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protein immunization induces memory cd4+ t cells that lack th lineage commitment.acute viral infection generates lineage-committed th1 and t follicular helper (tfh) memory cells that recall their lineage-specific functions following secondary challenge with virus. however, the lineage commitment of effector and memory th cells in vivo following protein vaccination is poorly understood. in this study, we analyzed effector and memory cd4+ t cell differentiation in mice (mus musculus) following adjuvanted glycoprotein immunization compared with acute lymphocytic choriomeningiti ...202134380649
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