Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| sequence, structure, and dynamic determinants of hsp27 (hspb1) equilibrium dissociation are encoded by the n-terminal domain. | human small heat shock protein 27 (hsp27) undergoes concentration-dependent equilibrium dissociation from an ensemble of large oligomers to a dimer. this phenomenon plays a critical role in hsp27 chaperone activity in vitro enabling high affinity binding to destabilized proteins. in vivo dissociation, which is regulated by phosphorylation, controls hsp27 role in signaling pathways. in this study, we explore the sequence determinants of hsp27 dissociation and define the structural basis underlyin ... | 2012 | 22264079 |
| reliability and validity of the multidimensional dyspnea profile (mdp). | abstract background:most measures of dyspnea assess a single aspect (intensity or distress) of the symptom. we developed the multidimensional dyspnea profile (mdp) to measure qualities and intensities of the sensory dimension and components of the affective dimension. the mdp is not indexed to a particular activity and can be applied at rest, during exertion, or clinical care. we report on the development and testing of the mdp in patients with a variety of acute and chronic cardiopulmonary cond ... | 2012 | 22267681 |
| efficacy and safety of concurrent chemoradiation with weekly cisplatin ± low-dose celecoxib in locally advanced undifferentiated nasopharyngeal carcinoma: a phase ii-iii clinical trial. | background: this is the first study that aimed to determine the efficacy and safety of concurrent chemoradiation with weekly cisplatin ± celecoxib 100 mg twice daily in locally advanced undifferentiated nasopharyngeal carcinoma. materials and methods: eligible patients had newly diagnosed locally advanced (t3-t4, and/or n2-n3, m0) undifferentiated nasopharyngeal carcinoma, no prior therapy, karnofsky performance status ≥ 70, and normal organ function. the patients were assigned to receive 7 wee ... | 2011 | 22269407 |
| spontaneus bilateral pedicle fracture 30 years after harrington instrumentation for idiopathic scoliosis: a case report. | abstract: introduction: spontaneous fractures of the spine are a common entity. they usually occur in older people with osteoporosis. this case is presented on account of its rarity. to the best of the authors' knowledge only one case of an osteoporotic pedicle fracture after harrington instrumentation has been described before. case presentation: we report the case of a 46-year-old caucasian woman who underwent surgery due to idiopathic scoliosis with a harrington instrumentation (t4 to l3) 3 ... | 2012 | 22269652 |
| comparison of clinical outcomes for patients with large choroidal melanoma after primary treatment with enucleation or proton beam radiotherapy. | purpose: to evaluate survival and clinical outcome for patients with a large uveal melanoma treated by either enucleation or proton beam radiotherapy (pbrt). procedures: this retrospective non-randomized study evaluated 132 consecutive patients with t3 and t4 choroidal melanoma classified according to tnm stage grouping. results: cumulative all-cause mortality, melanoma-related mortality and metastasis-free survival were not statistically different between the two groups (log-rank test, p = 0.56 ... | 2012 | 22269846 |
| double-probe signal enhancing strategy for toxin aptasensing based on rolling circle amplification. | on the basis of aptamer-based rolling circle amplification (rca) and magnetic beads (mbs), a highly sensitive electrochemical method was developed for the determination of ochratoxin a (ota). initially, an amino-modified capture dna was immobilized onto mbs for the following hybridization with an ota aptamer and a phosphate labeled padlock dna. in the presence of ota, the aptamer would dissociate from the bioconjugate, and the padlock dna would subsequently hybridize with the capture dna to form ... | 2011 | 22270050 |
| the determining risk factors for treatment outcomes in patients with squamous cell carcinoma of the hard palate. | background: the determining risk factors for patients with squamous cell carcinoma of the hard palate are not well verified. methods: medical records from our facility of all patients with squamous cell carcinoma of the hard palate receiving curative surgery between march 2003 and may 2009 were reviewed. results: seventy-eight patients were enrolled in ... | 2012 | 22271207 |
| clinical and histologic features of inverted papilloma-associated malignancy. | the objectives of the study were to analyze the clinical features of inverted papillomas (ip) associated with malignancy and to evaluate the correlation of tumor stage, survival and histolologic features. we conducted a retrospective review of 18 ip associated with malignancy patients. in addition, we compared histopathologic characteristics (tumor differentiation and malignant cell proportion) with clinical outcomes. eleven of the tumors were present on the nasal cavity and 7 on the maxillary s ... | 2012 | 22271282 |
| a longitudinal assessment of early pubertal timing as a predictor of psychosocial changes in adolescent girls with and without spina bifida. | objective: a longitudinal comparison of adolescent girls with and without spina bifida (sb), regarding the effects of early pubertal timing on girls' depressive symptoms, mother-daughter conflict, and emotional distancing. methods: 62 mother-daughter dyads (31 with sb and 31 without) reported on psychosocial outcomes at 5 time points (ages 8/9 to 16/17 years). results: a pubertal timing × sb status interaction predicted emotional distancing (t2), conflict (t2, t5), and depressive symptoms (t4) ... | 2012 | 22271794 |
| severe rhabdomyolysis and acute renal failure in an adolescent with hypothyroidism. | hypothyroidism has been reported rarely as the cause of rhabdomyolysis in adults and children. we present here a non-compliant adolescent with a diagnosis of hypothyroidism who developed rhabdomyolysis and acute renal failure with no additional predisposing factor. a 13-year-old girl with a previous history of hypothyroidism due to thyroid hypoplasia presented with generalized myalgia, malaise, vomiting, and oliguria lasting for three days. neurological examination revealed bilateral marked weak ... | 2011 | 22272466 |
| omega-3 polyunsaturated fatty acids enrichment alters performance and immune response in infectious bursal disease challenged broilers. | abstract: background: infectious bursal disease (ibd) results in economic loss due to mortality, reduction in production efficiency and increasing the usage of antibiotics. this study was carried out to investigate the modulatory roles of dietary n-3 polyunsaturated fatty acids (pufa) enrichment in immune response and performance of ibd challenged broiler chickens. methods: a total of 300 day old male broiler chicks were assigned to four dietary n-3 pufa ascending levels as the treatment group ... | 2012 | 22273277 |
| the role of chemoradiotherapy in patients with unresectable t4 breast tumors. | purpose: unresectable t4 tumors of the breast are usually treated with systemic therapies, while the role of local therapies remains debatable. this study aims to evaluate the effectiveness of chemoradiotherapy as a part of t4 breast cancer treatment, and to assess the role of local radiotherapies in patients with unresectable t4 breast tumors. materials/methods: between february 1998 and june 2010, 39 unresectab ... | 2012 | 22274798 |
| [capacities of diagnostic volumetric multislice spiral computed tomography in the diagnosis of gastric cancer]. | in the period 2009 to 2010, diagnostic multislice spiral computed tomography (msct) was carried out in 49 patients with gastric cancer. the efficiency of dynamic msct in detecting a tumor and determining its locoregional extent was evaluated. the results of dynamic msct were compared with those of postoperative histological examination. the possibility of detecting gastric cancer by dynamic msct was ascertained to depend on the depth of tumor invasion and to average 29, 71, 72, and 77% for t1, t ... | 2011 | 22288146 |
| [comparison of the maternal and neonatal effects of combined spinal-epidural block and spinal block for cesarean section]. | combined spinal-epidural block (cseb) has gained increasing interest as it combines the reliability of a spinal block (sb) and the flexibility of an epidural block in cesarean section. we investigated the maternal and fetal effect of cseb against sb in cesarean operation. | 2011 | 22290681 |
| clinical and pathological response rates of docetaxel-based neoadjuvant chemotherapy in locally advanced breast cancer and comparison with anthracycline-based chemotherapies: eight-year experience from single centre. | the administration of neoadjuvant chemotherapy (nact) prior to local therapy is advantageous for women with locally advanced breast cancer (labc), since it can render inoperable tumors resectable and can increase rates of breast conservative surgeries. | 2011 | 22293253 |
| the content of cadmium, cobalt and nickel in laryngeal carcinoma. | the aim of the study was to determine the content of cadmium (cd), cobalt (co) and nickel (ni) in the samples from laryngeal carcinoma in comparison with the level of these elements in the samples of healthy mucous membrane from the same larynx. | 2011 | 22295038 |
| [clinical observation of injection of dexmedetomidine in anaesthesia for esophageal cancer operation]. | to investigate the effects of administration of dexmedetomidine in anaesthesia for esophageal cancer operation. | 2011 | 22295535 |
| nestin expression associates with poor prognosis and triple negative phenotype in locally advanced (t4) breast cancer. | nestin, an intermediate filament protein, has traditionally been noted for its importance as a neural stem cell marker. however, in recent years, expression of nestin has shown to be associated with general proliferation of progenitor cell populations within neoplasms. there is no reported study addressing nestin expression in t4 breast cancer patients. thus, the aim of the present study was to investigate, through immunohistochemistry, the expression and distribution of nestin in t4 breast canc ... | 2011 | 22297445 |
| effect of anesthesia on the changes in the hormones levels during and after transvesical prostatectomy. | hypovolemia and pain are direct stimulators of hormonal response to trauma. thus, neuroendocrine, metabolic and inflammatory aspects of the injury are part of an overall "stress response". in particular, it manifests in patients undergoing surgical intervention. these reactions can occur with trauma, burns, severe infections and physical exertion. metabolic and neuroendocrine response to surgical intervention depends on several factors, such as severity and duration of the surgical trauma, patie ... | 2011 | 22299297 |
| patterns of differentiated thyroid cancer in baluchistan province of pakistan: some initial observations. | the incidence of thyroid cancer is increasing in several countries. the main objective of this retrospective study was to find and describe province-specific estimates of incidence in males and females by age groups for differentiated thyroid cancer (dtc). this study reports on 87 cases of dtc from baluchistan province of pakistan treated with post operative radioiodine at the center for nuclear medicine and radiotherapy (cenar) quetta from january 2003 to december 2009. the patient data has bee ... | 2011 | 22299551 |
| [effect of shenfu injection on the erythrocyte immune function of patients undergoing cardiopulmonary bypass]. | to observe the effect of shenfu injection (sfi) on erythrocyte immunity function of patients undergoing cardiopulmonary bypass (cpb). | 2011 | 22303706 |
| [establishment of gynecological asthenia cold syndrome model]. | to establish the model of gynecological asthenia cold syndrome by simulating the etiology of gynecological asthenia cold syndrome depending on 'pathogenic cold impairing yang" in chinese medicine theory. | 2011 | 22303717 |
| normal thyroid function in young adults who were born very preterm. | there is some evidence for elevated thyrotropin (tsh) levels in children born preterm, but follow-up studies into adulthood are lacking. we tested whether thyroid function in young adults born at a gestational age < 32 weeks, with either an appropriate (appropriate for gestational age, aga) or low birth weight for gestational age (small for gestational age, sga), differed from that in age-matched controls. we made our measurements when the study participants reached 21 years of age. serum concen ... | 2011 | 22308837 |
| neurodevelopment of preterm infants born at 28 to 36 weeks of gestational age: the role of hypothyroxinemia and long-term outcome at 4 years. | hypothyroxinemia in premature neonates may affect long-term neurodevelopment. | 2011 | 22308839 |
| central hypothyroidism following chemotherapy for acute lymphoblastic leukemia. | it has been suggested that chemotherapy per se might impair the hypothalamus-pituitary-thyroid axis of childhood cancer survivors. | 2011 | 22308840 |
| concomitant radiotherapy and chemotherapy for high-risk nonmelanoma skin carcinomas of the head and neck. | background. to report on the use and feasibility of a multimodality approach using concomitant radiotherapy and chemotherapy in patients with high-risk nonmelanoma skin carcinoma (nmsc) of the head and neck. methods. records of patients with nmsc of the head and neck who received concomitant crt at the university of north carolina between 2001 and 2007 were reviewed. results. fifteen identified patients had at least one of the following high-risk factors: t4 disease (93%), unresectability (60%), ... | 2011 | 22312508 |
| spontaneous vacuolar degeneration of the thyroid follicular epithelium in cynomolgus monkeys. | vacuolar degeneration of the thyroid follicular epithelium was observed in two untreated female cynomolgus monkeys assigned to control groups. in light microscopy, large vacuoles containing a homogenous substance occupied the basal region of the epithelium, and the nuclei had shifted toward the apical region. the vacuoles showed negative reactions to pas and thyroglobulin. electron microscopic observation revealed dilatation of the rough endoplasmic reticulum corresponding to the vacuoles. the p ... | 2011 | 22319235 |
| [clinical observation of visual quality after implantation of toric intraocular lens]. | to observe the visual quality after implantation of acrysof toric intraocular lens (iol) in cataract patients. | 2011 | 22321501 |
| clinicopathologic significance of gastric adenocarcinoma with neuroendocrine features. | composite neuroendocrine-exocrine carcinomas are malignancies that have two distinct components residing within the same tumor: an adenocarcinomatous portion and a neuroendocrine portion. this is rare in gastric cancers; however, poorly differentiated adenocarcinomas can sometimes reveal evidence of neuroendocrine features (nef) or be 'mixed endocrine and exocrine carcinomas'. this study aimed to review nef in gastric adenocarcinoma and to evaluate its prognostic significance. | 2011 | 22324009 |
| breast cancer in women under 40 years of age. | it is widely believed that breast cancer in young women is characterized by a relatively unfavorable prognosis and unusual pathological features. the aim of this study was to investigate clinicopathological and biological characteristics in young patients with breast cancer. | 2011 | 22331714 |
| [the clinical application of monitored anesthesia care in percutaneous dilatational tracheostomy]. | to investigate the changes in hemodynamics and depth of anesthesia under monitored anesthesia care (mac) in patients undergoing percutaneous dilatational tracheostomy (pdt). | 2011 | 22332577 |
| [endoscopic surgery and endoscopy-assisted surgery for the malignant transformation of sinonasal inverted papilloma]. | to investigate malignant transformation of sinonasal inverted papilloma (sip) treated by nasal endoscopic and endoscopy-assisted surgery. | 2011 | 22336018 |
| [identification of nucleolar localization signal sequence of tumor metastasis suppressor gene-1]. | to identify the putative specific localization signal sequence of tumor metastasis suppressor gene-1 (tmsg-1) and to explore the mechanism of subcellular localization of tmsg-1 protein. | 2011 | 22336162 |
| comparison of compensatory sweating and quality of life following thoracic sympathetic block for palmar hyperhidrosis: electrocautery hook versus titanium clip. | video-assisted thoracic sympathetic block is an effective, safe, and minimally invasive method for treatment of primary hyperhidrosis. the purpose of this study was to decide which one of using electrocautery hook and titanium clip is the appropriate procedure for primary palmar hyperhidrosis by assessing the compensatory sweating (cs) and quality of life (qol) of patients after sympathetic block. | 2011 | 22340165 |
| effects of preoperative ketamine on the endocrine-metabolic and inflammatory response to laparoscopic surgery. | ketamine is hypothesized to reduce perioperative endocrine-metabolic and inflammatory responses in cardiac surgery patients. this randomized, placebo-controlled, double-blind study was performed to determine whether perioperative endocrine-metabolic and inflammatory responses are attenuated by preoperative administration of ketamine to healthy females receiving elective laparoscopic surgery. | 2011 | 22340231 |
| effects of extrusion and heat treatment on the mechanical properties and biocorrosion behaviors of a mg-nd-zn-zr alloy. | mechanical properties at room temperature and biocorrosion behaviors in simulated body fluid (sbf) at 37 °c of a new type of patented mg-3nd-0.2zn-0.4zr (hereafter, denoted as jdbm) alloy prepared at different extrusion temperatures, as well as heat treatment, were studied. the mechanical properties of this magnesium alloy at room temperature were improved significantly after extrusion and heat treatment compared to an as-cast alloy. the results of mechanical properties show that the yield stren ... | 2011 | 22340687 |
| reversal of difluoromethylornithine effects by the administration of putrescine in rats. | to assess the reversal of di-fluoromethyl ornithine (dfmo) effects by administration of putrescine on thyroid glands in rats. | 2011 | 22355995 |
| on-pump coronary artery bypass graft surgery: biochemical, hormonal and cellular features. | the authors sought to assess biochemical, hormonal and cellular repercussions from use of cardiopulmonary bypass (cpb) in coronary artery bypass graft (cabg) surgery. | 2011 | 22358266 |
| [ileus caused by metastasis of cutaneous malignant melanoma: case report]. | in this case report we describe rare metastatic appearance of cutaneous malignant melanoma ( mm) in small intestine followed by clinical appearance of acute surgical abdomen. a 42-year old women operated in our hospital in april 2009. due to unusual naevus on her right arm. pathologicaly it was mm grossly 1.5 cm, microscopically breslow 11 mm, clark's level iv (t4), number of mitosis 1.4 per mm2, without ulcerations. she was sent to continue treatment at the national referal center for melanoma ... | 2011 | 22359897 |
| prevalence of subclinical hypothyroidism among patients with acute myocardial infarction. | introduction. subclinical hypothyroidism (sch) is defined as a serum thyroid-stimulating hormone (tsh) level above the upper limit of normal despite normal levels of serum free thyroxine. there is growing evidence that sch is associated with increased cardiovascular risk. we tried to investigate prevalence of sch in acute myocardial infarction patients. methods and results. we evaluate free t3, free t4, and tsh levels of 604 patients (age 58.4) retrospectively, who have been admitted to the coro ... | 2011 | 22363888 |
| management of severe class ii division 1 malocclusion: a case report. | to describe the two-phase treatment of a preadolescent boy with a severe skeletal class ii division 1 malocclusion with vertical maxillary excess and spaced upper incisors. | 2011 | 22372276 |
| effect of ramadan fasting on body composition and physical performance in female athletes. | the aim of this study was to determine the effect of ramadan fasting on body composition, calorie intake and physical performance in young female athletes undertaking training sessions during ramadan. | 2011 | 22375235 |
| [resistance to thyroid hormone and hashimoto's thyroiditis]. | resistance to thyroid hormone (rth) is a rare condition characterized by elevation of thyroid stimulating hormone (tsh) and thyroid hormones (th). its association with hashimoto's thyroiditis was described in 1993 and occurs in 1 of 1.3 million births. | 2011 | 22385766 |
| an atypical case of retropharyngeal abscess with long blind tract treated with ryle's tube drainage. | a 10 year-old iban girl presented with severe odynophagia for 4 days and subcutaneous emphysema. clinically, her neck was tender with crepitus. lateral neck radiograph showed multiple linear radiolucent shadows at retropharyngeal space. flexible nasopharyngolaryngoscope revealed a tunnel behind upper oesophagus with slough and there was pooling of saliva at pyriform sinus. feeding via nasogastric tube was started and empirical treatment for fungal and bacterial infection was commenced. subsequen ... | 2011 | 22390112 |
| extradural en-plaque spinal meningioma with intraneural invasion. | extradural spinal meningiomas are rare. our understanding of purely extradural spinal meningiomas is incomplete because most reports rarely differentiate purely extradural meningiomas from extradural meningiomas with an intradural component. occasionally, reports have described involvement of the adjacent nerve root, but there has never been a description of an extradural meningioma that actually infiltrates the nerve root. | 2011 | 22405399 |
| [subclinical hypothyroidism and cardiovascular risk factors]. | to determine the prevalence of subclinical hypothyroidism in the general population of an urban health center and describe the clinical characteristics and cardiovascular risk factors in patients with subclinical hypothyroidism. | 2011 | 22411383 |
| study of the effects of hydrogen cyanide exposure in cassava workers. | hydrogen cyanide is the chemical responsible for tissue hypoxia. chronic exposure to hcn may cause neurological, respiratory, cardiovascular and thyroid defects. onset of symptoms depends on dose and duration of exposure. large scale of cassava processing could be disastrous due to discharge of hydrocyanic acid into the air. cassava processing is the major industrial work in and around salem. hence the present study is taken to assess the effects of hcn exposure in cassava workers. | 2011 | 22412292 |
| combined transoral and suprahyoid approach for oropharyngeal cancers: an alternative to mandibulotomy. | surgical treatment of oropharyngeal tumours usually requires mandibular osteotomy. using this technique allows a better exposure and an easier excision, but this approach often generates complications. since 1995, we used a less aggressive surgical technique, with a suprahyoid pharyngotomy when the oral approach was not sufficient, thus sparing the mandible. | 2011 | 22416489 |
| shelf life study of fresh celery (apium graveolens l.) grown under different nitrogen fertilization treatments. | nitrogen fertilization is useful for obtaining higher growth and quality of productions, and the use of nitrogen fertilization is widespread. to evaluate the influence of nitrogen-rich fertilizers on quality characteristics of celery, shelf life tests of celery grown with 2 levels of nitrogen and 2 different nitrogen fertilizers were performed. the treatments of the celery samples were identified as follows: t1, mineral nitrogen (80 kg ha(-1)); t2, mineral nitrogen (120 kg ha(-1)); t3, organic n ... | 2011 | 22417367 |
| the effects of short-term manipulation of thyroid hormone status coinciding with primary wool follicle development on fleece characteristics in merino sheep. | thyroidectomy surgery performed late in gestation results in perturbations in wool follicle development in foetal sheep, showing the importance of thyroid hormones for wool follicle development. the aim of this study was to determine the influence of transient manipulation of thyroid hormone status at a time corresponding with foetal primary wool follicle initiation. pregnant merino ewes (n = 12 per treatment) were treated daily between gestational days 55 and 64 with control (vehicle), exogenou ... | 2011 | 22440286 |
| single-molecule studies of viral dna packaging. | assembly of many dsdna viruses involves packaging of dna molecules into pre-assembled procapsids by portal molecular motor complexes. techniques have recently been developed using optical tweezers to directly measure the packaging of single dna molecules into single procapsids in real time and the forces generated by the molecular motor. three different viruses, phages phi29, lambda, and t4, have been studied, revealing interesting similarities and differences in packaging dynamics. single-molec ... | 2011 | 22440623 |
| concomitant chemoradiotherapy as a standard treatment for squamous cell carcinoma of the temporal bone. | we sought to characterize the effectiveness of concomitant chemoradiotherapy (ccrt) for patients with squamous cell carcinoma of the temporal bone. we performed a retrospective chart review of 14 patients with cancer of the temporal bone who were provided initial treatment in our hospital from december 2001 to november 2008. four patients with stage i tumors were treated by radiation therapy alone or with oral administration of s1. one patient with a stage ii tumor was treated by radiation thera ... | 2011 | 22451818 |
| craniofacial resection for sinonasal malignant tumors: statistical analysis of surgical outcome over 17 years at a single institution. | we present a retrospective analysis of surgical outcome of sinonasal malignant tumors. overall survival (os), disease-specific survival (dss), local control (lc), and disease-free survival (dfs) were calculated in 32 patients. prognostic factors for survival and functional outcomes were investigated. the median follow-up period was 70 months. at 5 years, os, dss, lc, and dfs rates were 0.722, 0.745, 0.851, and 0.707, respectively. prognostic factors for poor os were involvement of the frontal si ... | 2011 | 22470267 |
| aggressive hemangioma of the thoracic spine. | vertebral hemangiomas are common lesions and usually considered benign. a rare subset of them, however, are characterized by extra-osseous extension, bone expansion, disturbance of blood flow, and occasionally compression fractures and thereby referred to as aggressive hemangiomas. we present a case of a 67-year-old woman with progressive paraplegia and an infiltrative mass of t4 vertebra causing mass effect on the spinal cord. multiple conventional imaging modalities were utilized to suggest th ... | 2011 | 22470764 |
| suppression of seizure by cathodal transcranial direct current stimulation in an epileptic patient - a case report -. | epilepsy is an intractable disease, though many treatment modalities have been developed. recently, noninvasive transcranial direct current stimulation (tdcs), which can change brain excitability, was introduced and has been applied for therapeutic purposes regarding epilepsy. a suppression of seizures was experienced by cathodal tdcs in a medication refractory pediatric epileptic patient. the patient was an 11-year-old female who had focal cortical dysplasia of the cerebral hemisphere. the pati ... | 2011 | 22506177 |
| [functional assessment of the different types of anterior cruciate ligament plasty used at the xoco general hospital arthroscopy service]. | currently, anterior cruciate ligament lesions have an increased frequency; their management is predominantly surgical; there are several functional assessment systems. | 2011 | 22512111 |
| successful treatment of t4 renal cell carcinoma after a neoadjuvant targeted therapy using sunitinib: report of a case. | since the introduction of targeted therapy, treatment of metastatic renal cell carcinoma (rcc) has undergone dramatic changes. responses to targeted therapy within the primary tumor and metastatic lesions are novel findings not seen with immunotherapeutic-based strategies. we report here a case of t4 rcc in which cytoreductive nephrectomy became possible after a neoadjuvant targeted therapy using sunitinib. our experience with the present case suggests that targeted therapy in the neoadjuvant se ... | 2011 | 22531125 |
| immediate intraocular pressure rise after intravitreal injection of ranibizumab and two doses of triamcinolone acetonide. | to evaluate prospectively immediate intraocular pressure (iop) changes after the intravitreal injection of ranibizumab, 2 and 4mg triamcinolone acetonide. | 2011 | 22553690 |
| how common is hypothyroidism after external radiotherapy to neck in head and neck cancer patients? | to identify the occurrence of clinical and subclinical hypothyroidism among head and neck cancer patients receiving radiation to the neck and to justify routine performing of thyroid function tests during follow-up. | 2011 | 22557780 |
| failure patterns in patients with esophageal cancer treated with definitive chemoradiation. | local failure after definitive chemoradiation therapy for unresectable esophageal cancer remains problematic. little is known about the failure pattern based on modern-day radiation treatment volumes. we hypothesized that most local failures would be within the gross tumor volume (gtv), where the bulk of the tumor burden resides. | 2011 | 22565611 |
| primary sjögren's syndrome or multiple sclerosis? our experience concerning the dilemma of clinically isolated syndrome. | the authors present the case of a 50 years old woman who during 3 years had a transient right limbs palsy, and numerous episodes of unilateral/bilateral optic neuropathy. the csf and mri examinations did not sustain the diagnosis of multiple sclerosis (ms). after 2 years from the onset, she presented bilateral trigeminal neuropathy, and after 9 months the anti-ss-a and anti ss-b antibodies were positive. the sialography and the minor salivary ducts biopsy (in the absence of xerostomia and xeroph ... | 2011 | 22568276 |
| "transferred to another institution": clinical histories of psychiatric patients murdered in the nazi "euthanasia" killing program. | this study aims to examine the practice of medical reporting in a totalitarian environment including systematic killing of people with mental illness in nazi germany. the historical analysis is based on patient documents and administrative files at today's district hospital, gunzburg, as well as on patient documents of inventory r 179 of the branch office of the federal archives (bundesarchiv) in berlin/lichterfelde. the paper describes four patient histories and attempts to reconstruct some asp ... | 2011 | 22572090 |
| incidence of incidental carcinoma gall bladder in cases of routine cholecystectomy. | carcinoma of gall bladder is the most common malignancy of the billiary tract. most of the cases are diagnosed as an incidental case among patients undergoing cholecystectomy. | 2011 | 22610859 |
| triiodothyronin, thyroxine and thyrotropin in vitiligo. | vitiligo is a common pigmentary disorder of the skin, affecting individuals globally. not only is this ailment psychologically incapacitating, it also has a high incidence of autoimmunity, signifying that its manifestations may be the portrayal of dysfunction of immune system. | 2011 | 22610860 |
| correlation of metabolism/hypoxia markers and fluorodeoxyglucose uptake in oral squamous cell carcinomas. | the objective of this study was to analyze the relationship between the uptake of (18)f-2-fluoro-2-deoxy-d-glucose (fdg) by positron emission tomography-computerized tomography (pet-ct) and glucose metabolism/hypoxia markers in oral squamous cell carcinoma (oscc). | 2011 | 22676927 |
| paraneoplastic subacute sensory neuronopathy in association with adenocarcinoma of the prostate. | paraneoplastic syndromes arise infrequently in prostate cancer and paraneoplastic subacute sensory neuronopathy has not previously been reported in association with prostate cancer. when paraneoplastic syndromes occur, it is usually in the setting of small-cell carcinoma of the prostate or advanced, hormone-resistant disease. here the authors report a 64- year-old man who developed a progressive, severe, sensory neuronopathy in the setting of a recently diagnosed stage t4 hormone-responsive pros ... | 2011 | 22689835 |
| spontaneous spinal epidural haematoma due to arteriovenous malformation in a child. | spontaneous spinal epidural haematoma (sseh) is a rare clinical entity, especially in infants, in whom only a few cases have been reported. in a paediatric emergency setting, sseh should be considered as part of the differential diagnosis for acute extremity weakness and paraesthesia. epidural vascular malformations are often suspected in these cases but have rarely been demonstrated. the authors report herein a case of sseh in a 9-year-old boy arising from an epidural vascular malformation. he ... | 2011 | 22696725 |
| a phase ii study of docetaxel, cisplatin and 5- fluorouracil (tpf) in patients with locally advanced head and neck carcinomas. | the combination of cisplatin and 5-fluorouracil (pf) is currently considered a standard and effective regimen for the treatment of advanced head and neck carcinomas. the aim of this study was to evaluate the efficacy and safety of docetaxel, cisplatin and 5-fluorouracil (tpf) in patients with unresectable head and neck carcinomas. | 2011 | 22737461 |
| copy number changes of crisp3 in oral squamous cell carcinoma. | the aim of this study was to identify tumor suppressor genes (tsgs) in oral squamous cell carcinoma (oscc) using whole-genome analysis of microarray technology and real-time quantitative polymerase chain reaction (qpcr). we applied whole-genome analysis of tsgs in the specimens from 3 patients of oscc by microarray technology. a total of 11 genes, crisp3, scgb3a1, agr2, pip, c20orf114, tff1, stath, azgp1, muc7, dmbt1 and loc389429, were found to be down-regulated, and 2, matrix metallopeptidase ... | 2011 | 22740859 |
| successful bortezomib treatment in combination with dexamethasone and thalidomide for previously untreated epidural plasmacytoma. | epidural plasmacytoma is a rare clinical entity of plasma cell neoplasms. the optimal management of extra medullary plasmacytoma remains unclear, particularly for bulky masses. in this study, we report the case of a 35-year-old male who presented with the inability to walk, urinary incontinence and superficial and deep sensory disturbance. spinal magnetic resonance imaging revealed a large epidural mass compressing the spinal cord at the level of t2-t4. the patient underwent surgical t2-t4 verte ... | 2011 | 22740951 |
| surgical treatment of papillary thyroid carcinoma. | papillary carcinoma accounts for 85% of differentiated thyroid cancers. we witness a yearly increased incidence and this is may be, in part, due to the increasing use of neck ultrasonography. certain histologic subtypes of papillary carcinoma have a worse prognosis related to vascular invasion, invasion into extrathyroidal tissues, extensive tumor necrosis and/or mitoses. adequate surgery is the most important treatment variable influencing prognosis, while radioactive iodine treatment, tsh supp ... | 2011 | 22746009 |
| chemoradiation in advanced head and neck cancers: a comparison of two radiosensitizers, paclitaxel and cisplatin. | to compare the locoregional control rates, survival outcome and toxicity profiles between two groups of patients of squamous cell carcinoma (scc) of head and neck (stage iii & iv) receiving concomitant chemo-radiotherapy with paclitaxel and cisplatin. a prospective study was done on 94 previously untreated patients of histopathologically proved squamous cell carcinoma of head and neck region-ajcc stage iii & iv (t3 & t4 with n0 -n3, m0) treated with concomitant chemoradiation. the patients were ... | 2011 | 22754800 |
| subclinical hypothyroidism in childhood obesity and its correlation with lipoproteins. | there is an ongoing debate regarding the influence of subclinical hypothyroidism on body mass index. the objectives of the study were (i) to determine whether levels of thyroid stimulating hormone (tsh) are elevated in obese children, (ii) to compare the serum levels of triiodothyronine (t3) and thyroxine (t4) in obese with non-obese and (iii) to examine the association of subclinical hypothyroidism with lipoproteins and body mass index. | 2011 | 22783686 |
| [the state of thyroid system in patients with non-traumatic supratentorial hematomas]. | concentrations of thyroid hormones (thyrotrophic - ttg, t3, t4) were measured with radioimmunological assay in the blood serum of 69 operated patients with supratentorial stroke interbrain hematomas. hematomas were removed using a puncture/ aspiration method with local fibrinolysis. the lethality was 19%. it has been shown that medial hematomas lead to the decrease in ttg secretion while lateral and lobar ones inhibit t4 and t3 synthesis. replacement therapy with thyroid hormones is needed to im ... | 2011 | 22792746 |
| diagnostic accuracy of fine needle aspiration cytology in thyroid swellings. | proper management of the disease depends upon accurate diagnosis. fine needle aspiration cytology has become the investigation of choice because of its high accuracy, simplicity, minimal-invasiveness, quick result and reliability. | 2011 | 22929705 |
| a case of resistance to thyroid hormone with chronic thyroiditis: discovery of a novel mutation (i54v). | resistance to thyroid hormone (rth) is a rare disorder characterized by variable tissue hyporesponsiveness to thyroid hormone, usually caused by mutations in the thyroid hormone receptor beta (trβ). it has been reported that the serum of patients with rth is free of auto-antibodies against thyroglobulin (tg) and thyroid peroxidase (tpo), except in rare cases where coincidental autoimmune thyroiditis is also present. we describe a 13-year-old girl with chronic thyroiditis and rth. this patient ha ... | 2011 | 22937287 |
| expression of p-akt and p-mtor in a large series of bronchopulmonary neuroendocrine tumors. | bronchopulmonary neuroendocrine tumors (bp-nets) are separated into four subgroups: typical carcinoid tumor (tc), atypical carcinoid tumor (ac), large-cell neuroendocrine carcinoma (lcnec) and small-cell lung carcinoma (sclc). the signaling pathway involving akt/mammalian target of rapamycin (mtor) is crucial to the regulation of cell growth, proliferation and survival, and is frequently activated in human cancers. consequently, mtor is considered an attractive target for anticancer agents. the ... | 2011 | 22977576 |
| the first phage electron micrographs. | the first phage electron micrographs were published in 1940 in germany and proved the particulate nature of bacteriophages. phages and infected bacteria were first examined raw and unstained. us american scientists introduced shadowing and freeze-drying. phages appeared to be tailed and morphologically heterogeneous. phage types identified by early electron microscopy include enterobacteriophages t4, t1, t7, t5, 7-11, vii and pseudomonas phage pb1. this paper retraces the development of early vi ... | 2011 | 23050215 |
| [viability and efects of the probiotic lactobacillus aracaseissp aracasei in chilean low-fat gauda cheese]. | the objective of this study is to infer the survival of the probiotic lactobacillus paracasei ssp paracasei added during the processing of low-fat gouda cheese, during the maturation (21 days) and the commercialization (14 days), in order to see the influence that this organism has on the quality of the product. the treatments were: ti (control): gouda with normal fat content; t2: low fat gouda cheese (qgs) t3: qgs, with additional probiotic added with the initial culture; t4: qgs, with the prob ... | 2011 | 23094525 |
| the incidence of interval cancers in the german mammography screening program: results from the population-based cancer registry in north rhine-westphalia. | cancer screening programs must meet high standards for quality and effectiveness, because many healthy persons need to be screened to detect relatively few cases of cancer. in this study, we use the rate of interval cancers as an important surrogate indicator for evaluating the german mammography screening program (msp). | 2012 | 23264826 |
| the prognostic significance of hypoxia inducing factor 1-α in oropharyngeal cancer in relation to human papillomavirus status. | this study examines the prognostic significance of hypoxia inducing factor-1α (hif-1α) expression in relation to human papillomavirus (hpv) status in oropharyngeal squamous cell carcinoma (scc). | 2012 | 23266008 |
| surgical treatment of ossification of the ligamentum flavum associated with dural ossification in the thoracic spine. | between january 2006 and december 2009, dural ossification (do) was found intraoperatively in 26 of 98 patients with thoracic spinal stenosis due to ossification of the ligamentum flavum (olf). mri showed single-level (n = 2), two-level (n = 8) and multilevel (n = 16) areas of low signal intensity in the ligamentum flavum of the thoracic spine. of the 68 ossified segments in the study population, 11 (16.2%) were located in the upper thoracic spine (t1-t4), nine (13.2%) were located in the midtho ... | 2012 | 23266313 |
| effect of corticosterone on growth and welfare of broiler chickens showing long or short tonic immobility. | tonic immobility (ti) test is commonly used to assess fear. animals showing different ti durations demonstrate distinct behavior and biochemical responses to stress. however, less is known about how ti phenotype affects growth and welfare of domestic fowl. in this study, broiler chickens (gallus gallus) were classified into short and long ti duration (sti and lti) phenotypes and treated chronically with vehicle (con) or corticosterone (cort). sti broilers demonstrated significantly higher growth ... | 2012 | 23266338 |
| [a case of advanced hepatocellular carcinoma with tumor thrombosis in the main trunk of the portal vein successfully treated by multidisciplinary therapies]. | we report a case of advanced hepatocellular carcinoma(hcc) with tumor thrombosis in the main trunk of the portal vein successfully treated by multidisciplinary therapies. this case is that of a 61-year-old man with loss of appetite and weight loss. the abdominal computed tomography revealed an early enhanced and late wash-out lesion in the right hepatic lobe and tumor thrombosis in the major trunk of the portal vein. we diagnosed advanced hcc related to chronic hepatitis c [t4 (vp4) n0m0, stage ... | 2012 | 23267913 |
| [complete response obtained by preoperative chemotherapy in a case of t4 rectal cancer]. | a 48-year-old man, who had presented with anal pain and cloudy urine, was referred to our hospital. colonoscopy showed a type 2 circular tumor at the higher rectum, and a diagnosis of well-differentiated adenocarcinoma was made by biopsy. ct demonstrated increased thickness of the rectum wall, an equivocal boundary between the rectum and the bladder, and abnormal gas production in the bladder. following diagnosis of t4 rectal cancer, preoperative chemotherapy was initiated with the aim of downst ... | 2012 | 23267941 |
| [evaluation of chemoradiotherapy for stage ii and iii( non-t4) esophageal cancer]. | we retrospectively evaluated the clinical efficacy of chemoradiotherapy for surgically resectable stage ii and iii (non-t4) esophageal cancer. | 2012 | 23267987 |
| a survey of host range genes in poxvirus genomes. | poxviruses are widespread pathogens, which display extremely different host ranges. whereas some poxviruses, including variola virus, display narrow host ranges, others such as cowpox viruses naturally infect a wide range of mammals. the molecular basis for differences in host range are poorly understood but apparently depend on the successful manipulation of the host antiviral response. some poxvirus genes have been shown to confer host tropism in experimental settings and are thus called host ... | 2012 | 23268114 |
| [clinical analysis of patients with stage iv ( colorectal cancer after palliative resection of primary tumor]. | to investigate the independent predictors of postoperative mortality, morbidity, and long-term survival in patients with stage iv ( colorectal cancer. | 2012 | 23268278 |
| eplt4 proteinaceous elicitor produced in pichia pastoris has a protective effect against cercosporidium sofinum infections of soybean leaves. | a complementary dna library was constructed from the mycelium of trichoderma asperellum t4, and a highly expressed gene fragment named eplt4 was found. in order to find a more efficient and cost-effective way of obtaining eplt4, this study attempted to produce eplt4 using a pichia pastoris expression system. the gene encoding eplt4, with an additional 6-his tag at the c-terminus, was cloned into the yeast vector ppic9k and expressed in the p. pastoris strain gs115 to obtaining more protein for t ... | 2012 | 23271623 |
| thyroid hormones and erythrocyte indices in a cohort of euthyroid older subjects. | hypothyroidism is associated with normocytic anaemia. indeed, a limited number of studies have shown significant associations between free thyroxin (t4) and erythrocyte indices. these studies did not include vitamin b12, folic acid, iron and renal function in the analyses. we therefore studied the association between thyroid hormones and erythrocyte indices in a population-based cohort of older euthyroid subjects, with adjustment for major confounding parameters. | 2012 | 23276452 |
| cryoelectron microscopy analysis of small heat shock protein 16.5 (hsp16.5) complexes with t4 lysozyme reveals the structural basis of multimode binding. | small heat shock proteins (shsps) are ubiquitous chaperones that bind and sequester non-native proteins preventing their aggregation. despite extensive studies of shsps chaperone activity, the location of the bound substrate within the shsp oligomer has not been determined. in this paper, we used cryoelectron microscopy (cryoem) to visualize destabilized mutants of t4 lysozyme (t4l) bound to engineered variants of the small heat shock protein hsp16.5. in contrast to wild type hsp16.5, binding of ... | 2012 | 23277356 |
| comparison between cranial thoracic intervertebral disc herniations in german shepherd dogs and other large breed dogs. | cranial thoracic intervertebral disc herniations have been reported to be rare in dogs due to the presence of the intercapital ligament, however some studies have proposed they may not be uncommon in german shepherd dogs. the purpose of this retrospective study was to compare cranial thoracic intervertebral disc herniations in german shepherd dogs and other large breed dogs (control group). medical records at the ontario veterinary college were searched for german shepherd dogs and other large b ... | 2012 | 23278950 |
| endoscopic ultrasound in restaging and predicting pathological response for advanced gastric cancer patients after neoadjuvant chemotherapy. | aim: to evaluate the role of endoscopic ultrasound (eus) in restaging and predicting response after neoadjuvant chemotherapy in patients with advanced gastric cancer. methods: in all, 48 advanced gastric cancer patients were recruited from june 2007 to december 2010 after providing their written, informed consent. all patients underwent an eus before and after three cycles of neoadjuvant chemotherapy (folfox 6), and then a radical resection was performed 3-4 weeks after chemotherapy. the results ... | 2012 | 23279745 |
| [radio and chemotherapy in gallbladder cancer: a latin american consensus]. | no randomized controlled trials have been conducted in gallbladder cancer to establish standard treatments. we therefore conducted the first latin american consensus meeting for the management of gallbladder cancer. in this paper we report the conclusions of the experts' panel for (neo) adjuvant treatment of resectable gallbladder cancer. these are based on the review of the literature, the discussion of the participating experts and the vote of the assistants (surgical oncologists, medical onco ... | 2012 | 23282782 |
| [the influence of subclinical thyroid dysfunction on cardiac hemodynamic and electrophysiological parameters in patients with coronary heart disease and paroxysmal atrial fibrillation]. | the study included 58 patients with chd and paroxysmal atrial fibrillation divided into 2 groups depending on thyroid hormone and thyrotropin levels. group 1 was comprised of 24 patients with subclinical hypothyroidism, group 2 of 18 ones with subclinical hyperthyroidism. control group consisted of l6 patients with chd, paroxysmal atrial fibrillation and normal thvroid function. it was shown that patients with chd, paroxysmal atrial fibrillation and subclinical thyrotoxicosis had t3 and t4 level ... | 2012 | 23285759 |
| [immunological characteristics in subjects with heart connective tissue dysplasia depending on thyroid hormone levels and vegetative dysfunction]. | patients with heart connective tissue dysplasia (hctd) are known to be subject to infectious and inflammatory diseases due to peculiarities of their immune system. we studied 181 patients with hctd depending on thyroid hormone levels and vegetative dysfunction. hctd was shown to be associated with a significant decrease of igm levels and increase of circulating immune complexes. the igg level in patients with mitral valve prolapse (mvp), anomalous chord localization, and combination of mpv and t ... | 2012 | 23285764 |
| association between osteopontin and egfr expression with clinicopathological parameters in hepatocellular carcinoma. | osteopontin (opn) and epidermal growth factor receptor (egfr) are important factors associated with tumor progression, invasion and metastasis in humans. the aim of this study was to assess the correlation of opn and egfr expression with hepatocellular carcinoma (hcc) progression. expression of opn and egfr was assessed by immunohistochemistry in 100 hcc specimens. immunostaining scores (0 to 400) were calculated from the percentage of cells (0 to 100) at each immunostaining intensity and the im ... | 2012 | 23286449 |
| [subcarinal lymph node metastasis and strategy of lymphadenectomy in thoracic esophageal carcinoma]. | to assess the metastatic frequency of subcarinal lymph nodes of thoracic esophageal carcinoma and its influencing factors, in order to determine the adequate range of lymph node dissection during esophagectomy. | 2012 | 23291134 |
| detection of t4 polynucleotide kinase activity with immobilization of tio2 nanotubes and amplification of au nanoparticles. | determination of nucleotide kinase activity is valuable due to its importance in regulating nucleic acid metabolism. herein, we describe a strategy for simply and accurately determining nucleotide kinase activity by tio2 nanotubes mediated signal transition and au nanoparticles amplification. in this method, dna containing 5'-hydroxyl group is self-assembled onto a gold electrode and used as a substrate for t4 polynucleotide kinase (pnk). by the specific immobilization affinity of tio2 nanotubes ... | 2012 | 23291616 |
| distribution of contrast medium epidurally injected at thoracic and lumbar vertebral segments. | the epidural distribution of iohexol (0.2 ml/kg) administered at thoracic vertebrae (thoracic group) and lumbar vertebrae (lumbar group) was compared by computed tomographic (ct) epidurography in dogs. the total spread of iohexol was similar between the 2 groups upon reaching a similar cranial level. the maximal ct values were higher at the c7/t1 and t4/t5 levels in thoracic group, but they were higher at the t13/l1 and l4/l5 levels in lumbar group (p<0.05). this result suggests that the distrib ... | 2012 | 23292108 |