Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| surgical correction of spinal deformity in patients with congenital muscular dystrophy. | congenital muscular dystrophy (cmd), among the myopathic disorders is one form of flaccid neuromuscular disorder (nmd). patients with nmd frequently develop progressive spinal deformity. for nmd patients who have a severe spinal deformity, sitting is often difficult and is accompanied by pain and breakdown of the skin. spinal deformity surgery in these patients has been highly effective in stabilizing the spine, maintaining upright, comfortable sitting balance, and improving patients' quality of ... | 2010 | 20721717 |
| screening for thyroid disease | this article focuses on whether it is useful to order a thyroid function test in patients who have no history of thyroid disease and have few or no signs or symptoms of thyroid dysfunction. | 2004 | 20722119 |
| nonsurgical innovations in the treatment of nonmelanoma skin cancer. | basal cell carcinoma and squamous cell carcinoma are the most frequent types of cancer in the united states and represent 75 percent and 20 percent, respectively, of all nonmelanoma skin cancers. since ultraviolet radiation is implicated in their development, photoprotection is fundamental in their prevention. additional preventive measures include identifying high-risk individuals for early detection along with using agents, such as retinoids, that are effective in decreasing the risk of premal ... | 2010 | 20725548 |
| cranio-thoracic bullet migration over a period of 27 years: case report. | we report the case of a 36 year old woman that was hurt in the head with a lost bullet while walking through the street when she was 9 years old. on admission, the patient was fully conscious with no neurological deficits. skull radiography showed the intracranial bullet but she was dispatched after 24 hours of observation without neurological deterioration. six months later she suddenly presented quadriplegia and after one year of rehabilitation she recovered the mobility and strength in all he ... | 2010 | 20725703 |
| anastomotic leak rate after low anterior resection for rectal cancer after chemoradiation therapy. | anastomotic leak may be the most concerning complication after colorectal anastomosis. to compare open with laparoscopic rectal resection, we must have accurate leak rates in patients who have received neoadjuvant chemoradiation therapy to serve as a benchmark for comparison. all patients who had preoperative chemoradiation therapy with rectal resection and low pelvic anastomosis for cancer in a single colorectal practice over a 7-year period were retrospectively reviewed. all patients had proxi ... | 2010 | 20726419 |
| combination of dna ligase reaction and gold nanoparticle-quenched fluorescent oligonucleotides: a simple and efficient approach for fluorescent assaying of single-nucleotide polymorphisms. | a new fluorescent sensing approach for detection of single-nucleotide polymorphisms (snps) is proposed based on the ligase reaction and gold nanoparticle (aunps)-quenched fluorescent oligonucleotides. the design exploits the strong fluorescence quenching of aunps for organic dyes and the difference in noncovalent interactions of the nanoparticles with single-stranded dna (ssdna) and double-stranded dna (dsdna), where ssdna can be adsorbed onto the surface of aunps while dsdna cannot be. in the a ... | 2010 | 20726510 |
| inverse expression of estrogen receptor-beta and nuclear factor-kappab in urinary bladder carcinogenesis. | to investigate the expression of nuclear factor-kappab (nf-kappab) and estrogen receptor-beta (er-beta) signalling pathways in bladder urothelial carcinoma according to clinicopathological features, in order to elucidate their role during carcinogenesis. | 2010 | 20727050 |
| implications of overweight in gastric cancer: a multicenter study in a western patient population. | the purpose of this study was to evaluate the effects of overweight on surgical and long-term outcomes in a western population of patients with gastric cancer (gc). | 2010 | 20727706 |
| a mutation within the β subunit of escherichia coli rna polymerase impairs transcription from bacteriophage t4 middle promoters. | during infection of escherichia coli, bacteriophage t4 usurps the host transcriptional machinery, redirecting it to the expression of early, middle, and late phage genes. middle genes, whose expression begins about 1 min postinfection, are transcribed both from the extension of early rna into middle genes and by the activation of t4 middle promoters. middle-promoter activation requires the t4 transcriptional activator mota and coactivator asia, which are known to interact with σ(70), the specifi ... | 2010 | 20729353 |
| locally advanced thyroid cancer: can ct help in prediction of extrathyroidal invasion to adjacent structures? | the purpose of this study was to determine the diagnostic accuracy of ct for detecting extrathyroidal invasion of thyroid cancer to adjacent structures. | 2010 | 20729422 |
| redox regulation of myocardial erk 1/2 phosphorylation in experimental hyperthyroidism: role of thioredoxin-peroxiredoxin system. | the present study was conducted to test whether adaptation in the antioxidant system would differentially modulate prosurvival and proapoptotic proteins in hyperthyroidism-induced cardiac hypertrophy. male wistar rats were divided into 4 groups: control, vitamin e (20 mg · kg(-1) · d(-1) subcutaneously, 28 days), thyroxine (t4) (12 mg/l in drinking water for 28 days), and t4 + vitamin e. cardiac mass, redox ratio, glutathione peroxidase (gpx) and glutathione reductase (gr) activities, nf-e2-rela ... | 2010 | 20729758 |
| thyroid hormone can favorably remodel the diabetic myocardium after acute myocardial infarction. | it has been previously shown that regulators of physiological growth such as thyroid hormone (th) can favorably remodel the post ischaemic myocardium. here, we further explored whether this effect can be preserved in the presence of co-morbidities such as diabetes which accelerates cardiac remodeling and increases mortality after myocardial infarction. acute myocardial infarction (ami) was induced by left coronary ligation in rats with type i diabetes (dm) induced by streptozotocin administratio ... | 2010 | 20730619 |
| use of primary canine thyroid monolayer cultures to investigate compounds that are thyrotoxic in vivo. | the identification of the mechanism of action of thyroid effects is important in safety evaluation. accordingly, primary cultures of dog thyroid follicular cells have been used to establish a method of identifying whether compounds act directly on thyroid function. the parameters measured are the uptake and incorporation into thyroglobulin of [(125)i] inorganic iodide and the release of the thyroid hormones triiodothyronine (t3) and thyroxine (t4), determined by radioimmunoassay. drugs, such as ... | 1991 | 20732040 |
| response of eucalyptus camaldulensis to irrigation with the hudiara drain effluent. | a pot experiment was conducted to evaluate the effects of the industrial effluent of the hudiara drain on the growth and element accumulation by eucalyptus camaldulensis at early growth stage. plants were irrigated for 18 months with effluent diluted with tap water at 0% (t0), 25% (t1), 50% (t2), 75% (t3), and 100% effluent (t4). results showed that the maximum growth in terms of stem height (260 cm), number of branches (29), stem fresh weight (436.67 g), stem dry weight (203.33 g), total seedli ... | 2010 | 20734912 |
| gigantic two-photon absorption cross sections and strong two-photon excited fluorescence in pyrene core dendrimers with fluorene/carbazole as dendrons and acetylene as linkages. | we report a series of stiff dendrimers (referred to as t1, t2, t3, and t4) that have both gigantic two-photon absorption (tpa) cross sections up to 25,000 gm and strong two-photon excited fluorescence (tpef) with fluorescence quantum yield of ∼0.5. the large tpa cross sections and high quantum yields of these dendrimers are directly related to their geometrical structures, where the polycyclic aromatic pyrene is chosen as the chromophoric core because of its planar and highly π-conjugated struct ... | 2010 | 20735053 |
| virus silicification under simulated hot spring conditions. | silicification of organisms in silica-depositing environments can impact both their ecology and their presence in the fossil record. although microbes have been silicified under laboratory and environmental conditions, viruses have not. bacteriophage t4 was successfully silicified under laboratory conditions that closely simulated those found in silica-depositing hot springs. virus morphology was maintained, and a clear elemental signature of phosphorus was detected by energy-dispersive x-ray sp ... | 2010 | 20735248 |
| novel zeb1 expression in bladder tumorigenesis. | what's known on the subject? and what does the study add? epithelial-mesenchymal transition (emt) is involved in tumor progression where the underlying cellular changes associated with emt have been identified in in vitro models and confirmed in a limited number of in vivo studies. zeb1, which targets e-cadherin repression, is a transcriptional regulator that has been implicated in emt, and is associated with uterine and colorectal cancers. regulation of zeb1 expression has been shown to involve ... | 2011 | 20735391 |
| molecular alterations in key-regulator genes among patients with t4 breast carcinoma. | prognostic factors in patients who are diagnosed with t4 breast carcinomas are widely awaited. we here evaluated the clinical role of some molecular alterations involved in tumorigenesis in a well-characterized cohort of t4 breast cancer patients with a long follow-up period. | 2010 | 20735841 |
| contemporary management of sinonasal cancer. | background.: sinonasal cancer is a relatively uncommon entity encountered by head and neck oncologists, rhinologists, and skull base surgeons. recent innovations in surgical and nonsurgical therapeutic modalities raise the question of whether there has been any measurable improvement for treatment outcomes. methods.: a retrospective review of data from recent studies that focus on surgery, radiation, and chemotherapy, or combinations thereof, was conducted. results.: surgery continues to be the ... | 2010 | 20737500 |
| evaluation of the seventh american joint committee on cancer/international union against cancer classification of gastric adenocarcinoma in comparison with the sixth classification. | the seventh tnm staging system for gastric cancer of the american joint committee on cancer/international union against cancer (ajcc/uicc) had a more detailed classification than the sixth tnm staging system for both the tumor (t) and lymph nodes (n). the authors compared survival rates assessed by the seventh staging system with those by the sixth system. | 2010 | 20737569 |
| complete mapping of glomeruli based on sensory nerve branching pattern in the primary olfactory center of the cockroach periplaneta americana. | glomeruli are structural and functional units in the primary olfactory center in vertebrates and insects. in the cockroach periplaneta americana, axons of different types of sensory neurons housed in sensilla on antennae form dorsal and ventral antennal nerves and then project to a number of glomeruli. in this study, we identified all antennal lobe (al) glomeruli based on detailed innervation patterns of sensory tracts in addition to the shape, size, and locations in the cockroach. the number of ... | 2010 | 20737592 |
| thyroid hormones profile in students of makerere college of health sciences in kampala uganda. | serum concentrations of thyroxine (t4), triiodothyronine (t3) and thyroid stimulating hormone (tsh) are used to assess thyroid function. it is recommended that each laboratory or hospital should establish its own reference values of t4, t3 and tsh for their clients because these hormones vary with ethnicity, geographical and climatic conditions of a population. there is no documented study which has been done to determine the thyroid hormones profile in ugandan general population. this study is ... | 2010 | 20737825 |
| [detection of cea mrna on non-small lung cancer and it's significance.]. | in recent years, many studies on micrometastasis in non-small cell lung cancer (nsclc) have been reported, this study is to investigate the effect of operation on micrometastasis from nsclc and evaluate the relation between micrometastasis and clincopathological parameters. | 2008 | 20738920 |
| the effect of milrinone infusion on right ventricular function during coronary anastomosis and early outcomes in patients undergoing off-pump coronary artery bypass surgery. | during coronary anastomosis in off-pump coronary artery bypass surgery (opcab), hemodynamic alternations can be induced by impaired diastolic function of the right ventricle. this study was designed to examine the effect of milrinone on right ventricular function and early outcomes in patients undergoing opcab. | 2010 | 20740213 |
| adhesion pattern and prognosis studies of t4n0m0 colorectal cancer following en bloc multivisceral resection: evaluation of t4 subclassification. | in current tnm stage system, t4 lesions represent a complex group and should be considered to further optimize the classification. this study evaluates the significance of adhesion pattern in t4 subclassification based on prognostic analysis of t4n0m0 colorectal cancer following en bloc multivisceral resection (mvr). prospectively collected data (1992-2004) were analyzed for 278 patients with stage t4n0m0 lesions following mvr for colorectal cancer. patients were divided into inflammatory adhesi ... | 2011 | 20740326 |
| effect of hypothyroidism on postnatal conjunctival development in rats. | to study the conjunctival development in hypothyroid genetically epilepsy-prone rats (geprs) with serum t3 and t4 significantly lower than in normal rats. | 2011 | 20798563 |
| interrelationship of endocrine glands under thermal stress: effect of exogenous glucocorticoids on mineral, enzyme, thyroid hormone profiles and phagocytosis index of indian goats. | the purpose of the investigation was to examine the pineal-adrenal-thyroid-immune axis in female goats under short-term heat stress. the study was conducted to observe the influence of glucocorticoids on biochemical, endocrine profile and non-specific immune response in propranolol treated goats. | 2010 | 20799852 |
| patterns of response after preoperative intensity-modulated radiation therapy and capecitabine/oxaliplatin in rectal cancer: is there still a place for ecoendoscopic ultrasound? | purpose: the main goals of preoperative chemoradiotherapy (chrt) in rectal cancer are to achieve pathological response and to ensure tumor control with functional surgery when possible. assessment of the concordance between clinical and pathological responses is necessary to make decisions regarding alternative conservative procedures. the present study evaluates the patterns of response after a preoperative chrt regimen, and the value of endoscopic ultrasound (eus) in assessing response. method ... | 2010 | 20800389 |
| effect of different doses of un-fractionated green & black tea extracts on thyroid physiology. | tea is a rich source of polyphenolic flavonoids including catechins, which are thought to contribute to the health benefits of it. flavonoids have been reported to have antithyroid and goitrogenic effect. the purpose of this study was to evaluate whether high doses of green and black tea have a harmful effect on thyroid physiology. un-fractionated green and black tea extracts were administered orally to male rats for 30 days at doses of 1.25 g%, 2.5 g% and 5.0 g%. the results showed that green t ... | 2010 | 20801949 |
| surgery and postoperative radiotherapy a valid treatment for advanced oropharyngeal carcinoma. | since 1992 we have prospectively included all head and neck cancer patients in our health region in a departmental based register. our hospital takes care of all head and neck cancer patients in our health region consisting of approximately 1 million people. in 1997, we evaluated the results of the treatment of oropharyngeal cancer in the 1992-1997 period. on the basis of this evaluation, we changed our treatment policy for tonsillar and base of tongue carcinoma. we first changed the treatment f ... | 2011 | 20803151 |
| long-term parental psychological distress among parents of children with a malformation--a prospective longitudinal study. | we previously reported that prenatal diagnosis of malformations is associated with increased parental psychological distress after birth compared to distress in parents with postnatal diagnosis. we have now extended our earlier study to include a long-term follow-up of mothers and fathers 9 years after birth. psychological responses were measured by general health questionnaire (ghq-28), state anxiety inventory (stai-x1), and impact of event scale (ies) in 118 mothers and 100 fathers of 124 chil ... | 2010 | 20803642 |
| reduction of bupivacaine dose in spinal anaesthesia for caesarean section may improve maternal satisfaction by reducing incidence of low blood pressure episodes. | spinal anaesthesia for caesarean section exposes to high incidence of arterial hypotension which can result in maternal and neonatal morbidity. we hypothesized that the reduction of this dose from 10 mg to 7.5 mg would minimize hypotension without altering pain relief. | 2010 | 20803855 |
| can bone loss be reversed by antithyroid drug therapy in premenopausal women with graves' disease? | abstract: | 2010 | 20807449 |
| plasma zinc, copper, and serum thyroid hormones and insulin levels after zinc supplementation followed by placebo in competitive athletes. | intense physical activity is associated with biological adaptations involving hormones and trace elements. zinc supplementation may affect plasma copper concentration, thyroid-stimulating hormone (tsh), thyroid hormones, insulin, and glucose homeostasis, but data in athletes are scarce. the aim of this study was to evaluate in competitive athletes (cyclists, n = 7, 32 +/- 8 years) the effect of zinc supplementation (22 mg/day as zinc gluconate) during 30 days, and discontinuation using placebo ( ... | 2010 | 20809272 |
| [new tnm classification of malignant lung tumours]. | the staging system for lung tumours is now recommended for the classification of both non-small-cell and small-cell lung cancer as well as for carcinoid tumours of the lung. the t classifications have been redefined: t1 has been subclassified as t1a (≤ 2 cm in size) and t1b (> 2-3 cm in size). t2 has been subclassified as t2a (> 3-5 cm in size) and t2b (> 5-7 cm in size). t2 (> 7 cm in size) has been reclassified as t3. multiple tumour nodules in the same lobe have been reclassified from t4 to t ... | 2010 | 20809404 |
| prognostic relevance of bmi-1 expression and autoantibodies in esophageal squamous cell carcinoma. | overexpression of bmi-1 has been observed in a variety of cancers, and it has been suggested to be an independent prognostic marker for the patients. the objective of this study was to determine the level of bmi-1 expression or its autoantibodies in human esophageal squamous cell carcinoma (escc) and to correlate it with clinicopathologic data. | 2010 | 20809956 |
| normal cortisol response on low-dose synacthen (1 microg) test in children with prader willi syndrome. | it has been postulated that central adrenal insufficiency (cai), resulting from hypothalamic dysfunction, may contribute to the increased unexplained death rates in prader willi syndrome (pws). a study using the overnight metyrapone test reported a 60% prevalence of cai in children with pws. we used a low-dose synacthen test to screen for cai in children with pws. | 2010 | 20810574 |
| template-directed ligation of tethered mononucleotides by t4 dna ligase for kinase ribozyme selection. | in vitro selection of kinase ribozymes for small molecule metabolites, such as free nucleosides, will require partition systems that discriminate active from inactive rna species. while nucleic acid catalysis of phosphoryl transfer is well established for phosphorylation of 5' or 2' oh of oligonucleotide substrates, phosphorylation of diffusible small molecules has not been demonstrated. | 2010 | 20811490 |
| waiting time for emergency abdominal surgery in zaria, nigeria. | management of surgical emergencies in nigeria is characterised by mismatch between supply of facilities and demand for care. this study aimed to evaluate the waiting time between presentation at hospital with acute abdominal disease and operative intervention. | 2010 | 20811524 |
| novel bladder preservation therapy for locally invasive bladder cancer: combined therapy using balloon-occluded arterial infusion of anticancer agent and hemodialysis with concurrent radiation. | we investigated the effect of balloon-occluded arterial infusion (boai) of anticancer agent (cisplatin/gemcitabine), used concomitantly with hemodialysis, which delivers an extremely high concentration of anticancer agent to the site of a tumor without systemic adverse effects, along with concurrent radiation (referred to as the omc-regimen) in patients with advanced bladder cancer. one hundred and ninety-two patients were assigned to receive either the omc-regimen (n=96) or total cystectomy (n= ... | 2010 | 20811698 |
| predicting factors of unexpected peritoneal seeding in locally advanced gastric cancer: indications for staging laparoscopy. | the aim of this study is to investigate predictive factors for unexpected peritoneal seeding from clinically resectable advanced gastric cancers to suggest the indications for staging laparoscopy (sl). | 2010 | 20812349 |
| [effect of intravenous lornoxicam at different doses on the immune function in patients undergoing total abdominal hysterectomy]. | to investigate the effect of intravenous lornoxicam (lor) at different doses given preoperatively on the immune function of patients undergoing total abdominal hysterectomy (tah). | 2010 | 20813681 |
| nanopore analysis of tethered peptides. | peptides of 12 amino acids were tethered via a terminal cysteine to mono-, di-, tri-, and tetrabromomethyl-substituted benzene to produce bundles of one to four peptide strands (cy12-t1 to cy12-t4, respectively). the interaction of the bundles with the α-hemolysin pore was assessed by measuring the blockade currents (i) and times (t) at an applied potential of - 50, - 100, and - 150 mv. three types of events could be distinguished: bumping events, with small i and short t where the molecule tran ... | 2010 | 20814890 |
| changes in serum tsh and free t4 during human sleep restriction. | to examine whether recurrent sleep restriction is accompanied by changes in measures of thyroid function. | 2010 | 20815195 |
| a modified plasmid vector pcmv-3tag-lic for rapid, reliable, ligation-independent cloning of polymerase chain reaction products. | here we present a modified vector pcmv-3taq-lic for a rapid, simple, and relatively cheap method to build expression constructs. after being digested by nt.bspqi and ecorv, a lineal vector with specific 11-base single overhangs is obtained. polymerase chain reaction (pcr) products with complementary overhangs are created by building appropriate extensions into the primers and treating them with t4 dna polymerase. the annealing of the insert and the vector is performed in the absence of ligase by ... | 2011 | 20816743 |
| [exploration of the classification of gross tumor volume and pathological staging of esophageal carcinoma]. | using the volume calculating function of treatment planning system of 3dcrt to work out the value of gtv standard classifications and to provide the reference for clinical staging of esophageal carcinoma. | 2010 | 20819484 |
| polyhalogenated aromatic hydrocarbons and metabolites: relation to circulating thyroid hormone and retinol in nestling bald eagles (haliaeetus leucocephalus). | polyhalogenated aromatic hydrocarbons are global contaminants that are often considered to be endocrine disruptors and include 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (p,p'-dde), polychlorinated biphenyls (pcbs), and polybrominated diphenyl ethers (pbdes). the present study examined these compounds and their hydroxylated metabolites or analogues and relationships with circulating thyroid hormones and retinols in plasma from nestling and adult bald eagles in british columbia, canada, and cal ... | 2010 | 20821573 |
| dioxin-like and perfluorinated compounds in pigs in an indian open waste dumping site: toxicokinetics and effects on hepatic cytochrome p450 and blood plasma hormones. | dioxins and related compounds (drcs) and perfluorinated compounds were measured in the livers of pigs (sus scrofa) collected from an open waste dumping site in south india. hepatic concentrations of drcs and perfluorooctanesulfonate (pfos; up to 200 ng/g wet wt) were significantly higher in male and female pigs, respectively, collected from the dumping site than in those from a reference site. results suggest that dumping sites are a source of drcs and pfos. hepatic concentrations of drcs in pig ... | 2010 | 20821605 |
| sympathetic vasoconstriction is potentiated in arteries caudal but not rostral to a spinal cord transection in rats. | sympathetic nerve-mediated contractions of mesenteric and tail arteries controlled by preganglionic neurones decentralized by a spinal cord injury (sci) are potentiated, and likely contribute to autonomic dysreflexia. however, reactivity to the α(1)-adrenoceptor agonist phenylephrine has been reported to be enhanced in vascular beds controlled by preganglionic neurones lying both rostral and caudal to an sci in vivo. here responses of isometrically-mounted median and saphenous arteries isolated ... | 2010 | 20822463 |
| measurement of thyroid hormones in donkey (equus asinus) blood and milk: validation of elisa kits and evaluation of sample collection, handling and storage. | donkey's milk is well tolerated by human infants with cow's milk allergy and is useful in the treatment of human immune-related diseases and in the prevention of atherosclerosis. thyroid hormones (th) stimulate lactation and active triiodothyronine (t3) in colostrum and milk could take paracrine action supporting lactogenesis in the mother, and play physiological roles for the suckling offspring (systemic or within the gastrointestinal tract). the aims were to measure th concentrations in donkey ... | 2010 | 20822570 |
| [microsatellite instability. a new predictive marker (?)]. | microsatellite instability (msi) is a hallmark of hereditary non-polyposis colorectal cancer (hnpcc), but also occurs in about 12%-15% of sporadic colorectal cancer (crc) where it is a consequence of an epigenetic inactivation of mlh1. high frequency msi (msi-h; i.e. at least two of five specified microsatellite markers show instability) was shown in a large meta-analysis and in recent trials to be a positive prognostic marker for overall survival in crc. msi-h or mismatch repair deficiency (mmr ... | 2010 | 20824433 |
| prevalence of goitre in isfahan, iran, fifteen years after initiation of universal salt iodization. | this cross-sectional study investigated the prevalence of goitre in isfahan, a centrally-located city in iran, 15 years after the initiation of universal salt iodization. in total, 2,523 isfahani adults (1,275 males, 1,248 females) aged > 20 years were selected by multi-stage cluster-sampling method. goitre rate, serum thyroid-stimulating hormone (tsh), thyroxine (t4), thyroid peroxidase antibody (tpoab), thyroglobulin antibody (tgab), and urinary iodine concentration (uic) were measured and com ... | 2010 | 20824978 |
| correlation between eeg abnormalities and symptoms of autism spectrum disorder (asd). | children with asd often suffer from epilepsy and paroxysmal eeg abnormality. purposes of this study are the confirmation of incidence of epileptic seizures and eeg abnormalities in children with autism using a high performance digital eeg, to examine the nature of eeg abnormalities such as locus or modality, and to determine if the development of children with asd, who have experienced developmental delay, improves when their epilepsy has been treated and maintained under control. a total of 101 ... | 2010 | 20826075 |
| a locus on chromosome 1p36 is associated with thyrotropin and thyroid function as identified by genome-wide association study. | thyroid hormones are key regulators of cellular growth, development, and metabolism, and thyroid disorders are a common cause of ill health in the community. circulating concentrations of thyrotropin (tsh), thyroxine (t4) and triiodothyronine (t3) have a strong heritable component and are thought to be under polygenic control, but the genes responsible are mostly unknown. in order to identify genetic loci associated with these metabolic phenotypes, we performed a genome-wide association study of ... | 2010 | 20826269 |
| expression of peptidylarginine deiminase type 4 in ovarian tumors. | peptidylarginine deiminase type 4 (padi4) converts arginine residues into citrulline. the current study focused on the expression of padi4 in various subtypes of ovary cancers, and this study investigated the effects of estrogen on padi4 expression in skov-3 cells that originated from ovary tumors. we utilized immunohistochemistry, real-time pcr and western blotting to analyze the expression of padi4 in the tumor tissues and in the cell line that were cultured with estrodial-17β. padi4 was detec ... | 2010 | 20827398 |
| autonomic dysreflexia-like syndrome in a t12 paraplegic during thoracic spine surgery. | a 19-year-old african american man with a t12 spinal cord lesion underwent a t4-l5 thoracolumbar spinal fusion. intraoperatively, his arterial blood pressure acutely increased from 110/60 to 260/130 mm hg without a change in heart rate. the patient did not have pheochromocytoma, carcinoid syndrome, or thyroid storm. this presentation differs from autonomic dysreflexia because the spinal cord lesion was well below t6, hypertension was elicited with somatic stimulation above the lesion, and the re ... | 2010 | 20829560 |
| programmed cell death 4 loss increases tumor cell invasion and is regulated by mir-21 in oral squamous cell carcinoma. | abstract: | 2010 | 20831814 |
| pretreatment apparent diffusion coefficient of the primary lesion correlates with local failure in head-and-neck cancer treated with chemoradiotherapy or radiotherapy. | purpose: this study was performed to evaluate whether the apparent diffusion coefficient (adc) of a primary lesion correlates with local failure in primary head-and-neck squamous cell carcinoma (hnscc) treated with chemoradiotherapy or radiotherapy. methods and materials: we retrospectively studied 38 patients with primary hnscc (12 oropharynx, 20 hypopharynx, 4 larynx, 2 oral cavity) treated with chemoradiotherapy or radiotherapy with radiation dose to gross tumor volume equal to or over 60 gy ... | 2010 | 20832179 |
| lymphocyte sub-population cell counts are associated with the metabolic syndrome and its components in the vietnam experience study. | the metabolic syndrome (mets) increases the risk of cardiovascular disease morbidity and mortality. mets is also associated with increases in the number of circulating white blood cells. lymphocyte sub-population counts have also been implicated in cardiovascular disease; this analysis will examine whether or not they are associated with mets. | 2010 | 20833394 |
| the effect of adding magnesium sulphate to epidural bupivacaine and fentanyl in elective caesarean section using combined spinal-epidural anaesthesia: a prospective double blind randomised study. | combined spinal-epidural anaesthesia is commonly used for elective caesarean section. intrathecal injection produces rapid onset with minimal doses of local anaesthetic and epidural administration can be used to prolong the block. our study examined the effects of adding magnesium sulphate to epidural bupivacaine and fentanyl in patients undergoing elective caesarean section using combined spinal-epidural anaesthesia. | 2010 | 20833531 |
| lung cancer staging essentials: the new tnm staging system and potential imaging pitfalls. | lung cancer is the leading cause of cancer-related deaths worldwide, with a dismal 5-year survival rate of 15%. the tnm (tumor-node-metastasis) classification system for lung cancer is a vital guide for determining treatment and prognosis. despite the importance of accuracy in lung cancer staging, however, correct staging remains a challenging task for many radiologists. the new 7th edition of the tnm classification system features a number of revisions, including subdivision of tumor categories ... | 2010 | 20833843 |
| serum thyroxine and age - rather than thyroid volume and serum tsh - are determinants of the thyroid radioiodine uptake in patients with nodular goiter. | radioiodine (131i) therapy is widely used for treatment of non-toxic goiters. a limitation for this treatment is a low thyroid radioiodine uptake (raiu), often encountered in these patients. | 2011 | 20834199 |
| absence of primary hypothyroidism and goiter in slc26a4 (-/-) mice fed on a low iodine diet. | background: mutations in the slc26a4 gene, coding for the anion transporter pendrin, are responsible for pendred syndrome, characterized by congenital sensorineural deafness and dyshormonogenic goiter. the physiological role of pendrin in the thyroid is still unclear and the lack of a thyroid phenotype in some patients with slc26a4 mutations and in slc26a4 (-/-) mice indicate the existence of environmental or individual modifiers able to compensate for pendrin inactivation in the thyroid. since ... | 2010 | 20834201 |
| audiologic evaluation in patients with acquired hypothyroidism. | hearing loss in hypothyroidism has been reported by many authors but its pathophysiology is unclear. | 2010 | 20835535 |
| a contemporary population-based assessment of the rate of lymph node dissection for penile carcinoma. | the adherence rate to national cancer institute (nci) recommendations regarding inguinal lymph nodes dissection (ilnd) in high grade t1 (g3t1) and t2-4 squamous cell carcinoma of the penis (sccp) is not known. we assessed ilnd rates in a north american cohort. | 2011 | 20839061 |
| cerebral cortical dynamics and the quality of motor behavior during social evaluative challenge. | to determine the influence of arousal on cerebral cortical dynamics and motor behavior, 58 channels of eeg were recorded in 13 college-age men (n=6) and women during an aiming task performed alone and in a social evaluation condition. moderate arousal, as measured by heart rate, skin conductance, and self-reported mood, was induced during the social evaluation. in accord with the yerkes-dodson hypothesis, which posits optimal performance during moderate arousal, improved performance (i.e., quali ... | 2011 | 20840197 |
| five-year incidence and progression of thyroid dysfunction in an older population. | very few studies have assessed both the incidence and progression of thyroid dysfunction in a single older population-based cohort. in this study, we aimed to assess the 5-year incidence, progression and risk factors for development of thyroid dysfunction in an older australian population. | 2010 | 20840213 |
| evidence that the impact of hearing impairment on psychosis risk is moderated by the level of complexity of the social environment. | it has been suggested that part of the increased vulnerability for psychosis in individuals with hearing impairment (hi) is the consequence of a decreased ability to form correct representations of the social world and attributions of intention of others. it was therefore hypothesized that associations between hi and psychosis risk would be sensitive to contextual variables representing higher level of social complexity, conceptualized as the population density of the social environment ('urbani ... | 2010 | 20842798 |
| treatment of graves' hyperthyroidism with thionamides-derived drugs: review. | thionamide-derived antithyroid drugs (atd) have been in use for over half a century and much is now known about their mechanism of action, pharmacokinetics and clinical pharmacology. candidates for first option atd therapy are young adults, without large goitre. the recommended initial dose for patients without big goitre and mild hyperthyroidism is 20 mg of mmi/cbz. the recommended maintenance doses are 5-10 mg of mmi/cbz. in cases of big goitre and/or severe hyperthyroidism the recommended ini ... | 2010 | 20843290 |
| [response and progression-free survival in t2 to t4 bladder tumors treated with trimodality therapy with bladder preservation]. | to evaluate the response and the free-survival progression in patients diagnosed of invasive bladder cancer who have been treated with transurethral resection, chemotherapy and radiotherapy. this multimodal treatment is compared with a not random serie of patients treated by radical cistectomy. | 2010 | 20843454 |
| hypothyroidism in patients with renal cell carcinoma: blessing or curse? | sunitinib and sorafenib are tyrosine kinase inhibitors that have important antitumor activity in metastatic renal cell carcinoma (mrcc). hypothyroidism constitutes a commonly reported side effect of both drugs, and particularly of sunitinib. the objective of this analysis was to investigate whether the occurrence of hypothyroidism during treatment with sunitinib and sorafenib affects the outcome of patients with mrcc. | 2011 | 20845482 |
| the role of thyrotropin suppression in patients with differentiated thyroid carcinoma. | thyroid carcinoma is the commonest endocrine malignancy. the majority of these are differentiated thyroid carcinomas, which have a good overall prognosis. treatment includes surgical excision, radio-iodine ablation and long-term thyrotropin suppression. the degree and length of suppression required, as well as the potential side-effect remain controversial. therefore, the aim of this study was to establish the degree of thyrotropin suppression achieved in a cohort of patients with differentiated ... | 2010 | 20845598 |
| [effect of cold property chinese medicine radix scutellariae on energy metabolism of rats]. | to observe the effect on energy metabolism of rats with cold property chinese medicine radix scutellariae. | 2010 | 20845787 |
| prospective study on the fdg-pet/ct predictive and prognostic values in patients treated with neoadjuvant chemoradiation therapy and radical surgery for locally advanced rectal cancer. | 2-[fluorine-18]fluoro-2-deoxy-d-glucose-positron emission tomography/computed tomography (fdg-pet/ct) was carried out before and after neoadjuvant chemoradiotherapy (ncrt) followed by radical surgery for locally advanced rectal cancer (larc). the aim of this study was to define its predictive and prognostic values. | 2011 | 20847032 |
| early discontinuation but not the timing of adjuvant therapy affects survival of patients with high-risk colorectal cancer: a population-based study. | adjuvant therapy results in significant improvement in survival of patients with high-risk colorectal cancer. little is known about the significance of timing and early discontinuation of adjuvant treatment in such patients. our study aims to determine the prognostic impact of timing and completion of adjuvant therapy in patients with high-risk colorectal cancer. | 2010 | 20847626 |
| clinical analysis on alteration of thyroid hormones in the serum of patients with acute ischemic stroke. | low t3 has been associated with increased short-term mortality in intensive care unit and long-term mortality in cardiovascular disease. the objective of this retrospective study is to investigate associations of thyroid hormone status with clinical severity and outcome in acute ischemic stroke, and whether there is association between the pituitary axis abnormality and the anterior/posterior circulation involvement. patients with no history of thyroid abnormality who presented first ever stroke ... | 2010 | 20847898 |
| impact and management of airway obstruction in patients with squamous cell carcinoma of the larynx. | we compared postoperative complications and oncologic results after laryngectomy of patients with laryngeal squamous cell carcinoma (scc), with and without airway obstruction. | 2011 | 20848422 |
| long-term results of 28 esthesioneuroblastomas managed over 35 years. | the purpose of our study was to assess the long-term results in the management of patients with esthesioneuroblastoma. | 2011 | 20848423 |
| [protective effect of "neiguan" (pc 6)-electroacupuncture preconditioning on the myocardium in myocardial ischemia/reperfusion rats]. | to investigate the effects of "neiguan" (pc 6)-electroacupunture (ea) preconditioning on the myocardium and its mast cells in myocardial ischemia/reperfusion (mi/r) rats. | 2010 | 20848892 |
| uncalibrated arterial pulse cardiac output measurements in patients with moderately abnormal left ventricular function. | the aim of the study was to evaluate the accuracy and precision of the vigileo/flotrac system (edwards lifesciences, irvine, ca) when compared with the intermittent cardiac output and continuous cardiac output measurements obtained from pulmonary arterial catheters in patients with moderately abnormal left ventricular function undergoing elective coronary artery bypass graft surgery. | 2011 | 20850989 |
| [thyroid dysfunction in hospital worker population]. | the prevalence of thyroid dysfunction (td) and thyroid autoimmunity (ta) in hospital employees in our country is unknown. | 2010 | 20851391 |
| impact of intracranial extension on survival in stage iv nasopharyngeal carcinoma: identification of a subset of patients with better prognosis. | t-stage is an imperfect prognostic indicator for patients with nasopharyngeal carcinoma. we evaluated the effect of extent of intracranial involvement on survival after conventional radiotherapy in patients with stage t4 nasopharyngeal carcinoma. | 2011 | 20852300 |
| determinants of eukaryal cell killing by the bacterial ribotoxin prrc. | trna damage inflicted by the escherichia coli anticodon nuclease prrc (ecoprrc) underlies an antiviral response to phage t4 infection. prrc homologs are present in many bacterial proteomes, though their biological activities are uncharted. prrcs consist of two domains: an n-terminal ntpase module related to the abc family and a distinctive c-terminal ribonuclease module. in this article, we report that the expression of ecoprrc in budding yeast is fungicidal, signifying that prrc is toxic in a e ... | 2011 | 20855293 |
| relationship between thyroid stimulating hormone and thyroid stimulating immunoglobulin in graves' hyperthyroidism. | in graves' hyperthyroidism, suppression of serum tsh after restoration of normal serum t4 and t3 with treatment has been attributed to binding of tsh-receptor antibodies to tsh receptors in the pituitary. accordingly, the relationship between tsh and serum thyroid stimulating immunoglobulin (tsi) was examined during follow-up of patients with graves' hyperthyroidism. | 2011 | 20855936 |
| primary spinal cord melanoma. | primary central nervous system (cns) melanoma is a rare condition that accounts for only 1% of all melanomas. a 34-year-old korean female presented with a two-month history of progressive weakness in both legs. spinal magnetic resonance image (mri) revealed a spinal cord tumor at the level of t4, which was hyperintense on t1-weighted imaging and hypointense on t2-weighted imaging. the intradural and extramedullary tumor was completely resected and diagnosed as melanoma. there were no metastatic ... | 2010 | 20856666 |
| survival and quality of life of patients with oral and oropharyngeal cancer at 1-year follow-up of tumor resection. | this study aimed to assess the survival and life quality evolution of patients subjected to surgical excision of oral and oropharyngeal squamous cell carcinoma. | 2010 | 20857008 |
| [spinal anesthesia in a patient with smon disease]. | we report a patient with subacute myelo-optico-neuropathy (smon) in whom spinal anesthesia was employed to treat fracture of the femur neck. an 87-year-old woman was diagnosed as having smon at the age of 45. the patient was admitted to our hospital with fracture of the femur neck. aspiration pneumonia was also suspected with shadow in the right lung on the chest x-p the percutaneous oxygen saturation (spo2) with room air was 77%. spinal anesthesia with 5 mg of 0.5% hyperbaric bupivacaine and 20 ... | 2010 | 20857682 |
| the hammersmith hospital hematopathology case of the month: paraspinal b lymphoblastic lymphoma – problems in diagnosis and initial indolent behavior. | we describe a young man who presented with neurological signs and symptoms, and with a paraspinal soft tissue mass involving the vertebral body at t4. the patient was treated with dexamethasone prior to neurosurgical decompression and debulking. biopsy showed features of a small b-cell lymphoma possibly of follicle center cell origin. the patient achieved complete remission with radiotherapy. however, he experienced relapse 10 months later with a soft tissue mass close to and involving the poste ... | 2010 | 20858095 |
| isolation and characterization of acanthamoeba spp. from air-conditioners in kuala lumpur, malaysia. | during a study on the quality of the indoor environment, acanthamoeba spp. were detected in 20 out of 87 dust samples collected from air-conditioners installed in a four-story campus building located in kuala lumpur, malaysia. twenty-one cloned acanthamoeba isolates designated as imu1 to imu21 were established from the positive primary cultures. five species were identified from the 16 isolates according to the morphological criteria of pussard and pons; i.e. a. castellanii, a. culbertsoni, a. g ... | 2011 | 20858455 |
| overstaging of cartilage invasion by multidetector ct scan for laryngeal cancer and its potential effect on the use of organ preservation with chemoradiation. | the two currently acceptable treatment options for locally advanced laryngeal cancer are total laryngectomy and organ preservation using chemoradiation. to facilitate therapeutic decision making, the accurate pre-treatment evaluation of cartilage invasion is of paramount importance. the purpose of this study was to evaluate the positive predictive value (ppv) and negative predictive value (npv) of detecting neoplastic cartilage invasion in laryngeal cancer patients using fast-speed multidetector ... | 2011 | 20858661 |
| [nazi action t4 euthanasia programme: historical research, individual life stories and the culture of remembrance]. | the psychiatric patients killed under the disguise of euthanasia during world war ii belong to the group of victims which are often forgotten in public remembrance. for german and austrian psychiatry it is important to include them into the memory of the discipline as well as into european remembrance of the victims of nazi annihilation policy. the patient files of the victims enable us to reconstruct the criterion of economic usefulness for deciding about life or death. but above all the files ... | 2010 | 20859734 |
| variable suppression of serum thyroxine in female mice of different inbred strains by triiodothyronine administered in drinking water. | recombinant-inbred mouse strains differ in their susceptibility to graves'-like hyperthyroidism induced by immunization with adenovirus expressing the human thyrotropin (tsh) receptor. because one genetic component contributing to this susceptibility is altered thyroid sensitivity to tsh receptor agonist stimulation, we wished to quantify thyroid responsiveness to tsh. for such studies, it is necessary to suppress endogenous tsh by administering l-3,5,3′-triiodothyronine (l-t3), with the subsequ ... | 2010 | 20860425 |
| quantification of cyclobutane pyrimidine dimers induced by uvb radiation in conidia of the fungi aspergillus fumigatus, aspergillus nidulans, metarhizium acridum and metarhizium robertsii. | conidia are responsible for reproduction, dispersal, environmental persistence and host infection of many fungal species. one of the main environmental factors that can kill and/or damage conidia is solar uv radiation. cyclobutane pyrimidine dimers (cpd) are the major dna photoproducts induced by uvb. we examined the conidial germination kinetics and the occurrence of cpd in dna of conidia exposed to different doses of uvb radiation. conidia of aspergillus fumigatus, aspergillus nidulans and met ... | 2010 | 20860693 |
| high-temperature optical spectral weight and fermi-liquid renormalization in bi-based cuprate superconductors. | the optical conductivity σ(ω) and the spectral weight w(t) of two superconducting cuprates at optimum doping, bi2sr2-xlaxcuo6 and bi2sr2cacu2o8, have been first measured up to 500 k. above 300 k, w(t) deviates from the usual t2 behavior in both compounds, even though σ(ω→0) remains larger than the ioffe-regel limit. the deviation is surprisingly well described by the t4 term of the sommerfeld expansion, but its coefficients are enhanced by strong correlation, as shown by the good agreement with ... | 2010 | 20868070 |
| structures at risk from pedicle screws in the proximal thoracic spine: computed tomography evaluation. | pedicle screw placement in the proximal thoracic spine may result in unwanted bicortical breach. an understanding of the potential structures at risk is paramount to safe screw placement. | 2010 | 20869005 |
| the role of choline positron emission tomography/computed tomography in the management of patients with prostate-specific antigen progression after radical treatment of prostate cancer. | choline positron emission tomography (pet)/computed tomography (ct) is a currently used diagnostic tool in restaging prostate cancer (pca) patients with increasing prostate-specific antigen (psa) after either radical prostatectomy (rp) or external-beam radiation therapy (ebrt). however, no final recommendations have been made on the use of this modality for patient management. | 2010 | 20869161 |
| biochemical recurrence following robot-assisted radical prostatectomy: analysis of 1384 patients with a median 5-year follow-up. | there is a paucity of data on long-term oncologic outcomes for patients undergoing robot-assisted radical prostatectomy (rarp) for prostate cancer (pca). | 2010 | 20869162 |
| effects of nonylphenol on early embryonic development, pigmentation and 3,5,3'-triiodothyronine-induced metamorphosis in bombina orientalis (amphibia: anura). | nonylphenol (np) is an estrogenic endocrine disruptor in many aquatic species. in an effort to highlight the developmental toxicity of np in amphibians, we examined the effects of np on the embryonic survival, tadpole growth, melanophore development and metamorphosis of a native korean amphibian species, bombina orientalis (anura). when treated to fertilized eggs, 1 μm np significantly decreased embryonic survival at 48 h post fertilization (p.f.), suggesting that 1 μm np can exert systemic toxi ... | 2010 | 20870264 |
| a longitudinal study of the effects of a hope intervention on levels of hope and psychological distress in a community-based sample of oncology patients. | purpose of research: to determine the effect of the hope intervention (hope-in) on levels of hope and psychological distress immediately (t2), 3 (t3), and 12 (t4) months following the intervention; determine the effects of the hope-in on changes in patients' level of hope after controlling for baseline levels of psychological distress; and evaluate patients' level of satisfaction with the hope-in. methods and sample: this single group, longitudinal study recruited a community-based sample which ... | 2010 | 20870459 |
| tumor budding as a strong prognostic indicator in invasive ampullary adenocarcinomas. | prognostication of invasive ampullary adenocarcinomas (aacs) and their stratification into appropriate management categories have been highly challenging owing to a lack of well-established predictive parameters. in colorectal cancers, recent studies have shown that tumor budding confers a worse prognosis and correlates significantly with nodal metastasis and recurrence; however, this has not been evaluated in aac.to investigate the prevalence, significance, and clinical correlations of tumor bu ... | 2010 | 20871215 |