Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| the new age of acne therapy: light, lasers, and radiofrequency. | background: current treatments for acne vulgaris include topical and oral medications that counteract microcomedone formation, sebum production, propionibacterium acnes, and inflammation. concerns about the short- and long-term consequences of these medications, along with technological advancements, have to significant progress in the management of acne. these developments include light, laser, and radio frequency, which may offer faster onset of action, equal or greater efficacy, and greater c ... | 2004 | 16020203 |
| induction of a chemoattractive proinflammatory cytokine response after stimulation of keratinocytes with propionibacterium acnes and coproporphyrin iii. | the inflammation in acne vulgaris is widely thought to be induced by an immunological reaction, but the role of propionibacterium acnes is unclear. | 2005 | 16029328 |
| propionibacterium acnes. a cause of pneumatocele associated pneumonia. | propionibacterium acnes is a normal inhabitant of the skin and mucosal surfaces and is rarely identified as a cause of significant infection. reports of chest infections by this organism are limited. we report a case of pneumatocele-associated pneumonia caused by this organism and review the literature. | 2005 | 16047068 |
| propionibacterium acnes wound contamination at the time of spinal surgery. | bacteria of the normal skin microbiota such as propionibacterium acnes and coagulase-negative staphylococci often are dismissed as contaminants when detected in clinical samples. propionibacterium acnes is described as a cause of spinal infection and more recently has been linked to sciatica. to date no researchers formally have examined the incidence of bacterial wound contamination during spinal surgery. surgical specimens were removed from 79 patients having spinal surgery for analysis using ... | 2005 | 16056028 |
| introduction: welcome to the next generation of acne research. | 2005 | 16092792 | |
| insights in the pathogenic potential of propionibacterium acnes from its complete genome. | one of the long-lasting open questions in understanding acne is the role of the skin bacterium propionibacterium acnes. opinions within the scientific community diverge regarding the importance of this gram-positive bacterium not only in acne but also in other p. acnes-associated diseases. the recently decoded genome gives us some clues with respect to its pathogenic potential and its strategies to survive in the harsh environment of human skin. this review focuses on the major findings of the g ... | 2005 | 16092793 |
| implications for the role of diet in acne. | within the dermatology community, a general consensus has emerged that diet is unrelated to the etiology of acne. except for 2 poorly designed studies, now more than 30 years old, there are few objective data to support this notion. in contrast, a large body of evidence now exists showing how diet may directly or indirectly influence the following 5 proximate causes of acne: (1) increased proliferation of basal keratinocytes within the pilosebaceous duct, (2) incomplete separation of ductal corn ... | 2005 | 16092796 |
| hormonal therapy for acne using oral contraceptive pills. | the etiology of acne vulgaris is multifactorial and complex. the four key factors involved in the development of acne include follicular plugging, inflammation, the presence and activity of propionibacterium acnes, and sebum. androgen hormones stimulate the sebaceous gland and promote sebum excretion. therefore, therapies that have an overall antiandrogen effect, like combination oral contraceptive pills, may be useful in the management of acne vulgaris. numerous combination oral contraceptive p ... | 2005 | 16092798 |
| lasers and light therapy for acne vulgaris. | acne vulgaris remains an emotionally and debilitating dermatologic disease, and is conventionally treated with a variety of oral and topical therapies with a number of significant side effects. an evolving understanding of laser-tissue interactions involving propionibacterium acnes-produced porphyrins, and the development of infrared nonablative lasers to target sebaceous glands, has lead to the development of an escalating number of laser, light and radiofrequency devices for acne. used as mono ... | 2005 | 16092799 |
| granulysin-derived peptides demonstrate antimicrobial and anti-inflammatory effects against propionibacterium acnes. | propionibacterium acnes is a key therapeutic target in acne, yet this bacterium has become resistant to standard antibiotic agents. we investigated whether the human antimicrobial protein granulysin is a potential candidate for the treatment of acne. granulysin and synthetic granulysin-derived peptides possessing a helix-loop-helix motif killed p. acnes in vitro. modification of a helix-loop-helix peptide, 31-50, by substitution of a tryptophan for the valine at amino acid 44 (peptide 31-50v44w) ... | 2005 | 16098035 |
| current use of anti-infectives in dermatology. | dermatologic diseases encompass a broad category of pathologic situations. infection remains a significant aspect of the pathology faced in patient encounters, and it is natural to expect that anti-infectives play a major element in the armamentarium utilized by dermatologists. aside from the treatment of the classic bacterial and fungal infections, there are now new uses for antiviral agents to help suppress recurrent disease, such as herpes simplex. there is also the novel approach of using an ... | 2005 | 16107197 |
| evaluation of bact/alert plastic culture bottles for use in testing pooled whole blood-derived leukoreduced platelet-rich plasma platelets with a single contaminated unit. | in certain countries, whole blood-derived platelet (plt)-rich plasma plts can only be pooled within 4 hours of transfusion. one prerequisite for prestorage pooling is the ability to detect low levels of bacteria from a single unit (approx. 10 colony-forming units [cfus]/ml) once pooled (10/6 approx. 2 cfus/ml). this study evaluated the bact/alert (biomérieux) for detection of bacteria in 1 unit of a 6-unit pool. | 2005 | 16131385 |
| microbiology of acute exacerbation of chronic sinusitis. | we undertook to evaluate the microbiology of acute exacerbation of chronic sinusitis (aecs). | 2005 | 16134356 |
| infectious keratitis in the corneal graft: treatment with partial conjunctival flaps. | the infection of the corneal graft is one of the most serious complications following keratoplasty. in many instances, it can be treated successfully with intensive topical and subconjunctival antibiotics. however, when this therapy is ineffective, a surgical approach must be considered. the usefulness of partial conjunctival flaps that spare the visual axis for managing corneal graft infections is reported. | 2005 | 16156146 |
| the pathophysiology of acne. | acne is a multifactorial inflammatory disease affecting pilosebaceous follicles. the initial event in the development of an acne lesion is abnormal desquamation of the keratinocytes that line the sebaceous follicle, which creates a microplug or microcomedo. an increase in circulating androgens at the onset of puberty stimulates the production of sebum into the pilosebaceous unit. these events combine to create an environment within the pilosebaceous unit that is favorable for the colonization of ... | 2005 | 16164150 |
| in vivo evaluation of the effect of essential oil-containing oral strips on salivary bacteria using the checkerboard method. | the aim of this study was to evaluate the antimicrobial effect of essential oil-containing oral strips on different species of the oral microbiota. | 2005 | 16170974 |
| ctla-4ig suppresses liver injury by inhibiting acquired immune responses in a mouse model of fulminant hepatitis. | expression of costimulatory molecules is significantly upregulated in various organs in an animal model of severe hepatitis induced by injection of propionibacterium acnes (p. acnes) and lipopolysaccharide (lps). in the present study, we examined whether blockade of costimulatory signals by ctla-4ig can suppress the liver injury in this model. we injected an adenovirus encoding ctla-4ig (adctla-4ig) into mice 7 days before, on the same day, or 3 days after p. acnes priming. the virus was found t ... | 2005 | 16175605 |
| toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by propioni- bacterium acnes. | recognition of gram-positive bacteria by toll-like receptor 2 (tlr2) induces activation of proinflammatory pathways. in mice, sensitization with the gram-positive propionibacterium acnes followed by a challenge with the tlr4 ligand, lipopolysaccharide (lps), results in fulminant hepatic failure. here, we investigated the role of tlr2 in liver sensitization to lps-induced injury. stimulation of chinese hamster ovary cells and peritoneal macrophages with heat-killed p. acnes required expression of ... | 2005 | 16204620 |
| review of the innate immune response in acne vulgaris: activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. | acne vulgaris is a common disorder that affects 40-50 million people in the usa alone. the pathogenesis of acne is multifactorial, including hormonal, microbiological and immunological mechanisms. one of the factors that contributes to the pathogenesis of acne is propionibacterium acnes; yet, the molecular mechanism by which p. acnes induces inflammation is not known. recent studies have demonstrated that microbial agents trigger cytokine responses via toll-like receptors (tlrs). tlrs are patter ... | 2005 | 16205063 |
| [pathophysiology of acne]. | several pathogenic factors contribute to the development of acne, among them, seborrhea, follicular hyperkeratosis, propionibacteria, and inflammatory events. this article reviews current knowledge of these pathogenic factors. | 2005 | 16215770 |
| [propionibacterium acnes adenitis]. | propionibacterium acnes is a gram-positive pleomorphic rod-shaped anaerobic saprophyte of the skin, mouth and upper respiratory tract. although associated with acne vulgaris, it is otherwise reported as a human pathogen only rarely, in various infections, notably cutaneous and osteoarticular, and in endocarditis. we report here a case of bilateral p. acnes-abscessed adenitis of the inguinal folds. | 2005 | 16225253 |
| amplified-fragment length polymorphism analysis of propionibacterium isolates implicated in contamination of blood products. | propionibacterium acnes is implicated in most cases of bacterial contamination of platelet concentrates (pcs). to determine the source of contamination, amplified-fragment length polymorphism (aflp) analysis was applied. this dna fingerprinting technique was used to study the molecular relationship of 44 isolates derived from 22 pcs and 22 corresponding red blood cells concentrates (rbcs) from the same whole blood donations. the aflp results together with sequencing analysis of the 1,200 bp of t ... | 2005 | 16225662 |
| effect of bacteriocin produced by lactococcus sp. hy 449 on skin-inflammatory bacteria. | this study was carried out to evaluate the effect of bacteriocin produced by lactococcus sp.hy 449 against skin-inflammatory bacteria such as staphylococcus epidermidis atcc 12228, staphylococcus aureus atcc 65389, streptococcus pyogenes atcc 21059, and propionibacterium acnes atcc 6919. the spot-on-the-lawn method was used to determine the antimicrobial activity of bacteriocin against indicator strains on the human skin. the bacteriocin produced by lactococcus sp. hy 449 inhibited the growth of ... | 2006 | 16226831 |
| isolation and characterization of predominant microorganisms during decomposition of waste materials in a field-scale composter. | a self-heating field-scale composter treating agro-industrial wastes within a period of 30 d was analyzed by denaturing gradient gel electrophoresis (dgge) (pedro et al., j. biosci. bioeng., 91, 159-165, 2001). three major bands were derived from propionibacterium acnes, methylobacterium mesophilicum or m. radiotolerans, and bacillus thermocloacae. strains msp09a and msp06g with close affiliation to p. acnes and b. thermocloacae, respectively, were successfully isolated. based on quantitative-pc ... | 2003 | 16233421 |
| bacterial communities in petroleum oil in stockpiles. | bacterial communities in crude-oil samples from japanese oil stockpiles were investigated by 16s rrna gene cloning, followed by denaturing gradient gel electrophoresis (dgge) analysis. 16s rrna genes were successfully amplified by pcr after isooctane treatment from three kinds of crude-oil sample collected at four oil stockpiles in japan. dgge profiles showed that bacteria related to ochrobactrum anthropi, burkholderia cepacia, stenotrophomonas maltophilia, propionibacterium acnes, and brevundim ... | 2005 | 16233771 |
| nitric oxide is not a mediator of inflammation-induced resistance to atracurium. | resistance to atracurium as a result of increased drug binding to alpha1-acid glycoprotein is associated with increased inducible nitric oxide synthase activity and increased nitric oxide levels in plasma. we investigated if the inhibition of inducible nitric oxide synthase and suppression of nitric oxide can reverse the resistance to atracurium. as a model of alpha1-acid glycoprotein and nitric oxide increase, 84 male sprague-dawley rats received an iv injection of either 60 mg/kg corynebacteri ... | 2005 | 16243995 |
| treatment of acne could lead to the better control of cellular autoimmune disorders. | 2006 | 16253429 | |
| involvement of neutrophil recruitment and protease-activated receptor 2 activation in the induction of il-18 in mice. | activated neutrophils produce serine proteases, which activate cells through protease-activated receptor 2 (par2). as proteinase 3 (pr3) induces the secretion of interleukin (il)-18 from epithelial cells in combination with lipopolysaccharide (lps) in vitro, we examined whether neutrophils, serine proteases, and par2 are involved in the induction of serum il-18 and il-18-dependent liver injury in mice treated with heat-killed propionibacterium acnes and lps. lps-induced serum il-18 levels in p. ... | 2005 | 16260585 |
| optimal sampling time after preparation of platelet concentrates for detection of bacterial contamination by quantitative real-time polymerase chain reaction. | a universal quantitative real-time polymerase chain reaction (pcr), based on bacterial 16s rdna, to detect bacterial contamination of platelet concentrates (pcs), was developed previously and compared with automated culturing. in the present study, this real-time pcr method was evaluated to determine the optimal sampling time for screening of bacterial contamination in pcs. | 2005 | 16262753 |
| detection of potentially novel bacterial components of the human skin microbiota using culture-independent molecular profiling. | although the micro-organisms forming the cutaneous microbiota are considered to play important roles in the modification and prevention of skin diseases, a comprehensive analysis of their composition has not yet been carried out because of difficulties in determining yet-to-be-cultured micro-organisms in the samples. swab-scrubbed forehead skin samples of five healthy volunteers were analysed by profiling 16s rrna genes, as well as by conventional culture methods, to provide a profile of the cut ... | 2005 | 16278439 |
| very low dose isotretinoin is effective in controlling seborrhea. | excessive seborrhea, coarse-pored skin, minimal acne and oily scalp hair comprise a well-known clinical entity. it causes considerable concern, has social impact, and affects the quality of life in some individuals. some patients seek treatment for seborrhea. no effective topical sebosuppressive medication is available. oral isotretinoin is the only remedy for men. in women, oral isotretinoin is the most effective remedy, followed by antiandrogens. | 2003 | 16285647 |
| endocarditis caused by propionibacterium acnes: an easily ignored pathogen. | propionibacterium acnes, which usually considered as a contaminant, has been found to be an emerging pathogen in human diseases. we describe a case of prosthetic valve related endocarditis caused by p. acnes. sequencing of the genetic coding of 16s ribosomal rna was used to identify the pathogen and random amplified polymorphic dna patterns further confirmed the persistent bacteraemia, which help to determine the diagnosis. | 2005 | 16291276 |
| induction of toll-like receptors by propionibacterium acnes. | the bacterium propionibacterium acnes is involved in the induction and maintenance of the inflammatory phase of acne. recent studies have found that keratinocytes express toll-like receptors (tlrs) implicated in immediate immunity. no studies have, to date, been carried out on the action of p. acnes upon tlr activation in keratinocytes. | 2005 | 16307644 |
| in vitro bactericidal activity of the glycopeptide compounds vancomycin, teicoplanin and ramoplanin (a-16686/mdl 62,198). | 1989 | 16312373 | |
| arthroplastic and osteosynthetic infections due to propionibacterium acnes: a retrospective study of 52 cases, 1995-2002. | the cases of 52 patients with propionibacterium acnes infection of orthopaedic implants are summarized: 20 patients with definite infection (sepsis, with p. acnes recovered from multiple specimens per patient), 15 with probable infection (sepsis, with p. acnes recovered from one specimen), and 17 with possible infection (signs of prosthetic malfunction or pseudo-osteoarthritis, with p. acnes recovered from one specimen). the patient population consisted of 37 males and 15 females with a mean age ... | 2005 | 16328558 |
| polymerase chain reaction for the rapid detection of cerebrospinal fluid shunt or ventriculostomy infections. | infection after cerebrospinal fluid (csf) shunts or ventriculostomies is a common complication associated with significant morbidity and mortality. polymerase chain reaction (pcr) is a powerful molecular technique that allows rapid and precise amplification of bacterial deoxyribonucleic acid (dna) and has proven a powerful tool in the detection of a wide variety of clinically important infectious diseases. we analyzed specimens of csf derived from ventriculoperitoneal shunts or external ventricu ... | 2005 | 16331172 |
| research snippets from the british journal of dermatology. 2005. | 2005 | 16354169 | |
| delayed-onset endophthalmitis following cataract surgery caused by acremonium strictum. | this case represents the first report of acremonium strictum endophthalmitis. endophthalmitis caused by a. strictum may share clinical features typical of endophthalmitis due to propionibacterium acnes (such as delayed onset of the infection and white plaque-like material in the capsular bag). | 2005 | 16355956 |
| infected endoluminal stent-graft: implications for endotension, late endoleaks, and prophylactic antibiotics. | to retrospectively review a case of stent-graft infection that presented as continued aneurysm expansion after endoluminal repair. | 2005 | 16363894 |
| solid lipid microparticles (slm) containing juniper oil as anti-acne topical carriers: preliminary studies. | solid lipid microparticles (slm) were used as carriers of juniper oil and proposed for the topical treatment of acne vulgare. the formulations were obtained by the o/w emulsification method. compritol and precirol were employed as lipidic materials. emulsions containing 1.5% (w/w) of lipophilic phase (lipid and oil) and two different lipid to oil ratios (1:1 and 2:1) were prepared. blank particles were also prepared, as a comparison. the slm were characterized in terms of encapsulation efficienc ... | 2005 | 16370177 |
| comparative in vitro activities of retapamulin (sb-275833) against 141 clinical isolates of propionibacterium spp., including 117 p. acnes isolates. | using the nccls agar dilution method, we studied the in vitro activity of retapamulin (sb-275833) against 141 clinical isolates of propionibacterium species, including seven multiresistant strains, and found retapamulin to be the most active agent among those tested with mics of < or = 1 microg/ml against all isolates. | 2006 | 16377717 |
| commensal oral bacteria antigens prime human dendritic cells to induce th1, th2 or treg differentiation. | in various immunopathologic conditions, bacterial flora induce an immune response which results in inflammatory manifestations, e.g. periapical granuloma. dendritic cells provide the main orchestration of specific immune responses. the aim of our study was to test the capacity of distinct oral bacterial antigens (prepared from streptococcus mitis, propionibacterium acnes, and bacteroides spp.) to prime human dendritic cells for stimulation of the t-lymphocyte response. to assess the t-lymphocyte ... | 2006 | 16390334 |
| the temperature dependence of porphyrin production in propionibacterium acnes after incubation with 5-aminolevulinic acid (ala) and its methyl ester (m-ala). | topical pdt treatment of the common skin disease acne vulgaris is now in clinical use. propionibacterium acnes (p. acnes) is known to play an important role in acne. 5-aminolevulinic acid (ala) supplementation leads to an enhanced porphyrin production in the bacteria. subsequent illumination with light of the proper wavelengths can reduce the number of bacteria and this might at least partly explain the pdt effect on acne. we have assessed the effects of temperature on p. acnes washed cell suspe ... | 2006 | 16395429 |
| basics of flow cytometry-based sterility testing of platelet concentrates. | flow cytometry (facs) is a common technique in blood banking. it is used, for example, for the enumeration of residual white blood cells in plasma and in cellular blood products. it was investigated whether it can also be applied for sterility testing of buffy coat-derived platelet concentrates (pcs). | 2006 | 16398729 |
| [propionibacterium acnes infective endocarditis. study of 11 cases and review of literature]. | propionibacterium acnes, a gram positive, anaerobic, skin commensal bacillus, is too often considered a biologic fluid contaminant, of blood cultures in particular. its implication has been shown in various infections, including brain abscess, ocular infections, osteitis, and acne. it is also the cause of infective endocarditis (ie). | 2005 | 16435600 |
| clinical and bacteriological evaluation of nadifloxacin 1% cream in patients with acne vulgaris: a double-blind, phase iii comparison study versus erythromycin 2% cream. | the aim of this double-blind, multinational, phase iii study was to investigate the clinical and bacteriological efficacy of nadifloxacin 1% cream compared with erythromycin 2% cream in 474 european patients with predominantly inflamed slight-to-moderate acne vulgaris. during 12 weeks of treatment both nadifloxacin and erythromycin caused significant reduction in the number of inflamed papulo-pustular lesions (66.7% and 64.7%, respectively) and open and closed comedones. the microbiological eval ... | 2006 | 16436342 |
| the presence of propionibacterium spp. in the vitreous fluid of uveitis patients with sarcoidosis. | 2006 | 16445463 | |
| in vivo and in vitro effect of killed propionibacterium acnes and its purified soluble polysaccharide on mouse bone marrow stem cells and dendritic cell differentiation. | among the effects exerted by propionibacterium acnes, a most relevant one is its capacity to modulate the th1/th2 cellular immune response. this effect depends on the induction and activation of antigen presenting cells, mainly dendritic cells (dcs), whose number is increased in the peripheral blood of animals treated with this bacterium. a soluble p. acnes polysaccharide (ps) extract also acts on dcs, modulating a th1 immune response. these data led us to investigate the role of p. acnes and it ... | 2006 | 16446175 |
| influence of a new surface modification of intraocular lenses with fluoroalkylsilan on the adherence of endophthalmitis-causing bacteria in vitro. | dynasilan is a fluoroalkylsilan that is able to interact with surface active centres on intraocular lenses (iol), offering a new way for surface modification of different iol materials. the purpose of this in vitro study was to investigate the influence of this new surface modification on the adherence of two typical endophthalmitis causing bacteria (staphylococcus epidermidis, propionibacterium acnes). | 2006 | 16453124 |
| production of trans-10, cis-12 conjugated linoleic acid in rice. | conjugated linoleic acid (cla) has anti-carcinogenic and anti-atherosclerosis activity, and modulatory effects on the immune system and lipid metabolism. to produce a transgenic rice plant that can accumulate cla, a linoleate isomerase gene that can convert linoleic acid to trans-10, cis-12 cla was introduced and expressed under the control of seed-specific promoters from the oleosin and globulin genes. the fatty acid composition of the transgenic rice grain was analyzed by gas chromatography. a ... | 2006 | 16475013 |
| structure and mechanism of the propionibacterium acnes polyunsaturated fatty acid isomerase. | conjugated linoleic acids (clas) affect body fat gain, carcinogenesis, insulin resistance, and lipid peroxidation in mammals. several isomers of cla exist, of which the (9z, 11e) and (10e, 12z) isomers have beneficial effects on human metabolism but are scarce in foods. bacterial polyunsaturated fatty acid isomerases are promising biotechnological catalysts for cla production. we describe six crystal structures of the propionibacterium acnes polyunsaturated fatty acid isomerase pai in apo- and p ... | 2006 | 16477020 |
| propionibacterium acnes. | propionibacterium acnes, a common skin organism, is most notably recognized for its role in acne vulgaris. it also causes postoperative and device-related infections and has been associated with a number of other conditions such as sarcoidosis and synovitis, acne, pustulosis, hyperostosis and osteitis (sapho), although its precise role as a causative agent remains to be determined. propionibacterium acnes produces a number of virulence factors and is well known for its inflammatory and immunomod ... | 2006 | 16478502 |
| anterior chamber paracentesis cytology (cytospin technique) for the diagnosis of intraocular lymphoma. | to report on the diagnosis of intraocular lymphoma by aqueous cytology. | 2006 | 16488933 |
| antimicrobial susceptibility of anaerobic bacteria in new zealand: 1999-2003. | routine susceptibility testing of all anaerobic organisms is not advocated, but it is useful for laboratories to test periodically for anaerobic organisms and provide local susceptibility data to guide therapy. this study reports the national trend of antibiotic susceptibility of clinically significant anaerobes in new zealand. | 2006 | 16507560 |
| in-house siras phasing of the polyunsaturated fatty-acid isomerase from propionibacterium acnes. | the polyenoic fatty-acid isomerase from propionibacterium acnes (pai) catalyzes the double-bond isomerization of linoleic acid to conjugated linoleic acid, which is a dairy- or meat-derived fatty acid in the human diet. pai was overproduced in escherichia coli and purified to homogeneity as a yellow-coloured protein. the nature of the bound cofactor was analyzed by absorption and fluorescence spectroscopy. single crystals of pai were obtained in two crystal forms. cubic shaped crystals belong to ... | 2006 | 16511289 |
| long-chain 3-acyl-4-hydroxycoumarins: structure and antibacterial activity. | by reacting 4-hydroxycoumarin with long-chain acyl chlorides, a number of new 3-acyl derivatives were prepared and the relationship was studied between their structures and activities against staphylococcus aureus atcc 6538, staphylococcus epidermidis atcc 12228, and propionibacterium acnes atcc 11827. antibacterial activity was associated with enolic tautomers of a tricarbonylmethane group bearing a lipophilic side chain (undec-10-enoyl, undec-10-ynoyl, palmitoyl or octadec-9-enoyl). a newly sy ... | 2006 | 16511806 |
| gene array expression profiling in acne lesions reveals marked upregulation of genes involved in inflammation and matrix remodeling. | the pathogenesis of acne has been linked to multiple factors such as increased sebum production, inflammation, follicular hyperkeratinization, and the action of propionibacterium acnes within the follicle. in an attempt to understand the specific genes involved in inflammatory acne, we performed gene expression profiling in acne patients. skin biopsies were obtained from an inflammatory papule and from normal skin in six patients with acne. biopsies were also taken from normal skin of six subjec ... | 2006 | 16528362 |
| improved aero-anaerobe recovery from infected prosthetic joint samples taken from 72 patients and collected intraoperatively in rosenow's broth. | recovery of the bacteria responsible for prosthetic joint infections is a major problem, which is due in part to the alteration of their ability to grow by storage during transportation to the laboratory. | 2006 | 16534711 |
| anti-inflammatory activity of cationic peptides: application to the treatment of acne vulgaris. | cationic antimicrobial peptides exhibit potent antimicrobial activity against clinically relevant microorganisms including propionibacterium acnes. recent studies showed that, in addition to the antimicrobial activity, these peptides can exhibit an anti-inflammatory effect. these properties make cationic peptides attractive drug candidates for the treatment of acne vulgaris, a disease with both bacterial and inflammatory components. this review focuses on the anti-inflammatory activity of cation ... | 2006 | 16553825 |
| the taxonomic position of corynebacterium acnes. | 1946 | 16561149 | |
| serological grouping of actinomyces by means of fluorescent antibodies. | slack, john m. (west virginia university, morgantown), ann winger, and dane w. moore, jr. serological grouping of actinomyces by means of fluorescent antibodies. j. bacteriol. 82:54-65. 1961.-serological groups a, b, c and d of actinomyces were established using fluorescent antibody techniques. one hundred and thirty-eight cultures were included in the study. eighty-nine were classed in group a, 15 in b, 13 in c, and 21 in d. the isolates were from patients and animals with actinomycosis and fro ... | 1961 | 16561915 |
| links between propionibacterium acnes and prostate cancer. | incidental foci of prostate cancer are found at autopsy in 30% of men in their third decade, and by their eighth decade more than 75% have histological evidence of cancer. this unprecedented cancer prevalence points to a ubiquitous causative agent or perhaps an interaction between multiple common carcinogenic cofactors. we propose that one of these carcinogens is propionibacterium acnes. several characteristics of prostate cancer suggest the involvement of an infectious agent and we provide evid ... | 2006 | 16563091 |
| protective effects of a neutral polysaccharide isolated from the mycelium of antrodia cinnamomea on propionibacterium acnes and lipopolysaccharide induced hepatic injury in mice. | mycelia of antrodia cinnamomea were extracted with chloroform and hot water. a neutral polysaccharide named acn2a separated from the water extract was purified using 10% ccl3cooh, and repeated column chromatography on hw-65 and de-52 cellulose. its structure was determined by chemical and spectroscopic analyses. acn2a was composed of gal, glc, fuc, man and galn (in the ratio 1:0.24:0.07:0.026:faint), in which an alpha-d-(1-->6)-gal linkage accounted for 73% of all linkages. the ratio of branch p ... | 2006 | 16595952 |
| clinical significance of brand versus generic formulations: focus on oral minocycline. | minocycline is an oral antibiotic widely prescribed throughout the world, primarily for the treatment of acne vulgaris; other uses include the treatment of rosacea and perioral dermatitis. in the united states, propionibacterium acnes resistance is lowest with minocycline compared with other tetracyclines and with erythromycin. the availability of generic formulations of minocycline has created confusion regarding the clinical significance of brand versus generic minocycline products. this artic ... | 2006 | 16610733 |
| adjuvant effect of the propionibacterium acnes and its purified soluble polysaccharide on the immunization with plasmidial dna containing a trypanosoma cruzi gene. | in the present work we investigated the role of killed propionibacterium acnes or a soluble polysaccharide extracted from bacterium cell wall in modulated experimental immunization with plasmidial dna. we used a plasmid, p154/13, containing a gene-encoding catalytic domain of trypanosoma cruzi (t. cruzi) trans-sialidase. as previously described, immunization of balb/c mice with p154/13 elicited humoral, cell-mediated and protective immune responses against t. cruzi infection. in this study we de ... | 2006 | 16625047 |
| propionibacterium acnes dna from an explanted intraocular lens detected by polymerase chain reaction in a case of chronic pseudophakic endophthalmitis. | we report a case of propionibacterium acnes dna from the explanted intraocular lens (iol) a 76-year-old man with delayed-onset chronic endophthalmitis. the detection was by polymerase chain reaction (pcr). slitlamp microscopic examination showed cells and flare in the anterior chamber, keratic precipitates on the endothelium, and multiple white plaques on both surfaces of the iol. propionibacterium acnes dna was found in both the aqueous humor and the explanted iol by pcr. scanning electron micr ... | 2006 | 16631069 |
| [acne therapy with topical benzoyl peroxide, antibiotics and azelaic acid]. | benzoyl peroxide (bpo) was introduced in the treatment of acne in 1934. despite the fact that only few randomized trials have been published, bpo is considered the standard in topical acne treatment. anaerobic bacteria are reduced by oxidative mechanisms and the induction of resistant strains is reduced. topical formulations are available at concentrations of 2.5, 5, 10 and 20 %. the effect is dose-dependent, but the irritation increases with higher concentrations. usually 5 % bpo is sufficient ... | 2006 | 16638058 |
| susceptibility of propionibacterium acnes and staphylococcus epidermidis to killing by mpo-halide system products. implication for taurine bromamine as a new candidate for topical therapy in treating acne vulgaris. | taurine chloramine (taucl) and taurine bromamine (taubr) are the main haloamines produced by activated neutrophils. taucl exerts both anti-inflammatory and microbicidal activities. clinical studies showed that taucl may be useful as an antimicrobial agent in the local treatment of infections. much less is known about taubr. circumstantial evidence suggests that propionibacterium acnes (pa) has a role in the inflammation of acne. available topical therapies include antimicrobial agents which redu ... | 2006 | 16642259 |
| pectin-like acidic polysaccharide from panax ginseng with selective antiadhesive activity against pathogenic bacteria. | previous studies have revealed the inhibitory effects of an acidic polysaccharide purified from the root of panax ginseng against the adhesion of helicobacter pylori to gastric epithelial cells and the ability of porphyromonas gingivalis to agglutinate erythrocytes. in this study, this acidic polysaccharide from p. ginseng, pg-f2, was investigated further, in order to characterize its antiadhesive effects against actinobacillus actinomycetemcomitans, propionibacterium acnes, and staphylococcus a ... | 2006 | 16643869 |
| pulmonary immune responses to propionibacterium acnes in c57bl/6 and balb/c mice. | propionibacterium acnes (pa) is a gram-positive anaerobic bacterium implicated as a putative etiologic agent of sarcoidosis. to characterize the pulmonary immune response to pa, c57bl/6 and balb/c mice were intraperitoneally sensitized and intratracheally challenged with heat-killed bacteria. c57bl/6 mice challenged with pa developed a cellular immune response characterized by elevations in th1 cytokines/chemokines, increased numbers of lymphocytes and macrophages in lung lavage fluid, and perib ... | 2006 | 16645181 |
| the utility of benzoyl peroxide in hydrophase base (brevoxyl) in the treatment of acne vulgaris. | available for more than 5 decades, benzoyl peroxide has been a "workhorse" of acne therapy. the benefits of this agent include reduction in propionibacterium acnes (p. acnes) with decrease in inflammatory lesions, efficacy as both "leave on" and cleanser formulations and reduced emergence of antibiotic-resistant p. acnes strains. as the effect of benzoyl peroxide on p. acnes is a direct toxic effect rather than as a "true" antibiotic, resistance to benzoyl peroxide does not occur and has never b ... | 2006 | 16673802 |
| antimicrobial properties of dead sea black mineral mud. | the unique, black, hypersaline mud mined from the dead sea shores is extensively used in mud packs, masks, and topical body and facial treatments in spas surrounding the lake, and in cosmetic preparations marketed worldwide, but little is known about its antimicrobiological properties. | 2006 | 16700781 |
| antibiotic-resistant propionibacterium acnes on the skin of patients with moderate to severe acne in stockholm. | the objective was to study the prevalence and antibiotic susceptibility patterns of propionibacterium acnes strains isolated from patients with moderate to severe acne in stockholm, sweden and to determine the diversity of pulsed-field gel electrophoresis types among resistant p. acnes strains. one hundred antibiotic-treated patients and 30 non-antibiotic-treated patients with moderate to severe acne participated in the investigation. facial, neck and trunk skin samples were taken with the agar ... | 2004 | 16701513 |
| in vitro activity of oritavancin (ly333328), vancomycin, clindamycin, and metronidazole against clostridium perfringens, propionibacterium acnes, and anaerobic gram-positive cocci. | using an agar dilution method, we determined the in vitro activity of oritavancin, vancomycin, clindamycin and metronidazole against 114 unique clinical isolates of gram-positive anaerobes. mic(90)s (microg/ml) for oritavancin were as follows: clostridium perfringens 1.0, propionibacterium acnes 0.25, peptostreptococcus anaerobius 0.25, peptoniphilus asaccharolyticus 0.5, finegoldia magna 0.25, micromonas. micros 0.25, and anaerococcus prevotii 0.25. on a weight basis, oritavancin is slightly mo ... | 2005 | 16701537 |
| genetic basis of resistance in propionibacterium acnes strains isolated from diverse types of infection in different european countries. | the purpose of the study was to characterize the resistance mechanism of 36 clindamycin (cl) and erythromycin (em) resistant propionibacterium acnes strains and 27 tetracycline (tet) resistant p. acnes isolates, collected from nine european countries, both from acne patients and from patients with different infections. pcr and sequencing of the genes encoding domain v of 23s rrna for cl and em resistant strains and 16s rrna for tet resistant strains were performed. pulsed-field gel electrophores ... | 2005 | 16701544 |
| endogenous endophthalmitis by propionibacterium acnes associated with leflunomide and adalimumab therapy. | to report a case of unusual endogenous endophthalmitis associated with the use of leflunomide and adalimumab. | 2006 | 16703558 |
| a multicenter efficacy and tolerability evaluation of benzoyl peroxide in a 10% urea vehicle for the treatment of acne vulgaris. | acne vulgaris is a common skin disease that affects 70 to 96% of individuals. topical benzoyl peroxide has been used successfully for acne treatment; however, it may be accompanied by drying and or flaking skin. the addition of a 10% urea to the product excipient is theorized to moisturize the skin due to its humectant properties, aid in the efficacy of benzoyl peroxide due to its keratolytic properties, and effectively combat propionibacterium acnes due to its antibacterial properties. | 2006 | 16703780 |
| elimination and multiplication of bacteria during preparation and storage of buffy coat-derived platelet concentrates. | the prevalence of bacterial contamination of random-donor platelet concentrates (pcs) is considerably lower than that of blood donations. which key steps of the preparation procedure contribute to the elimination of bacteria was investigated. | 2006 | 16734811 |
| role of intravitreal triamcinolone acetonide in the treatment of postoperative endophthalmitis. | to report the use of commercially available triamcinolone acetonide as adjunct treatment for acute-onset endophthalmitis after intraocular procedures. | 2006 | 16770261 |
| [biotyping of propionibacterium acnes strains isolated from patients with acne vulgaris]. | propionibacterium acnes is the main bacterial etiologic agent in acne vulgaris pathogenesis. the rate of antibiotic resistant p. acnes isolates is less than 10% in our country. the aim of this study was to biotype p. acnes strains which were isolated from acne vulgaris patients and to investigate the biotype distribution in our region. p. acnes isolates from 64 patients (18 male, 46 female; mean age 19 +/- 3.1 years) were included in the study and biotyped by sugar-specific ph changes using sorb ... | 2006 | 16775952 |
| inhibitors of dipeptidyl peptidase iv and aminopeptidase n target major pathogenetic steps in acne initiation. | acne is a chronic disease hallmarked by sebaceous hyperplasia, follicular hyperkeratosis, and inflammation. parallel targeting of these factors is required to treat acne effectively. inhibitors of dipeptidyl peptidase iv (dp iv) and aminopeptidase n (apn) show strong anti-inflammatory effects on immune cells and therapeutic efficacy in autoimmune disorders. our investigation focused on the expression and functional relevance of these ectopeptidases in three cell types which exhibit an altered ph ... | 2007 | 16778789 |
| effect of bacteriocin produced by lactococcus sp. hy 449 on skin-inflammatory bacteria. | this study was carried out to evaluate the effect of bacteriocin produced by lactococcus sp. hy 449 against skin-inflammatory bacteria such as staphylococcus epidermidis atcc 12228, staphylococcus aureus atcc 65389, streptococcus pyogenes atcc 21059, and propionibacterium acnes atcc 6919. the spot-on-the-lawn method was used to determine the antimicrobial activity of bacteriocin against indicator strains on the human skin. the bacteriocin produced by lactococcus sp. hy 449 inhibited the growth o ... | 2006 | 16793484 |
| propionibacterium acnes and lipopolysaccharide induce the expression of antimicrobial peptides and proinflammatory cytokines/chemokines in human sebocytes. | acne is a common skin disorder of the pilosebaceous unit. in addition to genetic, hormonal and environmental factors, abnormal colonization by propionibacterium acnes has been implicated in the occurrence of acne via the induction of inflammatory mediators. to gain more insight into the role that sebocytes play in the innate immune response of the skin, particularly in acne, we compared the antimicrobial peptide and proinflammatory cytokine/chemokine expression at mrna and protein levels, as wel ... | 2006 | 16797202 |
| infections associated with orthopedic implants. | we review recent advances in the prevention, diagnosis and treatment of infections associated with joint prostheses and internal fixation devices. | 2006 | 16804382 |
| revision shoulder arthroplasty with positive intraoperative cultures: the value of preoperative studies and intraoperative histology. | currently, there are no reported results of patients without overt infection who had a positive intraoperative culture during revision shoulder arthroplasty. we therefore reviewed the intraoperative and preoperative investigations as well as the postoperative course of these patients who had positive intraoperative cultures. we reviewed the results of 75 shoulders without overt infection that underwent revision shoulder arthroplasty at our institution between january 1, 1974 and december 31, 200 ... | 2006 | 16831641 |
| influence of skin flora and preventive measures on surgical site infection during cardiac surgery. | the skin flora responsible for most surgical site infections (ssis) include staphylococcus aureus, coagulase-negative staphylococci, propionibacterium acnes, gram-negative bacilli, micrococci, and diphtheroids. the two major methods of reducing local concentrations of bacteria are administration of an antibiotic and cleansing of the skin. resistance to antibiotics is a major concern. mortality rates in patients infected by methicillin-resistant staphylococcus aureus or comparably virulent bacter ... | 2006 | 16834542 |
| development and application of multiplex polymerase chain reaction for the etiological diagnosis of infectious endophthalmitis. | uniplex polymerase chain reaction (pcr) for detection of bacterial and panfungal genome has been applied onto a large number of intraocular fluids facilitating management of infective endophthalmitis. | 2006 | 16855317 |
| genome sequence of propionibacterium acnes reveals immunogenic and surface-associated genes confirming existence of the acne biofilm. | 2006 | 16863535 | |
| [suppurative hepatic lesion with extension to soft tissues]. | 2006 | 16863627 | |
| anti-inflammatory properties of narrow-band blue light. | narrow-band blue light (420 nm) has demonstrated safety and efficacy in the treatment of acne vulgaris. it works by exhibiting a phototoxic effect on the heme metabolism of propionibacterium acnes. previous studies using blue light showed more improvement in inflammatory lesions than in comedones, as well as some improvement on the untreated side. cytokines have demonstrated a critical role in the development of inflammation. the expression of pro-inflammatory cytokines such as il-1alpha have be ... | 2006 | 16865864 |
| an in vitro study of antimicrobial activity and efficacy of iodine-generating hydrogel dressings. | to determine the antimicrobial activity and efficacy of different formulations of novel bioxygenating hydrogel dressings (which deliver both iodine and oxygen into the wound) against various target organisms by means of an in vitro test system that more effectively mimics the conditions encountered when dressings are in contact with wounds. | 2006 | 16869198 |
| in vitro activities of daptomycin, vancomycin, and penicillin against clostridium difficile, c. perfringens, finegoldia magna, and propionibacterium acnes. | daptomycin has in vitro activity against gram-positive anaerobic bacteria, although limited numbers of species have been tested. we studied the in vitro activities of daptomycin, vancomycin, and penicillin against more than 100 strains each of clostridium difficile, c. perfringens, finegoldia magna, and propionibacterium acnes. daptomycin etest mics and results from time-kill studies were determined for selected strains. for 392 of 421 strains (93%), daptomycin was inhibitory at < or =1 microg/m ... | 2006 | 16870765 |
| the mechanisms of action of nicotinamide and zinc in inflammatory skin disease. | nicotinamide (niacinamide), a physiologically active form of niacin (nicotinic acid), in combination with zinc is being assessed in clinical studies for the treatment of inflammatory skin diseases such as acne vulgaris and bullous pemphigoid. the basis for these investigations is the variety of potential mechanisms of action of nicotinamide and zinc, including an anti-inflammatory effect via inhibition of leukocyte chemotaxis, lysosomal enzyme release, lymphocytic transformation, mast cell degra ... | 2006 | 16871773 |
| in vivo porphyrin production by p. acnes in untreated acne patients and its modulation by acne treatment. | propionibacterium acnes is often discussed as a contributing pathogenic factor in the aetiology of acne lesions. the aim of this study was to test which porphyrin patterns are synthesized by p. acnes in vivo in untreated acne patients and during standard acne regimens. these photosensitive compounds are potential targets for photo-dynamic therapy of acne and need to be better characterized in the skin. using high-performance liquid chromatography coproporphyrin iii was the main porphyrin identif ... | 2006 | 16874416 |
| polymerase chain reaction-based identification of propionibacterium acnes types isolated from the male urinary tract: evaluation of adolescents, normal adults and men with prostatic pathology. | to assess whether colonization of the male urinary tract with propionibacterium acnes, in particular types ib and ii (which are associated with inflammation in radical prostatectomy specimens and might be involved in the development of prostate cancer), is associated with prostate disease, and thus to develop a urine test to detect men at risk of prostate disease. | 2006 | 16879683 |
| [the effect of preoperative topical antibiotics in cataract surgery]. | we studied whether topical antibiotics prevent endophthalmitis after cataract surgery. | 2006 | 16884070 |
| isolation of propionibacterium acnes from central nervous system infections. | propionibacterium acnes is a common skin colonizer and its involvement in central nervous system (cns) infections may be related with previous neurosurgical procedures. p. acnes was isolated in pure or mixed cultures from ten patients with cns infections during a 5-year period. the clinical presentation, treatment and outcome were retrospectively reviewed. nine out of 11 patients had cns infections after a neurosurgical procedure. the clinical presentation was: brain abscess (five patients), sub ... | 1995 | 16887502 |
| ribotyping of bacteria from root canal and blood of patients receiving endodontic therapy. | dna restriction patterns and corresponding ribotypes of 26 bacterial isolates (propionibacterium acnes, peptostreptococcus prevotii, fusobacterium nucleatum, prevotella intermedia, prevotella nigrescens, actinomyces israelii, streptococcus intermedius, and streptococcus sanguis) recovered from patients with infected root canals and their peripheral blood, collected during and after endodontic therapy, were examined. eleven additional reference strains including type strains were also examined. p ... | 1997 | 16887597 |
| identification of propionibacterium acnes by polymerase chain reaction for amplification of 16s ribosomal rna and lipase genes. | propionibacterium acnes belongs to the cutaneous flora and is present in sebaceous follicles. the fatty acids that are released from sebum triglycerides by the action of this bacterial lipase play an important role in the pathogenesis of acne vulgaris. p. acnes is also involved in postoperative disorders and opportunistic infections in immunosuppressed hosts. recently, it has been proposed that p. acnes causes sarcoidosis. therefore, rapid isolation and identification of p. acnes is important. t ... | 2003 | 16887681 |
| acne: more than skin deep. | acne is one of the most prevalent skin conditions affecting teenagers. it is a disease of the pilosebaceous unit. blockage of sebaceous glands and colonisation with proionobacterium acnes leads to acne. grading the severity of acne helps to determine the appropriate treatment. treatment of acne should be started as early as possible to minimise the risk of scarring and adverse psychological effects. it should be tailored to the individual patient, the type of acne, its severity, the patient's ab ... | 2006 | 16891439 |