Publications

primary structure and anticandidal activity of the major histatin from parotid secretion of the subhuman primate, macaca fascicularis.	a major macaque histatin (m-histatin 1) from the parotid secretion of the subhuman primate, macaca fascicularis, was isolated by gel filtration on bio-gel p-2 and purified to homogeneity by reversed-phase high-performance liquid chromatography on a tsk-ods c18 column. the complete amino acid sequence of m-histatin 1, determined by automated edman degradation, is: (formula; see text) m-histatin 1 contains 38 amino acid residues, a phosphoserine at residue 2, has a molecular weight of 4881.8, a ca ...	1990	2229609
diagnostic issues in depression in old age.		1997	2230068
diffuse axonal injury: analysis of 100 patients with radiological signs.	one hundred patients with head injuries who showed diffuse axonal injury on computed tomographic scans are reported. evaluation of the glasgow coma score, pupillary signs, and computed tomographic findings on admission led to an improved ability to forecast outcomes. our relatively good results as compared with other series, can be explained by the high proportion of children and by the liberal use of computed tomography to evaluate head injuries, thus revealing that concussion may sometimes be ...	2008	2234337
prediction of outcome of shunt procedures for communicating hydrocephalus.		2008	2234351
effect of the standard on size of the horizontal-vertical illusion.	70 subjects participated in a study designed to replicate the 1968 claim of gardner and long that the horizontal-vertical illusion is larger with the vertical than with the horizontal as standard. the effect did not appear in exp. 1 when subjects made judgments under both the reproduction and graded-series methods but did in a pilot study and in exp. 2, although more strongly with the method of reproduction.	1987	2235250
[urinary symptoms in elderly women in nursing homes. frequency and social consequences of urinary incontinence in elderly women living in nursing homes].	all 278 female residents of nursing homes in the county of roskilde were assessed as regards the extent and severity of urinary incontinence and possible urinary infections. a total of 168 (58.5%) were incontinent. culture of the urine was performed in 210 women and significant bacteriuria was demonstrated in 50%. thirty-four out of the total of 287 women (12%) had indwelling catheters. in incontinent women without catheters, great quantities of urine were often voided involuntarily. despite thi ...	2007	2238207
[urinary symptoms in elderly women in nursing homes. frequency and social consequences of urinary incontinence in elderly women living in nursing homes].	all 278 female residents of nursing homes in the county of roskilde were assessed as regards the extent and severity of urinary incontinence and possible urinary infections. a total of 168 (58.5%) were incontinent. culture of the urine was performed in 210 women and significant bacteriuria was demonstrated in 50%. thirty-four out of the total of 287 women (12%) had indwelling catheters. in incontinent women without catheters, great quantities of urine were often voided involuntarily. despite thi ...	2007	2238207
the practice of neurology.		2007	2241611
inhibition of interleukin-2-induced tumor necrosis factor release by dexamethasone: prevention of an acquired neutrophil chemotaxis defect and differential suppression of interleukin-2-associated side effects.	high concentrations of tumor necrosis factor (tnf) alpha have been detected in the plasma of patients undergoing immunotherapy with interleukin 2 (il-2), suggesting that this cytokine may play a role in the fever and shocklike state induced by the administration of high-dose il-2. dexamethasone has been shown to inhibit the synthesis of tnf by monocytes activated in vitro by endotoxin. to determine if dexamethasone can exert a similar suppressive effect on il-2-induced tnf synthesis in vivo, the ...	2006	2242421
a review of parachuting injuries.		2006	2242920
segmental vascular resistance in postobstructive pulmonary vasculopathy.	chronic unilateral pulmonary arterial ligation has been touted as a model of arteriopathy resulting in a tremendous increase in anastomotic bronchial flow (qbr) via collaterals. to investigate its effects on the pulmonary vasculature, we ligated the left main pulmonary artery of seven dogs and 120 days later pump perfused their left lower lobes (lll) via a cannula in the pulmonary artery at pulmonary arterial flow (qpa) of 250 ml/min. we measured qbr (330 ml/min) and compared lll with control co ...	1990	2246149
the endocrinology of parturition in the human.	current evidence suggests that oestrogens, progesterone, relaxin, the prostaglandins, and oxytocin are all hormones concerned to a major degree with the onset and maintenance of parturition. oestrogens, relaxin, and the prostaglandins are particularly involved with cervical ripening, while prostaglandins, progesterone and oxytocin are more involved in regulating myometrial contractility. catecholamines may also have some regulatory function in relation to uterine contractions. progesterone domin ...	1990	2248599
use of gore-tex (polytetrafluoroethylene) in the anophthalmic socket.	the gore-tex soft tissue patch is composed of large open spaces surrounded by polytetrafluoroethylene (ptfe) fibers connected to nodules of solid ptfe. it was used in 12 oculoplastic surgery patients. primary and secondary spherical silicone implants were wrapped with a gore-tex patch and implanted into tenon's capsule. this study reports our first results using this versatile material.	2007	2248727
mandatory hiv testing in critical care/emergency patients.	testing for the presence of the human immunodeficiency virus (hiv) remains one of the most controversial issues of this decade. among persons diagnosed to be hiv positive, social ostracism and exaggerated atypical behavior are common. the resulting impact on the delivery of healthcare services to the seropositive patient has raised many ethical and professional dilemmas. discussion of hiv testing and the subsequent effects of seropositivity on the delivery of healthcare will be emphasized.	1990	2249461
characterization of a cdna encoding for the 28.5-kda lhcii apoprotein from the unicellular marine chlorophyte, dunaliella tertiolecta.	three distinct clones, encoding light-harvesting chlorophyll (lhcii) proteins associated with photosystem ii were isolated from a cdna library of the unicellular marine chlorophyte, dunaliella tertiolecta. we determined the nucleotide sequence of one of these clones, as well as the n-terminal amino acid (aa) sequences of the four mature lhcii apoproteins (24.5, 28.5, 30 and 31 kda). the sequenced cdna clone encoded the precursor of the 28.5-kda apoprotein. we deduced that the transit peptide is ...	2006	2249775
[bacillary dysentery--1988].		1990	2251385
[a new serotype of shigella boydii].	two strains which belong to the same serotype of shigella were isolated from the bloody-pus stool of two patients (in 1986) and is reported in this paper. the results were identical both showing agglutination in low titer with serotype 8 of s. dysenteriae and serotype 4 of s. boydii when the two strains were checked well with all kinds of diagnostic antisera and vice versa, ie the antisera produced by the two strains were also checked well with sera prepared with the representative strains of al ...	1990	2251827
morphine attenuation of a conditioned emotional response in post-dependent rats.	rats placed in a test chamber where they had received repetitive shocks the previous day significantly reduced their motor activity; this was taken as indicator of a conditioned emotional response. morphine attenuated this conditioned suppression of motility, possibly due to a reduction of the anxiety associated with the expectation of the noxious stimuli. previous morphine dependence (20 mg/kg daily for 26 days) did not modify the effect of the opioid on the conditioned suppression of motility. ...	1990	2253691
[successful therapy of ph1 positive chronic myelocytic leukemia with oral form of etoposide].	a 33-year-old female was diagnosed as having chronic myelocytic leukemia (cml) with philadelphia (ph1) chromosome and breakpoint cluster region (bcr) rearrangement. physical examination revealed a huge splenomegaly and laboratory data showed wbc 490 x 10(3)/microliter and nap score 44. she was treated with hydroxyurea, alpha-interferon, or busulfan, but severe adverse reaction such as skin rash, fever, and arthralgia, which allowed the therapy discontinue was occurred. when the patient was treat ...	2007	2255067
a comparative clinical trial of duodenal ulcer healing with two regimens of cimetidine: 800 mg once nightly and 400 mg twice daily.	the efficacy and safety of two dosage regimens of cimetidine were compared in a single-blind study of 50 adults with endoscopically proven duodenal ulcers. patients were randomly allocated to receive 800 mg cimetidine taken once nightly or 400 mg cimetidine taken twice daily for 4 weeks. following 4 weeks' treatment patients again underwent endoscopy and, if healing was incomplete, they received a further 4 weeks' treatment. at 4 weeks, healing occurred in 21/25 (84%) patients on the once-daily ...	2008	2257964
lymphoid dendritic accessory cells of the rat.	the expression of mhc class ii antigens on potential apc is a crucial step in t-lymphocyte activation and the initiation of an immune response. the studies which are presented here were initiated to characterize the critical apc present in physiologically normal, untreated rats. such a cell should constitutively express these antigens at high density and therefore provide the apparatus necessary to provoke both primary and secondary immune responses at any time. dac were found to fulfill these c ...	1990	2258188
from theory to practice: the planned treatment of drug users. interview by stanley einstein.		2008	2258262
[scanning laser ophthalmoscopy. its value in macular diseases].	the scanning laser ophthalmoscope provided a high quality television image of the fundus with minimal illumination of the retina. this new device based on a totally new electro-optical principle allowed a detailed exploration of macular function directly under simultaneous fundus control. the focused beam of a yellow krypton laser (568,2 nm) was swept up and down, rights and links across the fundus to form a raster of parallel lines on the retina. the s.l.o. illuminated only a single retinal poi ...	2007	2258548
[scanning laser ophthalmoscopy. its value in macular diseases].	the scanning laser ophthalmoscope provided a high quality television image of the fundus with minimal illumination of the retina. this new device based on a totally new electro-optical principle allowed a detailed exploration of macular function directly under simultaneous fundus control. the focused beam of a yellow krypton laser (568,2 nm) was swept up and down, rights and links across the fundus to form a raster of parallel lines on the retina. the s.l.o. illuminated only a single retinal poi ...	2007	2258548
non-aids-associated kaposi's sarcoma (classical and endemic african types): treatment with low doses of recombinant interferon-alpha.	in the treatment of the classical and endemic african forms of kaposi's sarcoma (ks), radiation therapy and chemotherapy have been widely used with varying degrees of success and morbidity. we here report our preliminary experiences with low doses of recombinant interferon alfa-2b (rifn alpha-2b) in the treatment of these types of ks, non-linked to the acquired immunodeficiency syndrome (aids). ten consecutive patients (eight patients with classical and two with endemic ks) with a median age of ...	2008	2258634
interferons and collagen production.	the immunoregulatory, antiviral, and antiproliferative agents known as the interferons have profound effects on collagen synthesis. interferons alpha, beta, and gamma suppress collagen synthesis by dermal fibroblasts. in addition, interferon gamma (ifn-gamma) inhibits the constitutively increased collagen synthesis characteristic of fibroblasts derived from lesions of patients with scleroderma. ifn-gamma also inhibits collagen synthesis by myofibroblasts and synovial fibroblast-like cells. inhib ...	1990	2258640
induction from a single instance: formation of a novel category.	this study examines whether preschoolers can use information from a known category to induce a characteristic attribute of a novel, contrasting category based on a single instance. we showed 32 four-year-olds three instances of a given category and one instance of a target category. these objects could vary along two attribute dimensions, such as color and shape. all instances of the given category shared identical values of one attribute (e.g., all were blue), but could have different values of ...	2007	2258687
induction from a single instance: formation of a novel category.	this study examines whether preschoolers can use information from a known category to induce a characteristic attribute of a novel, contrasting category based on a single instance. we showed 32 four-year-olds three instances of a given category and one instance of a target category. these objects could vary along two attribute dimensions, such as color and shape. all instances of the given category shared identical values of one attribute (e.g., all were blue), but could have different values of ...	2007	2258687
anterior chamber depth with sulcus and capsular bag placed iogel lenses.	the anterior chamber depth was measured in 15 eyes with sulcus placed (group 1) and 12 eyes with bag placed (group 2) iogel pc-12 lenses, and in 11 eyes with bag placed iogel 1103 lenses (group 3). the mean anterior chamber depth was 3.29 mm in group 1, 4.17 mm in group 2, and 4.16 mm in group 3. the difference between the mean anterior chamber depth with sulcus and bag placed iogel pc-12 lenses is statistically significant (p less than .0005). one effect of the different anterior chamber depths ...	2008	2258810
arab medicine.		2008	2258852
training in infectious diseases.		2008	2258855
[bacteriology and epidemiology of shigellas isolated at the army hospital in djibouti].	in a space of 26 months 108 shigellas were isolated from 104 patients with sporadic and benign diseases. 90% of the subjects were young french. both s. dysenteriae and s. boydii make up 21% of the strains studied. 13% of the germs are multiresistance. multiresistance can enhance development of serious sickness if a virulent strain comes in.	1990	2263188
the use of knee braces during rehabilitation.	this article has profiled the use of knee braces as an augmentation to the overall rehabilitation program following knee injury. it has also outlined other aspects of rehabilitation, the use of continuous passive motion devices, and other forms of exercises and training that, together with bracing, may enhance patient recovery. continuous passive motion devices have been used for many different orthopedic problems with good success. understanding the mechanics of how these devices move the knee ...	2008	2265438
effects of maternal cigarette smoking on ultrasonic measurements of fetal growth and on doppler flow velocity waveforms.	serial ultrasound biometry and doppler flow velocity waveform analysis were used to measure the effects of maternal smoking in a prospective study of 535 pregnancies. smoking was associated with significant reductions in maternal weight gain, birthweights and placental weights. decreased fetal biparietal diameter measurements were observed in pregnancies of smoking women; this effect was maximal at 24 weeks' gestation, was restricted to male fetuses and was not associated with altered head circu ...	2007	2265596
effects of maternal cigarette smoking on ultrasonic measurements of fetal growth and on doppler flow velocity waveforms.	serial ultrasound biometry and doppler flow velocity waveform analysis were used to measure the effects of maternal smoking in a prospective study of 535 pregnancies. smoking was associated with significant reductions in maternal weight gain, birthweights and placental weights. decreased fetal biparietal diameter measurements were observed in pregnancies of smoking women; this effect was maximal at 24 weeks' gestation, was restricted to male fetuses and was not associated with altered head circu ...	2007	2265596
control of choroidal blood flow by the nucleus of edinger-westphal in pigeons: a laser doppler study.	anatomical studies in birds have suggested that choroidal blood flow may be regulated by a circuit involving the following serially-connected components: the retina-the suprachiasmatic nucleus (scn)-the medial subdivision of the nucleus of edinger-westphal (mew)-the ciliary ganglion-the choroidal blood vessels. in order to better clarify the role of this circuit, we examined the effects of electrical stimulation of ew on choroidal blood flow in the ipsilateral eye, using laser doppler velocimetr ...	1990	2265988
effects of dialysis membranes on beta 2-microglobulin production and cellular expression.	we investigated the effects of different dialysis membranes on the production of beta 2-microglobulin (beta 2m) in peripheral blood mononuclear cell cultures (pbmnc) obtained from hemodialysis patients in a prospective cross-over design study. chronic dialysis with cuprophane membrane leads to an increase in beta 2m production from 129 +/- 11 ng/ml to 192 +/- 23 ng/ml (p less than 0.002). this increase is reversed by the use of a non-complement activating membrane polymethylmethacrylate. in addi ...	2007	2266681
effects of dialysis membranes on beta 2-microglobulin production and cellular expression.	we investigated the effects of different dialysis membranes on the production of beta 2-microglobulin (beta 2m) in peripheral blood mononuclear cell cultures (pbmnc) obtained from hemodialysis patients in a prospective cross-over design study. chronic dialysis with cuprophane membrane leads to an increase in beta 2m production from 129 +/- 11 ng/ml to 192 +/- 23 ng/ml (p less than 0.002). this increase is reversed by the use of a non-complement activating membrane polymethylmethacrylate. in addi ...	2007	2266681
hepatic antipyrine metabolism in athletes.	the aim of the present study was to investigate the influence of prolonged physical exercise on hepatic metabolism. an oral antipyrine loading test (15 mg/kg body weight) was carried out on 24 healthy male subjects: 8 controls, 8 sprinters (anaerobic activity), 8 long distance runners (aerobic activity). antipyrine clearance resulted to be significantly higher in athletes vs. controls, without a significant difference between the two groups of athletes. these results put forward the importance o ...	2008	2266756
localized in vivo proton spectroscopy of the bone marrow in patients with leukemia.	volume selective magnetic resonance (mr) proton spectroscopy was used to investigate the haemopoietic (iliac bone) and fatty bone marrow (tibia) in patients with leukemia and polycythaemia vera. selective measurements of the relaxation times t1 and t2 for the "water" and "fat" resonances in the bone marrow spectra were performed. nine patients with acute leukemia and three patients with chronic leukemia were examined at diagnosis. three patients with acute leukemia in remission were also examine ...	2008	2266805
construction of an auxotrophic shigella flexneri strain for use as a live vaccine.	a virulent shigella flexneri serotype y strain, sfl1, was made auxotrophic for aromatic metabolites, including p-aminobenzoic acid, which is not available in mammalian tissues, by transduction of a tn10-inactivated arod gene from escherichia coli k-12 nk5131. one transductant, sfl114, selected for further studies, had the same biochemical and serological characteristics as the parent strain and the o-antigen patterns of the two strains were identical in sds-page and western blot experiments. sfl ...	1990	2266855
animal models of drug self-administration by smoking.		2008	2267011
chorionic villus sampling for prenatal diagnosis in wales using dna probes--5 years' experience.	chorionic villi were sampled from 125 women who requested prenatal diagnosis, either for genetic disorder or because of advanced maternal age. of these, 105 samples were obtained by the transcervical route and 20 were obtained by the transabdominal approach. the sampling success rate was 97 per cent (122/125). the mean maternal age of the patients was 31 years (range 17-44) and the mean gestational age at which the chorionic villus sampling was performed was 10 weeks (range 7-13 weeks). seventy- ...	2007	2267238
[diagnostic imaging of pulmonary emphysema. from radiography to high-resolution computerized tomography].		2008	2267388
[school and occupational achievement of children and adolescents with epilepsy].		2008	2267818
herniation of rae tube through split boyle davis gag.		2007	2268034
herniation of rae tube through split boyle davis gag.		2007	2268034
the preferential uptake of very-low-density lipoprotein cholesteryl ester by rat liver in vivo.	the removal from the blood and the uptake by the liver of injected very-low-density lipoprotein (vldl) preparations that had been radiolabelled in their apoprotein and cholesteryl ester moieties was studied in lactating rats. radiolabelled cholesteryl ester was removed from the blood and taken up by the liver more rapidly than sucrose-radiolabelled apoprotein. near-maximum cholesteryl ester uptake by the liver occurred within 5 min of the injection of the vldl. at this time, apoprotein b uptake ...	1990	2268298
definition of the transcription initiation site of human plasminogen gene in liver and non hepatic cell lines.	we have mapped the cap site of the human plasminogen mrna by primer extension and pcr techniques and found that it is located at position -161 relative to the first atg, 97 bases upstream to the 5' end of the previously isolated cdna clone. seven human hepatic and non hepatic cell lines and fresh liver cells were tested for human plasminogen mrna expression: the liver and the liver derived hepg2 cell line represent the major site of plasminogen rna synthesis while the other cell lines (hep3b, he ...	1990	2268308
use of a spread sheet to calculate the current-density distribution produced in human and rat models by low-frequency electric fields.	the current-density distribution produced inside irregularly shaped, homogeneous human and rat models by low-frequency electric fields is obtained by a two-stage finite-difference procedure. in the first stage the model is assumed to be equipotential. laplace's equation is solved by iteration in the external region to obtain the capacitive-current densities at the model's surface elements. these values then provide the boundary conditions for the second-stage relaxation solution, which yields th ...	1990	2268377
functional and nmr studies of hb sassari (asp-126 alpha----his); role of the inter-subunit contacts in the affinity control of human hemoglobin.	the oxygen affinity of hemoglobin sassari (asp-126 alpha----his), a variant substituted in the alpha 1 beta 1 interface, was found to be 8-times greater relative to normal adult human hemoglobin. study of the exchangeable hydrogen-bonded protons by nmr spectroscopy shows only minor changes at the alpha 1 beta 1 interface. in particular, the resonance previously assigned to the proton of the hydrogen bond asp-126 alpha 1. . . tyr-35 beta 1 in normal hemoglobin is still present in the variant spec ...	1990	2268670
structural aspects of pathology in alzheimer's disease.	the characteristic lesions of alzheimer's disease, neurofibrillary tangles and neuritic plaques, are the sites of accumulation of abnormal fibrillar material. the structure of the paired helical filament from tangles has been analysed by electron microscopy and biochemical studies have shown that it contains microtubule associated protein tau as a component. fibrils of beta-amyloid in the neuritic plaque arise by polymerization of a small proteolytic fragment of a much larger precursor protein. ...	2008	2268679
[extrahepatic biliary tract atresia and a common biliopancreatic canal. review of the literature apropos of a case].	the authors report the case of an 3 months old caucasian boy which had an extrahepatic biliary atresia associate with a congenital biliary cyst and an anomalous pancreaticobiliary junction. the patency between gallbladder and duodenum permits the operative opacification of this long common pancreaticobiliary channel. the congenital biliary cyst was located on the upper part of the common bile duct and was obstructed by biliary concretions. unfortunately, no patency between intrahepatic bile duct ...	2008	2268955
monocytic leukemoid reaction, glucocorticoid therapy, and myelodysplastic syndrome.	a leukemoid reaction is a complex and poorly understood response by the bone marrow to a variety of stresses; although any peripheral blood cell line may be involved, it is rarely a purely monocytic event. a case is reported of a true monocytic leukemoid reaction in a patient with myelodysplastic syndrome related to the effect of corticosteroids on the underlying marrow disorder.	2008	2268969
effects of stimulus level on forward-masked psychophysical tuning curves in quiet and in noise.	forward-masked psychophysical tuning curves were obtained from normal-hearing listeners at different probe levels in quiet and in a broadband background noise. in quiet, tuning-curve shape changed with probe level. for six listeners, tuning curves became broader with increasing probe level, primarily due to a decrease in the low-frequency slopes. for one listener, tuning curves became narrower with increasing probe level. the addition of a background noise, which was presented continuously at a ...	2006	2269730
survey of enteropathogenic agents in children with and without diarrhoea in ghana.	a survey was carried out over 1 year in a rural area of ghana on the isolation, detection and/or identification of enteric pathogens from children under 5 years of age with and without diarrhoea. the isolation and detection rate of shigella flexneri, shigella dysenteriae, giardia lamblia and rotavirus were higher in children with diarrhoea than in controls. yersinia enterocolitica, vibrio cholerae and vibrio parahaemolyticus were not isolated during the period of this survey. the incidence of ot ...	1990	2270006
[acute rhabdomyolysis. a study of 44 cases].	fourty four patients suffering non traumatic rhabdomyolysis (rm) are studied. the most frequently encountered etiologies were neurologic abnormalities in 26 patients, followed by infections in 7 patients and metabolic abnormalities in four cases. eleven patients (25%) presented several associated factors. the clinical manifestations of rm were not very significant, with only 18% of patients presenting muscle pain, 38.6% proteinuria and 36.4% hematuria. a significant increase in k, cpk, ldh, and ...	2008	2270337
effects of tokishakuyakusan and keishibukuryogan on steroidogenesis by rat preovulatory follicles in vivo.	the effect of tokishakuyakusan (ts) and keishibukuryogan (kb) on estradiol-17 beta, progesterone and testosterone in serum and ovarian tissue from pms-treated immature rats was examined in vivo. the in vivo intravenous administration of 20 micrograms of ts or kb increased the concentrations of estradiol-17 beta, progesterone and testosterone. these results suggest that ts and kb stimulate in vivo the production of estradiol-17 beta, progesterone and testosterone by preovulatory follicles, and th ...	1990	2270849
a comparison of dilevalol and placebo in the management of isolated systolic hypertension using ambulatory monitoring.	1. the antihypertensive effect of dilevalol, a compound which combines beta-adrenoceptor blocking and vasodilating properties due to beta 2-adrenoceptor agonism, was studied in nineteen patients with isolated systolic hypertension (ish). a randomized, double-blind, placebo-controlled, cross-over trial with two 4 week treatment periods was used to compare the efficacy of once daily dosing with dilevalol (in the range of 100-400 mg daily) against placebo. assessment of response involved both casua ...	2008	2271366
independent eye movements in the turtle.	in order to evaluate the normal eye movements of the turtle, pseudemys scripta elegans, the positions of each eye were recorded simultaneously using two search-coil contact lenses. optokinetic nystagmus (okn) was strikingly unyoked in this animal such that one eye's slow-phase velocity was substantially independent of that of the other eye. on the other hand, the fast-phase motions of both eyes occurred more or less in synchrony. an eye's slow-phase gain is primarily dependent on the direction a ...	1994	2271458
induction of g.c to a.t transitions by the acridine half-mustard icr-191 supports a mispairing mechanism for mutagenesis by some bulky mutagens.	as the most nucleophilic atom in dna, the guanine n7 atom is a major site of attack for a large number of chemical mutagens as well as chemotherapeutic agents. paradoxically, while methylation of guanine n7 is believed to be largely nonmutagenic, aflatoxin b1, among the most potent mutagens, appears to exert its mutagenic activity through adduction at this site. on the basis of an analysis of the specificity of mutations induced by various adduct forms of aflatoxin b1, we have previously propose ...	1990	2271689
antithrombotic therapy for coronary artery disease and valvular heart disease.		1990	2271788
toxic dilatation of the colon in shigellosis.		1990	2271862
[health care and the church].		1991	2272079
shigellosis in new brunswick.		1990	2272103
[histologic grade, dna content and image analysis in soft tissue tumors].	flow cytometry and image analysis technique were used to quantitate the nuclei of various soft tissue tumors. a single representing section from soft tissue sarcoma was used for histologic grading. histologic and cytometric comparative analyses showed that all 21 benign tumors were diploid. among 62 cases of soft tissue sarcoma, 45 (73%) were aneuploid. there was a significant difference in the nuclear area between benign and malignant tumors (p less than 0.01), diploid and aneuploid tumors (p l ...	1993	2272261
dna sequence analysis of the reca genes from proteus vulgaris, erwinia carotovora, shigella flexneri and escherichia coli b/r.	the complete nucleotide sequences of the reca genes from escherichia coli b/r, shigella flexneri, erwinia carotovora and proteus vulgaris were determined. the dna sequence of the coding region of the e. coli b/r gene contained a single nucleotide change compared with the e. coli k12 gene sequence whereas the s. flexneri gene differed at 7 residues. in both cases, the predicted proteins were identical in primary structure to the e. coli k12 reca protein. the dna sequences of the reca genes from e ...	1990	2274037
[role of protons and bicarbonate in adaptative gastric cytoprotection].	the unknown mechanism of adaptative gastric cytoprotection (agc) induced by 20% ethanol and subsequent injury with 70% ethanol was studied in wistar rats. pretreatment with indomethacin or hgii2 did not prevent the agc, there suggesting that neither endogenous pgs nor gastric mucus take part in its mechanism. on the other hand, ranitidine pretreatment blocked and even aggravated the damage induced by ethanol-ethanol. in contrast, the latter phenomenon was reverted by 20% acidified ethanol. it is ...	1990	2275313
antenatal diagnosis of parenti-fraccaro type achondrogenesis.		2008	2276781
protective milk o antibodies induced in guinea pigs by parenteral shigella ribosomal vaccine.	igg and iga o antibodies were studied in milk and sera of guinea pigs subcutaneously immunized at various stages of pregnancy with shigella ribosomal vaccines (srv) from shigella sonnei and shigella flexneri. both vaccines induced o antibodies in milk, the level of iga antibodies being significantly higher than that of igg antibodies. the immune milk provided a clear-cut protection against experimental shigella-induced keratoconjunctivitis. these results are consistent with the previously shown ...	1990	2276843
prolongation of anesthesia with xylazine, ketamine, and guaifenesin in horses: 64 cases (1986-1989).	on 74 occasions, 54 horses and 6 foals were anesthetized with xylazine and ketamine or xylazine, guaifenesin, and ketamine, with or without butorphanol. on 64 occasions, anesthesia was prolonged for up to 70 minutes (34 +/- 15 min) by administration of 1 to 9 supplemental iv injections of xylazine and ketamine at approximately a third the initial dosage. all horses except 5 were positioned in lateral recumbency, and oxygen was insufflated. in adult horses, the time from induction of anesthesia t ...	2008	2276967
extra-amniotic pregnancy. a trip to the extraembryonic coelom.		2008	2277404
bone allografts sterilised by irradiation. biological properties, procurement and results of 150 massive allografts.	massive bone allografts from cadavers have been sterilised by gamma-radiation from radioactive cobalt at a dose of 25,000 gray (gy). the biological effects of radiation are discussed. human cortical bone showed an acceptable 20% decrease in strength on bending tests after 27,000 gy irradiation, but higher doses are more damaging and should be avoided. the procurement protocol used at the cochin hospital is described, and the importance of dosimetry and record-keeping emphasised. the clinical res ...	1990	2279829
an experience with diagnostic paracentesis in 100 cases of acute abdomen.	prognosis of acute surgical conditions of abdomen of both traumatic and non-traumatic origin depends on accurate diagnosis and early surgical intervention. however, the diagnosis in acute abdomen is quite difficult. the problem becomes more complex when 24 hours services of radiology and laboratories are not available. abdominal tap gives a valuable clue to diagnosis. a 10 ml syringe fitted with a 20 gauge intravenous needle was used for the purpose. both the flanks and the four quadrants of the ...	2007	2280070
[current views on the pathomorphology and pathogenesis of dysentery].	according to the literature and the authors' data in patients who died of dysentery shigellae are found seldom because of postmortem shedding of superficial colonic epithelium infected by them. shigella adhesion and invasion into the colonocytes are regularly found in the colon biopsies. as shown recently in experiments, shigella outer membrane proteins forming "contact haemolysin" ("virulence plasmid" product) are responsible for their invasion. in the small intestine this cytotoxin is destroye ...	1990	2281980
[the characteristics of the proliferative processes in the epithelium of the sigmoid intestine in acute bacillary dysentery].	proliferative processes were studied using radioautography with 3h-thymidine at the height of the disease and in the early convalescence of the bacterial dysentery. the mucous membrane of the sigmoid colon of healthy persons undergoing rectoromanoscopy due to the epidemic reasons served as control. no pathologic changes were found in these healthy persons; the labeled nuclei index (lni) was 5.75 +/- 0.4%, the label intensity (li) characterizing the rate of dna synthesis was 14.9 +/- 0.8. during ...	1990	2285363
[the epidemiological characteristics of shigellosis].		1990	2286252
antigenic and catalytic disparity in the distribution of cytochrome p-450-dependent 25-hydroxyvitamin d3-1 alpha- and 24-hydroxylases.	chick 25-hydroxyvitamin d3-1 alpha-hydroxylase, a cytochrome p-450 monooxygenase with a molecular weight of 57 kda, can be isolated as described by mandel et al. (1990 b). under normal physiological circumstances, it occurs exclusively in kidney mitochondria. an isozyme of the 1 alpha-hydroxylase, known as the 24-hydroxylase, which uses the same substrate to yield an isomeric product, is also a cytochrome p-450 monooxygenase, has a molecular weight of 55 kda, and like-wise occurs in kidney mitoc ...	1990	2286531
problem with the use of total distance travelled and average speed as measures of postural sway.		2008	2287187
american medical association white paper on elderly health. report of the council on scientific affairs.		2008	2288622
[the differential diagnosis of intestinal amebiasis].	differential diagnosis of intestinal amebiasis (106 patients), acute flexner's dysentery (105 patients) and nonspecific ulcerative colitis (31 patients) based on the clinical data and rectoromanoscopic findings is described. rapidly and gradually progressing in the first 7 days intestinal amebiasis is characterized by a gradual onset, normal t0 with mounting general weakness, celiectasia, diarrhea with hyaloid mucus, focal catarrh-hemorrhagic changes and appearance of individual oval transversal ...	1990	2290391
association of thrombotic thrombocytopenic purpura and human immunodeficiency virus infection.	a 35 year-old hiv-positive male intravenous drug abuser developed thrombotic thrombocytopenic purpura (ttp) during the course of recto-sigmoiditis secondary to shigella flexneri. complete remission was achieved by aggressive treatment of a combination of plasma exchange, fresh frozen plasma infusion, continuous prostacyclin perfusion, p.o. administered aspirin-dipyridamol and intravenous injections of vincristine. during acute microangiopathy, an acquired type ii von willebrand disease was diagn ...	1990	2290713
intracellular lytic enzyme systems and their use for disruption of escherichia coli.	this article focusses on lytic enzyme systems available in e. coli and their potential use for cellular disruption. in the systems described here the genetic information for lysis would be carried within the microbial host, either integrated or naturally occurring on chromosomal dna, or on extrachromosomal elements such as plasmids. each microbe would carry complete information for endogenous enzymatic lysis, and lysis would occur in a controlled manner after being triggered by an external facto ...	1990	2291440
changes in the antibiotic sensitivities of urinary pathogens, 1971-1989.	all urinary pathogens from general practice and hospital have been tested for sensitivity to a range of antimicrobial agents for the last 19 years. there have been marked changes during that time. in general practice there has been a considerable increase in the proportion of staphylococcal infections from 5.1% to a peak of 14.8% in 1982 and a more recent decline to 3.4%. there has also been a decrease in the proportion caused by proteus mirabilis, from 9.2% to 5.0%. similar, but smaller changes ...	1990	2292543
production of propeptide-directed antibody: its application to the purification of proalbumin and analysis of proalbumin processing.	antibodies which specifically recognize rat proalbumin, but not mature serum-albumin, were raised. propeptide (nh2-arg-gly-val-phe-arg-arg) with an additional cysteine residue at the carboxyl terminus was conjugated to ovalbumin through either sulfide or amino group and the conjugates were injected into rabbits. monospecific antibodies were purified on a propeptide-coupled affinity column and further immobilized as an affinity support, allowing us to purify proalbumin in a single step from rat l ...	1990	2292582
a sensitive in vitro functional assay to detect k(+)-channel-dependent vasodilators.	this study describes a sensitive in vitro relaxation assay using isolated rabbit mesenteric artery to detect the activity of a vasodilator as a k(+)-channel activator. thus, comparison of several known k(+)-channel activators was made with other vasodilators known to work via various cellular mechanisms. the vasodilators used were minoxidil sulfate (mnxs; 5 microm), brl-34915 (cromakalim, 0.1 microm), nicorandil (10 microm), pinacidil (1 microm), diazoxide (100 microm), sodium nitroprusside (10 ...	1990	2292878
evaluation of combined effects in dose-response studies by statistical comparison with additive and independent interactions.	an improved method for the evaluation of combined drug effects by means of dose-response curves (drcs) is described. a drug, a, was tested in the absence and presence of a fixed concentration of another drug, b, mainly in organ-bath experiments with smooth muscle strips from bovine coronary arteries and tracheal muscle. the results of such experiments are expressed in terms of percent of maximum response. median values, rather than mean values, for each concentration of drug a were determined in ...	1990	2292882
metabolism of retinoic acid and retinol by intact cells and cell extracts.		2008	2292968
in vitro skin absorption and metabolism of benzoic acid, p-aminobenzoic acid, and benzocaine in the hairless guinea pig.	the percutaneous absorption and metabolism of three structurally related compounds, benzoic acid, p-aminobenzoic acid (paba), and ethyl aminobenzoate (benzocaine), were determined in vitro through hairless guinea pig skin. benzocaine was also studied in human skin. absorption of benzocaine was rapid and similar through both viable and nonviable skin. the absorption of the two acidic compounds, benzoic acid and paba, was greater through nonviable skin. a small portion (6.9%) of absorbed benzoic a ...	1990	2293213
release of human serum albumin from poly(lactide-co-glycolide) microspheres.	human serum albumin (hsa) was encapsulated in a 50:50 copolymer of dl-lactide/glycolide in the form of microspheres. these microspheres were used as a model formulation to study the feasibility of controlling the release of large proteins over a 20- to 30-day period. we show that hsa can be successfully incorporated into microspheres and released intact from these microspheres into various buffer systems at 37 degrees c. a continuous release of the protein could be achieved in physiological buff ...	1990	2293220
effects of a diluent on the retarded-release property of acrylate methacrylate--salicylic acid coacervates.		2007	2293223
effects of a diluent on the retarded-release property of acrylate methacrylate--salicylic acid coacervates.		2007	2293223
production of specific monoclonal antibodies to salmonella typhi flagellin and possible application to immunodiagnosis of typhoid fever.	four murine monoclonal antibodies (mabs) to salmonella typhi flagellin were produced. these mabs did not react with eight other enterobacterial strains tested: salmonella enteritidis, salmonella typhimurium, salmonella paratyphi a, escherichia coli, shigella flexneri, shigella sonnei, yersinia enterocolitica, and campylobacter jejuni. all four mabs cross-reacted with salmonella muenchen flagellin indicating specificity for d antigenic flagellar epitope. one mab (c4) was selected to develop a dou ...	1990	2295860
investigation by amperometric methods of intracellular reduction of 2,6-dichlorophenolindophenol in normal and transformed hepatocytes in the presence of different inhibitors of cellular metabolism.	the reduction of 2,6-dichlorophenolindophenol (dcip) was measured by amperometric methods in morris hepatoma 3924a cells, normal isolated rat hepatocytes and in mitochondria isolated from normal rat liver. the influence of aerobic and anaerobic atmospheres and of various inhibitors of cellular metabolism, especially of the respiratory chain (kcn, nan3, oligomycin), on dcip-reduction were studied using glucose, succinate, beta-hydroxybutyrate, alpha-keto-glutarate and oxalacetate as substrates. u ...	1990	2297512
virg, an agrobacterium tumefaciens transcriptional activator, initiates translation at a uug codon and is a sequence-specific dna-binding protein.	the agrobacterium tumefaciens ti plasmid virg locus, in conjunction with vira and acetosyringone, activates transcription of the virulence (vir) genes. insertional and deoxyoligonucleotide-directed mutagenesis studies showed that both octopine and nopaline ti plasmid virg genes initiate translation at a uug codon. virg protein initiated at this uug codon was found to be 241 amino acid residues in length and had an apparent molecular mass of 27.1 kilodaltons. a salmonella typhimurium trp-virg tra ...	1990	2307647
usefulness of rapid production model for pancreatic carcinoma in male hamsters.	the rapid production model of pancreatic duct adenocarcinoma established previously in female syrian hamsters was applied to male hamsters to confirm the efficacy of the "augmentation pressure" procedure and to reveal sex difference in response to this procedure. hamsters received 70 mg/kg n-nitrosobis (2-oxopropyl) amine (bop) as an initiation and two cycles of "augmentation pressure" consisting of ethionine on a choline-deficient diet, methionine and bop and an additional 20 mg/kg bop and were ...	1990	2317782
32p-postlabeling assay for carcinogen-dna adducts: description of beta shielding apparatus and semi-automatic spotting and washing devices that facilitate the handling of multiple samples.	the utilization of the 32p-postlabeling assay in combination with tlc for the sensitive detection and estimation of aromatic dna adducts has been increasing in the past few years. the procedure consists of 32p-labeling of carcinogen-adducted 3'-nucleotides in the dna digests using [gamma-32p]atp and polynucleotide kinase, separation of 32p-labeled adducts by tlc, and their detection by autoradiography. during both 32p-labeling and initial phases of tlc, a relatively high amount of [gamma-32p]atp ...	2008	2323007
contact sensitization to diazolidinyl urea: report of 3 cases.		2008	2323203
a prospective cohort study on the development of colorectal cancer after gastrectomy.	a prospective cohort study was conducted to examine whether an association exists between gastric surgery and the subsequent development of colorectal carcinoma. one thousand nine hundred twenty-seven patients (1316 men and 611 women) who had undergone curative gastrectomy for gastroduodenal diseases in the first department of surgery, tottori university hospital, during the 18-year period from 1964 to 1981, were followed to determine the incidence of the development of large-bowel carcinoma aft ...	2008	2323279
ca2+ transients are not required as signals for long-term neurite outgrowth from cultured sympathetic neurons.	a method for clamping cytosolic free ca2+ ([ca2+]i) in cultures of rat sympathetic neurons at or below resting levels for several days was devised to determine whether ca2+ signals are required for neurite outgrowth from neurons that depend on nerve growth factor (ngf) for their growth and survival. to control [ca2+]i, normal ca2+ influx was eliminated by titration of extracellular ca2+ with egta and reinstated through voltage-sensitive ca2+ channels. the rate of neurite outgrowth and the number ...	1990	2324199