Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| low-temperature t4-like coliphages vb_ecom-vr5, vb_ecom-vr7 and vb_ecom-vr20. | bacteriophages vb_ecom-vr5, vb_ecom-vr7 and vb_ecom-vr20, showing an unusual low-temperature plating profile and producing constantly growing plaques, were isolated from aquatic environments of lithuania. although vb_ecom-vr5, vb_ecom-vr7 and vb_ecom-vr20 resembled phage t4 both in their genome size and in their major structural protein (gp23) pattern, physiological properties of all three phages tested differed significantly from those of t4. with an optimum temperature for plating around 24 de ... | 2010 | 20361343 |
| multifrequency electron spin resonance study of the dynamics of spin labeled t4 lysozyme. | an extensive set of electron spin resonance spectra was obtained over a wide range of frequencies (9, 95, 170, and 240 ghz) and temperatures (2 to 32 degrees c) to explore the dynamic modes of nitroxide-labeled t4 lysozyme in solution. a commonly used nitroxide side chain (r1), or a methylated analogue with hindered internal motion (r2), was substituted for the native side chain at solvent-exposed helical sites, 72 or 131. the spectra at all four frequencies were simultaneously fit with the slow ... | 2010 | 20361789 |
| is pulmonary function damaged by neoadjuvant lung cancer therapy? a comprehensive serial time-trend analysis of pulmonary function after induction radiochemotherapy plus surgery. | we have analyzed short- and long-term variations of pulmonary function in locally advanced non-small cell lung cancer after induction chemoradiotherapy. | 2010 | 20363001 |
| effect of serum estradiol and leptin levels on thyroid function, food intake and body weight gain in female wistar rats. | we evaluated the interplay among estrogen, leptin and thyroid function in the regulation of body mass in female rats. adult female rats were divided into four groups: control (c, sham-operated), ovariectomized (ovx), ovariectomized treated with estradiol benzoate (eb) 0.7 or 14microg/100gbw per day, during 21 days. ovx led to an increase in body mass, food intake and food efficiency (change in body mass as function of the amount of food ingested) which were normalized by the lower eb dose, and d ... | 2010 | 20363238 |
| iterative surgical resection of a recurrent gallbladder carcinoma with long-term survival: report of a case. | gallbladder carcinoma is a rare, but often lethal disease. unfortunately, at the time of diagnosis, patients usually have advanced disease (t3-t4) and long-term survival is dismal, ranging from 5 to 12% in the literature. however, this cancer can be successfully treated when the tumour is organ-confined (t1-t2 tumours), as happens in the case of incidental diagnosis at the time of cholecystectomy for gallstones. here we describe a patient with recurrent gallbladder carcinoma who, treated with it ... | 2010 | 20363997 |
| [factors contributing to gallstone formation and their interaction]. | to study factors contributing to gallstone formation and to elucidate their relationship. | 2010 | 20364691 |
| optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts. | hypothyroidism and thyrotoxicosis are each associated with an increased risk of fracture. although thyroxine (t4) is the predominant circulating thyroid hormone, target cell responses are determined by local intracellular availability of the active hormone 3,5,3'-l-triiodothyronine (t3), which is generated from t4 by the type 2 deiodinase enzyme (d2). to investigate the role of locally produced t3 in bone, we characterized mice deficient in d2 (d2ko) in which the serum t3 level is normal. bones ... | 2010 | 20368437 |
| prognostic accuracy of computed tomography findings for patients with laryngeal cancer undergoing laryngectomy. | the indications for upfront laryngectomy in the management of laryngeal cancer are a functionless larynx and extralaryngeal extension. practically, clinicians rely on imaging to predict which patients will have t4 disease. our goal was to review the accuracy of preoperative computed tomography (ct) scanning in determining the necessity for initial laryngectomy for advanced laryngeal cancer. | 2010 | 20368569 |
| prospective phase ii study of preoperative chemoradiation with capecitabine in locally advanced rectal cancer. | capecitabine is an attractive oral chemotherapeutic agent that has a radiosensitizing effect and tumor-selectivity. this study was performed to evaluate the efficacy and toxicity of preoperative chemoradiation therapy, when used with oral capecitabine, for locally advanced rectal cancer. | 2004 | 20368828 |
| bunching effect in single-molecule t4 lysozyme nonequilibrium conformational dynamics under enzymatic reactions. | the bunching effect, implying that conformational motion times tend to bunch in a finite and narrow time window, is observed and identified to be associated with substrate-enzyme complex formation in t4 lysozyme conformational dynamics under enzymatic reactions. using single-molecule fluorescence spectroscopy, we have probed t4 lysozyme conformational motions under the hydrolysis reaction of polysaccharide of e. coli b cell walls by monitoring the fluorescence resonant energy transfer (fret) bet ... | 2010 | 20369804 |
| dna-binding properties of t4 uvsy recombination mediator protein: polynucleotide wrapping promotes high-affinity binding to single-stranded dna. | to carry out homologous recombination events in the cell, recombination proteins must be able to recognize and form presynaptic filaments on single-stranded dna (ssdna) in the presence of a vast excess of double-stranded dna (dsdna). therefore recombination machineries stringently discriminate between ssdna and dsdna lattices. recent single-molecule studies of bacteriophage t4 recombination proteins revealed that, surprisingly, the uvsy recombination mediator protein binds stronger to stretched ... | 2010 | 20371513 |
| structural, electrochemical, phosphate-hydrolysis, dna binding and cleavage studies of new macrocyclic binuclear nickel(ii) complexes. | new macrocyclic binuclear nickel(ii) complexes have been synthesized by using the bicompartmental mononuclear complex [nil] [3,30-((1e,7e)-3,6-dioxa-2,7-diazaocta-1,7-diene-1,8-diyl)bis(3-formyl-5-methyl-2-diolato)nickel(ii)] with various diamines like 1,2-bis(aminooxy)ethane (l(1)), 1,2-diamino ethane (l(2)), 1,3-diamino propane (l(3)), 1,4-diamino butane (l(4)), 1,2-diamino benzene (l(5)), and 1,8-diamino naphthalene (l(6)). the complexes were characterized by elemental analysis and spectrosco ... | 2010 | 20372706 |
| pre- and post-therapy nodal status equally affects survival of patients with oesophageal squamous cell carcinoma receiving preoperative chemoradiation. | patients with deeply invading (t3-t4) oesophageal cancers usually receive chemoradiotherapy with or without surgery. however, the prognostic significance of pre-therapy and post-therapy lymph node (ln) status remains unclear. we studied 195 patients who received chemoradiotherapy for deeply invading oesophageal cancers (t3-4, n0-1, m0). of these, 105 patients underwent surgery while 90 were treated by chemoradiotherapy alone. of the 105 surgically treated patients, overall survival was significa ... | 2010 | 20372848 |
| prognostic value of lymph node micrometastasis in patients with colorectal cancer in dukes stages a and b (t1-t4, n0, m0). | 30% of patients with colorectal cancer (crc) in dukes stages a and b (t1-t4, n0, m0) present tumor recurrence and die after 5 years follow up. this unexpectedly poor evolution might be attributable to the presence of lymph node micrometastasis undetected in routine examination with haematoxilin-eosine (h&e). | 2010 | 20373832 |
| efficacy of a spray compound containing a pool of collagen precursor synthetic aminoacids (l-proline, l-leucine, l-lysine and glycine) combined with sodium hyaluronate to manage chemo/radiotherapy-induced oral mucositis: preliminary data of an open trial. | oral mucositis (om) is a very frequent and potentially severe complication experienced by patients receiving chemotherapy and/or radiotherapy, which often leads to significant morbidity and mortality, and decreased quality of life, and is very costly. despite its severity and prevalence, there is no standard recognised management today. the aim of this open clinical trial is to evaluate the efficacy and compliance of a new spray compound containing sodium hyaluronate (sh) and a pool of collagen ... | 2010 | 20378002 |
| altered thyroxine metabolism in rainbow trout (oncorhynchus mykiss) exposed to hexabromocyclododecane (hbcd). | hexabromocyclododecane (hbcd) is an additive flame retardant used in consumer and industrial applications. our earlier work suggested that fish exposed to hbcd exhibited an increase in the rate of turnover of thyroxine (t4), the precursor molecule to the active thyroid hormone triiodothyronine (t3). to examine this further, juvenile rainbow trout were held in the laboratory and fed diets containing environmentally relevant concentrations of the individual alpha, beta or gamma isomers. thirty-two ... | 2010 | 20378152 |
| baseline serum testosterone in men treated with androgen deprivation therapy and radiotherapy for localized prostate cancer. | it is believed that men diagnosed with prostate cancer and a low baseline serum testosterone (bst) may have more aggressive disease, and it is frequently recommended they forego testosterone replacement therapy. we used two large phase iii trials involving androgen deprivation therapy and external beam radiation therapy to assess the significance of a bst. | 2010 | 20378270 |
| decompressive surgery in a patient with posttraumatic syringomyelia. | posttraumatic syringomyelia may result from a variety of inherent conditions and traumatic events, or from some combination of these. many hypotheses have arisen to explain this complex disorder, but no consensus has emerged. a 28-year-old man presented with progressive lower extremity weakness, spasticity, and decreased sensation below the t4 dermatome five years after an initial trauma. magnetic resonance imaging (mri) revealed a large, multi-septate syrinx cavity extending from c5 to l1, with ... | 2010 | 20379479 |
| radical cystectomy in patients previously treated for localized prostate cancer. | to present outcomes of a contemporary series of patients undergoing radical cystectomy (rc) for bladder cancer after previous treatment for localized cancer of the prostate (cap). | 2010 | 20381130 |
| increase in vertebral body size in postmenopausal women with osteoporosis. | bone geometry plays a prominent role in bone strength. cross-sectional studies have shown that advancing age is associated with increasing diameter of long bones, related to both periostal apposition and endosteal resorption. however, there are few data provided by prospective studies, especially concerning the changes in vertebral body dimensions. the objective of this prospective study was to measure the changes occurring in the vertebral body size of women with postmenopausal osteoporosis. th ... | 2010 | 20381650 |
| post-challenge hematological evaluation with virulent strain of eimeria tenella in broilers immunized with attenuated strain or sporozoite proteins from homologous strain. | hematological parameters were evaluated in broilers immunized and challenged with eimeria tenella. broiler chickens of hubbard strain, females, coccidian-free, were kept in wire cages and inoculated on the third day. the experiment was designed to include five sorts of treatment with three replicates each. t1 was the negative control group, t2 received 500 attenuated sporulated oocysts by gavage, t3 was the positive control, t4 received 50 μg of sporozoite protein + quil a vaccine, and t5 receiv ... | 2010 | 20385052 |
| quality of life assessment after concurrent chemoradiation for invasive bladder cancer: results of a multicenter prospective study (getug 97-015). | to evaluate bladder preservation and functional quality after concurrent chemoradiotherapy for muscle-invasive cancer in 53 patients included in a phase ii trial. | 2011 | 20385453 |
| coping with the unexpected at surgery. | in lung cancer surgery, it is best to avoid surprises; this requires knowledge of the reliability of preoperative assessment and careful planning. if this has been done, most of the more common situations should be manageable. if there is limited chest wall, mediastinal or n2 node involvement, one should proceed with resection. unanticipated t4 tumors or bulky pn2 disease should not come as a surprise, and such patients should be sent to a more experienced center. one has to be careful to practi ... | 2010 | 20387297 |
| [clinical studies on renal cell carcinoma]. | we reviewed 193 patients of renal cell carcinoma treated at osaka police hospital between 1990 and 2006. | 2010 | 20387516 |
| the center for alternatives to animal testing - europe (caat-eu): a transatlantic bridge for the paradigm shift in toxicology. | the center for alternatives to animal testing - europe (caat-eu) was founded based collaboration between the johns hopkins bloomberg school of public health and the university of konstanz. caat-eu, housed at the university of konstanz, will coordinate transatlantic activities to promote humane science in research and education, and participate, as partner or coordinator, in publicly and privately funded european projects. thomas hartung will serve as program liaison representing johns hopkins un ... | 2010 | 20390240 |
| isolation and characterization of differentially expressed transcripts from the suspension cells of oil palm (elaeis guineensis jacq.) in response to different concentration of auxins. | oil palm suspension cultures were initiated by transferring the gel-like friable embryogenic tissue onto liquid medium supplemented with auxins. in this study, transcripts that were differentially expressed in oil palm suspension cells cultured at different auxin concentrations were examined using suppression subtractive hybridization. total rna was first isolated from oil palm suspension cells proliferated in liquid medium with different hormone concentrations for 6 months. four different hormo ... | 2010 | 20390382 |
| [bone metabolism during substitution therapy of primary hypothyroidism]. | the relation between thyroid hormones and bone metabolism markers in hyperthyroidism is well known. earlier studies indicate the possibility of bone metabolism acceleration during the excessive replacement therapy with l-thyroxin in hypothyroid patients especially in one with other risk factors for bone metabolism impairment. this study evaluated the effect of physiological l-thyroxine treatment on bone metabolism in patient with primary hypothyroidism. | 2009 | 20391734 |
| effects of preoperative immunochemoradiotherapy and chemoradiotherapy on immune responses in patients with rectal adenocarcinoma. | we previously reported that preoperative chemoradiotherapy (crt) combined with intraoperative electron irradiation for ct3/t4 adenocarcinoma of the rectum reduced the local recurrence, with significant improvement of survival. radiotherapy has been reported to reduce immune function. we examined the effects of psk, a protein-bound polysaccharide, concomitant with preoperative crt on immune responses. | 2010 | 20393026 |
| biomechanical analysis of derotation of the thoracic spine using pedicle screws. | biomechanical analysis of derotational load-to-failure of pedicle screw (ps) instrumentation in cadaveric thoracic spinal segments. | 2010 | 20393385 |
| [(18)f]fluorodeoxyglucose positron emission tomography/computed tomography (pet/ct) physiologic imaging of choroidal melanoma: before and after ophthalmic plaque radiation therapy. | to evaluate changes in [(18)f]fluorodeoxyglucose positron emission tomography/computed tomography (pet/ct) standardized uptake values (suv) in uveal melanoma before and after plaque brachytherapy. | 2011 | 20395070 |
| peripheral blood dendritic cells and vascular endothelial growth factor in oral squamous cell carcinoma: correlation analysis and in vitro study. | vascular endothelial growth factor (vegf) may cause functional deficiency in dendritic cells (dcs) in vitro. the roles of peripheral blood dendritic cells (pbdcs) and vegf in patients with oral squamous cell carcinoma (oscc) are not well understood. the authors analysed the correlation between vegf and pbdc in 81 oscc patients. they assessed the effect of vegf on dc function in vitro. vegf levels were significantly increased in oscc patients compared with control subjects (p < 0.05), but pbdc le ... | 2010 | 20395112 |
| male breast cancer: a survey at the helsinki university central hospital during 1981-2006. | the purpose was to analyze the behavior of male breast cancer. | 2010 | 20397767 |
| the burden of comorbidity and the c-reactive protein levels in nonthyroidal illness syndrome with metabolic syndrome and atherosclerosis-related cardiovascular complications. | thyroid hormones undergo significant modifications during severe illnesses, and the low t3 levels are the hallmark of nonthyoidal illness syndrome (ntis), due to a reduced extrathyroidal conversion from t4. we examined 41 patients with ntis by a modified cumulative illness rating scale (cirs) and the measurement of ft3, ft4, tsh, and c-reactive protein (crp) levels. fifty-seven control subjects were enrolled. we observed reduced ft3 and increased ft4 levels in ntis patients (p < 0.05). the cirs ... | 2010 | 20398024 |
| comparison of uncalibrated arterial pressure waveform analysis with continuous thermodilution cardiac output measurements in patients undergoing elective off-pump coronary artery bypass surgery. | monitoring of cardiac output is required during anesthesia for off-pump coronary artery bypass (opcab) surgery. recently, flotrac, a new device for arterial pressure waveform analysis for cardiac output (apco) monitoring without external calibration, was developed. the authors have compared apco with stat-mode continuous cardiac output (scco) in patients undergoing opcab surgery. | 2010 | 20399114 |
| radioiodine plus recombinant human thyrotropin do not cause acute airway compression and are effective in reducing multinodular goiter. | recombinant human thyrotropin (rhtsh) reduces the activity of radioiodine required to treat multinodular goiter (mng), but acute airway compression can be a life-threatening complication. in this prospective, randomized, double-blind, placebo-controlled study, we assessed the efficacy and safety (including airway compression) of different doses of rhtsh associated with a fixed activity of 131i for treating mng. euthyroid patients with mng (69.3 +/- 62.0 ml, 20 females, 2 males, 64 +/- 7 years) r ... | 2010 | 20401438 |
| indirect reference intervals estimated from hospitalized population for thyrotropin and free thyroxine. | to establish indirect reference intervals from patient results obtained during routine laboratory work as an alternative to laborious and expensive producing of their own reference range values according to international instructions. | 2010 | 20401954 |
| the c-terminal domain of yeast high mobility group protein hmo1 mediates lateral protein accretion and in-phase dna bending. | the saccharomyces cerevisiae high mobility group protein hmo1 has two dna binding domains, box a and box b, and a lysine-rich c-terminal extension. among other functions, hmo1 has been implicated as a component of the rna polymerase i transcription machinery. we report here that hmo1 promotes dna apposition as evidenced by its stimulation of end-joining in the presence of t4 dna ligase. analysis of truncated hmo1 variants shows that enhanced dna end-joining requires the c-terminal domain but tha ... | 2010 | 20402481 |
| metabolic effects of second-generation antipsychotics in bipolar youth: comparison with other psychotic and nonpsychotic diagnoses. | despite known metabolic effects of second-generation antipsychotics (sgas) on children and adolescents, comparative effects in youth with different diagnoses remain underreported. we compared differences in metabolic changes three months after starting treatment with sgas in youth with bipolar disorder and with other psychotic and nonpsychotic disorders. | 2010 | 20402710 |
| [hand-assisted laparoscopic nephrectomy in challenging cases]. | to assess the outcome of hand-assisted laparoscopic nephrectomy in patients with significant complicating clinical factors. | 2010 | 20403284 |
| absent cd44v6 expression is an independent predictor of poor urothelial bladder cancer outcome. | cd44v6 is a cell surface protein involved in cell migration, cell adhesion, tumor progression and metastatic spread. we evaluated its role as a molecular marker for urothelial bladder cancer. | 2010 | 20403620 |
| ion-trap mass spectrometry for determination of 3,5,3'-triiodo-l-thyronine and 3,5,3',5'-tetraiodo-l-thyronine in neonatal rat cardiomyocytes. | our short report describes a method employing electrospray ion-trap mass spectrometry (ms) connected to a reversed phase (c(8)) hplc system for monitoring of 3,5,3'-triiodo-l-thyronine (t3) and its precursor 3,5,3',5'-tetraiodo-l-thyronine (t4) in neonatal rat cardiomyocytes. the experimental protocol allows simultaneous analysis of the free thyroid hormones in nanomolar concentration range and enables observation of their distribution in cultivation medium over time. the method is a useful tool ... | 2010 | 20403674 |
| cryoem structure of hsp104 and its mechanistic implication for protein disaggregation. | hsp104 is a ring-forming aaa+ machine that recognizes both aggregated proteins and prion-fibrils as substrates and, together with the hsp70 system, remodels substrates in an atp-dependent manner. whereas the ability to disaggregate proteins is dependent on the hsp104 m-domain, the location of the m-domain is controversial and its exact function remains unknown. here we present cryoem structures of two hsp104 variants in both crosslinked and noncrosslinked form, in addition to the structure of a ... | 2010 | 20404203 |
| use of the proposals of the international association for the study of lung cancer in the forthcoming edition of lung cancer staging system to predict long-term prognosis of operated patients. | to evaluate the utility of the proposals of the international association for the study of lung cancer (iaslc) in the forthcoming 7th edition of lung cancer staging system to classify patients submitted to radical surgical resection of non-small cell lung cancer and to compare their value in predicting long-term prognosis with the existing 6th edition of the american joint committee on cancer (ajcc)/union internationale contre le cancer (uicc) tnm classification. | 2010 | 20404615 |
| the role of adjuvant chemotherapy in patients with locally advanced (pt3, pt4a) and/or lymph node-positive bladder cancer. | to report the long-term follow up of patients with locally advanced bladder cancer treated with either adjuvant chemotherapy with gemcitabine/cisplatin (gc) or methotrexate, vinblastine, epirubicin, and cisplatin (mvec) or no additional treatment after radical cystectomy, to examine various survival endpoints and factors associated with long-term survival. | 2010 | 20405206 |
| prognostic factors in node-negative colorectal cancer: a retrospective study from a prospective database. | there is a need to identify a subgroup of high-risk patients with node-negative colorectal cancer who have a poor long-term prognosis and may benefit from adjuvant therapies. the aim of this study was to evaluate the prognostic impact of clinical and pathological parameters in a retrospective study from a prospective, continuous database of homogenously treated patients. | 2010 | 20405293 |
| iodine supplementation in pregnancy. | people of all ages can be affected by iodine deficiency, however, pregnant women and children are especially at a high risk. because of changes that occur in maternal thyroid hormone economy during pregnancy and the potential unfavorable effects of iodine deficiency on the offspring, an adequate dietary iodine intake throughout the pregnancy is highly important. therefore, the world health organization, united nations children's fund and international council for the control of iodine deficiency ... | 2009 | 20405646 |
| [effect of preparations melatonin and epitalon on the age-related dynamics of thyrotrophic activity of the hypophysis and thyroid gland function in different light regimes]. | the influence of different light regimes (standard lightning--12 hours light/ 12 hours darkness; natural light regime of the north-west of russia; constant darkness and constant lightning), melatonin and epitalon on the thyrotrophic activity of hypophysis and on the function of thyroid gland was studied. it has been found out that the maximum values of free thyroxin and triiodothyronine in blood were observed in the conditions of constant lightning and the minimal values--in the conditions of li ... | 2009 | 20405731 |
| one-step, zero-background ligation-independent cloning intron-containing hairpin rna constructs for rnai in plants. | *the hairpin-based rna interference (rnai) technique plays an important role in exploring gene function in plants. although there are several methods for making hairpin rna (hprna) constructs, these methods usually need multiple relatively laborious, time-consuming or high-cost cloning steps. here we describe a one-step, zero-background ligation-independent cloning (oz-lic) method for making intron-containing hprna (ihprna) constructs by our vector prnai-lic. *to generate the ihprna constructs w ... | 2010 | 20406406 |
| primary antiphospholipid syndrome and thyroid involvement. | data on thyroid involvement in primary antiphospholipid syndrome are scarce and inconclusive. | 2010 | 20407389 |
| development of a high-throughput screening platform for dna 3'-phosphatases and their inhibitors based on a universal molecular beacon and quantitative real-time pcr. | dna 3'-phosphatases play a unique role in the repair of strand breaks induced by dna damaging agents, such as ionizing radiation or oxidative stress. in this paper, we present an efficient detection system for rapid screening of dna 3'-phosphatases and their inhibitors. a unique template substrate has been designed to hybridize with the universal molecular beacon (u-mb), and the detection process is carried out in a quantitative real-time pcr. the method is successfully applied to monitor the ac ... | 2010 | 20408165 |
| [disorders in thyroid hormone metabolism]. | the levels of the serum thyroid hormone (free t4 and free t3) are determined not only by thyroid hormone synthesis/secretion but also by their metabolism. thyroid hormone metabolism is mediated by three selenoproteins, selenodeiodinase type 1, 2, and 3 (d1, d2, and d3), the expression and function of which are tightly regulated in a tissue-specific manner. among them, d2 increases and d3 decreases the intracellular thyroid hormone levels, whereas d1 seems to play a role as a housekeeping/scaveng ... | 2010 | 20408442 |
| four different ways of alternative transcripts generation mechanism in adra1a gene. | the adra1a (alpha-1-adrenergic receptor) gene is one of the members of g protein-coupled receptor superfamily. alternative splicing of this gene was known to generate four transcript variants which code four isoforms with various c-terminal regions. in this study, we conducted expression analysis and evolutionary characterization of alternative transcripts of the adra1a gene. in total, 10 alternative transcripts were identified using experimental approaches and in silico analysis. among them, 6 ... | 2010 | 20410666 |
| long level (t4-l1) spinal epidural abscess in a diabetic patient - a case report -. | spinal epidural abscesses are uncommon, but potentially devastating and often fatal. they can be found in normal patients, but they are more prevalent in immunocompromised patients, such as intravenous drug users, diabetics, chronic renal failure patients, pregnant women, and others. timely diagnosis and treatment are the keys to optimizing outcome. traditionally, treatment has comprised parenteral antibiotics and possible surgical intervention, such as decompression by pus drainage. we treated ... | 2008 | 20411144 |
| non-invasive measurement of thyroid hormone in feces of a diverse array of avian and mammalian species. | we developed and validated a non-invasive thyroid hormone measure in feces of a diverse array of birds and mammals. an i(131) radiolabel ingestion study in domestic dogs coupled with high pressure liquid chromatography (hplc) analysis, showed that peak excretion in feces occurred at 24-48h post-ingestion, with i(131)-labelled thyroid hormone metabolites excreted primarily as triiodothyronine (t3) and relatively little thyroxine (t4), at all excretion times examined. the immunoreactive t3 profile ... | 2010 | 20412809 |
| comparative study of the effects of experimentally induced hypothyroidism and hyperthyroidism in some brain regions in albino rats. | thyroid hormones (ths) play a crucial role in the development and physiological functioning of different body organs especially the brain. therefore, the objective of this study was to show the histopathological effects of the different thyroid states on some brain regions (cerebrum and cerebellum) and the skeletal features of their newborns during the postnatal development from the 1st to 3rd week. the female white albino rats were allocated into 3 groups as follows: the experimental hypothyroi ... | 2010 | 20412848 |
| subclinical hypothyroidism in childhood. | subclinical hypothyroidism (sh) is defined as an elevated thyroid stimulating hormone (tsh) in association with a normal total or free thyroxine (t4) or triiodothyronine (t3). it is frequently encountered in both neonatology and general paediatric practice; however, its clinical significance is widely debated. currently there is no broad consensus on the investigation and treatment of these patients; specifically who to treat and what cut-off level of tsh should be used. this paper reviews the a ... | 2011 | 20413616 |
| superficial siderosis of the central nervous system: secondary progression despite successful surgical treatment, mimicking amyotrophic lateral sclerosis. case report and review. | superficial siderosis of the central nervous system is a rare disorder with hemosiderin deposition in the spinal and cranial leptomeninges and subpial layer, mostly from repetitive subarachnoid hemorrhage. progressive sensorineural deafness, cerebellar ataxia, and pyramidal signs comprise the typical clinical presentation. we describe a 47-year-old patient, who showed initial 2-year improvement after successful occlusion of an intradural bleeding source at t4. secondary progression of symptoms w ... | 2010 | 20414791 |
| [cloning of id4 gene expression regulation promoter and subcloning of recombinant id4 promoter luciferase reporter]. | the present study was aimed to clone id4 gene promoter and upstream regulatory region, and to construct a series of recombinant promoter-luciferase reporter for exploring the mechanism of id4 gene expression regulation. methods and results: the upstream 5' flanking sequence of 2242 bp from transcriptional start site (tss) and downstream 5' non-coding region of 212 bp on id4 gene were searched out and downloaded from human genome databank of ncbi using whole length of id4 gene cdna as a probe; on ... | 2010 | 20416180 |
| weight-of-evidence analysis of human exposures to dioxins and dioxin-like compounds and associations with thyroid hormone levels during early development. | thyroid hormones play a critical role in the proper development of brain function and cell growth. several epidemiological studies have been conducted to assess potential associations between pre- and post-natal exposure to dioxins or dioxin-like compounds (dlcs) and the levels of circulating thyroid hormones during early development. dioxins and dlcs include chlorinated dibenzo-p-dioxins, chlorinated dibenzofurans, and mono- and non-ortho polychlorinated biphenyls (pcbs). we identified a total ... | 2010 | 20416351 |
| transverse maxillary distraction in patients with periodontal pathology or insufficient tooth anchorage using custom-made devices. | we present our experience using modified hyrax devices for treating transverse deficiencies of the maxilla in adult patients with periodontal pathology or insufficient tooth anchorage. the surgical technique, clinical indications, and results are discussed. | 2010 | 20417007 |
| developmental regulation of gene expression in the thyroid gland of xenopus laevis tadpoles. | thyroid hormones (th) are the primary morphogen regulating amphibian metamorphosis. however, knowledge about molecular mechanisms regulating thyroid gland activity in anuran tadpoles is very scarce. in this study, we characterized gene expression profiles in thyroids of xenopus laevis tadpoles during spontaneous metamorphosis. using real-time pcr, elevated expression of slc5a5, tpo, tshr, and sar1a mrnas was detected at late prometamorphic and climax stages. for dio2 and dio3 but not dio1, devel ... | 2010 | 20417211 |
| ampullary tumours (ampullomas) in the elderly--an interdisciplinary problem. | ampullary cancer is one of the periampullary tumours with better prognosis, but relapses occur early in some patients. this study was carried out to assess whether pancreatoduodenectomy (pde, whipple operation) could be a safe therapeutic procedure for elderly patients with periampullary tumours. | 2010 | 20418556 |
| [excessive shivering after remifentanil infusion in a muscular karate player for tracheal resection and construction surgery]. | a 22-year-old muscular karate player was diagnosed to have a tracheal tumor with a diameter of 2.8 cm that existed 2 cm under the glottis and occupied 60% of his trachea. he was scheduled for trachea resection and construction surgery. after awake-fiber intubation, anesthesia was maintained by continuous infusion of propofol and remifentanil, together with thoracic epidural anesthesia (t4-5). after 431 minutes of surgery, 50 mm of trachea was rejected. to prevent him from extending his neck, the ... | 2010 | 20420146 |
| iscr regulates rnase ls activity by repressing rnla transcription. | the escherichia coli endoribonuclease ls was originally identified as a potential antagonist of bacteriophage t4. when the t4 dmd gene is defective, rnase ls cleaves t4 mrnas and antagonizes t4 reproduction. this rnase also plays an important role in rna metabolisms in e. coli. rnla is an essential gene for rnase ls activity, but the transcriptional regulation of this gene remains to be elucidated. an fe-s cluster protein, iscr, acts as a transcription factor and controls the expression of genes ... | 2010 | 20421606 |
| active and passive mechanisms of helicases. | in this work, we discuss the active or passive character of helicases. in the past years, several studies have used the theoretical framework proposed by betterton and julicher [betterton, m.d. and julicher, f. (2005) opening of nucleic-acid double strands by helicases: active versus passive opening. phys. rev. e, 71, 11904-11911.] to analyse the unwinding data and assess the mechanism of the helicase under study (active versus passive). however, this procedure has given rise to apparently contr ... | 2010 | 20423906 |
| link between pericardial effusion and attenuation of qrs voltage in patients with hypothyroidism. | to determine the clinical correlates of pericardial effusion (pe) and a low-voltage electrocardiogram (ecg) in patients with primary hypothyroidism. | 2010 | 20424451 |
| immediate post-mastectomy breast reconstruction followed by radiotherapy: risk factors for complications. | the objective is to prospectively determine the factors responsible for reconstruction failure and capsular contracture in mastectomized breast cancer patients who underwent immediate two-stage breast reconstruction with a tissue expander and implant, followed by radiotherapy. this is a multicenter, prospective, non-randomized study. between february 1998 and september 2006, we prospectively examined 141 consecutive patients, each of which received an implant after mastectomy, followed by chest ... | 2010 | 20424909 |
| simultaneous determination of l- and d-t4 using a sequential injection analysis/sensors system. | a sequential injection analysis system was selected for the simultaneous determination of l- and d-t4 in raw material and pharmaceutical products, because of the highest precision and accuracy, the lower consumption of sample and buffer, and the flexibility of selecting different buffers accordingly with the type of sensors utilized as detectors. an amperometric biosensor based on d-amino acid oxidase was used as detector for d-t4 and an immunosensor based on anti-l-t4 was used as detector for l ... | 2010 | 20426752 |
| carbocyclic potential dna minor groove binders and their biological evaluation. | the biological evaluation of carbocyclic minor groove binders 1-6 is described. the cytotoxicity of the obtained compounds was tested on mda-mb-231 breast cancer cells. the mechanism of action of compounds 1-6 was studied employing the topoisomerase i/ii inhibition assay and ethidium displacement assay using pbr322. determination of association constants was done using calf thymus dna, t4 coliphage dna, poly(da-dt)(2), and poly(dg-dc)(2). the effect of compounds 1-6 on the amidolytic activity of ... | 2010 | 20429779 |
| assessment of oral toxicity and safety of pentamethylchromanol (pmcol), a potential chemopreventative agent, in rats and dogs. | 2,2,5,7,8-pentamethyl-6-chromanol (pmcol) was administered by gavage in rats for 28 days at dose levels of 0, 100, 500, and 2000mg/kg/day. pmcol administration induced decreases in body weight gains and food consumption, hepatotoxicity (increased tbili, alb, alt, tp; increased relative liver weights; increased t4 and tsh), nephrotoxicity (increased bun and bun/creat, histopathology lesions), effect on lipid metabolism (increased chol), anemia, increase in wbc counts (total and differential), coa ... | 2010 | 20430063 |
| neonatal screening for congenital hypothyroidism: a retrospective hospital based study from bahrain. | neonatal screening programs for congenital hypothyroidism (ch) are now widespread in developed countries. | 2010 | 20432804 |
| late-onset circulatory dysfunction after thyroid hormone treatment in an extremely low birth weight infant. | late-onset circulatory dysfunction (lcd) is a phenomenon specific to premature infants and is characterized by sudden onset of hyponatremia, hypotension, oliguria and non-physiological weight gain, without an obvious cause, in premature infants after stabilization of circulation and respiration. the cause of lcd is not clear, but adrenal insufficiency in premature infants is a severe syndrome because steroid replacement therapy is often essential to treat the symptoms. we report a rare case of a ... | 2010 | 20432818 |
| capromab pendetide scanning has a potential role in optimizing patient selection for salvage cryosurgical ablation of the prostate. | to evaluate an algorithm using capromab pendetide scanning (cps) and prostate biopsy to select appropriate patients with biochemical recurrence (bcr) after radiation therapy (rt) for salvage cryosurgical ablation of the prostate (csap) and to avoid premature androgen deprivation therapy (adt); and to estimate the local salvage success rate for patients with high-risk clinical features. | 2010 | 20434196 |
| isolation and identification of acanthamoeba from taiwan spring recreation areas using culture enrichment combined with pcr. | in the study, 52 spring water samples were collected from three hot spring recreation areas in northern taiwan and acanthamoebae were isolated from 11 samples (21.2%) on two hot spring recreation areas and mainly present in the hot spring water, hot tubs and wastewater. the most frequently identified acanthamoeba genotype was t15, followed by t6, and then t5. genotype t1, t2, t3 and t4 were detected once, respectively. the presence or absence of acanthamoeba within the spring water samples showe ... | 2010 | 20434423 |
| effects of extender and equilibration time on post-thaw motility and membrane integrity of cryopreserved gyr bull semen evaluated by casa and flow cytometry. | the objectives of the present study were to investigate the effects of three equilibration times (0, 2, and 4h) and two extenders (tris or bioxcell) for cryopreservation of bull semen. semen from 12 gyr bulls was cryopreserved using an automated freezing machine. there were significant interactions between equilibration times and extenders for sperm motility and membrane integrity. the control treatment (0h equilibration) had the lowest values (p<0.05) for total (mot) and progressive motilities ... | 2010 | 20434857 |
| effect of laboratory practices on the incidence rate of congenital hypothyroidism. | newborn screening (nbs) laboratories in the united states expanded their programs to include primary congenital hypothyroidism (ch) in the 1970s. an increase in the national ch-incidence rate since 1987 has been reported. our goal was to analyze national data reported by state nbs programs and laboratories from 1991 to 2000 to determine the extent to which changing laboratory methods might have contributed to the reported rise in ch-incidence rate. | 2010 | 20435717 |
| [functional and oncological outcomes of surgical treatment of outer ear skin cancer]. | results of the surgical treatment of external ear skin cancer in 71 patients are evaluated. based on the tnm classification, the patients were allocated to the following groups: t1 - 25 (35.2%) patients, t2 - 23 (32.4%) patients, t3 - 11 (15.5%), t4 - 12 (16.9%) patients. eight patients underwent total removal of the auricle and 26 ones its resection. extensive resection of the tumour in 36 patients was immediately followed by plastic reconstruction of the resulting defect on the outer ear with ... | 2010 | 20436426 |
| phenotypic characterization and genomic analysis of the shigella sonnei bacteriophage sp18. | a novel bacteriophage that infects shigella sonnei was isolated from the gap river in korea, and its phenotypic and genomic characteristics were investigated. the virus, called sp18, showed morphology characteristic of the family myoviridae, and phylogenetic analysis of major capsid gene (gp23) sequences classified it as a t4-like phage. based on host spectrum analysis, it is lytic to s. sonnei, but not to shigella flexneri, shigella boydii or members of the genera escherichia and salmonella. py ... | 2010 | 20437154 |
| goitrogenic anions, thyroid-stimulating hormone, and thyroid hormone in infants. | environmental exposure of infants to perchlorate, thiocyanate, nitrate, might interfere with thyroid function. u.s. women with higher background perchlorate exposure have higher thyroid-stimulating hormone (tsh) and lower thyroxine (t4). there are no studies with individual measures of thyroid function and these goitrogens available in infants. | 2010 | 20439182 |
| the first 50s: can we achieve acceptable results in vestibular schwannoma surgery from the beginning? | vestibular schwannoma surgery requires a profound knowledge of anatomy and long-standing experience of surgical skull base techniques, as patients nowadays requests high-quality results from any surgeon. this educes a dilemma for the young neurosurgeon as she/he is at the beginning of a learning curve. the presented series should prove if surgical results of young skull base surgeons are comparable respecting carefully planned educational steps. | 2010 | 20440629 |
| the use of pectoralis major myocutaneous flap as "salvage procedure" following intraoral and oropharyngeal cancer excision. | the benefits and superiority of free flaps for head and neck reconstruction are well recognized. however, in some instances, especially in elderly and critical patients with advanced intraoral and oropharyngeal cancers or in patients with underlying systemic syndromes (i.e. uncontrolled diabetes, cardio-pulmonary failure, renal insufficiency), the use of pectoralis mayor myocutaneous flap may be a preferable option with fewer risks for the patient. | 2010 | 20444340 |
| flexible intramedullary nailing of a displaced transverse sternal fracture associated with a flexion-compression injury of the thoracic spine. | a case report. | 2010 | 20445472 |
| spontaneous resolution of a traumatic cervicothoracic epidural hematoma presenting with transient paraplegia: a case report. | case description. | 2010 | 20445476 |
| [surgical treatment and outcome of multiple primary lung cancers]. | we assessed the selection of the type of pulmonary resection, operative morbidity, mortality and the outcome of our 14 cases who underwent surgical treatment for multiple primary lung cancer. eleven cases underwent lobectomy with limited surgery, 3 cases underwent combination of limited surgery. only 1 case had prolonged air leakage after surgery, but other cases had no postoperative complication and there was no operative death. the survival rate was higher than that of t4 (metastasis to the sa ... | 2010 | 20446600 |
| [assessment of surgical treatment for lung cancer with pericardial or left atrial invasion]. | we evaluated surgical results for the patients who underwent pulmonary resection combined with pericardial or left atrial resection due to locally advanced non-small cell lung cancer (nsclc). seven patients who underwent pericardial resection (t3 group) and 4 patients who underwent resection of the left atrium (t4 group) were included in this study, and clinical findings and prognosis were evaluated. eight patients underwent pneumonectomy, and others underwent lobectomy or bilobectomy. histology ... | 2010 | 20446602 |
| natural history of subclinical hyperthyroidism in elderly patients with tsh between 0.1 and 0.4 miu/l: a prospective study. | one important aspect in the decision to treat or not elderly patients with subclinical hyperthyroidism (sch) is the risk of progression to overt hyperthyroidism (oh). | 2010 | 20447066 |
| the pharmacodynamic equivalence of levothyroxine and liothyronine: a randomized, double blind, cross-over study in thyroidectomized patients. | the substitution of liothyronine (l-t3) for levothyroxine (l-t4) is commonly employed during thyroid hormone (th) withdrawal in preparation for diagnostic and therapeutic interventions on thyroid cancer patients. presently, only limited data are available on the l-t3 for l-t4 therapeutic substitution. objective to characterize the pharmcodynamic equivalence of l-t3 and l-t4. | 2010 | 20447070 |
| interaction with dna of a heteronuclear [na2cu4] coordination cluster obtained from the assembly of two hydroxo-bridged [cu(ii)2] units by a dimeric sodium nitrate template. | the heteronuclear [na(2)cu(4)(bemp)(2)(oh)(2)(no(3))(2)(oh(2))(4)] x 5 h(2)o (1 x 5h(2)o; h(3)bemp: 2,6-bis-[(2-hydroxyethylimino)-methyl]-4-methyl-phenol) cluster has been synthesized in aqueous-methanol at room temperature and structurally characterized. the water soluble complex is obtained from the template assembly of two [cu(2)(bemp)(oh)] neutral fragments through their weak oxophillic interactions with two interconnected nano(3) units as core. four [na(2)cu(4)] units form a metal-organic ... | 2009 | 20449195 |
| the impact of speech therapy on asthma and allergic rhinitis control in mouth breathing children and adolescents. | to determine the impact of speech therapy on asthma and allergic rhinitis control in mouth breathing children and adolescents. | 2010 | 20449526 |
| prolactin inhibition at mid-lactation influences adiposity and thyroid function in adult rats. | maternal hypoprolactinemia at the end of lactation (a precocious weaning model) increases milk leptin transfer and results in overweight, leptin resistance, and secondary hypothyroidism at adulthood. we studied the effects of prolactin (prl) inhibition during mid-lactation (a partial malnutrition model) on milk leptin transfer, leptinemia, body composition, and thyroid function. lactating rats were treated with bromocryptine (bro, 1 mg/twice daily) or saline on days 7, 8, and 9 of lactation. off ... | 2010 | 20449792 |
| [progress in tripterygium wilfordiiand its bioactive components in the field of pharmacodynamics and pharmacology]. | in the trials of multi-glycoside of tripterygium wilfordii (gtw) in the field of pharmacodynamics, some clinical characteristics and symptoms, such as proteinuria, hematuria,joint pain, and skin damage, could be improved in the patients with various diseases including proliferative glomerulonephritis, lupus nephritis, rheumatoid arthritis, psoriasis and other immune-related diseases. in this review, it has been also reported to discuss the effects of gtw and triptolide (t4), which is a bioactive ... | 2010 | 20450057 |
| [atp-sensitive potassium channel function during the progression of pressure overload heart failure in rats]. | to investigate k(atp) channel function of cardiomyocytes isolated from the left ventricular wall of rats with or without abdominal aortic constriction at different time points under normal or simulated ischemic conditions. | 2010 | 20450563 |
| discrepancy between clinical staging through bimanual palpation and pathological staging after cystectomy. | objectives: in muscle invasive bladder cancer (mibc), careful clinical staging is essential for patient counseling and decision-making. bimanual palpation (bp) is an integral part and guideline advice of clinical staging. until now, however, the value of bp has never been studied. with this study, we aim to determine the accuracy of clinical staging through bp. methods: detailed clinical data were collected from a population-based series of 1,409 patients with mibc, diagnosed between 1989 and 20 ... | 2010 | 20451418 |
| hif-1α and vegf are associated with disease progression in esophageal carcinoma. | hypoxia inducible factor-1alpha (hif-1α) is a transcription factor that regulates the transcription of genes associated with cell proliferation and angiogenesis. the purpose of this study is to clarify the correlation of hif-1α protein expression with vascular endothelial growth factor (vegf) and inducible (inos), endothelial (enos), and neuronal nitric oxide synthase (nnos) expression in esophageal tumors. additionally, vascular density in tumor tissue was assessed. | 2011 | 20451923 |
| independent changes of thyroid hormones in blood plasma and cerebrospinal fluid after melatonin treatment in ewes. | the authors measured the effects of exogenous melatonin treatment on the concentrations of total (t) and free (f) fractions of thyroxine (t4) and triiodothyronine (t3) in cerebrospinal fluid (csf) and blood plasma as well as the expression of their binding/transporter protein, transthyretin (ttr), in the choroid plexus of ewes from may to august. melatonin implantation in may and july mainly prevented the decrease in plasma for ft3 and tt3 exhibited in untreated group, and induced a limited decr ... | 2010 | 20452012 |
| effects of magnesium on central arterial compliance in preeclampsia. | the objective of the study was to investigate the effect of mgso4 infusion on central arterial compliance, using radial artery applanation tonometry in women with preeclampsia. | 2010 | 20452485 |
| the effects of hypothyroidism on strength-duration properties of peripheral nerve. | axonal injury and/or demyelination commonly result in peripheral mononeuropathy, polyneuropathy or entrapment neuropathies in hypothyroidism. in this study, we aimed to measure the strength-duration time constants (sdtc) of motor and sensory fibres in patients with primary hypothyroidism before and after hormone replacement treatment. the motor and sensory sdtc and rheobase of 14 patients with overt hypothyroidism (tsh>10mg/ml, free t4<normal range, with positive thyroid autoantibodies) and 10 a ... | 2010 | 20452625 |
| impact of radiation dose on locoregional control and survival on squamous cell carcinoma of anal canal. | to perform a systematic analysis of clinical data of presentation, treatment, outcome, toxicity, survival and other associated prognostic factors of the patients of anal canal who received treatment at our hospital. | 2010 | 20452695 |
| in vivo assessment and potential diagnosis of xenobiotics that perturb the thyroid pathway: proteomic analysis of xenopus laevis brain tissue following exposure to model t4 inhibitors. | as part of a multi-endpoint systems approach to develop comprehensive methods for assessing endocrine stressors in vertebrates, differential protein profiling was used to investigate expression patterns in the brain of the amphibian model (xenopus laevis) following in vivo exposure to a suite of t4 synthesis inhibitors. we specifically address the application of two dimensional polyacrylamide gel electrophoresis (2d page), isobaric tags for relative and absolute quantitation (itraq) and lc-ms/ms ... | 2010 | 20452843 |
| t cell immunoglobulin- and mucin-domain-containing molecule-4 attenuates concanavalin a-induced hepatitis by regulating macrophage. | tim-4 is expressed primarily on apcs, including macrophages, and has been shown to play a critical role in t cell regulation. however, it remains unclear whether tim-4 also plays a role in the regulation of macrophage functions. in the present study, we investigated the effects of tim-4 on macrophage activity in con a-induced hepatitis in mice. we found that high levels of tim-4 expression were associated with a diminished serum level of alt in con a-induced hepatitis. in addition, adoptive tran ... | 2010 | 20453106 |