Publications

the or nurse manager. blending an autocratic and democratic approach to lead effectively.		1999	2326857
nih 'research risks office' reprimands hospital institutional review board.		2008	2329621
contempo '90.		2008	2329645
tibenelast, 5,6-diethoxybenzo(b)thiophene-2-carboxylic acid, sodium salt (ly186655), is an orally active anti-asthma compound in the guinea pig.	anaphylactic shock was induced in actively sensitized guinea pigs by free inhalation of a high dose of ovalbumin (10 mg/ml) aerosol. tibenelast (ly186655), 5,6-diethoxybenzo(b)-thiophene-2-carboxylic acid, sodium salt, proved to be a potent orally active compound against anaphylactic shock induced by high dose antigen aerosol. when a lower aerosol challenge (0.05 mg/ml) was employed, bronchoconstriction was observed with a concomitant increase in lung resistance (rl) and a fall in dynamic compli ...	1990	2329918
evaluation of children with possible appendicitis using technetium 99m leukocyte scan.	we evaluated the use of technetium 99m albumin colloid white blood cell (tac-wbc) scan in 33 children with possible appendicitis. ten children had appendicitis, four of whom had perforated their appendix at the time of surgery. children with appendicitis differed from children without appendicitis in the incidence of right lower quadrant rebound tenderness (60% vs 17.4%), and white blood cell count (x10(3)/mm3) (14.0 + 1.9 vs 10.7 +/- 1.0). tac-wbc scans were interpreted as either positive, nega ...	2008	2330248
fine needle aspiration cytology of talc granulomatosis in a peripheral lymph node in a case of suspected intravenous drug abuse.	a fine needle aspiration (fna) specimen of an epitrochlear lymph node from a 22-year-old suspected intravenous drug abuser was submitted for cytologic examination, which revealed numerous granulomatous tissue fragments, histiocytes, lymphocytes and giant cells. polarizing microscopy revealed strongly birefringent material of varying shapes and sizes, including anisotropic crystals with the maltese cross configuration characteristic of starch. a cytologic diagnosis of talc granulomatosis in the l ...	2008	2343689
busulfan and veno-occlusive disease of the liver.		2008	2344115
therapeutic value of gramurin (oxolinic acid) in shigella infections and shigella-negative dysentery syndrome.	a total of 10 shigella-positive and 10 shigella-negative dysentery syndrome patients were treated with daily 2-g gramurin doses for 3 days. favourable clinical results could be obtained in response to the therapy. the complaints of the patients ceased within 48 hours. bacterial negativity was recorded on days 3, 4, and 5 after cessation of therapy in shigella flexneri-positive cases (5 cases), while in case of shigella sonnei positivity bacterium negativity could be obtained within the abovement ...	1990	2345905
epidemiology of bacterial pathogens associated with infectious diarrhea in djibouti.	during a survey examining the causes of diarrhea in the east african country of djibouti, 140 bacterial pathogens were recovered from 209 diarrheal and 100 control stools. the following pathogens were isolated at comparable frequencies from both diarrheal and control stools: enteroadherent escherichia coli (eaec) (10.6 versus 13%), enterotoxigenic e. coli (etec) (11 versus 10%), enteropathogenic e. coli (epec) (7.7 versus 12%), salmonella spp. (2.9 versus 3%), and campylobacter jejuni-c. coli (3 ...	1990	2351738
white cell counting in red cells and platelets: how few can we count?		2007	2360229
infant development.		2005	2366208
schwartz-jampel syndrome: i. clinical, electromyographic, and histologic studies.	in a new, typical case of schwartz-jampel syndrome (sjs) the origin of the disorder was found to be purely myogenic. concentric needle emg showed abundant and persistent spontaneous activity, maximal at insertion, and uninfluenced by local curarization. single-fiber emg showed rather stable, sometimes intermittent, discharge series with occasional amplitude and/or frequency fluctuations. it could be demonstrated that this activity did not consist of complex repetitive discharges, but of independ ...	1999	2366824
professional liability--a no-fault solution.		2008	2366845
role of bacterial and host factors in the pathogenesis of shigella septicemia.	to determine the role of bacterial and host factors in the pathogenesis of shigellemia, blood and fecal shigella isolates were compared for serum resistance and siderophore production, and shigellemic patients were examined for decreased serum bactericidal activity or increased serum transferrin saturation compared to control patients with non-bacteremic shigellosis. the majority of both blood (36/38) and fecal (36/48) shigella isolates were sensitive to normal serum (greater than 2 log kill/60 ...	1990	2373088
alterations of cellular characteristics of a human ovarian teratocarcinoma cell line after in vitro treatment with retinoids.	differentiation of the human teratocarcinoma derived cell line. pa-1, with retinoids was examined at concentrations (10(-6)-10(-8) m) that did not exhibit an antiproliferative effect during log-phase growth. treatment with naturally occurring retinoic acid or certain synthetic retinoids (13-cis retinoic acid, ro10-9359, and ro13-7410), while not significantly altering the log-phase growth rate, decreased the saturation cell density and mitotic indices after confluence. retinoid treatment also in ...	1990	2373285
[diagnostic criteria for acute t-cell type lymphoblastic leukemia].		2008	2373345
the staple.		2008	2373844
[the introduction of nursing information systems].		2001	2374027
tissue integration of a12o3-ceramic dental implants (frialit)--a case report.	the tissue intraosseous integration of a12o3-ceramic dental implants (frialit) is studied in a patient case, where an implant-fracture made it necessary to remove the implant from a patient's jaw. the surgical removing of the apical part of the implant with the use of a trepan bur made it possible to examine and visualize histologically and microradiographically the tissue adjacent to the implant. the results of both the histological and microradiographical studies showed that a good healing and ...	2007	2374995
[health care of immigrants].		2007	2375023
[working conditions and various indicators of morbidity with temporary disability of workers at the petroleum-processing plant].		2006	2384231
[working conditions and various indicators of morbidity with temporary disability of workers at the petroleum-processing plant].		2006	2384231
[the nice dental school: small but well integrated].		2008	2387186
effect of neuromuscular blockade on fetal oxidative metabolism.	because fetal neuromuscular blockade has been used during cord blood sampling procedures to prevent fetal movement, we studied the effect of pancuronium bromide on fetal arterial concentrations of glucose, lactate, and oxygen and their umbilical uptake in 6 chronically prepared fetal sheep. we observed a significant increase in the arterial concentrations and decrease in the umbilical uptakes. we suggest that cord blood sampling procedures for fetal assessment of oxidative metabolism not be perf ...	1990	2390540
morphologic characterization of osteoblast-like cell cultures isolated from newborn rat calvaria.	two methods for harvesting osteoblast-like cell populations from newborn (10 days) rat calvaria were compared. the first one consisted in culturing the periosteum-free bones and then trypsinizing the cells on the bone surface. the second one involved the migration of the osteoblasts on glass fragments before trypsinization. since the plating efficiency, the proportion of alkaline phosphatase-positive cells, the population doubling time, and the calcium deposition were more adequate, the second m ...	1990	2390733
locked in state. a clinicopathological study.	two patients developed the locked-in state characterised by quadriplegia and mutism with an alert sensorium. initially they had mild dysarthria and uncrossed hemisensory or hemimotor deficits involving the face and ipsilateral extremities. both patients died. rostral brainstem infarctions were found at autopsy in them. acute onset of uncrossed hemisensory and hemimotor deficits with dysarthria may be caused by infarction of the pons which may predispose to locked-in state.	2007	2391307
effects of surface tension and viscosity on airway reopening.	we studied airway opening in a benchtop model intended to mimic bronchial walls held in apposition by airway lining fluid. we measured the relationship between the airway opening velocity (u) and the applied airway opening pressure in thin-walled polyethylene tubes of different radii (r) using lining fluids of different surface tensions (gamma) and viscosities (mu). axial wall tension (t) was applied to modify the apparent wall compliance characteristics, and the lining film thickness (h) was va ...	2008	2394665
phosphorylation of the virg protein of agrobacterium tumefaciens by the autophosphorylated vira protein: essential role in biological activity of virg.	agrobacterium tumefaciens virulence genes are induced by plant signals through the vira-virg two-component regulatory system. the vira protein is a membrane-spanning sensor molecule that possesses an autophosphorylating activity, and the virg protein is a sequence-specific dna-binding protein. in this report, we demonstrate that the virg protein is phosphorylated by the vira protein and that the phosphate is directly transferred from the phosphorylated vira molecule (phosphohistidine) to the vir ...	1990	2394678
tertiary structure of oxidized flavodoxin from an eukaryotic red alga chondrus crispus at 2.35-a resolution. localization of charged residues and implication for interaction with electron transfer partners.	the crystal structure of the oxidized form of a flavodoxin from an eukaryotic red alga, chondrus crispus, has been determined by multiple isomorphous replacement and anomalous scattering methods. a model of the 173 residues and flavin mononucleotide (fmn) has been refined by a restrained least squares method to a crystallographic r-factor of 22.6% using 6236 reflections between 6.0 and 2.35 a with f greater than 3 sigma f. this molecule has a sheet consisting of five parallel beta-strands with t ...	1990	2394748
role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin d3-induced hl-60 cell differentiation.	the treatment of hl-60 myelocytic leukemia cells with 1 alpha,25-dihydroxyvitamin d3 (1,25-(oh)2d3) resulted in the activation of a neutral sphingomyelinase and in sphingomyelin turnover (okazaki, t., bell, r., and hannun, y. (1989) j. biol. chem. 264, 19076-19080). in this paper, the effects of 1,25-(oh)2d3 on the product of sphingomyelin hydrolysis, ceramide, and the possible function of ceramide as a lipid mediator of the effects of 1,25-(oh)2d3 on hl-60 cell differentiation were investigated ...	2007	2394750
onset of the hormone-sensitive perinatal period for sexual differentiation of the sexually dimorphic nucleus of the preoptic area in female rats.	the volume of the sexually dimorphic nucleus of the preoptic area (sdn-poa) of the rat brain is severalfold larger in males than in females. the volume of the sdn-poa can be influenced significantly by the hormonal milieu during the perinatal "critical period" of sexual differentiation of the brain. the purpose of the present study was to determine the onset of this period of sexual differentiation of the sdn-poa. pregnant rats received no treatment or were injected subcutaneously with oil on da ...	1990	2394991
effects of castration and testosterone treatment on the activity of testosterone-metabolizing enzymes in the brain of male and female zebra finches.	recently, we described the distribution of testosterone-metabolizing enzymes (i.e., aromatase, 5 alpha- and 5 beta-reductases) in the zebra finch (taeniopygia guttata) brain using a sensitive radioenzyme assay combined to the palkovits punch method. a number of sex-differences in the activity of these enzymes were observed especially in nuclei of the song-control system. the hormonal controls of these differences have now been analyzed by gonadectomizing birds of both sexes and by giving them a ...	1990	2394994
quantitative hepatobiliary scintigraphy.		2008	2395013
comparison of nonsteroidal anti-inflammatory drugs, ibuprofen and flurbiprofen, with methylprednisolone and placebo for acute pain, swelling, and trismus.	pain, swelling, loss of function, and hyperthermia are acute postoperative sequelae of inflammation due to tissue injury during surgical procedures. pharmacologic strategies for minimizing the clinical manifestations of surgical trauma are often directed toward blocking the formation or inhibiting the effects of the biochemical mediators of acute inflammation. this study compared two nonsteroidal anti-inflammatory drugs (nsaids), flurbiprofen and ibuprofen, with a prototype glucocorticoid, methy ...	2008	2395047
effect of glycerol on the hemodynamics of acutely induced ischemic area in the cerebral cortex of cats.	the effect of glycerol on the hemodynamics of ischemic areas of the brain was examined. employing a photoelectric apparatus, the cbv (vol%), mean transit time of blood(s), and cbf (ml/100 g/min) in the cortex of the left ectosylvian gyrus were determined in 16 anesthetized cats before, at 1 hr, and at 2 hr after left mca occlusion. in 10 cats, 10% glycerol in 5% fructose saline was intravenously administered at a speed of 5 ml/kg/hr at 1 hr after mca occlusion. the other animals served as the co ...	1990	2396522
doxycycline prophylaxis for shigellosis.	the efficacy of oral doxycycline, 100 mg/d for 14 days, in reducing the incidence of shigellosis in newcomers to an area hyperendemic for the disease was examined in a double-blind, placebo-controlled trial. of 107 entrants, 100 completed the study; 50 received the drug and 50 received a placebo. diarrheal disease and associated symptoms were monitored for 8 weeks. starting on the 3rd day of the trial, an outbreak was observed, and shigella flexneri type 2a was isolated from 6 subjects. eight of ...	1990	2404480
contribution of superoxide dismutase and catalase activities to shigella flexneri pathogenesis.	a shigella flexneri serotype 5 strain deficient in the production of the iron-containing superoxide dismutase fesod (sodb) and a catalase-negative (katfg) s. flexneri serotype 5 strain were isolated. both strains were examined for increased sensitivity to oxygen stress by using assays involving killing by mouse peritoneal macrophages and human polymorphonuclear leukocytes as well as infection of rabbit ileal loops. the sodb mutant was extremely sensitive to killing by phagocytes when compared wi ...	1990	2404874
acute glomerulonephritis due to shigella flexneri dysentery with demonstration of a virulence protein of shigella in circulating immune complexes.		1990	2405072
[theoretical conformation analysis of tetrasaccharide-repeated links of the shigella flexneri o-antigenic polysaccharide].	theoretical conformational analysis of four tetrasaccharide repeating units of the shigella flexneri serogroup y polysaccharide has been carried out. interdependency of conformational states of neighbouring disaccharide units in the oligosaccharides has been investigated and conformational distribution of tetrasaccharides in solution calculated. taking into account the entropy of oligosaccharide chains is shown to lead to significant correction of the results.	1985	2408628
a heat-modifiable outer membrane protein carries an antigen specific for the species yersinia enterocolitica and yersinia pseudotuberculosis.	the outer membranes of gram-negative bacteria are considered to be of importance in host-bacteria interaction, in protective immunity, and occasionally in subclassification within a species. in this study, the outer membranes of several strains of yersinia enterocolitica and y. pseudotuberculosis were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (sds-page). it was found that the appearance of the major proteins depended on the temperature at which they were solubilized i ...	1985	2409152
[synthesis of oligosaccharide fragments of o-specific polysaccharides of shigella flexneri. iii. synthesis of the tetrasaccharide glc alpha 1-3rha alpha 1-2(glc alpha 1-3)rha alpha 1-ome and the pentasaccharide glcnac beta 1-2(glc alpha 1-3)rha alpha 1-2(glc alpha 1-3)rha alpha 1-ome].	two synthetic schemes to prepare the title branched tetrasaccharide and pentasaccharide are described. these oligosaccharides represent fragments of the o-antigenic polysaccharides of shigella flexneri serotype 5b.	1985	2412567
autoaggressive t lymphocyte lines recognizing the encephalitogenic region of myelin basic protein: in vitro selection from unprimed rat t lymphocyte populations.	autoimmune t lymphocyte lines have been established from unprimed normal rat lymph node cell populations. in a first, negative-selection round, spontaneously proliferating (smlr) t cells were eliminated by a pulse of budr followed by short wave light irradiation. in a second, positive-selection round, the smlr-depleted populations were confronted with mbp presented by syngeneic spleen adherent cells. reactive t cells were propagated until stable, permanent t lines were established. all lines wer ...	1985	2413113
[membrane activity of a cell-free filtrate of shigella flexneri 2a].	in the course of metabolism in shigella flexneri 2a strain there was noted secretion of a membrane-tropic factor into media. this factor increased the conductivity of bilayer lipid membranes causing formation of ionic channels in them. minimal conductivity of the channels was about 25 ps in 0.5 m nacl; at ph 7-8 the channels exhibited cation-anion selectivity. the calculated number of cation transfer (t+) was elevated with an increase in the channel amplitude, approaching 0.86. since the conduct ...	1985	2413620
[use of immunoenzyme analysis for evaluating the specificity of the antibody recognition of the antigenic determinants of streptococcus group a].	investigations carried out with the use of a celia system have revealed that antibodies in the sera of patients with primary erysipelas and antibodies in rabbit antiserum to the ribosomes of group a streptococcus specifically bind with adsorbed streptococcal ribosomes, recognizing the antigenic determinants of streptococcal ribosomes, which differ from those of individual gram-negative prokaryotes (escherichia coli, shigella sonnei, shigella flexneri, salmonella minnesota). the modified celia sy ...	1985	2413662
[immune response and immune tolerance to the o-antigen of shigella flexneri vi].	the method for the determination of the number of cells synthetizing antibodies to s. flexneri vi o-antigen in the spleen of mice has been developed. primary immune response to this antigen has been studied with the use of the new method. immune response to the optimum immunogenic dose of o-antigen has a manifest variable character. the intensity of primary immune response has been shown to rise with the increase of the dose of o-antigen from 0.004 to 50 micrograms. the preliminary injection of ...	1985	2413664
genetic determinants of virulence in shigella and dysenteric strains of escherichia coli: their involvement in the pathogenesis of dysentery.		1985	2414072
[specific antigens of the causative agents and their antibodies in the circulating immune complexes in acute dysentery].	the level of circulating immune complexes has been determined in 53 patients in the dynamics of the disease. for the first time circulating immune complexes have been found to contain shigella sonnei k-antigen and shigella flexneri o-antigen, as well as iga, igg and igm to shigella. shigella antigens can be detected from the first week of the disease, and their occurrence does not depend on the level of circulating complexes in patients blood serum.	1985	2414952
[effect of vitamins of the b group on the accumulation of complex antigens of dysentery bacteria in the process of deep cultivation].		1985	2416151
[comparative characteristics of antigenic conversion induced by shigella flexneri and escherichia coli 0129 phages].	the interaction of s. flexneri converting phages pe5, p90 and fv with e. coli antigenic variant o129, e. coli o129 converting phage vb with the above antigenic variant and with s. flexneri y-variant was studied. phage pe5 and phage vb were found to induce the conversion of o-antigen in e. coli antigenic variant 0129 and in s. flexneri y-variant with the detection of antigens v and 7,8. phages p90 and fv induced no conversion of o-antigen. changes in the antigenic properties of convertants were c ...	1985	2416154
anti-hla-b27 antibodies in sera from patients with gram-negative bacterial infections.	several forms of seronegative polyarthritis are strongly associated with hla-b27, and a number of microorganisms have been implicated in the etiology of these diseases. to explain the association between hla-b27 and arthritis initiated by infection with these organisms, it has been proposed that there is immunologic cross-reactivity between the b27 molecule and 1 or more microbial antigens, and that this cross-reactivity leads to tolerance to such infection and/or to the production of anti-hla-b ...	1986	2421739
[occlusive and nonocclusive mesenteric ischemia. anamnestic and clinical findings].		2008	2422844
[effect of levamisole immunocorrective therapy on the dynamics of infectious o-antigenemia and the clinical manifestations in dysentery patients].	the immunocorrecting agent levamisole decreases the duration of infectious o-antigenemia, determined in the o-aggregate hemagglutination test and in the enzyme immunoassay, essentially accelerates the progress of convalescence and considerably decreases the possibility of the prolonged relapsing course of the disease in comparison with common methods of treatment.	1986	2422855
the response of the lung to foreign compounds that produce free radicals.		1986	2423026
the interaction of myelin basic protein with tubulin and the inhibition of tubulin carboxypeptidase activity.	tubulin carboxypeptidase was found to be inhibited by myelin basic protein in a concentration dependent manner. the inhibition was produced by the interaction between myelin basic protein with the substrate. as a consequence of this interaction, turbid insoluble aggregates were formed at either 5 degrees or 37 degrees c. the turbidity increased by increasing the myelin basic protein concentration and it reached a plateau at a molar ratio of myelin basic protein to tubulin dimer of about 6. at pl ...	1986	2423083
mechanism of rna redistribution of the 17,000g postmitochondrial supernatant after incubation at 37 degrees c and its impact on other related biochemical investigations.	evidence for stripping of ribosomes from rer in the 17,000g pms of the liver of the cancer patient was obtained in the 1.35 m region which is the region between the ser and rer. rna/protein ratios for the ser, 1.35 m region, and rer of 0.001, 0.083, and 0.235, respectively, for this liver are consistent with the degranulation of rer compared with rna/protein ratios for ser and rer from normal livers of 0.025 +/- 0.003, and 0.35 + 0.030, respectively. a rna/protein ratio of 0.235 was obtained for ...	1986	2423101
monoclonal antibodies specific for shigella flexneri lipopolysaccharides: clones binding to type i and type iii:6,7,8 antigens, group 6 antigen, and a core epitope.	monoclonal antibodies against the shigella flexneri lipopolysaccharide (lps) were generated in two fusions by using the myeloma cell line sp2/0 as a fusion partner with spleen cells from balb/c mice immunized with s. flexneri serotypes 1b and 3a bacteria. the antibodies were characterized by immunoblotting, enzyme-linked immunosorbent assay (elisa), hemagglutination, and coagglutination. four different types of monoclonal antibodies were isolated: antibodies specific for the core antigen of the ...	1986	2424839
shigella flexneri o-antigen epitopes: chemical and immunochemical analyses reveal that epitopes of type iii and group 6 antigens are identical.	in the present investigation we studied the nature of a shigella flexneri o antigen, the type iii antigen. no structural entity has yet been attributed to this antigen. phenol-water-extracted lipopolysaccharides (lpss) from all s. flexneri serotypes possessing either group 6 antigen or both type iii antigen and group 6 antigen were subjected to de-o-acetylation by weak alkali treatment. two-dimensional nuclear magnetic resonance spectra of serotype 3a native lps and de-o-acetylated lps were comp ...	1986	2424840
[nbt-test stimulation of neutrophilic granulocytes by bacterial preparations in healthy persons].		1986	2425131
[prostatism. routine urography].		2008	2426824
therapeutic considerations in the podiatric care of ulcerations.	in this excellent article, dr. mccarthy presents some of the most current concepts in the treatment of lower extremity ulcerations. this common clinical finding is frequently frustrating and difficult to treat effectively. it also requires a high degree of suspicion as to the primary underlying cause and many hours of careful treatment and follow-up to prevent serious secondary complications, such as infection and gangrene. the emphasis on therapeutic approaches lends much useful information in ...	2008	2427183
changes in tonicity of perfusion medium cause prolonged opening of calcium channels of the rat chromaffin cells to evoke explosive secretion of catecholamines.	secretion of catecholamines (ca) from the isolated rat adrenal gland during and after perfusion with hypertonic krebs bicarbonate solution was studied. perfusion with hypertonic solution made by adding either 156 mm sodium chloride, choline chloride, arginine hydrochloride, sodium thiocyanate, or 312 mm sucrose had no effect on the spontaneous secretion of ca. the secretion evoked by splanchnic nerve stimulation (10 hz for 30 sec) and nicotine (2 micrograms) remained unaffected during perfusion ...	1986	2427669
human p85 glycoprotein bears three distinct epitopes defined by several monoclonal antibodies.	a glycoprotein of apparent mol. wt 85,000 isolated from human cells of b lineage by affinity to 50b4-igg immunoadsorbent was shown previously to express two spatially distinct epitopes identified with monoclonal antibodies 50b4 and 50e6 [letarte et al. (1985) molec. immun. 22, 113-124]. it is now demonstrated that the p85 glycoprotein is homologous to the f10-44-2 antigen, defined initially as a t-lymphocyte-granulocyte-brain antigen [dalchau et al. (1980) eur. j. immun. 10, 745-749], the a1g3 h ...	1986	2427941
hla-b27m1m2 and high immune responsiveness to shigella flexneri in post-dysenteric arthritis.	the heterogeneous hla-b27 antigen is closely associated with post-infectious or reactive arthritis (rea) and is comprised of two serologically defined variants: b27m1+m2+ and b27m1+m2-. an outbreak of dysentery (n = 120) caused by a shigella flexneri 2a strain, which possessed cell envelope antigens with epitopes resembling b27m2, resulted in five b27m1+m2+ patients with rea. the remaining seven b27m1+m2+, one b27m1+m2- and all but three b27-negative patients remained free of joint symptoms; the ...	1986	2428743
colonization, virulence, and mucosal interaction of an enteropathogenic escherichia coli (strain rdec-1) expressing shigella somatic antigen in the rabbit intestine.	the group factor 3,4 somatic antigen was transferred by recombination from a donor strain of shigella flexneri type 2a to the escherichia coli o15 rabbit pathogen strain rdec-1. a hybrid clone (7482-1-1) that expressed only the s. flexneri 3,4 somatic antigen and a second clone (7482-1-7) from the same mating mixture that expressed only the o15 somatic antigen were compared for virulence in rabbits. the 7482-1-1 strain produced diarrhea in 10% of rabbits versus 84% for the 7482-1-7 strain (p les ...	1986	2430026
induction in rats of lysine imbalance by dietary homoarginine.	the use of dietary homoarginine (ha) to produce a lysine imbalance was examined in young rats. ha, a basic amino acid analogue, was shown earlier to compete with lysine for transport across the blood-brain barrier. feeding a diet limiting in lysine and containing ha reduced food intake and growth; increasing dietary lysine content lessened these effects. a 3-fold increase in dietary lysine caused 10, 4, 20 and 50-fold increases in lysine concentrations in plasma, brain, liver and muscle, respect ...	1986	2430077
[a questionnaire study. how and where are the patients with ventricular cancer operated?].		2008	2430149
an activated harvey ras oncogene produces benign tumours on mouse epidermal tissue.	studies of the mutagenic action required for specific chemicals to produce benign or malignant tumours suggest that in mouse skin at least two genetic events occur before carcinoma formation. the isolation of an activated form of the c-rash gene from skin papillomas has provided evidence that this gene may be a target for the first mutation, which could constitute the initiating mutation in skin carcinogenesis. in vitro studies indicate that the v-rash gene of harvey murine sarcoma virus (ha-msv ...	1986	2430189
t lymphocytes from hemophiliacs proliferate after exposure to factor viii product.	chronic exposure of hemophiliacs to allogeneic proteins via factor viii concentrate for control of bleeding could lead to a state of chronic antigen stimulation. immune function from eight hemophiliacs requiring large amounts of factor viii concentrate was assessed. it was found that 5 of 8 had a positive blastogenic response to low concentrations of factor viii in a 7-day thymidine uptake assay. separation of lymphocyte subpopulations indicated that the reactivity was contained in the t cell-en ...	2008	2430365
[synthesis of a repeating unit and the dimer of the repeating unit of the major chain of shigella flexneri o-antigen polysaccharide].	methyl glycoside of the tetrasaccharide glcnac(beta 1-2)rha(alpha 1-2)rha(alpha 1-3)rha, which represents a repeating unit of the basic chain of shigella flexneri o-antigenic polysaccharides, was synthesized using acylated monosaccharide synthons. a dimer of the repeating unit, octasaccharide [glcnac(beta 1-2)rha(alpha 1-2) rha(alpha 1-3)rha(alpha 1-3)]2-ome was obtained by trclo4-catalyzed condensation of two tetrasaccharide blocks.	1986	2430581
lack of correlation between hla-b27 like antigenic epitopes on shigella flexneri and the occurrence of reactive arthritis.		1986	2430745
[intergeneric antigenic relation of hafnia and shigella (s. flexneri and s. boydii) bacteria].	the o-antigenic relationships between hafnia and shigellae (s. flexneri and s. boydii) have been studied. for the first time the presence of antigenic relationship between hafnia o19, o4, o9, o33, o5, o16, o12, o7, o29, o28, o10, o32, o24, o25, o18, o1, o13, o3, o22, o30, o37, o14, o11, o25, o23, o21, o28, o16, o24, o8, o26, o27 and s. flexneri la, lb, 2a, 2b, 4a, 4b, 6, 5a, 5b, as well as between hafnia o10, o21, o35, o36, o9, o28, o8, o30 and s. boydii 1, 3, 6, 14, 2, 5, 2, 12 have been reveal ...	1986	2431565
combination chemotherapy of disseminated kaposi's sarcoma in patients with the acquired immune deficiency syndrome.	two clinical trials were conducted to assess the efficacy and safety of a combination chemotherapy regimen for the treatment of kaposi's sarcoma in patients with the acquired immune deficiency syndrome (aids). eighteen consecutive patients with disseminated kaposi's sarcoma were treated with a six-drug regimen of doxorubicin (adriamycin), vinblastine, bleomycin/actinomycin d, vincristine, dacarbazine (abv/adv). a brief partial or complete response was achieved in 13 patients. most patients died ...	2008	2435150
in situ hybridization methods for the detection of somatostatin mrna in tissue sections using antisense rna probes.	in situ hybridization studies with [32p] and [3h] labelled antisense rna probes were undertaken to determine optimal methods of tissue fixation, tissue sectioning, and conditions of hybridization, and to compare the relative merits of the two different radioactive labels. the distribution of somatostatin mrna in neurons of rat brain using a labelled antisense somatostatin rna probe was employed as a model for these studies. the highest degree of sensitivity for in situ hybridization was obtained ...	1986	2435682
monoclonal antibodies specific for shigella flexneri lipopolysaccharides: clones binding to type iv, v, and vi antigens, group 3,4 antigen, and an epitope common to all shigella flexneri and shigella dysenteriae type 1 stains.	monoclonal antibodies reactive with shigella flexneri o antigens were generated in both mouse and rat systems. antibody-producing hybridomas were screened in an enzyme-linked immunosorbent assay using chemically defined lipopolysaccharides as antigens, and the epitope specificities were determined with a panel of lipopolysaccharides and synthetic o-antigen-specific glycoconjugates as antigens. to verify the specificity seen in the enzyme-linked immunosorbent assay, the antibodies were used in ag ...	1987	2437036
[genetic characteristics and trends in the spread of a new shigella flexneri subserovar with the antigenic formula iv:7,8].	as the result of experiments with the conjugation of s. flexneri strains 4 belonging to an unusual subserovar (iv: 7,8) with escherichia coli donor strains k12 hfr c and hfr h, as well as experiments with converting phages iv and 7,8, this new subserovar of s. flexneri 4, similarly to other s. flexneri subserovars, was proved to be the y-variant of shigellae rendered lysogenic by the two above phages. the experiments also revealed that 97.9% of all s. flexneri strains 4 (iv: 7,8) under study pos ...	1987	2437740
the novel carbohydrate epitope l3 is shared by some neural cell adhesion molecules.	the monoclonal l3 antibody reacts with an n-glycosidically linked carbohydrate structure on at least nine glycoproteins of adult mouse brain. three out of the l3 epitope-carrying glycoproteins could be identified as the neural cell adhesion molecules l1 and myelin-associated glycoprotein, and the novel adhesion molecule on glia. expression of the l3 carbohydrate epitope is regulated independently of the protein backbone of these three glycoproteins. based on the observation that out of three fun ...	1987	2438289
characterization of five shigella flexneri variant y-specific monoclonal antibodies using defined saccharides and glycoconjugate antigens.	the structural domains of the shigella flexneri variant y o-antigen epitopes 3,4 have defied definition, despite knowledge of the structure of the linear polysaccharide chain of the lps molecule. the dual epitope designation of group antigen 3,4 is based on absorption data using polyvalent rabbit antisera. five monoclonal antibodies specific for the y antigen, generated after immunization of balb/c mice or lou/c rats, were selected on the basis of elisa by using well-characterized s. flexneri y ...	1987	2438343
structure and biology of shigella flexneri o antigens.		1987	2438412
increase of enkephalin and decrease of substance p immunoreactivity in the dorsal and ventral striatum of the rat after midbrain 6-hydroxydopamine lesions.	unilateral 6-hydroxydopamine lesions of the mesostriatal dopaminergic system in the rat resulted in a decrease of substance p-immunoreactivity in the ventral striatum, and in a heterogeneously distributed increase of enkephalin-immunoreactivity in the dorsal and ventral striatum and the globus pallidus. the respective decrease and increase are caused by a lower or higher staining intensity of the peptidergic fibers, whereas no changes were found in the cell bodies.	1987	2440523
methodology for high-resolution two-dimensional gel electrophoresis.		2008	2440530
[marked inhibition of transcription in mammalian cells by x-rays during disturbance of the topological continuity of superhelical dna loops].		2008	2440650
[enhancement of the therapeutic efficacy of blood substitutes in burn shock].		1987	2440759
a new set of monoclonal antibodies to human mhc class ii alpha chains demonstrates that most alpha epitopes are inaccessible on the living cell surface.	when mice were immunized with a mixture of human mhc class ii alpha and beta glycoprotein chains, the predominant antibody response was anti-alpha, and from a subsequent fusion experiment over 60 hybridomas showing anti-alpha activity were generated, compared with 11 anti-beta secretors. these findings contrast with the relative paucity of anti-alpha monoclonals described previously. use of a miniaturized western blot screening protocol was a critical factor in the present study since the anti-a ...	1987	2440796
a new set of monoclonal antibodies to human mhc class ii alpha chains demonstrates that most alpha epitopes are inaccessible on the living cell surface.	when mice were immunized with a mixture of human mhc class ii alpha and beta glycoprotein chains, the predominant antibody response was anti-alpha, and from a subsequent fusion experiment over 60 hybridomas showing anti-alpha activity were generated, compared with 11 anti-beta secretors. these findings contrast with the relative paucity of anti-alpha monoclonals described previously. use of a miniaturized western blot screening protocol was a critical factor in the present study since the anti-a ...	1987	2440796
prostate-specific antigen. superior serum marker for prostatic carcinoma.		2008	2440830
[determination of serum antibody avidity compared to infectious o-antigenemia in paratyphoid b patients].	the avidity of serum antibodies depending on infectious o-antigenemia in patients with paratyphoid b has been studied in the course of the disease. the study has revealed a faintly pronounced inverse correlation between the degree of avidity of serum antibodies and the level of infectious antigenemia. the avidity of serum antibodies in paratyphoid b has been found to increase in the course of the disease. a significant dependence of the severity of the disease on the avidity of serum antibodies ...	1987	2441547
[nonspecific and antigen-specific adhesiveness of circulating lymphocytes in dysentery patients undergoing combined therapy using thymalin and indomethacin].	nonspecific adhesiveness of lymphocytes to polyacrylonitrile fiber and the antigen-specific adhesiveness of t-lymphocytes to shigella flexneri pellicular immunosorbent have been studied in dysentery patients. short courses of treatment with indomethacin, but not with thymalin (the preparation of thymic hormones), used for immunomodulation, have accelerated the normalization of nonspecific lymphocyte adhesiveness during regression of the disease, while indomethacin, in contrast to thymalin, inhib ...	1987	2441548
lactase insufficiency in chinese children detected by oral milk and lactose challenge.	a study to determine the incidence of late-onset lactose intolerance was undertaken in 68 normal chinese children in singapore using measurements of breath hydrogen concentrations, following a lactose or milk challenge, as indicator of lactose malabsorption. evidence of lactose malabsorption was detected in 26% of children given a lactose challenge, and in 21% of those given a milk challenge. it is concluded that late-onset lactase insufficiency is common in chinese children in singapore.	2005	2441643
discrimination of hepatocyte-stimulating activity from human recombinant tumor necrosis factor alpha.	the involvement of tumor necrosis factor alpha (tnf alpha) in the regulation of acute-phase protein synthesis is currently under discussion. in this study the effect of human recombinant tnf alpha on the regulation of the 4 acute-phase proteins alpha 2-macroglobulin, albumin, alpha 1-proteinase inhibitor and alpha 1-acute-phase globulin was investigated in rat hepatocyte primary cultures. no changes in synthesis of any of the 4 proteins were observed. however, an acute-phase response similar to ...	1987	2441999
cystic neoplasms of the pancreas.	eight patients with cystic neoplasms of the pancreas were seen at four northern california hospitals between the years 1978 and 1986. three of the tumors were benign and five were malignant. three females, whose average age was 61 years, had cystadenomas. three females and two males, whose average age was 48 years, had mucinous cystadenocarcinomas. clinical presentations were similar among all patients. abdominal pain was a prominent feature. anorexia, weight loss, nausea and vomiting with a pal ...	2008	2446398
influence of neuropeptides on airway smooth muscle.	the first bronchoactive (and vasoactive) peptide to be discovered in the lung was isolated and characterized in 1970 from an embryologically related organ, the small intestine. since then, more than 20 additional peptides have been described in lung tissue and their biologic activities investigated. many of these are neuropeptides acting as neurotransmitters or neuromodulators to influence airway, pulmonary vascular, and other functions. more neuropeptides are known to exist in the brain and per ...	1987	2446543
acetylcholine receptor-specific human t-lymphocyte lines.		1987	2446551
definition of myasthenogenic sites of the human acetylcholine receptor using synthetic peptides.	experimental autoimmune myasthenia gravis (eamg) and antibodies that modulate achrs from cultured human muscle are induced by a disulfide-looped peptide comprising the human acetylcholine receptor (achr) alpha-subunit residues 125-147 (h alpha 125-147). to delineate the essential antigenic requirements for induction of eamg by this peptide, a series of peptides was synthesized: (a) a nonlooped analog (cys 128 replaced by ser) stimulated modulating autoantibodies, induced eamg, and bound antibodi ...	1987	2446556
cell transformation by the viral src oncogene.		2008	2446642
quantitative assessment of lung damage due to bleomycin using computed tomography.	visual assessment and density measurements of the lung using computed tomography (ct) were made in 18 patients undergoing treatment with bleomycin for malignant teratoma of the testis. the results of both visual assessment and density measurements were compared with changes in gas transfer per unit lung volume (kco). visual assessment of severity of damage to the lungs caused by bleomycin is unrelated to changes in kco but is characteristic of bleomycin damage and allows a confident diagnosis to ...	2008	2446690
distributions of certain neuropeptides in the primate thalamus.	the distributions of fibers and terminals immunoreactive for somatostatin (srif), neuropeptide y (npy), substance p (sp) and cholecystokinin octapeptide (cck), were studied in the diencephalon of cynomolgus monkeys. immunoreactivity for all 4 peptides is found in extrinsic afferent fibers innervating the dorsal thalamus, ventral thalamus and epithalamus. the distributions of such fibers are more extensive than previously described and include many relay nuclei in their zones of terminations. sp ...	1987	2446708
alpha-fetoprotein-producing renal cell carcinoma.	a case of alpha-fetoprotein (afp)-producing renal cell carcinoma with multiple bone and lung metastases, but without liver involvement is reported. the stain specific to afp (avidin-biotin complex) proved the presence of the afp in the cytoplasms of some cells of the renal tumors. in addition, three other cases of aff-producing renal cancer recently published in the literature in japan are reviewed. these four cases indicate that mesoderm-originating malignant tumors such as renal cell carcinoma ...	2008	2446735
heterogeneity in chromosome damage and repair rates after bleomycin in ataxia telangiectasia cells.	cells derived from patients with ataxia telangiectasia (at) are known to be exceptionally sensitive to ionizing radiation and chemotherapeutic agents such as bleomycin (blm), neocarzinostatin, and etoposide. this increased sensitivity is manifested by high chromosome aberration frequencies after treatment. in order to probe the underlying basis for this phenomenon, the technique of premature chromosome condensation was used to determine whether the increased chromosome damage observed after bleo ...	1988	2446745
ultraviolet-induced suppressor t cells and factor(s) in murine contact photosensitivity. i. biological and immunochemical characterization of factor(s) extracted from suppressor t cells.	murine contact photosensitivity (cps) to 3,3',4',5-tetrachlorosalicylanilide (tcsa) is a highly specific, t-cell-mediated delayed-type hypersensitivity (dth). preexposure of the photosensitizing site to low doses of ultraviolet b(uvb) rendered mice unresponsive to challenge reaction. this unresponsiveness was associated with the generation of antigen-specific, afferent limb-acting, lyt-1+2-,l3t4+ suppressor t cells (ts-cps) in the spleen, thymus, and lymph node. cell-free extract(s) obtained by ...	2008	2446779
cord serum gamma glutamyltransferase in newborns.	this article reports correlations among gamma-glutamyltransferase (ggt), fetal haemoglobin (fh), alpha-fetoprotein, 5'-nucleotidase, ceruloplasmin, and direct, indirect, and total bilirubin in the serum of blood taken from the umbilical cords of 128 newborns delivered after 37-42 weeks of gestation. ggt was significantly correlated with alpha-fetoprotein, but not with direct bilirubin, indirect bilirubin, total bilirubin, fh, or %fh. neither fh nor %fh were correlated with alpha-fetoprotein, but ...	2008	2446803