Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| speed and efficiency in walking and wheeling with novel stimulation and bracing systems after spinal cord injury: a case study. | to compare various novel and conventional systems for locomotion, a 25-year-old man was studied with motor complete spinal cord injury at the t4/5 level. he used various devices in the community, and changes in speed, physiological cost index (pci), and oxygen consumption were measured periodically. speed was fastest with a conventional manual wheelchair (nearly 120 m/min in a 4-min test). speed was about 30% less, but the pci was lowest (highest efficiency) using functional electrical stimulati ... | 2005 | 22151555 |
| the force-velocity relationship of paralyzed quadriceps muscles during functional electrical stimulation cycling. | objectives. to investigate the nature of the force-velocity relationship on muscle forces and power outputs during functional electrical stimulation (fes)-evoked cycling at different pedaling cadences. materials and methods. ten patients with t4-t9 spinal cord injuries (asia a) performed fes-evoked cycling at 50 rev/min using a motorized isokinetic ergometer for 20 min, after which quadriceps crank torque and power were measured at 10, 30, and 50 rev/min. results. pedal cadence affected both ... | 2007 | 22151814 |
| dynamics of friendship networks and alcohol use in early and mid-adolescence. | similarity in alcohol consumption among adolescent friends could be caused by the influence of friends or by the selection of friends who consume similar levels of alcohol. this article aims to disentangle influence and selection processes while specifically examining changes over time in these processes and possible differences between reciprocal and nonreciprocal friendships. | 2012 | 22152667 |
| how type of parturition and health status influence hormonal and metabolic profiles in newborn foals. | thyroid hormones, insulin growth factor i (igf-i) and non-esterified fatty acids (nefa) represent important hormonal and metabolic factors associated with perinatal growth and maturation. their action could be influenced by the type of parturition and the health status of the foal and therefore the aim of this work is to evaluate their plasma concentrations in newborn foals during the first 2 wks of life. three groups of subjects were enrolled: 15 healthy foals born by spontaneous parturition, 2 ... | 2011 | 22153270 |
| structural conservation of the myoviridae phage tail sheath protein fold. | bacteriophage phikz is a giant phage that infects pseudomonas aeruginosa, a human pathogen. the phikz virion consists of a 1450 å diameter icosahedral head and a 2000 å-long contractile tail. the structure of the whole virus was previously reported, showing that its tail organization in the extended state is similar to the well-studied myovirus bacteriophage t4 tail. the crystal structure of a tail sheath protein fragment of phikz was determined to 2.4 å resolution. furthermore, crystal structur ... | 2011 | 22153511 |
| Preoperative Radiation Therapy for Upper Rectal CancerT3,T4/Nx: Selectivity Essential. | This review explores the current available literature regarding the role of neoadjuvant therapy for upper locally advanced rectal cancers (=10cm-15cm). Although there is a paucity of data evaluating the outcomes of preoperative chemoradiation for upper rectal cancers the authors suggest that T3N0 tumors will not likely benefit from radiation and that treatment of T4N0 should be individualized. | 2011 | 22154165 |
| Restriction enzyme-free construction of random gene mutagenesis libraries in Escherichia coli. | Directed evolution relies on both random and site-directed mutagenesis of individual genes and regulatory elements to create variants with altered activity profiles for engineering applications. Central to these experiments is the construction of large libraries of related variants. However, a number of technical hurdles continue to limit routine construction of random mutagenesis libraries in Escherichia coli, in particular, inefficiencies during digestion and ligation steps. Here, we report a ... | 2011 | 22155067 |
| presence of free cancer cells in the peritoneal cavity of patients who underwent curative gastrectomy with lymph node dissection. | background/aims: the aim of this study was to determine the ratio of patients with positive peritoneal cytology who underwent radical gastrectomy for gastric cancer, to evaluate the factors effecting risk of positive cytology and to analyze the effects cytology findings on survival. methodology: peritoneal lavage samples were obtained from 255 patients who underwent radical gastrectomy with d2 (184 patients) or d3 (71 patients) lymph node dissection between january 2000 and december 2007. result ... | 2011 | 22155861 |
| resolution of spam following cordectomy: implications for understanding pathophysiology. | study design:case report.objective:to describe the clinical benefit of a spinal cordectomy with the aim of limiting neurological deterioration related to the development of a subacute posttraumatic ascending myelopathy (spam) supporting previously described mechanism for spam formation.setting:national spinal injuries centre, stoke mandeville hospital, uk.method and results:a 38-year old patient presented 6 months after spinal cord injury substantial neurological deterioration expanding from the ... | 2011 | 22158252 |
| multiple synchronous primary tumours in a single lobe. | we present the case of a 70-year-old man with three synchronous histologically different primary tumours in the same lobe. he initially presented with an intermittent productive cough, dyspnoea and non-specific abdominal pains. radiological investigation revealed three areas of high-intensity fludeoxyglucose uptake of varying size within the right upper lobe. he underwent thoracoscopic right upper lobectomy. histological analysis confirmed the three lesions to be undifferentiated squamous cell c ... | 2011 | 22159234 |
| Caveolin-1 as a potential high-risk prostate cancer biomarker. | Current diagnostic techniques of prostate cancer cannot efficiently distinguish the latent and low-risk forms from the high-risk significant forms of prostate cancer. Caveolin-1 (Cav-1), except other functions, plays an important role in cell transformation and the process of tumorigenesis. Furthermore, Cav-1 is involved in metastatic processes. It has also been shown that Cav-1 expression is induced under stress conditions, such as oxi ... | 2011 | 22159333 |
| investigation of bacteriophage t4 by atomic force microscopy. | bacteriophage t4 was visualized using atomic force microscopy (afm). the images were consistent with, and complementary to electron microscopy images. head heights of dried particles containing dna were about 75 nm in length and 60 nm in width, or about 100 nm and 85 nm respectively when scanned in fluid. the diameter of hydrated tail assemblies was 28 nm and their lengths about 130 nm. seven to eight pronounced, right-handed helical turns with a pitch of 15 nm were evident on the tail assemblie ... | 2011 | 22164350 |
| a single-step competitive binding assay for mapping of single dna molecules. | optical mapping of genomic dna is of relevance for a plethora of applications such as scaffolding for sequencing and detection of structural variations as well as identification of pathogens like bacteria and viruses. for future clinical applications it is desirable to have a fast and robust mapping method based on as few steps as possible. we here demonstrate a single-step method to obtain a dna barcode that is directly visualized using nanofluidic devices and fluorescence microscopy. using a m ... | 2011 | 22166208 |
| phase ii trial of preoperative chemotherapy with docetaxel, cisplatin and s-1 for t4 locally advanced gastric cancer. | the standard treatment for t4 locally advanced gastric cancer is gastrectomy with d2 lymph node dissection followed by adjuvant chemotherapy with s-1 for 12 months; however, prognostic outcome in stage iiib has been insufficient. it is expected that survival is improved by preoperative treatment with a triplet regimen of docetaxel, cisplatin and s-1 (divided dcs therapy). a multicenter phase ii study has been conducted to evaluate the safety and efficacy of two courses of preoperative chemothera ... | 2011 | 22167664 |
| [association between a meningioma and an occult thyroid carcinoma in congenital hypothyroidism.] | the presence of a thyroid carcinoma and a defect in thyroid hormone synthesis in a 27 year ols female is reported. when she was 13 years old a clinical diagnosis of hypothyroid cretinism was made, based on a defect of iodide organification which was demostrated by thiocyanate test showing a discharge of 55 % of 131i at 45 minutes. she intermittently received thyroid hormone until she died. few days before dying she had normal values of t3, t4 and tsh. her parents are related and she had a 35 yea ... | 1980 | 22167704 |
| critical behavior of megabase-size dna toward the transition into a compact state. | we studied the changes in the higher-order structure of a megabase-size dna (s120-1 dna) under different spermidine (spd) concentrations through single-molecule observations using fluorescence microscopy (fm) and atomic force microscopy (afm). we examined the difference between the folding transitions in s120-1 dna and sub-megabase-size dna, t4 dna (166 kbp). from fm observations, it is found that s120-1 dna exhibits intra-chain segregation as the intermediate state of transition, in contrast to ... | 2011 | 22168726 |
| enantioselective cleavage of supercoiled plasmid dna catalyzed by chiral macrocyclic lanthanide(iii) complexes. | the enantiomers of the sm (iii), eu (iii) and yb (iii) complexes [lnl(no(3))(2)](no(3)) of a chiral hexaazamacrocycle were tested as catalysts for the hydrolytic cleavage of supercoiled plasmid dna. the catalytic activity was remarkably enantioselective; while the [lnl(ssss)(no(3))(2)](no(3)) enantiomers promoted the cleavage of plasmid pbr322 from the supercoiled form (sc) to the nicked form (nc), the [lnl(rrrr)(no(3))(2)](no(3)) enantiomers were inactive. kinetics of plasmid dna hydrolysis was ... | 2011 | 22169034 |
| the surgical management and prognosis of renal cell cancer with ivc tumor thrombus: 15-years of experience using a multi-specialty approach at a single uk referral center. | objectives: surgical management of renal cell carcinoma (rcc) invading the inferior vena cava (ivc) remains a technical challenge. however, radical surgery is the only potentially curative treatment. we set out to review our experience of using a multi-specialty approach to these patients over the last 15 years. patients and methods: fifty patients with rcc and ivc invasion underwent surgery at our institution (mean age: 59 years). tumor thrombus was infrahepatic/levels i and ii: n = 24, intrahe ... | 2011 | 22169073 |
| agreement between semi-automatic radiographic morphometry and genant semi-quantitative method in the assessment of vertebral fractures. | semi-automatic morphometry is highly reproducible and not time intensive; however, no study has evaluated agreement between semi-automated morphometric methods and the genant semi-quantitative method performed as a rule by radiologists. our study shows substantial agreement between both methods; however, semi-automatic morphometry upgrades mild deformities and overestimates the prevalence of fractures. introduction: the aim of this st ... | 2011 | 22170523 |
| locally advanced nasopharyngeal carcinoma: current and emerging treatment strategies. | although nasopharyngeal carcinoma (npc) is a widespread malignant tumor, it is particularly frequent in southeast asia. although t1 tumors can be effectively controlled with exclusive radiotherapy, this treatment modality is insufficient for most npc patients, who present with locally advanced disease at diagnosis. in fact, for stages ranging from t2b n0 to t4 n3, definitive scientific evidence supports the use of concurrent platinum-based chemotherapy with standard external beam radiotherapy. t ... | 2011 | 22171280 |
| The Evolution of Thyroid Function with Puberty. | Objective: This study was planned to describe thyroid functional status in different stages of puberty. Study design: We collected data from 5 schools across different geographical zones of Delhi. All children who consented were evaluated for anthropometry, pubertal stage, goitre status, serum free T3 (FT3), free T4 (FT4), TSH, anti-TPO (thyroid peroxidase) antibodies and thyroid ultrasound. From this sample, a disease- and risk-free or "reference population" was obtained by excluding those wi ... | 2011 | 22171622 |
| [locally advanced rectal cancer managment: which role for the pathologist in 2011?]. | locally advanced rectal cancers mainly correspond to lieberkünhien adenocarcinomas and are defined by t3-t4 lesions with or without regional metastatic lymph nodes. such tumors benefit from neoadjuvant treatment combining chemotherapy and radiotherapy, followed by surgery with total mesorectum excision. such a strategy can decrease the rate of local relapse and lead to an easier complementary surgery. the pathologist plays an important role in the management of locally advanced rectal cancer. in ... | 2011 | 22172116 |
| Viral Infections in Septic Shock (VISS-Trial)-Crosslinks Between Inflammation and Immunosuppression. | BACKGROUND: Recent investigations provided evidence that herpes simplex virus (HSV-1) and cytomegalovirus (CMV) are reactivated in critically ill individuals. However, at this time, it remains unclear whether these viral infections are of real pathogenetic relevance or represent innocent bystanders. MATERIALS AND METHODS: In total, 60 patients with septic shock were enrolled. Blood samples and tracheal secretion were collected at the time of sepsis diagnosis (T0) as well as 7 d (T1), 14 d (T2), ... | 2011 | 22172138 |
| membrane and nuclear permeabilization by polymeric pdna vehicles: efficient method for gene delivery or mechanism of cytotoxicity? | the aim of this study is to compare the cytotoxicity mechanisms of linear pei to two analogous polymers synthesized by our group: a hydroxyl-containing poly(l-tartaramidoamine) (t4) and a version containing an alkyl chain spacer poly(adipamidopentaethylenetetramine) (a4) by studying the cellular responses to polymer transfection. we have also synthesized analogues of t4 with different molecular weights (degrees of polymerization of 6, 12, and 43) to examine the role of molecular weight on the c ... | 2011 | 22175236 |
| Is the Kidney a Major Storage Site for Thyroxine as Thyroxine Glucuronide? | Background: Previous studies have shown that thyroxine (T4) is stored as T4 glucuronide (T4G) in the kidney, and that 24 hours after administration of [(125)I]T4 to mice, 17% of the radioactivity was present in the kidneys, whereas only 4% was found in the liver. The present study was carried out to determine the relative amounts of conjugated and unconjugated T4 and 3,5,3'-triiodothyronine (T3) in the kidney and liver, and whether the conjugated hormones are extracted from tissues using our est ... | 2011 | 22175240 |
| Neoadjuvant Chemotherapy in 29 Patients with Locally Advanced Follicular or Hürthle Cell Thyroid Carcinoma: A Phase 2 Study. | Background: It is believed that chemotherapy (ChT) is ineffective in follicular thyroid carcinoma (FTC) and Hürthle cell thyroid carcinoma (HCTC). The aim of our retrospective study was to find out whether neodjuvant ChT before thyroid surgery had any effect on the size of primary tumor in patients with FTC or HCTC. Methods: The study included 29 patients (20 women, 9 men; mean age: 60.8 years) with FTC or HCTC who had T3 or T4 tumor and were treated with neoadjuvant ChT from 1979 to 2004. A m ... | 2011 | 22175241 |
| Value of Repeat Stimulated Thyroglobulin Testing in Patients with Differentiated Thyroid Carcinoma Considered to Be Free of Disease in the First Year After Ablation. | Background: In patients with differentiated thyroid carcinoma considered to be free of the disease after initial therapy, the appropriate timing or necessity of subsequent stimulated thyroglobulin (Tg) testing is uncertain. The objective of this study was to determine the value of a repeat stimulated Tg in patients considered to be free of disease 6-12 months after thyroid ablation, and also who continued to have serum Tg <1?ng/mL while on thyrotropin suppressive doses of thyroxine (T4) (Tg/T4), ... | 2011 | 22175271 |
| minimally invasive lateral approach for symptomatic thoracic disc herniation: initial multicenter clinical experience. | object symptomatic herniated thoracic discs remain a surgical challenge and historically have been associated with significant complications. while neurological outcomes have improved with the abandonment of decompressive laminectomy, the attempt to minimize surgical complications and associated morbidities continues through less invasive approaches. many of these techniques, such as thoracoscopy, have not been widely adopted due to technical difficulties. the current study was performed to ex ... | 2011 | 22176427 |
| Reproductive biomarkers to identify endocrine disruption in Clarias gariepinus exposed to 4-nonylphenol. | The present study investigated the hormones concentrations and gonads alterations of Clarias gariepinus caused by sublethel concentrations of 4-nonylphenol (0, 0.05, 0.08 and 0.1mg/l). The changes in the activities of the hormones after exposure to these sublethel doses of 4-nonylpenol referred to endocrine disruption in Clarias gariepinus in association with histopathological changes in reproductive tissues. The levels of thyroid stimulating hormone (TSH), triiodothyronine (T3), total thyroxine ... | 2011 | 22177982 |
| the c-terminal domain of the adenomatous polyposis coli (apc) protein is involved in thyroid morphogenesis and function. | adenomatous polyposis coli (apc) is a multifunctional protein as well as a tumor suppressor. to determine the functions of the c-terminal domain of apc, we have investigated apc ( 1638t/1638t ) mice, which express a truncated apc that lacks the c-terminal domain. apc ( 1638t/1638t ) mice are tumor free and exhibit growth retardation. in the present ... | 2011 | 22179183 |
| the presence of facial nerve weakness on diagnosis of a parotid gland malignant process. | the objectives of this article are to assess the frequency and significance of facial paralysis and undiagnosed nerve infiltration in patients with parotid malignancies. 103 patients with parotid gland malignancies were treated in a single institution, the tertiary center for ent at the university department in poznan between 1996 and 2006. facial palsy at the initial presentation was found in 32 patients. the stage of the primary tumor in the examined group of 103 patients is as follows: 20-t1, ... | 2011 | 22179671 |
| serum insulin-like growth factors and mortality in localised and advanced clinically detected prostate cancer. | many studies have reported associations of insulin-like growth factors (igfs) and igf-binding proteins (igfbps) with prostate cancer development, but none have investigated their association with fatal progression of prostate cancer. | 2011 | 22183619 |
| endothelial dysfunction and subclinical hypothyroidism : a brief review. | subclinical hypothyroidism (sh) is characterized by normal serum free t4 (ft4) and free t3 (ft3) levels and increased serum thyroid-stimulating hormone (tsh) levels. the relationship between sh and cardiovascular diseases has been one of the most popular topics recently. there is still some controversy concerning the cardiovascular impact of sh and management protocols. the vast majority of the studies so far published suggests that sh accelerates endothelial dysfunction through traditional effe ... | 2011 | 22186427 |
| in vivo delivery of nucleic acids via glycopolymer vehicles affords therapeutic infarct size reduction in vivo. | using a new class of nontoxic and degradable glycopolymer-based vehicles termed poly(glycoamidoamine)s, we demonstrate virus-like delivery efficacy of oligodeoxynucleotide (odn) decoys to cardiomyoblasts (h9c2), primary cardiomyocytes, and the mouse heart. these glycopolymers bind and compact odn decoys into nanoparticle complexes that are internalized by the cell membrane and mediate nuclear uptake of dna in 90+% of cultured primary cardiomyocytes and 87% of the mouse myocardium. experimental r ... | 2011 | 22186793 |
| increased frequency of follicular helper t cells in patients with autoimmune thyroid disease. | context:follicular helper t (tfh) cells exert an important role in the autoimmune diseases.aim:our study aimed to explore the role of tfh cells in patients with autoimmune thyroid disease (aitd).design:tfh cell is a new subset regulating the antibody production of b cell. previous studies implicated cd4(+)cxcr5(+)icos(high) or cd4(+)cxcr5(+)pd-1(high) as the markers of circulating tfh cells. sixty-five patients with aitd and 30 healthy controls were enrolled in the current study. the percentages ... | 2011 | 22188745 |
| [The clinical effect of combination therapy for oral cancer with s-1, superselective intra-arterial chemotherapy, and radiation therapy]. | Combination therapy with S-1, superselective intra-arterial infusion of CBDCA and radiation therapy has been used to treat patients with oral cancer since 2005. In this study, the histopathological effects and toxicities following concurrent chemoradiotherapy were examined. The subjects consisted of 15 patients(10 men and 5 women)who were treated with S-1(60-80mg/day, 4 weeks), superselective intra-arterial infusion of CBDCA(300mg/body)and radiation therapy(total dose 30-36 Gy)in our department ... | 2011 | 22189221 |
| squamous carcinoma and dysplasia of the conjunctiva and cornea an analysis of 101 cases. | objective: to evaluate clinical and histopathologic factors of squamous conjunctival neoplasia associated with recurrence. design: retrospective, clinical case series. participants: one hundred one eyes of 99 patients with squamous conjunctival dysplasia, carcinoma in situ, or squamous cell carcinoma. methods: review of the medical records, pathology reports, and color photographs. main outcome measures: demographic information, laterality, tumor size, extension, pathologic diagnosis, seventh ed ... | 2011 | 22189448 |
| Geofold: Topology-based protein unfolding pathways capture the effects of engineered disulfides on kinetic stability. | Protein unfolding is modeled as an ensemble of pathways, where each step in each pathway is the addition of one topologically possible conformational degree of freedom. Starting with a known protein structure, GeoFold hierarchically partitions (cuts) the native structure into substructures using revolute joints and translations. The energy of each cut and its activation barrier are calculated using buried solvent accessible surface area, side chain entropy, hydrogen bonding, buried cavities, and ... | 2011 | 22189917 |
| probing the substrate specificity of the bacterial pnkp/hen1 rna repair system using synthetic rnas. | ribotoxins cleave essential rnas involved in protein synthesis as a strategy for cell killing. rna repair systems exist in nature to counteract the lethal actions of ribotoxins, as first demonstrated by the rna repair system from bacteriophage t4 25 yr ago. recently, we found that two bacterial proteins, named pnkp and hen1, form a stable complex and are able to repair ribotoxin-cleaved trnas in vitro. however, unlike the well-studied t4 rna repair system, the natural rna substrates of the bacte ... | 2011 | 22190744 |
| simulation of post-thyroidectomy treatment alternatives for t3 or t4 replacement in pediatric thyroid cancer patients. | background: as with adults, thyroidectomy of pediatric patients with differentiated thyroid cancer is often followed by 131i remnant ablation. a standard protocol is to give normalizing oral t4 or t3 after surgery and then withdraw it for 2 to 6 weeks. thyroid remnants or metastases are treated most effectively when serum tsh is high, but prolonged withdrawals should be avoided to minimize hypothyroid morbidity. methods: a published feedback control system model of adult human thyroid hormon ... | 2011 | 22191403 |
| overt and subclinical hypothyroidism: who to treat and how. | hypothyroidism denotes deficient production of thyroid hormone by the thyroid gland and can be primary (abnormality in thyroid gland itself) or secondary/central (as a result of hypothalamic or pituitary disease). the term 'subclinical hypothyroidism' is used to define that grade of primary hypothyroidism in which there is an elevated thyroid-stimulating hormone (tsh) concentration in the presence of normal serum free thyroxine (t4) and triiodothyronine (t3) concentrations. subclinical hypothyro ... | 2012 | 22191793 |
| how a dna polymerase clamp loader opens a sliding clamp. | processive chromosomal replication relies on sliding dna clamps, which are loaded onto dna by pentameric clamp loader complexes belonging to the aaa+ family of adenosine triphosphatases (atpases). we present structures for the atp-bound state of the clamp loader complex from bacteriophage t4, bound to an open clamp and primer-template dna. the clamp loader traps a spiral conformation of the open clamp so that both the loader and the clamp match the helical symmetry of dna. one structure reveals ... | 2011 | 22194570 |
| the ribosome modulates nascent protein folding. | proteins are synthesized by the ribosome and generally must fold to become functionally active. although it is commonly assumed that the ribosome affects the folding process, this idea has been extremely difficult to demonstrate. we have developed an experimental system to investigate the folding of single ribosome-bound stalled nascent polypeptides with optical tweezers. in t4 lysozyme, synthesized in a reconstituted in vitro translation system, the ribosome slows the formation of stable tertia ... | 2011 | 22194581 |
| Long-term skeletal and dental stability of mandibular symphyseal distraction osteogenesis with a hybrid distractor. | The purpose of this study was to examine the long-term skeletal and dental stability of mandibular symphyseal distraction osteogenesis (MSDO) with a tooth-borne and bone-borne hybrid distractor. To differentiate the effects of MSDO from the orthodontic movement and relapse, each phase of treatment was analyzed. | 2012 | 22196186 |
| health-related quality of life in patients with high-risk melanoma randomised in the nordic phase 3 trial with adjuvant intermediate-dose interferon alfa-2b. | purpose: to compare health-related quality of life (hrqol) and side-effects in patients with high-risk melanoma participating in a randomised phase iii trial of adjuvant interferon alfa-2b (ifn). patients and methods: a total of 855 patients with histologically verified resected cutaneous melanoma in ajcc stage iib (t4 n0 m0) or stage iii (tx n1-3 m0) were randomised to: arm a: observation only (n=284); arm b: 1-year treatment: induction: ifn alfa-2b, 10 mu (flat dose), sc, 5days/week, 4weeks, m ... | 2011 | 22196968 |
| characteristics of anemia in subclinical and overt hypothyroid patients. | thyroid hormones stimulate directly or indirectly growth of erythroid colonies through erythropoietin. anemia is often the first sign of hypothyroidism. hypothyroidism can cause a wide variety of anemic disorders. numerous mechanisms are involved in the pathogenesis of these anemias that can be microcytic, macrocytic and normocytic. we designed this study to investigate the anemia frequency and if present, etiology of anemia in hypothyroid patients. 100 patients with overt hypothyroid, 100 ... | 2011 | 22200582 |
| accuracy of multi-detector computed tomography (mdct) in staging of renal cell carcinoma (rcc): analysis of risk factors for mis-staging and its impact on surgical intervention. | objectives: to assess the accuracy of multi-detector computed tomography (mdct) in preoperative staging of renal cell carcinoma (rcc) and to detect the possible risk factors for mis-staging. in addition, the impact of radiological mis-staging on surgical decision and operative procedures was evaluated. materials and methods: data files of 693 patients, who underwent either radical or partial nephrectomy after pre ... | 2011 | 22200936 |
| [results of preoperative chemoradiotherapy for t4 rectal cancer]. | we reviewed clinical records of 11 cases with preoperative chemoradiotherapy to evaluate the clinical effectiveness of chemoradiotherapy for t4 rectal cancer. the preoperative radiotherapy consisted of 40-50 gy delivered in fractions of 1 .8- 2.0 gy per day, five days per week. a treatment of 5-fluorouracil, 500 mg/body per day intravenously, or oral uft-e (300 mg/m2) with l-leucovorin (75 mg) per day, or oral s-1 (80 mg/m2) per day five days per week, was given during radiotherapy. one patient ... | 2011 | 22202339 |
| [treatment strategy for stage ii/iii( non-t4)advanced esophageal cancer in high-risk patients]. | we evaluated treatment strategies for stage ii/iii( non-t4) advanced esophageal cancer in high-risk( hr) patients and analyzed the relationship between e-pass scoring system( e-pass) and hr patients retrospectively. the subjects were 85 patients who received the treatment for stage ii/iii( non-t4) advanced esophageal cancer between 2006 and 2010 in our institute. the patients were divided into the hr and non high-risk( nhr) group. in this study, hr patients were defined as satisfying at least on ... | 2011 | 22202389 |
| [A case of residual metastatic lymph node lesion following definitive chemoradiotherapy for t4 esophageal cancer, successfully treated by outpatient clinic-based sequential chemotherapy with docetaxel followed by s-1]. | Patients with T4 esophageal cancer generally have poor prognosis. Of these patients, prognosis of non-responder to chemoradiothrapy( CRT) is extremely poor. We report a case of residual lymph node metastasis following definitive CRT, which showed a good response to outpatient clinic-based chemotherapy consisting of docetaxel (DOC) followed by S-1 in a patient with T4 esophageal cancer. The patient was a 65-year-old man with the diagnosis of squamous cell carcinoma of the middle thoracic esophagu ... | 2011 | 22202394 |
| preliminary report--near total laryngectomy for scc larynx. | a retrospective analysis was performed on patients subjected to near-total laryngectomy at aga khan university hospital karachi from september 2006 and may 2010, to evaluate the functional outcome of near total laryngectomy and its effect on disease control. in all of these advanced stage laryngeal-hypopharyngeal squamous cancer patients, the disease was limited to one side of the larynx-hypopharynx. four patients were staged as t3 and rest were t4; near total laryngectomy was done in all 07 pat ... | 2011 | 22204224 |
| decreased levels of alternative co-stimulatory receptors ox40 and 4-1bb characterise t cells from head and neck cancer patients. | background and aim: head and neck cancers (hnc) are aggressive tumours. tumour-specific t cells are frequently identified in patients with cancer, although they fail to control tumour progression. a family of proteins called co-stimulatory receptors regulate the function of t cells and may account for t cell dysfunction in cancer. our aim was to characterise co-stimulatory receptors on t cells in hnc patients to identify novel targets for immunotherapy. methods: peripheral blood mononuclear cell ... | 2011 | 22204816 |
| Soft tissue stability in segmental distraction of the anterior mandibular alveolar process. A 2-year follow-up. | This study evaluated soft tissue changes in adult patients treated with distraction osteogenesis (DOG) of the anterior mandibular alveolar process and related it to different parameters. 33 patients (27 females; 6 males) were analysed retrospectively before surgery at T1 (17.0 days), after surgery at T2 (mean 6.5 days), at T3 (mean 24.4 days), and at T4 (mean 2.0 years). Lateral cephalograms were traced by hand, digitized, superimposed, and evaluated. Statistical analysis was carried out using K ... | 2011 | 22204924 |
| effects of the anti-thyroidal compound potassium-perchlorate on the thyroid system of the zebrafish. | the increasing pollution of aquatic habitats with anthropogenic compounds has led to various test strategies to detect hazardous chemicals. however, information on effects of pollutants in the thyroid system in fish, which is essential for growth, development and parts of reproduction, is still scarce. other vertebrate groups such as amphibians or mammals are well-studied; so the need for further knowledge especially in fish as a favored vertebrate model test organism is evident. modified early ... | 2011 | 22204988 |
| serum tsh level in healthy koreans and the association of tsh with serum lipid concentration and metabolic syndrome. | the proper treatment of subclinical hypothyroidism and the normal range of serum thyroid stimulating hormone (tsh) concentration are intensely debated. however, few reports have investigated tsh concentrations in asian ethnic groups. therefore, the present study was designed to define the tsh reference range in a korean population and to investigate the metabolic significance of tsh concentration. | 2011 | 22205844 |
| variations in vertebral body dimensions in women measured by 3d-xa: a longitudinal in vivo study. | bone size and shape play an important role in bone strength, as shown by biomechanical testing and clinical studies. vertebral body dimensions determine vertebral body strength even after adjustment for bone mineral density. we have recently proposed an in vivo method for 3d reconstruction of vertebral bodies using the whole spine imaging on a standard dxa device (3d-xa). the aim of our study was to measure in vivo vertebral body dimension changes by 3d-xa in women over a 6year period. a total o ... | 2011 | 22207276 |
| positive correlation between type 1 and 2 iodothyronine deiodinases activities in human goiters. | type 1 (d1) and 2 (d2) iodothyronine deiodinases are selenocysteine-containing enzymes that catalyze the deiodination of t4 to t3 in the thyroid and in peripheral tissues. despite their importance to the plasma t3 pool in human beings, there are few studies about their behavior in human thyroids. in order to better understand iodothyronine deiodinase regulation in the thyroid gland, we studied thyroid tissue samples from follicular adenoma (ad, n = 5), toxic diffuse goiter (tdg, n = 6), nontoxic ... | 2011 | 22207295 |
| structure and function of the small terminase component of the dna packaging machine in t4-like bacteriophages. | tailed dna bacteriophages assemble empty procapsids that are subsequently filled with the viral genome by means of a dna packaging machine situated at a special fivefold vertex. the packaging machine consists of a "small terminase" and a "large terminase" component. one of the functions of the small terminase is to initiate packaging of the viral genome, whereas the large terminase is responsible for the atp-powered translocation of dna. the small terminase subunit has three domains, an n-termin ... | 2011 | 22207623 |
| phase ii study of long-term androgen suppression with bevacizumab and intensity-modulated radiation therapy (imrt) in high-risk prostate cancer. | purpose: we report a phase ii trial assessing the acute and late toxicities of intensity-modulated radiation therapy (imrt), long-term androgen suppression (ltas), and bevacizumab in patients with high-risk localized prostate cancer. methods and materials: we treated 18 patients with ltas with bicalutamide and goserelin in combination with bevacizumab and imrt. bevacizumab (10 mg/kg every 2 weeks) was administered for the first 16 weeks, and 15 mg/kg was then given every 3 weeks for 12 additiona ... | 2011 | 22208976 |
| Ferrocene-functionalized SWCNT for electrochemical detection of T4 polynucleotide kinase activity. | A novel electrochemical strategy for monitoring the activity and inhibition of T4 polynucleotide kinase (PNK) is developed by use of titanium ion (Ti(4+)) mediated signal transition coupled with signal amplification of single wall carbon nanotubes (SWCNTs). In this method, a DNA containing 5'-hydroxyl group is self-assembled onto the gold electrode and used as substrate for PNK. The biofunctionalized SWCNTs with anchor DNA and ferrocene are chosen as the signal indicator by virtue of the intrins ... | 2011 | 22209074 |
| treatment outcomes and prognostic features in adenoid cystic carcinoma originated from the head and neck. | surgery is the main treatment modality for adenoid cystic carcinoma (acc) originated from the head and neck. however, the extensive local infiltrative and perineural spread related to this malignancy often cause difficulty to achieve high tumor control. the aim of this study is to evaluate the efficacy of postoperative radiotherapy (rt) in acc, and to identify prognostic variables associated with treatment outcomes. a retrospective review of 101 patients diagnosed with acc in the head and neck r ... | 2011 | 22209446 |
| The evaluation of SOX9 expression and its relationship with carcinoembryonic antigen-related cell adhesion molecule 1 in gastric neoplastic and nonneoplastic lesions. | The aims of this study were to investigate the expression of SOX9 (sex determining region Y [SRY]-related high-mobility group box 9) and carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in benign, premalignant, and malignant gastric lesions and to explore the association between SOX9 and CEACAM1 in gastric carcinogenesis. SOX9 and CEACAM1 expression was detected in normal gastric mucosa, hyperplastic polyp, intestinal metaplasia, gastric intraepithelial neoplasia, and adenocar ... | 2011 | 22209504 |
| upregulation of β2-microglobulin expression in progressive human oral squamous cell carcinoma. | the aim of the present study was to investigate β2-microglobulin (β2-m) expression in normal oral mucosa and progressive oral squamous cell carcinoma (oscc) and to assess the clinical significance of β2-microglobulin expression. the study included 10 cases of normal oral mucosa epithelium specimens, 55 cases of primary oscc specimens, and 25 cases of oscc metastasis specimens. immunohistochemistry was used to determine β2-m expression, ... | 2011 | 22211248 |
| effect of excess levels of lysine and leucine in wheat-based, amino acid-fortified diets on the mrna expression of two selected cationic amino acid transporters in pigs. | an experiment was conducted to evaluate the effect of excess levels of leu and lys on the expression of b(0,+) and cat-1 mrna in jejunum, liver and the muscles longissimus dorsi (ldm) and semitendinosus (stm). twenty pigs with an average initial bw of 16.4 ± 1.7 kg were used in a randomized complete block. dietary treatments (t) were as follows: t1, basal diet; t2, basal plus 3.5 g l-lys/kg diet; t3, basal plus 1.5 g l-leu/kg diet; t4, basal plus 3.5 g l-lys plus 1.5 g l-leu/kg diet. diets in t1 ... | 2011 | 22211733 |
| a population-based study of the pattern of terminal care and hospital death in patients with non-small cell lung cancer. | non-small cell lung cancer (nsclc) is a major cause of cancer-related death and utilization of health care resources worldwide. significant costs are generated in the months before death, with hospitalization being a major cost driver. moreover, hospital death causes physical and emotional distress. we analyzed factors predicting the likelihood of hospital death from nsclc. patients who died from nsclc (any stage and treatment) during the recent 5-year interval up to 31.12.2010, within a defined ... | 2012 | 22213306 |
| the role of adjuvant in mediating antigen structure and stability. | the purpose of this study was to probe the fate of a model antigen, a cysteine-free mutant of bacteriophage t4 lysozyme, to the level of fine structural detail, as a consequence of its interaction with an aluminum (al)-containing adjuvant. fluorescence spectroscopy and differential scanning calorimetry were used to compare the thermal stability of the protein in solution versus adsorbed onto an al-containing adjuvant. differences in accessible hydrophobic surface areas were investigated using an ... | 2011 | 22213631 |
| immune function in female b(6)c(3)f(1) mice is modulated by de-71, a commercial polybrominated diphenyl ether mixture. | polybrominated diphenyl ethers (pbdes) are an important class of flame-retardants that are environmentally persistent and bioaccumulative. toxicity of these compounds has become a concern because detectable levels of pbdes are present in humans and wildlife and they are structurally similar to polychlorinated biphenyls (pcbs). this study examined the effects of the commercial penta-bde mixture, de-71, in adult female b(6)c(3)f(1) mice on hematology, serum clinical chemistry, thyroid hormones, ti ... | 2012 | 22214215 |
| differences of the lymphatic distribution and surgical outcomes between remnant gastric cancers and primary proximal gastric cancers. | background: although remnant gastric cancer (rgc) following distal gastrectomy is located in the proximal stomach, little is known about the differences of the lymphatic distribution and surgical outcomes between rgc and primary proximal gastric cancer (pgc). methods: between 1997 and 2008, 1,149 patients underwent gastrectomy for gastric cancer. of these, 33 (2.9%) rgc patients and 207 (18.5%) pgc patients were ... | 2012 | 22215245 |
| alterations in tsh and thyroid hormones following mobile phone use. | in recent years, the widespread use of mobile phones has lead to a public debate about possible detrimental effects on human health. in spite of years of research, there is still a great controversy regarding the possibility of induction of any significant physiological effects in humans by microwave radiations emitted by mobile phones. this study aims to investigate the effects of electromagnetic fields induced by the global system for mobile communications (gsm) mobile phones on the thyroid st ... | 2009 | 22216380 |
| 3,5-diiodo-l-thyronine increases resting metabolic rate and reduces body weight without undesirable side effects. | recently, it was demonstrated that 3,5-diiodo-l-thyronine (t2) stimulates the resting metabolic rate (rmr), and reduces body-weight gain of rats receiving a high-fat diet. the aim of this study is to examine the effects of chronic t2 administration on basal metabolic rate and body weight in humans. two euthyroid subjects volunteered to undergo t2 administration. body weight, body mass index, blood pressure, heart rate, electrocardiogram, thyroid and liver ultrasonography, glycemia, total cholest ... | 2011 | 22217997 |
| tsh neurosecretory dysfunction (tsh-nd) in down syndrome (ds): low risk of progression to hashimoto's thyroiditis. | patients with down syndrome (ds) often have elevated tsh (hypothalamic origin), which is called tsh neurosecretory dysfunction (tsh-nd). in these cases, there is slight elevation in tsh (5-15 µui/ml), with normal free t4 and negative thyroid antibodies (ab). | 2011 | 22218446 |
| prognostic factors for locoregional recurrences in colon cancer. | background: there is increased interest in locoregional recurrences of rectal cancer. despite comparable locoregional recurrence rates in colon cancer, only a few studies on locoregional recurrences among colon cancer patients have been published. this study was designed to identify prognostic factors for locoregional recurrences among patients with colon cancer in the netherlands. methods: the study population w ... | 2012 | 22219065 |
| significance of a new fluorodeoxyglucose-positive lesion on restaging positron emission tomography/computed tomography after induction therapy for non-small-cell lung cancer. | restaging of patients with locally advanced non-small-cell lung cancer (nsclc) is of paramount importance, since only patients with down-staging after induction therapy will benefit from surgery. in this study, we assessed the aetiology of new (18)fluoro-2-deoxy-d-glucose (fdg)-positive focal abnormalities on restaging positron emission tomography/computed tomography (pet/ct) in patients with a good response after induction chemotherapy in the primary tumour and lymph nodes. | 2011 | 22219415 |
| long-term survival after lung-sparing total pleurectomy for locally advanced (international mesothelioma interest group stage t3-t4) non-sarcomatoid malignant pleural mesothelioma. | there is a body of opinion that advocates extrapleural pneumonectomy (epp) as the only radical treatment option for locally advanced (t3/t4) malignant pleural mesothelioma (mpm). we tested the hypothesis that lung-sparing total pleurectomy (lstp) can be as effective as epp in locally advanced mpm with reduced risk. | 2011 | 22219469 |
| the link between thyroid function and depression. | the relation between thyroid function and depression has long been recognized. patients with thyroid disorders are more prone to develop depressive symptoms and conversely depression may be accompanied by various subtle thyroid abnormalities. traditionally, the most commonly documented abnormalities are elevated t4 levels, low t3, elevated rt3, a blunted tsh response to trh, positive antithyroid antibodies, and elevated csf trh concentrations. in addition, thyroid hormone supplements appear to a ... | 2012 | 22220285 |
| the value of diagnostic whole-body scanning and serum thyroglobulin in the presence of elevated serum thyrotropin during follow-up of anti-thyroglobulin antibody-positive patients with differentiated thyroid carcinoma who appeared to be free of disease after total thyroidectomy and radioactive iodine ablation. | background: in the presence of anti-thyroglobulin antibodies (tgab), serum thyroglobulin (tg) might be underestimated. therefore, the american thyroid association does not recommend serum tg after thyroid hormone withdrawal or recombinant human thyrotropin administration (stimulated tg) and diagnostic whole-body scanning (dxwbs) in tgab-positive patients who have serum tg values while on thyroxine (tg-on-t4) of <1 ng/ml. the objective of this study was to determine, in patients with differentiat ... | 2012 | 22224815 |
| complete genome sequence and characterization of a broad-host range t4-like bacteriophage phias5 infecting aeromonas salmonicida subsp. salmonicida. | in this study, we report one lytic myoviridae bacteriophage (phage) infecting aeromonas salmonicida subsp. salmonicida. the phage (named as phias5) was isolated from environmental river waters in korea, and showed broad infectivity to other bacterial species in the family aeromonadaceae as well as antibiotic-resistant a. salmonicida subsp. salmonicida strains. the biological properties and complete genome of phias5 were simultaneously investigated. the complete genome of phias5 composed of linea ... | 2011 | 22226819 |
| low concentrations of bisphenol a suppress thyroid hormone receptor transcription through a nongenomic mechanism. | bisphenol (bpa) is one of the highest-volume chemicals produced worldwide, and human exposure to bpa is thought to be ubiquitous. various rodent and in vitro studies have shown that thyroid hormone (th) function can be impaired by bpa. however, it is still unknown if low concentrations of bpa can suppress the thyroid hormone receptor (tr) transcription. the present study aims to investigate the possible suppressing effects of low concentrations of bpa on tr transcription and the involved mechani ... | 2011 | 22227104 |
| single-port laparoscopic right hemicolectomy: the first 100 resections. | : single-port laparoscopy remains a novel technique in the field of colorectal surgery. several small series have examined its safety for colon resection. | 2012 | 22228155 |
| topical nitrogen mustard therapy in patients with mycosis fungoides or parapsoriasis. | background topical nitrogen mustard is a chemotherapeutic agent used in treatment of mycosis fungoides (mf). objective to evaluate the response and side effects in patients with mf and parapsoriasis treated with topical nitrogen mustard. methods a retrospective study of treatment response in 116 patients diagnosed with mf and 71 patients with parapsoriasis and treated with topical nitrogen mustard from 1991 to 2009. results overall response rate and complete response (cr) rate was 91.4% and ... | 2012 | 22229501 |
| [diffusion-weighted mr imaging in patients with rectal cancer: our initial experience]. | pre-surgical characterization of post-neoadjuvant residual tumor response in patients with rectal cancer by means of an imaging technique could be useful in order to determine the therapeutic strategy or observation. | 2011 | 22232997 |
| structural mechanism of the phosphorylation-dependent dimerization of the mdc1 forkhead-associated domain. | mdc1 is a key mediator of the dna-damage response in mammals with several phosphorylation-dependent protein interaction domains. the function of its n-terminal forkhead-associated (fha) domain remains elusive. here, we show with structural, biochemical and cellular data that the fha domain mediates phosphorylation-dependent dimerization of mdc1 in response to dna damage. crystal structures of the fha domain reveal a face-to-face dimer with pseudo-dyad symmetry. we found that the fha domain recog ... | 2012 | 22234877 |
| comparisons of polybrominated diphenyl ethers levels in paired south korean cord blood, maternal blood, and breast milk samples. | polybrominated diphenyl ethers (pbdes), commonly used flame retardants, have been reported as potential endocrine disruptor and neurodevelopmental toxicants, thus giving rise to the public health concern. the goal of this study was to investigate the relationship between umbilical cord blood, maternal blood, and breast milk concentrations of pbdes in south korean. we assessed pbde levels in paired samples of umbilical cord blood, maternal blood, and breast milk. the levels of seven pbde congener ... | 2012 | 22236587 |
| a systematic review and meta-analysis of the utility of eus for preoperative staging for gastric cancer. | background: accurate preoperative staging is important in determining the appropriate treatment of gastric cancer. recently, endoscopic ultrasound (eus) has been introduced as a staging modality. however, reported test characteristics for eus in gastric cancer vary. our purpose in this study was to identify, synthesize, and evaluate findings from all articles on the performance of eus in the preoperative staging of gastric cancer. met ... | 2012 | 22237654 |
| [myoepithelial carcinoma of salivary glands: a clinical analysis of 13 cases]. | this study retrospectively analyzed the clinical data of 13 patients with myoepithelial carcinoma of salivary glands for improving the accuracy of diagnosis and treatment outcome. | 2011 | 22241311 |
| deletion of the rnaseiii enzyme dicer in thyroid follicular cells causes hypothyroidism with signs of neoplastic alterations. | micro-rnas (mirnas) are small non-coding rnas that regulate gene expression, mainly at mrna post-transcriptional level. functional maturation of most mirnas requires processing of the primary transcript by dicer, an rnaseiii-type enzyme. to date, the importance of mirna function for normal organogenesis has been demonstrated in several mouse models of tissue-specific dicer inactivation. however, the role of mirnas in thyroid development has not yet been addressed. for the present study, we gener ... | 2012 | 22242190 |
| [clinical analysis of cervical lymph node metastasis of hypopharyngeal carcinoma]. | to investigate the pattern of cervical lymph node metastasis in hypopharyngeal carcinoma. | 2011 | 22242474 |
| [spectroscopic characteristics of dissolved organic matter in water from typical area of taihu lake]. | fluorescence spectroscopy, uv spectroscopy, and multiple uv parameters were applied to determine and analyze the dissolved organic matter (dom) in water of taihu lake, in order to find out the sources and influencing factors of dom in water from typical areas of taihu lake. the results showed that the components of dom in water from different lake areas displayed some regional characteristics. the contents of macro-molecules matters with complex structures and humic substances in water from samp ... | 2011 | 22242509 |
| role of spinal cord in regulating mouse kidney: a virally mediated trans-synaptic tracing study. | objective: to determine the spinal innervation and neuronal connections is important for studying renal metabolic responses. materials and methods: in this study, the spinal cords of 10 adult male c57bl/6j strain mice were mapped retrograde using injections of pseudorabies virus (prv)-614. the virus, injected into the kidney, was specifically transported to the spinal cord. results: at 5 days after injection of the prv-614, prv-614-positive cells were found in the intermediolateral cell column, ... | 2012 | 22245294 |
| creation and validation of a ligation-independent cloning (lic) retroviral vector for stable gene transduction in mammalian cells. | abstract: background: cloning vectors capable of retroviral transduction have enabled stable gene overexpression in numerous mitotic cell lines. however, the relatively small number of feasible restriction enzyme sequences in their cloning sites can hinder successful generation of overexpression constructs if these sequences are also present in the target cdna insert. results: utilizing ligation-independent cloning (lic) technology, we have modified the highly efficient retroviral transduction ... | 2012 | 22248071 |
| anaesthesia management for thyroidectomy in a non-euthyroid patient following cardiac failure. | a 24-year-old male thyrotoxic student of a tertiary institution had thyroidectomy in the presence of a persistently elevated thyroxine (t4) and tri-iodothyronine (t3) levels. he was initially managed for hypertension at a private hospital before he was referred to our hospital for expert management. he had symptoms of thyrotoxicosis three years before presentation at our hospital. physical examination revealed bilateral anterior neck masses and a diagnosis of toxic goitre was made. the serum t3 ... | 2011 | 22248956 |
| wheelchair half-marathon race increases natural killer cell activity in persons with cervical spinal cord injury. | study design:non-randomized study.objective:we reported that individuals with cervical spinal cord injury (csci) showed no increase in natural killer cell activity (nkca) in response to 20-min arm exercise. it could be argued that this lack of response was owing to the short duration and intensity of the exercise.setting:the 29th oita international wheelchair marathon race.methods:the present study compared the effects of wheelchair half-marathon race on natural killer (nk) cell count, nkca and ... | 2012 | 22249325 |
| the role of molecular markers and tumor histological type in central lymph node metastasis of papillary thyroid carcinoma. | to look for genetic mutations that might predict central compartment lymph node metastasis (lnm) in papillary thyroid carcinoma (ptc) using strict criteria for n0 and n1 disease. | 2012 | 22249628 |
| effects of fermented mushroom (flammulina velutipes) by-product diets on growth performance and carcass traits in growing-fattening berkshire pigs. | this study was conducted to investigate effects of fermented mushroom (flammulina velutipes) by-product diets on the growth performance and carcass traits in growing-fattening berkshire pigs. the fermented diets mainly contained 40.0% mushroom by-product, 20.0% formula feed, 26.0% rice bran and supplemental 0.1% probiotics. the mixed ingredients were fermented for 5days at room temperature. berkshire pigs (n=225) were divided into five groups and three replications. the basal diets (c) were subs ... | 2011 | 22250740 |
| serum transthyretin concentration is decreased in dogs with nonthyroidal illness. | background: hypothyroidism in dogs is often difficult to diagnose owing to nonspecific clinical signs and laboratory test results that can be mimicked by nonthyroidal illness (nti). thyroxine (t4) circulates in blood mainly bound to t4-binding globulin and, to a lesser degree, transthyretin (ttr) and albumin. the concentration of total t4 depends on the concentrations of these binding proteins. objectives: we hypothesized that dogs with nti and decreased serum total t4 concentrations would have ... | 2012 | 22250994 |
| segmental lesions in pityriasis rosea: a rare presentation. | a 34-year-old nonpregnant woman noted a mildly pruritic skin lesion on her right breast for 1 week following an episode of coryza, malaise, and low-grade fever of 3 days' duration. the latter symptoms subsided without any treatment. ketoconazole cream prescribed by her family physician did not resolve the breast eruption after 1 week, so was stopped. a week later, multiple skin lesions erupted suddenly on her right chest wall starting near the herald patch in midaxillary line and spread distally ... | 2011 | 22256628 |
| [the expression and its potentially clinical significance of epha2 in nasopharyngeal carcinoma]. | to observe the expression of epha2, and investigate its correlation with the development, progression, invasion, metastasis, angiogenesis and prognosis in nasopharyngeal carcinoma(npc). | 2011 | 22256737 |
| effectiveness of adjuvant chemotherapy with 5-fu/leucovorin and prognosis in stage ii colon cancer. | the aims of this study were to investigate the survival results and the prognostic factors of adjuvant chemotherapy in stage ii colon cancer in the sparsity of korean data. | 2011 | 22259748 |
| endoscopic vs transfacial resection of sinonasal adenocarcinomas. | objectives. compare the survival and the complication rates of 2 comparable groups of patients who underwent either endoscopic or transfacial resection of a sinonasal adenocarcinoma.study design. historical cohort study.setting. tertiary referral center.subjects and methods. twenty-four patients with sinonasal adenocarcinomas who recently underwent an endoscopy (the endo group, 1999-2009) were compared with 24 patients who underwent a lateral rhinotomy procedure (the lr group, 1993-2007). the pr ... | 2012 | 22261496 |
| [rocuronium vs vecuronium for neuromuscular block during transsternal thymectomy in the patient with myasthenia gravis]. | myasthenia gravis is an autoimmune disease marked by high titers of immunoglobulin g antibodies, which accelerate destruction of cholinergic receptors and interfere with neuromuscular transmission. this study aimed to determine whether neuromuscular function under a rocuronium block is different from function under a vecuronium block patients with myasthenia gravis and to describe extubation conditions in the operating room or the intensive care unit. | 2011 | 22263401 |