Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| direct construction of an open-sandwich enzyme immunoassay for one-step noncompetitive detection of thyroid hormone t4. | to establish a sensitive noncompetitive immunoassay for thyroxine (t4), we attempted to isolate anti-t4 antibodies from a phage display library based on a phagemid pdong1 ( dong et al. anal. biochem.2009, 36, 386 ), which was designed to enable open-sandwich enzyme-linked immunosorbent assay (os-elisa) after selection on immobilized antigen. after the fab-displaying phage library made from the splenocytes of t4-klh immunized mice was subjected to biopanning on t4-bsa, two t4-specific clones were ... | 2011 | 21214207 |
| location of si vacancies and [ti(osi)4] and [ti(osi)3oh] sites in the mfi framework: a large cluster and full ab initio study. | titanium silicalite-1 (ts-1) is an important catalyst for selective oxidation reactions. however, the nature and structure of the active sites and the mechanistic details of the catalytic reactions over ts-1 have not been well-understood, leaving a continuous debate on the genesis of active sites on the ts-1 surface in the literature. in this work, the location of si vacancies and [ti(osi)(4)] and [ti(osi)(3)oh] sites in the mfi (framework type code of zsm-5 (zeolite socony mobile-five)) framewo ... | 2011 | 21214280 |
| target localization and toxicity in dose-escalated prostate radiotherapy with image-guided approach using daily planar kilovoltage imaging. | dose escalation with intensity-modulated radiation therapy (imrt) for carcinoma of the prostate has augmented the need for accurate prostate localization prior to dose delivery. daily planar kilovoltage (kv) imaging is a low-dose image-guidance technique that is prevalent among radiation oncologists. however, clinical outcomes evaluating the benefit of daily kv imaging are lacking. the purpose of this study was to report our clinical experience, including prostate motion and gastrointestinal (gi ... | 2011 | 21214286 |
| l-thyroxine treatment in primary hypothyroidism does not increase the content of free triiodothyronine in cerebrospinal fluid: a pilot study. | the association between cerebrospinal fluid (csf) and serum concentration of thyroid hormones and pituitary thyrotropin stimulating hormone (tsh) was studied in nine hypothyroid patients (ht) before and in seven after l-thyroxine treatment. with l-thyroxine, median free t4 increased 4-fold in serum (3.5 pmol/l vs 17.5 pmol/l) and 3-fold in csf, (3.9 pmol/l vs 11.5 pmol/l). correspondingly, total t3 in serum increased two-fold (0.9 nmol/l vs 2.2 nmol/l). unexpectedly, free t3 concentration in csf ... | 2011 | 21214501 |
| [construction of bifidobacterium infantis/cd tumor targeting gene therapy system.] | background: to construct the bifidobacterium infantis/cd tumor targeting gene therapy system. methods: pcr expanded cd gene and pgex-1lambdat plasmid was transferred into e.coli. jm109. with tss solution. then a dual restriction enzyme (ecor i and bamh i) digestion was carried out to cut cd gene and pgex-1lambdat plasmid. two segments (4.9 kb and 1.3 kb) were selected and extracted from the gel. t4 dna ligase was added to these two segments' mixture. finally, reconstruction fragment was transfer ... | 2004 | 21214999 |
| [the heterogeneous nuclear ribonucleoprotein a2/b1 expression in non-small cell lung cancer and its clinical significance.] | background: to investigate the expression features of the heterogeneous nuclear ribonucleoprotein a2/b1 (hnrnp a2/b1) in non-small cell lung cancer and its clinical significance. methods: hnrnp a2/b1 expression of cancer tissues, paracancerous lung tissues, resected bronchial stump epithelium tissues was detected in 58 non-small cell lung cancer patients and pulmonary tissues in 30 patients with benigh pulmonary lesions as control by immunohistochemistry methods. results: the positive expressive ... | 2004 | 21215000 |
| [expression of cox-2 and its prognostic significance in non-small cell lung cancer.] | background: to investigate the expression of cox-2 and its relation to clinical pathophysiological features and prognosis in non-small cell lung cancer (nsclc). methods: the expression of cox-2 protein was detected in 52 nsclc tissues by immunohistochemical (s-p) method. results: the positive cox-2 expression was observed in 25 (48.1%) cases of nsclc tissues. the positive rate of cox-2 expression was 76.5% and 34.3% in adenocarcinoma and squamous cell carcinoma respectively (p < 0.01). the posit ... | 2004 | 21215004 |
| [total thyroidectomy: indications and complications]. | to investigate the indications and complications of the total thyroidectomy in the management of thyroid cancer. | 2010 | 21215203 |
| thyroid hormones modulate gaba(a) receptor-mediated currents in hippocampal neurons. | thyroid hormones (ths) play a crucial role in the maturation and functioning of mammalian central nervous system. thyroxine (t4) and 3, 3', 5-l-triiodothyronine (t3) are well known for their genomic effects, but recently attention has been focused on their non genomic actions as modulators of neuronal activity. in the present study we report that t4 and t3 reduce, in a non competitive manner, gaba-evoked currents in rat hippocampal cultures with ic₅₀s of 13±4μm and 12±3μm, respectively. the geno ... | 2011 | 21215272 |
| variation in mutation rates caused by rb69pol fidelity mutants can be rationalized on the basis of their kinetic behavior and crystal structures. | we have previously observed that stepwise replacement of amino acid residues in the nascent base-pair binding pocket of rb69 dna polymerase (rb69pol) with ala or gly expanded the space in this pocket, resulting in a progressive increase in misincorporation. however, in vivo results with similar rb69pol nascent base-pair binding pocket mutants showed that mutation rates, as determined by the t4 phage ri forward assay and rii reversion assay, were significantly lower for the rb69pol s565g/y567a do ... | 2011 | 21216248 |
| induction of reversible meiosis arrest of bovine oocytes using a two-step procedure under defined and nondefined conditions. | the objective was to study the effect of a defined culture system, on nuclear and cytoplasmic maturation of bovine oocytes, using the two-step procedure of ivm to detect possible inhibition and subsequent resumption of meiosis arrest. in the first step, called the prematuration period (pmp), cocs were cultured in t1-non-defined medium (ndm), or t2-defined medium (dm), both for 24 h. in step 2, called the resumption period (rp), cocs were cultured in: ndm (t1); dm + ndm (t3); or dm+dm (t4) for 24 ... | 2011 | 21220166 |
| incidental papillary thyroid carcinoma in a patient presenting with graves' hyperthyroidism and concomitant obstructive sequestered intrathoracic multinodular goiter. | a previously healthy 27-year-old woman presented with a thyroid goiter, symptoms of thyrotoxicosis, and mild respiratory obstruction. the serum thyroid stimulating hormone (tsh) was suppressed, serum t4 was elevated, and 24-hour radioiodine uptake was elevated at 59%. thyroid scintigraphy showed intense uptake in an enlarged gland, with a cold nodule on the right, and a large isolated mass in the mediastinum, with very mild uptake. total thyroidectomy and excision of the mediastinal mass reveale ... | 2011 | 21220984 |
| aggressive surgical approach for patients with t4 gastric carcinoma: promise or myth? | surgical outcomes of multiorgan resection (mor) for t4 gastric carcinoma reported in the literature are widely variable. we herein report a large surgical series of t4 gastric carcinoma. | 2011 | 21222167 |
| nerve-evoked constriction of rat tail veins is potentiated and venous diameter is reduced after chronic spinal cord transection. | despite reduced sympathetic activity below the level of a spinal cord injury (sci), venoconstriction during autonomic dysreflexia increases venous return to the heart. here, contractions of isometrically mounted tail veins from rats with spinal transection at t4 performed 8 - 10 weeks earlier are compared with those from sham-operated rats. after sci, lumen diameter was reduced by ∼30% and the contractions evoked by electrical stimulation of the perivascular axons were larger than control. this ... | 2011 | 21222499 |
| [distributions of primary nasopharyngeal carcinoma tumor and patterns of skull base erosion detected by magnetic resonance imaging]. | to evaluate the distributions of primary nasopharyngeal carcinoma (npc) and the patterns of skull base involvement in npc patients using magnetic resonance imaging (mri). | 2010 | 21223751 |
| neoadjuvant m-vac (methotrexate, vinblastine, adriamycin, and cisplatin) chemotherapy and bladder preservation for muscle-infiltrating transitional cell carcinoma of the bladder. | a group of 66 patients with locally advanced t2-t4 nomo tcc of the bladder were treated with three cycles of neo-adjuvant m-vac chemotherapy. of 65 evaluable patients, 18 (28%) were t2, 22 (34%) were t3a, 21 (33%) were t3b, and 4 (6%) were t4a. patients were restaged clinically by repeat ct scan and turb and were to undergo pathologic staging. partial cystectomy was to be performed in patients with initial monofocal lesions who responded to therapy. as the study evolved, many patients who respon ... | 1995 | 21224105 |
| [early prediction of treatment response by serum crp levels in patients with advanced esophageal cancer who underwent definitive chemoradiotherapy]. | serum crp has been shown to be associated with the progression of esophageal cancer. the purpose of this study was to examine the relationship between treatment response and serum crp levels in time course during definitive chemoradiotherapy (crt) in terms of early prediction of crt response by serum crp. the subjects of this study were 36 patients with ct3/ct4 esophageal squamous cell carcinoma who underwent definitive crt in our hospital. serum crp levels during definitive crt (pretreatment, 1 ... | 2010 | 21224533 |
| [a case of unresectable advanced gastric cancer successfully treated with chemotherapy after gastrojejunostomy]. | we report a patient with unresectable advanced gastric cancer who was successfully treated with chemotherapy after gastrojejunostomy. a 64-year-old man was admitted to our hospital complaining of appetite loss and body weight loss. abdominal enhanced ct revealed a gastric wall thickening and swelling of lymph nodes in the lesser curvature. upper gastrointestinal endoscopy showed a gastric cancer in the antrum of the stomach. he underwent laparotomy, which revealed a t4 tumor invading the pancrea ... | 2010 | 21224615 |
| the epiphyseal ring: a long forgotten anatomical structure with significant physiological function. | a descriptive study of the epiphyseal ring's structural design along the thoracolumbar spine. | 2011 | 21224766 |
| 3-t mri with phased-array surface coil in the local staging of rectal cancer. | this study sought to evaluate the diagnostic accuracy of surface-coil 3t magnetic resonance (mr) imaging in the preoperative study of patients with rectal cancer. | 2011 | 21225363 |
| the relationship between thyroid function and bone mineral density in euthyroid healthy subjects in taiwan. | it has been reported that low normal circulating thyrotropin (tsh) levels correlate with lower bone mineral density (bmd) in the korean postmenopausal female. the goal of this study is to evaluate this relationship in different sex and age groups in a chinese population. | 2011 | 21226562 |
| environmental procarcinogen hypothesis of bladder cancer in humans: dapsone hydroxylation as a susceptibility risk factor for aggressive bladder cancer. | the dapsone recovery ratio (dprr), which is determined after single oral dose administration of dapsone by measuring the parent drug and hydroxylated metabolite, provides an in vivo measure of the efficiency of the drug metabolizing enzymes responsible for this metabolic route, putatively cyp3a4. this affords the potential to evaluate the hypothesis that this drug metabolizing enzyme system is involved in the pathogenesis of human bladder cancer. the present study is a matched case-control compa ... | 1997 | 21227048 |
| risk factors for concomitant involvement of the female urethra at cystectomy for malignancy. | to examine the risk factors for urethral involvement in female patients after cystectomy for malignancy, a retrospective review of the records of 22 females treated with cystectomy for primary bladder malignancy were examined and analyzed with respect to presence of urethral involvement, tumor location, pathologic stage, tumor grade, lymph node status, and histologic cell type of the cancer. of the 22 patients studied, three (13.6%) had urethral involvement in the pathologic specimens. bladder n ... | 1997 | 21227144 |
| does a subcentimeter distal resection margin adversely influence oncologic outcomes in patients with rectal cancer undergoing restorative proctectomy? | a 1-cm distal clearance margin is recommended for mid/low rectal cancers. | 2011 | 21228662 |
| analytic modeling of tidal effects in the relativistic inspiral of binary neutron stars. | to detect the gravitational-wave (gw) signal from binary neutron stars and extract information about the equation of state of matter at nuclear density, it is necessary to match the signal with a bank of accurate templates. we present the two longest (to date) general-relativistic simulations of equal-mass binary neutron stars with different compactnesses, c=0.12 and c=0.14, and compare them with a tidal extension of the effective-one-body (eob) model. the typical numerical phasing errors over t ... | 2010 | 21231639 |
| do igf-i concentrations better reflect growth hormone (gh) action in children with short stature than the results of gh stimulating tests? evidence from the simultaneous assessment of thyroid function. | 2011 | 21232100 | |
| [the sentinel lymph node mapping in colon cancer]. | malignant tumors of the colon can metastases along the lymphatic system in a sequential way, which means that there will be a first node to be involved and then from this disease will pass to another node and so gradually. the sentinel lymph node is the first lymph node or group of nodes reached by metastasizing cancer cells from a tumor. | 2010 | 21232204 |
| objective evaluation of patients with palmar hyperhidrosis submitted to two levels of sympathectomy: t3 and t4. | this study compares the results obtained of video-assisted sympathectomy performed on two distinct ganglion levels (third vs. fourth thoracic ganglion) in the treatment of palmar hyperhidrosis (ph), through a blind randomized clinical trial. all participants were randomized into two groups of 20 patients (g3 and g4) and underwent the operation, and were followed for 12 months. we used an objective method for measuring sweat, checking the transepidermal water loss (tewl), and evaluated the qualit ... | 2011 | 21233258 |
| age-dependent variation in hormonal concentration and biochemical constituents in blood plasma of indian native fowl. | this experiment was to investigate the age-related changes in hormonal concentration and biochemical constituents of blood plasma in indian native desi fowl. one hundred and sixty two (54 from each breed, i.e., kadaknath (kn), aseel peela (ap), and white leghorn (wlh)) day-old female chicks were randomly divided into nine groups each of 18 chicks (3 groups × 3 replicates). wlh was taken in this study to compare the characteristics of indian native desi fowl. the highest level of estrogen hormone ... | 2010 | 21234314 |
| endorectal ultrasound in rectal carcinoma--do the literature results really correspond to the realities of routine clinical care? | this multicenter, prospective, country-wide quality-assurance study at more than 300 hospitals in germany was designed to characterize and analyze the diagnostic accuracy of rectal endoscopic ultrasound (eus) in the routine clinical staging of rectal carcinoma (depth of tumor infiltration). | 2011 | 21234855 |
| thyroid status of space shuttle crewmembers: effects of iodine removal. | iodine is often used for water purification and has been used throughout the u.s. space program. because of concern about potential effects on crewmembers' thyroid function, in 1997 a system was implemented on board the space shuttles to remove iodine from water before it was consumed. we report here thyroid hormone data from crews flying before and after this system was implemented. | 2011 | 21235106 |
| plasma acetate, gluconate and interleukin-6 profiles during and after cardiopulmonary bypass: a comparison of plasma-lyte 148 with a bicarbonate-balanced solution. | as even small concentrations of acetate in the plasma result in pro-inflammatory and cardiotoxic effects, it has been removed from renal replacement fluids. however, plasma-lyte 148 (plasma-lyte), an electrolyte replacement solution containing acetate plus gluconate is a common circuit prime for cardio-pulmonary bypass (cpb). no published data exist on the peak plasma acetate and gluconate concentrations resulting from the use of plasma-lyte 148 during cpb. | 2011 | 21235742 |
| immediate effects of the audible pop from a thoracic spine thrust manipulation on the autonomic nervous system and pain: a secondary analysis of a randomized clinical trial. | this study investigated the immediate effects of audible joint sounds following a supine t3-t4 spinal thrust manipulation on the autonomic nervous system activity using a fully automated pupillometry system in patients with chronic neck pain. an additional aim was to determine if audible sounds as perceived by the therapist were associated with the reduction of pain following manipulation. | 2011 | 21237406 |
| endonuclease vii is a key component of the mismatch repair mechanism in bacteriophage t4. | in previous papers we described an extra recombination mechanism in t4 phage, which contributed to general recombination only when particular mutations were used as geneticmarkers (high recombination or hr markers), whereas it was practically inactive towards other riib mutations (low recombination or lr markers). this marker-dependent recombination pathway was identified as a repair of mismatches in recombination heteroduplexes. we suggested that the first step in this pathway, recognition and ... | 2011 | 21237725 |
| analysis of preexistent vertebral rotation in the normal infantile, juvenile, and adolescent spine. | vertebral rotation was systematically analyzed in the normal, nonscoliotic thoracic spine of children aged 0 to 16 years. subgroups were created to match the infantile, juvenile, and adolescent age groups according to the criteria of the scoliosis research society. | 2011 | 21240053 |
| comparative analysis of the revised directive 2010/63/eu for the protection of laboratory animals with its predecessor 86/609/eec - a t4 report. | on 8th september 2010 the long process of revising the eu directive for the protection of laboratory animals was concluded. here a comparative evaluation of the new and old directive is provided. while its ultimate goal is to replace the use of animals, the new directive acknowledges that animals, including nonhuman primates, are still needed for scientific purposes today. importantly, animals have an intrinsic value, which must be respected. there are some major advances for animal welfare, man ... | 2010 | 21240470 |
| is neoadjuvant chemotherapy prior to radio-chemotherapy beneficial in t4 anal carcinoma? | this study retrospectively describes the outcome of a series of 38 patients (pts) with t4 anal carcinoma exclusively treated by radio and chemotherapy. | 2011 | 21240983 |
| induction chemotherapy for advanced squamous cell carcinoma of the paranasal sinuses. | to review the oncologic outcomes in patients with advanced (stage iii-iv) squamous cell carcinoma of the paranasal sinuses treated with induction chemotherapy prior to definitive local therapy. | 2011 | 21242552 |
| metabolic disorders prevalence in sudden deafness. | the aim of the present study was to establish the frequency of metabolic disorders among patients with sudden deafness and to compare this frequency with data from population surveys. | 2010 | 21243289 |
| t2-t4 sympathectomy versus t3-t4 sympathicotomy for palmar and axillary hyperhidrosis. | to evaluate and compare the immediate and long-term outcomes of videothoracoscopic t2-t4 sympathectomy and t3-t4 sympathicotomy for the treatment of palmar and axillary hyperhidrosis. | 2011 | 21243401 |
| the prevalence of vertebral fractures and health-related quality of life in postmenopausal women. | vertebral fractures are the hallmark of osteoporosis, responsible for increased back pain, impairment of mobility and functional limitations. these factors have an impact on patients' health-related quality of life (qol). the aim of this study was to evaluate the prevalence of vertebral fractures in moroccan postmenopausal women and to assess their qol, using an arabic validated version of qualeffo. the study recruited 347 postmenopausal women in obvious good health. we excluded women who had us ... | 2011 | 21243498 |
| relevance of autoimmune thyroiditis in children and adolescents with vitiligo. | vitiligo is the most common pigmentation-related disorder worldwide. an autoimmune etiology is widely considered, and genetic factors may play an important role in its pathogenesis. the purpose of this study was to assess the incidence of thyroid dysfunctions and autoimmune thyroiditis in children with vitiligo and to identify related factors. | 2011 | 21244381 |
| foxp3 and survival in urinary bladder cancer. | objective: • to investigate the possible impact of foxp3 expression in t-cells, as well as in tumour cells, on long-term survival in patients with urinary bladder cancer (ubc) invading muscle. patients and methods: • in a retrospective study, tumour specimens from 37 patients cystectomized for t1-t4 ubc during 1999-2002 at the karolinska university hospital were examined by immunohistochemistry for tumour expression and/or infiltration of immune cells expressing foxp3 as well as cd3. • the resul ... | 2011 | 21244603 |
| bosentan treatment for raynauds phenomenon and skin fibrosis in patients with systemic sclerosis and pulmonary arterial hypertension: an open-label, observational, retrospective study. | raynaud?s phenomenon (rp) and cutaneous fibrosis are the distinctive manifestations of scleroderma, in which endothelin-1 plays a fundamental pathogenetic role. bosentan, an endothelin-1 receptor antagonist used for the treatment of pulmonary arterial hypertension, retards the beginning of new sclerodermic digital ulcers (du). this open-label, observational, retrospective study verified the effect of bosentan on rp and skin fibrosis in sclerodermic outpatients affected by pulmonary arterial hype ... | 2010 | 21244767 |
| [surgical treatment of lung cancer by video-assisted thoracoscopic surgery.] | background: to investigate the role of curative and palliative surgical treatment of lung cancer with video-assisted thoracoscopic surgery (vats). methods: forty-three patients with lung cancer were prescribed operations with vats, which included 5 cases of stage ia, 14 cases of ib, 1 case of iia, 4 cases of iib, 7 cases of iiia, 6 cases of t4-iiib and 6 cases of iv. the 7 patients of stage iiia were previously staged as n0 before operation, but reevaluated as n2-iiia after operation. there were ... | 2004 | 21244798 |
| [thoracic spine pseudarthrosis treated by transpleural corporectomy and bone morphogenic protein]. | traumatic thoracic spine instability is a rare but difficult-to-treat entity, particularly above t5 where pedicle screwing is widely regarded as an unsatisfactory option and anterior surgery is considered difficult because of the anatomic relationship with the shoulder and large vessels. | 2011 | 21247607 |
| hypothyroxinemia and pregnancy. | to evaluate the peer-reviewed literature on iodine deficiency and hypothyroxinemia in pregnancy. | 2011 | 21247845 |
| a brief review of voice restoration following total laryngectomy. | despite advances in conservative laryngeal surgery and radiotherapy, total laryngectomy still remains the procedure of choice for advanced-stage (uicc t3 and t4) laryngeal carcinoma, around the world. the functional rehabilitation of the laryngectomized patients has been a concern of head and neck surgeons and speech therapists. significant developments in speech rehabilitation over the past three decades have led to substantial improvements in the quality of life of these patients. the tracheoe ... | 2011 | 21248437 |
| bioenergetic impact of tissue-specific regulation of iodothyronine deiodinases during nutritional imbalance. | the regulation of energy homeostasis by thyroid hormones is unquestionable, and iodothyronine deiodinases are enzymes involved in the metabolic activation or inactivation of these hormones at the cellular level. t3 is produced through the outer ring deiodination of the prohormone t4, which is catalyzed by types 1 and 2 iodothyronine deiodinases, d1 and d2. conversely, type 3 iodothyronine deiodinase (d3) catalyzes the inner ring deiodination, leading to the inactivation of t4 into reverse triiod ... | 2011 | 21249435 |
| advances in patient safety: new directions and alternative approaches (vol. 3: performance and tools) | objective: maintenance of competence in orotracheal intubation skills is challenging for non-anesthesiologists who do not practice intubation routinely. we hypothesized that discipline, recent training, and experience would affect immediate skill improvement during refresher training. methods: experienced pediatric providers refreshed intubation skills in six simulated infant trauma scenarios with cervical spine protection. time (t) to successful intubation (in seconds) was used to calculate ref ... | 2008 | 21249918 |
| clinical methods: the history, physical, and laboratory examinations | thyroid function tests are designed to distinguish hyperthyroidism and hypothyroidism from the euthyroid state. to accomplish this task, direct measurements of the serum concentration of the two thyroid hormones—triiodothyronine (t3) and tetraiodothyronine (t4)—more commonly known as thyroxine, are extensively employed. the t3 resin uptake (t3ru) is used as an indirect measure of serum thyroid hormone binding capacity, and the free t4 index (ft4i), derived from the t4 and t3ru, corrects estimate ... | 1990 | 21250093 |
| the effects of creep and recovery on the in vitro biomechanical characteristics of human multi-level thoracolumbar spinal segments. | several physiological and pathological conditions in daily life cause sustained static bending or torsion loads on the spine resulting in creep of spinal segments. the objective of this study was to determine the effects of creep and recovery on the range of motion, neutral zone, and neutral zone stiffness of thoracolumbar multi-level spinal segments in flexion, extension, lateral bending and axial rotation. | 2011 | 21251737 |
| lithium in drinking water and thyroid function. | background: high concentrations of lithium in drinking water were previously discovered in the argentinean andes mountains. lithium is used worldwide for treatment of bipolar disorder and treatment-resistant depression. one known side effect is altered thyroid function.objectives: we assessed associations between exposure to lithium from drinking water and other environmental sources and thyroid function.methods: women (n = 202) were recruited in four andean villages in northern argentina. lithi ... | 2011 | 21252007 |
| is a right pedicle screw always away from the aorta in scoliosis? | : study design: retrospective analysisobjective: we evaluated the aorta safety in placement of a right pedicle screw in scoliotic patients.summary of background data: past reports emphasized the aorta risk in placing pedicle screws on the concave left side in right thoracic scoliosis. however, risk on the right side has drawn limited interest.methods: thirty-four scoliotic patients with an average age of 18.0 years were evaluated. the cobb angle averaged 59.0°±14.0°. from computed tomographic da ... | 2011 | 21252823 |
| bones and crohn's: no benefit of adding sodium fluoride or ibandronate to calcium and vitamin d. | to compare the effect of calcium and cholecalciferol alone and along with additional sodium fluoride or ibandronate on bone mineral density (bmd) and fractures in patients with crohn's disease (cd). | 2011 | 21253392 |
| commentary on 't4 colorectal cancer: is laparoscopic resection contraindicated?' by bretagnol et al. | 2011 | 21255218 | |
| redox-responsive zinc finger fidelity switch in homing endonuclease and intron promiscuity in oxidative stress. | it is well understood how mobile introns home to allelic sites, but how they are stimulated to transpose to ectopic locations on an evolutionary timescale is unclear. here we show that a group i intron can move to degenerate sites under oxidizing conditions. the phage t4 td intron endonuclease, i-tevi, is responsible for this infidelity. we demonstrate that i-tevi, which promotes mobility and is subject to autorepression and translational control, is also regulated posttranslationally by a redox ... | 2011 | 21256016 |
| aortic endostent followed by extended pneumonectomy for t4 lung cancer. | pulmonary and aortic en bloc resection may be performed with cardiopulmonary bypass support, but is associated with high surgical morbidity and mortality. a 59-year-old man with left lower lobe cancer invading the aorta was considered to be unsuitable for such an extended operation because of previous myocardial infarction, coronary bypass grafts, and subsequent multiple coronary artery stenting. pneumonectomy with en bloc resection of aortic adventitia and media was accomplished after thoracic ... | 2011 | 21256322 |
| comparison of progressive cephalometric changes and postsurgical stability of skeletal class iii correction with and without presurgical orthodontic treatment. | this study compares 1) progressive dental and skeletal changes, 2) postsurgical stability, and 3) treatment efficacy of patients with skeletal class iii correction with and without presurgical orthodontic treatment. | 2011 | 21256648 |
| duplication of calsequestrin genes in teleosts: molecular characterization in the senegalese sole (solea senegalensis). | calsequestrin is a moderate-affinity, high-capacity ca(2+) binding protein in the sarcoplasmic reticulum of skeletal and cardiac muscle that seems to act as an intralumenal ca(2+) buffer. two different isoforms have been described in mammals, the skeletal and cardiac isoforms, encoded by casq1 and casq2 genes, respectively. in this study, we present molecular phylogenetic evidence of a gene duplication event of both calsequestrin genes in teleosts, referred to as casq1a/casq1b and casq2a/casq2b. ... | 2011 | 21256971 |
| mutational analysis of residues in the helical region of the class iia bacteriocin pediocin pa-1. | a 15-mer fragment that is derived from the helical region in the c-terminal half of pediocin pa-1 inhibited the activity of pediocin pa-1. of 13 other pediocin-like (hybrid) bacteriocins, only the hybrid bacteriocin sak/ped was markedly inhibited by the 15-mer fragment. sak/ped was the only one of these bacteriocins that had a sequence (in the c-terminal helix-containing half) identical to that of the 15-mer fragment, indicating that the fragment inhibits pediocin-like bacteriocins in a sequence ... | 2011 | 21257813 |
| a research framework for reducing preventable patient harm. | programs to reduce central line-associated bloodstream infections (clabsis) have improved the safety of hospitalized patients. efforts are underway to disseminate these successes broadly to reduce other types of hospital-acquired infectious and noninfectious preventable harms. unfortunately, the ability to broadly measure and prevent other types of preventable harms, especially infectious harms, needs enhancement. moreover, an overarching research framework for creating and integrating evidence ... | 2011 | 21258104 |
| hedgehog-mediated regulation of thyroid hormone action through iodothyronine deiodinases. | introduction: the three iodothyronine deiodinases catalyze the metabolic pathway that removes one iodine residue from the t4 molecule, thus producing either the active t3 or the inactive metabolite rt3. hence, deiodination is a potent mechanism by which to modulate thyroid hormone (th) action at cellular level, thereby allowing cells to customize their own t3 availability, both spatially and temporally, irrespective of th serum concentrations. sonic hedgehog (hh) regulates patterning and growth ... | 2011 | 21261564 |
| decreasing enterobacter sakazakii (cronobacter spp.) food contamination level with bacteriophages: prospects and problems. | enterobacter sakazakii (cronobacter spp.) is an opportunistic pathogen, which can cause rare, but life-threatening infections in neonates and infants through feeding of a contaminated milk formula. we isolated 67 phages from environmental samples and tested their lytic host range on a representative collection of 40 e. sakazakii strains. a cocktail of five phages prevented the outgrowth of 35 out of 40 test strains in artificially contaminated infant formula. two e. sakazakii phages represented ... | 2008 | 21261874 |
| metformin decreases thyrotropin in overweight women with polycystic ovarian syndrome and hypothyroidism. | to assess the effect of metformin administration on thyroid function in overweight women with polycystic ovarian syndrome (pcos). | 2011 | 21262871 |
| thyroid hormone therapy modulates hypothalamo-pituitary-adrenal axis. | to observe the influence of thyroid hormone therapy on hypothalamo-pituitary-adrenal (hpa) axis, a group of 14 athyreotic women due to thyroid cancer treatment were studied before and after thyroid suppression therapy with thyroxine (t4). changes in plasma adrenocorticotropin (acth) and cortisol levels in response to human corticotropin-releasing hormone (hcrh; 100µg, i.v.) were estimated under hypothyroid conditions and after t4 suppression therapy with 2.5µg/kg/day for two months (n=14). a gro ... | 2011 | 21263198 |
| quantitative analysis of promoter methylation of the ednrb gene in gastric cancer. | hypermethylation has been shown in the promoter region of the endothelin receptor b (ednrb) gene in several human tumors. however, its role in gastric cancer formation is still unclear. in this study, the methylation status of the ednrb gene in paired gastric cancer tissues and adjacent normal tissues from 96 patients was detected quantitatively using pyrosequencing. the results showed the methylation of promoter of ednrb gene in gastric cancer (50.42 ± 9.03%) was significantly higher than in ad ... | 2011 | 21264540 |
| [clinical application of "funnel technique" in planting thoracic pedicle screws]. | to evaluate the safety and accuracy of "funnel technique" in planting thoracic pedicle screws. | 2010 | 21265197 |
| sensitivity to low-dose/low-let ionizing radiation in mammalian cells harboring mutations in succinate dehydrogenase subunit c is governed by mitochondria-derived reactive oxygen species. | it has been hypothesized that ionizing radiation-induced disruptions in mitochondrial o₂ metabolism lead to persistent heritable increases in steady-state levels of intracellular superoxide (o₂(•u+2212)) and hydrogen peroxide (h₂o₂) that contribute to the biological effects of radiation. hamster fibroblasts (b9 cells) expressing a mutation in the gene coding for the mitochondrial electron transport chain protein succinate dehydrogenase subunit c (sdhc) demonstrate increases in steady-state level ... | 2010 | 21268708 |
| laryngeal carcinoma metastasis to the orbit: case report. | we present the first report in the all english literature of a case of laryngeal squamous cell carcinoma metastasis to the orbit. | 2011 | 21269558 |
| targeted thyroid testing in acute illness - achieving success through audit. | thyroid tests are done in acutely ill patients who often have confusing transient thyroid abnormalities, despite a lack of clarity about intervention and cost benefit. a retrospective analysis of patients admitted to the medical assessment unit [mau] was undertaken in 2004 to assess the frequency and utility, pattern of abnormalities and cost of thyroid testing. guidelines were issued and the audit was repeated in 2008. 53.8% of 1593 were offered thyroid tests in 2004 with a significant reductio ... | 2011 | 21270508 |
| thoracic pedicle morphometry in different body-height population: a three dimensional study using reformatted computed tomography. | study design. a three-dimensional study of the thoracic pedicle (t1-t12) morphometry in chinese patients, with different body-height, using reformatted computed tomography.objective. to quantify the dimensions of the thoracic pedicles and to analyze the relationship between body-height and thoracic pedicle parameters.summary of background data. the thoracic pedicle morphometry has been studied extensively in different populations using various techniques. previous studies have shown a significan ... | 2011 | 21270680 |
| integrated analysis of the conformation of a protein-linked spin label by crystallography, epr and nmr spectroscopy. | long-range structural information derived from paramagnetic relaxation enhancement observed in the presence of a paramagnetic nitroxide radical is highly useful for structural characterization of globular, modular and intrinsically disordered proteins, as well as protein-protein and protein-dna complexes. here we characterized the conformation of a spin-label attached to the homodimeric protein cylr2 using a combination of x-ray crystallography, electron paramagnetic resonance (epr) and nmr spec ... | 2011 | 21271275 |
| thyroid hormones (t3 and t4): dual effect on human cancer cell proliferation. | several findings suggest that the patient's hormonal context plays a crucial role in determining cancer outcome. the exact nature of thyroid hormone action on tumour growth has not been established yet, in fact contrasting data show thyroid hormones have a promotory or an inhibitory action on cancer cell proliferation depending on the case. we hypothesized that not only tissue specificity, but also specific mutations occurring during tumoral development in different thyroid hormone cellular targ ... | 2011 | 21273585 |
| effect of hypo-and euthyroid status on serum cystatin c levels. | objective: the aim of this study was to investigate the effect of hypo- and euthyroid status on serum cystatin c (cysc) levels in children and to explore whether cysc can be used as a marker of the thyroid status.methods: twenty five patients with hypothyroidism (10m, 15f; mean age:8.7±4.9 years) and 21 healhty age-matched controls (9m, 12f; mean age: 9.7±5.0 years) were included in this study. serum thyrotropin (tsh), free thyroxine (ft4), serum cysc and creatinine levels were studied in patien ... | 2010 | 21274315 |
| hypothyroidism due to hepatic hemangioendothelioma: a case report. | although hemangioendothelioma (hhe) is a commonly encountered hepatic tumor during infancy, hhe-related hypothyroidism is rare. we present a patient who developed hhe-related hypothyroidism during the neonatal period and showed marked improvement in hypothyroidism by regression of hhe. a 28-day-old boy with tsh level of 77 miu/ml on neonatal screening and diagnosed as congenital hypothyroidism was started on l-thyroxine (l-t4) (11 μg/kg/day) therapy on the 21(th) day of life. on physical examina ... | 2010 | 21274327 |
| coagulation disorders in patients with locally advanced head and neck cancer - should they really be disregarded? | the aim of the study was to analyse coagulation disorders in patients with locally advanced cancer of the head and neck (chn)and with no other clinical cause for coagulation disorders treated with radiation therapy alone or concurrent chemoradiotherapy. we also assessed the duration of disorders in the course of therapy. the analysed group consisted of 33 patients with locally advanced chn documented as stage t3 or t4 acc. to the tnm classification. coagulology tests (activated partial thrombopl ... | 2011 | 21275462 |
| long-term stability after multilevel cervical laminectomy for spinal cord tumor resection in von hippel-lindau disease. | despite the frequent multiplicity and development of new spinal cord hemangioblastomas that require multiple resections in patients with von hippel-lindau (vhl) disease, the long-term effects of spinal surgery on spinal column stability in this neoplasia disorder are not known. to determine the effect of multilevel cervical laminectomy for spinal cord tumor resection in vhl, the authors analyzed long-term clinical and radiographic outcomes. | 2011 | 21275550 |
| cervical lymph node metastases in squamous cell carcinoma of tongue and floor of mouth. | oral squamous cell carcinoma has high chances of cervical lymph node metastasis. this case series describes the distribution of cervical lymph nodes in 50 cases of squamous cell carcinoma of tongue and floor of mouth. the mean age was 47.28±10.5 years. thirty positive metastatic lymph nodes were found; 90% occurring at level i-ii mostly in t4 size but also in t1 and t2 cases. the distribution of involved lymph nodes in oral cancer affects the neck dissection extent and is, therefore, an importan ... | 2011 | 21276390 |
| effect of whole pelvic radiotherapy for patients with locally advanced prostate cancer treated with radiotherapy and long-term androgen deprivation therapy. | purpose: to evaluate the effect of whole pelvic radiotherapy (wprt) in prostate cancer patients treated with rt and long-term (>1 year) androgen deprivation therapy (adt). methods and materials: prostate cancer patients with high-risk features (stage t3-t4 and/or gleason score =7 and/or prostate-specific antigen level =20 ng/ml) who had undergone rt and long-term adt were included in the present analysis. patients with bowel inflammatory disease, colon diverticula, and colon diverticulitis were ... | 2011 | 21277100 |
| [pleural metastases from bronchial carcinoma: is a cure possible?]. | the 2009 tnm classification of lung cancer reclassified patients with pleural invasion from stage iiib (t4) to stage iv (m+). however, the 2009 tnm separates patients with pleural metastases (m1a) from patients with others visceral metastases (m1b), the patients with stage m1a having the better prognosis. | 2010 | 21277479 |
| impact of neoadjuvant chemoradiotherapy followed by surgical resection on node-negative t3 and t4 non-small cell lung cancer. | this study examined the impact of neoadjuvant chemotherapy and concurrent high-dose radiation therapy on survival in patients with node-negative t3 and t4 non-small cell lung cancer. | 2011 | 21281948 |
| [knot in a thoracic epidural catheter]. | we report a case of impossible injection into a thoracic epidural catheter associated with a difficult withdrawal of this catheter after its introduction on the t3-t4 level. thanks to a gentle and continuous traction, the catheter was finally successfully removed without being broken, but presented a simple knot at 13mm from its end. no neurological complication was observed later on. this complication happened during the introduction of the catheter at the thoracic level where anatomic conditio ... | 2011 | 21282033 |
| tumor site and perigastric nodal status are the most important predictors of para-aortic nodal involvement in advanced gastric cancer. | this study was designed to identify pathological predictors of para-aortic nodal invasion in advanced gastric cancer. | 2011 | 21286941 |
| intensity-modulated radiation therapy versus conventional radiation therapy for squamous cell carcinoma of the anal canal. | the purpose of this study was to compare outcomes in patients with anal canal squamous cell carcinoma (scca) who were treated with definitive chemoradiotherapy by either intensity-modulated radiation therapy (imrt) or conventional radiotherapy (crt). | 2011 | 21287530 |
| the terminal region of the e. coli chromosome localises at the periphery of the nucleoid. | bacterial chromosomes are organised into a compact and dynamic structures termed nucleoids. cytological studies in model rod-shaped bacteria show that the different regions of the chromosome display distinct and specific sub-cellular positioning and choreographies during the course of the cell cycle. the localisation of chromosome loci along the length of the cell has been described. however, positioning of loci across the width of the cell has not been determined. | 2011 | 21288323 |
| a novel method for testing the veridicality of dental colour assessments. | the commission internationale de l'eclairage (cie) l*a*b* three-dimensional coordinates suggest strong correlations between the data of a* (red-green axis) and b* (blue-yellow axis), as both are located on the same plane in the model and should therefore show a strong dependency. in order to assess the veridicality of colour determinations, the null hypothesis of no significant changes in cie-a*/b* coherences of dental colours following a colour or lightness change induced by external dental ble ... | 2011 | 21289016 |
| loss of asparagine-linked glycosylation sites in variable region 5 of human immunodeficiency virus type 1 envelope is associated with resistance to cd4 antibody ibalizumab. | ibalizumab (formerly tnx-355) is a first-in-class, monoclonal antibody inhibitor of cd4-mediated human immunodeficiency type 1 (hiv-1) entry. multiple clinical trials with hiv-infected patients have demonstrated the antiviral activity, safety, and tolerability of ibalizumab treatment. a 9-week phase ib study adding ibalizumab monotherapy to failing drug regimens led to transient reductions in hiv viral loads and the evolution of hiv-1 variants with reduced susceptibility to ibalizumab. this repo ... | 2011 | 21289125 |
| the volumetric analysis of cement in vertebroplasty: relationship with clinical outcome and complications. | prospective study. | 2011 | 21289575 |
| bilateral pars fractures complicating long fusion to l5 in a patient with rheumatoid arthritis. | case report. | 2011 | 21289579 |
| surgical resection and survival of patients with unsuspected single node positive lung cancer (nsclc) invading the descending aorta. | background: surgical treatment of non-small cell lung cancer (nsclc) with aortic invasion is still debated.methods: thirteen patients with locally advanced (t4) nsclc and invasion of the descending aorta underwent pneumonectomy (n=9) or lobectomy (n=4) together with aorta en bloc resection and reconstruction (n=8) or subadventitial dissection (n=5), complete lymph node dissection, and had microscopic unsuspected node metastasis at n1 (n=5) and n2/3 (n=8) levels of whom 12 received radiation ther ... | 2009 | 21289904 |
| concurrent cisplatin, continuous infusion fluorouracil and radiotherapy followed by tailored consolidation treatment in non metastatic anal squamous cell carcinoma. | to evaluate efficacy and feasibility of chemo-radiotherapy in patients with non-metastatic anal squamous-cell-cancer. | 2011 | 21291546 |
| cdna library generation from ribonucleoprotein particles. | most, if not all, known noncoding rnas (ncrnas) are associated with rna binding proteins, thus forming ribonucleoprotein particles or rnps. here we describe a protocol for the generation of a specialized cdna library from rnps, thereby increasing the proportion of functional ncrna species in the library. to that end, cellular extracts are fractionated on 10-30% glycerol gradients. subsequently, rnp-derived ncrnas are isolated and 3'-tailed by cytidine triphosphate and poly(a) polymerase; this is ... | 2011 | 21293458 |
| general anesthesia with thoracic paravertebral block for modified radical mastectomy. | to evaluate the effect of single-injection paravertebral block (pvb) combined with general anesthesia on 24-hour postoperative morphine requirement in patients undergoing modified radical mastectomy (mrm). | 2010 | 21294410 |
| effects of methylphenidate on performance of a practical pistol shooting task: a quantitative electroencephalography (qeeg) study. | 2011 | 21294887 | |
| two-year results from a swedish study on conventional versus accelerated radiotherapy in head and neck squamous cell carcinoma - the artscan study. | studies on accelerated fractionation (af) in head and neck cancer have shown increased local control and survival compared with conventional fractionation (cf), while others have been non-conclusive. in 1998 a national swedish group decided to perform a randomised controlled clinical study of af. | 2011 | 21295880 |
| a rare case of anterior thoracic myelomeningocele with scoliosis--case report and review of the literature. | spinal deformities associated with spinal dysraphism are a challenging problem. myelomeningocele has been reported in the lumbar spine. however, it is rare in the thoracic spine. | 2011 | 21296287 |
| recombinant human thyroid stimulating hormone in thyroid remnant ablation with 1.1 gbq 131iodine in low-risk patients. | objective: to evaluate the efficacy of recombinant human thyroid stimulating hormone [rhtsh (versus hypothyroidism)] in thyroid ablation with an activity of 1.1 gbq (30 mci) i. methods: a total of 102 patients with thyroid cancer who fulfilled the following criteria were studied: submitted to total thyroidectomy with complete tumor resection; tumor =4 cm without extrathyroid invasion or lymph node metastases; negative anti-thyroglobulin (anti-tg) antibodies. thirty-two patients (group a) receive ... | 2011 | 21297429 |
| discovering conformational sub-states relevant to protein function. | internal motions enable proteins to explore a range of conformations, even in the vicinity of native state. the role of conformational fluctuations in the designated function of a protein is widely debated. emerging evidence suggests that sub-groups within the range of conformations (or sub-states) contain properties that may be functionally relevant. however, low populations in these sub-states and the transient nature of conformational transitions between these sub-states present significant c ... | 2011 | 21297978 |
| clinicopathologic features and prognosis analysis of mucinous gastric carcinoma. | mucious gastric carcinoma (mgc) is a subtype of gastric carcinoma and its clinicopathologic features and prognosis still remain unclear. to investigate the clinical significance and surgical outcomes of mucinous gastric carcinoma, 2,769 patients with gastric carcinoma were analyzed in a case control study. we reviewed the records of 196 patients with mucinous gastric carcinoma and 2,573 with nonmucinous gastric carcinoma (ngc). clinicopathologic features and survival rate of patients were analyz ... | 2011 | 21298368 |