... | 2005 | 15705478 |
| detection and genotyping of human papillomavirus in cervical samples from italian patients. | human papillomaviruses (hpvs) are etiological agents of cervical cancer. in order to assess the epidemiological incidence and frequency of different hpv types, we applied a polymerase chain reaction (pcr)-direct sequencing approach based on the use of my09/my11 primers as compared to hybrid capture assay. cervical samples were taken from 1,500 women, both with normal and abnormal cytological smears, and we found an incidence of 6.6% of hpv infection in brescia. overall, 97 samples tested hpv-pos ... | 2005 | 15714493 |
| human papilloma virus in oral squamous cell carcinoma in a mexican population. | to determine the human papilloma virus (hpv) infection in oral cancer and its association with smoking and drinking habits. | 2005 | 15716837 |
| targeted therapy for targeted patients: trastuzumab in adjuvant treatment of non-small-cell lung cancer. | 2005 | 15718338 | |
| cd4+ t cell immunity against the human papillomavirus-18 e6 transforming protein in healthy donors: identification of promiscuous naturally processed epitopes. | infection by 'high-risk' human papillomaviruses (hpv) is associated with the development of neoplastic lesions. hpv-18 is responsible for a very aggressive form of cancer and poor survival. as for other hpv types, immune surveillance has probably a role in the control of the infection. however, very little is known on hpv-18 immunogenicity. cd4(+) t cells from 16 healthy donors were tested ex vivo for reactivity to synthetic peptides corresponding to 3 sequences on the hpv-18 e6 transforming pro ... | 2005 | 15719368 |
| plasmacytoid dendritic cells are present in cervical carcinoma and become activated by human papillomavirus type 16 virus-like particles. | plasmacytoid dendritic cells (pdc) play an important role in the innate immune response to viral infections through the secretion of high levels of ifnalpha. we investigated whether pdc play a role in human papillomavirus (hpv) associated cervical carcinoma. | 2005 | 15721448 |
| synchronous and metachronous endocervical and ovarian neoplasms: evidence supporting interpretation of the ovarian neoplasms as metastatic endocervical adenocarcinomas simulating primary ovarian surface epithelial neoplasms. | the vast majority of endocervical adenocarcinomas are high-risk human papillomavirus (hpv)-related neoplasms, characterized by p16 expression and frequent loss of hormone receptor expression, which infrequently metastasize to the ovaries. we report 10 cases of endocervical adenocarcinomas with ovarian metastases in which the ovarian tumors simulated primary ovarian surface epithelial neoplasms. the presence of hpv dna was assessed to determine whether the ovarian neoplasms were metastases or ind ... | 2005 | 15725796 |
| genetic analysis of the human papillomavirus type 31 differentiation-dependent late promoter. | human papillomaviruses infect stratifying squamous epithelia, causing benign and malignant lesions. upon differentiation of the host keratinocyte, the virus undergoes a dramatic increase in both dna replication and transcription from the late promoter, leading to expression of late genes and virion morphogenesis. in human papillomavirus type 31 (hpv31), the late promoter is designated p742 and includes multiple start sites embedded within the e7 gene. in this report, we mapped viral dna elements ... | 2005 | 15731225 |
| medication use, medical conditions, and the risk of human papillomavirus infection and subsequent cervical intraepithelial neoplasia 3 among women with mild cytologic abnormalities. | 2005 | 15734987 | |
| generation and molecular characterization of head and neck squamous cell lines of fanconi anemia patients. | patients with fanconi anemia (fa) are prone to develop malignancies at an early age. besides hematologic malignancies, squamous cell carcinomas in the anogenital region and head and neck are also frequently found in these patients. the aim of this study was to generate a panel of head and neck squamous cell carcinoma (hnscc) cell lines and xenografts of fa hnscc, and to characterize these cell lines in comparison with a panel of seven cell lines from patients with sporadic hnscc. analyses have b ... | 2005 | 15735012 |
| development of skin tumors in mice transgenic for early genes of human papillomavirus type 8. | the cutaneous human papillomavirus (hpv) 8 is clearly involved in skin cancer development in epidermodysplasia verruciformis patients and its early genes e2, e6, and e7 have been implicated in cell transformation in vitro. to examine the functions of these genes in vivo we integrated the complete early region of hpv8 into the genome of dba/bl6 mice. to target their expression to the basal layer of the squamous epithelia the transgenes were put under the control of the keratin-14 promoter. transg ... | 2005 | 15735026 |
| hpv16 e5 protein disrupts the c-cbl-egfr interaction and egfr ubiquitination in human foreskin keratinocytes. | the e5 protein of human papillomavirus type 16 (hpv16) is a small hydrophobic protein, which localizes to the cell membrane, golgi apparatus and endosomes. hpv16 e5 enhances the activation of the epidermal growth factor (egfr). the activated egfr is downregulated through the endocytic pathway, where e5 has been shown to inhibit endosomal acidification and trafficking. ubiquitination of the activated egfr plays a role in this downregulation. c-cbl is a ubiquitin ligase that associates with the ac ... | 2005 | 15735736 |
| trail is a key target in s-phase slowing-dependent apoptosis induced by interferon-beta in cervical carcinoma cells. | interferon (ifn)-beta induces s-phase slowing and apoptosis in human papilloma virus (hpv)-positive cervical carcinoma cell line me-180. here, we show that apoptosis is a consequence of the s-phase lengthening imposed by ifn-beta, demonstrating the functional correlation between s-phase alteration and apoptosis induction. in me-180 cells, where p53 function is inhibited by hpv e6 oncoprotein, ifn-beta effects on cell cycle and apoptosis occur independently of p53. the apoptosis due to ifn-beta i ... | 2005 | 15735750 |
| changing patterns of sexually transmitted infections in india. | sexually transmitted infections (stis) are more dynamic than other diseases prevailing in the community. their epidemiological profile varies from country to country and from one region to another within a country, depending upon ethnographic, demographic, socioeconomic and health factors. the clinical pattern is also a result of the interaction among pathogens, the behaviours that transmit them and the effectiveness of preventive and control interventions. we reviewed the changing patterns of d ... | 2004 | 15736552 |
| verucciform xanthoma of the penis not associated with human papillomavirus infection. | verruciform xanthoma (vx) is a rare lesion with a predilection for oral mucosa. only 16 cases of vx of the penis have been reported. histologically, vx lesions in different locations are identical; however, the etiology is controversial. previous studies have reported the presence of human papillomavirus (hpv) in vx of the skin. the purpose of this study was to determine whether hpv is a causative agent in this rare case of vx of the penis. microscopically, the lesion demonstrated prominent verr ... | 2005 | 15737058 |
| regulation of apoptosis by the papillomavirus e6 oncogene. | infection with human papillomaviruses is strongly associated with the development of multiple cancers including esophageal squamous cell carcinoma. the hpv e6 gene is essential for the oncogenic potential of hpv. the regulation of apoptosis by oncogene has been related to carcinogenesis closely; therefore, the modulation of e6 on cellular apoptosis has become a hot research topic recently. inactivation of the pro-apoptotic tumor suppressor p53 by e6 is an important mechanism by which e6 promotes ... | 2005 | 15742391 |
| abstracts of the 24th annual convention of indian association for cancer research and international symposium on human papillomavirus and cervical cancer. february 9-12, 2005, noida, india. | 2005 | 15744933 | |
| human papilloma virus, papanicolaou smears, and the college female. | this article discusses human papilloma virus (hpv), papanicolaou smears and the rational for new screening guidelines. | 2005 | 15748929 |
| genitourinary issues in the male college student: a case-based approach. | five percent of all ambulatory visits by men 18 years of age or older include genitourinary symptoms as a reason for the visit. in this article, using typical, unusual, or otherwise instructive cases, the authors review a select group of genitourinary issues in the college-age male. warts (human papilloma virus), is the most common sexually transmitted infection, and it may mimic other disease. testicular cancer is one of the most serious diseases to confront health care providers. varicoceles a ... | 2005 | 15748931 |
| the epidemiology of human papillomavirus infections. | infection with oncogenic human papillomavirus (hpv) types is a necessary cause of cervical cancer, the second most frequently occurring cancer in women worldwide. rates of acquisition of hpv are high, particularly among sexually active young adults. reported estimates of incident hpv infection among initially negative women have reached as high as 60% over a 5-year follow-up period. in this article, we review the epidemiology of hpv infection. in addition to estimates of disease frequency, we hi ... | 2005 | 15753008 |
| hpv-mediated transformation of the anogenital tract. | infection with high-risk human papillomavirus (hr-hpv) has been associated with intraepithelial neoplasia and carcinomas at various sites of the anogenital tract, including the cervix, vulva, vagina, penis and anus. although hr-hpv is a necessary cause for cervical cancer, the majority of anal cancers and a subset of cancers at other genital sites, additional (epi)genetic events are required for malignant transformation. hpv-mediated transformation of human epithelial cells has been recognized a ... | 2005 | 15753009 |
| human papillomavirus in squamous cell carcinoma of esophagus in a high-risk population. | to investigate the relation of human papillomavirus (hpv) and esophageal squamous cell carcinoma (escc) in iranian patients as compared to normal controls. | 2005 | 15754405 |