Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| novel mutations of ext1 and ext2 genes among families and sporadic cases with multiple exostoses. | hereditary multiple exostoses (hme) is an autosomal dominantly inherited disorder characterized by multiple benign cartilage-capped exostoses. clinical manifestation of the disease is heterogenous. overriding toes, scoliosis, spinal cord compression, and brachydactyly caused by shortening of metatarsals are rare findings. ext1 and ext2 are the genes responsible in most hme patients. we have characterized 11 hme families and 6 sporadic cases involving a total of 37 patients and performed mutation ... | 2010 | 21039224 |
| volume gain and stability of peri-implant tissue following bone and soft tissue augmentation: 1-year results from a prospective cohort study. | the aim of the present study was to evaluate the dimensional changes of peri-implant tissues obtained by implant placement, bone and soft tissue augmentation, prosthetic reconstruction and 1 year of function using a new, non-invasive method for volumetric measurements. | 2010 | 21039891 |
| evaluation of butorphanol, medetomidine and midazolam as a reversible narcotic combination in free-ranging african lions (panthera leo). | to evaluate the effects of the combination butorphanol, medetomidine and midazolam (bmm) and its reversibility in lions. | 2010 | 21040373 |
| comparison of analgesia provided by lidocaine, lidocaine-morphine or lidocaine-tramadol delivered epidurally in dogs following orchiectomy. | to evaluate and compare the postoperative analgesia provided by epidural lidocaine, lidocaine/morphine or lidocaine/tramadol in dogs following elective orchiectomy. | 2010 | 21040378 |
| patient reported outcomes in head and neck cancer: selecting instruments for quality of life integration in clinical protocols. | health related quality of life has been used in medical research for more than twenty years, being progressively accepted during the last decade as an important patient reported outcome. considering the multidimensional approach involved in health related quality of life assessment, instrument applicability and cultural adaptation must be tested for each population. in order to select the most appropriate instrument for head and neck cancer patients, two major health related quality of life spec ... | 2010 | 21040524 |
| two-stage, self-cycling process for the production of bacteriophages. | a two-stage, self-cycling process for the production of bacteriophages was developed. the first stage, containing only the uninfected host bacterium, was operated under self-cycling fermentation (scf) conditions. this automated method, using the derivative of the carbon dioxide evolution rate (cer) as the control parameter, led to the synchronization of the host bacterium. the second stage, containing both the host and the phage, was operated using self-cycling infection (sci) with cer and cer-d ... | 2010 | 21040541 |
| [a method for individualising the risk of a negative lymph node classification error in cancer of the colon]. | in cancer of the colon, the number of lymph nodes that should be analysed before a patient is classified as free of lymph node involvement has been widely discussed. a mathematical model is proposed which is based on the bayes theorem for calculating the probability of error (pe) similar to that normally used to evaluate a diagnostic test, but adapted to a quantitative variable, the lymph node count. | 2010 | 21040908 |
| minimally invasive endoscopic resection of sinonasal undifferentiated carcinoma. | purpose: the purpose of the study was to review a single-institution experience with endoscopic resection of sinonasal undifferentiated carcinoma (snuc). materials and methods: thirteen patients underwent treatment of snuc between january 2002 and july 2009. retrospective data were collected including demographics, tumor characteristics, surgical strategy, adjuvant therapies, local and regional recurrence, distant metastasis, overall survival, and disease-free survival. results: the mean age was ... | 2010 | 21041001 |
| structure of the bacteriophage t4 long tail fiber receptor-binding tip. | bacteriophages are the most numerous organisms in the biosphere. in spite of their biological significance and the spectrum of potential applications, little high-resolution structural detail is available on their receptor-binding fibers. here we present the crystal structure of the receptor-binding tip of the bacteriophage t4 long tail fiber, which is highly homologous to the tip of the bacteriophage lambda side tail fibers. this structure reveals an unusual elongated six-stranded antiparallel ... | 2010 | 21041684 |
| oral sodium bicarbonate improves thyroid function in predialysis chronic kidney disease. | metabolic acidosis (ma) in chronic kidney disease (ckd) associates with protein energy malnutrition, osteoporosis, abnormal endocrine function and increased mortality. oral sodium bicarbonate has been shown to improve nutritional status and preserve renal function in ckd. depressed thyroid function has been described in ckd and was believed to be related to ma. this is a prospective randomized study that examined the effect of oral sodium bicarbonate on thyroid function in predialysis ckd with m ... | 2010 | 21042013 |
| learn 2 move 7-12 years: a randomized controlled trial on the effects of a physical activity stimulation program in children with cerebral palsy. | regular participation in physical activities is important for all children to stay fit and healthy. children with cerebral palsy have reduced levels of physical activity, compared to typically developing children. the aim of the learn 2 move 7-12 study is to improve physical activity by means of a physical activity stimulation program, consisting of a lifestyle intervention and a fitness training program. | 2010 | 21044314 |
| what is the best way to diagnose and stage malignant pleural mesothelioma? | a best evidence topic in thoracic surgery was written according to a structured protocol. the question addressed was which diagnostic modality [computed tomography (ct), positron emission tomography (pet), combination pet/ct and magnetic resonance imaging (mri)] provides the best diagnostic and staging information in patients with malignant pleural mesothelioma (mpm). overall, 61 papers were found using the reported search, of which 14 represented the best evidence to answer the clinical questio ... | 2010 | 21044972 |
| perfluorooctane sulfonate increased hepatic expression of oapt2 and mrp2 in rats. | the toxicity of perfluorooctane sulfonate (pfos), a persistent organic compound, is of great concern. several studies have reported that pfos decreases circulating thyroid hormone (th) concentrations. however, the mechanisms involved remain to be determined. female rats were exposed to (1) vehicle; (2) pfos (0.2, 1.0, and 3.0 mg/kg); (3) propylthiouracil (ptu, 10 mg/kg); or (4) ptu (10 mg/kg) + pfos (3.0 mg/kg) by gavage once a day for 5 consecutive days. parameters including contents of total t ... | 2010 | 21046362 |
| anti-saccaromyces cerevisiae antibodies (asca) are elevated in autoimmune thyroid disease asca in autoimmune thyroid disease. | environmental factors have been implicated in the development of autoimmune thyroid disease (aitd). anti-saccaromyces cerevisiae antibodies (asca) were shown to be elevated in several autoimmune diseases. the aim of the study was to determine asca levels and their relationship with thyroid autoantibodies in patients with aitd. one-hundred and twelve patients with aitd (age 41.1±12.8 years; f/m:96/16) and 103 healthy controls (38.5±10.3 years; f/m:82/21) were included. twenty-four patients had gr ... | 2010 | 21046480 |
| efficacy and tolerability of topical 0.05% flunarizine in patients with open-angle glaucoma or ocular hypertension-a pilot study. | aim: to evaluate the efficacy and tolerability of flunarizine, a nonselective calcium channel blocker, on intraocular pressure (iop) in patients with open-angle glaucoma (oag) or ocular hypertension (oh). design: randomized, placebo-controlled, double blind, cross-over phase ii trial. methods: ten patients diagnosed with bilateral oag or oh were included. each patient served as his own control. on the first study visit, 1 drop of either 0.05% flunarizine or placebo was applied in the study eye. ... | 2010 | 21048514 |
| the course of anxiety and depression in patients with breast cancer and gynaecological cancer. | background/aims: the aim of this study was to assess the course of anxiety and depression in cancer patients over time and to detect determinants of the changes in the scores. patients and method: women with breast cancer and gynaecological cancer (n = 367) were tested at the beginning (t1) and at the end (t2) of treatment in the hospital, 6 months later (t3), and 12 months later (t4), using the hospital anxiety and depression scale (hads). results: anxiety and depression were highest at the sta ... | 2008 | 21048913 |
| risk factors associated with the severity of thyroid-associated orbitopathy in korean patients. | the purpose of this study is to identify risk factors for severe thyroid-associated orbitopathy (tao) and compressive optic neuropathy in korean patients. | 2010 | 21052505 |
| the thr92ala 5' type 2 deiodinase gene polymorphism is associated with a delayed triiodothyronine secretion in response to the thyrotropin-releasing hormone-stimulation test: a pharmacogenomic study. | the common thr92ala d2 polymorphism has been associated with changes in pituitary-thyroid axis homeostasis, but published results are conflicting. to investigate the effects of the thr92ala polymorphism on intrathyroidal thyroxine (t4) to triiodothyronine (t3) conversion, we designed prospective pharmacogenomic intervention aimed to detect differences in t3 levels after thyrotropin (tsh)-releasing hormone (trh)-mediated tsh stimulation of the thyroid gland. | 2010 | 21054208 |
| development of a clinical prediction rule for identifying women with tension-type headache who are likely to achieve short-term success with joint mobilization and muscle trigger point therapy. | to identify prognostic factors from the history and physical examination in women with tension-type headache (tth) who are likely to experience self-perceived clinical improvement following a multimodal physical therapy session including joint mobilization and muscle trigger point (trp) therapies. | 2010 | 21054361 |
| thyroxine for transient hypothyroxinemia and cerebral palsy in extremely preterm infants. | background: the relationship of thyroxine supplementation for transient hypothyroxinemia of prematurity to the incidence of cerebral palsy (cp) in infants less than 28 weeks of gestation is unclear. methods: incidence of cp at a corrected age of 18 months was compared between infants born in a 3-year period in which routine measurement of blood free t4 (ft4) was not performed (first period, n = 54), and those born in a later 3-year period in which ft4 was measured (second period, n = 60; mainly ... | 2010 | 21054676 |
| extended staging of oesophageal cancer using fdg-pet - a critical appraisal. | background and aim: oesophageal cancer (oc) is a highly aggressive tumour with unfavorable prognosis due to early stages metastases. treatment and survival rates are highly correlated with tumour wall invasion, lymphatic involvement and metastatic spread. thus, an accurate staging at initial diagnosis is fundamental for optimal management. in the present review article the potential role of the fdg-pet in the staging of oc is discussed. methods: a systematic review of all papers published in pub ... | 2010 | 21055894 |
| correlation of high 18f-fdg uptake to clinical, pathological and biological prognostic factors in breast cancer. | the aim of this study was to determine the impact of the main clinicopathological and biological prognostic factors of breast cancer on (18)f-fluorodeoxyglucose (fdg) uptake. only women with tumours larger than 20 mm (t2-t4) were included in order to minimize bias of partial volume effect. | 2010 | 21057787 |
| [effects of electroacupuncture anesthesia of different frequencies on stress reaction in thyroid surgery]. | to probe into the optimal frequency of electroacupuncture for the access to the best anesthesia. | 2010 | 21058485 |
| anoxybacillus mongoliensis sp. nov., a novel thermophilic proteinase producing bacterium isolated from alkaline hot spring, central mongolia. | a gram reaction positive, spore-forming, facultative anaerobic bacterium belonging to the phylum firmicutes, was isolated from alkaline hot (80 degrees c, ph 9.8 spring tsenher, central mongolia. the cells were rod shaped, feebly motile, peritrichously flagellated. strain t4 was moderately thermophilic with optimum growth at 60 degrees c. maximum temperature for growth was between 70 and 75 degrees c; minimum temperature for growth was between 35 and 30 degrees c. alkalitolerant, optimum ph for ... | 2010 | 21058505 |
| myxedema coma in a patient with subclinical hypothyroidism. | myxedema coma is the extreme manifestation of hypothyroidism, typically seen in patients with severe biochemical hypothyroidism. its occurrence in association with subclinical hypothyroidism is extremely unusual. we describe a patient with subclinical hypothyroidism who developed clinical manifestations of myxedema coma. | 2010 | 21058937 |
| morphological, haemato-biochemical and endocrine changes in young standardbreds with 'maladaptation' to early training. | the demands in the standardbred trotters industry require young, still growing horses, to be trained well above light exercise level. during that period, the risk of occurrence of energy imbalance and maladaptation to training is high. in man, the lack of energy homeostasis is considered as the basic problem in the development of chronic fatigue. | 2010 | 21059002 |
| trapping of palindromic ligands within native transthyretin prevents amyloid formation. | transthyretin (ttr) amyloidosis is a fatal disease for which new therapeutic approaches are urgently needed. we have designed two palindromic ligands, 2,2'-(4,4'-(heptane-1,7-diylbis(oxy))bis(3,5-dichloro-4,1-phenylene)) bis(azanediyl)dibenzoic acid (mds84) and 2,2'-(4,4'-(undecane-1,11-diylbis(oxy))bis(3,5-dichloro-4,1-phenylene)) bis(azanediyl)dibenzoic acid (4ajm15), that are rapidly bound by native wild-type ttr in whole serum and even more avidly by amyloidogenic ttr variants. one to one st ... | 2010 | 21059958 |
| functional roles of the n- and c-terminal regions of the human mitochondrial single-stranded dna-binding protein. | biochemical studies of the mitochondrial dna (mtdna) replisome demonstrate that the mtdna polymerase and the mtdna helicase are stimulated by the mitochondrial single-stranded dna-binding protein (mtssb). unlike escherichia coli ssb, bacteriophage t7 gp2.5 and bacteriophage t4 gp32, mtssbs lack a long, negatively charged c-terminal tail. furthermore, additional residues at the n-terminus (notwithstanding the mitochondrial presequence) are present in the sequence of species across the animal king ... | 2010 | 21060847 |
| injections of clostridium botulinum neurotoxin a may cause thyroid complications in predisposed persons based on molecular mimicry with thyroid autoantigens. | a woman with hashimoto's thyroiditis, under replacement l-t4, repeatedly experienced, over a 10-year period, elevations of serum tsh after eyelid injections of clostridium botulinum neurotoxin a (btx). we hypothesized a link between btx injections and tsh elevations via molecular mimicry, and aimed to verify our hypothesis. using an in silico approach, we searched first for amino acid sequence homology between btx and thyroid autoantigens, and next for hla binding motifs within homologous segmen ... | 2011 | 21061092 |
| prognostic significance of replication protein a (rpa) expression levels in bladder urothelial carcinoma. | objective: • to elucidate the role of replication protein a (rpa) in both superficial (ta-t1) and muscle-invasive (t2-t4) urothelial carcinomas (ucs), investigating its potential prognostic usefulness. patients and methods: • paraffin-embedded tissue from 156 patients with bladder uc was immunostained for rpa1 and rpa2. results: • rpa1 and rpa2 labelling indexes (lis) decreased with increasing histological grade (both p < 0.001) and t-category in the entire cohort (p= 0.008 and p < 0.001, respec ... | 2010 | 21062395 |
| efficient assembly of very short oligonucleotides using t4 dna ligase. | abstract: | 2010 | 21062485 |
| engineered split in pfu dna polymerase fingers domain improves incorporation of nucleotide gamma-phosphate derivative. | using compartmentalized self-replication (csr), we evolved a version of pyrococcus furiosus (pfu) dna polymerase that tolerates modification of the γ-phosphate of an incoming nucleotide. a q484r mutation in α-helix p of the fingers domain, coupled with an unintended translational termination-reinitiation (split) near the finger tip, dramatically improve incorporation of a bulky γ-phosphate-o-linker-dabcyl substituent. whether synthesized by coupled translation from a bicistronic (-1 frameshift) ... | 2010 | 21062827 |
| extended surgery and pelvic exenteration for locally advanced rectal cancer. what are the limits? | historically, locally advanced rectal cancers with invasion of tumor into adjacent organs (t4 n1, 2 tumors) have been considered poor prognosis cancers treated with palliative intent. however with the advent of multi-modality therapy and improvement in surgical reconstructive techniques, extended resections for rectal tumors are possible with acceptable patient morbidity and excellent oncological outcomes. | 2010 | 21066979 |
| the traf-interacting protein (trip) is a regulator of keratinocyte proliferation. | the traf-interacting protein (trip/traip) is a ring-type e3 ubiquitin ligase inhibiting tumor necrosis factor-α (tnf-α)-mediated nf-κb activation. trip ablation results in early embryonic lethality in mice. to investigate trip function in epidermis, we examined its expression and the effect of trip knockdown (kd) in keratinocytes. trip mrna expression was strongly downregulated in primary human keratinocytes undergoing differentiation triggered by high cell density or high calcium. short-term ph ... | 2010 | 21068752 |
| cognitive decrements do not follow neuromuscular alterations during passive heat exposure. | to investigate what triggers cognitive and neuromuscular alterations during passive heat exposure, eight volunteers performed simple (one touch stockings of cambridge, ots-4) and complex (ots-6) cognitive tasks as well as neuromuscular testing (maximal isometric voluntary contractions of the thumb with electrical stimulation of the motor nerve and magnetic stimulation of the motor cortex). these tests were performed at the start (t1), after 1 h 30 min (t2), 3 h (t3) and 4 h 30 min (t4) of exposu ... | 2010 | 21070138 |
| thyroid hormones are positively associated with insulin resistance early in the development of type 2 diabetes. | thyroid hormones have generally been found normal in diabetic patients. the question of whether variation within the euthyroid range influences insulin sensitivity in type 2 diabetes remains to be established. to investigate this, a meal was given to four groups: 17 healthy volunteers (controls), 22 first-degree relatives of type 2 diabetic subjects (relatives), 15 subjects with impaired glucose tolerance (igt), and 24 subjects with overt type 2 diabetes (dm). blood was drawn for 360 min for mea ... | 2010 | 21072691 |
| patterns of lymph node metastasis are different in colon and rectal carcinomas. | to describe patterns of lymph node metastasis in invasive colon and rectal carcinomas. | 2010 | 21072903 |
| [transthyretin-binding activity of hexabromocyclododecanes (hbcds) and its thyroid hormone disrupting effects after developmental exposure]. | in vivo and in vitro research approaches were carried out to survey the potential health risk of environmental exposure by hexabromocyclododecanes (hbcds). transthyretin-binding assay was designed to test for the potency of hbcds to compete with thyroxine (t4) for binding to the transport protein. the results showed that the binding of 25i-t4 and t4 was only slightly inhabited even at the highest competitive concentration of hbcds (75.08%, 80 micromol x l(-1)), indicating the marginally interfer ... | 2010 | 21072945 |
| detecting coupled collective motions in protein by independent subspace analysis. | protein dynamics evolves in a high-dimensional space, comprising aharmonic, strongly correlated motional modes. such correlation often plays an important role in analyzing protein function. in order to identify significantly correlated collective motions, here we employ independent subspace analysis based on the subspace joint approximate diagonalization of eigenmatrices algorithm for the analysis of molecular dynamics (md) simulation trajectories. from the 100 ns md simulation of t4 lysozyme, w ... | 2010 | 21073231 |
| prognostic factors for survival after curative resection of dukes' b colonic cancer. | aim data on the prognostic factors for survival in patients with locally advanced, node-negative colon cancer are limited. this study aimed to determine which factors might predict survival in patients with dukes' b (t3 or t4, n0) colon cancer. method 180 (males 93; median age 75 [range, 38 - 96] years) consecutive patients who had resection of a primary dukes' b (on final histopathological analysis) colonic cancer between 1998 and 2003 were studied. no patient received neoadjuvant chemotherap ... | 2010 | 21073647 |
| algorithm for selection of optimized epr distance restraints for de novo protein structure determination. | a hybrid protein structure determination approach combining sparse electron paramagnetic resonance (epr) distance restraints and rosetta de novo protein folding has been previously demonstrated to yield high quality models (alexander et al. (2008)). however, widespread application of this methodology to proteins of unknown structures is hindered by the lack of a general strategy to place spin label pairs in the primary sequence. in this work, we report the development of an algorithm that optima ... | 2010 | 21074624 |
| details of recurrence sites after elective nodal irradiation (eni) using 3d-conformal radiotherapy (3d-crt) combined with chemotherapy for thoracic esophageal squamous cell carcinoma--a retrospective analysis. | to describe patterns of recurrence of elective nodal irradiation (eni) in definitive chemoradiotherapy (crt) for thoracic esophageal squamous cell carcinoma (sqcc) using 3d-conformal radiotherapy. | 2010 | 21074880 |
| prognostic significance of human apurinic/apyrimidinic endonuclease (ape/ref-1) expression in rectal cancer treated with preoperative radiochemotherapy. | purpose: human apurinic endonuclease/redox factor 1 (ape/ref-1) mediates repair of radiation-induced dna lesions and regulates transcription via redox-based activation. we investigated the predictive and prognostic significance of ape/ref-1 expression in pretreatment biopsy specimens in locally advanced rectal cancer (larc) (ct3-t4 or n+). methods and materials: ape/ref-1 expression was analyzed by immunohistochemistry in pretreatment biopsy specimens obtained from 83 patients with larc. patient ... | 2010 | 21075552 |
| salivary gland tumors treated with adjuvant intensity-modulated radiotherapy with or without concurrent chemotherapy. | purpose: to analyze the recent single-institution experience of patients with salivary gland tumors who had undergone adjuvant intensity-modulated radiotherapy (imrt), with or without concurrent chemotherapy. patients and methods: we performed a retrospective analysis of 35 salivary gland carcinoma patients treated primarily at the dana-farber cancer institute between 2005 and 2010 with surgery and adjuvant imrt. the primary endpoints were local control, progression-free survival, and overall su ... | 2010 | 21075557 |
| case study of hepatic radiofrequency ablation causing a systemic inflammatory response under total intravenous anesthesia. | to investigate the effects of hepatic radiofrequency ablation (rfa) in patients with malignant liver disease with respect to inflammation activation and stress response. | 2010 | 21076590 |
| [the new tnm classification in lung cancer]. | this paper presents the new tnm classification in lung cancer and its history. seventh edition of tumor, node, metastasis (tnm) classification in lung cancer has been published by the international union against cancer (uicc) and the american joint committee on cancer (ajcc) at the beginning of 2009. the changes were based upon the results of the international project of the international association for the study of lung cancer (iaslc). the database included 81.495 patients from the entire worl ... | 2010 | 21077033 |
| the effects of levothyroxine substitution on body composition and body mass after total thyroidectomy for benign nodular goiter. | objective many patients who have undergone total thyroidectomy complain about weight gain and changes in body composition. this prospective study was designed to evaluate the effect of thyroxine replacement on body mass index (bmi) and body composition following total thyroidectomy for benign multinodular goiter.<br />methods thirty-three consecutive patients were enrolled. the patients of those histopathological examination revealed carcinoma (n=5) and who did not present for the 6th month foll ... | 2010 | 21077724 |
| chemically immobilized t4-bacteriophage for specific escherichia coli detection using surface plasmon resonance. | a bioassay platform using t4 bacteriophage (t4) as the specific receptor and surface plasmon resonance (spr) as the transduction technique has been developed for the detection of escherichia coli k12 bacteria. the t4 phages have been covalently immobilized onto gold surfaces using a self-assembled monolayer of dithiobis(succinimidyl propionate) (dtsp). substrates of bsa/ea-t4/dtsp/au prepared using different t4 phage concentrations have been characterized using scanning electron microscopy (sem) ... | 2010 | 21079850 |
| biochemical characterization of bacteriophage t4 mre11-rad50 complex. | the mre11-rad50 complex (mr) from bacteriophage t4 (gp46/47) is involved in the processing of dna double-strand breaks. here, we describe the activities of the t4 mr complex and its modulation by proteins involved in homologous recombination. t4 mre11 is a rad50- and mn(2+)-dependent dsdna exonuclease and ssdna endonuclease. atp hydrolysis is required for the removal of multiple nucleotides via dsdna exonuclease activity but not for the removal of the first nucleotide or for ssdna endonuclease a ... | 2010 | 21081488 |
| [t4 lung cancer: results of surgical treatment]. | stage t4 non small cell lung cancer (nsclc) includes an heterogeneous group of locally advanced tumors. results of surgery alone and of chemo and/or radiotherapy are disappointing with 5-year survival rates under 10%. although palliative chemo-radiotherapy is the treatment of choice in most cases, radical resection has shown prognostic benefit in selected groups of patients with tumor infiltrating superior vena cava, carina, aorta, left atrium and vertebral bodies. completeness of resection and ... | 2010 | 21081868 |
| synthetic symmetrization in the crystallization and structure determination of cela from thermotoga maritima. | protein crystallization continues to be a major bottleneck in x-ray crystallography. previous studies suggest that symmetric proteins, such as homodimers, might crystallize more readily than monomeric proteins or asymmetric complexes. proteins that are naturally monomeric can be made homodimeric artificially. our approach is to create homodimeric proteins by introducing single cysteines into the protein of interest, which are then oxidized to form a disulfide bond between the two monomers. by in ... | 2011 | 21082721 |
| micro open-sandwich elisa to rapidly evaluate thyroid hormone concentration from serum samples. | thyroxine (t4) is the most commonly measured thyroid hormone for the diagnosis of thyroid function. to elucidate a rapid and sensitive assay for t4, we made a microfluidics-based noncompetitive immunodetection chip system using anti-t4 antibody fragments obtained from a phage display library. | 2010 | 21083320 |
| analytical validation of the liaison calcitonin_ii-gen (diasorin). | we validated the diasorin liaison calcitonin_ii-gen, an improved method for calcitonin (ct) measurements, compared this method with the cisbio_h-ct kit and established the reference range of ct in a normal adult population. | 2010 | 21083442 |
| endoscopic left sympathetic blockade in the treatment for dilated cardiomyopathy. | the level of sympathetic nervous activity is a major determinant of prognosis in patients with heart failure. | 2010 | 21085758 |
| tsh reference values for adult brazilian population. | to establish limits of normal serum tsh for the adult (18 to 60 years) brazilian population according to recommendations of the national academy of clinical biochemistry. | 2010 | 21085764 |
| relationship between thyrotropin and body mass index in euthyroid subjects. | several studies have reported that thyrotropin (tsh) levels are slightly increased in obese subjects. on the contrary, other studies have provided no evidence for an association between thyroid status and body mass index (bmi). | 2010 | 21086247 |
| radical prostatectomy for ct3-4 disease: an evaluation of the pathological outcomes and patterns of care for adjuvant radiation in a national cohort. | study type - therapy (cohort) level of evidence 2b objective: to use the surveillance, epidemiology and end results database to evaluate the pathological outcomes for patients with clinically staged t3-4 disease who undergo radical prostatectomy and to analyze whether these patients are receiving adjuvant radiation. materials and methods: we identified patients who were clinically staged as having t3-4n0m0 prostate cancer and underwent radical prostatectomy between 2004 and 2006. clinical data r ... | 2010 | 21087395 |
| t4 virus-based toolkit for the direct synthesis and 3d organization of metal quantum particles. | one of the challenges in building superstructures based on small metal particles is producing stable interparticle separation. herein, we present a novel assembly method based on the use of the t4 bacteriophage capsid as a scaffold for the construction of 3d monodisperse metal-particle arrays. the highly regular and symmetrical protein surface of the t4 capsid allows the site-directed adsorption and subsequent reduction of metal ions, thus permitting the growth of metal particles in situ to enab ... | 2010 | 21089036 |
| expression of matrix metalloproteinase-9 mrna and vascular endothelial growth factor protein in gastric carcinoma and its relationship to its pathological features and prognosis. | to investigate matrix metalloproteinase-9 (mmp-9) mrna and vascular endothelial growth factor (vegf) protein expression in gastric carcinoma and its correlation with microvascular density, growth-pattern, invasion, metastasis, and prognosis. in situ hybridization of mmp-9 mrna and immunohistochemistry of vegf and cd34 proteins were performed on surgical specimens of gastric cancers from 118 patients compared with 20 nonmalignant gastric mucosae. their relationships to pathological parameters and ... | 2010 | 21089052 |
| functional cationic nanomagnet-porphyrin hybrids for the photoinactivation of microorganisms. | cationic nanomagnet-porphyrin hybrids were synthesized and their photodynamic therapy capabilities were investigated against the gram (-) escherichia coli bacteria, the gram (+) enterococcus faecalis bacteria and t4-like phage. the synthesis, structural characterization, photophysical properties, and antimicrobial activity of these new materials are discussed. the results show that these new multicharged nanomagnet-porphyrin hybrids are very stable in water and highly effective in the photoinact ... | 2010 | 21090642 |
| swnt-mwnt hybrid filter attains high viral removal and bacterial inactivation. | we describe the concept and demonstrate the efficacy of a novel swnt-mwnt hybrid filter for the removal and inactivation of microbial pathogens from water. the filter is composed of a thin swnt layer (0.05 mg cm(-2)) on top of a thicker mwnt layer (0.27 mg cm(-2)) supported by a microporous support membrane. the swnt-mwnt filter exhibits high log removal of several model viruses (ms2, prd1, and t4 bacteriophages) by depth filtration, which predominantly takes place in the thicker and more unifor ... | 2010 | 21090770 |
| pulsatile flow improves cerebral blood flow in pediatric cardiopulmonary bypass. | the objective of this study was to evaluate the effect of pulsatile flow on cerebral blood flow (cbf) in infants with the use of a mild hypothermic cardiopulmonary bypass (cpb). thirty infants scheduled for open heart surgery were randomized to the pulsatile group (group p, n = 15) and nonpulsatile group (group np, n = 15). in group p, pulsatile perfusion was applied during the aortic cross-clamping period, whereas nonpulsatile perfusion was used in group np. the systolic peak velocity (vs), the ... | 2010 | 21092029 |
| lung cancer invading the pericardium: quantum of lymph nodes. | lung cancer may invade the pericardium (t3) and the intrapericardial pulmonary veins and left atrium (t4). our purpose was to analyze the characteristics of this invading process in search of the reasons explaining its poor prognosis. | 2010 | 21095307 |
| effects of a soybean protein diet on ovariectomised female albino rats subjected to myocardial infarction. | cardiovascular disease is the leading cause of death among menopausal women in developed countries, mostly due to the loss of endogenous oestrogen protection. soybean protein (sp) is rich in isoflavone phytoestrogens. this study aimed to determine the effect of sp on ovariectomised rats subjected to myocardial infarction and its possible cardio-protection. | 2010 | 21103813 |
| the impact of ogg1, mth1 and mnsod gene polymorphisms on 8-hydroxy-2'-deoxyguanosine and cellular superoxide dismutase activity in myocardial ischemia-reperfusion. | ischemia-reperfusion (i/r) injury, by inducing oxidative dna damage, is one of the leading causes of increased patient morbidity and mortality in coronary artery by-pass grafting (cabg) surgery. 8-hydroxyguanine (8-ohg) is an important oxidative base lesion. the 8-oxoguanine glycosylase (hogg1) and hmth1, which have several polymorphisms, remove 8-ohdg from the nucleotide pool. we investigated whether there are any correlations the biomarkers of oxidative stress (superoxide dismutase; sod and 8- ... | 2010 | 21104149 |
| sonographic assessment of congenitally hypothyroid children in iran. | considering the high prevalence of congenital hypothyroidism (ch) in isfahan, it seems that it is necessary to investigate the aetiology of the disorder and its related factors. the aim of this study was to determine the aetiology of ch among children in isfahan province. | 2010 | 21104640 |
| negative associations between pbde levels and thyroid hormones in cord blood. | polybrominated diphenyl ethers (pbdes) causing thyroidal effects have been demonstrated in in vivo and in vitro studies. pbdes with structural similarities to thyroid hormones have increased recently, but the health effects for thyroid hormones have not been well studied. the study aimed to determine pbde levels in cord blood and further to explore associations between prenatal pbde exposures and thyroid hormones in cord blood. fifty-four cord blood samples were collected after delivery. cord-bl ... | 2010 | 21106438 |
| oxidative stress elevated dna damage and homocysteine level in normal pregnant women in a segment of pakistani population. | maternal oxidative stress during pregnancy may impair fetal growth and help in the development of diseases in adulthood. the aim of current study was to assess total oxidation status (tos), related parameters and their relationship to dna damage (%) and homocysteine level in normal pregnant women in low-income participants. in a cross-sectional study healthy women were grouped as normal, while age matched nulliparous and singleton pregnancies were included for first, second and third trimester g ... | 2010 | 21107731 |
| comparison of the 6th and 7th editions of the uicc tnm staging system for gastric cancer: results of a chinese single-institution study of 1,503 patients. | to evaluate the prognostic efficacy of the 7th edition tumor-node-metastasis (tnm) classification compared with the 6th edition in gastric cancer patients. | 2010 | 21107742 |
| comparison of propofol and etomidate anaesthesia for elective electrical cardioversion. | propofol has been previously shown to be superior to etomidate during electrical cardioversion (ec) of atrial tachyarrhythmias. however, literature on this topic is scarce and the optimal anaesthetic technique for ec has not yet been firmly established. | 2010 | 21108204 |
| oral squamous cell carcinoma detection by salivary biomarkers in a serbian population. | early detection of oral squamous cell cancer (oscc) is the key to improve the low 5-year survival rate. using proteomic and genomic technologies we have previously discovered and validated salivary oscc markers in american patients. the question arises whether these biomarkers are discriminatory in cohorts of different ethnic background. six transcriptome (dusp1, il8, il1b, oaz1, sat1, and s100p) and three proteome (il1b, il8, and m2bp) biomarkers were tested on 18 early and 17 late stage oscc p ... | 2010 | 21109482 |
| regulation by interdomain communication of a headful packaging nuclease from bacteriophage t4. | in genome packaging by tailed bacteriophages and herpesviruses, a concatemeric dna is cut and inserted into an empty procapsid. a series of cuts follow the encapsidation of each unit-length 'headful' genome, but the mechanisms by which cutting is coupled to packaging are not understood. here we report the first biochemical characterization of a headful nuclease from bacteriophage t4. our results show that the t4 nuclease, which resides in the c-terminal domain of large 'terminase' gp17, is a wea ... | 2010 | 21109524 |
| utility of the novel bladder preservation therapy, boai-cddp-radiation (omc-regimen), for elderly patients with invasive bladder cancer. | in this study, we investigated the novel bladder preservation therapy, the balloon-occluded arterial infusion (boai) of cisplatin/gemcitabine, concomitantly with hemodialysis, along with concurrent irradiation [the 'osaka medical college (omc)-regimen'] in patients >70 years of age with muscle-invasive bladder cancer. eighty-three such patients were assigned to receive either the omc-regimen (n=56) or cystectomy (n=27). the omc-regimen patients who failed to achieve complete response (cr) underw ... | 2011 | 21109921 |
| [speech intelligibility degree and coping after multimodal therapy of oral squamous carcinoma]. | multimodal treatment of oral cancer can cause speech disorders and diminish speech intelligibility. speech intelligibility is an essential part of social interaction and therefore important for coping with the disease. the aim of this study was to investigate the influence of speech intelligibility on coping strategies and a standardized questionnaire. | 2010 | 21110292 |
| acute fluid shifts influence the assessment of serum vitamin d status in critically ill patients. | recent reports have highlighted the prevalence of vitamin d deficiency and suggested an association with excess mortality in critically ill patients. serum vitamin d concentrations in these studies were measured following resuscitation. it is unclear whether aggressive fluid resuscitation independently influences serum vitamin d. | 2010 | 21110839 |
| reduced plasma glucose and leptin after 12 weeks of functional electrical stimulation-rowing exercise training in spinal cord injury patients. | to investigate the effects of exercise training with a functional electrical stimulation (fes) rowing machine on insulin resistance, plasma leptin levels, and body composition in people with spinal cord injury (sci). | 2010 | 21112441 |
| radical esophagectomy for esophageal cancer: results in thai patients. | radical esophagectomy was reported to have prolonged survival in patients with esophageal cancer however, it is associated with high morbidity and mortality. controversy still exists regarding value of radical esophagectomy | 2010 | 21114203 |
| effects of partially replacing barley or corn with raw and micronised cdc so-i oats on productive performance of lactating dairy cows. | recently, a new genotype of oat (cv. cdc so-i, containing low-hull lignin and high-fat groat), has been developed. the objective of this study was to determine the effects of partially replacing barley and corn with the new oat and its micronisation on lactating performance of dairy cows. in a double 4 x 4 latin square design, eight lactating dairy cows (732 +/- 46 kg body weight [bw]; parity 4 +/- 2) received total mixed rations with a forage-to-concentrate ratio of 50:50 (dm basis). the four t ... | 2010 | 21114237 |
| relationships between thyroid function and lipid status or insulin resistance in a pediatric population. | in adults without thyroid disease, increasing levels of thyroid-stimulating hormone (tsh) within the range of that considered normal have been shown to be associated with increases in total cholesterol, low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and triglycerides, and with decreases in high-density lipoprotein cholesterol. serum tsh has also been found to be positively associated with fasting and postload insulin concentrations and negatively associated with i ... | 2010 | 21114382 |
| defunctioning stomas prior to chemoradiation for anal cancer are usually permanent. | aim: a few patients with anal cancer will require a defunctioning stoma prior to chemoradiotherapy (crt). the purpose of this retrospective review was to determine whether the frequency with which a pretreatment stoma was subsequently reversed. method: between 1997 and 2007 46/344 patients treated, 35 with curative intent, for anal cancer underwent a defunctioning stoma prior to crt. results: of the 35 patients, 16 patients had t4,, 17 t3 and 2 t2 disease. sixteen were node positive. the aver ... | 2010 | 21114753 |
| [survival analysis of completely resected stage iiib non-small cell lung cancer.] | background: most stage iiib (t4/n3) non-small cell lung cancer (nsclc) can not be cured via operation, but how is the outcome for those with t4 or occasionally n3 which can be completely resected? this paper retrospectively analyses the effects of the tumor characteristics and postoperative treatments on the survival of 51 patients with stage iiib nsclc completely resected in this hospital from january 1, 1997 to april 30, 2001. methods: the effects of clinical pathophysiological characteristics ... | 2007 | 21114931 |
| the binding energy distribution analysis method (bedam) for the estimation of protein-ligand binding affinities. | the binding energy distribution analysis method (bedam) for the computation of receptor-ligand standard binding free energies with implicit solvation is presented. the method is based on a well established statistical mechanics theory of molecular association. it is shown that, in the context of implicit solvation, the theory is homologous to the test particle method of solvation thermodynamics with the solute-solvent potential represented by the effective binding energy of the protein-ligand co ... | 2010 | 21116484 |
| rotamer libraries of spin labelled cysteines for protein studies. | studies of structure and dynamics of proteins using site-directed spin labelling rely on explicit modelling of spin label conformations. the large computational effort associated with such modelling with molecular dynamics (md) simulations can be avoided by a rotamer library approach based on a coarse-grained representation of the conformational space of the spin label. we show here that libraries of about 200 rotamers, obtained by iterative projection of a long md trajectory of the free spin la ... | 2010 | 21116569 |
| the optimal oblique angle of fluoroscope for thoracic sympathetic ganglion block. | the target in the thoracic sympathetic ganglion block (tsgb) is the anterior edge of the costovertebral articulation along the lateral surface of vertebral bodies t2-4. the present study attempts to determine an optimal safe angle for fluoroscopy in fluoroscope-assisted tsgb through the use of chest ct scan images. additionally, we seek to determine if differences in these measurements exist in patients with chronic obstructive pulmonary disease (copd). | 2010 | 21116677 |
| effect of agropesticides use on male reproductive function: a study on farmers in djutitsa (cameroon). | this study aimed at investigating the effect of agropesticides on male reproductive function in farmers in djutitsa (west cameroon). to this end, 47 farmers in djutitsa were asked questions on their health status and pesticide use in agriculture. thereafter, their blood samples were collected for assessment of sex hormones including serum luteinizing hormone (lh), follicle-stimulating hormone (fsh), androstenedione, testosterone, as well as sex hormone binding globulin (shbg). their serum triiod ... | 2010 | 21117141 |
| treatment of n in the upper maxillary tumors. | from 2002 to 2008, 86 patients have undergone surgical treatment of malignant upper maxillary tumors at the maxillo-facial surgery department, tor vergata university, rome. all the n-positive patients at the time of the t therapy have undergone lymph node surgical emptying. in 6 patients, a laterocervical emptying was performed when laterocervical metastases were found. in the remaining 68 patients, with no evidence of n, we did not perform laterocervical emptying. we found in our patients a hig ... | 2010 | 21119424 |
| lymph node ratio provides prognostic information in addition to american joint committee on cancer n stage in patients with melanoma, even if quality of surgery is standardized. | to investigate whether lymph node ratio (lnr) gives additional prognostic information to american joint committee on cancer (ajcc) n stage in a melanoma treatment center where regional lymph node dissection (rlnd) techniques are standardized. | 2011 | 21119509 |
| an anatomical study in a chinese population of the position of the rib head for placing anterior vertebral body screws. | the instrumentation of anterior vertebral body screws has become an important approach for the treatment of unstable fractures or curvature of the spine, but little attention has been paid to the starting point of placing the screws and the variability of the rib head position. we analysed the variability of rib head position in a chinese population in terms of the spinal canal and vertebral body using computed tomography (ct). images from transverse ct scans of the t4-t12 vertebral bodies of 30 ... | 2010 | 21120810 |
| thyroid storm in a patient with fulminant hepatic failure. | this manuscript describes a 28-year-old patient with a history of graves' disease who was transferred to tulane university hospital with fulminant hepatic failure. he reported associated nausea, vomiting, anorexia, as well as jaundice and abdominal discomfort for a period of 3 weeks prior to his admission. his thyroid function tests on admission were tsh, 0.013 μu/ml; t3, 94.9 μu/ml; t4, 9.37 μu/ml; free t4, >6 μu/ml. his liver function tests were characteristic of hepatic failure. the patient u ... | 2011 | 21120833 |
| local response to chemoradiation in t4 larynx cancer with cartilage invasion. | patients with cartilage invasion were excluded from organ preservation protocols treating laryngeal and hypopharyngeal cancer. treatment choice between chemoradiotherapy (crt) and total laryngectomy (tl) remains controversial for these patients. | 2011 | 21120838 |
| [lymphadenectomy in papillary thyroid cancer]. | papillary carcinoma is the most frequent malign tumour of the thyroid with rising incidence and metastasising in lymphatic veins. | 2010 | 21121153 |
| a study on prevalence of thyroid auto-immunity in type 1 diabetes mellitus. | type 1 diabetes mellitus is an auto-immune disease. it is associated with other auto-immune endocrine disorders and auto-immune impairment of non-endocrine tissue. auto-immune thyroid disease is one of the most frequent auto-immune diseases associated with it. hypothyroidism can decrease insulin requirement in such patients and hyperthyroidism may cause glucose intolerance. this study attempts to review this concept and detect overt and subclinical forms of auto-immune thyroid disease in type 1 ... | 2010 | 21121384 |
| bacterial secretion chaperones. | many gram-negative bacteria are able to invade hosts by translocation of effectors directly into target cells in processes usually mediated by two very complex secretion systems (sss), named type iii (t3) and type iv (t4) sss. these syringe-needle injection devices work with intervention of specialized secretion chaperones that, unlike traditional molecular chaperones, do not assist in protein folding and are not energized by atp. controversy still surrounds secretion chaperones primary role, bu ... | 2011 | 21121896 |
| a strategic approach for tongue reconstruction to achieve predictable and improved functional and aesthetic outcomes. | successful tongue reconstruction should restore swallowing, speech function, and cosmesis. the purpose of this prospective study was to evaluate the functional and aesthetic outcomes of tongue reconstruction using variable free flaps based on different tongue defects. | 2010 | 21124135 |
| specificity of interactions among the dna-packaging machine components of t4-related bacteriophages. | tailed bacteriophages use powerful molecular motors to package the viral genome into a preformed capsid. packaging at a rate of up to ∼2000 bp/s and generating a power density twice that of an automobile engine, the phage t4 motor is the fastest and most powerful reported to date. central to dna packaging are dynamic interactions among the packaging components, capsid (gp23), portal (gp20), motor (gp17, large "terminase"), and regulator (gp16, small terminase), leading to precise orchestration o ... | 2010 | 21127059 |
| long-term aspirin use and the risk of total, high-grade, regionally advanced and lethal prostate cancer in a prospective cohort of health professionals, 1988-2006. | experimental studies suggest a role for aspirin in the chemoprevention of prostate cancer and epidemiological evidence supports a modest inverse association between regular aspirin use and prostate cancer risk, especially for advanced disease. in a prospective cohort study of 51,529 health professionals aged 40-75 years at baseline, we evaluated long-term aspirin use and the incidence of total, high-grade (gleason 8-10, n = 488), regionally advanced (t3b-t4 or n1, n = 228) and lethal prostate ca ... | 2011 | 21128233 |
| prevalence of hyperthyroidism after exposure during childhood or adolescence to radioiodines from the chornobyl nuclear accident: dose-response results from the ukrainian-american cohort study. | relatively few data are available on the prevalence of hyperthyroidism (tsh concentrations of <0.3 miu/liter, with normal or elevated concentrations of free t4) in individuals exposed to radioiodines at low levels. the accident at the chornobyl (chernobyl) nuclear plant in ukraine on april 26, 1986 exposed large numbers of residents to radioactive fallout, principally to iodine-131 ((131)i) (mean and median doses = 0.6 gy and 0.2 gy). we investigated the relationship between (131)i and prevale ... | 2010 | 21128800 |
| changes in kinematics and trunk electromyography during a 2000 m race simulation in elite female rowers. | achieving excellence in rowing requires optimization of technique to maximize efficiency and force production. investigation of the kinematics of the trunk, upper and lower extremity, together with muscle activity of the trunk, provides an insight into the motor control strategies utilized over a typical race. nine elite female rowers performed a 2000 m race simulation. kinematic data of the trunk and extremities, together with electromyography (emg) activity of spinal and pelvic extensor and fl ... | 2010 | 21129036 |
| the prognosis of tumors with only microscopic skin involvement without clinical t4b signs is significantly better than t4b tumors in breast carcinoma. | the number of studies forming a base for tumor (t)-node (n)-metastasis (m) classification by comparing t4b tumors with only histological skin involvement in breast carcinoma is limited and results are contradictory. in this study, the survival of patients with t4b tumor and patients whose tumor had only microscopic skin involvement without clinical t4b signs were compared. the file records of 101 patients with t4b tumor (group a) and 79 patients whose tumor had only microscopic skin involvement ... | 2010 | 21129094 |
| morphogenesis of the t4 tail and tail fibers. | remarkable progress has been made during the past ten years in elucidating the structure of the bacteriophage t4 tail by a combination of three-dimensional image reconstruction from electron micrographs and x-ray crystallography of the components. partial and complete structures of nine out of twenty tail structural proteins have been determined by x-ray crystallography and have been fitted into the 3d-reconstituted structure of the "extended" tail. the 3d structure of the "contracted" tail was ... | 2010 | 21129200 |