Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| call type signals caller goal: a new take on ultimate and proximate influences in vocal production. | after 40 years of debate it remains unclear whether signallers produce vocalizations in order to provide receivers with information about call context or external stimuli. this has led some researchers to propose that call production is arousal- or affect-based. although arousal influences certain acoustic parameters within a call type, we argue that it cannot explain why individuals across vertebrates produce different call types. given emerging evidence that calls are goal-based, we argue that ... | 2018 | 29896860 |
| effect of genetic background and delivery route on the preclinical properties of a live attenuated rsv vaccine. | a safe and effective vaccine against rsv remains an important unmet public health need. intranasally (in) delivered live-attenuated vaccines represent the most extensively studied approach for immunization of rsv-naïve infants and children, however, achieving an effective balance of attenuation and immunogenicity has proven challenging. here we report pre-clinical immunogenicity and efficacy data utilizing a live-attenuated vaccine candidate, rgδm2-2, which was obtained by deleting the m2-2 open ... | 2018 | 29920563 |
| synthesis and molecular modelling studies of pyrimidinones and pyrrolo[3,4-d]-pyrimidinodiones as new antiplasmodial compounds. | background malaria is responsible for 429,000 deaths per year worldwide, and more than 200 million cases were reported in 2015. increasing parasite resistance has imposed restrictions to the currently available antimalarial drugs. thus, the search for new, effective and safe antimalarial drugs is crucial. heterocyclic compounds, such as dihydropyrimidinones (dhpm), synthesised via the biginelli multicomponent reaction, as well as bicyclic compounds synthesised from dhpms, have emerged as potenti ... | 2018 | 29924131 |
| recurrent loss of apobec3h activity during primate evolution. | genes in the apobec3 family encode cytidine deaminases that provide a barrier against viral infection and retrotransposition. of all the apobec3 genes in humans, apobec3h (a3h) is the most polymorphic: some genes encode stable and active a3h proteins, while others are unstable and poorly antiviral. such variation in human a3h affects interactions with the lentiviral antagonist vif, which counteracts a3h via proteasomal degradation. in order to broaden our understanding of a3h-vif interactions, a ... | 2018 | 29925657 |
| antibacterial interactions, anti-inflammatory and cytotoxic effects of four medicinal plant species. | the constant emergence of antibiotic resistant species and the adverse side effects of synthetic drugs are threatening the efficacy of the drugs that are currently in use. this study was aimed at investigating the possible antibacterial interactions, anti-inflammatory and cytotoxic effects of selected medicinal plants based on their traditional usage. | 2018 | 29970064 |
| population genetic structure and evolutionary history of bale monkeys (chlorocebus djamdjamensis) in the southern ethiopian highlands. | species with a restricted geographic distribution, and highly specialized habitat and dietary requirements, are particularly vulnerable to extinction. the bale monkey (chlorocebus djamdjamensis) is a little-known arboreal, bamboo-specialist primate endemic to the southern ethiopian highlands. while most bale monkeys inhabit montane forests dominated by bamboo, some occupy forest fragments where bamboo is much less abundant. we used mitochondrial dna (mtdna) sequences to analyse the genetic struc ... | 2018 | 29986642 |
| systemic dpp4 activity is reduced during primary hiv-1 infection and is associated with intestinal rorc+ cd4+ cell levels: a surrogate marker candidate of hiv-induced intestinal damage. | combined anti-retroviral therapy (cart) transformed hiv-1 from a deadly disease into a chronic infection, but does not cure hiv infection. it also does not fully restore hiv-induced gut damage unless administered extremely early after infection. additional biomarkers are needed to evaluate the capacity of therapies aimed at hiv remission/cure to restore hiv-induced intestinal immune damage and limit chronic inflammation. herein, we aimed to identify a systemic surrogate marker whose levels would ... | 2018 | 29987877 |
| application of tetracycline hydrochloride loaded-fungal chitosan and aloe vera extract based composite sponges for wound dressing. | chitosan composite material has been used as an efficient drug carrier for potential drug delivery systems in specific cases of wound dressing management. in the present study, 0.5 g/l of the antibiotic tetracycline hydrochloride (tch) was loaded into 1% fungal chitosan (fcs) incorporated with 0.2% of aloe vera extract (ave). two types of sponges were prepared, with and without ave, such as fcs-ave-tch and fcs-tch, respectively. they were characterized by uv-visible spectrophotometer, attenuated ... | 2018 | 29988799 |
| hepatic vitamin a concentrations in vervets (chlorocebus aethiops) supplemented with carotenoids derived from oil palm. | commonly used in biomedical research, vervets (chlorocebus aethiops) are omnivorous but primarily meet their vitamin a requirements from provitamin a carotenoids. hypervitaminosis a has occurred in vervets that consume feed high in preformed vitamin a. we investigated the vitamin a status of vervets supplemented daily with various antioxidants derived from palm oil. male vervets (n = 40) were placed for 23 wk on a high-fat diet (34.9% energy) containing 645 μ g retinol activity equivalents (rae) ... | 2018 | 30021671 |
| fluorenyl-loaded quatsome nanostructured fluorescent probes. | delivery of hydrophobic materials in biological systems, for example, contrast agents or drugs, is an obdurate challenge, severely restricting the use of materials with otherwise advantageous properties. the synthesis and characterization of a highly stable and water-soluble nanovesicle, referred to as a quatsome (qs, vesicle prepared from cholesterol and amphiphilic quaternary amines), that allowed the nanostructuration of a nonwater soluble fluorene-based probe are reported. photophysical prop ... | 2017 | 30023713 |
| bovine herpesvirus 1 entry by a low-ph endosomal pathway. | bovine herpesvirus 1 (bohv-1) is an alphaherpesvirus that poses a significant challenge to health and welfare in the cattle industry. we investigated the cellular entry route utilized by bohv-1. we report that bohv-1 enters madin darby bovine kidney (mdbk) cells, bovine turbinate cells, and african green monkey kidney (vero) cells via a low-ph-mediated endocytosis pathway. treatment of mdbk cells with hypertonic medium, which inhibits receptor-mediated endocytosis, prevented infection as measure ... | 2018 | 30045989 |
| modeling of fusion inhibitor treatment of rsv in african green monkeys. | respiratory syncytial virus (rsv) is a respiratory infection that can cause serious illness, particularly in infants. in this study, we test four different model implementations for the effect of a fusion inhibitor, including one model that combines different drug effects, by fitting the models to data from a study of tmc353121 in african green monkeys. we use mathematical modeling to estimate the drug efficacy parameters, εmax, the maximum efficacy of the drug, and ec50, the drug concentration ... | 2018 | 30048719 |
| greater microbial translocation and vulnerability to metabolic disease in healthy aged female monkeys. | monkeys demonstrate gastrointestinal barrier dysfunction (leaky gut) as evidenced by higher biomarkers of microbial translocation (mt) and inflammation with ageing despite equivalent health status, and lifelong diet and environmental conditions. we evaluated colonic structural, microbiomic and functional changes in old female vervet monkeys (chlorocebus aethiops sabeus) and how age-related leaky gut alters responses to western diet. we additionally assessed serum bovine immunoglobulin therapy to ... | 2018 | 30054517 |
| tandem 3' utr patterns and gene expression profiles of marc-145 cells during prrsv infection. | porcine reproductive and respiratory syndrome virus (prrsv) causes substantial economic losses to the global pig industry. alternative polyadenylation (apa) is a mechanism that diversifies gene expression, which is important for tumorigenesis, development, and cell differentiation. however, it is unclear whether apa plays a role in the course of prrsv infection. to address this issue, in this study we carried out a whole-genome transcriptome analysis of prrsv-infected marc-145 african green monk ... | 2018 | 30069823 |
| a quantitative assessment of dynamical differences of rsv infections in vitro and in vivo. | experimental results in vitro and in animal models are used to guide researchers in testing vaccines or treatment in humans. however, viral kinetics are different in vitro, in animals, and in humans, so it is sometimes difficult to translate results from one system to another. in this study, we use a mathematical model to fit experimental data from multiple cycle respiratory syncytial virus (rsv) infections in vitro, in african green monkey (agm), and in humans in order to quantitatively compare ... | 2018 | 30144786 |
| longer β oscillatory episodes reliably identify pathological subthalamic activity in parkinsonism. | the efficacy of deep brain stimulation (dbs) - primarily of the subthalamic nucleus (stn) - for advanced parkinson's disease (pd) is commonly attributed to the suppression of pathological synchronous β oscillations along the cortico-thalamo-basal ganglia network. conventional continuous high-frequency dbs indiscriminately influences pathological and normal neural activity. the dbs protocol would therefore be more effective if stimulation was only applied when necessary (closed-loop adaptive dbs) ... | 2018 | 30145811 |
| effects of decavanadate salts with organic and inorganic cations on escherichia coli, giardia intestinalis, and vero cells. | decavanadate salts with nicotinamide (3-pyridinecarboxamide, 3-pca) and isonicotinamide (4-pyridinecarboxamide, 4-pca) in both neutral and protonated forms, (3-hpca)4[h2v10o28]·2h2o·2(3-pca) (complex i) and (4-hpca)4[h2v10o28]·2(4-pca) (complex ii), have been synthesized and characterized by vibrational spectroscopy (infrared and raman), thermogravimetric analysis (tga), 51v nmr, and single-crystal x-ray diffraction analysis. the effects of sodium decavanadate (henceforth called nav10) and compo ... | 2018 | 30198266 |
| rapid quantification of vesicular stomatitis virus in vero cells using laser force cytology. | the ability to rapidly and accurately determine viral infectivity can help improve the speed of vaccine product development and manufacturing. current methods to determine infectious viral titers, such as the end-point dilution (50% tissue culture infective dose, tcid50) and plaque assays are slow, labor intensive, and often subjective. in order to accelerate virus quantification, laser force cytology (lfc) was used to monitor vesicular stomatitis virus (vsv) infection in vero (african green mon ... | 2018 | 30219365 |
| thiazoles with cyclopropyl fragment as antifungal, anticonvulsant, and anti-toxoplasma gondii agents: synthesis, toxicity evaluation, and molecular docking study. | synthesis and investigation of antifungal, anticonvulsant and anti-toxoplasma gondii activities of ten novel (2-(cyclopropylmethylidene)hydrazinyl)thiazole 3a-3j are presented. among the derivatives, compounds 3a-3d and 3f-3j possess very high activity against candida spp. atcc with mic = 0.015-7.81 µg/ml. compounds 3a-3d and 3f-3j possess also very high activity towards most of strains of candida spp. isolated from clinical materials with mic = 0.015-7.81 µg/ml. the activity of these compounds ... | 2018 | 30220831 |
| an azine-based carbothioamide chemosensor for selective and sensitive turn-on-off sequential detection of zn(ii) and h2po4-, live cell imaging and inhibit logic gate. | hydrazino-carbothioamide, 1, serves as a turn-on fluorescent chemosensor to zn2+ and the mixture shows green emission (λem 492) in presence of large number of ions with impressive limit of detection (lod), 0.59 nm. intense fluorescence of zn-complex is selectively turn-off upon adding h2po4- only to the limit of detection, 26 μm, while other anions remain silent. the sensing mechanism of 1 is established by suppressing the esipt of 1 and complexation with zn2+ (chef) is supported by job's plot, ... | 2019 | 30227347 |
| schistosoma mansoni infection in human and nonhuman primates in selected areas of oromia regional state, ethiopia. | the transmission of schistosomiasis, caused by trematodes of the genus schistosoma, relies on freshwater snails that act as an intermediate host while human and other mammalian act as the definitive hosts. many non-human primates (nhps) such as chlorocebus aethiops (vervet) and papio anubis (baboon) are reported to be infected with schistosoma mansoni in ethiopia, but the role they play in parasite maintenance and transmission is still not clear. the objective of this study was, therefore, to de ... | 2019 | 30280709 |
| low-ph endocytic entry of the porcine alphaherpesvirus pseudorabies virus. | the alphaherpesvirus pseudorabies virus (prv) is the causative agent of pseudorabies, a disease of great economic and welfare importance in swine. other alphaherpesviruses, including herpes simplex virus (hsv), utilize low-ph-mediated endocytosis to enter a subset of cell types. we investigated whether prv used this entry pathway in multiple laboratory model cell lines. inhibition of receptor-mediated endocytosis by treatment with hypertonic medium prevented prv entry. prv entry into several cel ... | 2019 | 30355685 |
| characterization of glucose-stimulated insulin release protocols in african green monkeys (chlorocebus aethiops). | management of diabetes remains a major health and economic challenge, demanding test systems in which to develop new therapies. these studies assessed different methodologies for determining glucose tolerance in green monkeys. | 2019 | 30357856 |
| synthesis, docking, admet prediction, cytotoxicity and antimicrobial activity of oxathiadiazole derivatives. | a series of molecules bearing oxathiadiazole, a five membered heterocyclic ring has been designed, synthesized and screened for antimicrobial activity. molecules, 1a, 1b, 1d, 3a-b and 4a-b were found to be highly active (mic value upto 1.5 μg/ml) against different human pathogens, namely s. aureus, b. cerus, p. aeruginosa and e. coli. some of the compounds, 1a, 1b and 1d have also shown the antifungal activity (mic value upto 6.2 μg/ml) against candida albicans, candida glubrate and candida crus ... | 2018 | 30366286 |
| designing heparan sulfate-based biocompatible polymers and their application for intracellular stimuli-sensitive drug delivery. | heparan sulfate (hs) is a kind of natural polysaccharides with good biocompatibility. and as drug carriers, it has some advantages compared to heparin. however, the preparation of hs is cumbersome and difficult, which limits its application in drug delivery. here, we use modern separation technique combined with chromatography to establish a new preparation method of hs. the molecular weight and degree of dispersion of hs were (1.03 × 104 ± 107) kda and 1.106, respectively. hs also showed low an ... | 2019 | 30423731 |
| croton gratissimus leaf extracts inhibit cancer cell growth by inducing caspase 3/7 activation with additional anti-inflammatory and antioxidant activities. | croton species (euphorbiaceae) are distributed in different parts of the world, and are used in traditional medicine to treat various ailments including cancer, inflammation, parasitic infections and oxidative stress related diseases. the present study aimed to evaluate the antioxidant, anti-inflammatory and cytotoxic properties of different extracts from three croton species. | 2018 | 30428879 |
| aerosol exposure to intermediate size nipah virus particles induces neurological disease in african green monkeys. | nipah virus (niv) infection can lead to severe respiratory or neurological disease in humans. transmission of niv has been shown to occur through contact with virus contaminated fomites or consumption of contaminated food. previous results using the african green monkey (agm) model of niv infection identified aspects of infection that, while similar to humans, don't fully recapitulate disease. previous studies also demonstrate near uniform lethality that is not consistent with human niv infectio ... | 2018 | 30462637 |
| a nonhuman primate model of early alzheimer's disease pathologic change: implications for disease pathogenesis. | nonhuman primates may serve as excellent models of sporadic age-associated brain β-amyloid deposition and alzheimer's disease pathologic changes. we examined whether a vervet nonhuman primate model recapitulated pathologic, physiologic, and behavioral features of early alzheimer's disease. | 2019 | 30467082 |
| in vitro anticancer, anti-inflammatory, and antioxidant potentials of ephedra aphylla. | the goal of our study is to test whether a naturally occurring plant, ephedra aphylla, will show antiproliferative ability against tested cell lines and to test its anti-inflammatory and antioxidative potentials. | 2019 | 30488855 |
| in vitro analysis of synthetic peptides in blocking the entry of dengue virus. | dengue fever is the most prevalent arthropod-borne viral disease, and no specific therapeutic or promising antiviral drug is available for its treatment. peptide inhibitors are less toxic than synthetic compounds and have found proven effective against viral infections. here, three peptides that mimic part of the e protein of the dengue virus (denv) were synthesized and evaluated for their inhibitory activity against four serotypes of denv in african green monkey kidney (vero) and rhesus macaque ... | 2019 | 30508603 |
| cytotoxic and genotoxic effects of fluconazole on african green monkey kidney (vero) cell line. | fluconazole is a broad-spectrum triazole antifungal that is well-established as the first-line treatment for candida albicans infections. despite its extensive use, reports on its genotoxic/mutagenic effects are controversial; therefore, further studies are needed to better clarify such effects. african green monkey kidney (vero) cells were exposed in vitro to different concentrations of fluconazole and were then evaluated for different parameters, such as cytotoxicity (mtt/cell death by fluores ... | 2018 | 30515410 |
| [evaluation of the reproductive potential of encephalitozoon intestinalis in four different cell line]. | microsporidia are parasites that can cause infections in many vertebrate and invertebrate organisms and produce small spores resistant to environmental conditions. as they are obligate intracellular parasites, axenic cultures cannot be performed. the aim of this study was to investigate the reproductive potential of the parasite in human colon epidermal adenocarcinoma (caco-2), human monocytic (u937), african green monkey renal epithelial (vero) and human kidney epithelial (hek-293) cell lines o ... | 2018 | 30522424 |
| bio-guided search of active indole alkaloids from tabernaemontana catharinensis: antitumour activity, toxicity in silico and molecular modelling studies. | active plant metabolites have been used as prototype drugs. in this context, tabernaemontana catharinensis (apocynaceae) has been highlighted because of the presence of active indole alkaloids. thus, this study aims the bio-guided search of t. catharinensis cytotoxic alkaloids. the chemical composition was identified by high-resolution mass spectrometry, and fractionation was performed by open column and preparative thin-layer chromatography, from plant stems. the enriched fractions were tested ... | 2019 | 30599414 |
| natural variation in fetal cortisol exposure is associated with neonatal body mass in captive vervet monkeys (chlorocebus aethiops). | poor maternal condition during gestation is commonly associated with impaired fetal growth in humans and other animals. although elevated maternal glucocorticoids (gcs) are often implicated as the mechanism of intrauterine growth stunting, the direct contribution of maternal gcs remains unclear because enzymatic conversion of gcs at the placenta may limit the ability of maternal hormones to reach the fetus. further, because previous studies on gestational stress have often employed synthetic gcs ... | 2019 | 30604879 |
| decreased antibiotic susceptibility driven by global remodeling of the klebsiella pneumoniae proteome. | bacteria can circumvent the effect of antibiotics by transitioning to a poorly understood physiological state that does not involve conventional genetic elements of resistance. here we examine antibiotic susceptibility with a class a β-lactamase+ invasive strain of klebsiella pneumoniae that was isolated from a lethal outbreak within laboratory colonies of chlorocebus aethiops sabaeus monkeys. bacterial responses to the ribosomal synthesis inhibitors streptomycin and doxycycline resulted in dist ... | 2019 | 30617156 |
| microrna-146a-5p association with the cardiometabolic disease risk factor tmao. | trimethylamine-n-oxide (tmao), a microbial choline metabolism byproduct that is processed in the liver and excreted into circulation, is associated with increased atherosclerotic lesion formation and cardiovascular disease risk. genetic regulators of tmao levels are largely unknown. in the present study, we used 288 mice from a genetically heterogeneous mouse population [diversity outbred (do)] to determine hepatic microrna associations with tmao in the context of an atherogenic diet. we also va ... | 2019 | 30633643 |
| fluorescein derived schiff base as fluorimetric zinc (ii) sensor via 'turn on' response and its application in live cell imaging. | a novel schiff base l composed of fluorescein hydrazine and a phenol functionalized moiety has been designed and prepared via cost-effective condensation reaction. the l is utilized for selective sensing of zn2+ over other environmental and biological relevant metal ions in aqueous alcoholic solution under physiological ph range. the binding of zn2+ to the receptor l is found to causes ~23 fold fluorescence enhancement of l. the 1:1 binding mode of the metal complex is established by combined uv ... | 2019 | 30641362 |
| erk-independent african green monkey pluripotent stem cells in a putative chimera-competent state. | generating human organs inside interspecies chimeras might one day produce patient-specific organs for clinical applications, but further advances in identifying human chimera-competent pluripotent stem (ps) cells are needed. moreover, the potential for human ps cells to contribute to the brains in human-animal chimeras raises ethical questions. the use of non-human primate (nhp) chimera-competent ps cells would allow one to test interspecies organogenesis strategies while also bypassing such et ... | 2019 | 30660369 |
| nonketotic hyperglycinemia in captive-bred vervet monkeys (chlorocebus aethiops) with cataracts. | nonketotic hyperglycinemia (nkh) is a rare metabolic disorder that is characterized by high levels of glycine in plasma and cerebrospinal fluid in humans. in this study, total congenital cataract captive-bred vervet monkeys (chlorocebus aethiops) that are hyperglycinemic were screened to identify mutations in bola type 3 (bola3), glutaredoxin 5 (glrx5), and lipoate synthase (lias) genes. | 2019 | 30724368 |
| triterpene derivatives as relevant scaffold for new antibiofilm drugs. | new medicines for the treatment of bacterial biofilm formation are required. for thisreason, this study shows the in vitro activity of betulinic acid (ba), ursolic acid (ua) and their twentyderivatives against planktonic and biofilm cells (gram-positive bacterial pathogens: enterococcusfaecalis, <i>staphylococcus aureus</i> and <i>staphylococcus epidermidis</i>). we evaluated the antibiofilm activity(through the crystal violet method), as well as the antibacterial activity via absorbance (od<sub ... | 2019 | 30754716 |
| the responses of lungs and adjacent lymph nodes in responding to yersinia pestis infection: a transcriptomic study using a non-human primate model. | initiation of treatment during the pre-symptomatic phase of yersinia pestis (y. pestis) infection is particularly critical. the rapid proliferation of y. pestis typically couples with the manifestation of common flu-like early symptoms that often misguides the medical intervention. our study used african green monkeys (agm) that did not exhibit clear clinical symptoms for nearly two days after intranasal challenge with y. pestis and succumbed within a day after showing the first signs of clinica ... | 2019 | 30789917 |
| biomolecular interaction, anti-cancer and anti-angiogenic properties of cobalt(iii) schiff base complexes. | two cobalt(iii) schiff base complexes, trans-[co(salen)(da)2](clo4) (1) and trans-[co(salophen)(da)2](clo4) (2) (where salen: n,n'-bis(salicylidene)ethylenediamine, salopen: n,n'-bis(salicylidene)-1,2-phenylenediamine, da: dodecylamine) were synthesised and characterised using various spectroscopic and analytical techniques. the binding affinity of both the complexes with ct-dna was explored adopting uv-visible, fluorescence, circular dichroism spectroscopy and cyclic voltammetry techniques. the ... | 2019 | 30804454 |
| signature microrna expression profile is associated with lipid metabolism in african green monkey. | non-human primates (nhps) are important models of medical research on obesity and cardiovascular diseases. as two of the most commonly used nhps, cynomolgus macaque (cm) and african green monkey (agm) own different capacities in lipid metabolism of which the mechanism is unknown. this study investigated the expression profiles of lipid metabolism-related micrornas (mirnas) in cm and agm and their possible roles in controlling lipid metabolism-related gene expression. | 2019 | 30819205 |
| metabolomic analyses reveal lipid abnormalities and hepatic dysfunction in non-human primate model for yersinia pestis. | pneumonic plague is caused by the aerosolized form of yersinia pestis and is a highly virulent infection with complex clinical consequences, and without treatment, the fatality rate approaches 100%. the exact mechanisms of disease progression are unclear, with limited work done using metabolite profiling to study disease progression. | 2018 | 30830480 |
| modified mhc class ii-associated invariant chain induces increased antibody responses against plasmodium falciparum antigens after adenoviral vaccination. | adenoviral vectors can induce t and b cell immune responses to ags encoded in the recombinant vector. the mhc class ii invariant chain (ii) has been used as an adjuvant to enhance t cell responses to tethered ag encoded in adenoviral vectors. in this study, we modified the ii adjuvant by insertion of a furin recognition site (ii-fur) to obtain a secreted version of the ii. to test the capacity of this adjuvant to enhance immune responses, we recombined vectors to encode plasmodium falciparum vir ... | 2019 | 30833346 |
| effects of storage in recovery media on sublethally heated polio and echo viruses. | in vitro renaturation of heat-denatured virus particles was studied using poliovirus type 1, strain chat and echovirus type 6, strain d'amori. six recovery media were chosen to simulate heat-processed foods and mildly processed or raw foods and to represent a range of compositions. virus was suspended in four heating media and processed to various degrees of inactivation. after cooling, the stressed virus was resuspended in the recovery media and incubated at 30 c for up to 7 days. titers were d ... | 1981 | 30856757 |
| multivariate profiling of african green monkey and rhesus macaque t lymphocytes. | the complexity of immune responses limits the usefulness of univariate methods in answering complex immunology questions. to demonstrate the utility of a multivariate approach, we employ such approach to compare t cells of african green monkeys (agms) and rhesus macaques (rms). among the most prominent distinguishing features we found were lower cd3 and higher cd28 surface expression in agms compared to rms. after in vitro stimulation, a larger proportion of agm t cells secreted cytokines, espec ... | 2019 | 30886198 |
| effect of blue light-emitting diode light and antioxidant potential in a somatic cell. | light is an indispensable part of routine laboratory work in which conventional light is generally used. light-emitting diodes (leds) have come to replace conventional light, and thus could be a potent target in biomedical studies. since blue light is a major component of visible light wavelength, in this study, using a somatic cell from the african green monkey kidney, we assessed the possible consequences of the blue spectra of led light in future animal experiments and proposed a potent mitig ... | 2019 | 30958611 |
| a method for recovery of poliovirus 1 from a variety of foods. | a method was developed for the recovery of low numbers of plaque-forming units (pfu) of inoculated poliovirus type 1 from seven different foods. viruses were eluted at ph 9.0 from 25-g food test portions, concentrated at ph 4.5, and eluted at ph 7.5. the final eluates were assayed for pfu in african green monkey kidney (bgm) cell monolayers. the average virus input ranged from 55 to 79 pfu per unit portion. the average percent recoveries were as follows: potato salad, 61; radishes, 54; celery, 4 ... | 1986 | 30959716 |
| should monkeys wash their hands and feet: a pilot-study on sources of zoonotic parasite exposure. | human exposure to zoonotic parasites via contaminated soil is a much studied area. less research has been performed on exposure via contact with animals and surfaces such as picnic tables with which infected animals might be in contact. on st. kitts, wild african green monkeys (agm; chlorocebus aethiops sabaeus), which are known to have zoonotic parasites, roam freely in areas with outdoor dining facilities and are used in the tourist industry. in this study, the hands and feet of eight agm and ... | 2019 | 30963089 |
| generation of erk-independent human and non-human primate pluripotent stem cells. | the production of human organs inside human-animal interspecies chimeras might one day comprise a viable strategy for generating patient-specific organs, but such experiments will require human chimera-competent pluripotent stem (ps) cells. the stabilization of ps cell self-renewal in serum-free medium and erk blockade might be critical for capturing primate chimera-competent pluripotency. it has recently been shown that shielding primate cells from the activation of erk, wnt, and pkc signaling ... | 2019 | 30995363 |
| cytotoxicity screening of supercritical fluid extracted seaweeds and phenylpropanoids. | detached leaves of posidonia oceanica and zostera marina creating nuisance at the shores were extracted by means of supercritical co2 enriched with a co-solvent, compared with that of soxhlet extraction. the extracts and their active compounds which are phenylpropanoids (chicoric, p-coumaric, rosmarinic, benzoic, ferulic and caffeic acids) were screened for cytotoxicity in cancer cell lines including human breast adenocarcinoma (mcf-7, mda-mb-231, sk-br-3), human colon adenocarcinoma (ht-29), hu ... | 2019 | 31004301 |
| molecular species identification of trichuris trichiura in african green monkey on st. kitts, west indies. | the population of african green monkeys (agm, chlorocebus aethiops sabaeus) on st. kitts, west indies is believed to be as large as or greater than the human population. interactions with humans are frequent and the pathogens carried by agm, such as trichuris spp., may pose a risk to humans. the objectives of this study were to assess the use of molecular methods for diagnosing trichuris spp. in agm and compare its dna sequences to those of trichuris spp. found in other non-human primates and hu ... | 2018 | 31014613 |
| robust synthesis of size-dispersal triangular silver nanoprisms via chemical reduction route and their cytotoxicity. | triangular silver nanocrystals, well-known as nanoprisms (ag-nprs), were successfully developed via a robust and straightforward direct chemical reduction synthetic approach, producing desirable tiny and well-controlled ag-nprs. this procedure was accomplished by fabricating a mixture of di-sodium succinate hexa-hydrate (dssh) and tri-sodium citrate di-hydrate (tscd) as capping agents at optimal synthetic conditions and under an open-air condition, which proved to be an enormous challenge. addit ... | 2019 | 31052386 |
| glycerol monolaurate nanocapsules for biomedical applications: in vitro toxicological studies. | the glycerol monolaurate (gml) is a surfactant used in the food industry and has potent antimicrobial activity against many microorganisms; however, the use of gml is not expanded due its high melting point and poor solubility in water. the aim of the study was to produce, characterize, and evaluate in vitro the cytotoxicity of gml and gml nanocapsules. the gml nanocapsules were produced and characterized by a mean diameter, zeta potential, and polydispersity index. the cytotoxicity was evaluate ... | 2019 | 31079199 |
| use of single-injection recombinant vesicular stomatitis virus vaccine to protect nonhuman primates against lethal nipah virus disease. | nipah virus (niv) is a zoonotic pathogen that causes high case-fatality rates (cfrs) in humans. two niv strains have caused outbreaks: the malaysia strain (nivm), discovered in 1998-1999 in malaysia and singapore (≈40% cfr); and the bangladesh strain (nivb), discovered in bangladesh and india in 2001 (≈80% cfr). recently, nivb in african green monkeys resulted in a more severe and lethal disease than nivm. no niv vaccines or treatments are licensed for human use. we assessed replication-restrict ... | 2019 | 31107231 |
| conserved alarm calls but rapid auditory learning in monkey responses to novel flying objects. | to evaluate the flexibility in vocal production and comprehension in a non-human primate, we presented a drone to west african green monkeys, chlorocebus sabaeus. calls given in response to the drone were clearly distinct from those given to other predators, but highly similar to the aerial alarm calls of the east african vervet monkey, chlorocebus pygerythrus, suggesting that call structure is conserved. to probe how rapidly the animals attached meaning to the sound of the drone, we played back ... | 2019 | 31133723 |
| comparison of hep-2 and vero cell responses reveal unique proapoptotic activities of the herpes simplex virus type 1 α0 gene transcript and product. | previous studies have provided evidence suggesting a role for apoptosis in the control of herpes simplex virus 1 (hsv-1) latency. hsv-1 induces and then later blocks apoptosis in infected cells. the immediate early viral gene α0, which synthesizes the icp0 protein, is necessary and sufficient for hsv-1-induced apoptosis in human epithelial (hep-2) cells. while previous research showed that icp0 protein synthesis is not necessary for hsv-1-induced apoptosis in infected hep-2 cells, circumstantial ... | 2019 | 31139162 |
| remdesivir (gs-5734) protects african green monkeys from nipah virus challenge. | nipah virus is an emerging pathogen in the paramyxoviridae family. upon transmission of nipah virus from its natural reservoir, pteropus spp. fruit bats, to humans, it causes respiratory and neurological disease with a case-fatality rate about 70%. human-to-human transmission has been observed during nipah virus outbreaks in bangladesh and india. a therapeutic treatment for nipah virus disease is urgently needed. here, we tested the efficacy of remdesivir (gs-5734), a broad-acting antiviral nucl ... | 2019 | 31142680 |
| serological evidence of zika virus infection in non-human primates in zambia. | zika virus (zikv) circulation occurs between non-human primates (nhps) in a sylvatic transmission cycle. to investigate evidence of flavivirus infection in nhps in zambia, we performed a plaque reduction neutralization test (prnt) to quantify neutralizing antibodies. prnt revealed that sera from nhps (african green monkeys and baboons) exhibited neutralizing activity against zikv (34.4%; 33/96), whereas a prnt for yellow fever virus using nhp sera showed no neutralization activity. zikv genomic ... | 2019 | 31154511 |
| analysis of nipah virus codon usage and adaptation to hosts. | a recent outbreak of nipah virus (niv) in india has caused 17 deaths in people living in districts of kerala state. its zoonotic nature, as well as high rate of human-to-human transmission, has led researchers worldwide to work toward understanding the different aspects of the niv. we performed a codon usage analysis, based on publicly available nucleotide sequences of niv and its host adaptation, along with other members of the henipavirus genus in ten hosts. niv genome encodes nine open readin ... | 2019 | 31156564 |
| peripheral immune response in the african green monkey model following nipah-malaysia virus exposure by intermediate-size particle aerosol. | the ability to appropriately mimic human disease is critical for using animal models as a tool for understanding virus pathogenesis. in the case of nipah virus (niv), infection of humans appears to occur either through inhalation, contact with or consumption of infected material. in two of these circumstances, respiratory or sinusoidal exposure represents a likely route of infection. in this study, intermediate-size aerosol particles (~7 μm) of niv-malaysia were used to mimic potential routes of ... | 2019 | 31166946 |
| adventitious virus detection in cells by high-throughput sequencing of newly synthesized rnas: unambiguous differentiation of cell infection from carryover of viral nucleic acids. | the use of high-throughput sequencing (hts) to identify viruses in biologicals differs from current molecular approaches, since its use enables an unbiased approach to detection without the need to design specific primers to preamplify target sequences. its broad range of detection and analytical sensitivity make it an important tool to ensure that biologicals are free from adventitious viruses. similar to other molecular methods, however, identification of viral sequences in cells by hts does n ... | 2019 | 31167947 |
| extraintestinal acanthocephalan oncicola venezuelensis (oligacanthorhynchidae) in small indian mongooses (herpestes auropunctatus) and african green monkeys (chlorocebus aethiops sabaeus). | we identified multiple extraintestinal cystacanths during routine postmortem examination of 3 small indian mongooses and 2 african green monkeys from the caribbean island of st. kitts. in mongooses, cystacanths were encysted or free in the subcutaneous tissue, skeletal muscle, or peritoneal or pericardial cavities, whereas in the monkeys, they were in the cavity and parietal layer of the, tunica vaginalis, skeletal muscle, and peritoneal cavity. morphological, histological, and molecular charact ... | 2019 | 31170895 |
| embryonic chimeras with human pluripotent stem cells. | human pluripotent stem (ps) cells can be isolated from preimplantation embryos or by reprogramming of somatic cells or germline progenitors. human ps cells are considered the "holy grail" of regenerative medicine because they have the potential to form all cell types of the adult body. because of their similarity to humans, nonhuman primate (nhp) ps cells are also important models for studying human biology and disease, as well as for developing therapeutic strategies and test bed for cell repla ... | 2019 | 31175650 |
| cytotoxicity and cell cycle analysis of asparagus laricinus burch. and senecio asperulus dc. on breast and prostate cancer cell lines. | medicinal plants play an important role in our african communities for treatment and prevention of various diseases including cancer. this study was aimed on evaluating the cytotoxicity activities of asparagus laricinus burch. and senecio asperulus dc. | 2019 | 31193085 |
| natural ace inhibitory peptides discovery from spirulina (arthrospira platensis) strain c1. | bioactive peptides from natural sources are utilized as food supplements for disease prevention and are increasingly becoming targets for drug discovery due to their specificity, efficacy and the absence of undesirable side effects, among others. hence, the 'spirpep' platform was developed to facilitate the in silico-based bioactive peptide discovery of these highly sought-after biomolecules from spirulina(arthrospira platensis) and to select the protease (thermolysin) used for in vitro digestio ... | 2019 | 31229668 |
| the effect of hyperglycinemic treatment in captive-bred vervet monkeys (chlorocebus aethiops). | nonketotic hyperglycinemia (nkh) is a neuro-metabolic disorder caused by a deficiency in the glycine cleavage system (gcs) and glycine transporter 1 (glyt1). a case of atypical late onset of nkh has been reported in a colony of captive-bred vervet monkeys. the purpose of this study was to evaluate the effect of sodium benzoate and dextromethorphan in reducing glycine levels in hyperglycinemic monkeys. twelve captive-bred vervet monkeys were assigned into three groups consisting of four animals ( ... | 2019 | 31230217 |
| in vitro antimicrobial effects of hypoxis hemerocallidea against six pathogens with dermatological relevance and its phytochemical characterization and cytotoxicity evaluation. | hypoxis hemerocallidea (commonly known as african potato) is popular in african traditional medicine. it is used in the management of diverse ailments including burns, wounds and skin-related diseases. | 2019 | 31265885 |
| dynamic gut microbiome changes following regional intestinal lymphatic obstruction in primates. | the pathogenesis of inflammatory bowel disease (ibd) has been linked with lymphostasis, but whether and how lymphatic obstruction might disturb the intestinal microbiome in the setting of crohn's disease (cd) is currently unknown. we employed a new model of cd in african green monkeys, termed 'atlas' (african green monkey truncation of lymphatics with obstruction and sclerosis), to evaluate how gut lymphatic obstruction alters the intestinal microbiome at 7, 21 and 61 days. remarkable changes in ... | 2020 | 31301989 |
| application of benzonase in preparation of decellularized lamellar porcine corneal stroma for lamellar keratoplasty. | this study was to develop anovel and efficient method using endonuclease (benzonase) to preparedecellularized lamellar porcine corneal stroma (dlpcs). the dlpcs was preparedfrom native lamellar porcine corneal stroma (nlpcs) and was treated with 1000 u/ml benzonase for 5hours. we conducted the following measurements and animal transplantation tocompare dlpcs and nlpcs. the residual dna was decreased significantly from 367.13 ± 19.96 ng/mg to 15.41 ± 0.65 ng/mg after treatment of benzonase by the ... | 2019 | 31330094 |
| microbial translocation into amniotic fluid of vervet monkeys is common and unrelated to adverse infant outcomes. | amniotic fluid was collected from pregnant female african green monkeys (n = 20). analyses indicate microbial translocation into amniotic fluid during pregnancy is typical, and microbial load reduces across gestation. microbial translocation does not relate to infant outcome or maternal factors. lastly, we demonstrate that sample contamination is easily introduced and detectable. | 2019 | 31338846 |
| nipah virus persists in the brains of nonhuman primate survivors. | nipah virus (niv) is an emerging zoonotic paramyxovirus that causes highly lethal henipavirus encephalitis in humans. survivors develop various neurologic sequelae, including late-onset and relapsing encephalitis, several months up to several years following initial infection. however, the underlying pathology and disease mechanisms of persistent neurologic complications remain unknown. here, we demonstrate persistent niv infection in the brains of grivets that survived experimental exposure to ... | 2019 | 31341108 |
| biodegradable cross-linked chitosan nanoparticles improve anti-candida and anti-biofilm activity of tisth, a peptide identified in the venom gland of the tityus stigmurus scorpion. | among several bioactive peptides identified from the venom glands of the tityus stigmurus scorpion, one peptide with hypotensive action (tisth, tityus stigmurus hypotensin) showed multifunctional and biotechnological applications. the maximum efficacy of this class of compounds can be achieved by immobilizing it in specific and suitable biomaterials or suitable carriers. in this study, distinct entrapment methods of tisth in chitosan nanoparticles was tested using its incorporation (cn-tisth-inc ... | 2019 | 31349502 |
| anticancer activity of water-soluble olsalazine-pamam-dendrimer-salicylic acid-conjugates. | improving the activity and selectivity profile of anticancer agents will require designing drug carrier systems that employ soluble macromolecules. olsalazine-pamam-dendrimer-salicylic acid-conjugates with dendritic arms of different lengths have shown good stability regarding the chemical link between drug and spacer. in this study, the drug release was followed in vitro by ultraviolet (uv) studies. evaluation of the cytotoxicity of the olsalazine-pamam-dendrimer-salicylic acid-conjugates emplo ... | 2019 | 31412571 |
| phytochemical profiling of turbinaria ornata and its antioxidant and anti-proliferative effects. | to analyse the phytochemicals and evaluate the antioxidant and anti-proliferative ability of turbinaria ornata (turner) j. agardh, 1848. | 2017 | 31435259 |
| improvement of the anticancer activity of chlorambucil and ibuprofen via calix[4]arene conjugates. | one of the possible ways of improving the activity and selectivity profile of anticancer agents is to design drug carrier systems employing nanomolecules. calix[4]arene derivatives and chlorambucil and ibuprofen are important compounds that exhibit interesting anticancer properties. | 2019 | 31448714 |
| differential susceptibility & replication potential of vero e6, bhk-21, rd, a-549, c6/36 cells & aedes aegypti mosquitoes to three strains of chikungunya virus. | chikungunya virus (chikv), a mosquito-borne arthritogenic virus causes infections ranging from febrile illness to debilitating polyarthralgia in humans. re-emergence of the virus has affected millions of people in africa and asia since 2004. during the outbreak, a new lineage of the virus has evolved as an adaptation for enhanced replication and transmission by aedes albopictus mosquito. a study was designed to compare the susceptibility of four vertebrate cell lines, namely vero e6 (african gre ... | 2019 | 31496530 |
| antimicrobial activity, antioxidant potential, cytotoxicity and phytochemical profiling of four plants locally used against skin diseases. | although orthodox medications are available for skin diseases, expensive dermatological services have necessitated the use of medicinal plants as a cheaper alternative. this study evaluated the pharmacological and phytochemical profiles of four medicinal plants (drimia sanguinea, elephantorrhiza elephantina, helichrysum paronychioides, and senecio longiflorus) used for treating skin diseases. petroleum ether and 50% methanol extracts of the plants were screened for antimicrobial activity against ... | 2019 | 31540194 |
| identification of a novel simian immunodeficiency virus-infected african green monkey (chlorocebus tantalus) confirms that tantalus monkeys in cameroon are infected with a mosaic sivagm lineage. | in this study we report on the identification of a simian immunodeficiency virus (siv) infecting a chlorocebus tantalus from cameroon. the isolate, sivagmtan-ca1, was molecularly characterized by sequencing partial genome (∼4,000 bp) using the conventional sanger method and the oxford nanopore technology (ont). in pol and gp41/nef sivagmtan-ca1 clusters with sivagmsab infecting chlorocebus sabaeus from west africa, whereas in env-gp120 it clusters with sivagmtan infecting c. tantalus from centra ... | 2020 | 31547667 |
| endogenous specialized proresolving mediator profiles in a novel experimental model of lymphatic obstruction and intestinal inflammation in african green monkeys. | changes in the intestinal lymphatic vascular system, such as lymphatic obstruction, are characteristic features of inflammatory bowel diseases. the lymphatic vasculature forms a conduit to enable resolution of inflammation; this process is driven by specialized endogenous proresolving mediators (spms). to evaluate contributions of lymphatic obstruction to intestinal inflammation and to study profiles of spms, we generated a novel animal model of lymphatic obstruction using african green monkeys. ... | 2019 | 31547920 |
| type-2-diabetes alters csf but not plasma metabolomic and ad risk profiles in vervet monkeys. | epidemiological studies suggest that individuals with type 2 diabetes (t2d) have a twofold to fourfold increased risk for developing alzheimer's disease (ad), however, the exact mechanisms linking the two diseases are unknown. in both conditions, the majority of pathophysiological changes, including glucose and insulin dysregulation, insulin resistance, and ad-related changes in aβ and tau, occur decades before the onset of clinical symptoms and diagnosis. in this study, we investigated the rela ... | 2019 | 31555072 |
| evaluation of drug candidature: in silico admet, binding interactions with cdk7 and normal cell line studies of potentially anti-breast cancer enamidines. | we have recently explored novel class of potentially anti-breast cancer active enamidines in which four molecules 4a-c and 4h showed higher anticancer activity compared to standard drug doxorubicin. as a part of extension of this work, we have further evaluated in silico cheminformatic studies on bioactivity prediction of synthesized series of enamidines using mole information. the normal cell line study of four lead compounds 4a-c and 4h against african green monkey kidney vero strain further r ... | 2019 | 31563021 |
| integrin αvβ3 enhances replication of porcine epidemic diarrhea virus on vero e6 and porcine intestinal epithelial cells. | the entry mechanism of porcine epidemic diarrhea virus (pedv) remains unclear, especially the virus receptor. our previous study revealed a potential correlation between integrin αvβ3 and pedv infection. in the current study, the effect of overexpression, silencing, antibody inhibition, and co-expression with porcine aminopeptidase n (papn) of integrin αvβ3 on pedv infection was investigated and analyzed in african green monkey vero e6 cells and porcine intestinal epithelial cells (iecs) using t ... | 2019 | 31585640 |
| myrislignan exhibits activities against toxoplasma gondii rh strain by triggering mitochondrial dysfunction. | toxoplasma gondii is a widespread obligatory parasitic protozoon that infects nearly all warm-blooded animals and causes toxoplasmosis. however, the current treatments for toxoplasmosis are limited by severe side effects. myrislignan is a natural product from myristica fragrans houtt with wide pharmacological activities. in the current study, we tested the anti-t. gondii activity of myrislignan both in vitro and in vivo and explored its potential mechanism of action. the cytotoxicity of myrislig ... | 2019 | 31620108 |
| a lethal aerosol exposure model of nipah virus strain bangladesh in african green monkeys. | the high case-fatality rates and potential for use as a biological weapon make nipah virus (niv) a significant public health concern. previous studies assessing the pathogenic potential of niv delivered by the aerosol route in african green monkeys (agms) used the malaysia strain (nivm), which has caused lower instances of respiratory illness and person-to-person transmission during human outbreaks than the bangladesh strain (nivb). accordingly, we developed a small particle aerosol model of niv ... | 2020 | 31665351 |
| an intranasal exposure model of lethal nipah virus infection in african green monkeys. | due to the difficulty in conducting clinical trials for vaccines and treatments against nipah virus (niv), licensure will likely require animal models, most importantly non-human primates (nhps). the nhp models of infection have primarily relied on intratracheal instillation or small particle aerosolization of niv. however, neither of these routes adequately models natural mucosal exposure to niv. to develop a more natural nhp model, we challenged african green monkeys with the bangladesh strain ... | 2020 | 31665362 |
| development of cystoisospora felis in cell culture and in vitro formation of monozoic tissue cysts. | cystoisospora felis is a coccidian parasite commonly found in feces of domestic cats. infection in cats occurs by ingestion of sporulated oocysts or consumption of rodents infected by the parasite. scarce information is available about extraintestinal stages of c. felis in naturally infected intermediate hosts, as well as in cell culture. the aim of the current work was to investigate the development of c. felis in vero cells (african green monkey kidney) and mdck cells (madin-darby canine kidne ... | 2019 | 31681814 |
| the use of large-particle aerosol exposure to nipah virus to mimic human neurological disease manifestations in the african green monkey. | nipah virus (niv) is an emerging virus associated with outbreaks of acute respiratory disease and encephalitis. to develop a neurological model for niv infection, we exposed 6 adult african green monkeys to a large-particle (approximately 12 μm) aerosol containing niv (malaysian isolate). brain magnetic resonance images were obtained at baseline, every 3 days after exposure for 2 weeks, and then weekly until week 8 after exposure. four of six animals showed abnormalities reminiscent of human dis ... | 2020 | 31687756 |
| macrophage-associated wound healing contributes to african green monkey siv pathogenesis control. | natural hosts of simian immunodeficiency virus (siv) avoid aids despite lifelong infection. here, we examined how this outcome is achieved by comparing a natural siv host, african green monkey (agm) to an aids susceptible species, rhesus macaque (rm). to asses gene expression profiles from acutely siv infected agms and rms, we developed a systems biology approach termed conserved gene signature analysis (cgsa), which compared rna sequencing data from rectal agm and rm tissues to various other sp ... | 2019 | 31704931 |
| high-fat diet exacerbates siv pathogenesis and accelerates disease progression. | consuming a high-fat diet (hfd) is a risk factor for obesity and diabetes; both of these diseases are also associated with systemic inflammation, similar to hiv infection. a hfd induces intestinal dysbiosis and impairs liver function and coagulation, with a potential negative impact on hiv/siv pathogenesis. we administered a hfd rich in saturated fats and cholesterol to nonpathogenic (african green monkeys) and pathogenic (pigtailed macaques) siv hosts. the hfd had a negative impact on siv disea ... | 2019 | 31710311 |
| hemagglutinin head-specific responses dominate over stem-specific responses following prime boost with mismatched vaccines. | broadly neutralizing abs targeting the ha stem can provide broad protection against different influenza subtypes, raising the question of how best to elicit such abs. we have previously demonstrated that vaccination with pandemic live-attenuated influenza vaccine (plaiv) establishes immune memory for ha head-specific abs. here, we determine the extent to which matched versus mismatched laiv-inactivated subunit vaccine (iiv) prime-boost vaccination elicits stem-specific memory b cells and abs. we ... | 2019 | 31723058 |
| initial attachment of borrelia burgdorferi spirochetes to vero cells. | adhesion is the initial process in the establishment of any infection and can contribute to bacterial pathogenesis. without the ability to adhere to host cell surface, there is no invasion, dissemination, or persistence and host colonization by many bacterial pathogens, including b. burgdorferi. during the infection, b. burgdorferi cells interact with cells of various origins. we are having limited information and knowledge regarding the borrelial invasion, intracellular existence and the host c ... | 2019 | 31747771 |
| a novel field-deployable method for sequencing and analyses of henipavirus genomes from complex samples on the minion platform. | viruses in the genus henipavirus encompass 2 highly pathogenic emerging zoonotic pathogens, hendra virus (hev) and nipah virus (niv). despite the impact on human health, there is currently limited full-genome sequence information available for henipaviruses. this lack of full-length genomes hampers our ability to understand the molecular drivers of henipavirus emergence. furthermore, rapidly deployable viral genome sequencing can be an integral part of outbreak response and epidemiological inves ... | 2020 | 31784761 |
| a preliminary survey of medium and large-sized mammals from lebu natural protected forest, southwest showa, ethiopia. | this study was conducted to determine the species composition and diversity of medium and large-sized mammals from lebu natural protected forest, ethiopia. surveys were conducted to record mammals through direct observation and indirect evidence from three habitat types, namely: natural forest, bushland, and riverine forest. a total of 15 mammalian species were recorded. the species recorded were papio anubis, chlorocebus aethiops, tragelaphus scriptus, canis aureus, crocuta crocuta, panthera pa ... | 2019 | 31832163 |
| author correction: macrophage-associated wound healing contributes to african green monkey siv pathogenesis control. | an amendment to this paper has been published and can be accessed via a link at the top of the paper. | 2019 | 31836755 |
| st. kitts green monkeys originate from west africa: genetic evidence from feces. | sequencing of a fragment of mitochondrial dna extracted from droppings of a green monkey inhabiting the caribbean island of st. kitts, and comparing the obtained sequence with sequences determined earlier for the four recognized subspecies of african green monkeys, showed that this monkey can be classified as cercopithecus aethiops sabaeus, and thus originates from west africa. as the ancestors of the monkeys reached the island by ships involved in the slave trade in the 17th to 18th centuries, ... | 1996 | 31918521 |
| seasonal and social correlates of changes in hair, skin, and scrotal condition in vervet monkeys (cercopithecus aethiops) of amboseli national park, kenya. | in a 20-month study of six groups of vervet monkeys (cercopithecus aethiops) in amboseli national park, kenya, i documented changes in hair loss in all individuals, and scrotal color and hyperpigmentation in all adult males. hair loss occurred seasonally and was most pronounced in low-ranking individuals, especially males. the mean shade of scrotal color for all males and the percentage of males with scrotal hyperpigmentation both covaried with hair loss over time. scrotal color was strongly neg ... | 1995 | 31924083 |
| human immunodeficiency virus type-1 tat protein induces secretory leukocyte protease inhibitor expression in african green monkey but not human cells. | african monkeys are resistant to hiv-1 infection due to intrinsic restriction mechanisms found in their cells. however, although they can be infected by monkey-adapted modified hiv-1 particles that are designed to overcome known restriction factors, virus numbers drop to undetectable levels in immunocompetent animals. these results indicate the possibility of the presence of yet unidentified factor(s) that restrict hiv-1 in old-world monkey (owm) cells after integration of the viral genome into ... | 2020 | 31925640 |
| twinning in a colony of vervet monkeys (cercopithecus aethiops sabaeus). | from 1975 through 1991, three sets of twins were born from a total of 693 live and stillborn births (0.43%) at the ucla/sepulveda veterans administration medical center nonhuman primate research laboratory, ca. none of the twin's mothers were related. positive patrilineal relationships have not been established; however, a brother (not a twin) of the first set of twins may have fathered the third set. all twins were born to multiparous females and, in each case, only one infant survived beyond 4 ... | 1994 | 31936905 |