Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| exposing ferrets to cigarette smoke and a pharmacological dose of beta-carotene supplementation enhance in vitro retinoic acid catabolism in lungs via induction of cytochrome p450 enzymes. | in our previous studies, we found lower levels of retinoic acid (ra) in the lungs of ferrets exposed to cigarette smoke and/or a pharmacological dose of beta-carotene. to determine whether this is involved in excessive catabolism of ra via cytochrome p450 (cyp) induction, we carried out in vitro incubations of ra with the lung microsomal fractions of ferrets with or without cyp inhibitors and antibodies against cyp. the polar metabolites (4-oxo-ra and 18-hydroxy-ra) of ra metabolism after the in ... | 2003 | 12514286 |
| spatiotemporal patterns of excitation and inhibition evoked by the horizontal network in layer 2/3 of ferret visual cortex. | the horizontal network in visual cortex layer 2/3 is implicated in numerous psychophysical and physiological properties. to investigate the spatial and temporal distribution of excitation and inhibition evoked by this network, we used voltage-sensitive dyes to image the responses to focal electrical stimulation in tangential slices of ferret visual cortex layer 2/3. the resulting optical patterns included a diffuse zone of activation near the stimulation site and numerous ovoid domains throughou ... | 2003 | 12522196 |
| recruitment of local inhibitory networks by horizontal connections in layer 2/3 of ferret visual cortex. | to investigate how neurons in cortical layer 2/3 integrate horizontal inputs arising from widely distributed sites, we combined intracellular recording and voltage-sensitive dye imaging to visualize the spatiotemporal dynamics of neuronal activity evoked by electrical stimulation of multiple sites in visual cortex. individual stimuli evoked characteristic patterns of optical activity, while delivering stimuli at multiple sites generated interacting patterns in the regions of overlap. we observed ... | 2003 | 12522197 |
| species comparison of methemoglobin reductase. | methemoglobin (mhb) formation is effective in treating cyanide (cn) poisoning. endogenous activity of the enzyme mhb reductase (mr) reflects the capacity to reduce mhb and thus represents a key factor for evaluating anti-cn efficacy of mhb formers. mr activity was measured in whole blood of nine animal species and was compared with human mr activity. the animals in this comparative study included seven nonhuman primate (nhp) species, the beagle dog, and the ferret. although exhibiting higher mr ... | 2003 | 12524477 |
| cryptococcosis in ferrets: a diverse spectrum of clinical disease. | cryptococcosis was diagnosed in seven ferrets (five from australia; two from western canada) displaying a wide range of clinical signs. two of the ferrets lived together. one (5-years-old) had cryptococcal rhinitis and presented when the infection spread to the nasal bridge. its sibling developed cryptococcal abscessation of the right retropharyngeal lymph node 12 months later, soon after developing a severe skin condition. dna fingerprinting and microsatellite analysis demonstrated that the two ... | 2002 | 12537139 |
| the effect of electroacupuncture as an adjunct on cyclophosphamide-induced emesis in ferrets. | the effect of electroacupuncture (ea) on cyclophosphamide-induced emesis in ferrets was studied at acupuncture point neiguan (p6) with various electrical stimulation parameters (5-100 hz, 1.5-3 v, 5-20 min, n=6/group). the combination therapy of ea (100 hz, 1.5 v and 10 min) with the lower doses of ondansetron (0.04 mg/kg), droperidol (0.25 mg/kg) and metoclopramide (2.24 mg/kg) significantly reduced the total number of emetic episodes by 52%, 36% and 73%, respectively, as well as the number of ... | 2003 | 12543236 |
| mechanisms of submucosal gland morphogenesis in the airway. | submucosal glands (smgs) are thought to play an important role in the pathogenesis of a number of hypersecretory lung diseases including cystic fibrosis, asthma, and chronic bronchitis. in such diseases, severe smg hypertrophy and hyperplasia is characteristic of disease progression. our laboratory has focused efforts on defining both the mechanism of smg morphogenesis and the identification of smg stem cells. to this end, we have identified a transcription factor (lef1) that is temporally and s ... | 2002 | 12568487 |
| fast rhythmic bursting can be induced in layer 2/3 cortical neurons by enhancing persistent na+ conductance or by blocking bk channels. | fast rhythmic bursting (or "chattering") is a firing pattern exhibited by selected neocortical neurons in cats in vivo and in slices of adult ferret and cat brain. fast rhythmic bursting (frb) has been recorded in certain superficial and deep principal neurons and in aspiny presumed local circuit neurons; it can be evoked by depolarizing currents or by sensory stimulation and has been proposed to depend on a persistent g(na) that causes spike depolarizing afterpotentials. we constructed a multic ... | 2003 | 12574468 |
| receptive fields and response properties of neurons in layer 4 of ferret visual cortex. | the ferret has become a model animal for studies exploring the development of the visual system. however, little is known about the receptive-field structure and response properties of neurons in the adult visual cortex of the ferret. we performed single-unit recordings from neurons in layer 4 of adult ferret primary visual cortex to determine the receptive-field structure and visual-response properties of individual neurons. in particular, we asked what is the spatiotemporal structure of recept ... | 2003 | 12574476 |
| a radialization factor in normal cortical plate restores disorganized radial glia and disrupted migration in a model of cortical dysplasia. | treatment of pregnant ferrets on embryonic day 24 (e24) with the antimitotic methylazoxy methanol (mam) leads to a specific constellation of effects in newborn kits, which include a very thin and poorly laminated neocortex, disruption of radial glial cell morphology with early differentiation into astrocytes, and abnormal positioning of cajal-retzius cells. we suggest that mam treatment on e24 results in this model of cortical dysplasia by eliminating a population of cells that produce a factor ... | 2003 | 12581165 |
| synthesis and structure-affinity relationships of novel n-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotonin 5-ht3 and dopamine d2 receptor antagonistic activity. | a structurally original series of n-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides derived from the corresponding benzamide 5 were prepared and evaluated for their binding affinity for the dopamine d(2) and serotonin 5-ht(3) receptors using rat striatum and rat cortical membrane, respectively. many of the synthesized pyridine-3-carboxamides exhibited nanomolar binding affinity for the serotonin 5-ht(3) receptor along with moderate to high binding affinity for the dopamine d ... | 2003 | 12593651 |
| coding of natural scenes in primary visual cortex. | natural scene coding in ferret visual cortex was investigated using a new technique for multi-site recording of neuronal activity from the cortical surface. surface recordings accurately reflected radially aligned layer 2/3 activity. at individual sites, evoked activity to natural scenes was weakly correlated with the local image contrast structure falling within the cells' classical receptive field. however, a population code, derived from activity integrated across cortical sites having retino ... | 2003 | 12597866 |
| pathogenicity and antigenicity of a new influenza a (h5n1) virus isolated from duck meat. | avian influenza a viruses are the ancestral origin of all human influenza viruses. the outbreak of highly pathogenic (hp) avian h5n1 in hong kong in 1997 highlighted the potential of these viruses to infect and cause severe disease in humans. since 1999, hp h5n1 viruses were isolated several times from domestic poultry in asia. in 2001, a hp h5n1 virus, a/duck/anyang/avl-1/2001 (dk/anyang), was isolated from imported frozen duck meat in korea. because of this novel source of hp h5n1 virus isolat ... | 2003 | 12601764 |
| differential functional properties of calmodulin-dependent protein kinase iigamma variants isolated from smooth muscle. | six variants of calmodulin-dependent protein kinase iigamma were isolated from a ferret-aorta smooth-muscle cdna library. variant g-2 is generated by a novel alternative polyadenylation, utilizing a site contained in an intron. the last 77 residues of the association domain are replaced with 99 residues of a unique sequence containing src homology 3-domain-binding motifs, which alter catalytic activity. variant c-2 has an eight-residue deletion in an atp-binding motif and does not autophosphoryl ... | 2003 | 12603201 |
| developmental capacity of ferret embryos by nuclear transfer using g0/g1-phase fetal fibroblasts. | with the ultimate goal of establishing experimental protocols necessary for cloning ferrets, the present study has established parameters for the reconstruction of ferret embryos by nuclear transfer (nt) using g0/g1-phase donor fetal fibroblasts. cumulus-oocyte complexes were harvested from superovulated ferrets and cultured in maturation medium for 24 h. matured oocytes were then enucleated and injected with the fibroblast nuclei derived from 14-16-h serum-starved cells. reconstructed embryos w ... | 2003 | 12606336 |
| activity-dependent change in the protein level of brain-derived neurotrophic factor but no change in other neurotrophins in the visual cortex of young and adult ferrets. | neurotrophins are suggested to play a role in activity-dependent plasticity of visual cortex during the critical period of postnatal development. thus, the concentration of neurotrophins in the cortex is expected to change with development and/or with alteration in neuronal activities. to test this, we measured protein levels of nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4/5 in visual cortex of young (postnatal day 38-46, at the peak of the critical p ... | 2003 | 12614676 |
| ferret urogenital diseases. | improved nutrition and client education have decreased the incidence of certain urinary tract diseases in ferrets. early neutering programs at commercial breeding farms in the united states have also led to a marked decrease in the incidence of reproductive tract disease, especially estrogen-induced bone marrow suppression. however, the increased incidence of adrenal disease and its secondary effects on reproductive and associated urinary tract tissue presents an ongoing challenge for the clinic ... | 2003 | 12616836 |
| quantitative measurement of afferent layers in the ferret inferior colliculus: dnll projections to sublayers. | in the central nucleus of the inferior colliculus (ic), afferent projections are aligned with dendritic arbors of disk-shaped cells, forming fibrodendritic layers. one feature that may serve as a guide for study of the intrinsic organization of the ic layers is the segregation of certain inputs to bands and patches within the layers of the central nucleus. in this study, we used phaseolus leucoagglutinin as an anterograde tracer to examine the projections from the dorsal nucleus of the lateral l ... | 2003 | 12618315 |
| serotonin (5-hydroxytryptamine) glucuronidation in vitro: assay development, human liver microsome activities and species differences. | 1. the main purpose was to develop a high-performance liquid chromatography (hplc)-based method to assay serotonin glucuronidation activity using liver microsomal fractions. application of this method was then demonstrated by determining serotonin udp-glucuronosyltransferase (ugt) enzyme kinetics using human liver microsomes and recombinant human ugt1a6. interspecies differences were also evaluated using liver microsomes from 10 different mammalian species. 2. incubation of liver microsomes with ... | 2003 | 12623759 |
| different inhibitory synaptic input patterns in excitatory and inhibitory layer 4 neurons of ferret visual cortex. | the synaptic mechanisms underlying the generation of orientation and direction selectivity in layer 4 of the primary visual cortex are still largely unclear. previous in vivo work has shown that intra-cortical inhibition plays a major role in generating the properties of orientation and direction selectivity. excitatory and inhibitory cortical neurons differ in their receptive field properties: excitatory neurons tend to be orientation- and direction-selective, inhibitory neurons tend to be orie ... | 2003 | 12631564 |
| identification of genotypes of cryptosporidium parvum isolates from ferrets in japan. | recent molecular studies show that cryptosporidium parvum is composed of at least eight genotypes including zoonotic genotypes. therefore, it is important to screen the genotypes of the isolates harbored in animals for the control of human cryptosporidiosis. the ferret is a popular pet, but also a reservoir of cryptosporidium. since the infectivity of zoonotic genotypes in ferrets remains unclear, there is a possibility these hosts harbor zoonotic genotypes. in the present study, we examined the ... | 2003 | 12632159 |
| adrenal cortical carcinomas with myxoid differentiation in the domestic ferret (mustela putorius furo). | a total of 15 adrenocortical carcinomas with myxoid differentiation from 15 ferrets were evaluated in this retrospective study. six of these ferrets (40%) either were euthanatized or died due to invasive and/or metastatic disease. the myxoid component was a variable part (between 5% and 95%) of the adrenal cortical neoplasm and consisted of sheets and cords of small, polygonal neoplastic cells that formed lumenlike spaces. such spaces contained a variable amount of alcian blue (ph 2.5)-positive ... | 2003 | 12637752 |
| substituted aminopyridines as potent and selective phosphodiesterase-4 inhibitors. | the synthesis and the biological evaluation of new potent phosphodiesterase type 4 (pde4) inhibitors are presented. this new series was elaborated by replacement of the metabolically resistant phenyl hexafluorocarbinol of l-791,943 (1) by a substituted aminopyridine residue. the structure-activity relationship of n-substitution on 3 led to the identification of (-)-3n which exhibited a good pde4 inhibitor activity (hwb-tnfalpha=0.12 microm) and an improved pharmacokinetic profile over l-791,943 ... | 2003 | 12639571 |
| visual field defects in albino ferrets (mustela putorius furo). | the extent of the horizontal visual field was determined behaviourally in 4 pigmented and 5 albino ferrets (mustela putorius furo, carnivora, mammalia) using perimetry. during binocular vision, all pigmented and three albino ferrets responded equally well to stimuli presented anywhere along the horizontal perimeter in the central 180 degrees of the visual field. the remaining two albinos had a visual field defect in the right hemifield (>30 degrees eccentricity). during monocular vision, a signi ... | 2003 | 12639605 |
| pharmacological profile of as-9705, a novel benzotriazolecarboxamide derivative, as a gastroprokinetic agent with potent anti-emetic activity. | the pharmacological profile of as-9705 ((r)-n-(1-ethyl-1h-hexahydroazepin-3- yl)-6- methoxy-1h-benzotriazole-5-carboxamide fumarate monohydrate, cas 219622-61-4), a novel gastroprokinetic agent with potent anti-emetic activity, was investigated in the present study. as-9705 inhibited [3h]spiperone binding to human dopamine d2.long receptors, and [3h]r(+)-7-oh-dpat binding to human dopamine d3 receptors (ic50 values of 58.5 +/- 14.0 and 60.8 +/- 7.8 (nmol/l), respectively) and had negligible affi ... | 2003 | 12642965 |
| adaptation and temporal decorrelation by single neurons in the primary visual cortex. | limiting redundancy in the real-world sensory inputs is of obvious benefit for efficient neural coding, but little is known about how this may be accomplished by biophysical neural mechanisms. one possible cellular mechanism is through adaptation to relatively constant inputs. recent investigations in primary visual (v1) cortical neurons have demonstrated that adaptation to prolonged changes in stimulus contrast is mediated in part through intrinsic ionic currents, a ca2+-activated k+ current (i ... | 2003 | 12649312 |
| cdna and deduced amino acid sequences of ferret preproendothelin-2 and phylogenetic analysis. | ferret preproendothelin-2 (ppet2) cdna was cloned from intestinal tissue by reverse transcription-polymerase chain reaction (rt-pcr) in conjunction with 5'- and 3'-rapid amplification of cdna ends (race). the cdna comprises 1230 bp, excluding the poly(a) tail, and has 534 bp of open reading frame encoding a putative polypeptide of 178 residues, in which a 21-amino acid mature endothelin-2 (et2) peptide as well as a 24-amino acid putative signal peptide and a 16-amino acid et2-like peptide were f ... | 2002 | 12652909 |
| neutralizing epitopes specific for influenza b virus yamagata group strains are in the 'loop'. | to study the neutralizing epitopes of influenza b virus yamagata group strains, two monoclonal antibodies (mabs) were used to select escape mutants of the virus. mabs 5h4 and 3a12 were found to react with b/yamagata group strains in haemagglutination inhibition and neutralization tests; no reactivity with b/victoria group strains was observed. most of the mutants reacted poorly to polyclonal ferret antibody against the 1998 isolate. analysis of the deduced amino acid sequences identified a singl ... | 2003 | 12655076 |
| large granular lymphocyte leukemia in a ferret. | 1995 | 12664438 | |
| pharmacology of a new cyclic nucleotide phosphodiesterase type 4 inhibitor, v11294. | v11294 is a new cyclic nucleotide phosphodiesterase type 4 (pde4) inhibitor of the rolipram class. in this report we present the pharmacological profile of v11294. v11294 inhibited pde4 isolated from human lung with ic(50) 405 nm, compared to 3700 nm for rolipram. in contrast, v11294 inhibition of human pde3 and pde5 occurred only at concentrations greater than 100,000 nm. like rolipram, v11294 inhibited pde4d more potently than other pde4 subtypes. v11294, when incubated with human anticoagulat ... | 2003 | 12670778 |
| cytological diagnosis of chordoma of the tail in a ferret. | 1992 | 12671792 | |
| action of metyrapone and tetracosactrin to modify cisplatin-induced acute and delayed emesis in the ferret. | cisplatin 5 mg/kg, i.p., induced an acute (day 1) and delayed (days 2 and 3) emetic response in the ferret that was used to investigate the potential anti-emetic activity of metyrapone and tetracosactrin and their potential interaction. the 11beta-hydroxylase enzymes inhibitor metyrapone 10-30 mg/kg, i.p., dose dependently potentiated the acute cisplatin-induce retching+vomiting response by up to 219% at the highest dose (p<0.001) but failed to affect significantly delayed emesis (p>0.05). the a ... | 2003 | 12679153 |
| the histological appearances of nissen-type fundoplication in the ferret. | nissen fundoplication is of proven effectiveness in the surgical control of gastro-oesophageal reflux. however, our understanding of the effects of fundoplication upon foregut physiology is incomplete and post-operative symptoms are often poorly understood. this experimental study aimed systematically to characterize the tissue response to fundoplication in an animal model, to improve understanding of the effects of anti-reflux surgery upon foregut physiology. nissen-type fundoplication was perf ... | 2003 | 12680911 |
| evaluation of sensitivity and specificity of cytologic examination: 269 cases (1999-2000). | to determine sensitivity and specificity of cytologic examination used in a clinical setting. | 2003 | 12685787 |
| developmental regulation of plasticity in the forepaw representation of ferret somatosensory cortex. | this study characterized the spatiotemporal responses in ferret somatosensory cortex after sensory deprivation at different phases of cortical development. we hypothesized that cortical responses to stimulation of intact superficial radial nerve in adults will vary systematically according to maturation of thalamocortical relationships at the time of an ulnar nerve transection. depending on the age of the animal at the time of the lesion, we found differential effects on the spatial distribution ... | 2003 | 12686585 |
| spectral properties and retinal distribution of ferret cones. | the spectral mechanisms of the ferret (mustela putorious furo) were studied with electroretinogram (erg) flicker photometry. variations in adaptation state and flicker rate were used to define corneally based spectral sensitivities for the three classes of receptor present in the retina of this mustelid-rods (lambdamax = 505 nm), s cones (430 nm), and l cones (558 nm). the retinal distributions of the two classes of cone were determined using opsin antibody labeling. ferret retinas contain a tot ... | 2003 | 12699079 |
| modeling individual differences in ferret external ear transfer functions. | individual variations in head and outer ear size, as well as growth of these structures during development, can markedly alter the values of the binaural and monaural cues which form the basis for auditory localization. this study investigated individual differences in the directional component of the head-related transfer function of both adult and juvenile ferrets. in line with previous studies in humans and cats, intersubject spectral differences were found to be reduced by scaling one of the ... | 2003 | 12703713 |
| failure of surface ring mutant strains of helicobacter mustelae to persistently infect the ferret stomach. | helicobacter mustelae, the gastric pathogen of ferrets, produces an array of surface ring structures which have not been described for any other member of the genus helicobacter, including h. pylori. the unique ring structures are composed of a protein named hsr. to investigate whether the hsr rings are important for colonization of the ferret stomach, ferrets specific pathogen free for h. mustelae were inoculated with an hsr-deficient mutant strain or the wild-type h. mustelae strain. quantitat ... | 2003 | 12704104 |
| suspected pseudohypoparathyroidism in a domestic ferret. | a 1.5-year-old ferret examined because of seizures was found to have low serum calcium, high serum phosphorus, and extremely high serum parathyroid hormone concentrations. common causes of these abnormalities, including nutritional secondary hyperparathyroidism, chronic renal secondary hyperparathyroidism, tumor lysis syndrome, and hypomagnesemia, were ruled out, and a tentative diagnosis of pseudohypoparathyroidism was made. pseudohypoparathyroidism is a hereditary condition in people that, to ... | 2003 | 12710772 |
| upregulation of calretinin immunostaining in the ferret inferior colliculus after cochlear ablation. | in many systems, including ascending auditory pathways, calcium-binding proteins are markers of specific neuronal circuits. previous studies suggest that calretinin immunostaining may be a specific marker for circuits in the inferior colliculus (ic) that code timing information. we undertook experiments to determine the changes in calretinin immunostaining in the ic that take place in response to cochlear ablation. cochlear ablation was performed unilaterally in ferrets just after hearing onset. ... | 2003 | 12717716 |
| the normal upper gastrointestinal examination in the ferret. | upper gastrointestinal examinations were performed in 11 unsedated ferrets and 4 ferrets sedated with ketamine and diazepam. each animal received a 8-13 ml/kg body weight dosage of barium liquid (30% weight:volume). radiographs were made immediately and at 5, 10, 20, 40, 60, 90, 120 and 150 min (mins) after the barium was administered. gastric emptying began immediately. mean total gastric emptying was longer in sedated ferrets (130 +/- 40 min versus 75 +/- 54 min); however, this difference was ... | 2003 | 12718350 |
| healing and feeling: the clinical ontology of emotion. | in the clinical setting, not enough attention is paid to the role that emotion plays. it is at worst ignored or avoided, isolating those who are suffering, at best treated as something to help another to endure. this is the result, in part, of an impoverished idea that views emotion as mere feelings. however, emotions are not just feelings, they are cognitive. if we look beneath the surface, emotions can provide information about values and beliefs, some of which may be false or unreasonable. wh ... | 2003 | 12722729 |
| evaluation of oral and subcutaneous delivery of an experimental canarypox recombinant canine distemper vaccine in the siberian polecat (mustela eversmanni). | we assessed the safety and efficacy of an experimental canarypox-vectored recombinant canine distemper virus (cdv) subunit vaccine in the siberian polecat (mustela eversmanni), a close relative of the black-footed ferret, (m. nigripes), an endangered species that is highly susceptible to the virus. siberian polecats were randomized into six treatment groups. recombinant canine distemper vaccine was administered s.c. at three dose levels (10(4.5), 10(5.0), and 10(5.5) plaque-forming units [pfu] p ... | 2003 | 12723797 |
| nitric oxide differentially modulates on and off responses of retinal ganglion cells. | several lines of evidence suggest that nitric oxide (no) can regulate diverse retinal functions, but whether this gas is capable of modulating the visual responses of retinal output neurons has not been established. in the present study the effects of no on rod-driven responses of retinal ganglion cells were tested by making whole cell patch-clamp recordings from morphologically identified ganglion cells in the isolated ferret retina. bath application of l-arginine, the substrate of nitric oxide ... | 2003 | 12724368 |
| histology and immunohistochemistry of seven ferret vaccination-site fibrosarcomas. | the anatomical location, histology, and immunohistochemistry of 10 ferret dermal and subcutaneous fibrosarcomas were examined. seven of the 10 tumors were from locations used for vaccination. all fibrosarcomas contained spindle-shaped cells surrounded by variable quantities of connective tissue stroma. however, vaccination-site fibrosarcomas (vsfs) subjectively contained a higher degree of cellular pleomorphism. multinucleated cells were present in three of seven vsfs but not in any of the nonva ... | 2003 | 12724570 |
| relay of visual information to the lateral geniculate nucleus and the visual cortex in albino ferrets. | the abnormal organization of the central visual pathways in the albino ferret has been characterized anatomically and physiologically. recordings in dorsal lateral geniculate nucleus of the albino ferret show that lamina a1, which receives an aberrant projection from the contralateral eye, contains an extensive representation of the ipsilateral visual hemifield with receptive fields located up to 35 degrees from the vertical meridian. this is not the case in pigmented ferrets, for which the vast ... | 2003 | 12724839 |
| substance p released from intrinsic airway neurons contributes to ozone-enhanced airway hyperresponsiveness in ferret trachea. | exposure to ozone (o3) induces airway hyperresponsiveness mediated partly through the release of substance p (sp) from nerve terminals in the airway wall. although substantial evidence suggests that sp is released by sensory nerves, sp is also present in neurons of airway ganglia. the purpose of this study was to investigate the role of intrinsic airway neurons in o3-enhanced airway responsiveness in ferret trachea. to remove the effects of sensory innervation, segments of ferret trachea were ma ... | 2003 | 12730146 |
| eye-specific retinogeniculate segregation independent of normal neuronal activity. | the segregation of initially intermingled left and right eye inputs to the dorsal lateral geniculate nucleus (dlgn) during development is thought to be in response to precise spatial and temporal patterns of spontaneous ganglion cell activity. to test this hypothesis, we disrupted the correlated activity of neighboring ganglion cells in the developing ferret retina through immunotoxin depletion of starburst amacrine cells. despite the absence of this type of correlated activity, left and right e ... | 2003 | 12738869 |
| locations of neurons with respiratory-related activity in the ferret brainstem. | previous transneuronal tracing studies conducted in the ferret revealed that a large population of neurons that provides inputs to diaphragm and abdominal motoneurons is located in the ventral magnocellular portion of the medial medullary reticular formation. these observations raise the possibility that the neural substrate underlying respiratory rhythmogenesis may be different in the ferret than in other species in which this circuitry has been explored. in the present study, systematic tracki ... | 2003 | 12742642 |
| brain penetration of aprepitant, a substance p receptor antagonist, in ferrets. | the pharmacokinetics, metabolism, and brain penetration of the neurokinin 1 (nk1) receptor antagonist (substance p receptor antagonist), aprepitant (mk-0869), were examined in ferrets. this species exhibits human-type nk1receptor pharmacology and is of proven value in the identification of clinically useful drugs for the treatment of chemotherapy-induced nausea and vomiting in humans. after a single p.o. dose of aprepitant at 1 or 2 mg/kg, plasma levels of the compound were between approximately ... | 2003 | 12756213 |
| effects of anaesthesia and manual restraint on the plasma concentrations of pituitary and adrenocortical hormones in ferrets. | two experiments were carried out to investigate the effect of sampling techniques on the plasma concentrations of pituitary and adrenocortical hormones in ferrets (mustela putorius furo). in the first experiment blood was collected on two occasions from 29 ferrets which were either manually restrained or anaesthetised with isoflurane. in the second experiment eight intact ferrets were fitted with jugular catheters and blood was collected on four occasions, just before and as soon as possible aft ... | 2003 | 12762488 |
| factors affecting the morphology of radial glia. | a model of cortical dysplasia results from disruption of the earliest generated neocortical cells. injections of an antimitotic (methylazoxy methanol - mam) into pregnant ferrets result in a constellation of effects, which include disruption of radial glia, with early differentiation in astrocytes, and impaired migration of neurons into the cortical plate. we found previously that culture of p0 mam-treated slices with explants of normal cortical plate reorganizes the radial glia toward their nor ... | 2003 | 12764030 |
| alopecia attributed to neoplastic ovarian tissue in two ferrets. | ferrets with adrenal gland dysfunction have alopecia as their most common clinical sign of disease. two cases of alopecia in neutered female ferrets are reported that were associated instead with neoplastic tissue found at the site of an ovarian pedicle. androstenedione and 17-hydroxyprogesterone, but not estradiol, concentrations were high in both ferrets. following surgical resection of the abnormal tissue in one ferret, the high hormone values decreased quickly and hair regrowth ensued. in bo ... | 2003 | 12784857 |
| delta9-tetrahydrocannabinol selectively acts on cb1 receptors in specific regions of dorsal vagal complex to inhibit emesis in ferrets. | the aim of this study was to investigate the efficacy, receptor specificity, and site of action of delta9-tetrahydrocannabinol (thc) as an antiemetic in the ferret. thc (0.05-1 mg/kg ip) dose-dependently inhibited the emetic actions of cisplatin. the ed50 for retching was approximately 0.1 mg/kg and for vomiting was 0.05 mg/kg. a specific cannabinoid (cb)1 receptor antagonist sr-141716a (5 mg/kg ip) reversed the effect of thc, whereas the cb2 receptor antagonist sr-144528 (5 mg/kg ip) was ineffe ... | 2003 | 12791597 |
| brain nitric oxide synthase expression in the developing ferret lateral geniculate nucleus: analysis of time course, localization, and synaptic contacts. | nitric oxide (no) is a diffusible neurotransmitter that has been implicated in key developmental events, including the refinement of retinogeniculate axons into on/off sublayers in the ferret lateral geniculate nucleus (lgn), and in the formation of eye-specific laminae in other species. to understand the role of no in the lgn, it is critical to fully characterize the pattern of brain nitric oxide synthase (bnos) expression within the nucleus, including the phenotype of the neural elements that ... | 2003 | 12794737 |
| neuropeptide expression following ligation of the ferret lingual nerve. | previous studies on the ferret inferior alveolar nerve found a close association between the spontaneous neural activity generated at a site of nerve injury, and the accumulation of neuropeptides in the injured axons. more recent electrophysiological studies on the lingual nerve revealed high levels of spontaneous activity 3 days after injury, a decline at 3 weeks and a late rise at 3 months. in the present study we have used immunocytochemical techniques to see whether this time course of spont ... | 2003 | 12798158 |
| the receptive-field organization of simple cells in primary visual cortex of ferrets under natural scene stimulation. | the responses of simple cells in primary visual cortex to sinusoidal gratings can primarily be predicted from their spatial receptive fields, as mapped using spots or bars. although this quasilinearity is well documented, it is not clear whether it holds for complex natural stimuli. we recorded from simple cells in the primary visual cortex of anesthetized ferrets while stimulating with flashed digitized photographs of natural scenes. we applied standard reverse-correlation methods to quantify t ... | 2003 | 12805314 |
| lycopene supplementation inhibits lung squamous metaplasia and induces apoptosis via up-regulating insulin-like growth factor-binding protein 3 in cigarette smoke-exposed ferrets. | higher intake of lycopene is related to a lower risk of lung cancer in human studies. lung cancer risk is associated with higher plasma levels of insulin-like growth factor i (igf-i) and/or lower levels of igf-binding protein 3 (igfbp-3). however, little is known regarding whether lycopene can inhibit cigarette smoke-induced lung carcinogenesis through modulation of igf-i/igfbp-3, cell proliferation, and apoptosis. we investigated the effects of lycopene supplementation at a low dose (1.1 mg/kg/ ... | 2003 | 12810641 |
| two epochs in the development of gamma-aminobutyric acidergic neurons in the ferret thalamus. | these studies chart the development of gamma-aminobutyric acid (gaba)-ergic neurons in the three divisions of the thalamus (ventral thalamus, dorsal thalamus, and epithalamus). gabaergic neurons were identified by in situ hybridization to localize mrna for 67-kda glutamic acid decarboxylase (gad(67)) and related to the morphological maturation of the thalamus in fetal and postnatal brains and to expression of transcription factors gbx-2 and tbr-1. origins of gabaergic neurons were sought in in v ... | 2003 | 12811802 |
| reelin-immunoreactive neurons, axons, and neuropil in the adult ferret brain: evidence for axonal secretion of reelin in long axonal pathways. | reelin is a large secretable protein which, when developmentally defective, causes the reeler brain malformation in mice and a recessive form of lissencephaly with cerebellar hypoplasia in humans. in addition, reelin is heavily expressed throughout the adult brain, although its function/s there are still poorly understood. to gain insight into which adult neuronal circuits may be under the influence of reelin, we systematically mapped reelin-immunoreactive neuronal somata, axons, and neuropil in ... | 2003 | 12811805 |
| immunohistochemical analysis of two strains of lion (panthera leo)-adapted canine distemper virus in ferrets (mustela putorius furo). | canine distemper virus (cdv) caused epizootics in lions (panthera leo) in tanzania's serengeti national park in 1994 and in captive lions and other panthera spp. in the usa in 1991-1992. in this study, immunohistochemistry was used to compare viral distribution in tissues collected from ferrets (mustela putorius furo) inoculated with one of the two lion-derived cdv isolates, either from serengeti (a94-11/13) or from california (a92-27/20). the california isolate resulted in severe morbidity in a ... | 2003 | 12824519 |
| glucose-6-phosphate isomerase is necessary for embryo implantation in the domestic ferret. | the mechanism of implantation in carnivores is poorly understood. however, a previously unidentified 60-kda protein has been shown to be necessary for embryo implantation in ferrets. here we identify this protein as glucose-6-phosphate isomerase (gpi). gpi is expressed by the corpus luteum on days 6-9 of pregnancy, the time at which implantation-promoting activity has been found in corpora lutea. passive immunization against gpi reduced the number of implantation sites in pregnant ferrets in a d ... | 2003 | 12826606 |
| mapping multiple features in the population response of visual cortex. | stimulus features such as edge orientation, motion direction and spatial frequency are thought to be encoded in the primary visual cortex by overlapping feature maps arranged so that the location of neurons activated by a particular combination of stimulus features can be predicted from the intersections of these maps. this view is based on the use of grating stimuli, which limit the range of stimulus combinations that can be examined. we used optical imaging of intrinsic signals in ferrets to a ... | 2003 | 12827202 |
| fungal diseases of ferrets. | although fungal disease in ferrets is uncommon, a few cases have been documented, demonstrating that it should be on the clinician's rule out list, especially if the patient has a long-term illness that is not responding appropriately to antibiotics, as was the clinical presentation in many of these documented cases. | 2003 | 12827732 |
| factors associated with aggression between pairs of domestic ferrets. | to identify factors (eg, familiarity, sex, neutering status, and time of year) associated with aggression between domestic ferrets and test a method for reducing aggression when introducing ferrets. | 2003 | 12830862 |
| transneuronal tracing of neural pathways influencing both diaphragm and genioglossal muscle activity in the ferret. | in prior experiments that employed the transneuronal transport of isogenic recombinants of pseudorabies virus (prv), we demonstrated that neurons located ventrally in the medial medullary reticular formation (mrf) of the ferret provide collateralized projections to both diaphragm and abdominal muscle motoneurons as well as to multiple abdominal muscle motoneuron pools. the goal of the present study was to determine whether single mrf neurons also furnish inputs to diaphragm motoneurons and those ... | 2003 | 12832431 |
| decline of the critical period of visual plasticity is concurrent with the reduction of nr2b subunit of the synaptic nmda receptor in layer 4. | the specific composition of nmda receptor subunits is thought to underlie the developmental plasticity of the cortex revealed by unbalanced binocular stimulation. however, evidence that nr2 subunits change in correlation with the critical period at locations that are relevant to visual plasticity has been missing. using preembedding and postembedding immunostaining, as well as electron microscopy, we quantified the volumetric densities of nr1-, nr2a-, and nr2b-containing synapses in layers 4 and ... | 2003 | 12832545 |
| immature cortex lesions alter retinotopic maps and interhemispheric connections. | unilateral lesions of the occipital visual areas performed on postnatal day 5 (p5) in the ferret are not compensated by the appearance, in the lesioned hemisphere, of visual responses at ectopic locations. instead, when parts of the visual areas are spared, they show abnormal retinotopic organizations; furthermore, callosal connections are abnormally distributed in relation to the retinotopic maps. lesions that completely eliminate the visual areas including the posterior parietal cortex cause t ... | 2003 | 12838520 |
| role of calcineurin in activity-dependent pattern formation in the dorsal lateral geniculate nucleus of the ferret. | in the retinogeniculate pathway of the ferret, in addition to the separation of the inputs from the two eyes to form eye-specific layers, there is also an anatomical segregation of the terminal arbors of on-center retinal ganglion cells from the terminal arbors of off-center retinal ganglion cell axons to form on/off sublaminae. sublamination normally occurs during postnatal weeks 3-4 and requires the activity of retinal afferents, n-methyl-d-aspartate receptors, nitric oxide synthase, and a tar ... | 2003 | 12838580 |
| transfer of antibody via mother's milk. | differing from humans, igg from breast milk in many animal species (rodents, bovines, cats, ferrets, etc.) are transported across the intestinal epithelium into the neonatal circulation. this transport is located at the duodenal and jejunal level where enterocytes express a surface membrane receptor able to bind fc of igg and to facilitate transcytosis of these immunoglobulins. fcgamma-r, which is very similar to the placenta receptor responsible for active transplacental transfer of igg in huma ... | 2003 | 12850343 |
| hyperosmolar solutions stimulate mucus secretion in the ferret trachea. | study objectives: inhalation of hypertonic saline or mannitol solutions acutely increases mucociliary clearance. because increased clearance is often coupled with increased mucus secretion, we hypothesized that hyperosmolar agents would stimulate mucus secretion. setting and subjects: the isolated tracheae of healthy young adult ferrets were studied in a basic research laboratory. measurements and results: we demonstrated that there was a dose-dependent increase in mucin secretion by enzyme-link ... | 2003 | 12853538 |
| functional connectivity between the superficial and deeper layers of the superior colliculus: an anatomical substrate for sensorimotor integration. | the superior colliculus (sc) transforms both visual and nonvisual sensory signals into motor commands that control orienting behavior. although the afferent and efferent connections of this midbrain nucleus have been well characterized, little is know about the intrinsic circuitry involved in sensorimotor integration. transmission of visual signals from the superficial (ssc) to the deeper layers (dsc) of the sc has been implicated in both the triggering of orienting movements and the activity-de ... | 2003 | 12878701 |
| cannabinoid1 receptor in the dorsal vagal complex modulates lower oesophageal sphincter relaxation in ferrets. | delta9-tetrahydrocannabinol (delta9-thc) is an effective anti-emetic; however, other potential gastrointestinal therapeutic effects of delta9-thc are less well-known. here, we report a role of delta9-thc in a vago-vagal reflex that can result in gastro-oesophageal reflux, that is, gastric distension-evoked lower oesophageal sphincter (los) relaxation. oesophageal, los and gastric pressures were measured using a miniaturized, manometric assembly in decerebrate, unanaesthetized ferrets.gastric dis ... | 2003 | 12879865 |
| ethanol influences on native t-type calcium current in thalamic sleep circuitry. | ethanol is known to disrupt normal sleep rhythms; however, the cellular basis for this influence is unknown. this study uses an in vitro slice preparation coupled with electrophysiological recordings to probe neuronal responses to acute ethanol exposure. recordings were conducted in ferret and rat thalamic slices, since thalamic circuitry is an integral component of sleep/wake cycles and sleep spindles. a key mediator of spindle wave activity is the low-threshold calcium current (t-type current) ... | 2003 | 12893844 |
| sequence analysis of the fragment of the phosphoprotein gene of polish distemper virus isolates. | the nucleotide sequence analysis of the 429 bp fragment of the p gene of 11 polish field isolates of canine distemper virus (cdv), reference strains and other virus isolates available in the genbank was the aim of the studies. high homology between all dog strains from east-southern region of poland and reference strains of cdv was demonstrated. it was estimated as 97-100 % for cdv-ond; 96.7-99.8 % for cdv-rock; 96.7-99.8 % for cdv-led and 96.3-97.9 % for a75-17. the 100 % homology of the nucleo ... | 2003 | 12898335 |
| synthesis and structure-activity relationships of 2-substituted-8-hydroxyadenine derivatives as orally available interferon inducers without emetic side effects. | recently we reported the adenine derivatives (2-4) as new interferon (ifn) inducers. in the present study, we conducted a detailed structure and activity relationship study of 4 and its related derivatives on ifn inducing activity. from this study, we found that compound 4 exhibited the most potent ifn inducing activity in vitro with a minimum effective concentration of 0.01 microm, and 4 also showed strong ifn-inducing activity at doses of more than 0.3mg/kg by oral administration in mice. this ... | 2003 | 12901909 |
| acoustic factors govern developmental sharpening of spatial tuning in the auditory cortex. | auditory localization relies on the detection and interpretation of acoustic cues that change in value as the head and external ears grow. here we show that the maturation of these structures is an important determinant for the development of spatial selectivity in the ferret auditory cortex. spatial response fields (srfs) of high-frequency cortical neurons recorded at postnatal days (p) 33-39 were broader, and transmitted less information about stimulus direction, than in older ferrets. they al ... | 2003 | 12910241 |
| activational and organizational effects of estradiol on male behavioral neuroendocrine function. | evidence is reviewed that establishes an essential role for estradiol, synthesized locally via aromatization of testosterone in the adult as well as the developing male nervous system of rats, ferrets, and mice, in both the organization and adult activation of neural circuits that control appetitive as well as consummatory components of masculine sexual behavior. evidence is also reviewed suggesting that perinatal estradiol biosynthesis and action in the female's nervous system may contribute to ... | 2003 | 12914584 |
| spontaneous activity of morphologically identified ganglion cells in the developing ferret retina. | whole-cell patch-clamp recordings were made from morphologically identified ganglion cells in the intact retina of developing ferrets. as early as 3 d after birth, all ganglion cells exhibited bursts of spontaneous activity, with the interval between bursts gradually decreasing with maturity. by 2 weeks after birth, ganglion cells could be morphologically differentiated into three major classes (alpha, beta, and gamma), and at this time each cell class was characterized by a distinct pattern of ... | 2003 | 12917368 |
| in vivo efficacy in airway disease models of n-(3,5-dichloropyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic acid amide (awd 12-281), a selective phosphodiesterase 4 inhibitor for inhaled administration. | n-(3,5-dichloro-pyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic acid amide (awd 12-281) is a highly potent and selective phosphodiesterase 4 (pde4) inhibitor that was designed to have a metabolic profile that was optimized for topical administration. the aim of the current study was to explore the pharmacological profile of intratracheally administered awd 12-281 in different models of asthma and chronic obstructive pulmonary disease (copd) in comparison with steroids. to assess ... | 2003 | 12944497 |
| neural model for physiological responses to frequency and amplitude transitions uncovers topographical order in the auditory cortex. | we characterize primary auditory cortex (ai) units using a neural model for the detection of frequency and amplitude transitions. the model is a generalization of a model for the detection of amplitude transition. a set of neurons, tuned in the spectrotemporal domain, is created by means of neural delays and frequency filtering. the sensitivity of the model to frequency and amplitude transitions is achieved by applying a 2-dimensional rotatable receptive field to the set of spectrotemporally tun ... | 2003 | 12944531 |
| antigenic and genomic relation between human influenza viruses that circulated in argentina in the period 1995-1999 and the corresponding vaccine components. | the analysis of epidemic influenza virus has been focused on antigenic and genomic characterization of the hemagglutinin (ha) glycoprotein in order to detect new variants for the recommendation of the vaccine strains in each season. since october 1998, who organized a second meeting to evaluate the vaccine formula for the southern hemisphere. | 2003 | 12957183 |
| incidence of adverse events in ferrets vaccinated with distemper or rabies vaccine: 143 cases (1995-2001). | to determine the incidence of adverse events in ferrets vaccinated with a modified-live avian cell culture canine distemper virus vaccine licensed for use in ferrets, an inactivated rabies vaccine licensed for use in ferrets, or both. | 2003 | 12959385 |
| caveolin-1 regulates contractility in differentiated vascular smooth muscle. | caveolin is a principal component of caveolar membranes. in the present study, we utilized a decoy peptide approach to define the degree of involvement of caveolin in pkc-dependent regulation of contractility of differentiated vascular smooth muscle. the primary isoform of caveolin in ferret aorta vascular smooth muscle is caveolin-1. chemical loading of contractile vascular smooth muscle tissue with a synthetic caveolin-1 scaffolding domain peptide inhibited pkc-dependent increases in contracti ... | 2004 | 12969891 |
| experimental production of gingival hyperplasia in ferrets given epanutin (sodium diphenyl hydantoinate). | 1952 | 12987574 | |
| active immunization of ferrets by simultaneous injections of avianized canine distemper vaccine and anticanine distemper hyperimmune serum. | 1953 | 13010091 | |
| [sensitivity of the ferret to the virus of canine infectious hepatitis]. | 1952 | 13020106 | |
| on the life history of ascaris devosi and its development in the white mouse and the domestic ferret. | 1953 | 13026280 | |
| observations on tuberculosis in the ferret, mustela furo l. | 1953 | 13061624 | |
| multiple carcinomata and focal mast-cell accumulations in the skin of a ferret (mustela furo l.) with a note on other tumours in ferrets. | 1953 | 13062048 | |
| rubarth's disease (canine virus hepatitis) ii. the insusceptibility of ferrets to experimental infection. | 1953 | 13109039 | |
| distemper immunization of ferrets by nebulization with egg adapted virus. | 1954 | 13122043 | |
| experimental infection of dogs, ferrets, chinchillas and hamsters with vesicular stomatitis virus. | 1954 | 13124685 | |
| effects of sex hormones and gender on attraction thresholds for volatile anal scent gland odors in ferrets. | body odors contribute to mate recognition and sexual partner preference in many mammals, including ferrets. we used a habituation/dishabituation procedure to test whether sex steroid hormones influence whether ferrets will approach and investigate different concentrations of volatile anal scent gland odors from male and female conspecifics. when tested with high concentrations of anal scent gland secretions in oil vehicle, gonadectomized male and female ferrets that received no sex steroids reli ... | 2003 | 13129482 |
| the onset of oestrus in normal and blinded ferrets. | 1954 | 13145635 | |
| rapid protection of ferrets against fully virulent distemper virus with nebulized attenuated distemper virus. | 1954 | 13150760 | |
| [infectious leukopenia of cats. presence in the infected organism of corpuscles analogous to chlamydozoaceae. receptivity of ferret and white mouse]. | 1954 | 13173022 | |
| effect of pituitary stalk section light-induced oestrus in the ferret. | 1954 | 13194018 | |
| actinomycosis and torulosis in the ferret (mustela furo l). | 1954 | 13211859 | |
| the effect of pituitary-stalk section on light-induced oestrus in ferrets. | 1954 | 13215503 |