Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| chlamydia trachomatis infection in female partners of circumcised and uncircumcised adult men. | male circumcision has been shown to reduce the risk of acquiring and transmitting a number of venereal infections. however, little is known about the association between male circumcision and the risk of chlamydia trachomatis infection in the female partner. the authors pooled data on 305 adult couples enrolled as controls in one of five case-control studies of invasive cervical cancer conducted in thailand, the philippines, brazil, colombia, and spain between 1985 and 1997. women provided blood ... | 2005 | 16177149 |
| effects of repeated chlamydia pneumoniae inoculations on aortic lipid accumulation and inflammatory response in c57bl/6j mice. | chlamydia pneumoniae is a common respiratory tract pathogen, and persistent infections have been associated with atherosclerosis. we studied the effects of repeated chlamydial inoculations on the inflammatory response and on aortic lipid accumulation in c57bl/6j mice. mice fed a diet supplemented with 0.2% cholesterol were infected three or six times with c. pneumoniae every fourth week. sera and lungs were analyzed for inflammatory responses, lung tissues were tested for the presence of c. pneu ... | 2005 | 16177317 |
| toll-like receptor 2 mediates persistent chemokine release by chlamydia pneumoniae-infected vascular smooth muscle cells. | the intracellular bacterium chlamydia pneumoniae is present in many atherosclerotic lesions, where it could promote inflammation. this study determined whether monocyte chemoattractant protein 1 (mcp-1) release is stimulated in vascular smooth muscle cells (vsmcs) that are exposed to or infected by c pneumoniae and whether toll-like receptor 2 (tlr2) or tlr4 mediate these effects. | 2005 | 16179594 |
| the complications of hypertension in pregnancy. | the hypertensive disorders of pregnancy remain a leading cause of maternal and perinatal morbidity and mortality in europe and north america. pre-eclampsia, which is proteinuric gestational hypertension, accounts for the majority of the excess risks and is defined by the maternal syndrome. the maternal syndrome of pre-eclampsia is characterised by a systemic inflammatory response and its sequelae. systematic multisystem evaluation of pre-eclampsia, evidence-based antihypertensive therapy, and th ... | 2005 | 16179895 |
| [efficacy and safety of pristinamycin vs amoxicillin in community acquired pneumonia in adults]. | evaluation of efficacy and safety of pristinamycin (pri), compared with amoxicillin (amx), both at 3 g daily for 7 to 10 days in adults with community-acquired pneumonia (cap). | 2005 | 16181747 |
| detection of chlamydia pneumoniae and helicobacter pylori in atherosclerotic plaques of carotid artery by polymerase chain reaction. | a possible role of some microorganisms has been proposed in the pathogenesis of atherosclerosis, but it is still an unresolved issue. we investigated the presence of chlamydia pneumoniae and helicobacter pylori dna in carotid artery atherosclerotic plaques by using pcr. | 2006 | 16183317 |
| chlamydia pneumoniae, herpes simplex virus and cytomegalovirus in symptomatic and asymptomatic high-grade internal carotid artery stenosis. does infection influence plaque stability? | current debates are focused on inflammatory processes in atherosclerotic lesions as a possible pathomechanism for destabilization and thrombembolism. in this prospective study the role of systemic and local infection in patients with high-grade internal carotid artery stenosis (ica) was evaluated. | 2005 | 16184834 |
| [atypical pneumonia]. | international epidemiologic surveys show that apart from community acquired "typical" pneumonia the number of cases caused by atypical pathogens are increasing. a number of problems are to be faced while diagnosing and treating the lower respiratory tract infections due to atypical pathogens. the article gives a detailed overview of pneumonia caused by chlamydia pneumoniae, chlamydia psittaci, mycoplasma pneumoniae, coxiella burnetti and legionella species, and emphasizes that these pathogens sh ... | 2005 | 16184877 |
| chlamydia pneumoniae infection predicts a reduced risk for subsequent atopic disease. | to investigate long-term effects on children previously infected with chlamydia pneumoniae. | 2005 | 16188772 |
| no value in antibiotic therapy for hd. | 2005 | 16189853 | |
| chlamydia pneumoniae in an ex vivo human artery culture model. | the role of the obligate intracellular pathogen chlamydia pneumoniae in the development of atherosclerosis could not be completely clarified. reasons are the highly discrepant results obtained in the hitherto existing studies and the lack of an experimental system allowing the direct examination of chlamydial effects in the human vasculature. we established a human ex vivo organ culture model for the characterization of vascular chlamydial infection. ninety sections of renal arteries, obtained f ... | 2006 | 16202418 |
| chlamydia pneumoniae immunoreactivity in coronary artery plaques of patients with acute coronary syndromes and its relation with serology. | an association between chlamydia pneumoniae (cpn) infection and coronary artery disease has been reported and examined by different techniques. however, its immunoreactivity in coronary artery plaques of patients with acute coronary syndrome (acs) and its relation with serology are less well defined. | 2005 | 16209964 |
| chlamydia pneumoniae burden in carotid arteries is associated with upregulation of plaque interleukin-6 and elevated c-reactive protein in serum. | chlamydia pneumoniae (cpn) infection of vascular smooth muscle cells increases interleukin-6 (il-6) secretion in vitro. in vivo, il-6 stimulates liver c-reactive protein (crp) production. because serum levels of il-6 and crp are independent risk factors for stroke and myocardial infarction (mi), we investigated whether cpn burden in carotid plaques might provide a link between plaque il-6 expression and elevated serum levels of il-6 and crp. | 2005 | 16210572 |
| acute chlamydia pneumoniae infection with heat-shock-protein-60-related response in patients with acute coronary syndrome. | recent evidence has suggested an association between chlamydia pneumoniae infection and coronary atherosclerosis. a significant association has also been detected between heat shock protein (hsp) 60 antibody and the severity of coronary atherosclerosis. the aim of this study was to define the relationship between instability of ischemic heart disease (ihd) and serum levels of hsp60 and c. pneumoniae antibodies. blood samples for the measurement of serum antibody titers were obtained from 1131 pa ... | 2005 | 16216593 |
| therapeutic approaches to chlamydia infections. | chlamydia trachomatis ocular and urogenital infections represent major public health problems, whereas chlamydophila pneumoniae is a common aetiological agent of community-acquired pneumonia. the obligate intracellular lifestyle of these established pathogens poses challenges to both their diagnosis and treatment. tetracyclines, macrolides and quinolones remain the antimicrobials of choice for the treatment of infections due to chlamydiaceae. | 2005 | 16218888 |
| protective effects of simvastatin on coronary artery function in swine with acute infection. | the risk for coronary events may rise during acute infection. perturbation in coronary endothelial function emerges as one important link. we investigated whether simvastatin could protect the coronary arterial function from the adverse effects of acute infection in swine. | 2006 | 16223501 |
| aetiological role of viral and bacterial infections in acute adult lower respiratory tract infection (lrti) in primary care. | lower respiratory tract infections (lrti) are a common reason for consulting general practitioners (gps). in most cases the aetiology is unknown, yet most result in an antibiotic prescription. the aetiology of lrti was investigated in a prospective controlled study. | 2006 | 16227331 |
| macrolides for chronic asthma. | asthma is a chronic disease of the airways in which inflammation of the respiratory mucosa plays a crucial role. the mechanisms responsible for the maintaining of this inflammatory response are only partially known and there is evidence that a role could be paid by chronic infection by intracellular pathogens (such as chlamydia pneumoniae). macrolides are antibiotics with both antimicrobic and antiinflammatory activities and thus their use in asthmatic patients could lead to reduction of the air ... | 2005 | 16235309 |
| what's bugging you? | 2005 | 16237227 | |
| exposure to mycobacteria primes the immune system for evolutionarily diverse heat shock proteins. | during stress conditions, such as infection, the synthesis of heat shock proteins (hsps) in microorganisms is upregulated. since a high degree of homology exists within each hsp family, we postulated that exposure to microorganisms could prime the immune system for evolutionarily diverse hsps. we tested this hypothesis by priming mice with three microorganisms, namely, mycobacterium bovis bcg, mycobacterium vaccae, and chlamydia pneumoniae. after this, mice received a dose of the various hsps. w ... | 2005 | 16239573 |
| [heat shock proteins and their characteristics]. | the main adaptable response to increased temperature is heat shock response resulting in induction of proteins called heat shock proteins (hsp). they are present in all cells under proper growth conditions and they create 5-10% of the whole protein contents. hsp were divided into five basic groups according to their approximate molecular mass, expressed in kda and called respectively: hsp 100, hsp 90, hsp 70, hsp 60 and small hsp. heat shock proteins can act like antigens in many infectious dise ... | 2005 | 16245438 |
| chlamydia pneumoniae, harmful only for peripheral arteries? | 2006 | 16257071 | |
| chlamydia pneumoniae ap endonuclease iv could cleave ap sites of double- and single-stranded dna. | endonuclease iv gene, the only putative ap endonuclease of c. pneumoniae genome, was cloned into pet28a. recombinant c. pneumoniae endonuclease i v (cpendoiv) was expressed in e. coli and purified to homogeneity. cpendoiv has endonuclease activity against apurinic/apyrimidinic sites (ap sites) of double-stranded (ds) oligonucleotides. ap endonuclease activity of cpendoiv was promoted by divalent metal ions mg2+ and zn2+, and inhibited by edta. the natural (a, t, c and g) and modified (u, i and 8 ... | 2005 | 16257276 |
| epidemiology and bacteriology of bacterial pneumonias. | an understanding of the epidemiology and bacteriology of pneumonia in childhood is frustrated by the difficulties in making an aetiological diagnosis in young children. incidence figures for community-acquired pneumonia are derived from the 1970s and 1980s and suggest that the incidence is higher in young children than in older children: approximately 40/1000/year <5 years of age and 15/1000/year aged 5-14 years. certain pathogens are associated with pneumonia in different age groups, mycoplasma ... | 2000 | 16263435 |
| the chlamydia pneumoniae type iii secretion-related lcrh gene clusters are developmentally expressed operons. | two chlamydial homologues of the yersinia lcrh chaperone for type iii secretion system structural components are present within separate gene clusters. quantitative transcriptional analyses demonstrated that each cluster is differentially regulated and expressed as an operon using major sigma factor elements, suggesting the presence of more elaborate developmental regulation mechanisms in chlamydiae. | 2005 | 16267309 |
| serum igg and iga antibodies to chlamydia pneumoniae and severity of emphysema. | chronic chlamydia pneumoniae infection has been identified serologically in patients with copd. the aim of this study was to examine whether the severity of emphysema is related to elevated antibody titres against c. pneumoniae. | 2005 | 16268909 |
| differential expression of chlamydial signal transduction genes in normal and interferon gamma-induced persistent chlamydophila pneumoniae infections. | characteristic features of the persistent chlamydial developmental cycle, associated with chronic infections in both humans and animals, include the generation of non-replicative, morphologically aberrant bodies which are distinct from normal propagating reticulate bodies. previous studies have correlated these morphological and metabolic changes with differential expression of diverse functional subsets of chlamydial genes. to further investigate these correlations, we compared mrna expression ... | 2006 | 16269262 |
| tobacco smoke induces a persistent, but recoverable state in chlamydia pneumoniae infection of human endothelial cells. | we investigated the extent to which tobacco smoke could induce persistence of chlamydia pneumoniae in human endothelial cells. aortic and coronary artery endothelia were infected in the absence or presence of non-cytotoxic concentrations of tobacco smoke medium. following exposure to smoke medium, chlamydial inclusions were smaller and demonstrated fewer genome copies as determined by real-time pcr. enumeration of inclusion-forming units (ifu) established a significant smoke-mediated, dose-depen ... | 2005 | 16271847 |
| chlamydia pneumoniae in foci of "early" calcification of the tunica media in arteriosclerotic arteries: an incidental presence? | only a few previous works investigated the involvement of chlamydia pneumoniae (chlamydophila pneumoniae) in arterial calcification. the present study investigated a possible association between c. pneumoniae and medial calcification. carotid artery segments obtained by endarterectomy from 60 patients were examined by pcr and immunohistochemistry to identify the presence of c. pneumoniae. arterial specimens showing double-positive (n = 17), double-negative (n = 22), and single-positive results ( ... | 2006 | 16272196 |
| chlamydophila (chlamydia) pneumoniae serology and asthma in adults: a longitudinal analysis. | many cross-sectional studies have found an association between chlamydophila pneumoniae infection and asthma, and a possible causative role of c pneumoniae infection in asthma pathogenesis has been proposed. no longitudinal studies have been undertaken to estimate the effect on asthma incidence of previous or chronic infection. | 2005 | 16275386 |
| evaluation of a western blot method for the detection of yersinia antibodies: evidence of serological cross-reactivity between yersinia outer membrane proteins and borrelia burgdorferi. | yersinia enterocolitica and yersinia pseudotuberculosis have been identified as causative organisms of reactive arthritis in humans. we evaluated a western blot assay which uses yersinia outer membrane proteins as antigens for the detection of yersinia antibodies as a replacement for the complement fixation (cf) assay. clinical agreement, sensitivity, and specificity were determined by testing 19 positive and 21 negative serum samples by the cf assay, western blot assay, and enzyme-linked immuno ... | 2005 | 16275939 |
| dental infections and cardiovascular diseases: a review. | accumulating evidence suggests that chronic infections, such as periodontitis, are associated with increased risk for cardiovascular diseases (cvd). the mechanisms behind the association are not known. like herpes viruses and chlamydia pneumoniae, periodontal pathogens cause atherosclerosis in experimental animals and have been found in human atherosclerotic lesions. higher concentrations of total and low density lipoprotein (ldl) cholesterol and triglycerides and lower concentrations of high de ... | 2005 | 16277580 |
| chlamydia pneumoniae growth inhibition in human monocytic thp-1 cells and human epithelial hep-2 cells by a novel phenoxazine derivative. | in this study the effects of 2-amino-phenoxazine-3-one (phenoxazine derivate, phx-3) on chlamydia (chlamydophila) pneumoniae growth in human monocytic thp-1 cells as well as human epithelial hep-2 cells were examined. cells were infected with bacteria at an m.o.i. of 10 by centrifugation. after washing to remove any remaining bacteria, the cells were incubated with or without phx-3 in the presence or absence of tryptophan for 72 h. the bacteria in cells were assessed by staining of chlamydial in ... | 2005 | 16278427 |
| outbreak of chlamydophila pneumoniae infection in long-term care facilities and an affiliated hospital. | this paper reports an outbreak of chlamydophila pneumoniae infection in long-term care facilities and an affiliated hospital. the outbreak involved rapid spread of infection, and was inconsistent with several outbreaks experienced among younger populations. in addition, there were differences in the incidences among facilities and the affiliated hospital in relation to mean age. our findings indicate that it is possible that elderly residents may be more susceptible to acquiring this infection. ... | 2005 | 16278441 |
| a monoclonal antibody against a carbohydrate epitope in lipopolysaccharide differentiates chlamydophila psittaci from chlamydophila pecorum, chlamydophila pneumoniae, and chlamydia trachomatis. | lipopolysaccharide (lps) of chlamydophila psittaci but not of chlamydophila pneumoniae or chlamydia trachomatis contains a tetrasaccharide of 3-deoxy-alpha-d-manno-oct-2-ulopyranosonic acid (kdo) of the sequence kdo(2-->8)[kdo(2-->4)] kdo(2-->4)kdo. after immunization with the synthetic neoglycoconjugate antigen kdo(2-->8)[kdo(2-->4)]kdo(2-->4) kdo-bsa, we obtained the mouse monoclonal antibody (mab) s69-4 which was able to differentiate c. psittaci from chlamydophila pecorum, c. pneumoniae, and ... | 2006 | 16282606 |
| infection with simkania negevensis in brooklyn, new york. | simkania negevensis is a chlamydia-like intracellular organism that is prevalent in populations from a wide range of geographic areas. the role of the organism in respiratory disease in the united states is unknown. | 2005 | 16282935 |
| presence of chlamydia pneumoniae dna in the artery wall--biomarker of coronary artery disease. | many authors have shown an association between chlamydia pneumoniae (cpn) infection and coronary artery disease (cad). however, whether cpn infection demonstrated by cpn dna presence in the artery wall plays an important role in pathogenesis of cad and acute coronary events (i.e. unstable angina) remains to be elucidated. one hundred and fifteen consecutive patients with cad (51 with unstable angina and 64 with stable angina) were compared with 52 control subjects with aortic valve disease witho ... | 2005 | 16285208 |
| tigecyclin--the first glycylcycline to undergo clinical development: an overview of in vitro activity compared to tetracycline. | tetracycline antimicrobials are characterised by a broad-spectrum of antibacterial activity which includes gram-positive, most gram-negative, anaerobic and "atypical" (legionella pneumophila, chlamydophila pneumoniae and mycoplasma pneumoniae) species. however, the original clinical utility of the tetracyclines has been compromised as a result of increasing resistance to them among previously susceptible, common pathogens. research into structure-activity relationships among various tetracycline ... | 2005 | 16285353 |
| association between seroprevalence of anti-chlamydial antibodies and long-term cardiovascular mortality in chronic hemodialysis patients. | chlamydial infection has been suspected in the pathogenesis of ischemic heart disease. however, it remains undetermined if persistent chlamydial infection is related to cardiovascular mortality in regular hemodialysis (hd) patients. we measured chlamydia pneumoniae (cp) antibody seropositivity in 154 hd subjects (age 59 +/- 11 years, time on hd 13 +/- 7 years, male/female = 101/53), and prospectively examined an association between cp antibody status and cardiovascular death for 56 months of fol ... | 2006 | 16288759 |
| novel enzyme immunoassay utilizing lipopolysaccharide-binding protein as a capture molecule for the measurement of chlamydial lipopolysaccharide in serum. | chlamydia pneumoniae causes respiratory tract infections. it has a tendency to cause persistent infections, which have been associated with several chronic diseases (e.g., atherosclerosis). at present, there is no reliable method for the diagnosis of chronic c. pneumoniae infection. we developed a novel enzyme immunoassay (eia) for the quantification of chlamydial lipopolysaccharide (clps) in human serum. serum clps was solubilized with detergent and then captured by lps-binding protein (lbp). l ... | 2006 | 16290027 |
| a randomized trial in patients undergoing percutaneous coronary angioplasty: roxithromycin does not reduce clinical restenosis but angioplasty increases antibody concentrations against chlamydia pneumoniae. | elevated antibodies against chlamydia pneumoniae have been associated with coronary artery disease. in patients undergoing percutaneous coronary angioplasty, we therefore investigated the effect of roxithromycin on symptomatic restenosis and determined antichlamydial antibodies as well as inflammatory and immunological parameters. | 2005 | 16290983 |
| seroprevalence of igg antibodies to chlamydia pneumoniae and helicobacter pylori among coronary heart disease patients and normal individuals in south indian population. | in recent years, the role of infectious agents in the aetiology of atherosclerotic disease has come to the forefront. in the present study, seroprevalence (igg) of chlamydia pneumoniae and helicobacter pylori in patients with atherosclerotic coronary heart disease was compared to normal healthy adults. out of a total of 117 patients 101 had unstable angina (ua) and 16 had chronic stable angina (csa). c. pneumoniae seropositivity was found in 66% of patients with ua and 94% of csa patients. the c ... | 2004 | 16295450 |
| follicular cervicitis: a case report. | chronic follicular cervicitis (cfc) is a benign inflammatory condition which can be easily diagnosed with a fair degree of assurance on pap stained cervical smears, thus preventing the need for cervical biopsy. we report a case of cfc in a postmenopausal woman. | 2004 | 16295497 |
| chlamydia pneumoniae seropositivity in women with pre-eclampsia. | 2006 | 16298370 | |
| chlamydia pneumoniae: comparison with findings of mycoplasma pneumoniae and streptococcus pneumoniae at thin-section ct. | to retrospectively compare thin-section computed tomographic (ct) findings of chlamydia pneumoniae pneumonia with those of streptococcus pneumoniae pneumonia and mycoplasma pneumoniae pneumonia. | 2006 | 16304082 |
| chlamydia pneumoniae and mycoplasma pneumoniae pneumonia: comparison of clinical, epidemiological characteristics and laboratory profiles. | the purpose of our retrospective 3-year study was to analyse and compare clinical and epidemiological characteristics in hospitalized patients older than 6 years with community-acquired pneumonia (cap) caused by chlamydia pneumoniae (87 patients) and mycoplasma pneumoniae (147 patients). c. pneumoniae and m. pneumoniae infection was confirmed by serology. c. pneumoniae patients were older (42.12 vs. 24.64 years), and were less likely to have a cough, rhinitis, and hoarseness (p<0.001). c. pneumo ... | 2006 | 16316495 |
| chlamydia pneumoniae alters mildly oxidized low-density lipoprotein-induced cell death in human endothelial cells, leading to necrosis rather than apoptosis. | atherosclerosis is characterized by oxidative stress that induces lipid and protein oxidation in the vascular wall. oxidized low-density lipoproteins (oxldls) are present in lesions, and one of their actions is to induce apoptosis or necrosis in vascular cells. a role for chlamydia pneumoniae in atherosclerosis has been proposed, but the mechanisms involved remain largely unknown. | 2006 | 16323142 |
| is seropositivity enough to show the association between coronary artery disease and chlamydia pneumoniae and helicobacter pylori infection? | 2006 | 16325945 | |
| [organizing pneumonia--own experiences with clarithromycin treatment]. | organising pneumonia (op) is a rare syndrome that has been associated with a variety of underlying disorders, including infections, collagen vascular diseases, toxic fumes, cancer, drugs and radiotherapy. cryptogenic form is also observed. steroids are usually effective in the treatment of op, but other treatment regimens have been used as well. we present 5 women with op, age ranged 57-76 years (mean - 67 years). two of them were smokers and three were non-smokers. one patient was treated becau ... | 2004 | 16329349 |
| antibiotics active against chlamydia do not reduce the risk of myocardial infarction. | there is evidence that chlamydia pneumoniae (cp) is involved in the aetiology of myocardial infarction (mi). randomised trials do not support a beneficial effect of antibiotics in secondary prevention of mi, but the evidence for an effect on primary prevention is conflicting. we investigated if past use of antibiotics active against cp is associated with a decreased risk of developing mi. | 2006 | 16331522 |
| effect of nitric oxide on the growth of chlamydophila pneumoniae. | chlamydophila pneumoniae is an important human intracellular pathogen; however, the pathogenesis of c. pneumoniae infection is poorly understood and the immune control mechanism versus host cells is not completely known. the role of the nitric oxide (no) synthase pathway in inhibiting the ability of c. pneumoniae to infect macrophage j774 cells and the ability of no to damage isolated c. pneumoniae were investigated. exposure of infected cultures to recombinant murine gamma interferon (murifn-ga ... | 2005 | 16333333 |
| kawasaki disease. | kawasaki disease (kd) is the leading cause of acquired heart disease among children in developed nations. its incidence has risen in recent years and 20% of untreated patients develop coronary artery abnormalities. | 2005 | 16335284 |
| reliability of radiographic findings and the relation to etiologic agents in community-acquired pneumonia. | in a clinical setting the chest radiograph is the reference standard in establishing the diagnosis of community-acquired pneumonia (cap). this study aimed to assess interobserver reliability (ir) of radiographic findings and the relationship to different causative pathogens in cap. chest radiographs of 192 patients with pneumonia, obtained from a database, were reviewed by 2 radiologists and 1 respiratory physician without specific clinical information. main pattern of infiltrate, extent of pneu ... | 2006 | 16337367 |
| randomised placebo controlled multicentre trial to assess short term clarithromycin for patients with stable coronary heart disease: claricor trial. | to determine if the macrolide clarithromycin affects mortality and cardiovascular morbidity in patients with stable coronary heart disease. | 2006 | 16339220 |
| mechanisms of chlamydophila pneumoniae-mediated gm-csf release in human bronchial epithelial cells. | chlamydophila pneumoniae is an important respiratory pathogen. in this study we characterized c. pneumoniae strain tw183-mediated activation of human small airway epithelial cells (saec) and the bronchial epithelial cell line beas-2b and demonstrated time-dependent secretion of granulocyte macrophage colony-stimulating factor (gm-csf) upon stimulation. tw183 activated p38 mitogen-activated protein kinase (mapk) in epithelial cells. kinase inhibition by sb202190 blocked chlamydia-mediated gm-csf ... | 2006 | 16340003 |
| chronic chlamydia pneumoniae infection in patients with symptomatic atherothrombosis. | the aim of the present study was to search for an association between chronic chlamydia pneumoniae infection, indicated by elevated antibody titers against the pathogen, atherothrombosis and the occurrence of arterial ischemic events. | 2006 | 16352340 |
| [effect of therapy with antibiotics on lipid metabolism and antioxidant reserve of patients with ischemic heart disease during chlamydia pneumoniae infection]. | effect of therapy with azithromycin and doxycycline on lipid metabolism, processes of lipid peroxidation and state of antioxidant defense was studied in patients with ischemic heart disease with elevated titer of antibodies to chlamydia pneumonia. therapy with azithromycin (500 mg/day for 2 months) was associated with lowering of antibody titer, moderate improvement of lipid spectrum, marked decrease of activity of lipid peroxidation and augmentation of blood plasma antioxidant reserve. there we ... | 2005 | 16353050 |
| inflammation and atherosclerosis. | purpose: the aim of this article is to discuss the role of inflammation in atherosclerosis. summary: an initial chemical, mechanical or immunological insult induces endothelial dysfunction. this triggers a cascade of inflammatory reactions, in which monocytes, macrophages, t lymphocytes and vascular smooth muscle cells participate. leukocyte adhesion molecules, cytokines, growth factors and metalloproteinases participate in all stages of atherogenesis. almost all of the traditional risk factors ... | 2006 | 16359887 |
| [can meningoencephalitis be caused by chlamydiae pneumoniae?]. | meningoencephalitis attributed to chlamydiae pneumoniae has rarely been reported in the literature. | 2005 | 16365630 |
| the cd14 functional gene polymorphism -260 c>t is not involved in either the susceptibility to chlamydia trachomatis infection or the development of tubal pathology. | the functional polymorphism -260 c>t in the lps sensing tlr4 co-receptor cd14 gene enhances the transcriptional activity and results in a higher cd14 receptor density. individuals carrying the t/t genotype also have significantly higher serum levels of soluble cd14. the t allele of this polymorphism has recently been linked to chlamydia pneumoniae infection. we investigated the role of the cd14 -260 c>t polymorphism in the susceptibility to and severity (defined as subfertility and/or tubal path ... | 2005 | 16368002 |
| usefulness of sparfloxacin against chlamydia pneumoniae infection in patients with bronchial asthma. | the efficacy of sparfloxacin (spfx) for the control of bronchial asthma was evaluated in 26 patients with suspected chlamydia pneumoniae infection. patients were randomly allocated to receive spfx 200 mg/day (n = 14) or control treatment (n = 12) for 21 days. significant improvements in serum c-reactive protein levels, and significant decreases in peripheral eosinophil counts, serum eosinophil cationic protein (ecp) and sputum ecp were observed in the spfx-treated group at day 21. spfx-treated p ... | 2005 | 16372585 |
| markers of inflammation and infection influence the outcome of patients with baseline asymptomatic carotid lesions: a 5-year follow-up study. | it is still in debate whether the evaluation of markers of infection and inflammation may be of importance for cerebrovascular and cardiovascular prevention, and we aimed to investigate this field in a prospective 5-year clinical follow-up study in patients with early stages of atherosclerosis. | 2006 | 16373649 |
| the influence of age and gender on the population-based incidence of community-acquired pneumonia caused by different microbial pathogens. | to determine the population-based incidence of community-acquired pneumonia (cap) in adults and to assess the relative importance of age and gender on the incidence of infections caused by different microbial pathogens. | 2006 | 16375972 |
| chlamydia pneumoniae seropositivity and risk of developing coronary heart disease in western saudi arabia. | to estimate the seroprevalence of igg and iga antibodies against chlamydia pneumoniae (c. pneumoniae) among a sample of the saudi population, and to evaluate whether there is a relationship between seropositivity to chronic infection with c. pneumoniae and the manifestation of symptomatic coronary heart disease (chd). | 2005 | 16380774 |
| human metapneumovirus and community-acquired pneumonia in children. | human metapneumovirus (hmpv) was first recognized in the netherlands in 2001 from nasopharyngeal aspirate samples and was associated with respiratory tract illness in the pediatric population. this was the first report of metapneumovirus infections in community-acquired pneumonia in taiwan. | 2005 | 16382752 |
| a prospective etiologic study of community-acquired pneumonia in taiwan. | the treatment of community-acquired pneumonia (cap) is complicated by the growing threat of antimicrobial resistance and the tendency to rely on empirical therapy. this study investigated the etiologic agents of adult cap in taiwan and the susceptibility of streptococcus pneumoniae isolates from these patients. | 2005 | 16385374 |
| infection with chlamydia pneumoniae but not helicobacter pylori is related to elevated apolipoprotein b levels. | results of many studies show that apolipoprotein b (apo b) is a better marker of risk of vascular disease than other lipid markers including ldl and hdl-cholesterol and triglycerides. we investigated the association between two infectious agents: c. pneumoniae and h. pylori, known to have an atherogenic effect, and apo b, to evaluate the effects of chronic infections on apo b levels. | 2005 | 16385920 |
| chlamydia pneumoniae and mycoplasma pneumoniae. | mycoplasma pneumoniae infection occurs worldwide and is the most common cause of community-acquired pneumonia (cap) in 5- to 20-year-olds. the most reliable diagnostic test is the enzyme immunoassay, which allows immunoglobulin (ig)g and igm titration and presents 92% sensitivity and 95% specificity on paired samples. potentially active drugs are tetracyclines, macrolides, ketolides, lincosamides, streptogamines, chloramphenicol, and fluoroquinolones. chlamydia pneumoniae accounts for 6 to 20% o ... | 2005 | 16388430 |
| antibiotic therapy for coronary heart disease: the myth and the reality. | atherosclerosis is acknowledged as an active inflammatory and thrombotic disease, as opposed to simple degeneration. infection with microorganisms may contribute to this inflammation and hence the atherosclerotic process. the "infective" hypothesis--first proposed more than a century ago by virchow--has been revisited in recent years and has implicated numerous microorganisms as potential stimuli. the greatest body of evidence points to chlamydia pneumoniae, a respiratory pathogen, as the "culpr ... | 2005 | 16389410 |
| chlamydia pneumoniae infection enhances cellular proliferation and reduces steroid responsiveness of human peripheral blood mononuclear cells via a tumor necrosis factor-alpha-dependent pathway. | although epidemiological studies have found an association between chlamydia pneumoniae infection and severe asthma, the causality and underlying mechanism are largely unknown. we hypothesized that c. pneumoniae infection increases the proliferation and enhances the survival of immune and inflammatory cells, resulting in reduced responsiveness to corticosteroids and suggesting that the underlying mechanism is related to a tnf-alpha-dependent pathway. | 2005 | 16393329 |
| increased aortic intima-media thickness in 11-year-old healthy children with persistent chlamydia pneumoniae seropositivity. | the relationship between chlamydia pneumoniae (cpn) infection and arterial measures of preclinical atherosclerosis has remained controversial. because atherogenesis begins in early life, we examined whether carotid and aortic intima-media thickness (imt) and brachial artery endothelial function are associated with cpn seropositivity in children. | 2006 | 16397138 |
| lack of serum oligoclonal antibody responses to chlamydophila pneumoniae in multiple sclerosis. | 2006 | 16401902 | |
| antibiotic therapy for coronary heart disease: the myth and the reality. | atherosclerosis is acknowledged as an active inflammatory and thrombotic disease, as opposed to simple degeneration. infection with microorganisms may contribute to this inflammation and hence the atherosclerotic process. the "infective" hypothesis - first proposed more than a century ago by virchow - has been revisited in recent years and has implicated numerous microorganisms as potential stimuli. the greatest body of evidence points to chlamydia pneumoniae, a respiratory pathogen, as the "cul ... | 2006 | 16404482 |
| detection of chlamydia pneumoniae in atherosclerotic tissue: a comparative study of pcr and immunocytochemistry. | the reported prevalence of chlamydia pneumoniae in atherosclerotic tissue appears to depend on the detection system used. this introduces problems in determining the role of c. pneumoniae in atherosclerosis. this study analyses the sensitivity and performance of molecular diagnostic methods for the detection of c. pneumoniae and polymerase chain reaction (pcr) inhibitors in atheromatous tissue. atherosclerotic tissue taken from 30 coronary endarterectomies, nine coronary arteries from explanted ... | 2005 | 16411373 |
| inhibitory effect of dietary phenolic compounds on chlamydia pneumoniae in cell cultures. | chlamydial infections are very common worldwide. all chlamydial species have a tendency to cause persistent infections, which have been associated to several chronic diseases including blinding trachoma, infertility and coronary heart disease (chd). at present, no efficient treatment for the eradication of chronic chlamydial infections exists and, thus, new antichlamydial compounds are urgently needed. this study was designed to screen antichlamydial activity of natural flavonoids and other natu ... | 2006 | 16414027 |
| chronic inflammation, immune response, and infection in abdominal aortic aneurysms. | abdominal aortic aneurysms (aaa) are associated with atherosclerosis, transmural degenerative processes, neovascularization, decrease in content of vascular smooth muscle cells, and a chronic infiltration, mainly located in the outer aortic wall. the chronic infiltration consists mainly of macrophages, lymphocytes, and plasma cells. the dominant cells are th2 restricted cd3+ lymphocytes expressing interleukine 4, 5, 8, and 10, and tumor necrosis factor-alpha for regulation of the local immune re ... | 2006 | 16414293 |
| mycobacterium tuberculosis complex in atherosclerosis. | in recent years, the results of some studies have revealed the possible potential role of several infectious agents in the inflammatory mechanism of atherosclerosis. the detection of specific antibodies against microorganisms such as and as well as chlamydia pneumoniae and cytomegalovirus as well as antibodies directed to heat shock proteins in the sera of atherosclerotic patients and the presence of genomic material in atheromatous plaques all provide evidence supporting the presumptive role of ... | 2005 | 16418767 |
| seropositivity to chlamydia pneumoniae is associated with risk of first ischemic stroke. | serologic evidence of infection with chlamydia pneumoniae has been associated with cardiovascular disease, but its relationship with stroke risk remains uncertain. the objective of this study is to determine whether serological evidence of c pneumoniae infection is associated with risk of ischemic stroke. | 2006 | 16424371 |
| chlamydia pneumoniae, stroke, and serological associations: anything learned from the atherosclerosis-cardiovascular literature or do we have to start over again? | 2006 | 16424375 | |
| fate of chlamydophila pneumoniae in human monocyte-derived dendritic cells: long lasting infection. | earlier studies from this group demonstrated that chlamydophila pneumoniae co-localized with dendritic cells (dc) in temporal artery biopsies from patients with giant cell arteritis (gca). to investigate the interaction of dc with c. pneumoniae we employed an in vitro cell culture system of human monocyte derived dc. these dc were infected with c. pneumoniae and observed at regular time intervals up to 25 days post infection. chlamydiae were visualized inside dc by both confocal and electron mic ... | 2006 | 16427247 |
| inflammation and chlamydia pneumoniae infection correlate with the severity of peripheral arterial disease. | our aim was to investigate the association of inflammation and chlamydia pneumoniae infection with the presence and severity of peripheral arterial disease. | 2006 | 16427340 |
| arginine-dependent gene regulation via the argr repressor is species specific in chlamydia. | some, but not all, chlamydia spp. are predicted to encode a homolog of argr, a master regulatory molecule that modulates arginine biosynthesis and catabolism in bacteria in response to intracellular arginine levels. while genes for arginine biosynthesis are apparently missing in chlamydia, a putative arginine transport system encoded by glnp, glnq, and artj is present. we found that recombinant chlamydia pneumoniae argr functions as an arginine-dependent aporepressor that bound specifically to o ... | 2006 | 16428395 |
| rapidly progressive glomerulonephritis in a patient with chlamydia pneumoniae infection: a possibility of superantigenic mechanism of its pathogenesis. | herein we describe a case of a patient with rapidly progressive glomerulonephritis after chlamydia pneumoniae infection. an 88-year-old woman who had had c. pneumoniae infection two months previously was admitted to our hospital with complaints of dyspnea and generalized edema. laboratory tests revealed acute renal failure, polyclonal hypergammaglobulinemia, highly increased level of c-reactive protein, and hematoproteinuria. a renal biopsy revealed mesangial and endocapillary proliferative glom ... | 2006 | 16429842 |
| [detection of chlamydia pneumoniae in human aortic tissue: kdta gene amplification and in vitro hybridization]. | atherosclerosis is the main cause of coronary and cerebrovascular disease which, in turn, are the most common causes of mortality and morbidity in the western world. recent publications suggest that infective microorganisms may play an important role in the genesis and progression of atherosclerosis. according to seroepidemiological and direct detection reports, chlamydia pneumoniae is the most plausible candidate. nevertheless, the mechanisms by which the microorganism induces its pathological ... | 2005 | 16433177 |
| mouse model of respiratory chlamydia pneumoniae infection for a genomic screen of subunit vaccine candidates. | an inbred a/j mouse respiratory challenge model was validated for vaccine testing against chlamydia (c.) pneumoniae and used to screen the c. pneumoniae genome for vaccine candidates by expression library immunization (eli). biolistic delivery of genetic vaccine constructs elicited th2-like immunity that was associated with inefficient elimination of c. pneumoniae. delivery by injection elicited protective th1-like responses. since biolistic delivery of pools of orfs was used in first round scre ... | 2006 | 16434129 |
| rifalazil pretreatment of mammalian cell cultures prevents subsequent chlamydia infection. | chlamydia species are widely disseminated obligate intracellular pathogens that primarily cause urogenital, ocular, and respiratory infections. in these studies, we show that exposing mammalian cells to antibacterial agents prior to chlamydia inoculation protects the host cells against subsequent challenge by chlamydiae (the protective effect [pe]). rifalazil exhibited a considerably stronger pe than did azithromycin, rifampin, doxycycline, and ofloxacin. specifically, 0.002 microg/ml rifalazil ... | 2006 | 16436694 |
| role of inflammation and infection in vascular disease. | relationship of infection, inflammation, and atherosclerosis has been a subject of intensive investigation in recent years. potential mechanisms whereby chronic infections may play a role in atherogenesis are myriad. chlamydia pneumoniae (cp) infection in early life may accelerate atherosclerosis, leading to cardiovascular complications. other infections, simultaneously occurring with cp, may result in a synergistic effect to promote atherosclerosis. chronic helicobacter pylori infection is know ... | 2005 | 16438065 |
| prevalence and persistence of antibodies to herpes viruses, chlamydia pneumoniae and helicobacter pylori in alaskan eskimos: the gocadan study. | the prevalence and persistence of antibodies against cytomegalovirus (cmv), herpes simplex virus types 1 (hsv1) and 2 (hsv2), helicobacter pylori and chlamydia pneumoniae were determined in alaskan eskimos. the study included 610 individuals (mean age 43 +/- 15 years; 45% males) participating in the genetics of coronary artery disease in alaska natives (gocadan) study. archived serum samples and those collected during the gocadan study were analysed for antibodies against the above pathogens by ... | 2006 | 16441448 |
| seroepidemiological studies of chlamydia pneumoniae infections in 1-36 months old children with respiratory tract infections and other diseases in poland. | presence of specific igm, igg and iga antibodies against chlamydia pneumoniae was evaluated in children aged 1 week to 36 months to investigate the role of c. pneumoniae in respiratory infections and other diseases. serum samples were obtained from 150 hospitalized children, including 123 children presenting the clinical symptoms of various respiratory tract infections, two children with acute diarrhoea, two children with meningitis, 14 children with urinary tract infection, and 9 children with ... | 2005 | 16450837 |
| etiologic diagnosis of adult bacterial pneumonia by culture and pcr applied to respiratory tract samples. | respiratory culture and multiplex pcr for streptococcus pneumoniae, haemophilus influenzae, mycoplasma pneumoniae, and chlamydophila pneumoniae were applied to sputum, nasopharyngeal swabs, and nasopharyngeal aspirates from 235 adult patients with community-acquired pneumonia and 113 controls. both culture and multiplex pcr performed well with the different samples and appear to be useful as diagnostic tools. | 2006 | 16455935 |
| 60-kda heat shock protein of chlamydia pneumoniae promotes a t helper type 1 immune response through il-12/il-23 production in monocyte-derived dendritic cells. | infection, in particular by chlamydia pneumoniae (cp), has been associated with atherosclerosis and coronary heart disease. immune reactions to heat shock proteins (hsps) have been advocated to link infection to atherosclerosis and its acute sequelae based on molecular mimicry with host hsps. we have here evaluated the role played by recombinant cp-hsp60 and cp-hsp10 for their ability to induce maturation of human monocyte-derived dendritic cells (mddc) and t cell polarization. cp-hsp60, but not ... | 2006 | 16460983 |
| the effect of infections and vaccinations on stroke risk. | there is increasing evidence that, in addition to conventional risk factors, acute and chronic infectious diseases increase the risk of stroke. acute infection, mainly respiratory, and both bacterial and viral infection, represent temporarily active trigger factors for cerebral ischemia. chronic infectious diseases that may increase the risk of stroke include periodontitis, chronic bronchitis and infections with microbial antigens, such as helicobacter pylori and chlamydia pneumoniae. from obser ... | 2006 | 16466297 |
| gene expression profiles of u937 human macrophages exposed to chlamydophila pneumoniae and/or low density lipoprotein in five study models using differential display and real-time rt-pcr. | many studies on atherosclerosis have indicated an association with chlamydophila pneumoniae, a respiratory intracellular pathogen that can infect bronchoalveolar macrophages, and be transported to sites of vascular injury. furthermore, the connection between low density lipoprotein (ldl), macrophages, foam cell formation, and atherosclerosis is well established. five study models were designed to mimic the early events in plaque formation, i.e. untreated u937 human macrophages as control; macrop ... | 2006 | 16466844 |
| chronic chlamydia pneumoniae infection and stroke in cameroon: a case-control study. | to determine the relationship between chronic chlamydia pneumoniae infection and stroke in cameroon. | 2006 | 16469962 |
| risk of ruling out severe acute respiratory syndrome by ruling in another diagnosis: variable incidence of atypical bacteria coinfection based on diagnostic assays. | severe acute respiratory syndrome (sars) caused the first epidemic of the 21st century and continues to threaten the global community. | 2006 | 16470249 |
| detection of chlamydia in the peripheral blood cells of normal donors using in vitro culture, immunofluorescence microscopy and flow cytometry techniques. | chlamydia trachomatis (ct) and chlamydia pneumoniae (cp) are medically significant infectious agents associated with various chronic human pathologies. nevertheless, specific roles in disease progression or initiation are incompletely defined. both pathogens infect established cell lines in vitro and polymerase chain reaction (pcr) has detected chlamydia dna in various clinical specimens as well as in normal donor peripheral blood monocytes (pbmc). however, chlamydia infection of other blood cel ... | 2006 | 16472397 |
| [antibodies to chlamydia pneumoniae in blood serum of patients with ischemic heart disease and presence of complicated lesions in coronary arteries]. | levels of igm, igg and iga antibodies to chlamydia pneumoniae were measured in 107 patients (age 33-75 years) with documented coronary atherosclerosis and 39 subjects with intact coronary arteries. rates of seropositivity to c. pneumoniae were 77.6 and 25.6% in patients and "healthy" subjects, respectively (p<0.05). seropositive (n=83) compared with seronegative (n=24) patients had higher prevalence of complicated lesions (p<0.05). | 2006 | 16474303 |
| do common infections cause stroke? | infections have long been recognized as a potential, if uncommon, cause of cerebrovascular disease. in recent years, with the growing recognition of the importance of inflammation in atherosclerosis, there has been renewed interest in the possibility that common infections may participate in the atherosclerotic process or lead to stroke through other mechanisms. specific organisms that have been implicated include chlamydia pneumoniae, herpes viruses, human immunodeficiency virus, helicobacter p ... | 2006 | 16479447 |
| [bacteriological profile of infectious endocarditis in the area of sfax (tunisia)]. | we performed a study to analyze epidemiological characteristics and bacteriological profile of infectious endocarditis (i.e) in the area of sfax (tunisia). we analyzed, retrospectively, all cases of i.e, according to duke criteria, hospitalized in the chu hédi chaker of sfax between january 1997 and december 2000. bacteriological investigation included blood culture, cardiac valve culture and serology. seventy-two cases of i.e were diagnosed. the average of age was 32.3 years. 47.3% of the patie ... | 2006 | 16479886 |
| development of a rapid real-time pcr assay for detection and quantification of four familiar species of chlamydiaceae. | chlamydiae are one of the causative agents of various diseases in animals and human beings, which include abortion, pneumonia, gastroenteritis, encephalomyelitis, conjunctivitis, arthritis and sexually transmitted diseases. much work has been carried out to attempt to develop an efficient pathogen detection strategy. here, we presented a chlamydiaceae-specific 23s rrna-based real-time pcr assay for simultaneous detection and quantification of four members of chlamydiaceae family, c. trachomatis, ... | 2006 | 16488188 |