Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| preoperative evaluation of the depth of anal canal invasion in very low rectal cancer by magnetic resonance imaging and surgical indications for intersphincteric resection. | purpose: the present study was performed to evaluate the depth of anal canal invasion (daci), and determine whether magnetic resonance imaging (mri) assessment of the conjoined longitudinal muscle (clm) can be used to identify the surgical indication for intersphincteric resection. methods: sixty-six patients with t1 (n = 2), t2 (n = 20), t3 (n = 39), and t4 (n = 5) lower rectal cancer were included. depth of ana ... | 2011 | 22075666 |
| quantitative electroencephalography in schizophrenia and depression. | standard (qualitative) electroencephalography (eeg) is routinely used in the diagnostic evaluation of psychiatric patients. quantitative eeg (qeeg) findings differ between patients with schizophrenia, patients with depression, but results are not consistent. the aim of our study was to determine the differences in qeeg parameters between patients with schizophrenia, patients with depression, and healthy subjects. | 2011 | 22075736 |
| Prospective trial of chemotherapy-enhanced accelerated radiotherapy for larynx preservation in patients with intermediate-volume hypopharyngeal cancer. | BACKGROUND: Altered fractionation radiotherapy (RT) improves locoregional control in head and neck cancer without aggravation of late adverse events. To improve successful larynx-preservation rates in patients with resectable, intermediate-volume hypopharyngeal cancer, a prospective trial of chemotherapy-enhanced accelerated RT was conducted. METHODS: Patients with T2 to T4 hypopharyngeal cancer received 40 Gray (Gy)/4 weeks to the entire neck followed by boost RT administering 30 Gy/2 weeks (1. ... | 2011 | 22076936 |
| laminectomy, durotomy, and piotomy effects on spinal cord intramedullary pressure in severe cervical and thoracic kyphotic deformity: a cadaveric study. | object previous studies have shown that cervical and thoracic kyphotic deformity increases spinal cord intramedullary pressure (imp). using a cadaveric model, the authors investigated whether posterior decompression can adequately decrease elevated imp in severe cervical and thoracic kyphotic deformities. methods using an established cadaveric model, a kyphotic deformity was created in 16 fresh human cadavers (8 cervical and 8 thoracic). a single-level rostral laminotomy and durotomy we ... | 2011 | 22077470 |
| our experience in the treatment advanced neoplasms of floor of the mouth. | aim: the aim of this study was to evaluate results of our surgical treatment of advanced neoplasms of the floor of the mouth, treated from 2005-2011 in department of otolaryngology and department of plastic surgery medical university of gdańsk material: we analyzed group of 12 patients (aged 36 to 70 years, mean 55) treated by primary surgical excision of neoplasms of the floor of the mouth (with tracheotomy and mandibulotomy) and selective or radical neck dissection (uni- or bilateral) in combi ... | 2011 | 22078284 |
| a phase ii trial of radiation therapy and weekly cisplatin chemotherapy for the treatment of locally-advanced squamous cell carcinoma of the vulva: a gynecologic oncology group study. | objectives: to determine the efficacy and toxicity of radiation therapy and concurrent weekly cisplatin chemotherapy in achieving a complete clinical and pathologic response when used for the primary treatment of locally-advanced vulvar carcinoma. methods: patients with locally-advanced (t3 or t4 tumors not amenable to surgical resection via radical vulvectomy), previously untreated squamous cell carcinoma of the vulva were treated with radiation (1.8gy daily×32 fractions=57.6gy) plus weekly cis ... | 2011 | 22079361 |
| Plasma progesterone, metabolic hormones and beta-hydroxybutyrate in Holstein-Friesian cows after superovulation. | Metabolic hormones [insulin, leptin, insulin-like growth factor-I (IGF-I), thyroxine (T4) and triiodothyronine (T3)], progesterone (P4) and beta-hydroxybutyrate (BHB) serum concentrations were evaluated and their effect on the superovulation results of donor cows was investigated in a semi-arid environment. Body weight, body condition score (BCS) and lactation stage were also included in the analysis. Twenty-three Holstein-Friesian cows were superovulated with 600 IU FSHp following the routine p ... | 2011 | 22079709 |
| four-week neoadjuvant intensity-modulated radiation therapy with concurrent capecitabine and oxaliplatin in locally advanced rectal cancer patients: a validation phase ii trial. | purpose: to validate tolerance and pathological complete response rate (pcr) of a 4-week preoperative course of intensity-modulated radiation therapy (imrt) with concurrent capecitabine and oxaliplatin (capox) in patients with locally advanced rectal cancer. methods and materials: patients with t3 to t4 and/or n+ rectal cancer received preoperative imrt (47.5 gy in 19 fractions) with concurrent capecitabine (825 mg/m(2) b.i.d., monday to friday) and oxaliplatin (60 mg/m(2) on days 1, 8, and 15). ... | 2011 | 22079731 |
| site-specific isotope labeling of long rna for structural and mechanistic studies. | a site-specific isotope labeling technique of long rna molecules was established. this technique is comprised of two simple enzymatic reactions, namely a guanosine transfer reaction of group i self-splicing introns and a ligation with t4 dna ligase. the trans-acting group i self-splicing intron with its external cofactor, 'isotopically labeled guanosine 5'-monophosphate' (5'-gmp), steadily gave a 5'-residue-labeled rna fragment. this key reaction, in combination with a ligation of 5'-remainder n ... | 2012 | 22080547 |
| Statistical mechanics and molecular dynamics in evaluating thermodynamic properties of biomolecular recognition. | Molecular recognition plays a central role in biochemical processes. Although well studied, understanding the mechanisms of recognition is inherently difficult due to the range of potential interactions, the molecular rearrangement associated with binding, and the time and length scales involved. Computational methods have the potential for not only complementing experiments that have been performed, but also in guiding future ones through their predictive abilities. In this review, we discuss h ... | 2011 | 22082669 |
| medical image analysis: computer-aided diagnosis of gastric cancer invasion on endoscopic images. | background: the aim of this study was to investigate the efficacy of diagnosing depth of wall invasion of gastric cancer on endoscopic images using computer-aided pattern recognition. methods: the back propagation algorithm was used for computer training. data of 344 patients who underwent gastrectomy or endoscopic tumor resection between 2001 and 2010 and their 902 endoscopic images were collected. the images we ... | 2011 | 22083334 |
| Malignant melanoma in the elderly: different regional disease and poorer prognosis. | Purpose: Age is a poor prognostic factor in melanoma patients. Elderly melanoma patients have a different presentation and clinical course than younger patients. We evaluated the impact of age =70 years (yrs) on the diagnosis and natural history of melanoma.Methods: Retrospective review of 610 patients with malignant melanoma entered into a prospective sentinel lymph node (SLN) database, treated from June 1997 to June 2010. Disease characteristics and clinical outcomes were compared between pati ... | 2011 | 22084644 |
| differentiated thyroid cancer in navarra (spain): historic cohort results (1987-2003). | introduction. navarra has the highest incidence of differentiated thyroid cancer in spain. the aim of this study was to review its management carried out by the navarra's multidisciplinary thyroid disease unit, from 1987 to 2003. material and methods. 325 patients were studied to find the incidence, prevalence, and prognostic factors. statistical analysis comprised univariate and multivariate cox proportional hazards regression models for survival and tumor recurrence. results. the average annua ... | 2011 | 22084734 |
| locally advanced prostate cancer: a population-based study of treatment patterns. | study type - therapy (practice patterns) level of evidence 2b what's known on the subject? and what does the study add? the treatment of locally advanced prostate cancer varies widely even though there is level one evidence supporting the use of multimodality therapy as compared with monotherapy. this study defines treatment patterns of locally advanced prostate cancer within the united states and identifies predicators of who receives multimodality therapy rather than monotherapy. objective: • ... | 2011 | 22085255 |
| Plasmatic vasopressin in patients undergoing conventional infra-renal abdominal aorta aneurysm repair. | To evaluate plasmatic arginine vasopressin (AVP) levels in patients undergoing scheduled conventional abdominal aortic aneurysm (AAA) repair. | 2011 | 22086577 |
| positive lymphoscintigraphy (ils) and negative computed tomography for metastatic penile cancer. | penile carcinoma usually occurs in older than 40 years men with an incidence in western communities of 0.5 to 1.6 per 100,000 men per year while in developing countries the rate is much higher in men. extensive lymph node dissection of lymphatic inguinal metastases evident by inguinal lymphoscintigraphy (ils) induces improved overall survival. a 75 years old male with penile squamous cell carcinoma stage pt2n0m0 of less than 2cm diameter, with tumor invasion of the penis corpora underwent parti ... | 2011 | 22087456 |
| The population level prevalence and correlates of appropriate and inappropriate imaging to stage incident prostate cancer in the medicare population. | According to guidelines most men with incident prostate cancer do not require staging imaging. We determined the population level prevalence and correlates of appropriate and inappropriate imaging in this cohort. | 2012 | 22088337 |
| Cord blood levels of thyroid hormones and IGF-1 weakly correlate with breast milk levels of PBDEs in Taiwan. | In vivo studies indicate that prenatal or neonatal exposure of rodents to polybrominated diphenyl ethers (PBDEs) disrupts thyroid hormone balance, but few studies have reported an association of PBDEs and insulin-like growth factor 1 (IGF-1). The goal was to examine whether PBDEs exposure affects the levels of thyroid hormones and IGF-1 in cord blood. Study participants were healthy pregnant women recruited from the general population in central Taiwan between 2000 and 2001 and in southern Taiwa ... | 2011 | 22088798 |
| Is celiac axis resection justified for T4 pancreatic body cancer? | The clinical impact of the distal pancreatectomy with en-bloc celiac axis resection for locally advanced pancreatic body cancer remains unclear. | 2012 | 22088810 |
| anthrax vaccine antigen-adjuvant formulations completely protect new zealand white rabbits against challenge with bacillus anthracis ames strain spores. | in an effort to develop an improved anthrax vaccine that shows high potency, five different anthrax protective antigen (pa)-adjuvant vaccine formulations that were previously found to be efficacious in a nonhuman primate model were evaluated for their efficacy in a rabbit pulmonary challenge model using bacillus anthracis ames strain spores. the vaccine formulations include pa adsorbed to alhydrogel, pa encapsulated in liposomes containing monophosphoryl lipid a, stable liposomal pa oil-in-water ... | 2012 | 22089245 |
| acanthamoeba belonging to t3, t4, and t11: genotypes isolated from air-conditioning units in santiago, chile. | free-living amoebae (fla) of the genus acanthamoeba are widely distributed in the environment, in the air, soil, and water, and have also been isolated from air-conditioning units. the objective of this work was to investigate the presence of this genus of fla in the air-conditioning equipment at the institute of public health of chile in santiago, chile. water and air samples were collected from air-conditioning systems and were checked for the presence of acanthamoeba spp. positive samples wer ... | 2011 | 22092528 |
| EFFECT OF GLUCOCORTICOID ADMINISTRATION ON ADRENAL GLAND SIZE AND SONOGRAPHIC APPEARANCE IN BEAGLE DOGS. | Our aim was to evaluate the influence of glucocorticoids on the adrenal gland using ultrasonography. Eleven healthy beagles were used in a prospective placebo-controlled study. All dogs received hydrocortisone at 10 mg/kg twice a day per os for 4 months or a gelatin capsule twice a day per os as a placebo. Clinical and endocrinologic examination of the dogs and ultrasonographic evaluation of adrenal echogenicity, shape, and measurement of the length and height of the cranial and caudal pole were ... | 2011 | 22092685 |
| clinical pathology of greyhounds and other sighthounds. | owing to the development of greyhounds as racing sighthounds, these dogs have acquired unique physiologic adaptations that distinguish them from other breeds. reference intervals for many analytes in retired racing greyhounds (rrgs) differ from those of other breeds; most of the hematologic differences have also been described in other sighthounds. in this review, we provide a survey of the literature on clinical pathology of greyhounds and other sighthounds and results of laboratory testing, in ... | 2011 | 22092909 |
| Comparison of endocrine-mediated effects of two bisphenol A related compounds, 2,2-bis(4-cyanatophyenyl)propane and 4,4'-cyclohexylidenebisphenol, based on subacute oral toxicity studies using rats. | The purpose of this study was to compare endocrine-mediated effects of bisphenol A related compounds, 2,2-bis(4-cyanatophyenyl)propane and 4,4'-cyclohexylidenebisphenol with reference to OECD Test Guideline No. 407. Rats were orally gavaged with 0, 4, 20, and 100mg/kg/day of 2,2-bis(4-cyanatophyenyl)propane, and 0, 30, 100, and 300mg/kg/day of 4,4'-cyclohexylidenebisphenol for at least 28 days beginning at 8 weeks of age. Endocrine-mediated effects were not observed in rats given 2,2-bis(4-cyana ... | 2012 | 22093917 |
| [Effects of incretion hormones on growth pituitary adenoma ectomy and evaluation of long-term therapeutic efficacy]. | To investigate the effect of incretion hormones on growth pituitary adenoma ectomy patients and evaluate its long-term therapeutic efficacy. | 2011 | 22094038 |
| effect of different propranolol doses on skeletal structural and mechanic efficiency in an animal model of growth retardation. | objective: to assess in a growth retardation (gr) model the impact of different propranolol (p) doses on anthropomorphometric and biomechanical variables of the appendicular skeleton. materials and methods: twenty-one day-old male wistar rats were divided into the following groups: control (c), c+p3.5 (cp3.5); c+p7 (cp7); c+p10.5 (cp10.5); c+p14 (cp14); ed, ed+p3.5 (edp3.5); ed+p7 (edp7); ed+p10.5 (edp10.5), and ed+p14 (edp14). control animals with/without p were fed a rodent diet ad libitum. gr ... | 2011 | 22094148 |
| phase ii trial of preoperative paclitaxel, gemcitabine, and trastuzumab combination therapy in her2 positive stage ii/iii breast cancer: the korean cancer study group br 07-01. | an addition of trastuzumab preoperatively to chemotherapy for human epidermal growth factor receptor 2 (her2) positive breast cancer improved relapse-free survival (rfs). this study was designed to evaluate the efficacy and safety of preoperative paclitaxel, gemcitabine, and trastuzumab (pgh) combination for her2-positive breast caner. pathologically, proven node positive stage ii/iii breast cancer patients with adequate organ function and no history of anti-cancer therapy were eligible. patient ... | 2011 | 22094934 |
| 5'cag and 5'ctg repeats create differential impediment to the progression of a minimal reconstituted t4 replisome depending on the concentration of dntps. | instability of repetitive sequences originates from strand misalignment during repair or replicative dna synthesis. to investigate the activity of reconstituted t4 replisomes across trinucleotide repeats (tnrs) during leading strand dna synthesis, we developed a method to build replication miniforks containing a tnr unit of defined sequence and length. each minifork consists of three strands, primer, leading strand template, and lagging strand template with a 5' single-stranded (ss) tail. each s ... | 2011 | 22096622 |
| [t3, t4 pathologic fracture with incompletely paralysis caused by langerhans cell histiocytosis: a case report]. | 2011 | 22097135 | |
| [sentinel lymph node biopsy as a new approach to colorectal cancer treatment]. | some concepts considering sentinel lymph node excision in colon and rectal carcinoma are presented in the paper. arguments pro and contra were exposed and interpret separately. the problem is still open. current knowledge indicates that lymphatic system in colon and rectum can be very different in many patients. there is no evidence that sentinel node biopsy in this group can be useful. in patients with advanced colorectal carcinoma (t3, t4 according to tnm classification) sentinel node biopsy c ... | 2011 | 22097185 |
| [clinical study of safflower injection in treating and preventing the vascular crisis after free flap transplantation]. | to observe the clinical efficacy of safflower injection (al) in treating and preventing the vascular crisis after free flap transplantation. | 2011 | 22097197 |
| Retrospective evaluation of the use of amiodarone in dogs with arrhythmias (from 2003 to 2010). | Objectives: To evaluate the efficacy of amiodarone in dogs with refractory supraventricular and ventricular arrhythmias and to document the side effects in treated dogs. Methods: Records of 28 dogs were retrospectively searched to document indication for amiodarone administration, heart rate, alkaline phosphatase, alanine aminotransferase, thyroxine (T4) and thyroid stimulating hormone values before and after starting treatment and during follow-up periods. Results: Sixteen dogs with supraventri ... | 2011 | 22098072 |
| clinicopathological and prognostic role of cyclin d1 in esophageal squamous cell carcinoma: a meta-analysis. | cyclin d1 is one of the most commonly over-expressed oncogenes; however, its role in esophageal squamous cell carcinoma (escc) remains controversial. we conducted a meta-analysis of 20 studies, comprising 2,041 patients to clarify this issue. in all studies, paraffin-embedded surgical specimens were collected and the status of cyclin d1 was determined by immunohistochemistry (ihc). the combined odds ratios (ors) for cyclin d1 expression were 0.74 (95% confidence interval [ci]: 0.58-0.93) for wel ... | 2011 | 22098104 |
| [Overgrowth with and without obesity: clinical and molecular principles.] | Somatic overgrowth is a complex and heterogeneous pathology that is only partially understood, although developments in molecular biology have allowed the discovery of the aetiological basis of some of these conditions. The differential diagnosis of a patient with a possible variant of normality, a chromosomopathy, a dysmorphic syndrome, a metabolic or an endocrine disease is essential. The initial clinical evaluation should include a correct anamnesis and physical examination, as well as comple ... | 2011 | 22098786 |
| gastric cancer eastern experience. | several guidelines are used for cancer therapy throughout the world. the japan gastric cancer association guideline, whereby standard surgery for t2 to t4 curable gastric cancer is defined as more than two-thirds gastrectomy with d2 dissection, are widely followed, with further data being gathered from either single institutions or nationwide registry. in the east, d2 dissection shows much better results than less extended surgery followed by adjuvant treatment. adjuvant chemotherapy without rad ... | 2012 | 22098832 |
| Outcome of T4 (International Union Against Cancer Staging System, 7th edition) or Recurrent Nasal Cavity and Paranasal Sinus Carcinoma Treated with Proton Beam. | PURPOSE: To investigate the clinical features, prognostic factors, and toxicity of treatment for unresectable carcinomas of the nasal cavity and paranasal sinus (NCPS) treated with proton beam therapy (PBT). METHODS AND MATERIALS: Seventeen patients (13 men, 4 women) with unresectable carcinomas of the NCPS who underwent PBT at the University of Tsukuba between 2001 and 2007 were analyzed. The patients' median age was 62 years (range, 30-83 years). The tumors were located in the nasal cavity in ... | 2011 | 22099036 |
| aluminium effects on thyroid gland function: iodide uptake, hormone biosynthesis and secretion. | the effects of aluminium (al) on thyroid function were evaluated in adult wistar rats intraperitoneally (i.p) injected with 7 mg al (as lactate)/kg body weight (b.w) per day during a six week period. the time-course kinetics of na(125)i (3 μci per 100 g b.w, i.p) was analysed by measuring gamma-radioactivity of thyroid, serum, serum protein precipitate and bile, at times ranging from 2 to 96 h post-dosing. in al-treated group the (125)i(-) thyroid uptake at 24 h (15,840 ± 570 vs. 18,030 ± 630 dp ... | 2011 | 22099156 |
| P-selectin, E-selectin, and CD40L over time in chronic hemodialysis patients. | The aim of this study was to measure P-selectin, E-selectin, and CD-4L levels over time in chronic hemodialysis (HD) patients. Thirty stable patients with end-stage renal failure undergoing chronic HD were included in the study. Blood samples were obtained before HD for measurement of P-selectin, E-selectin, and CD-40L. Measurements were performed at month 0 (T0), 3 (T2), 8 (T3), and 13 (T4). The levels of P-selectin, E-selectin, and CD40L were also analyzed according to the occurrence of cardio ... | 2011 | 22099468 |
| neuropsychological function in patients who have had epilepsy surgery: a long-term follow-up. | we examined the relationship between seizure outcomes and long-term changes in memory and intellectual function in 70 patients who had undergone temporal lobe resection for medically intractable epilepsy. patients were assessed on four occasions: preoperatively (t1), 3months postoperatively (t2), 1year postoperatively (t3), and more than 5years postoperatively (t4). the majority of patients had stable memory function across the assessments. however, many were functioning below the 15th percentil ... | 2011 | 22100066 |
| adenine recognition is a key checkpoint in the energy release mechanism of phage t4 dna packaging motor. | atp is the source of energy for numerous biochemical reactions in all organisms. tailed bacteriophages use atp to drive powerful packaging machines that translocate viral dna into a procapsid and compact it to near-crystalline density. here we report that a complex network of interactions dictates adenine recognition and atp hydrolysis in the pentameric phage t4 large "terminase" (gp17) motor. the network includes residues that form hydrogen bonds at the edges of the adenine ring (q138 and q143) ... | 2011 | 22100308 |
| individualised isotoxic accelerated radiotherapy and chemotherapy are associated with improved long-term survival of patients with stage iii nsclc: a prospective population-based study. | background: individualised, isotoxic, accelerated radiotherapy (indar) allows the delivery of high biological radiation doses, but the long-term survival associated with this approach is unknown. methods: patients with stage iii nsclc in the netherlands cancer registry/limburg from january 1, 2002 to december 31, 2008 were included. results: patients (1002) with stage iii nsclc were diagnosed, of which 938 had t4 and/or n2-n3 disease. patients treated with curative intent were staged with fdg-pe ... | 2011 | 22100659 |
| Determinants of the cytotoxicity of PrrC anticodon nuclease and its amelioration by tRNA repair. | Breakage of tRNA(Lys(UUU)) by the Escherichia coli anticodon nuclease PrrC (EcoPrrC) underlies a host antiviral response to phage T4 infection that is ultimately thwarted by a virus-encoded RNA repair system. PrrC homologs are prevalent in other bacteria, but their activities and substrates are not defined. We find that induced expression of EcoPrrC is toxic in Saccharomyces cerevisiae and E. coli, whereas the Neisseria meningitidis PrrC (NmePrrC) is not. PrrCs consist of an N-terminal NTPase mo ... | 2012 | 22101242 |
| number of lymph nodes retrieved is an important determinant of survival of patients with stage ii and stage iii colorectal cancer. | the number of lymph nodes retrieved is recognized to be a prognostic factor of stage ii colorectal cancer. however, the prognostic significance of the number of lymph nodes retrieved in stage iii colorectal cancer remains controversial. | 2012 | 22102737 |
| towards a structural comprehension of bacterial type vi secretion systems: characterization of the tssj-tssm complex of an escherichia coli pathovar. | type vi secretion systems (t6ss) are trans-envelope machines dedicated to the secretion of virulence factors into eukaryotic or prokaryotic cells, therefore required for pathogenesis and/or for competition towards neighboring bacteria. the t6ss apparatus resembles the injection device of bacteriophage t4, and is anchored to the cell envelope through a membrane complex. this membrane complex is composed of the tssl, tssm and tagl inner membrane anchored proteins and of the tssj outer membrane lip ... | 2011 | 22102820 |
| estimation of stature from the foot and its segments in a sub-adult female population of north india. | abstract: | 2011 | 22104433 |
| the biomechanics of the pediatric and adult human thoracic spine. | a growing body of literature points out the relevance of the thoracic spine dynamics in understanding the thorax-restraint interaction as well as in determining the kinematics of the head and cervical spine. this study characterizes the dynamic response in bending of eight human spinal specimens (4 pediatric: ages 7 and 15 years, 4 adult: ages 48 and 52 years) from two sections along the thoracic spine (t2-t4 and t7-t9). each specimen consisted of three vertebral bodies connected by the correspo ... | 2011 | 22105396 |
| intensity-modulated radiotherapy combined with chemotherapy for the treatment of gastric cancer patients after standard d1/d2 surgery. | the purpose of the current study is to evaluate the efficacy and complications of concurrent chemoradiotherapy (ccrt) for the treatment of gastric cancer patients after d1/d2 surgery. | 2011 | 22105898 |
| oxidative stress following administration of levothyroxine in subjects suffering from primary hypothyroidism. | oxidative stress (os) in subjects with primary hypothyroidism under therapy with l-t4 might be the cause of the side effects commonly found with this treatment. | 2011 | 22108484 |
| Activity of some physiological modulators in reducing the side effects of levothyroxine in patients suffering from primary hypothyroidism. | The use of L-T4 (levothyroxine) in the treatment of primary hypothyroidism causes oxidative stress (OS) and daily discomfort. It is believed that the use of physiological modulators (PMs) may make the treatment more tolerable. | 2011 | 22108485 |
| The miR-143/-145 cluster regulates plasminogen activator inhibitor-1 in bladder cancer. | Background:Upregulation of the proto-oncogene plasminogen activator inhibitor-1 (PAI-1) is a common hallmark of various solid tumours, but the mechanisms controlling its expression are not fully understood.Methods:We investigate microRNAs (miRNAs) regulating PAI-1 in a panel of normal bladder urothelial biopsies, superficial Ta bladder tumours and invasive T1-T4 tumours using expression microarrays and qRT-PCR. The prognostic implications of PAI-1 deregulation are established by tissue microarra ... | 2011 | 22108519 |
| sephardic signature in haplogroup t mitochondrial dna. | a rare combination of mutations within mitochondrial dna subhaplogroup t2e is identified as affiliated with sephardic jews, a group that has received relatively little attention. four investigations were pursued: search of the motif in 250 000 control region records across 8 databases, comparison of frequencies of t subhaplogroups (t1, t2b, t2c, t2e, t4, t(*)) across 11 diverse populations, creation of a phylogenic median-joining network from public t2e control region entries, and analysis of on ... | 2011 | 22108605 |
| the effect of heating insufflation gas on acid-base alterations and core temperature during laparoscopic major abdominal surgery. | carbon dioxide (co(2)) has different biophysical properties under different thermal conditions, which may affect its rate of absorption in the blood and the related adverse events. the present study was aimed to investigate the effects of heating of co(2) on acid-base balance using stewart's physiochemical approach, and body temperature during laparoscopy. | 2011 | 22110878 |
| UV-induced DNA damage and DNA repair in ribosomal genes chromatin. | Cyclobutane pyrimidine dimers (CPDs) and (6,4) pyrimidine-pyrimidone dimers are the major DNA lesions (or photoproducts) induced by ultraviolet light and are removed by the nucleotide excision repair (NER) pathway. If not repaired, DNA damage can lead to genome instability. The genome is organized into nuclear domains with distinct functions and chromatin structures. Although studies on NER in all chromosomal contexts are important to understand the mechanisms of genome maintenance, we focused o ... | 2012 | 22113285 |
| advanced maxillary sinus cancer treated with concurrent chemoradiotherapy with intra-arterial cisplatin/docetaxel and oral s-1: own experience and literature review. | intra-arterial (ia) chemotherapy for head and neck cancer is effective and multiple ia concurrent chemoradiation (ccrt) protocols have been reported. however, the role of ia ccrt in the multimodality treatment of head and neck cancer is still controversial. we have treated 5 cases of unresectable t4 maxillary sinus squamous cell carcinoma with ia cisplatin (cddp) and docetaxel (doc) and ccrt with oral s-1. we report our experience and the effectiveness and feasibility of this combination as an a ... | 2011 | 22114575 |
| complete genomic sequence of a t4-like bacteriophage, phias4, infecting aeromonas salmonicida subsp. salmonicida. | a newly identified virulent phage (named phias4) infecting aeromonas salmonicida subsp. salmonicida was isolated from river water in korea. morphological analysis of phias4 by transmission electron microscopy revealed that it belonged to the family myoviridae. the genome of phias4 comprised a linear double-stranded dna of 163,875 bp with a g + c content of 41.3%, and genomic analysis revealed 271 putative orfs, 67 putative promoters, 25 putative terminator regions, and 16 trna-encoding genes. mo ... | 2011 | 22116495 |
| clinicopathological features and prognostic factors of gastric cancer patients aged 40 years or younger. | background and objectives: gastric adenocarcinoma (gc) occurs frequently in the sixth decade of life and is uncommon in patients aged 40 years or younger. the aims of this study were to define the clinicopathological features and elucidate the prognostic factors of gc in the young. methods: between 1998 and 2006, 1,815 gc patients undergoing resection were enrolled in a prospective database. the findings for 115 (6.0%) patients aged 40 years or younger were compared with those of 1,009 patients ... | 2011 | 22116742 |
| A phase III trial of docetaxel-estramustine in high-risk localised prostate cancer: A planned analysis of response, toxicity and quality of life in the GETUG 12 trial. | To assess docetaxel-estramustine in patients with localised high-risk prostate cancer. | 2012 | 22119204 |
| spinal pilocytic astrocytoma in an elderly patient. | objective: astrocytomas are the most common intramedullary spinal cord tumor (imsct) in pediatric and adolescent patients and the incidence decreases with age. there are very few cases of spinal pilocytic astrocytomas (who grade 1) reported after the fourth decade. we report the oldest known case of a pathologically confirmed spinal pilocytic astrocytoma. methods: a 78-year-old female presented with 12 months of bilateral lower extremity numbness. magnetic resonance imaging (mri) revealed cord e ... | 2011 | 22120566 |
| Sensillum-specific, topographic projection patterns of olfactory receptor neurons in the antennal lobe of the cockroach Periplaneta americana. | In vertebrates and many invertebrates, olfactory signals detected by peripheral olfactory receptor neurons (ORNs) are conveyed to a primary olfactory center with glomerular organization in which odor specific activity patterns are generated. In the cockroach, Periplaneta americana, ORNs in antennal olfactory sensilla project to 205 unambiguously identifiable antennal lobe (AL) glomeruli that are classified into 10 glomerular clusters (T1-T10 glomeruli) innervated by distinct sensory tracts. In t ... | 2011 | 22121009 |
| Postmenopausal women with osteoporosis and musculoskeletal status: a comparative cross-sectional study. | With increased life expectancy of the world's population that has taken place in recent decades, there has been growth in the incidence of illnesses of the most advanced ages, including osteoporosis. However, changes in musculoskeletal disorders are not yet so clear. This study proposes to evaluate musculoskeletal alterations in osteoporotic postmenopausal women and healthy and correlate with bone mineral density of the lumbar spine. | 2011 | 22121400 |
| tai chi () pedicle screw placement for severe scoliosis. | study design:: retrospective. objective:: to evaluate the clinical safety and accuracy of the tai chi () technique for placing pedicle screws, without intraoperative radiographic imaging, in severe scoliotic spines. summary of background data:: the current techniques for pedicle screw placement have a number of drawbacks in cases of severe scoliosis, including difficulty or impossibility to use, delayed operative time, requiring the presence of trained personnel for the duration of the surgery, ... | 2011 | 22124422 |
| a fate model of pathogenic viruses in a composting toilet based on coliphage inactivation. | a composting toilet using sawdust as a matrix has the potential to trap pathogens that might occasionally be contained in human feces. therefore, care should be taken when handling the sawdust. it should also be noted that pathogenic viruses tend to have stronger tolerance than pathogenic bacteria. the fates of several species of coliphages, t4, lambda, qbeta and ms2, in sawdust were investigated as a viral model. the fates of coliphages were significantly different among them, and they changed ... | 2011 | 22125914 |
| quality of life in breast cancer survivors: 2 years post self-management intervention. | introduction: today, cancer survivors have an added new role to self manage living with the medical, emotional and role tasks that can affect their quality of life (qol). the purpose of the study was to evaluate the qol of women two years after participating in a self-management intervention program. method: the clinical trial was conducted at university malaya medical centre between 2006 and 2008. the experimental group underwent a 4-week self management program, and the control group underwent ... | 2011 | 22126488 |
| diagnostic and prognostic significance of prostate specific antigen and serum interleukin 18 and 10 in patients with locally advanced prostate cancer: a prospective study. | background: prostate cancer is one of the most common cancers afflicting men today. prostate biopsy, an invasive procedure is generally used for diagnoses but attempts are being made to find accurate and precise non- invasive biomarkers. diagnostic accuracy of prostate specific antigen (psa) has been well documented. serum interleukin-18 (il-18) and interleukin-10 (il-10) have shown their diagnostic ability in other cancers but not investigated well in prostate cancer. this study, thus determine ... | 2011 | 22126577 |
| recommendations and expert opinion on the treatment of locally advanced rectal cancer in spain. | in spain 22,000 new cases of colorectal cancer are diagnosed each year, with 13,075 deaths resulting from this disease. around 70% of colorectal cancers are localised in the colon and 30% in the rectum. a group of spanish experts established recommendations on what would be the best strategy in the treatment of locally advanced rectal cancer (larc). adequate assessment of local tumour extension, including high-resolution magnetic resonance imaging and endorectal ultrasound, is essential for succ ... | 2011 | 22126729 |
| regulation of adiponectin gene expression in adipose tissue by thyroid hormones. | available experimental data suggest that adiponectin and thyroid hormones have biological interaction in vivo. however, the effects of thyroid hormones on adipose adiponectin gene expression in thyroid dysfunction are unclear. we induced hyper- (hyper) and hypothyroidism (hypo) by daily administration of a 12 mg/l of levothyroxine and 250 mg/l of methimazole in drinking water of rats, respectively, for 42 days. the white adipose tissues and serum sample were taken on days 15, 28, 42 and also 2 w ... | 2011 | 22127636 |
| Thyroid function in childhood obesity and metabolic comorbidity. | Childhood obesity is a worldwide health problem and its prevalence is increasing steadily and dramatically all over the world. Obese subjects have a much greater likelihood than normal-weight children of acquiring dyslipidemia, elevated blood pressure, and impaired glucose metabolism, which significantly increase their risk of cardiovascular and metabolic diseases. Elevated TSH concentrations in association with normal or slightly elevated free T4 and/or free T3 levels have been consistently fou ... | 2012 | 22130312 |
| Complete Genome Sequence of the Giant Virus OBP and Comparitive Genome Analysis of the Diverse {varphi}KZ-Related Phages. | The 283,757 bp dsDNA genome of Pseudomonas fluorescens phage OBP shares a general genomic organization with Pseudomonas aeruginosa phage EL. Comparison of this genomic organization assembled in syntenic genomic blocks interspersed with hyperplastic regions of the ?KZ-related phages, supports the proposed division in the "EL-like viruses", and the "phiKZ-like viruses" within a larger subfamily. Identification of putative early transcription promoters scattered throughout the hyperplastic regions, ... | 2011 | 22130535 |
| Assembling linear DNA templates for in vitro transcription and translation. | Cell-free expression systems provide straightforward access from genes to the corresponding proteins, involving fewer handling steps than in vivo procedures. A quick procedure to assemble a gene of interest into a linear DNA template together with 3'- and 5'-untranslated regions using a coupled uracil-excision-ligation strategy based on USER Enzyme and T4 DNA ligase. This methodology will be useful for repeated cycles of expression and in vitro selection, in which gene libraries are repeatedly a ... | 2012 | 22130984 |
| immediate effects of a thoracic spine thrust manipulation on the autonomic nervous system: a randomized clinical trial. | thoracic spine manipulation has been shown to be effective for the management of neck pain. the purpose of this study was to investigate the immediate effect of a t3-t4 spinal thrust manipulation on autonomic nervous system activity in subjects with chronic cervical pain. an additional aim was to determine if the manipulation resulted in an immediate pain relief in patients with chronic neck pain when compared to a placebo intervention. one hundred subjects with chronic neck pain were randomly a ... | 2010 | 22131791 |
| hypothyroidism presenting with recurrent pericardial tamponade. | we present a case of pericardial tamponade caused by hypothyroidism. a 66-year-old man presented with acute chest pain radiating to the back. computed tomography ruled out an aortic dissection but revealed a large pericardial effusion, which was confirmed on transthoracic echocardiography showing features of tamponade. the effusion was drained and subsequent thyroid function tests showed profound hypothyroidism. no other cause of the pericardial effusion could be identified. despite the prompt i ... | 2009 | 22132022 |
| maternal thyroid function during the second half of pregnancy and child neurodevelopment at 6, 12, 24, and 60 months of age. | although evidence suggests that maternal hypothyroidism and mild hypothyroxinemia during the first half of pregnancy alters fetal neurodevelopment among euthyroid offspring, little data are available from later in gestation. in this study, we measured free t4 using direct equilibrium dialysis, as well as total t4 and tsh in 287 pregnant women at 27 weeks' gestation. we also assessed cognition, memory, language, motor functioning, and behavior in their children at 6, 12, 24, and 60 months of age. ... | 2011 | 22132346 |
| contribution of bacterial outer membrane vesicles to innate bacterial defense. | abstract: | 2011 | 22133164 |
| snd2, a nac transcription factor gene, regulates genes involved in secondary cell wall development in arabidopsis fibres and increases fibre cell area in eucalyptus. | abstract: background: nac domain transcription factors initiate secondary cell wall biosynthesis in arabidopsis fibres and vessels by activating numerous transcriptional regulators and biosynthetic genes. nac family member snd2 is an indirect target of a principal regulator of fibre secondary cell wall formation, snd1. a previous study showed that overexpression of snd2 produced a fibre cell-specific increase in secondary cell wall thickness in arabidopsis stems, and that the protein was able t ... | 2011 | 22133261 |
| the expression of the hypoxia markers ca9 and cxcr4 is correlated with survival in patients with neuroendocrine tumours of the ileum. | background/aim: the hypoxia-inducible factor pathway regulates the expression of a diverse group of molecules such as ca9 and cxcr4. our aim was to investigate the expression of these markers in a series of patients with an ileal neuroendocrine tumour (iet) at various stages of tumorigenesis. methods: the immunohistochemical expression of ca9 and cxcr4 was examined in 51 patients with a resected iet. a 'hypoxic score' was calculated, integrating the expression of both ca9 and cxcr4 (hypoxic scor ... | 2011 | 22133596 |
| Expression of programmed cell death protein 4 (PDCD4) and miR-21 in urothelial carcinoma. | BACKGROUND: We investigated the role of the programmed cell death 4 (PDCD4) tumor suppressor gene in specimens of transitional cell carcinoma and of healthy individuals. METHODS: PDCD4 immunohistochemical expression was investigated in 294 cases in histologically proven transitional cell carcinoma in different tumorous stages (28 controls, 122 non-muscle invasive urothelial carcinoma, stages Tis-T1, 119 invasive transitional cell carcinoma stages T2-T4 and 25 metastases). MiR-21 expression, an i ... | 2011 | 22133680 |
| suppression of ns3 and mp is important for the stable inheritance of rnai-mediated rice stripe virus (rsv) resistance obtained by targeting the fully complementary rsv-cp gene. | rice stripe virus (rsv) is a viral disease that seriously impacts rice production in east asia, most notably in korea, china, and japan. highly rsv-resistant transgenic japonica rice plants were generated using a dsrnai construct designed to silence the entire sequence region of the rsv-cp gene. transgenic rice plants were inoculated with a population of viruliferous insects, small brown planthoppers (sbph), and their resistance was evaluated using elisa and an infection rate assay. a correlatio ... | 2011 | 22134721 |
| Sacropelvic Fixation With Iliosacral Screws: Applications and Results in Adult Spinal Deformities. | STUDY DESIGN:: Retrospective radiographic and clinical review. OBJECTIVE:: To determine the feasibility of iliosacral screw fixation in adult spinal deformations. SUMMARY OF BACKGROUND DATA:: Pelvic fixation is one of the most challenging instrumentation problems. The poor bone quality frequently found within the sacrum and the large lumbosacral loads with cantilever pullout forces across this region explain its frequent failure. METHODS:: Fourteen adult patients undergoing pelvic fixation using ... | 2011 | 22134734 |
| Long-Term Outcomes Following Vocational Rehabilitation Treatments in Patients with Prolonged Fatigue. | BACKGROUND: Multi-component vocational rehabilitation (VR) provides positive short-term outcomes in patients with prolonged fatigue. PURPOSE: The purpose of this study is to evaluate the long-term outcomes of Dutch multi-component VR up to 18 months after treatment. METHOD: In a pre-post-study, measurements were taken before treatment (t0), after treat ... | 2011 | 22135188 |
| crystal structure of the bacteriophage t4 late-transcription coactivator gp33 with the β-subunit flap domain of escherichia coli rna polymerase. | activated transcription of the bacteriophage t4 late genes, which is coupled to concurrent dna replication, is accomplished by an initiation complex containing the host rna polymerase associated with two phage-encoded proteins, gp55 (the basal promoter specificity factor) and gp33 (the coactivator), as well as the dna-mounted sliding-clamp processivity factor of the phage t4 replisome (gp45, the activator). we have determined the 3.0 å-resolution x-ray crystal structure of gp33 complexed with it ... | 2011 | 22135460 |
| ct thoracic duct lymphography in cats by popliteal lymph node iohexol injection. | three different doses (1.0, 1.5, and 2.0 ml) of iohexol (300 mgi/ml) were injected percutaneously into the popliteal lymph node of eight adult cats under ultrasound guidance. serial transverse ct images of five regions of interest (l3, t13, t8, t4, and t1 level) were performed at 2-min intervals, and the attenuation in hounsfield units (hu) of the lymphatic vessels was measured for determination of the optimal dose of iohexol and ct scan parameters. the optimal dose was 1.5 ml and helical ct acq ... | 2011 | 22136199 |
| Early Markers of Tubular Dysfunction in Antiretroviral-Experienced HIV-Infected Patients Treated with Tenofovir Versus Abacavir. | Abstract Tenofovir disoproxil fumerate (TDF) is an effective nucleoside reverse transcriptase inhibitor for HIV infection but it is potentially nephrotoxic. A selective mithochondrial toxicity has been hypothesized. To assess early markers of renal toxicity, we evaluated a cohort of antiretroviral (ARV)-experienced HIV patients who had been switched from a thymidinic backbone to either a TDF/emtricitabine regimen (TDF; 73 patients) or an abacavir/lamivudine (ABV) regimen (28 patients). Markers ... | 2012 | 22136504 |
| guillain-barre syndrome presenting with sensory disturbance following a herpes virus infection: a case report. | abstract: introduction: we present a case of an unusual clinical manifestation of guillain-barre syndrome following a pre-existing herpes virus infection. although there have been several reports describing the co-existence of herpes virus infection and guillain-barre syndrome, we undertook a more in-depth study of the cross-reactivity between herpes viruses and recommend a follow-up study based on serology tests. case presentation: a 39-year-old healthy caucasian man with guillain-barre syndro ... | 2011 | 22136568 |
| Functional and sensitive outcomes after tongue reconstruction: About a series of 30 patients. | Few studies reported both functional and sensitive long-term evaluations after tongue reconstruction. The aim of this study was to assess functional outcomes and sensitive recovery after tongue reconstruction with fasciocutaneous free flap (FCFF) or musculocutaneous pedicled flap (MCPF) without nerve anastomosis. We enrolled 30 patients having no recurrence from a consecutive series of 79 tongue reconstructions as part of a cancer treatment. All patients were submitted to functional and sensitiv ... | 2011 | 22137578 |
| Guideline for prophylactic feeding tube insertion in patients undergoing resection of head and neck cancers. | BACKGROUND: Supplementary nutrition is an important aspect of the multidisciplinary management of head and neck cancer patients. In our unit, method of feeding is based on an arbitrary predicted duration of overall treatment (<30 days indicates NG feeding, >30 days prophylactic PEG tube insertion is appropriate). This paper provides a guideline to assist in choosing the feeding method early on to avoid the need for later PEG insertion in those who were initially fed orally or via NG tube. PATIEN ... | 2011 | 22137826 |
| adaptive radiotherapy for head-and-neck cancer: initial clinical outcomes from a prospective trial. | purpose: to present pilot toxicity and survival outcomes for a prospective trial investigating adaptive radiotherapy (art) for oropharyngeal squamous cell carcinoma. methods and materials: a total of 24 patients were enrolled in an institutional review board-approved clinical trial; data for 22 of these patients were analyzed. daily ct-guided setup and deformable image registration permitted serial mapping of clinical target volumes and avoidance structures for art planning. primary site was bas ... | 2011 | 22138459 |
| A meta-analysis of D1 versus D2 lymph node dissection. | BACKGROUND: Surgery is the only curative treatment for patients with gastric cancer. However, the extent of lymph node dissection is still debated. Therefore, with the publication of newer trial results, we conducted an updated meta-analysis of D1 versus D2 randomized controlled trials comparing outcomes. METHODS: Systematic searches were conducted using Medline, Embase, and the Cochrane Central Register of Contr ... | 2011 | 22138927 |
| Tripchlorolide induces cell death in lung cancer cells by autophagy. | It has been demonstrated that triptolide inhibits the growth of several types of cancer cells in vitro and prevents tumor growth in vivo by inducing apoptosis and autophagy. Here we showed that Tripchlorolide (T4) significantly suppressed the proliferation of A549 cells in a dose- and time-dependent manner. This suppressive effect was diminished when cells were pretreated with 3-Methylamphetamine (3-MA). After the cells were treated wit ... | 2011 | 22139090 |
| molecular determinants of hiv-2 r5-x4 tropism in the v3 loop: development of a new genotypic tool. | objective. the use of ccr5 inhibitors requires a tool to predict human immunodeficiency virus type 2 (hiv-2) tropism, as established in hiv-1. the aim of our study was to identify genotypic determinants of hiv-2 tropism located in the gp105 v3 loop. methods. hiv-2 tropism phenotypic assays were performed on 53 hiv-2 clinical isolates using gfp expressing human osteosarcoma t4 [ghost(3)] cell lines expressing cd4 and ccr5 or cxcr4 coreceptors. the gp105 v3 loop was sequenced and analyzed. results ... | 2012 | 22140264 |
| Multi-Institutional Analysis of Robotic Radical Cystectomy for Bladder Cancer: Perioperative Outcomes and Complications in 227 Patients. | Abstract Purpose: Recently, some surgeons have begun to describe single-institution case series with less invasive surgical approaches to bladder cancer such as laparoscopic or robotic-assisted techniques. We report on a multi-institutional, multi-surgeon experience with robotic radical cystectomy with regard to operative and pathologic outcomes and complications to evaluate the feasibility and reproducibility of this technique in a large cohort of patients. Subjects and Methods: Two hundred ... | 2011 | 22142028 |
| Thyroid status two decades after salt iodisation: Country-wide data in school children from India. | Objective: Country-wide evaluation of thyroid disorders in school children following two decades of universal salt iodisation (USI) has not been carried out till date.The present study was planned with aim to assess thyroid status of school children two decades after launch of USI program. Design: Population survey Patients: We collected data from 25 schools in 19 cities across five different geographical zones of India. Those childrenwho were evaluated for anthropometry, goitre status by p ... | 2011 | 22142266 |
| differentiated thyroid carcinomas in childhood: clinicopathologic results of 26 patients. | epithelial solid tumors which are rare in childhood are responsible for about 9% of all childhood cancers. however, differentiated thyroid carcinomas (dtcs) are the most common of the endocrine neoplasia (0.5%-3%) in all childhood malignancies. pediatric thyroid cancers have some clinicopathological differences from adult thyroid cancers. this analysis investigates the clinical behavior and pathological characteristics of childhood thyroid cancers, with treatment options and outcomes. a total of ... | 2011 | 22145466 |
| analysis of the seventh edition of american joint committee on colon cancer staging. | purpose: the seventh edition of the american joint committee on cancer (ajcc) staging system has new substages for colon cancer. we used survival data from a single medical center to analyze this new ajcc edition. methods: the colon cancer database of taipei veterans general hospital provided 1,865 patient records covering from 1999 to 2005. survival rates were evaluated using the kaplan-meier method. ... | 2011 | 22146786 |
| impact of subclinical hypothyroidism treatment in systolic and diastolic cardiac function. | to evaluate the effects of levothyroxine (l-t4) replacement in echocardiographic parameters of middle-aged women with subclinical hypothyroidism (sh). | 2011 | 22147094 |
| locally advanced colorectal cancer: results of surgical treatment and prognostic factors. | to evaluate the incidence surgical results and prognostic factors of locally advanced colorectal cancer. | 2011 | 22147133 |
| (32)P-postlabelling for the Sensitive Detection of DNA Adducts. | 32P-postlabelling is a technique originally described by Kurt Randerath and colleagues for the sensitive detection of damage produced in DNA by reactive chemicals or genotoxins. The procedure essentially entails the enzymatic digestion of DNA to nucleoside 3'-monophosphates which are then radioactively labelled using T4 polynucleotide kinase and [?(32)P]-adenosine triphosphate. Adducted nucleoside-3'-5'-bisphosphates are then separated from their normal counterparts by thin layer chromatography. ... | 2012 | 22147574 |
| The effect of the intravenous phenylephrine on the level of spinal anesthesia. | Spinal anesthesia causes hypotension and bradycardia due to sympathetic nerve block and it is difficult to predict the level of sensory block and the duration of blockade. Recent studies have reported that intravenous phenylephrine can reduce the rostral spread of spinal anesthesia in pregnant women. We think a phenylephrine infusion will be useful for maintaining the baseline blood pressure by reducing the rostral spread of spinal anesthesia during the elective surgery of non-obstetric patients ... | 2011 | 22148084 |
| the effect of nitroglycerin on hemodynamic changes during laparoscopic low anterior resection. | more laparoscopic low anterior resections (lar) are being performed in recent years. there has been controversy around the hemodynamic changes affected by the trendelenburg position and pneumoperitoneum during lar. the goal of this study was to analyze the effect of nitroglycerin (ntg) on hemodynamic changes during lar. | 2011 | 22148087 |
| adsorption of viruses on activated carbon. equilibriums and kinetics of the attachment of escherichia coli bacteriophage t4 on activated carbon. | 1967 | 22148337 | |
| propylthiouracil-induced interstitial pneumonia in a caucasian women with amiodarone induced thyrotoxicosis. | background. propylthiouracil (ptu) therapy is associated with a variety of adverse reactions, among the most rare being interstitial pneumonia. to date, this has been reported in four asian patients with autoimmune hyperthyroidism. here we describe a caucasian woman who developed a bronchiolitis obliterans organizing pneumonia (boop)-like interstitial pneumonia after ptu administration for amiodarone-induced thyrotoxicosis. patient findings. the patient was a 68 year old women who had been tre ... | 2011 | 22150593 |