Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| preoperative nt-probnp levels: a reliable parameter to estimate postoperative atrial fibrillation in coronary artery bypass patients. | atrial fibrillation (af) is one of the most common complications after coronary artery bypass grafting (cabg). this study was designed to evaluate whether the levels of preoperative and postoperative n-terminal pro-brain natriuretic peptide (nt-probnp) are predictors of postoperative paroxysmal atrial fibrillation in patients who undergo coronary artery bypass surgery. | 2011 | 21394710 |
| [dependence of lipid peroxidation changes and antioxidant activity in myocardium under acute and chronic stress from organism thyroid status]. | in experiments on 122 unbreed white male rats with body weight 250-300 g investigated influence of thyroid status on evoked by chronic stress (cs--immobilization on 3 h during 5 days) and acute stress (as--once immobilization during 3 h) changes of lipid peroxidation (lp) intensivity and antioxidant activity (aoa) in myocardium. it was shown that chronic stress, which decreases triiodothyronine and thyroxine levels in blood, leads to more market lp activation and lowering of superoxiddismutase a ... | 2010 | 21395115 |
| [resistant hypercholesteremia in clinical practice: new insight into the causes and methods of treatment]. | coronary heart disease and other diseases caused by atherosclerosis, take first place among the causes of adult mortality. leading role in the development of atherosclerosis belongs to violations of cholesterol metabolism. reducing mortality from ischemic heart disease primarily associated with adequate correction of the lipid metabolism. the research of the possible causes and correction of resistant hypercholesterolemia is done. determined that some patients with resistant to statins hyperchol ... | 2010 | 21395156 |
| expression profile of cancer-testis genes in transitional cell carcinoma of the bladder. | objectives:: to explore the expression profile of multiple cancer testis (ct) genes in transitional cell carcinoma of bladder (tcc), and investigate its possible correlation with clinicopathologic characteristics. methods:: the mrna expression of 6 ct genes was detected using reverse transcription polymerase chain reaction (rt-pcr) for 102 tcc samples (59 ta-t1, 43 t2-t4, 44 g1, 32 g2, and 26 g3 samples) as well as the matching adjacent normal bladder mucosa for each sample. the mage-a3 protein ... | 2011 | 21396841 |
| presence and regulation of d1 and d2 deiodinases in rat white adipose tissue. | thyroid hormones regulate adipogenic differentiation, lipogenic and lipolytic metabolism, and mitochondrial activity in adipose tissue. triiodothyronine (t3) levels in tissues are regulated by the deiodinase enzymes. the objective was to study the activity and messenger rna (mrna) expression of the 5' outer-ring deiodinases (type 1 [d1] and type 2 [d2] deiodinase) and thyroid hormone concentrations in rat white adipose tissue (wat), where only d1 activity had been described. control, thyroidecto ... | 2011 | 21397282 |
| effects of modified haizao yuhu decoction in experimental autoimmune thyroiditis rats. | modified haizao yuhu decoction (mhyd), based on clinical experience, has been used for approximately 500 years and famous for its efficiency in treating thyroid-related diseases. | 2011 | 21397681 |
| clinicopathological significance of carbonic anhydrase 9, glucose transporter-1, ki-67 and p53 expression in oral squamous cell carcinoma. | carbonic anhydrase 9 (ca9) is a glycoprotein present on the surface of cell membranes. it is expressed in 90% of renal cancer cells, but not in normal kidney tissue. immunotherapy targeting ca9 is underway, and our group has also conducted a clinical trial using ca9 as a cancer vaccine and confirmed the induction of cytotoxic t lymphocytes, with efficacy in some cases. expression of ca9 antigen in oral cancer has not been reported in japan, but our results indicate that immunotherapy targeting c ... | 2011 | 21399882 |
| trimerization of murine tnf ligand family member light increases the cytotoxic activity against the fm3a mammary carcinoma cell line. | light is a member of the tumor necrosis factor ligand superfamily, which plays important roles in inflammatory and immune responses. light forms a membrane-anchored homotrimeric complex on the cell surface and is often processed as a soluble protein. recombinant soluble human light produced by mammalian cells or escherichia coli is functional at nanomolar concentrations. however, there is little information about the biological activity of mouse light (mlight) because of the difficulty in produc ... | 2011 | 21400099 |
| resection and free tissue reconstruction of locally advanced oral cancer: avoidance of lip split. | the purpose of this study is to report the outcomes of patients with locally advanced (t3-t4) oral cancers undergoing surgical resection and free tissue reconstruction without the lower lip-split procedure. in this retrospective chart review, we analyzed 86 consecutive patients presenting between july 2000 and december 2009 at our university-based, tertiary care medical center. the oral site distribution was: 73 (86%) oral cavity, 10 (12%) oropharynx, and 3 (2%) combined. the average specimen vo ... | 2011 | 21400582 |
| liposomes containing glucosyl ceramide specifically bind t4 bacteriophage: a self-assembling nanocarrier formulation. | a unique formulation is described comprising liposomes containing glucosyl ceramide (glucer) in the lipid bilayer to which bacteriophage t4 was attached. binding of the phage t4 did not occur to glycolipids, such as galactosyl ceramide, containing an aldose in which the c-2 or c-4 conformations were not identical to glucose. these results strongly support previous proposals that glucose is a major receptor moiety for t4 binding to escherichia coli. by using the binding of t4 to liposomal glucer, ... | 2011 | 21401373 |
| effect of thyroid hormone replacement therapy on ovarian volume and androgen hormones in patients with untreated primary hypothyroidism. | primary hypothyroidism may be associated with ovarian enlargement and/ or cyst formation. we evaluated the effect of thyroid hormone replacement therapy on hormonal changes, ovarian volume and sonographic appearance. | 2011 | 21403408 |
| anal canal carcinoma treatment results: the experience of a single institution. | prior to the mid-1980s, the treatment of choice for anal cancer was abdominoperineal resection. currently, combined chemoradiation is the standard of care. or objective was to analyze results of treatment for anal canal carcinoma treated with combined chemoradiation. | 2011 | 21403412 |
| cotrel-dubousset instrumentation in neuromuscular scoliosis. | the study design is retrospective. the aim is to describe our experience about the treatment of patients with neuromuscular scoliosis (nms) using cotrel-dubousset instrumentation. neuromuscular scoliosis are difficult deformities to treat. a careful assessment and an understanding of the primary disease and its prognosis are essential for planning treatment which is aimed at maximizing function. these patients may have pelvic obliquity, dislocation of the hip, limited balance or ability to sit, ... | 2011 | 21404030 |
| revealing time bunching effect in single-molecule enzyme conformational dynamics. | in this perspective, we focus our discussion on how the single-molecule spectroscopy and statistical analysis are able to reveal enzyme hidden properties, taking the study of t4 lysozyme as an example. protein conformational fluctuations and dynamics play a crucial role in biomolecular functions, such as in enzymatic reactions. single-molecule spectroscopy is a powerful approach to analyze protein conformational dynamics under physiological conditions, providing dynamic perspectives on a molecul ... | 2011 | 21409227 |
| h2o2 scavenging inhibits g1/s transition by increasing nuclear levels of p27kip1. | the aim of the present study was to evaluate cell cycle regulation by scavenging h(2)o(2) in tumor cells. a significant arrest in the g1 phase of the cell cycle was demonstrated in ch72-t4 carcinoma cells exposed to catalase, associated with a decrease in cyclin d1 and an increase in the cdk inhibitory protein p27(kip1). moreover, we found a differential intracellular distribution of p27(kip1), which remained in the nucleus after catalase treatment. in vivo experiments showed an increase in nucl ... | 2011 | 21411221 |
| longitudinal evaluation of a smoking prevention program for adolescents. | to evaluate a smoking prevention program for adolescents. | 2011 | 21412573 |
| [myocardial infarction and shock associated with thyrotoxicosis]. | a thyroid storm--a sudden, life-threatening exacerbation of thyrotoxicosis--can lead to multiple organ failure due to hyperactivity of the sympathetic nervous system. symptoms may include fever, tachycardia, cardiovascular collapse, myocardial infarction, hepatic failure, cerebral infarction, delirium, coma, and rhabdomyolysis. various therapies have been proposed for the management of thyrotoxicosis. they include: reduction of sympathetic outflow (beta-blockers); decreased production and releas ... | 2010 | 21413419 |
| severe progressive scoliosis due to huge subcutaneous cavernous hemangioma: a case report. | cavernous hemangioma consists mainly of congenital vascular malformations present before birth and gradually increasing in size with skeletal growth. a small number of patients with cavernous hemangioma develop scoliosis, and surgical treatment for the scoliosis in such cases has not been reported to date. here we report a 12-year-old male patient with severe progressive scoliosis due to a huge subcutaneous cavernous hemangioma, who underwent posterior correction and fusion surgery. upon referra ... | 2011 | 21414205 |
| perinatal tcdd exposure alters developmental neuroendocrine system. | this study tested whether maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) may disrupt the development of neuroendocrine system of their offspring during the perinatal period. tcdd (0.2 or 0.4 µg/kg body weight) was orally administered to pregnant rats from gestation day (gd) 1 to lactation day (ld) 30. potential effects on neuroendocrine function were evaluated by measuring serum thyroid hormone levels in pregnant rats and their offspring and measuring some biochemical parameters ... | 2011 | 21414370 |
| anal cancer: an examination of radiotherapy strategies. | the radiation therapy oncology group 9811, accord-03, and act ii phase iii trials in anal cancer showed no benefit for cisplatin-based induction and maintenance chemotherapy, or radiation dose-escalation >59 gy. this review examines the efficacy and toxicity of chemoradiation (crt) in anal cancer, and discusses potential alternative radiotherapy strategies. the evidence for the review was compiled from randomized and nonrandomized trials of radiation therapy and crt. a total of 103 retrospective ... | 2011 | 21414513 |
| impaired pharmacokinetics of levothyroxine in severely obese volunteers. | suppressive or replacement doses of levothyroxine (lt4) are affected by the rate and extent of the active ingredient absorbed, as well as by the lean body mass. obesity has reached epidemic proportions worldwide and is related with many comorbidities. the aim of this study was to determine the pharmacokinetic parameters of lt4 in severely obese individuals and compared them with similar data in lean control subjects. | 2011 | 21417917 |
| [influence of c-kit rna interference mediated by admax adenovirus upon gastrointestinal stromal tumor in nude mice]. | to investigate a novel therapeutic regiment for gastrointestinal stromal tumor (gist) based on c-kit rna interference (rnai) under the mediation of admax adenovirus. | 2011 | 21418861 |
| the collateral network concept: remodeling of the arterial collateral network after experimental segmental artery sacrifice. | a comprehensive strategy to prevent paraplegia after open surgical or endovascular repair of thoracoabdominal aortic aneurysms requires a thorough understanding of the response of the collateral network to extensive segmental artery sacrifice. | 2011 | 21419904 |
| [abnormal uptake of l-131 in the lung in a patient with thyroid cancer: is it metastasis or not?]. | a 66-year old woman with a background of cystic bronchiectasis in the right lung in her childhood was referred to endocrinology for a study of multinodular goiter. the patient did not report any personal or family backgrounds of thyroid cancer. the analysis showed the following hormone levels: free t4 1.14 µg/dl (ln: 0.9-1.7) and tsh 2.45 µu/ml (ln 0.3-4.5). the ultrasound showed several left thyroid lobe nodes smaller than 1cm, hypoechogenic and well-defined and a larger one in the right thyroi ... | 2011 | 21420668 |
| colorectal cancer in the young: trends, characteristics and outcome. | colorectal cancer (crc) in young patients is associated with a poor outcome due to advanced stage at diagnosis and poor differentiation. | 2011 | 21424713 |
| serum tsh reference interval in healthy finnish adults using the abbott architect 2000i analyzer. | current serum tsh reference intervals have been criticized as they were established from unselected background populations. a special concern is that the upper limit, which defines subclinical hypothyroidism, is too high. the objective was to redefine the tsh reference interval in the adult finnish population. the current reference interval for the widely used abbott architect method in finland is 0.4-4.0 mu/l. | 2011 | 21426266 |
| physiological role and regulation of iodothyronine deiodinases: a 2011 update. | t4 is a prohormone secreted by the thyroid. t4 has a long half life in circulation and it is tightly regulated to remain constant in a variety of circumstances. however, the availability of iodothyronine selenodeiodinases allow both the initiation or the cessation of thyroid hormone action and can result in surprisingly acute changes in the intracellular concentration of the active hormone t3, in a tissue- specific and chronologically-determined fashion, in spite of the constant circulating leve ... | 2011 | 21427525 |
| how to prepare a chiral grignard reagent: a theoretical proposal. | it is shown that two competitive pathways (t2 vs t4) exist for grignard reagent formation. while the nonradical pathway t2 leads to retention of the configuration, the radical pathway t4 gives racemization. our calculations suggest the way that t2 can be enhanced, which should be of significance to prompt new synthesis approaches for the preparation of chiral grignard reagents. | 2011 | 21428284 |
| evaluation of ventricular functions using tissue doppler echocardiography in patients with subclinical hypothyroidism. | we evaluated right (rv) and left (lv) ventricle functions by tissue doppler imaging (tdi) in patients with subclinical hypothyroidism (sh). | 2011 | 21430418 |
| cervicothoracic spinal epidural hematoma after anterior cervical spinal surgery. | the purpose of this case report is to describe a rare case of a cervicothoracic spinal epidural hematoma (seh) after anterior cervical spine surgery. a 60-year-old man complained of severe neck and arm pain 4 hours after anterior cervical discectomy and fusion at the c5-6 level. magnetic resonance imaging revealed a postoperative seh extending from c1 to t4. direct hemostasis and drainage of loculated hematoma at the c5-6 level completely improved the patient's condition. when a patient complain ... | 2010 | 21430984 |
| neurologic complication following spinal epidural anesthesia in a patient with spinal intradural extramedullary tumor. | paraplegia following spinal epidural anesthesia is extremely rare. various lesions for neurologic complications have been documented in the literature. we report a 66-year-old female who developed paraplegia after left knee surgery for osteoarthritis under spinal epidural anesthesia. in the recovery room, paraplegia and numbness below t4 vertebra was checked. a magnetic resonance image (mri) scan showed a spinal thoracic intradural extramedullary (idem) tumor. after extirpation of the tumor, the ... | 2010 | 21430985 |
| noninvasive investigation of asymmetrically conjoined tripus twins with features of rachipagus, parapagus dicephalus, and cephalopagus. | a hypothetical mechanism for conjoined twinning postulated by spencer ([2003] developmental malformations and clinical implications, baltimore: johns hopkins university press, p 1-476) suggests that, after separation, monovular twins fuse in one of eight predictable homologous sites. the tripus fetal specimen under study embodies characteristics of three types therefore preventing it from classification into a simple variant of any one of the eight twin types described by spencer. the aim of thi ... | 2011 | 21433086 |
| oxidative profile in patients with colon cancer: effects of ruta chalepensis l. | to verify the involvement of free radicals in tumor progression and to investigate the effects of an ethanolic extract of ruta chalepensis l. and of rutin in blood of patients with colon cancer. | 2011 | 21434485 |
| the role of helicobacter pylori in patients with hypothyroidism in whom could not be achieved normal thyrotropin levels despite treatment with high doses of thyroxine. | ôçéhelicobacter pylori infection is a most frequent cause of chronic gastritis. h. pylori may decrease absorption of oral thyroxine by decreasing gastric acid secretion in the stomach. in this study, we aimed to investigate the change in thyroid function tests of the cases after h. pylori eradication who were not responding to high doses of thyroxine treatment before h. pylori eradication. | 2011 | 21435090 |
| prosthetic rehabilitation, implant survival and quality of life 2 to 5 years after resection of oral tumors. | background: after oral tumor resection, structural and functional rehabilitation by means of dental prostheses is complex, and positive treatment outcome is not always predictable. purpose: the objective of the study was to report on oral rehabilitation and quality of life 2-5 years after resection of malignant oral tumors. materials and methods: data of 46 patients (57ôçâ-¦ôçâ7 years) who underwent oral tumor surgery were available. more than 50% of tumors were classified t3 or t4. open oro-nas ... | 2011 | 21435159 |
| spinal angiolipoma in a pregnant woman presenting with acute epidural hemorrhage. | a 26-year-old woman in week 31 of pregnancy presented to the emergency room with acute onset of paraplegia. her medical history was unremarkable. neurological examination revealed complete paraplegia, total sensory loss below the t7 dermatome, and significant vesicorectal dysfunction. mri revealed an intraspinal mass from t3 to t4, which was hyperintense on both t1-weighted and t2-weighted images. blood examination found no abnormality. she underwent emergent hemilaminectomy and removal of the h ... | 2011 | 21435880 |
| triclosan and thyroid-mediated metamorphosis in anurans: differentiating growth effects from thyroid-driven metamorphosis in xenopus laevis. | in a previously reported study, we used a standard metamorphosis anuran model to assess potential effect of the antibacterial agent triclosan (tcs) on normal prometamorphic xenopus laevis. results indicated that environmentally relevant tcs concentrations did not alter the normal course of thyroid-mediated metamorphosis in this standard anuran model. however, to examine potential effects of tcs exposure during premetamorphosis and to distinguish between effects on metamorphosis and effects on gr ... | 2011 | 21436124 |
| survival outcomes in surgical treatment of 72 cases of squamous cell carcinoma of the temporal bone. | to evaluate surgical outcomes for squamous cell carcinoma of the temporal bone. | 2011 | 21436754 |
| single virus genomics: a new tool for virus discovery. | whole genome amplification and sequencing of single microbial cells has significantly influenced genomics and microbial ecology by facilitating direct recovery of reference genome data. however, viral genomics continues to suffer due to difficulties related to the isolation and characterization of uncultivated viruses. we report here on a new approach called 'single virus genomics', which enabled the isolation and complete genome sequencing of the first single virus particle. a mixed assemblage ... | 2011 | 21436882 |
| adenocarcinoma of the esophagogastric junction: neoadjuvant radiochemotherapy and radical surgery : early results and toxicity. | to retrospectively evaluate treatment results and toxicity following a combined approach consisting of neoadjuvant radiochemotherapy and radical surgery in advanced adenocarcinoma of the esophagus and gastroesophageal junction. | 2011 | 21437768 |
| the prognostic and staging implications of bone invasion in oral squamous cell carcinoma. | background: a study was undertaken to determine whether bone invasion is an independent prognostic factor in oral squamous cell carcinoma (scc) after taking into account the extent of bone invasion. methods: the study was a retrospective review of 498 patients with oral scc undergoing surgery with curative intent, 102 of whom had pathologically proven bone invasion. bone invasion was categorized as absent, cortical, or medullary and tested for association with disease control and survival. resul ... | 2011 | 21437887 |
| examination of laryngoesophageal dysfunction-free survival as an endpoint in nonsurgical treatment of squamous cell carcinomas of the larynx and hypopharynx. | background: a recently published consensus guideline suggested a new endpoint for clinical trials involving cancer of the larynx and hypopharynx: laryngoesophageal dysfunction-free survival (ledfs). the authors of this report examined ledfs in the context of definitive radiotherapy alone (rt) or with concurrent chemoradiotherapy (crt). methods: patients with a stage iii to ivb squamous cell carcinomas of the larynx or hypopharynx who received definitive radiotherapy were included. consensus guid ... | 2011 | 21437891 |
| short-term neoadjuvant androgen deprivation and radiotherapy for locally advanced prostate cancer: 10-year data from the trog 96.01 randomised trial. | the trog 96.01 trial assessed whether 3-month and 6-month short-term neoadjuvant androgen deprivation therapy (nadt) decreases clinical progression and mortality after radiotherapy for locally advanced prostate cancer. here we report the 10-year results. | 2011 | 21440505 |
| clinicopathologic features and determinants of gleason score of prostate cancer in ghanaian men. | objective: prostate cancer is reported to be more aggressive in blacks. we studied the clinicopathologic features of prostate cancer in ghana, in order to determine the factors responsible for them and to find out if there is any relationship between them. method: patients referred with a biopsy proven diagnosis of carcinoma of the prostate to the cancer center of korle bu teaching hospital, accra, ghana, from 2003 to 2007 were studied. information with respect to age at diagnosis, presenting sy ... | 2011 | 21441045 |
| purification, biochemical characterization, and bioactive properties of a lectin purified from the seeds of white tepary bean (phaseolus acutifolius variety latifolius). | the present work shows the characterization of phaseolus acutifolius variety latifolius, on which little research has been published, and provides detailed information on the corresponding lectin. this protein was purified from a semi-domesticated line of white tepary beans from sonora, mexico, by precipitation of the aqueous extract with ammonium sulfate, followed by affinity chromatography on an immobilized fetuin matrix. maldi tof analysis of phaseolus acutifolius agglutinin (paa) showed that ... | 2011 | 21441861 |
| preservation of the nasolacrimal duct during endoscopic medial maxillectomy for sinonasal inverted papilloma. | background: to assess the efficacy of a new endonasal medial maxillectomy technique (emm) for the treatment of inverted papilloma (ip). methodolog: a prospective series of 55 consecutive patients diagnosed with ip between march 2002 and april 2009 were entered into this study. the new surgical technique was applied to tumors arising from the anterior part of the maxillary sinus. after conventional emm, the entire nasolacrimal duct was separated from the bony component of the nasolacrimal canal a ... | 2010 | 21442084 |
| acute t3 treatment protects the heart against ischemia-reperfusion injury via tra1 receptor. | we have previously shown that acute thyroid hormone treatment could limit reperfusion injury and increase post-ischemic recovery of function. in the present study, we further explore potential initiating mechanisms of this response. thus, isolated rat hearts were subjected to 30 min zero-flow global ischemia (i) followed by 60-min reperfusion (r). reperfusion injury was assessed by post-ischemic recovery of left ventricular developed pressure (lvdp%) and ldh release. t3 at a dose of 60 nm which ... | 2011 | 21442236 |
| [effect of acupuncture-assisted anesthesia on stress response during laparoscopic cholecystectomy in aged patients]. | to compare the difference between transcutaneous electrical acupoint stimulation (teas) assisted general anesthesia and simple general anesthesia on stress response during laparoscopic cholecystectomy (lc) in aged patients. | 2011 | 21442823 |
| [immunological and endocrinological pattern in adhd etiopathogenesis]. | attention-deficit hyperactivity disorder (adhd) is the most prevalent neurodevelopmental disorder among children. there are 3 subtypes of adhd: (1) with prevalent inattentive symptoms (2) with prevalent hyperactive-impulsive symptoms and (3) the combined subtype. it typically manifests itself before age 7 years and occurs more frequently in boys than in girls. it is diagnosed when the hyperactivity, impulsiveness and inattention last long, appear at least in two environments and their intensity ... | 2010 | 21442976 |
| [effects of winter cover crop on methane and nitrous oxide emission from paddy field]. | static chamber-gc technique was employed to study the effects of different treatment winter cover crops, including no-tillage and directly sowing ryegrass (t1), no-tillage and directly sowing chinese milk vetch (t2), tillage and transplanting rape (t3), no-tillage and directly sowing rape (t4), and fallowing (ck), on the ch4 and n2o emission from double cropping rice paddy field. during the growth period of test winter cover crops, the ch4 and n2o emission in treatments t1-t4 was significantly h ... | 2010 | 21443008 |
| spontaneous intracranial hypotension: efficacy of radiologic targeting vs blind blood patch. | the aim of this study was to evaluate the efficacies and compare the outcomes of targeted and blind epidural blood patch (ebp) treatments of spontaneous intracranial hypotension (sih). | 2011 | 21444899 |
| evaluation of the effect of l-thyroxin therapy on cardiac functions by using novel tissue doppler-derived indices in patients with subclinical hypothyroidism. | subclinical hypothyroidism (sh) is characterized by normal serum free t4 (ft4), free t3 (ft3) levels and increased serum thyroid stimulating hormone (tsh) levels.the aim of this study was to assess the validity of tissue doppler imaging (tdi) in evaluating cardiac effects of sh and to demonstrate the improving effects of l-thyroxin(l-t4) on tdi parameters. | 2011 | 21446380 |
| a pilot feasibility study of tnferade™ biologic with capecitabine and radiation therapy followed by surgical resection for the treatment of rectal cancer. | objective: the purpose of this pilot study was to evaluate the feasibility and tolerability of weekly intratumoral tnferade™ injections combined with concurrent capecitabine and radiotherapy in the treatment of patients with locally advanced rectal cancer. methods: patients with t3, t4, or n+ rectal cancer received radiotherapy to a total dose of 50.4-54 gy in combination with capecitabine 937.5 mg/m(2) p.o. b.i.d. tnferade™ at a dose of 4 × 10(10) particle units was injected into the rectal tum ... | 2011 | 21447969 |
| evaluation of thyroid functions with respect to iodine status and trh test in chronic autoimmune thyroiditis. | objective: chronic autoimmune thyroiditis (cat) is the most common form of thyroiditis in childhood and a frequent cause of acquired hypothyroidism. the objective of this study was to evaluate the thyroid status of childrenand adolescents with cat with respect to iodine status and diagnostic values of thyrotropin-releasing hormone (trh) test. methods: seventy-one children (mean age: 11.6 years) were studied in a retrospective analysis. free thyroxine (t4), thyrotropin (tsh), tsh response to trh ... | 2011 | 21448329 |
| thyroid hypoplasia as a cause of congenital hypothyroidism in monozygotic twins concordant for rubinstein-taybi syndrome. | rubinstein-taybi syndrome (rsts), a genetic disorder characterized by growth retardation, mental deficiency, dysmorphic face, broad thumbs and large toes, generally affects monozygotic twins concordantly. thyroid hypoplasia (th) is a common cause of congenital hypothyroidism (ch) and often accompanies dysmorphic syndromes. a pair of female twins were admitted to our neonatology unit 16 hours after delivery. they were born at 35 weeks of gestation. both twins had an unusual dysmorphic facial appe ... | 2011 | 21448332 |
| prognostic factors of t4 gastric cancer patients undergoing potentially curative resection. | to investigate the prognostic factors of t4 gastric cancer patients without distant metastasis who could undergo potentially curative resection. | 2011 | 21448423 |
| maternal flaxseed diet during lactation programs thyroid hormones metabolism and action in the male adult offspring in rats. | flaxseed has several benefits for health such as improvement in lipid profile; and since thyroid hormones increases cholesterol biliary excretion, we decide to evaluate the programming effect of maternal flaxseed diet during lactation upon thyroid hormone metabolism and action in the adult offspring in rats. at birth, lactating rats were divided into: flaxseed dams (f) - diet with 25% of flaxseed - and controls dams (c). f and c pups received normal diet after weaning and male offspring were sac ... | 2011 | 21448850 |
| chemotherapy/chemoradiation in anal cancer: a systematic review. | results from recent phase iii trials in anal cancer failed to show any benefit for neoadjuvant chemotherapy (nact) with cisplatin, or cisplatin-based consolidation chemotherapy compared to chemoradiation alone for loco-regional control, disease-free survival (dfs) and overall survival (os). | 2011 | 21450408 |
| detection of single-base mutation in rna using t4 rna ligase-based nick-joining or dnazyme-based nick-generation. | a single nucleotide polymorphism (snp) is a common genetic variation when a single nucleotide differs between members of a species or paired chromosome. due to its association with disease susceptibility and drug resistance, snp detection is of great value in studying the variation in drug responses. here we present two quantitative snp detection methods for a single-base mismatch in rna, based on nick-joining and nick-generating activities of t4 rna ligase and dnazyme, respectively. t4 rna liga ... | 2011 | 21453671 |
| qsar classification models for the prediction of endocrine disrupting activity of brominated flame retardants. | the identification of potential endocrine disrupting (ed) chemicals is an important task for the scientific community due to their diffusion in the environment; the production and use of such compounds will be strictly regulated through the authorization process of the reach regulation. to overcome the problem of insufficient experimental data, the quantitative structure-activity relationship (qsar) approach is applied to predict the ed activity of new chemicals. in the present study qsar classi ... | 2011 | 21454014 |
| dynamics of the t4 bacteriophage dna packasome motor: endonuclease vii resolvase release of arrested y-dna substrates. | conserved bacteriophage atp-based dna translocation motors consist of a multimeric packaging terminase docked onto a unique procapsid vertex containing a portal ring. dna is translocated into the empty procapsid through the portal ring channel to high density. in vivo the t4 phage packaging motor deals with y- or x-structures in the replicative concatemer substrate by employing a portal-bound holliday junction resolvase that trims and releases these dna roadblocks to packaging. here using dye-la ... | 2011 | 21454482 |
| postvoid residuals remain unchanged in patients with postoperative thoracic epidural analgesia after thoracotomy. | we found in previous studies that thoracic epidural analgesia (tea) after open renal surgery via lumbotomy significantly impaired bladder function with decreased detrusor contractility and increased postvoid residuals under urodynamic assessment. here we evaluated the effect of tea on bladder emptying in patients undergoing thoracotomy. | 2011 | 21455089 |
| outlasting corticomotor excitability changes induced by 25 hz whole-hand mechanical stimulation. | the objective was to investigate if whole-hand mechanical stimulation (mstim) in the tapping-flutter frequency range induces outlasting post-stimulus changes in the hand region of the primary motor cortex. mstim was delivered to 12 healthy subjects for 20 min using a therapeutic stimulation device (swisswing bmr 2000). frequencies of 10 and 25 hz were tested in separate sessions, and for control additionally the foot sole was stimulated at 25 hz. motor evoked potentials (meps) after single (recr ... | 2011 | 21455615 |
| implicit motor learning promotes neural efficiency during laparoscopy. | an understanding of differences in expert and novice neural behavior can inform surgical skills training. outside the surgical domain, electroencephalographic (eeg) coherence analyses have shown that during motor performance, experts display less coactivation between the verbal-analytic and motor planning regions than their less skilled counterparts. reduced involvement of verbal-analytic processes suggests greater neural efficiency. the authors tested the utility of an implicit motor learning i ... | 2011 | 21455805 |
| identification of differentially expressed thyroid hormone responsive genes from the brain of the mexican axolotl (ambystoma mexicanum). | the mexican axolotl (ambystoma mexicanum) presents an excellent model to investigate mechanisms of brain development that are conserved among vertebrates. in particular, metamorphic changes of the brain can be induced in free-living aquatic juveniles and adults by simply adding thyroid hormone (t4) to rearing water. whole brains were sampled from juvenile a. mexicanum that were exposed to 0, 8, and 18days of 50nm t4, and these were used to isolate rna and make normalized cdna libraries for 454 d ... | 2011 | 21457787 |
| characterization and comparison of the full 3' and 5' untranslated genomic regions of diverse isolates of infectious salmon anaemia virus by using a rapid and universal method. | the 3' and 5' untranslated regions (utrs) of the gene segments of orthomyxoviruses interact closely with the polymerase complex and are important for viral replication and transcription regulation. despite this, the 3' and 5' rna utrs of the infectious salmon anaemia virus (isav) genome have only been partially characterized and little is known about the level of conservation between different virus subtypes. this report details for the first time, the adaptation of a rapid method for the simult ... | 2011 | 21458495 |
| a rexinoid antagonist increases the hypothalamic-pituitary-thyroid set point in mice and thyrotrope cells. | retinoid x receptor (rxr) signaling influences thyrotrope function. synthetic rxr agonists, rexinoids, can cause central hypothyroidism. to test the hypothesis that endogenous rexinoids contribute to the tsh 'set point', tat1 mouse thyrotrope cells were treated with a rexinoid antagonist, lg101208. increasing concentrations of lg101208 significantly increased tshß mrna levels, indicating that the rexinoid antagonist may interfere with rxr-signaling by an endogenous rexinoid in thyrotropes. when ... | 2011 | 21458528 |
| [thyroid hormone resistance syndromes]. | thyroid hormone resistance syndromes are a group of genetic conditions characterized by decreased tissue sensitivity to thyroid hormones. three syndromes, in which resistance to hormone action is respectively due to mutations in the gene encoding for thyroid hormone receptor trß, impaired t4 and t3 transport, and impaired conversion of t4 to t3 mediated by deiodinases. an updated review of each of these forms of resistance is provided, and their pathogenetic mechanisms and clinical approaches ar ... | 2011 | 21459689 |
| phospholipase activities in clinical and environmental isolates of acanthamoeba. | the pathogenesis and pathophysiology of acanthamoeba infections remain incompletely understood. phospholipases are known to cleave phospholipids, suggesting their possible involvement in the host cell plasma membrane disruption leading to host cell penetration and lysis. the aims of the present study were to determine phospholipase activities in acanthamoeba and to determine their roles in the pathogenesis of acanthamoeba. using an encephalitis isolate (t1 genotype), a keratitis isolate (t4 geno ... | 2011 | 21461262 |
| fish thyroidal and stress responses in contamination monitoring--an integrated biomarker approach. | xenobiotics may affect fish endocrine system, making endocrine responses relevant in pollution monitoring. five critical sites in ria de aveiro (portugal), having different contamination profiles, were assessed in comparison to a reference site (torreira), focusing on liza aurata stress (plasma cortisol, glucose and lactate) and thyroidal (plasma thyroid stimulating hormone-tsh, thyroxine-t4 and triiodothyronine-t3) responses. l. aurata at vagos (pahs contaminated) and laranjo (mercury contamina ... | 2011 | 21463897 |
| outcomes of hepatic resection for huge hepatocellular carcinoma (=10?cm in diameter). | the object of the current study was to review the outcomes of hepatic resection for hepatocellular carcinoma (hcc)?=?10?cm. | 2011 | 21465490 |
| carbon ion therapy for advanced sinonasal malignancies: feasibility and acute toxicity. | to evaluate feasibility and toxicity of carbon ion therapy for treatment of sinonasal malignancies. first site of treatment failure in malignant tumours of the paranasal sinuses and nasal cavity is mostly in-field, local control hence calls for dose escalation which has so far been hampered by accompanying acute and late toxicity. raster-scanned carbon ion therapy offers the advantage of sharp dose gradients promising increased dose application without increase of side-effects. | 2011 | 21466696 |
| ischemic post-conditioning attenuates the intestinal injury induced by limb ischemia/reperfusion in rats. | the purpose of this study was to investigate the protective effects of ischemic post-conditioning on damage to the barrier function of the small intestine caused by limb ischemia-reperfusion injury. male wistar rats were randomly divided into 3 groups (n = 36 each): sham operated (group s), lower limb ischemia-reperfusion (group lir), and post-conditioning (group pc). each group was divided into subgroups (n = 6) according to reperfusion time: immediate (0 h; t1), 1 h (t2), 3 h (t3), 6 h (t4), 1 ... | 2011 | 21468513 |
| novel mutation in mct8 gene in a brazilian boy with thyroid hormone resistance and severe neurologic abnormalities. | mct8 is a cellular transporter of thyroid hormones important in their action and metabolization. we report a male patient with the novel inactivating mutation 630insg in the coding region in exon 1 of mct8. he was characterized clinically by severe neurologic impairment (initially with global hypotonia, later evolving with generalized hypertonia), normal growth during infancy, reduced weight gain, and absence of typical signs and symptoms of hypothyroidism, while the laboratory evaluation disclo ... | 2011 | 21468521 |
| effect of zinc and iron fortification of the feed on liver and thyroid function in rats. | changes in plasma glutamate oxaloacetate transaminase (got), glutamate pyruvate transaminase (gpt), triiodothyronine (t3), and thyroxin (t4) of male rats, following 8 weeks of administration of different concentrations of elemental iron (ei), sodium iron ethylenediaminetetraacetate (nafeedta), zinc sulfate (znso(4)), and zinc oxide (zno) in whole wheat flour were investigated. liver enzymes and thyroid hormones were determined using colorimetric methods and enzyme immune assay, respectively. ing ... | 2011 | 21468629 |
| sagittal balance of thoracic lordoscoliosis: anterior dual rod instrumentation versus posterior pedicle screw fixation. | posterior pedicle screw fixation is now the standard treatment for surgical correction of idiopathic scoliosis and has largely replaced anterior techniques, but there have been reports describing a lordogenic effect of segmental pedicle screw instrumentation in the thoracic spine. this clinical study compared anterior dual rod instrumentation with posterior pedicle screw fixation for idiopathic thoracic lordoscoliosis, including 42 patients (7 male, 35 female; average age 16 years, range 12-34) ... | 2011 | 21468646 |
| specialization versus adaptation: two strategies employed by cyanophages to enhance their translation efficiencies. | effective translation of the viral genome during the infection cycle most likely enhances its fitness. in this study, we reveal two different strategies employed by cyanophages, viruses infecting cyanobacteria, to enhance their translation efficiency. cyanophages of the t7-like podoviridae family adjust their gc content and codon usage to those of their hosts. in contrast, cyanophages of the t4-like myoviridae family maintain genomes with low gc content, thus sometimes differing from that of the ... | 2011 | 21470965 |
| maternal thyroid function during pregnancy and behavioral problems in the offspring: the generation r study. | maternal thyroid function during pregnancy is implicated in the neurodevelopment of the offspring, yet little is known about the effect of maternal thyroid parameters on the behavior of children. we investigated the association of maternal thyroid function during the first half of pregnancy with parent-reported problem behavior of the offspring up to age of 3 y. in the generation r study, a population-based cohort of 3736 children and their mothers, data on maternal thyroid function and child's ... | 2011 | 21471776 |
| colorectal cancer and 18fdg-pet/ct: what about adding the t to the n parameter in loco-regional staging? | to evaluate whether fdg-positron emission tomography (pet)/computed tomography (ct) may be an accurate technique in the assessment of the t stage in patients with colorectal cancer. | 2011 | 21472100 |
| dna ligases. | the dna ligase enzyme family catalyzes the formation of a phosphodiester bond between juxtaposed 5'-phosphate and 3'-hydroxyl termini in duplex dna. this activity can seal nicks in duplex dna or join double-stranded dna fragments having either blunt or cohesive ends. dna ligases are central enzymes in molecular biology, nucleic acid research, and in next-generation sequencing applications. reaction conditions and applications for t4 dna ligase, e. coli dna ligase, and thermostable dna ligases ar ... | 2011 | 21472697 |
| surgical outcomes and survival after extended multiorgan resection for t4 gastric cancer. | background: extended multiorgan resection (emr) for locally advanced (t4) gastric cancer remains controversial. the aim of this study was to evaluate the effectiveness of this approach with regard to morbidity, mortality, and survival. methods: between 2005 and 2009, 41 patients underwent aggressive surgery for clinical t4 gastric cancer. univariate and multivariate analyses were used to identify prognostic factors for surgical outcomes and survival in these patients. results: curative resection ... | 2011 | 21474116 |
| identification of interleukin 2, 6, and 8 levels around miniscrews during orthodontic tooth movement. | the aim of this study was to identify the levels of interleukin (il)-2, il-6, and il-8 around miniscrews used for anchorage during canine distalization. sixteen patients (eight males and eight females; mean age, 16.6 ± 2.4 years) who were treated with bilateral upper first premolar extractions were included in the study. thirty-two maxillary miniscrew implants were placed bilaterally in the alveolar bone between the maxillary second premolars and first molars as anchorage units for maxillary can ... | 2011 | 21474566 |
| microrna-21 induces cell proliferation and invasion in esophageal squamous cell carcinoma. | it has been suggested that microrna-21 (mir-21) functions as an oncogene, as it is overexpressed in many types of tumors compared to adjacent normal tissues. however, the role of mir-21 has yet to be studied in esophageal squamous cell carcinoma (escc). mir-21 expression was quantified by real-time reverse transcription polymerase chain reaction in 38 escc specimens and their paired non-cancerous mucosa, and in 15 esophageal cancer cell lines (te1-15). mir-21 expression levels in escc tissue wer ... | 2009 | 21475818 |
| physiological and therapeutical roles of ginger and turmeric on endocrine functions. | the natural product ginger (zingiber officinale) has active constituents gingerol, shogaol and zerumbone, while turmeric (curcuma longa) contains three active major curcuminoids, namely, curcumin, demethoxycurcumin, and bisdemethoxycurcumin. they have the same scientific classification and are reported to have anti-inflammatory and many therapeutic effects. this article reviews the physiological and therapeutic effects of ginger and turmeric on some endocrine gland functions, and signal pathways ... | 2011 | 21476200 |
| predicting ideal spinopelvic balance in adult spinal deformity. | object spinopelvic balance is based on the theory that adjacent segments of the spine are related and influenced by one another. by understanding the correlation between the thoracolumbar spine and the pelvis, a concept of spinopelvic balance can be applied to adult deformity. the purpose of this study was to develop a mathematical relationship between the pelvis and spine and apply it to a population of adults who had undergone spinal deformity surgery to determine whether patients in spinopelv ... | 2011 | 21476795 |
| image-guided radiotherapy for prostate cancer: a prospective trial of concomitant boost using indium-111-capromab pendetide (prostascint) imaging. | purpose: to evaluate, in a prospective study, the use of (111)in-capromab pendetide (prostascint) scan to guide the delivery of a concomitant boost to intraprostatic region showing increased uptake while treating the entire gland with intensity-modulated radiotherapy for localized prostate cancer. methods and materials: from september 2002 to november 2005, 71 patients were enrolled. planning pelvic ct and (111)in-capromab pendetide scan images were coregistered. the entire prostate gland receiv ... | 2011 | 21477947 |
| implications of the inability of listeria monocytogenes egd-e to grow anaerobically due to a deletion in the class iii nrdd ribonucleotide reductase for its use as a model laboratory strain. | listeria monocytogenes is a gram-positive facultative intracellular bacterium that causes life-threatening diseases in humans. it grows and survives in environments of low oxygen tension and under conditions of strict anaerobiosis. oxygen-limiting conditions may be an important factor in determining its pathogenicity. l. monocytogenes serovar 1/2a strain egd-e has been employed intensively to elucidate the mechanisms of intracellular multiplication and virulence. listeria possesses genes encodin ... | 2011 | 21478338 |
| thyroid hormones and the central nervous system of mammals (review). | the thyroid hormones (ths) l-thyroxine (t4) and l-triiodothyronine (t3) have a profound influence on the development and maturation of the mammalian brain, both before and after birth. any impairment in the supply of ths to the developing nervous system leads to severe and irreversible changes in both the overall architecture and functions of the brain and causes, in humans, neurological and motor deficits known as cretinism. pronounced neurological symptoms are also commonly observed in adult p ... | 2008 | 21479409 |
| [effect of adipose differentiation-related protein on the apoptosis of h9c2 cells by palmitic acid.] | aim: to construct a eukaryotic expression vector for expressing adipose differentiation-related protein(adrp) protein and obtain a stable transfected h9c2 cell line. methods: (1)the full length dna fragment of adrp gene was amplified by pcr from the myocardium of adult sd rats and was inserted into pegfp-c1 with t4 ligase. after the identification of digestion and sequencing on the recombinant pegfp-c1-adrp, the recombinant was transformed into e.coli strain dh5α.and the positive recombinant pla ... | 2011 | 21481311 |
| phage t4-induced dttp accretion bolsters a trnase-based host defense. | the anticodon nuclease (acnase) prrc is silenced in escherichia coli by an associated dna restriction-modification protein, activated by the phage t4-encoded anti-dna restriction factor stp and counteracted by t4's trna repair enzymes polynucleotide kinase and rna ligase 1. hence, only trna repair-deficient phages succumb to prrc's restriction. prrc's abc-atpase motor domains are implicated in driving its activation by hydrolyzing gtp and in stabilizing the activated acnase by avidly binding dtt ... | 2011 | 21481433 |
| effects of sulphur and thiobacillusthioparus on cow manure aerobic composting. | a simulated aerobic composting experiment was used to explore the effects of sulphur and thiobacillusthioparus during six manure composting treatments. the addition of sulphur led to a decrease of the ph level within the range 6-6.3, which was lower than the control treatment (ck). the concentration of ammonium nitrogen in t1 (0.25% sulphur), t2 (0.5% sulphur), t3 (0.25% sulphur+t. thioparus) and t4 (0.5% sulphur+t. thioparus) were much higher than the ammonium n in ck. the results indicated tha ... | 2011 | 21482106 |
| inhibition of tumor angiogenesis in lung cancer by t4 phage surface displaying mvegfr2 vaccine. | vascular endothelial growth factor (vegf) has been known as a potential vasculogenic and angiogenic factor and its receptor (vegfr2) is a major receptor to response to the angiogenic activity of vegf. the technique that to break the immune tolerance of "self-antigens" associated with angiogenesis is an attractive approach for cancer therapy with t4 phage display system. in this experiment, mouse vegfr2 was constructed on t4 phage nanometer-particle surface as a recombinant vaccine. t4-mvegfr2 re ... | 2011 | 21482223 |
| peri-implant tissue response following connective tissue and bone grafting in conjunction with immediate single-tooth replacement in the esthetic zone: a case series. | purpose: this case series evaluated the peri-implant tissue response following extraction and immediate placement and restoration of an implant in conjunction with subepithelial connective tissue grafting (sctg) and bone grafting in the esthetic zone. implant success rates and the peri-implant tissue response were also reported. methods and materials: ten patients (four men, six women) with a mean age of 48 years (range, 35 to 70) underwent extraction and immediate tooth replacement with sctg an ... | 2011 | 21483896 |
| [correlation between serum thyroid hormone and dopamine levels and chinese medicine syndrome types]. | to analyze the correlation between changes of thyroid hormone (th), dopamine (da) and chinese medicine syndrome types by detecting contents of serum th and da in insomnia, thus to explore objective indices of chinese medicine syndrome types. | 2011 | 21485074 |
| evaluation of physical properties of enamel after microabrasion, polishing, and storage in artificial saliva. | this study evaluated the effect of microabrasion and polishing on the microhardness and roughness of bovine enamel, and the effect of artificial saliva on the hardness of enamel. bovine enamel blocks were used, forming the groups (n = 48): gi-37% phosphoric acid and pumice, gii--opalustre, and giii--whiteness rm. the groups were divided into different subgroups: (a) diamond paste, (b) fluoride prophylactic paste, and (c) without polishing. hardness tests were carried out at the following set tim ... | 2011 | 21487176 |
| no causal relationship between yersinia enterocolitica infection and autoimmune thyroid disease: evidence from a prospective study. | the objective of this study was to evaluate prospectively the relationship between yersinia enterocolitica (ye) infection and the development of overt autoimmune hypo- or hyperthyroidism (study a) and the de novo occurrence of thyroid antibodies (study b). this was a prospective cohort study of 790 euthyroid women who were first- or second-degree relatives of autoimmune thyroid disease (aitd) patients. follow-up was 5 years, with annual assessments. study a was a nested case-control study in whi ... | 2011 | 21488870 |
| increased expression of transcription factor tfap2α correlates with chemosensitivity in advanced bladder cancer. | abstract: | 2011 | 21489314 |
| revisiting low-dose total skin electron beam therapy in mycosis fungoides. | purpose: total skin electron beam therapy (tsebt) is a highly effective treatment for mycosis fungoides (mf). the standard course consists of 30 to 36 gy delivered over an 8- to 10-week period. this regimen is time intensive and associated with significant treatment-related toxicities including erythema, desquamation, anhydrosis, alopecia, and xerosis. the aim of this study was to identify a lower dose alternative while retaining a favorable efficacy profile. methods and materials: one hundred t ... | 2011 | 21489711 |
| s-ketamine modulates hyperalgesia in patients with chronic pancreatitis pain. | upper abdominal pain is a dominant feature of chronic pancreatitis. a key phenomenon in this context is hyperalgesia, typically associated with n-methyl-d-aspartate receptor activation. this exploratory study evaluates acute effects of s-ketamine, a noncompetitive n-methyl-d-aspartate antagonist, in modulating generalized hyperalgesia in chronic pancreatitis pain. | 2011 | 21490522 |
| the effect of milrinone on the intraoperative hemodynamics during off-pump coronary bypass surgery in patients with an elevated echocardiographic index of the ventricular filling pressure. | hemodynamic derangement during off-pump coronary artery bypass surgery (opcab) is mainly attributed to impaired filling and diastolic dysfunction. an elevated ratio of the mitral velocity to the early-diastolic velocity of the mitral annulus (e/e' > 15) is a relatively new indicator of diastolic function, and this was reported to be associated with impaired hemodynamics during opcab. we investigated the efficacy of milrinone on the perioperative hemodynamics and short term outcomes of patients w ... | 2011 | 21490820 |