Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| the number of lymph nodes examined debate in colon cancer: how much is enough? | much debate exists over the significance of the number of lymph nodes (ln) examined after colon resection. | 2010 | 20638686 |
| alterations of postawakening cortisol parameters during a prolonged stress period: results of a prospective controlled study. | though postawakening cortisol is considered to be altered under chronic stress prospective studies proving this assumption is missing, so far. furthermore, there is some uncertainty which aspects of postawakening cortisol alterations are strongest related to stress. the present study thus analyzed the cortisol concentration at awakening itself (0 min), the cortisol awakening response (car; i.e. the increase within 30 min after awakening), the area under the curve of the first hour after awakenin ... | 2010 | 20638949 |
| severity of acute pain after breast surgery is associated with the likelihood of subsequently developing persistent pain. | persistent postsurgical pain (ppsp) after surgery for breast cancer has a prevalence of 20% to 52%. neuroplastic changes may play a role in the aetiology of this pain. the principal objective of this study was to examine the relationship between acute pain after surgery for breast cancer and the likelihood of subsequently developing ppsp. | 2010 | 20639740 |
| subarachnoid hemorrhage following posterior spinal artery aneurysm. a case report and review of the literature. | isolated posterior spinal artery aneurysms are rare vascular lesions. we describe the case of a 43-year-old man presenting with spinal subarachnoid hemorrhage after a minor trauma who was found to have a dissecting aneurysm of a posterior spinal artery originating from the right t4 level. endovascular treatment was not contemplated because of the small size of the feeding artery, whereas surgical resection was deemed more appropriate because of the posterolateral perimedullary location that was ... | 2010 | 20642894 |
| thyroid storm after pediatric levothyroxine ingestion. | a 2-year-old girl was found with an empty bottle of levothyroxine and blue coloring around her mouth. forty tablets of 150-microg levothyroxine tablets were missing. her 6-hour postingestion total thyroxine (t4) level was 68.1 microg/dl (normal range: 5-12 microg/dl), and her total triiodothyronine (t3) level was 472 ng/dl (normal range: 40-130 ng/dl). serum levels of thyrotropin, t3, and t4 were then checked on days 3, 5, 7, and 10. on postingestion day 5, the child presented for follow-up with ... | 2010 | 20643722 |
| unrestricted migration favours virulent pathogens in experimental metapopulations: evolutionary genetics of a rapacious life history. | understanding pathogen infectivity and virulence requires combining insights from epidemiology, ecology, evolution and genetics. although theoretical work in these fields has identified population structure as important for pathogen life-history evolution, experimental tests are scarce. here, we explore the impact of population structure on life-history evolution in phage t4, a viral pathogen of escherichia coli. the host-pathogen system is propagated as a metapopulation in which migration betwe ... | 2010 | 20643740 |
| prognostic information from sentinel lymph node biopsy in patients with thick melanoma. | sentinel lymph node (sln) biopsy provides valuable prognostic information for patients with thick (t4) melanoma. | 2010 | 20644123 |
| isolated extradural rosai-dorfman disease of the thoracic spine: a rare cause of spinal cord compression: case report. | rosai-dorfman disease is a rare benign histiocytic disease of unknown origin that arises predominantly in lymph nodes with generalized fever and malaise but can affect a variety of organs. we describe a case of isolated rosai-dorfman disease causing thoracic cord compression. | 2010 | 20644383 |
| the rational use of pituitary stimulation tests. | diseases of the pituitary gland can lead to the dysfunction of individual hormonal axes and to the corresponding clinical manifestations. the diagnostic assessment of pituitary function has not yet been standardized. | 2010 | 20644702 |
| [multiple-injection thoracic paravertebral block for reconstructive breast surgery]. | to describe the use of multiple-injection thoracic paravertebral blockade, with intravenous sedation, for anesthesia during reconstructive breast surgery. | 2010 | 20645487 |
| [hormone replacement therapy after total thyroidectomy. can the combined treatment be considered effective to get metabolic adequacy? preliminary results]. | even if t4 is standard treatment for hypothyroidism after thyroidectomy, a treatment with t4 plus t3 has been proposed as an alternative reproducing carefully the physiology of the thyroid. we performed an observational study about the effects of the combined replacement therapy with t4 and t3 in patients who underwent total thyroidectomy. | 2010 | 20646377 |
| effects of housing and short-term transportation on hormone and lymphocyte receptor concentrations in beef cattle. | the experiment was designed to evaluate the effects of housing system and short-term transportation on the pituitary and adrenal response and on blood progesterone concentrations of beef cattle. since the use of steroid hormones in farm animals has been banned in the eu (council directive 96/22/ec), it seems important to study the possible modifications in serum progesterone concentrations induced by stress in cattle. thirty-two, 6 months old male piedmontese beef cattle (16 reared in a littered ... | 2011 | 20646728 |
| candidate dosimetric predictors of long-term swallowing dysfunction after oropharyngeal intensity-modulated radiotherapy. | to investigate long-term swallowing function in oropharyngeal cancer patients treated with intensity-modulated radiotherapy (imrt), and to identify novel dose-limiting criteria predictive for dysphagia. | 2010 | 20646872 |
| bile compound-induced dna damage and repair in bacteriophage t4. | two bile acids (cholic acid and chenodeoxycholic acid) and two bile salts (sodium cholate and sodium deoxycholate) were shown to inactivate bacteriophage t4. the inactivation was largely reversed when the phage was allowed to undergo recombinational repair, indicating that bile compounds cause dna damage. | 1987 | 20647079 |
| influence of preoperative chemoradiotherapy on the number of lymph nodes retrieved in rectal cancer. | to evaluate the relation of preoperative chemoradiotherapy to the number of lymph nodes retrieved in curative intent surgery for rectal cancer. | 2010 | 20647928 |
| acceleromyographic monitoring of neuromuscular block over the orbicularis oris muscle in anesthetized patients receiving vecuronium. | to evaluate the level of neuromuscular block acceleromyographically over the orbicularis oris muscle. | 2010 | 20650376 |
| brownian dynamics simulations of electrophoretic dna separations in a sparse ordered post array. | we use brownian dynamics simulations to analyze the electrophoretic separation of lambda-dna (48.5kbp) and t4-dna (169kbp) in a hexagonal array of 1microm diameter posts with a 3microm center-to-center distance. the simulation method takes advantage of an efficient interpolation algorithm for the non-uniform electric field to reach an ensemble size (100 molecules) and simulation length scale (1mm) that produces meaningful results for the average electrophoretic mobility and effective diffusion ( ... | 2010 | 20650462 |
| changes in autonomic regulation and ventricular repolarization induced by subclinical hyperthyroidism. | the aim of the present study was to evaluate the effect of subclinical hyperthyroidism (sht) on cardiovascular autonomic function and ventricular repolarization. | 2010 | 20650598 |
| stress-induced pseudocyst formation--a newly identified mechanism of protection against organic solvents in acanthamoebae of the t4 genotype. | differentiation into highly resistant double-walled cysts is a major mechanism allowing amphizoic acanthamoebae to survive under long-lasting, unfavourable environmental conditions. we found that relatively low concentrations of methanol, acetone or dmso stimulate promptacanthamoebadifferentiation into a rounded cyst-like stage with a single envelope. to address whether this rapid response differs from the encystment, time-dependent changes in cell surface characteristics and cyst-specific gene ... | 2011 | 20650683 |
| possible roles of phospholipase a(2) in the biological activities of acanthamoeba castellanii (t4 genotype). | using phospholipases a(2)-specific spectrophotometric assays, it was shown thata. castellaniilysates and their conditioned medium exhibit phospholipase activities. the extracellular levels of pla(2)detected were significantly reduced compared with the cell-associated enzyme (p<0.05). sphinganine, a pla(2)inhibitor showed robust amoebistatic properties but had no effect on the viability ofa. castellanii. the potency of sphinganine was demonstrated effectively towards purified pla(2)derived from p ... | 2011 | 20650684 |
| [accuracy of perioperative cardiac preload monitoring by global end-diastolic volume and intrathoracic blood volume in orthotopic liver transplantation]. | to investigate the clinical value of global end-diastolic volume (gedv) and intrathoracic blood volume (itbv) in perioperative monitoring of the cardiac preload in patients undergoing orthotopic liver transplantations (olt). | 2010 | 20650770 |
| acid-base alterations during laparoscopic abdominal surgery: a comparison with laparotomy. | carbon dioxide insufflation during laparoscopic surgery results in an acid-base imbalance. the purpose of this study was to investigate the effect of pneumoperitoneum on the acid-base status using stewart's approach. | 2010 | 20650921 |
| [lung cancer from the perspective of internal medicine and surgery]. | in previous years numerous advances in diagnostics, staging and therapy of lung cancer have been achieved. nevertheless, it remains the most frequent cause of death from cancerous diseases. early diagnosis and exact staging enable multimodal therapy regimens adjusted to age and comorbidities, which result in complete remission in a few and in prolonged survival and good quality of life in most patients. curative surgery is possible in stage i non-small cell lung cancer (nsclc) and results in a 5 ... | 2010 | 20652215 |
| dermokine as a novel biomarker for early-stage colorectal cancer. | colorectal cancer is a common disease that is usually detected at an advanced stage, because early-stage cancer is mostly asymptomatic and appropriate serologic biomarkers have not been established. we have previously identified dermokine (dk) as a peptide secreted by keratinocytes and we found that dk-β/γ was expressed in colorectal tumors. therefore, we focused on dk-β/γ as a new candidate diagnostic serum marker for early colorectal cancer. | 2010 | 20652332 |
| t4 colorectal cancer: is laparoscopic resection contraindicated? | t4 colorectal cancer remains a contraindication for laparoscopy. it is argued that the risk of incomplete resection could be higher than in open surgery. furthermore, difficulty in dissection could lead to a very high rate of conversion. there is little information on this. the study aimed at assessing feasibility and operative and oncologic results of laparoscopic resection for t4 colorectal cancer. | 2011 | 20653697 |
| [effect of niobium nitride on the bonding strength of titanium porcelain by magnetron sputtering]. | to investigate the effect of magnetron sputtered niobium nitride (nbn) on the bonding strength of commercially pure cast titanium (ti) and low-fusing porcelain (ti/vita titankeramik system). | 2010 | 20654251 |
| effect of thyroid hormones onflavin-containing monooxygenase activity in co-cultured adult rat hepatocytes. | the regulation of flavin-containing monooxygenase (fmo) by thyroid hormones was examined under well defined in vitro conditions using adult male rat hepatocytes co-cultured with rat liver epithelial cells of primitive biliary origin. serum free medium was used to avoid interferences from foetal bovine serum. the effect of thyroxine (t4) and its major metabolite l-triiodothyronine (t3) on fmo activity was estimated spectrophotometrically by measuring the rate of methimazole oxygenation. the highe ... | 1998 | 20654415 |
| [evaluation of thyroid function during pregnancy: first-trimester reference intervals for thyroid-stimulating hormone and free thyroxine]. | the physiological changes that occur during pregnancy affect the physiology of the thyroid gland. consequently, interpretation of thyroid function markers during pregnancy requires trimester-specific reference intervals. the aims of our study were to: 1) establish first-trimester reference intervals for biochemical markers of thyroid function [thyroid-stimulating hormone (tsh) and free thyroxine (t4)] and 2) to establish the prevalence of autoimmune thyroid disease in pregnant women resident in ... | 2010 | 20655816 |
| endocrine controls of primary adult human stem cell biology: thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro. | here we demonstrate that physiological concentrations of the thyroid hormones t3 and t4 enhance the keratin 15 promoter activity and expression in epithelial stem cells of adult human scalp hair follicles in situ and in vitro. additionally, t3 and t4 stimulate expression of the immuno-inhibitory surface molecule cd200. subsequently, t3 and t4 induce apoptosis and differentiation and inhibit clonal growth of these progenitor cells in vitro. these data suggest that human hair follicle bulge-derive ... | 2010 | 20656376 |
| preoperative chemoradiation for rectal cancer using capecitabine and celecoxib correlated with posttreatment assessment of thymidylate synthase and thymidine phosphorylase expression. | purpose: thymidylate synthase (ts) and thymidine phosphorylase (tp) expression have been shown to be predictors of response to therapy. the toxicity, efficacy, surgical morbidity, and immunohistochemical ts and tp expression were assessed in surgical resection specimens after preoperative chemoradiation. methods and materials: twenty patients with clinical stage i to iii rectal adenocarcinoma received preoperative chemoradiation and underwent surgical resection 6 weeks later. results: posttreatm ... | 2010 | 20656421 |
| accuracy of preoperative ct for local staging in colorectal carcinomas. | this study aimed to determine the accuracy of computed tomography (ct) in the evaluation of local tumour invasion and regional lymphadenopathy in colorectal carcinomas. | 2010 | 20658106 |
| linear and non-linear eeg analysis of adolescents with attention-deficit/hyperactivity disorder during a cognitive task. | we aimed to investigate whether electroencephalograph (eeg) dynamics differ in adolescents with attention-deficit/hyperactivity disorder (adhd) compared with healthy subjects during the performance of a cognitive task. | 2010 | 20659814 |
| effects of unfractioned heparin and low-molecular-weight heparin on osteoprotegerin and rankl plasma levels in haemodialysis patients. | this randomized crossover study investigated the effects of unfractioned heparin (ufh) and low-molecular-weight heparin (lmwh) on intra- and post-dialytic blood levels of osteoprotegerin (opg), receptor activator of nuclear factor kappa b ligand (rankl) and inflammatory cytokines. | 2011 | 20659908 |
| feed utilisation of ethiopian highland lambs on a basal diet of eleucine coracana straw and supplemented with variously sourced protein mixed with wheat bran. | the study investigated the effect of supplementation of a basal diet of eleucine coracana (finger millet) straw with different protein sources mixed with wheat bran on feed utilisation in ethiopian highland lambs. twenty yearling intact male lambs (14.9 ± 0.30 kg; mean ± sd) were used in a randomised complete block design. dietary treatments included a basal diet of e. coracana straw ad libitum (t1); basal diet supplemented with a mixture of 222 g noug seed (guizotia abyssinica) cake (nsc) and 7 ... | 2011 | 20661642 |
| construction of robust bio-nanotubes using the controlled self-assembly of component proteins of bacteriophage t4. | 2010 | 20661999 | |
| low-level laser therapy in chronic autoimmune thyroiditis: a pilot study. | chronic autoimmune thyroiditis (cat) remains the most common cause of acquired hypothyroidism. there is currently no therapy that is capable of regenerating cat-damaged thyroid tissue. the objective of this study was to gauge the value of applying low-level laser therapy (lllt) in cat patients based on both ultrasound studies (uss) and evaluations of thyroid function and thyroid autoantibodies. | 2010 | 20662037 |
| the evaluation of the adrenal and thyroid axes and glucose metabolism after burn injury in children. | burn injury is an important trauma and can cause many hormonal and metabolic changes in the human body. in contrast to the situation with adults, there are inadequate number of studies on children with this condition. our aim in this study was to determine the changes in the adrenal, thyroid axes and glucose metabolism in the acute and subacute period and relation to the percent total body surface area (tbsa) burned in children with major burn injury. | 2010 | 20662347 |
| genomic analysis of oceanic cyanobacterial myoviruses compared with t4-like myoviruses from diverse hosts and environments. | t4-like myoviruses are ubiquitous, and their genes are among the most abundant documented in ocean systems. here we compare 26 t4-like genomes, including 10 from non-cyanobacterial myoviruses, and 16 from marine cyanobacterial myoviruses (cyanophages) isolated on diverse prochlorococcus or synechococcus hosts. a core genome of 38 virion construction and dna replication genes was observed in all 26 genomes, with 32 and 25 additional genes shared among the non-cyanophage and cyanophage subsets, re ... | 2010 | 20662890 |
| [construction of eukaryote expression vector carrying human pulmonary surfactant-associated protein c and its expression in vitro]. | to clone human pulmonary surfactant-associated protein c (sp-c) and construct an eukaryote expression vector pcdna3.1(+)/sp-c, and then to examine the sp-c expression in vitro, which may provide a reliable way of massive production of sp-c. | 2010 | 20663299 |
| functional paragangliomas of the urinary bladder: a report of 9 cases. | functional paraganglioma of the urinary bladder (fpub) is a rare tumor. misdiagnosis of fpub before operation can lead to serious intraoperative consequences. in this article, we reported our experience in preoperative diagnosis and surgical treatment of fpub. | 2010 | 20663319 |
| postoperative radiotherapy improved survival of poor prognostic squamous cell carcinoma esophagus. | the purpose of this study was identify prognostic factors and to investigate the association between postoperative radiotherapy and overall survival of thoracic esophageal squamous cell carcinoma patients. | 2010 | 20667325 |
| influence of topical dexamethasone applications on insulin, glucose, thyroid hormone and cortisol levels in dogs. | the influence of two topical dexamethasone applications (dermal and ototopical) on plasma insulin, glucose, thyroid hormone and cortisol levels was investigated in beagle dogs. both treatments significantly decreased basal cortisol values, associated with exaggerated rise in insulin (∼50%), together with unchanged serum glucose levels. dermal dexamethasone quickly decreased plasma thyroxin (t(4)) levels; whereas dexamethasone in ear drops gradually inhibited time-dependently t(4) release (18-50% ... | 2011 | 20667567 |
| igf-1 splice variant and igf-1 peptide expression patterns in young and old human skeletal muscle prior to and following sequential exercise bouts. | genes and proteins involved in insulin-like growth factor (igf)-1 signaling are thought to be differentially expressed in older versus younger mammalian skeletal muscle following acute exercise. the purpose of this study was to examine how multiple bouts of conventional resistance training meant to elicit hypertrophy affect the mrna expression of igf-1ea and igf-1ec (mgf) as well as the expression of total igf-1 peptides in human skeletal muscle. ten younger (18-25 years) and 10 older (60-75 yea ... | 2010 | 20668872 |
| [erythrocyte protective effects of ginaton in patients undergoing hypothermic cardiopulmonary bypass]. | to investigate the erythrocyte protective effects of ginaton, a ginkgo biloba extract, in patients undergoing hypothermic cardiopulmonary bypass (cpb). | 2010 | 20669670 |
| further decrease in glycated hemoglobin following ingestion of a lobag30 diet for 10 weeks compared to 5 weeks in people with untreated type 2 diabetes. | abstract: | 2010 | 20670414 |
| [acute renal failure in the course of hashimoto's thyroiditis]. | hashimoto's thyroiditis is the commonest form of autoimmune thyroiditis in the world. it occurs most frequently in women (female/male ratio, 6:1) in the age group between 30 and 60 years. here we report the case of a 38-year-old caucasian man who presented with a few days' history of upper limb paresthesias, widespread joint and muscle pain, and headaches. laboratory findings showed increased cpk, myoglobin and plasma creatinine levels with acute renal failure. low free t3 and t4 values associat ... | 2010 | 20672239 |
| validation of the 2009 tnm version in a large multi-institutional cohort of patients treated for renal cell carcinoma: are further improvements needed? | a new edition of the tnm was recently released that includes modifications for the staging system of kidney cancers. specifically, t2 cancers were subclassified into t2a and t2b (< or =10 cm vs >10 cm), tumors with renal vein involvement or perinephric fat involvement were classified as t3a cancers, and those with adrenal involvement were classified as t4 cancers. | 2010 | 20674150 |
| [evaluation of immediate breast reconstruction and radiotherapy: factors associated with complications]. | to determine prospectively the factors associated with reconstruction failure (i.e. requiring expander removal) and capsular contracture in patients undergoing mastectomy and immediate two-stage breast reconstruction with a tissue expander and implant, and radiotherapy for breast cancer. this is a multi-institutional prospective nonrandomized trial. | 2010 | 20674442 |
| neuropeptide coding of sympathetic preganglionic neurons; focus on adrenally projecting populations. | chemical coding of sympathetic preganglionic neurons (spn) suggests that the chemical content of subpopulations of spn can define their function. since neuropeptides, once synthesized are transported to the axon terminal, most demonstrated chemical coding has been identified using immunoreactive terminals at the target organ. here, we use a different approach to identify and quantify the subpopulations of spn that contain the mrna for pituitary adenylate cyclase activating polypeptide (pacap) or ... | 2010 | 20674686 |
| ischemia-reperfusion histopathology alterations of the rabbit intestinal wall with and without exclusion of the collateral mesenteric circulation supply. | to evaluate the histopathology alterations of the intestinal mucosa of rabbits submitted to different times of mesenteric artery ischemia and reperfusion with and without celiac artery collateral circulation supply. | 2010 | 20676487 |
| predictors of postoperative survival in patients with locally advanced non-small cell lung carcinoma. | a surgical resection for locally advanced non-small cell lung carcinoma (nsclc) remains controversial. this study analyzed the clinicopathological profile and surgical outcome of patients with locally advanced nsclc to identify the predictors of survival. | 2010 | 20676855 |
| surgical therapeutic strategy for non-small cell lung cancer with mediastinal lymph node metastasis (n2). | approximately 30% of patients who are diagnosed with non-small cell lung cancer (nsclc) are classified as n2 on the basis of metastasis to the mediastinal lymph nodes. the effectiveness of surgery for these patients remains controversial. although surgeries in recent years are proved to be effective to some extent, yet due to many reasons, 5-year survival rate after surgery varies greatly from patient to patient. thus it is necessary to select patients who have a high probability of being be cur ... | 2010 | 20677562 |
| pulpal blood flow changes due to rapid maxillary expansion. | to determine the pulpal blood flow (pbf) changes in anchorage teeth associated with the high forces of a rapid maxillary expansion (rme) appliance. | 2010 | 20677966 |
| mice deficient in mct8 reveal a mechanism regulating thyroid hormone secretion. | the mechanism of thyroid hormone (th) secretion from the thyroid gland into blood is unknown. humans and mice deficient in monocarboxylate transporter 8 (mct8) have low serum thyroxine (t4) levels that cannot be fully explained by increased deiodination. here, we have shown that mct8 is localized at the basolateral membrane of thyrocytes and that the serum th concentration is reduced in mct8-ko mice early after being taken off a treatment that almost completely depleted the thyroid gland of th. ... | 2010 | 20679730 |
| the value of clinical prognostic factors for survival in patients with invasive urinary bladder cancer. | the aim of the study was to evaluate the value of clinical prognostic factors for survival of patients with invasive urinary bladder cancer treated with radical cystectomy, chemotherapy, and radiotherapy. | 2010 | 20679745 |
| largest molecular clusters in the supertetrahedral tn series. | supertetrahedral tn clusters are exact fragments of cubic zns-type lattice and are often formed in situ as building units for the construction of 3-d open-framework chalcogenide materials. small tn clusters can also be synthesized in discrete forms, allowing them to exist as soluble species in solution. in addition to their tunable electronic and optical properties, these soluble clusters can be used as precursors for the synthesis of porous semiconducting and optical materials. however, the syn ... | 2010 | 20681716 |
| prolonged jaundice in newborns is associated with low antioxidant capacity in breast milk. | in breastfeeding newborns who are otherwise healthy, the mechanism of prolonged jaundice remains unclear. the aim of this study was to investigate relations between prolonged jaundice and oxidative parameters in breast milk. full-term, otherwise healthy newborns with jaundice lasting more than 2 weeks were enrolled prospectively in the study. as a control group, newborns in the same age group but without prolonged jaundice were selected. all newborns in the study were exclusively breastfed. in t ... | 2010 | 20681927 |
| reparation of chlorpyrifos-induced impairment by thyroxine and vitamin c in fish. | the organophosphate pesticide chlorpyrifos significantly decreased the specific activities of catalase (cat) and lactate dehydrogenase (ldh) in brain, liver, gill and skeletal muscle of the freshwater catfish, heteropneustes fossilis. it may be due to binding of the pesticide or its metabolite(s) with the enzyme molecules or affecting the synthesis and/or degradation of the enzymes. rna and protein content also declined significantly in different tissues of the fish in response to chlorpyrifos, ... | 2010 | 20684993 |
| laser-evoked potentials habituation in fibromyalgia. | abnormalities of central pain processing play an important role in the pathophysiology of fibromyalgia (fm). the aims of the present study were to: 1) evaluate habituation of laser-evoked potentials (lep) to repeated painful stimulation of 1 tender and 2 nontender points; and 2) determine correlations between lep abnormalities and major clinical features of fm. fourteen consecutive fm outpatients and 13 normal controls were included. lep were recorded from scalp designations fz, cz, pz, t3, and ... | 2011 | 20685171 |
| molecular characterization and gene expression of thyrotropin receptor (tshr) and a truncated tshr-like in senegalese sole. | thyroid hormones (ths) play a key role in larval development, growth and metamorphosis in flatfish. their synthesis is tightly regulated by the hypothalamic-pituitary-thyroid axis. thyroid-stimulating hormone receptor (tshr) is a key protein in the control of thyroid function stimulating th synthesis after binding its ligand, the thyrotropin. in teleost fish, numerous reports have associated the tshr with gametogenesis. however, little information about its role during larval development is avai ... | 2010 | 20685365 |
| a specific docking site for dna polymerase {alpha}-primase on the sv40 helicase is required for viral primosome activity, but helicase activity is dispensable. | replication of simian virus 40 (sv40) dna, a model for eukaryotic chromosomal replication, can be reconstituted in vitro using the viral helicase (large tumor antigen, or tag) and purified human proteins. tag interacts physically with two cellular proteins, replication protein a and dna polymerase α-primase (pol-prim), constituting the viral primosome. like the well characterized primosomes of phages t7 and t4, this trio of proteins coordinates parental dna unwinding with primer synthesis to ini ... | 2010 | 20685648 |
| critical analysis of mucin and signet ring cell as prognostic factors in an asian population of 2,764 sporadic colorectal cancers. | conflicting data on the clinicopathological characteristics as well as prognosis and survival of signet ring cell (src) and mucinous adenocarcinomas (ma) of the colorectum persist. | 2010 | 20686777 |
| effects of breast cancer surgery and surgical side effects on body image over time. | we examined the impact of surgical treatments (breast-conserving surgery [bcs], mastectomy alone, mastectomy with reconstruction) and surgical side-effects severity on early stage (0-iia) breast cancer patients' body image over time. we interviewed patients at 4-6 weeks (t1), six (t2), 12 (t3), and 24 months (t4) following definitive surgical treatment. we examined longitudinal relationships among body image problems, surgery type, and surgical side-effects severity using the generalized estimat ... | 2011 | 20686836 |
| overall and cause-specific survival for patients undergoing lobectomy, near-total, or total thyroidectomy for differentiated thyroid cancer. | the extent of surgery for well-differentiated thyroid cancer remains controversial. the purpose of this study was to evaluate the type of resection, age, t classification, nodal status, tumor size, and year of diagnosis for overall survival (os) and cause-specific survival (css) using a large database. | 2011 | 20687168 |
| neuroendocrine dysfunction in patients recovering from subarachnoid hemorrhage. | subarachnoid hemorrhage (sah) is a recently identified risk factor for hypopituitarism, particularly growth hormone (gh) and corticotrophins deficiencies. the aim of our study was to identify possible predictor(s) for neuroendocrine dysfunction in sah survivors. | 2010 | 20688621 |
| combined therapy with l-thyroxine and l-triiodothyronine compared to l-thyroxine alone in the treatment of primary hypothyroidism. | the objective of this study was to compare various parameters in patients with hypothyroidism receiving either monotherapy with l-thyroxine (l-t4) or combination therapy with l-t4 and l-triiodothyronine (l-t3). | 2010 | 20688622 |
| relationship between serum zinc levels, thyroid hormones and thyroid volume following successful iodine supplementation. | zinc is essential for many biochemical processes and also for cell proliferation. thyroid hormones influence zinc metabolism by affecting zinc absorption and excretion. additionally, zinc deficiency affects thyroid function. the aim of the present study was to evaluate a possible association of zinc levels with thyroid volume, thyroid hormones and thyroid autoantibody levels in healthy subjects, patients with autoimmune thyroid disease (aitd) and patients with nodular goitre following successful ... | 2010 | 20688624 |
| the emergence of translational epidemiology: from scientific discovery to population health impact. | recent emphasis on translational research (tr) is highlighting the role of epidemiology in translating scientific discoveries into population health impact. the authors present applications of epidemiology in tr through 4 phases designated t1-t4, illustrated by examples from human genomics. in t1, epidemiology explores the role of a basic scientific discovery (e.g., a disease risk factor or biomarker) in developing a "candidate application" for use in practice (e.g., a test used to guide interve ... | 2010 | 20688899 |
| invited commentary: the epicenter of translational science. | epidemiology is at the center of translational science. uniquely among biomedical disciplines, the methods and perspective of epidemiology span research from discovery to effective interventions and ultimately to their dissemination and implementation. however, shorthand designations for various phases of translational science, such as "t1, t2, t3, and t4," may be proliferating past the level of their usefulness. it is worthwhile to reflect on the actual nature of the science undertaken by epide ... | 2010 | 20688901 |
| adipocyte-myocyte crosstalk in skeletal muscle insulin resistance; is there a role for thyroid hormone? | to review original research studies and reviews that present data on adipocyte-myocyte crosstalk in the development of skeletal muscle insulin resistance with a specific focus on thyroid hormone. | 2010 | 20689414 |
| gastric adenocarcinoma: is computed tomography (ct) useful in preoperative staging? | although multiple studies testing the accuracy of ct in the preoperative staging of gastric adenocarcinoma have been carried out, their results are controversial. whilst some authors claim that ct is an accurate method for preoperatively staging gastric cancer, others have advocated the contrary. because of this discrepancy we have retrospectively reviewed preoperative ct findings compared with histopathological results in patients with gastric adenocarcinoma. | 2009 | 20689615 |
| thyroid-stimulating hormone receptor and thyroid hormone receptors are involved in human endometrial physiology. | to study the expression, distribution, and function of thyroid-stimulating hormone receptor (tshr) and thyroid hormone receptors (tr) α1, α2, and β1 in human endometrium. | 2011 | 20691434 |
| management of the lymph nodes in penile cancer. | a comprehensive literature study was conducted to evaluate the levels of evidence (les) in publications on the diagnosis and staging of penile cancer. recommendations from the available evidence were formulated and discussed by the full panel of the international consultation on penile cancer in november 2008. the final grades of recommendation (grs) were assigned according to the le of the relevant publications. the following consensus recommendations were accepted. fine needle aspiration cytol ... | 2010 | 20691885 |
| sensory quality of beef from different finishing diets. | beef production under different local husbandry systems might have meat sensory quality implications for the marketing of these products abroad. in order to assess the effect of finishing diet systems on beef quality, a trained sensory taste panel assessed meat aged for 20 days from 80 uruguayan hereford steers that were finished on one of the following diets: t1=pasture [4% of animal live weight (lw)], t2=pasture [3% lw plus concentrate (0.6% lw)], t3=pasture [3% lw plus concentrate (1.2% lw)], ... | 2010 | 20696533 |
| prognostic value and staging categories of anatomic masticator space involvement in nasopharyngeal carcinoma: a study of 924 cases with mr imaging. | to identify the prognostic value and staging categories of masticator space involvement in nasopharyngeal carcinoma (npc) as determined with anatomic criteria ("anatomic masticator space involvement") to determine whether it is necessary for the masticator space described with criteria of the american joint committee on cancer to exclude the medial and lateral pterygoid muscles. | 2010 | 20697119 |
| effect of neoadjuvant anthracycline-taxane-based chemotherapy in different biological breast cancer phenotypes: overall results from the gepartrio study. | in order to explore the effect of neoadjuvant chemotherapy (nact) on clinical mid-course and pathological complete response (pcr) at surgery in different biological breast cancer subtypes. the gepartrio study included 2,072 patients with operable or locally advanced breast cancer. after two cycles with docetaxel, doxorubicin and cyclophosphamide (tac) patients were randomized according to their clinical response. clinical and biological factors were assessed for predicting clinically mid-course ... | 2010 | 20697801 |
| what happens after an elevated psa test: the experience of 13,591 veterans. | the occurrence and timing of prostate biopsy following an elevated prostate-specific antigen (psa) test varied considerably in randomized screening trials. | 2010 | 20697965 |
| development of autonomic dysreflexia after spinal cord injury is associated with a lack of serotonergic axons in the intermediolateral cell column. | autonomic dysreflexia consistently develops in patients and in rats after severe upper thoracic spinal cord injury (sci) as a result of exaggerated spinal sympathetic excitation. in this study we induced episodic hypertension in rats after varying degrees of sci severity to investigate the contribution of serotonergic bulbospinal axons to the development of autonomic dysreflexia after sci. female wistar rats (250-300 g) were used in all experiments in the following groups: (1) uninjured, (2) cli ... | 2010 | 20698759 |
| [thyroid dysfunction in patients with advanced renal cell carcinoma treated with sunitinib: a multifactorial issue]. | several studies have reported the substantial prevalence of sunitinib-induced thyroid dysfunction. however, the underlying mechanism and the benefit of thyroid hormone replacement therapy remain to be determined. to evaluate the effect of sunitinib on thyroid function, we carried out a descriptive study in patients with advanced renal cell carcinoma. | 2010 | 20702151 |
| impact of monocarboxylate transporter-8 deficiency on the hypothalamus-pituitary-thyroid axis in mice. | in patients, inactivating mutations in the gene encoding the thyroid hormone-transporting monocarboxylate transporter 8 (mct8) are associated with severe mental and neurological deficits and disturbed thyroid hormone levels. the latter phenotype characterized by high t3 and low t4 serum concentrations is replicated in mct8 knockout (ko) mice, indicating that mct8 deficiency interferes with thyroid hormone production and/or metabolism. our studies of mct8 ko mice indeed revealed increased thyroid ... | 2010 | 20702572 |
| extracorporeal versus intracorporeal anastomosis after laparoscopic right colectomy for cancer: a case-control study. | the purpose of this study was to compare the short-term outcome (3 months) of laparoscopic right colectomy, between intra- and extracorporeal anastomosis techniques. | 2010 | 20703468 |
| oxidative dna damage: the thyroid hormone-mediated effects of insulin on liver tissue. | thyroid hormone affects glucose homeostasis with its actions between the skeletal muscle and liver and the altered oxidative and non-oxidative glucose metabolism. in our study three chemicals are considered biomarkers associated with oxidative stress for protein modifications were measured; 8-hydroxy-2-deoxyyguanosine (8-ohdg), a major lesion that can be generated by reactive oxygen species for dna damage, protein carbonyl content (pco), products of protein oxidation and advanced oxidation prote ... | 2010 | 20703869 |
| pedicle screw placement in the thoracic spine: a comparison study of computer-assisted navigation and conventional techniques. | the technique of computer-assisted pedicle screw installation and its clinical benefit as compared with conventional pedicle screw installation was evaluated. twenty-two patients had thoracic screw insertion under 3-dimentional computer-assisted navigation (92 screws) and 20 patients under conventional fluoroscopic control (84 screws). the 2 groups were compared for accuracy of screw placement, screw insertion time by postoperative thin-cut computed tomography scans, and statistical analysis. th ... | 2010 | 20704105 |
| isolation and genotyping of acanthamoeba strains from corneal infections in italy. | acanthamoeba keratitis (ak) is a corneal disease caused by members of a genus of free-living amoebae and is associated predominantly with contact lens (cl) use. this study reports 16 cases of culture-proven ak diagnosed in northern italy. genotype identification was carried out with a pcr assay based on sequence analysis of the 18s rrna gene, and sensitivity and specificity were evaluated in comparison with traditional parasitological techniques. a 405 bp region of the 18s rrna gene (asa. ... | 2010 | 20705732 |
| autoantibodies against thyroid hormones and their influence on thyroxine determination with chemiluminescence immunoassay in dogs. | autoantibodies against thyroxin (t4aa) and triiodothyronine (t3aa) are present in dogs with autoimmune thyroiditis and have been reported to interfere with immunoassays. the objectives of this study were to determine the frequency of autoantibodies and to determine whether interference occurs by t4aa, using a non-immunological method (high performance liquid chromatography, hplc) for thyroxin (t4) measurement. based on clinical symptoms, t4 and thyroid stimulating hormone (tsh) concentration, 1, ... | 2010 | 20706025 |
| agreement of immunoassay and tandem mass spectrometry in the analysis of cortisol and free t4: interpretation and implications for clinicians. | objective. to quantify differences in results obtained by immunoassays (ias) and tandem mass spectrometry (msms) for cortisol and free thyroxine (ft4). design & patients. cortisol was measured over 60 minutes following a standard acth stimulation test (n = 80); ft4 was measured over time in two cohorts of pregnant (n = 57), and nonpregnant (n = 28) women. measurements. samples were analyzed with both ia and msms. results. results for cortisol by the two methods tended to agree, but agreement wea ... | 2010 | 20706537 |
| oral symptoms and functional outcome related to oral and oropharyngeal cancer. | purpose: this study aimed to assess: (1) oral symptoms of patients treated for oral or oropharyngeal cancer; (2) how patients rank the burden of oral symptoms; (3) the impact of the tumor, the treatment, and oral symptoms on functional outcome. methods: eighty-nine patients treated for oral or oropharyngeal cancer were asked about their oral symptoms related to mouth opening, dental status, oral sensory function, tongue mobility, salivary function, and pain. they were asked to rank these oral sy ... | 2010 | 20706851 |
| t3 affects expression of collagen i and collagen cross-linking in bone cell cultures. | thyroid hormones (t3,t4) have a broad range of effects on bone, however, its role in determining the quality of bone matrix is poorly understood. in-vitro, the immortalized mouse osteoblast-like cell line mc3t3-e1 forms a tissue like structure, consisting of several cell layers, whose formation is affected by t3 significantly. in this culture system, we investigated the effects of t3 on cell multiplication, collagen synthesis, expression of genes related to the collagen cross-linking process and ... | 2010 | 20707983 |
| biodistribution of technetium-99m pertechnetate after total colectomy in rats. | this study evaluated the effects of total colectomy on the biodistribution of technetium-99m pertechnetate ((99m)tco(4)(-)) on the 28th postoperative day in rats. samples of several organs were harvested for counting the percent of injected radioactivity/g of tissue (%ati/g). the %ati/g in colectomy rats was higher in the stomach and ileum than in sham and controls (p<0.05). increase in mucosa and muscularis size of ileum was observed. colectomy was associated with lower biodistribution in bladd ... | 2010 | 20708943 |
| baseline renal function status limits patient eligibility to receive perioperative chemotherapy for invasive bladder cancer and is minimally affected by radical cystectomy. | to evaluate the proportion of patients with muscle-invasive urothelial carcinoma (uc) who would be eligible to receive cisplatin-based chemotherapy before and after radical cystectomy based on renal function. | 2011 | 20709369 |
| [tnm classification of breast cancer: changes and comments on the 7th edition]. | the 7th edition of the tnm classification includes only minor changes in the main tnm categories for breast cancer. only ductal and lobular carcinoma in situ (dcis, lcis), and isolated paget's disease of the nipple are classified as ptis, but not precursor lesions such as atypical ductal or lobular hyperplasia (adh, alh). ajcc emphasizes that microscopic measurement is the most accurate and preferred method to determine pt in small invasive cancers and stresses the importance of strict adherence ... | 2010 | 20711589 |
| [modified primary stable ventral derotation spondylodesis with halm-zielke instrumentation for the treatment of idiopathic scoliosis]. | surgical technique with an anterior double-rod system for thoracic, thoracolumbar, or lumbar scoliosis. the aim of the system is to correct the coronal plane deformity and normalize the sagittal balance. | 2010 | 20711827 |
| deficits in bladder function following spinal cord injury vary depending on the level of the injury. | loss of bladder function is an important consequence of a spinal cord injury (sci) but is rarely assessed in animal studies of sci. here, we use a simple outcome measure (volume of retained urine) to assess bladder dysfunction over time following moderate contusion injuries at 3 different thoracic levels (t1, t4, or t9) and complete crush injuries (t1 vs. t9). the volume of urine retained in the bladder was measured daily for fourteen days post injury by anesthetizing the animals with isoflurane ... | 2010 | 20713043 |
| allan-herndon-dudley syndrome (ahds) caused by a novel slc16a2 gene mutation showing severe neurologic features and unexpectedly low trh-stimulated serum tsh. | thyroid hormones are known to be essential for growth, development and metabolism. recently mutations in the slc16a2 gene coding for the monocarboxylate thyroid hormone transporter 8, mct8, have been associated with allan-herndon-dudley syndrome (ahds), an x-linked condition characterized by severe mental retardation, dysarthria, athetoid movements, muscle hypoplasia and spastic paraplegia. here we describe in detail the clinical and biochemical features in a boy affected by ahds with severe neu ... | 2010 | 20713192 |
| molecular-genetic identification of t4 bacteriophages in lake baikal. | 2010 | 20714850 | |
| prognostic factors for patients after curative resection for proximal gastric cancer. | the factors influencing the long-term survival of patients with proximal gastric cancer (pgc) after curative resection were investigated. data from 171 patients who underwent curative resection for pgc were retrospectively analyzed. the patients were grouped according to the clinicopathological factors and operative procedures. the tumor depth (t stage) and lymph node metastasis (pn stage) were graded according to the fifth edition of tnm staging system published by uicc in 1997. the metastatic ... | 2010 | 20714884 |
| predictors and survival of synchronous peritoneal carcinomatosis of colorectal origin: a population-based study. | the aim of our study was to provide population-based data on incidence and prognosis of synchronous peritoneal carcinomatosis and to evaluate predictors for its development. diagnosed in 1995-2008, 18,738 cases of primary colorectal cancer were included. predictors of peritoneal carcinomatosis were analysed by multivariable logistic regression analysis. median survival in months was calculated by site of metastasis. in the study period, 904 patients were diagnosed with synchronous peritoneal car ... | 2011 | 20715167 |
| [technical pitfalls of pleural dissection in extrapleural pneumonectomy]. | because extrapleural pneumonectomy (epp) for malignant pleural mesothelioma (mpm) suffers from unsatisfiable risk/benefit ratio, very careful consideration on its indication should be required. epp is a complicated, multi-step surgery that includes pleural dissection, division of hilum, resection of a block of pleura, lung, diaphragm and pericardium, and reconstruction of diaphragm and pericardium. therefore establishment of surgical images of whole procedures before starting surgery is essentia ... | 2010 | 20715442 |
| early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice. | hypopituitary ames dwarf mice were injected either with growth hormone (gh) or thyroxine for a 6-wk period to see whether this intervention would reverse their long life span or the resistance of their cells to lethal stresses. ames dwarf mice survived 987 ± 24 d (median), longer than nonmutant control mice (664 ± 48), but gh-injected dwarf mice did not differ from controls (707 ± 9). fibroblast cells from ames dwarf mice were more resistant to cadmium than cells from nonmutant controls (ld(50) ... | 2010 | 20720157 |
| [the current tnm system for gastrointestinal tumors part i]. | the present review describes the changes in the new 7th edition of the tnm system for tumors of the upper gastrointestinal tract. the description of esophageal tumor localization has been simplified and this new classification now includes tumors of the esophagogastric junction as well as the proximal 5 cm of the stomach. the regional lymph nodes of the esophagus now include celiac lymph nodes, a change which is important for therapeutic decision making. the categories t1 and t4 have been furthe ... | 2010 | 20721558 |