Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| role of intrinsic airway neurons in ozone-induced airway hyperresponsiveness in ferret trachea. | exposure to ozone (o(3)) enhances airway responsiveness, which is mediated partly by the release of substance p (sp) from airway neurons. in this study, the role of intrinsic airway neurons in o(3)-induced airway responses was examined. ferrets were exposed to 2 ppm o(3) or air for 1 h. reactivity of isolated tracheal smooth muscle to cholinergic agonists was significantly increased after o(3) exposure, as were contractions to electrical field stimulation at 10 hz. pretreatment with cp-99994, a ... | 2001 | 11408454 |
| maternal odours induce fos in the main but not the accessory olfactory bulbs of neonatal male and female ferrets. | previous research demonstrated that exposing gonadectomized adult ferrets to odours in oestrous female bedding induced nuclear fos-immunoreactivity (fos-ir; a marker of neuronal activity) in the main as opposed to the accessory olfactory system in a sexually dimorphic fashion, which was further augmented in both sexes by treatment with testosterone propionate. ferrets are born in an altricial state and presumably use maternal odour cues to locate the nipples until the eyes open after postnatal ( ... | 2001 | 11412342 |
| organization of the inner retina following early elimination of the retinal ganglion cell population: effects on cell numbers and stratification patterns. | the present study has examined the effects of early ganglion cell elimination upon the organization of the inner retina in the ferret. the population of retinal ganglion cells was removed by optic nerve transection on the second postnatal day, and retinas were subsequently studied in adulthood. numbers of amacrine and bipolar cells were compared in the nerve-transected and nerve-intact retinas of operated ferrets, while stratification patterns within the inner plexiform layer were compared in th ... | 2001 | 11417798 |
| helicobacter mustelae lipid a structure differs from that of helicobacter pylori. | the lipid a structure of the gram-negative bacterium helicobacter mustelae, a ferret gastric pathogen responsible for the onset of gastric diseases in its host, was investigated. two variant lipid a structures were found in the same strain. one structure contained a bisphosphorylated beta-(1-->6)-linked d-glucosamine backbone disaccharide with hydroxytetradecanoic acid in amide linkages. unlike the structure described for the lipid a of the related human helicobacter pylori gastric pathogen, whi ... | 2001 | 11418100 |
| differences in the number of micronucleated erythrocytes among young and adult animals including humans. spontaneous micronuclei in 43 species. | in our previous report we speculated about the possibility that some species had high levels of spontaneous micronucleated erythrocytes (mne) just in a juvenile stage, this is, that the mne diminish as the reticuloendothelial system matures. here we show this effect in species including rat, rabbit, pig, dog, cat, gray squirrel, lion, giraffe, white-tailed deer, opossum and even human. the number of spontaneous mne that we found in 43 species is shown, and the proportions of polychromatic and no ... | 2001 | 11423355 |
| astrocyte invasion and vasculogenesis in the developing ferret retina. | we studied the time course of astrocyte invasion and blood vessel formation in the developing ferret retina using glial fibrillary acidic protein (gfap)-immunohistochemistry for astrocytes and isolectin b4 histochemistry for blood vessels. as in other mammals, strongly gfap positive astrocytes invade the ferret retina from the optic nerve. at birth, strongly gfap positive astrocytes have reached about 22% of the distance between optic disc and outer retinal edge whereas weakly gfap positive proc ... | 2000 | 11428047 |
| the contribution of sensory experience to the maturation of orientation selectivity in ferret visual cortex. | sensory experience begins when neural circuits in the cerebral cortex are still immature; however, the contribution of experience to cortical maturation remains unclear. in the visual cortex, the selectivity of neurons for oriented stimuli at the time of eye opening is poor and increases dramatically after the onset of visual experience. here we investigate whether visual experience has a significant role in the maturation of orientation selectivity and underlying cortical circuits using two for ... | 2001 | 11429605 |
| differential impact of predator or immobilization stressors on central corticotropin-releasing hormone and bombesin-like peptides in fast and slow seizing rat. | lines of rats selectively bred for amygdala excitability, as reflected by kindling rates in response to electrical stimulation, also exhibit differences in tests of anxiety. inasmuch as corticotropin-releasing hormone (crh) and bombesin (bn) have been associated with anxiety, regional levels and release of these peptides, as well as plasma adrenocorticotropic hormone (acth) and corticosterone, were assessed in 'slow' and 'fast' seizing rats following predator exposure (ferret) or immobilization. ... | 2001 | 11430862 |
| establishment of the cat flea (ctenocephalides felis felis) on the ferret (mustela putorius furo) and its control with imidacloprid. | as the ferret, mustela putorius furo l. (carnivora: mustelidae), is becoming increasingly popular as a pet animal and as it is susceptible to the cat-flea, ctenocephalides felis felis bouché (siphonaptera: pulicidae), an experimental model was established for evaluating insecticidal treatments on this host. a high establishment rate (76.7-91.8%) was recorded when 60 unfed adult c. felis were placed on ferrets. this provided an adequate infestation for chemotherapeutic evaluation without causing ... | 2001 | 11434557 |
| caffeine stimulates the reverse mode of na/ca2+ exchanger in ferret ventricular muscle. | this study investigated the effect of caffeine on the sarcolemmal mechanisms involved in intracellular calcium control. ferret cardiac preparations were treated with ryanodine and thapsigargin in order to eliminate the sarcoplasmic reticulum (sr) function. this treatment abolished caffeine contracture irreversibly in normal solution. the perfusion with k-free medium that blocked the na+--k+ pump resulted in a recovery of slow relaxing caffeine contractures similar to na-free contractures. the am ... | 2001 | 11437737 |
| cell-type specific dendritic contacts between retinal ganglion cells during development. | the extent of a neuron's dendritic field defines the region within which information is processed. the dendritic fields of functionally distinct on and off center retinal ganglion cells (rgcs) form separate mosaics across the retina. within each mosaic, neighboring dendritic fields overlap by a constant amount, sampling the visual field with the appropriate coverage. contact-mediated lateral inhibition between neighboring rgcs has long been thought to regulate both the extent and overlap of dend ... | 2001 | 11438943 |
| direction selectivity of excitatory and inhibitory neurons in ferret visual cortex. | direction selectivity is a characteristic feature of neurons in the visual cortex of higher mammals. excitatory and inhibitory cortical neurons receive different patterns of synaptic connections resulting in different receptive field properties. we have analyzed the direction tuning of excitatory and inhibitory neurons of ferret visual cortex using single unit recordings. direction tuning was constant among neurons in a vertical column. the majority (> 80%) of excitatory (regular spiking) neuron ... | 2001 | 11447352 |
| an ultrastructural study of germ cells during ovarian differentiation in torpedo marmorata. | an ultrastructural investigation, performed on embryos, neonates, subadult and adult females, demonstrated that in torpedo marmorata oogenesis occurs very early in life and continues, in its proliferative phase, also after birth. clusters of early meiotic cells were already evident in the ovarian cortex of 6-cm-long embryos, as well as in the ovary of newborns and three-month-old young. conversely, in the ovaries of subadult and adult females, all the germ cells present were organized into folli ... | 2001 | 11455532 |
| the ferret's vomeronasal organ and accessory olfactory bulb: effect of hormone manipulation in adult males and females. | the male ferret, a carnivore, was recently shown to possess a vomeronasal organ (vno). we compared the morphology of the vno and its associated accessory olfactory bulb (aob) in male and female ferrets that were killed in adulthood. the volume and surface area of the vno neuroepithelium were similar in adult gonadectomized male and female ferrets regardless of whether they were treated with testosterone propionate (tp) or oil vehicle. an aob was localized bilaterally in the medial caudal part of ... | 2001 | 11455537 |
| wildlife disease reservoirs: the epidemiology of mycobacterium bovis infection in the european badger (meles meles) and other british mammals. | mycobacterium bovis infection has been confirmed in a wide range of mammals hosts throughout the world. the european badger (meles meles) and the brushtail possum (trichosurus vulpecula) are implicated as significant sources of infection for domestic cattle in the uk and new zealand respectively. the risk of transmission of infection between a wildlife population and domestic animals will be determined by both the epidemiology of the disease and the ecology of the host. in the uk, surveys by the ... | 2001 | 11463223 |
| in vitro control of mycobacterium bovis by macrophages. | mycobacterium bovis is frequently seen inside macrophages in vivo. the outcome of m. bovis infection depends on t cell interactions with macrophages, however mycobacteria are thought to be relatively resistant to macrophage killing. little is known about the immunological mechanisms which control intracellular growth of m. bovis, and in the absence of t cell help the organism is capable of intracellular survival and replication. we have investigated the role of macrophages in controlling growth ... | 2001 | 11463232 |
| organization of the neurons of origin of the descending pathways from the ferret superior colliculus. | the superior colliculus (sc), through its descending projections to the brainstem and spinal cord, is involved in initiating sensory-driven orienting behaviors. ferrets are carnivores that hunt both above and below ground using visual (and auditory) cues in the daylight but non-visual cues in darkness and in subterranean environments. the present investigation sought to determine whether the ferret sc shows organizational features similar to those found in other visually dominant animals (e.g. c ... | 2001 | 11463476 |
| mycobacterium bovis infection in wildlife in new zealand. | bovine tuberculosis (tb) is the most important disease of livestock in new zealand, and it puts at risk the nation's trade in dairy, beef and venison products. elimination of the disease from livestock is based on a herd test and slaughter programme and carcass inspection at abbatoirs. however, this programme has not been as successful as expected, because the disease also occurs in wild or feral animals acting as vectors of the disease to livestock. brushtail possums are the major wildlife vect ... | 2001 | 11466031 |
| nares occlusion eliminates heterosexual partner selection without disrupting coitus in ferrets of both sexes. | using an airtight y maze and a new method to induce peripheral anosmia in ferrets, we assessed the contribution of conspecific odors, either alone or in combination with visual and auditory signals, to heterosexual partner preference. sexually naive ferrets were gonadectomized and treated with sex steroids, after which their nares were either bilaterally occluded using dental impression material or were sham-occluded. behavioral and histological evidence suggested that nares occlusion blocked ac ... | 2001 | 11466455 |
| disseminated mycobacterium celatum (type 3) infection in a domestic ferret (mustela putorius furo). | a 4-year-old male ferret (mustela putoriusfuro) had a 6-month history of weight loss and gradual development of depression and coughing. necropsy findings included pale gray tissue around the distal trachea, multiple nodules in the lungs, a single nodule in the stomach wall, gray foci in the liver, and enlarged lymph nodes. histologic examination revealed multifocal to coalescing granulomatous inflammation in the trachea, lungs, stomach, liver, and lymph nodes, with acid-fast bacteria in epithel ... | 2001 | 11467483 |
| effect of endogenous catecholamine on myocardial stunning in a simulated ischemia model. | during ischemia, large amounts of catecholamine are released to the myocardium from the sympathetic nerve endings in the heart. it has not been clearly shown whether the released catecholamine has detrimental or beneficial effects on postischemic myocardial contractile function. the aim of the present study was to investigate the effect of endogenous catecholamine released during ischemia on myocardial contractile function, using ferret papillary muscles in a stimulated ischemia model. papillary ... | 2001 | 11468020 |
| transdentinal stimulation of reactionary dentinogenesis in ferrets by dentine matrix components. | trans-dentinal stimulation of reactionary dentinogenesis may be mediated through cellular signalling by bio-active components released from the dentine matrix during injury. understanding of these processes will be important to guide dentinal repair activity following restorative surgery. the purpose of this study was to investigate the effects of implanting isolated dentine matrix proteins within cavity preparations on dentinal repair activity and odontoblast survival using a controlled experim ... | 2001 | 11472806 |
| investigation of the effects of ym-31636, a novel 5-ht3 receptor agonist, on defecation in normal and constipated ferrets. | we examined the effects of ym-31636 (2-(1h-imidazol-4-ylmethyl)-8h-indeno[1,2-d]thiazole monofumarate), a newly synthesized 5-ht(3) receptor agonist, on defecation in normal and constipated ferrets, and evaluated it as an agent against constipation. ym-31636 facilitated defecation without inducing diarrhea or emetic episodes. this effect occurred within 1 h after oral administration, mostly within 30 min, whereas sodium picosulfate, a widely used laxative, tended to increase the frequency of def ... | 2001 | 11476761 |
| nucleotide sequence and polymerase chain reaction/restriction fragment length polymorphism analyses of aleutian disease virus in ferrets in japan. | two ferrets with spontaneous aleutian disease (ad) were found in japan. the diagnosis was verified by polymerase chain reaction (pcr) amplification of part of the capsid gene specific to ad virus (adv). the nucleotide sequences (365 bp in length) of the amplified fragments from the 2 ferrets differed by a single nucleotide, producing an amino acid alteration. compared with other types of adv, these isolates had 96% sequence similarity to a published ferret adv (fadv) in contrast to <91% homology ... | 2001 | 11478607 |
| skin diseases of ferrets. | this article describes the most common diseases that affect the integumentary system of ferrets. emphasis is placed on diagnosis and treatment of each disease. | 2001 | 11480365 |
| translating developmental time across mammalian species. | conservation of the order in which events occur in developing mammalian brains permits use of regression theory to model the timing of neural development. following a small adjustment to account for a systematic variability in primate cortical and limbic systems, the model is used to generate a 95-event/nine-species matrix that predicts aspects of neurogenesis and axonal outgrowth in the brains of developing mice, hamsters, rats, spiny mice, rabbits, ferrets, cats, monkeys, and humans. although ... | 2001 | 11483296 |
| effects of volatile anesthetics on ryanodine-treated ferret cardiac muscle. | the volatile anesthetics halothane, isoflurane, and sevoflurane depress myocardial contractility by decreasing transsarcolemmal ca2+ influx, ca2+ release from the sarcoplasmic reticulum, ca2+ sensitivity of the contractile proteins, and cross-bridge performance. the aim of this study is to assess and compare the effects of halothane, isoflurane, and sevoflurane on contractility in conditions in which sarcoplasmic reticulum ca2+ release is abolished by pretreatment with ryanodine. ferret right ve ... | 2001 | 11483870 |
| ifetroban sodium: an effective txa2/pgh2 receptor antagonist. | this review presents a comprehensive discussion on the chemistry, pharmacokinetics, and pharmacodynamics of ifetroban sodium, a new thomboxane a2/prostaglandin h2 receptor antagonist. thromboxane a2 is an arachidonic acid product, formed by the enzyme cyclooxygenase. in contrast to other cyclooxygenase products, thromboxane a2 has been shown to be involved in vascular contraction and has been implicated in platelet activation. in general, results of clinical studies and animal experiments indica ... | 2001 | 11484065 |
| evaluation of epidural morphine for postoperative analgesia in ferrets (mustela putorius furo). | we evaluated the analgesic efficacy of epidural morphine for relieving postoperative pain in domestic ferrets by evaluating behavior and fecal cortisol concentrations. the 12 laboratory-reared, intact, female, domestic ferrets were anesthetized then underwent ovariohysterectomy and bilateral anal sacculectomy. using a double-blind procedure, we provided epidural morphine (0.1 mg/kg) to six ferrets and epidural saline (0.1 ml/ferret) to the remaining animals prior to surgery. compared to the anim ... | 2000 | 11487250 |
| effects of ym905, a novel muscarinic m3-receptor antagonist, on experimental models of bowel dysfunction in vivo. | we investigated the effects of ym905 [(+)-(1s,3'r)-quinuclidin-3'-yl 1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate monosuccinate], a new orally active muscarinic m3-receptor antagonist, on bowel dysfunction in vivo using experimental models that reproduce the symptoms present in irritable bowel syndrome (ibs). ym905 potently inhibited restraint stress-induced fecal pellet output in fed rats (ed50: 4.0 mg/kg) and diarrhea in fasted rats (ed50: 1.7 mg/kg), with similar potencies to the inh ... | 2001 | 11488427 |
| imiquimod-elicited emesis is mediated by the area postrema, but not by direct neuronal activation. | the immunomodulator, imiquimod, has been shown to have antiviral and antitumor properties in animal models. it also has been reported to alter cytokine levels in both animals and humans. however, because imiquimod appeared to be emetic, studies were conducted to determine the degree of sensitivity, and the pathways involved. subcutaneous administration of > or = 10 mg/kg imiquimod to ferrets elicited emesis with latencies as short as 2'; 12 and 15 mg/kg were optimal doses. emetic responsiveness ... | 2001 | 11489353 |
| axonal regeneration of mouse retinal ganglion cells by peripheral nerve transplantation; a quantitative study. | purpose: retinal ganglion cells (rgcs) of adult mammals can regenerate their axons along a segment of the peripheral nerve (pn) that is transplanted to the cut optic nerve. there have been many trials of pn transplantation to induce axonal regeneration of rgcs in adult rodents, cats and ferrets. however, because of the technical difficulty in transplant operation, pn transplantation in adult mice has not been carried out in spite of the availability of many kinds of gene-manipulated animals. her ... | 2000 | 11490074 |
| cross-bridge and calcium behavior in ferret papillary muscle in different thyroid states. | x-ray diffraction studies were made using synchrotron radiation on ferret right ventricular papillary muscle under three different thyroid states: euthyroidism, hyperthyroidism, and hypothyroidism. the latter two states were induced by treatment with l-thyroxine and methimazole, respectively. the x-ray equatorial reflections were recorded at a time resolution of 10 ms to study the mass movement of myosin cross-bridges from thick to thin filaments. the myosin isomer content was measured by gel el ... | 2001 | 11492956 |
| ferrets as a transmission model for influenza: sequence changes in ha1 of type a (h3n2) virus. | ferrets were used as an animal model to study whether controlled transmission of type a influenza is similar to human transmission when sequence changes in ha1 are used as the outcome. ferrets were infected initially with a/sydney/5/97 (h3n2) or a/la/1/87 (h3n2) intranasally, and transmission chains were established by housing infected ferrets with noninfected ferrets with no influenza antibody titer against the infecting virus. ferrets infected with a/sydney were seronegative for a/sydney and a ... | 2001 | 11494159 |
| listening through different ears alters spatial response fields in ferret primary auditory cortex. | the localization of sounds in space is based on spatial cues that arise from the acoustical properties of the head and external ears. individual differences in localization cue values result from variability in the shape and dimensions of these structures. we have mapped spatial response fields of high-frequency neurons in ferret primary auditory cortex using virtual sound sources based either on the animal's own ears or on the ears of other subjects. for 73% of units, the response fields measur ... | 2001 | 11495972 |
| enterotoxigenic escherichia coli infection in captive black-footed ferrets. | enterotoxigenic escherichia coli with genes for heat stabile toxins sta and stb was isolated from the gastrointestinal tract and multiple visceral organs of three adult and three juvenile black-footed ferrets (mustela nigripes) that died in a captive breeding colony between 24 may 1998 and 2 july 1998. similar isolates were obtained from rectal swabs of one adult and one juvenile that were clinically ill. all were fed a diet composed of mink chow, raw rabbit meat, beef liver powder, blood meal a ... | 2001 | 11504237 |
| microtubule disassembly increases endothelial cell barrier dysfunction: role of mlc phosphorylation. | endothelial cell (ec) barrier regulation is critically dependent on cytoskeletal components (microfilaments and microtubules). because several edemagenic agents induce actomyosin-driven ec contraction tightly linked to myosin light chain (mlc) phosphorylation and microfilament reorganization, we examined the role of microtubule components in bovine ec barrier regulation. nocodazole or vinblastine, inhibitors of microtubule polymerization, significantly decreased transendothelial electrical resis ... | 2001 | 11504682 |
| histochemical phenotypes of von ebner's gland of ferret and their functional implications. | von ebner's gland of ferret was examined by means of light microscopy, protein, mucosubstance and enzyme histochemistry, and neurohistology. acinar cells were replete with granules containing neutral mucosubstances and disulphides, and showed strong diffuse acid phosphatase activity and weak granular staining for peroxidase. staining for cytochrome oxidase, succinate dehydrogenase, and nadh and nad(p)h dehydrogenases was also seen. basolateral plasmalemma of acinar cells showed weak, ouabain-sen ... | 2001 | 11508341 |
| transneuronal tracing of neural pathways controlling abdominal musculature in the ferret. | abdominal musculature participates in generating a large number of behaviors and protective reflexes, although each abdominal muscle is frequently activated differentially during particular motor responses. for example, rectus abdominis has been reported to play less of a role in respiration than other abdominal muscles, such as transversus abdominis. in the present study, the inputs to transversus abdominis and rectus abdominis motoneurons were determined and compared using the transneuronal tr ... | 2001 | 11520490 |
| antioxidant vitamins prevent cardiomyocyte apoptosis produced by norepinephrine infusion in ferrets. | norepinephrine (ne) induces apoptosis in cultured neonatal rat myocytes. to determine whether this change occurred in intact animals after chronic subhypertensive doses of ne, and whether the effect was mediated via oxidative stress produced by ne, we measured myocyte apoptosis and apoptotic gene proteins in ferrets receiving chronic ne with and without antioxidant vitamin treatment. | 2001 | 11530107 |
| serum amyloid p component inhibits influenza a virus infections: in vitro and in vivo studies. | serum amyloid p component (sap) binds in vitro ca(2+)-dependently to several ligands including oligosaccharides with terminal mannose and galactose. we have earlier reported that sap binds to human influenza a virus strains, inhibiting hemagglutinin (ha) activity and virus infectivity in vitro. these studies were extended to comprise five mouse-adapted influenza a strains, two swine influenza a strains, a mink influenza a virus, a ferret influenza a reassortant virus, a influenza b virus and a p ... | 2001 | 11530187 |
| in vivo optical mapping of epileptic foci and surround inhibition in ferret cerebral cortex. | the population of neurons participating in an epileptiform event varies from moment to moment. most techniques currently used to localize epileptiform events in vivo have spatial and/or temporal sampling limitations. here we show in an animal model that optical imaging based on intrinsic signals is an excellent method for in vivo mapping of clinically relevant epileptiform events, such as interictal spikes, ictal onsets, ictal spread and secondary homotopic foci. in addition, a decrease in the o ... | 2001 | 11533712 |
| gaba(b) and nmda receptors contribute to spindle-like oscillations in rat thalamus in vitro. | thalamic slice preparations, in which intrathalamic connectivity between the reticular nucleus and relay nuclei is maintained, are capable of sustaining rhythmic burst firing activity in rodents and ferret. these in vitro oscillations occur spontaneously in the ferret and have frequencies (6-10 hz) within the range of sleep spindles observed in vivo. in the rat, mainly lower frequency (2-4 hz) oscillations, evoked under conditions of low bath [mg(2+)] and/or gaba(a) receptor blockade, have been ... | 2001 | 11535683 |
| activity in the ferret: oestradiol effects and circadian rhythms. | the present study was conducted to determine whether oestradiol increases activity in the european ferret (mustela furo), whether this effect is sexually dimorphic, and whether a 24-h rhythm is present in the ferret's daily activity. the activity of male and female adult, postpubertally gonadectomized ferrets was monitored while they were maintained singly on a 13:11 light-dark cycle, before and after implantation with oestradiol-17 beta. gonadectomized male and female ferrets exhibited equal ... | 1985 | 11539816 |
| behavioral endpoints for radiation injury. | the relative behavioral effectiveness of heavy particles was evaluated. using the taste aversion paradigm in rats, the behavioral toxicity of most types of radiation (including 20ne and 40ar) was similar to that of 60co photons. only 56fe and 93nb particles and fission neutrons were significantly more effective. using emesis in ferrets as the behavioral endpoint, 56fe particles and neutrons were again the most effective; however, 60co photons were significantly more effective than 18 mev elec ... | 1994 | 11539983 |
| [signs of estrus in an ovariectomized ferret]. | signs of oestrus, including vulvar swelling and alopecia are frequently seen in ovariectomized ferrets. between 1997 and 1999, 25 ovariectomized ferrets presented with symptoms of vulvar swelling and symmetric alopecia at the university clinic of companion animals. in 18 of these animals, ovarian remnants were found. to prevent failure to remove all ovarian tissue in the ferret, thorough identification of the ovaries, which are surrounded by large fat deposits, is necessary. the incision should ... | 2001 | 11544927 |
| plasma hormone levels and central c-fos expression in ferrets after systemic administration of cholecystokinin. | posterior pituitary hormone secretion and central neural expression of the immediate-early gene product c-fos was examined in adult ferrets after intravenous administration of cck octapeptide. pharmacological doses of cck (1, 5, 10, or 50 microg/kg) did not induce emesis, but elicited behavioral signs of nausea and dose-related increases in plasma vasopressin (avp) levels without significant increases in plasma oxytocin (ot) levels. cck activated neuronal c-fos expression in several brain stem v ... | 2001 | 11557633 |
| laryngeal mask versus endotracheal tube in a ferret model. | acquired subglottic stenosis in infants is a difficult iatrogenic problem with notable morbidity, primarily caused by prolonged endotracheal intubation. the laryngeal mask airway (lma) is a recently developed, alternative airway device that does not contact the subglottis. to explore the possibility of preventing subglottic stenosis, we compared the endotracheal tube (ett) and the lma in terms of the incidence and severity of glottic and subglottic injury resulting from prolonged intubation in t ... | 2001 | 11558758 |
| distribution of the muscarinic k+ channel proteins kir3.1 and kir3.4 in the ventricle, atrium, and sinoatrial node of heart. | the functionally important effects on the heart of ach released from vagal nerves are principally mediated by the muscarinic k+ channel. the aim of this study was to determine the abundance and cellular location of the muscarinic k+ channel subunits kir3.1 and kir3.4 in different regions of heart. western blotting showed a very low abundance of kir3.1 in rat ventricle, although kir3.1 was undetectable in guinea pig and ferret ventricle. although immunofluorescence on tissue sections showed no la ... | 2001 | 11561006 |
| effects of volatile anesthetics on stiffness of mammalian ventricular muscle. | to assess the effects of halothane, isoflurane, and sevoflurane on cross bridges in intact cardiac muscle, electrically stimulated (0.25 hz, 25 degrees c) right ventricular ferret papillary muscles (n = 14) were subjected to sinusoidal load oscillations (37-182 hz, 0.2-0.5 mn peak to peak) at the instantaneous self-resonant frequency of the muscle-lever system. at resonance, stiffness is proportional to m * omega(2) (where m is equivalent moving mass and omega is angular frequency). dynamic stif ... | 2001 | 11568137 |
| pre-clinical and clinical investigation of the safety of a novel adjuvant for intranasal immunization. | nasalflu berna is a trivalent influenza virus vaccine for active immunization against influenza by the nasal route. it consists of influenza virosomes which are formulated from inactivated influenza strains and heat-labile toxin from aseptic escherichia coli bacteria strain, as an adjuvant (hlt). the results of preclinical studies in ferrets, baboons, minipigs, mice and rabbits are presented here, and issues concerning route of administration, mechanism of action (preventing the disease and halt ... | 2001 | 11587809 |
| formation of a direction map by projection learning using kohonen's self-organization map. | in this paper, we propose a modification of kohonen's self-organization map (som) algorithm. when the input signal space is not convex, some reference vectors of som can protrude from it. the input signal space must be convex to keep all the reference vectors fixed on it for any updates. thus, we introduce a projection learning method that fixes the reference vectors onto the input signal space. this version of som can be applied to a non-convex input signal space. we applied som with projection ... | 2001 | 11592621 |
| two phases of increased cell death in the inner retina following early elimination of the ganglion cell population. | neurons in the inner nuclear layer (inl) of the vertebrate retina undergo considerable programmed cell death during development, but the determinants of this cell death remain largely unknown. the present study examines the role of retinal ganglion cells in support of inl neurons in the developing ferret retina. the retinal ganglion cell population was eliminated by optic nerve transection at postnatal day (p) 2, and the incidence of cell death was examined using terminal deoxytransferase dutp n ... | 2001 | 11596065 |
| behavior of mustela putorius furo (the domestic ferret). | behavior patterns exhibited by the domestic ferret, although similar to its wild cousins, are distinctly domestic in nature. domestic ferrets use many different types of behaviors, including body posturing, animations, vocalizations, and scent markings. these behaviors may differ somewhat from ferret to ferret. the domestic ferret is best understood by observation and recognition of its behavior patterns and interactions as it plays and communicates with both humans and animals within its home e ... | 2001 | 11601109 |
| cannabinoids inhibit emesis through cb1 receptors in the brainstem of the ferret. | marijuana and other cannabinoids are effective anti-emetics. despite ongoing controversy over their usage, the receptor distribution and the site of the anti-emetic action of these compounds are not known. our aim was to investigate whether the cannabinoid 1 receptor (cb1r) and endocannabinoids play a role in the anti-emetic action of cannabinoids. | 2001 | 11606489 |
| mechanisms underlying developmental changes in the firing patterns of on and off retinal ganglion cells during refinement of their central projections. | patterned neuronal activity is implicated in the refinement of connectivity during development. calcium-imaging studies of the immature ferret visual system demonstrated previously that functionally separate on and off retinal ganglion cells (rgcs) develop distinct temporal patterns of spontaneous activity as their axonal projections undergo refinement. off rgcs become spontaneously more active compared with on cells, resulting in a decrease in synchronous activity between these cell types. this ... | 2001 | 11606654 |
| guardians, ferrets and defilers of the treasure: the masson-freudians controversy. | 1989 | 11621786 | |
| effects of cp-99, 994, a tachykinin nk(1) receptor antagonist, on abdominal afferent vagal activity in ferrets: evidence for involvement of nk(1) and 5-ht(3) receptors. | the effect of cp-99, 994, a tachykinin nk(1) receptor antagonist, on abdominal vagal afferent nerve activity in the ferret was investigated. substance p (1 microg/kg, i.v.) increased vagal afferent activity by 449.0+/-51.9% and this was reduced to 145.9+/-5.7% (p<0.01) by pre-treatment with cp-99, 994 (1 mg/kg, i.v.), and to 149.5+/-1.5% (p<0.001) by granisetron (1 mg/kg, i.v.), a 5-ht(3) receptor antagonist. in addition, the increase in vagal nerve activity induced by 5-ht (25 microg/kg, i.v., ... | 2001 | 11675038 |
| morphological changes in the neuronal substrate for the optokinetic reflex in albino ferrets. | albino mammals show very characteristic deficits in their optokinetic system, and albino ferrets are even optokinetically blind. to investigate the neuronal causes for this defect we compared the morphology of retinal slip cells in the pretectal nucleus of the optic tract and the dorsal terminal nucleus of the accessory optic system (not-dtn) in pigmented and albino ferrets (mustela putorius furo) using retrograde tracing techniques. after tracer injections into the inferior olive, equal numbers ... | 2001 | 11681310 |
| how plastic is spatial hearing? | the location of a sound source is derived by the auditory system from spatial cues present in the signals at the two ears. these cues include interaural timing and level differences, as well as monaural spectral cues generated by the external ear. the values of these cues vary with individual differences in the shape and dimensions of the head and external ears. we have examined the neurophysiological consequences of these intersubject variations by recording the responses of neurons in ferret p ... | 2001 | 11694724 |
| spontaneous activity in developing ferret visual cortex in vivo. | multi-electrode extracellular recordings in area 17 of awake behaving ferrets were conducted to characterize the pattern of spontaneous activity in the developing visual cortex before eye opening. a linear array of 16 microwire electrodes was used to record extracellular neuronal activity across a 3.2 mm strip of visual cortex between postnatal days 22 and 28. whereas synchronous bursts of activity were observed at all recording sites, cross-correlation analysis revealed that the timing of spike ... | 2001 | 11698602 |
| effects of functional septoplasty on the facial growth of ferrets. | to determine the effects of functional septoplasty on the facial growth of ferrets. | 2001 | 11701076 |
| gaba(b)r expressed on vagal afferent neurones inhibit gastric mechanosensitivity in ferret proximal stomach. | gaba(b)-receptor (gaba(b)r) agonists reduce transient lower esophageal sphincter relaxation (tlesr) and reflux episodes through an action on vagal pathways. in this study, we determined whether gaba(b)r are expressed on vagal afferent neurones and whether they modulate distension-evoked discharge of vagal afferents in the isolated stomach. vagal mehanoreceptor activity was recorded following distensions of the isolated ferret proximal stomach before and after perfusion with the gaba(b)r-selectiv ... | 2001 | 11705755 |
| beta(3)-adrenoceptor agonists for the treatment of frequent urination and urinary incontinence: 2-[4-(2-[[(1s,2r)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl)phenoxy]-2-methylpropionic acid. | in a search for novel analogues of beta(3)-adrenoceptor (ar) agonists relaxing the bladder for treatment of urinary dysfunction, 2-[4-(2-[[(1s,2r)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl)phenoxy]-2-methylpropionic acids (1a-e), into which a fibrate-like structure had been incorporated, were synthesised. compound 1a was found to be a selective beta(3)-ar agonist in functional assays using the ferret detrusor (beta(3)-ar), rat uterus (beta(2)-ar), and rat atrium (beta(1)-ar); beta( ... | 2001 | 11711302 |
| a cardiac dihydropyridine receptor ii-iii loop peptide inhibits resting ca(2+) sparks in ferret ventricular myocytes. | 1. we studied the effect of a peptide (ac-10c) on cardiac ryanodine receptor (ryr) opening. this decapeptide (kkerklarta) is a fragment of the cardiac dihydropyridine receptor (dhpr) from the cytosolic loop between the second and third transmembrane domains (ii-iii loop). studies were carried out in ferret ventricular myocytes by simultaneously applying ruptured-patch voltage clamp and line-scan confocal microscopy with fluo-3 to measure intracellular [ca(2+)] ([ca(2+)](i)) and ca(2+) sparks. 2. ... | 2001 | 11711557 |
| central antiemetic effects of as-8112, a dopamine d2, d3, and 5-ht(3) receptor antagonist, in ferrets. | the involvement of a central mechanism in the antiemetic effect of as-8112 ((r)-5-bromo-n-(1-ethyl-4-methylhexahydro-1h-1,4-diazepin-6-yl)-2-methoxy-6-methylamino-3-pyridinecarboxamide x 2 fumarate), a novel and potent dopamine d2, d3, and 5-ht(3) receptor antagonist, was investigated in ferrets. intracerebroventricularly administered as-8112 dose dependently inhibited r(+)-7-oh-dpat (r(+)-7-hydroxy-2-(n,n-di-n-propylamino) tetraline)-induced emesis (id(50); 0.11 microg/kg, i.c.v.). in addition, ... | 2001 | 11730730 |
| are goats naturally resistant to gastric helicobacter infection? | gastric helicobacter species are widespread and have been reported in wild and domestic mammals of different dietary habits such as humans, dogs, cats, macaques, mice, cheetahs, ferrets, swine and cattle. all have been associated with gastric pathologies. recently, gastric helicobacter species were shown to be widespread in cattle and swine in europe, and there is a report of helicobacter pylori in sheep in italy. however, there are no reports of helicobacter infection in the goat, another impor ... | 2002 | 11731164 |
| calponin is required for agonist-induced signal transduction--evidence from an antisense approach in ferret smooth muscle. | 1. the present study was undertaken to determine whether calponin (cap) participates in the regulation of vascular smooth muscle contraction and, if so, to investigate the mechanism. 2. by pcr homology cloning, the cdna sequence of ferret basic (h1) cap was determined and phosphorothioate antisense and random oligonucleotides were synthesized and introduced into strips of ferret aorta by a chemical loading procedure. 3. treatment of ferret aorta with cap antisense oligonucleotides resulted in a ... | 2001 | 11731586 |
| piloleiomyosarcoma in seven ferrets. | in each of seven ferrets (mustela putorius furo) with leiomyosarcoma, a single dermal mass was identified and biopsied. each mass consisted of a well-demarcated but nonencapsulated proliferation of large spindle- to strap-shaped cells arranged in interwoven bundles. the cells resembled the smooth muscle cells of the adjacent arrector pili muscles, but with marked nuclear pleomorphism. immunohistochemical staining for smooth muscle actin, desmin, and vimentin was positive and staining for myoglob ... | 2001 | 11732806 |
| infusion of nerve growth factor (ngf) into kitten visual cortex increases immunoreactivity for ngf, ngf receptors, and choline acetyltransferase in basal forebrain without affecting ocular dominance plasticity or column development. | intracerebroventricular or intracortical administration of nerve growth factor (ngf) has been shown to block or attenuate visual cortical plasticity in the rat. in cats and ferrets, the effects of exogenous ngf on development and plasticity of visual cortex have been reported to be small or nonexistent. to determine whether locally delivered ngf affects ocular dominance column formation or the plasticity produced by monocular deprivation in cats at the height of the critical period, we infused r ... | 2001 | 11738495 |
| relationships of local inhibitory and excitatory circuits to orientation preference maps in ferret visual cortex. | the contribution and precise role of intracortical circuits in generating orientation tuned responses in visual cortical neurons is still controversial. to address this question, the relationship between excitatory and inhibitory synaptic connections and orientation maps in ferret striate cortex was investigated by combining in vivo optical imaging and in vitro scanning laser photostimulation. excitatory and inhibitory inputs to pyramidal cells originated preferentially from regions with similar ... | 2002 | 11739266 |
| comparative analysis of aortic impedance and wave reflection in ferrets and dogs. | our modified version of the t-tube arterial model (consisting of two parallel, loss-free transmission paths terminating in lumped loads of complex and frequency-dependent nature) was applied to experimental measurements of ascending aortic pressure and of ascending and descending aortic flows taken from dogs and ferrets. our aim was to provide quantitative evaluation of the aortic pressure and flow pulse wave components as they relate to the distribution of arterial properties and relate to wave ... | 2002 | 11748069 |
| susceptibility of the siberian polecat to subcutaneous and oral yersinia pestis exposure. | to determine if the siberian polecat (mustela eversmannii) represents a suitable model for the study of plague pathogenesis and prevention in the black-footed ferret (mustela nigripes), polecats were exposed to 10(3), 10(7), or 10(10) yersinia pestis organisms by subcutaneous injection; an additional group was exposed to y. pestis via ingestion of a plague-killed mouse. plague killed 88% of polecats exposed to y. pestis (71% mortality in the 10(3) group, 100% mortality in the 10(7) and 10(10) gr ... | 2001 | 11763738 |
| bmp-7 gene transfer to inflamed ferret dental pulps. | in vivo and ex vivo gene transfer are being developed for localized skeletal regeneration. these strategies for tissue regeneration were tested in an adult ferret model of vital pulp therapy. in this model a reversible pulpitis was induced first. then after 3 d, the pulps were directly infected with recombinant virus or implanted with ex vivo transduced autologous dermal fibroblasts. the genome of the recombinant adenovirus contained a full-length cdna encoding mouse bone morphogenetic protein ( ... | 2001 | 11767280 |
| linkage of reproductive sciences: from 'quick fix' to 'integrated' conservation. | our laboratory has experienced four phases in understanding how the reproductive sciences contribute to genuine conservation of biodiversity. the first is the 'quick fix phase' in which the erroneous assumption is made that extant knowledge and techniques are readily adaptable to an unstudied wild animal to produce offspring rapidly. the second is the 'species-specificity phase' in which it is recognized that every species has evolved unique reproductive mechanisms that must be mastered before p ... | 2001 | 11787164 |
| long-chain polyunsaturated fatty acids (lc-pufa) during early development: contribution of milk lc-pufa to accretion rates varies among organs. | long-chain polyunsaturated fatty acids (lc-pufa) accretion (essential for growth and neural development) was studied from late fetal throughout weaning age in the ferret, a species with maternal lc-pufa sufficiency during pregnancy and lactation. the data show that a) accretion rate of lc-pufa is rapid during early postnatal development, b) milk lc-pufa decrease during lactation, c) adipose tissue lc-pufa level is directly related to milk lc-pufa level, while accretion in brain and liver exceeds ... | 2001 | 11787708 |
| the ultrastructure of the intra-articular disc of the temporomandibular joint, with special reference to fibrocartilage. | cells in the intra-articular disc of the temporomandibular joint of the rat, guinea pig, rabbit, ferret, marmoset and sheep were studied at the ultrastructural level. the cells were generally rounded in outline and possessed moderate amounts of roughened endoplasmic reticulum and other organelles associated with protein synthesis and secretion. no intracellular collagen profiles were observed. many of the cells possessed conspicuous amounts of microfilamentous material. cell membranes in the rat ... | 1999 | 11799762 |
| comparison of the affinity of beta-blockers for two states of the beta 1-adrenoceptor in ferret ventricular myocardium. | we compared the potency of 11 clinically available beta-blockers as antagonists of the positive inotropic effects of (-)-isoprenaline and cgp12177 on ferret ventricular myocardium. (-)-cgp12177, (-)-pindolol and (-)-alprenolol were non-conventional partial agonists with intrinsic activity of 0.7, 0.2 and 0.1 respectively. all beta-blockers antagonized in a concentration-dependent and surmountable manner the positive inotropic effects of both (-)-isoprenaline and cgp12177. the potency of each bet ... | 2002 | 11815381 |
| successful production of offspring after superovulation and in vitro culture of embryos from domestic ferrets (mustela putorius furos). | in an effort to expand the use of ferrets as models for genetic disease, several experimental parameters that are required for successful genetic manipulation in this species were investigated. optimum superovulation (19.3 +/- 0.6 oocytes and embryos per female) was achieved after injections of 100 iu equine chorionic gonadotrophin (ecg) and 150 iu human chorionic gonadotrophin (hcg). the ovulation rate achieved by the treatment was more than double that induced by mating. mating with a male imm ... | 2001 | 11818023 |
| development of cortical circuits: lessons from ocular dominance columns. | the development of ocular dominance columns has served as a rosetta stone for understanding the mechanisms that guide the construction of cortical circuits. traditionally, the emergence of ocular dominance columns was thought to be closely tied to the critical period, during which columnar architecture is highly susceptible to alterations in visual input. however, recent findings in cats, monkeys and ferrets indicate that columns develop far earlier, more rapidly and with considerably greater pr ... | 2002 | 11823803 |
| development of cholinergic amacrine cell stratification in the ferret retina and the effects of early excitotoxic ablation. | the present study has examined the emergence of cholinergic stratification within the developing inner plexiform layer (ipl), and the effect of ablating the cholinergic amacrine cells on the formation of other stratifications within the ipl. the population of cholinergic amacrine cells in the ferret's retina was identified as early as the day of birth, but their processes did not form discrete strata until the end of the first postnatal week. as development proceeded over the next five postnatal ... | 2001 | 11829302 |
| effect of denervation on healing after tooth replantation in the ferret. | studies have shown that the sensory nerves participate in inflammation and immune responses and possess trophic-facilitating wound healing in general. tooth avulsion represents a pulpal and periodontal injury, and the mechanisms involved in the healing responses subsequent to replantation of teeth are still unclear. the objective of this study was to investigate the healing responses after denervation and replantation of teeth. unilateral denervation was performed in 15 ferrets by axotomy of the ... | 2001 | 11831488 |
| macroscopic and roentgenographic anatomy of the skull of the ferret (mustela putorius furo). | normal macroscopic and roentgenographic features of the skull of the ferret (mustela putorius furo) were examined and described. data were based on a sample of 100 (50 male and 50 female) adult ferrets of known body weight and age. the skull was described macroscopically according to six standard views, i.e. dorsal, lateral, ventral, caudal, cranial and midsagittal. the mandible was described separately. the roentgenographic characteristics of the ferret skull were demonstrated only in lateral a ... | 2002 | 11831741 |
| representation of sound source direction in the superior colliculus of the guinea pig in a virtual auditory environment. | the deep layers of the superior colliculus (sc) receive visual, auditory, and somatosensory input. a major function of the sc is the control of orientation movements of the eye, head, and pinna. while a topographical map for sound source direction remains elusive in primary auditory structures of mammals, such a map for azimuthal sound source directions has been reported in the deep layers of the sc. moreover, a gradient of elevation tuning has been also seen in the sc of ferrets and cats. here ... | 2002 | 11845252 |
| sexually dimorphic activation of galanin neurones in the ferret's dorsomedial preoptic area/anterior hypothalamus after mating. | male ferrets in breeding condition possess three times as many galanin-immunoreactive (ir) neurones as oestrous females in the sexually dimorphic dorsomedial preoptic area/anterior hypothalamus (dmpoa/ah). using fos-ir as a marker of activation, we investigated whether mating with intromission differentially activates this sexually dimorphic group of galanin-ir neurones in male and female ferrets. male ferrets that intromitted had a significantly greater percentage of galanin-ir neurones in the ... | 2002 | 11849371 |
| developmental regulation of brain nitric oxide synthase expression in the ferret thalamic reticular nucleus. | we have found that cells in the ferret thalamic reticular nucleus (trn) express brain nitric oxide synthase (bnos) in a transient pattern during early postnatal development. similar to our previous findings in the lateral geniculate nucleus (lgn), bnos expression in the trn is first observed at postnatal day 7 (p7) and continues to p35. quantitative measures show a significant change in the relative numbers of bnos+ cells from p7-p35, and suggest there is a transition in morphology from a bipola ... | 2002 | 11852184 |
| ferret orthopedics. | orthopedic conditions requiring surgical intervention and correction frequently occur in the ferret patient. elbow luxations and long bone fractures are among the most common syndromes affecting the ferret patient, which often presents in an emergency setting. orthopedic conditions in the ferret, as in other mammalian species, are often the result of trauma. surgical treatment including reduction and stabilization of the affected bony structure, combined with supervision and the recommended post ... | 2002 | 11862826 |
| ferrets as a model system for renal disease secondary to intestinal infection with escherichia coli o157:h7 and other shiga toxin-producing e. coli. | ferrets were evaluated as a possible small animal model for the development of colitis and/or signs of the hemolytic uremic syndrome after oral infection with escherichia coli o157:h7 or other shiga toxin--producing e. coli (stec). ferrets treated with streptomycin (stm) had higher counts of e. coli o157:h7 strain 86-24 stm-resistant (stm(r)) or o91:h21 strain b2f1 stm(r) in their stools than non--stm-treated animals. none of the animals displayed evidence of colitis, but stm-treated animals fed ... | 2002 | 11865409 |
| architecture and callosal connections of visual areas 17, 18, 19 and 21 in the ferret (mustela putorius). | visual areas 17, 18, 19 and 21 of the ferret can be distinguished on the grounds of cytoarchitecture, myeloarchitecture and cytochrome oxidase reactivity, and with transneuronal tract-tracing from the eye. each visual area contains callosally connected, as well as acallosal, regions. the callosal connections originate mainly from layers 2 and 3 and, more widely, from layer 6. callosally projecting neurons and callosal terminals are organized in three roughly medio-laterally oriented bands. the p ... | 2002 | 11884356 |
| the representation of the visual field in three extrastriate areas of the ferret (mustela putorius) and the relationship of retinotopy and field boundaries to callosal connectivity. | we describe representations of the visual field in areas 18, 19 and 21 of the ferret using standard microelectrode mapping techniques. in all areas the azimuths are represented as islands of peripheral visual field surrounded by central visual field representation. the zero meridian was found at the 17/18 and 19/21 borders; at the 18/19 and anterior border of 21 the relative periphery of the visual field was found. in areas 18 and 19, elevations are represented in a smooth medio-lateral progress ... | 2002 | 11884357 |
| oral administration of cyclopentane neuraminidase inhibitors protects ferrets against influenza virus infection. | several cyclopentane inhibitors of influenza virus neuraminidase that have inhibitory activities in tissue culture similar to those of zanamivir and oseltamivir have recently been described. these new inhibitors have been examined for efficacy against a virulent h3n2 influenza virus when administered orally to infected ferrets. preliminary studies indicated that oral administration of bcx-1923, bcx-1827, or bcx-1812 (rwj-270201) at a dose of 5 or 25 mg/kg of body weight was active in ferrets in ... | 2002 | 11897581 |
| heterogeneous expression of kchip2 isoforms in the ferret heart. | kv4 channels are believed to underlie the rapidly recovering cardiac transient outward current (i(to)) phenotype. however, heterologously expressed kv4 channels fail to fully reconstitute the native current. kv channel interacting proteins (kchips) have been shown to modulate kv4 channel function. to determine the potential involvement of kchips in the rapidly recovering i(to), we cloned three kchip2 isoforms (designated fkchip2, 2a and 2b) from the ferret heart. based upon immunoblot data sugge ... | 2002 | 11897837 |
| acetaminophen udp-glucuronosyltransferase in ferrets: species and gender differences, and sequence analysis of ferret ugt1a6. | the principal objective of this study was to determine whether ferrets glucuronidate acetaminophen more slowly compared with other species, and if so investigate the molecular basis for the difference. acetaminophen-udp-glucuronosyltransferase (ugt) activities were measured using hepatic microsomes from eight ferrets, four humans, four cats, four dogs, rat, mouse, cow, horse, monkey, pig and rabbit. gender differences between male and female ferret livers were explored using enzyme kinetic analy ... | 2001 | 11903872 |
| the effect of low and high doses of beta-carotene and exposure to cigarette smoke on the lungs of ferrets. | when the diets of ferrets were supplemented with large (pharmacologic) daily doses of beta-carotene (bc) for 6 months, the levels of retinoic acid and the retinoic acid receptor beta declined significantly in lung tissues. indicators of cell proliferation (c-jun and c-fos proteins and others) increased. histologic observations showed that feeding high doses of bc resulted in keratinized squamous metaplasia in the lung tissues. when high-doses of bc were combined with daily exposure to cigarette ... | 2002 | 11908745 |
| traumatic rupture of the ureter: 10 cases. | a retrospective study was performed on eight dogs, one cat, and one ferret with ruptured ureters secondary to blunt trauma. the most common physical examination findings were abdominal distension/discomfort (in five of 10 animals) and gross hematuria (in five of six animals). multiple organ injury was also common (in seven of 10 animals). loss of retroperitoneal and peritoneal detail was the most common radiographic finding (in four of six animals). ureteronephrectomy was the most common surgica ... | 2002 | 11908838 |
| acute ataxia in a young ferret following canine distemper vaccination. renal failure after epinephrine overdose. | 2001 | 11910412 | |
| pharmacological aspects of ipecac syrup (tjn-119)-induced emesis in ferrets. | in order to elucidate the precise mechanism of ipecac syrup (tjn-119) on the occurrence of vomiting, we examined the effects of ipecac syrup on the abdominal afferent nerve activity as well as on the 5-ht levels of the ileum and area postrema in ferrets. oral administration of tjn-119 (0.5 mg/kg) produced a significant increase in afferent abdominal vagus nerve activity which lasted approximately 1 hour. the maximum response induced by tjn-119 was estimated to be 219 +/- 18% of the pre-injection ... | 2000 | 11913711 |
| role of retinal afferents in regulating growth and shape of the lateral geniculate nucleus. | segregated binocular maps in the dorsal lateral geniculate nucleus (lgn) develop from a stage where they initially overlap. sophisticated computational models have been used to describe the dynamics of three-dimensional lgn shape changes that play a role in segregation. these models have revealed specific nuclear growth vectors associated with the process of ocular segregation in the lgn (williams and jeffery [2001] j comp neurol 430:332-342.). in this study, we use similar techniques to determi ... | 2002 | 11920706 |
| reelin immunoreactivity in the adult neocortex: a comparative study in rodents, carnivores, and non-human primates. | recent evidence indicates that, in addition to playing a crucial role in early cortical development, intercellular signaling mediated by the protein reelin may be widely active in the adult neocortex. the extent of reelin distribution and its functional role in the adult are not clear yet. here, we have examined reelin immunoreactivity in the neocortex of an adult rodent (rat, rattus norvegicus), a carnivore (ferret, mustela putorius), and a primate (macaque monkeys macaca nemestrina, macaca mul ... | 2002 | 11923015 |
| disruption of transient photoreceptor targeting within the inner plexiform layer following early ablation of cholinergic amacrine cells in the ferret. | photoreceptors in the ferret's retina have been shown to project transiently to the inner plexiform layer (ipl) prior to their differentiation of an outer segment. on postnatal day 15 (p-15), when this projection achieves maximal density, the photoreceptors projecting into the ipl extend primarily to one of two depths, coincident with the processes of cholinergic amacrine cells. the present study has used an excitotoxic approach employing subcutaneous injections of l-glutamate to ablate these ch ... | 2001 | 11925009 |