Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| the role of the local immune response in the pathogenesis of peptic ulcer formation. | mucosal immune responses are designed to provide local protection against infection, without inducing excessive amounts of inflammation that would alter epithelial integrity or function. it has become clear that the epithelium not only serves as a barrier to exclude pathogens, but also initiates host responses to infection. gastric epithelial cells infected with helicobacter pylori can respond within hours to produce inflammatory mediators that recruit and activate neutrophils. the gastric epith ... | 1994 | 7863238 |
| the role of omeprazole and antibiotic combinations in the eradication of helicobacter pylori--an update. | when omeprazole is given with an appropriate antibiotic, a high rate of helicobacter pylori eradication can be achieved. to date, most studies have used omeprazole and amoxycillin, and an analysis of the results suggests that, at present, the most effective treatment regimen comprises omeprazole, 20 mg twice daily, and amoxycillin, 1 g twice daily, for 14 days. this regimen provides an eradication rate of about 85%. results using omeprazole plus bismuth or tetracycline have been disappointing; h ... | 1994 | 7863239 |
| long-term consequences of helicobacter pylori eradication. | long-term infection with helicobacter pylori could potentially lead to asymptomatic chronic gastritis, chronic dyspepsia, duodenal ulcer disease, gastric ulcer disease, or gastric malignancy, including both adenocarcinoma and b-cell lymphoma. currently, the two most important indications for eradication of this bacterium are proven h. pylori-associated duodenal or gastric ulcer disease. many studies have shown that successful eradication of h. pylori dramatically reduces the rate of duodenal ulc ... | 1994 | 7863240 |
| treatment strategies for symptom resolution, healing, and helicobacter pylori eradication in duodenal ulcer patients. | the introduction of anti-helicobacter pylori therapy has increased the number of options available for the management of patients with duodenal ulcer disease. the aim of this paper is to summarize current knowledge and use it to form a strategy relevant to the management of patients with duodenal ulcer disease. four key aspects are addressed. (i) selection of duodenal ulcer patients for anti-h. pylori treatment. as the subgroup of patients who will develop minor disease activity in the future ca ... | 1994 | 7863241 |
| future research in peptic ulcer disease. | for the past 10 years, research into peptic ulcer disease has focused on the surprising suggestion that gastritis and peptic ulcers may be caused by the bacterium helicobacter pylori. however, the time has now come to reappraise research directions, as a causal link has been established, and even the most ardent sceptics now accept that h. pylori infection is the major factor in most cases of peptic ulcer disease. as with any established microbial disease, we need to understand the epidemiology ... | 1994 | 7863242 |
| helicobacter pylori eradication: the rational treatment for peptic ulcer disease--chairmen's conclusion. | 1994 | 7863243 | |
| are there susceptible hosts to helicobacter pylori infection? | susceptibility to helicobacter pylori infection may manifest itself as an increased prevalence of h. pylori infection, as reinfection after eradication, or as different clinical outcomes (gastritis, peptic ulcer disease, primary gastric b-cell lymphoma, or gastric cancer). these outcomes are likely to be a result of interaction between environmental and genetic factors. genetic factors include both host genetic predisposition to infection as well as genetic differences in h. pylori strains. twin ... | 1994 | 7863244 |
| effect of nizatidine versus ranitidine on gastric intraluminal prostaglandin release in duodenal ulcer patients. | the role of prostaglandins in peptic ulcer disease and their relation to helicobacter pylori infection remain controversial. this study sought to compare the effects of oral nizatidine and ranitidine on the gastric mucosal release of prostanoids in duodenal ulcer (du) patients and to correlate prostanoid concentrations with h. pylori status. twenty-eight patients with dus were randomized to receive either nizatidine or ranitidine. nizatidine 300 mg at night elevated intraluminal pge2 concentrati ... | 1994 | 7863255 |
| [helicobacter pylori infection in gastric lymphoma]. | 1995 | 7863427 | |
| the effect of eradication of helicobacter pylori upon the duodenal ulcer recurrence--a 24 month follow-up study. | to evaluate the effect of eradication of helicobacter pylori(h.pylori) in the patients with duodenal ulcer(du) upon the du recurrence. | 1994 | 7865492 |
| scintigraphic assessment of the intragastric distribution and gastric emptying of an encapsulated drug: the effect of feeding and of a proton pump inhibitor. | local delivery of therapeutic agents to the stomach may be a useful strategy in the treatment of helicobacter pylori infection. we aimed to see whether the intragastric distribution and gastric retention of a therapeutic agent could be improved, either by giving omeprazole or by dosing after a meal. | 1994 | 7865640 |
| amoxycillin capsules with omeprazole for the eradication of helicobacter pylori. assessment of the importance of antibiotic dose timing in relation to meals. | giving antibiotics after meals prolongs their gastric residence time and improves their intragastric distribution. we aimed to see whether this would result in improved eradication of helicobacter pylori. | 1994 | 7865641 |
| [preliminary screening of chinese herbal medicine in inhibiting helicobacter pylori]. | at present helicobacter pylori (hp) was taken to be closely related to chronic atrophic gastritis and peptic ulcer. 226 patients with symptoms of upper digestive tract by endoscope were examined and chronic atrophic gastritis and peptic ulcer were diagnosed. mucous membrane from gastric antrum was taken and cultured, and found that 136 cases of 226 patients were hp positive and the rate of positiveness was 60.18%. 200 kinds of chinese herbal medicine were selected to investigate its inhibitory a ... | 1994 | 7866001 |
| conservation of the cytotoxin-associated (caga) gene of helicobacter pylori and investigation of association with vacuolating-cytotoxin activity and gastroduodenal disease. | polymerase chain reaction (pcr) amplification and dna hybridization analyses were used to test for the presence of the cytotoxin-associated (caga) gene in 108 strains of helicobacter pylori. fifty-two geographically diverse strains of known vacuolating cytotoxin activity, and 56 recent uk clinical isolates from patients with duodenal ulceration (n = 28) and from healthy individuals who were endoscopically normal (n = 28) were studied. overall, caga was detected by pcr in 74 (69%) strains and dna ... | 1994 | 7866352 |
| peptic ulcer disease in adolescence: changing concepts in the age of helicobacter pylori. | 1994 | 7866738 | |
| one-week low-dose triple therapy: new standards for helicobacter pylori treatment. | 1995 | 7866804 | |
| seroprevalence of helicobacter pylori in residents of a hospital for people with severe learning difficulties. | to assess the seroprevalence of helicobacter pylori among the residents of a hospital for people with severe learning difficulties. | 1995 | 7866805 |
| one-week low-dose triple therapy for the eradication of helicobacter pylori infection. | to evaluate the efficacy and safety of two 1-week low-dose triple therapy regimens for the treatment of helicobacter pylori infection. | 1995 | 7866820 |
| [helicobacter pylori in the dental plaque]. | helicobacter pylori (hp) were detected in the dental plaque in 40 patients with peptic ulcer, chronic gastritis or gastric cancer with rapid urease test, anti-hp fluorescein-labelled antibody staining, bacterial culture and electronic microscopy. at the same time, biopsy specimens from the gastric antrum of these patients were studied with ws staining and rapid urease test to detect hp. the results show that a great lot of hps is present in most of the patients' dental plaque. the morphological, ... | 1994 | 7867441 |
| [helicobacter pylori infection and stomach lymphoma]. | 1995 | 7867490 | |
| helicobacter pylori-specific cd4+ t-cell clones from peripheral blood and gastric biopsies. | colonization of human gastric mucosa with cytotoxic strains of the bacterium helicobacter pylori is associated with peptic ulcer and with chronic gastritis. since little is known about the t-cell response to h. pylori, we investigated the cd4+ t-cell response both in peripheral blood mononuclear cells (pbmcs) and at the site of infection. first, we compared the bulk pbmc proliferative response to the bacterium in individuals with and without symptoms of gastroduodenal disease. we found that the ... | 1995 | 7868233 |
| helicobacter pylori in normal gastric mucosa. | since the discovery of helicobacter pylori (h. pylori) in 1983 several studies have established relationship of h. pylori with gastritis, duodenal ulcer disease and gastric carcinoma. h. pylori infection is widely prevalent and exposure occurs at younger age in our country. several western studies have shown prevalence of h. pylori in normal gastric mucosa to range from 0-25%. as similar information is not available from our country we estimated the prevalence of h. pylori in histologically norm ... | 1994 | 7868485 |
| flagellin gene profiling of helicobacter pylori infecting symptomatic and asymptomatic individuals. | diversity within and around the flagellin (fla) a gene of helicobacter pylori was studied by polymerase chain reaction/restriction fragment length polymorphism (pcr/rflp) analysis and genomic southern blot hybridization profiling. four distinct pattern types were identified by ddei restriction analysis of the 1.5-kb flaa amplicon of 55 strains. most strains (73%) had the same flaa rflp type, but subtypic variation was evident in some strains. no consistent associations were observed for selected ... | 1994 | 7871237 |
| the novel anti-ulcer agent ecabet sodium (ta-2711) eradicates helicobacter pylori colonizing on the gastric mucosa of japanese monkeys. | 1994 | 7871373 | |
| positive correlation between h,k-adenosine triphosphatase autoantibodies and helicobacter pylori antibodies in patients with pernicious anemia. | helicobacter pylori is a major cause of gastritis, and the parietal cell h,k-adenosine triphosphatase (atpase) is a major autoantigen in autoimmune atrophic corpus gastritis, which may eventually lead to pernicious anemia and/or neuropathy. whether the bacterium induces the autoimmune response is unknown. | 1994 | 7871374 |
| effects of omeprazole and eradication of helicobacter pylori on gastric and duodenal mucosal enzyme activities and dna in duodenal ulcer patients. | duodenal and gastric content of mucosal enzymes in duodenal ulcer (du) patients differs from that of controls. the purpose of this study has been to examine the effect of omeprazole and eradication of helicobacter pylori on mucosal enzymes in du patients. | 1994 | 7871380 |
| clinically feasible stable isotope technique at a reasonable price: analysis of 13co2/12co2-abundance in breath samples with a new isotope selective-nondispersive infrared spectrometer. | up to now, stable isotope analysis of carbon dioxide in breath samples is carried out with sensitive but very expensive and complex isotope ratio mass spectrometry (irms). aiming at a more widespread application of breath tests in gastroenterological diagnostic routine, we tested a newly developed isotope selective non-dispersive infrared spectrometer (ndirs) in comparison to irms. 13c-urea breath tests were performed in 63 patients as the routine screening method for helicobacter pylori infecti ... | 1994 | 7871857 |
| [low malignancy malt lymphoma of the stomach: h. pyloric eradication as a therapeutic concept?]. | a 63 year old patient came to admission because of abdominal pain. a stone disease of the gallbladder was known. gastroscopy showed active gastritis of the antral-mucosa with some erosive lesions. histology revealed surprisingly a low grade malt lymphoma. helicobacter pylori colonization (h. pylori) was found in the mucosa. while additional lymphomas were not found, a therapy aiming at the eradication of h. pylori was started. a subsequent control biopsy showed only slight lymphoplasmacellular i ... | 1994 | 7871859 |
| azithromycin triple therapy for helicobacter pylori infection: azithromycin, tetracycline, and bismuth. | azithromycin is new acid-stable macrolide that achieves 10- to 40-fold higher tissue levels than erythromycin after oral dosing. important to note, the tissue half-life of azithromycin is measured in days instead of hours. | 1995 | 7872278 |
| effects of helicobacter pylori infection on healing and recurrence of gastric ulcers. | the effects of helicobacter pylori infection on the healing and recurrence of gastric ulcers were investigated. | 1995 | 7872279 |
| gastrospirillum hominis ("helicobacter heilmanii"): a cause of gastritis, sometimes transient, better diagnosed by touch cytology? | besides helicobacter pylori, another spirillar microorganism, provisionally called gastrospirillum hominis, has been described in the human stomach in association with gastritis. the aim of this study was to assess the role of cytology in the diagnosis, to assess the gastritis associated with this infection, and to approach its natural history. | 1995 | 7872280 |
| eradication of helicobacter pylori may not reverse severe gastric dysplasia. | 1995 | 7872296 | |
| primary and acquired resistance to clarithromycin among helicobacter pylori strains in malaysia. | 1995 | 7872306 | |
| low dose clarithromycin plus omeprazole eradicates helicobacter pylori in duodenal ulcer disease. | 1995 | 7872307 | |
| inhibition of helicobacter pylori urease activity by hydroxamic acid derivatives. | helicobacter pylori (hp) produces strong urease [ec 3.5.1.5], which is considered to play a role in the pathogenesis of gastritis and peptic ulcers. inhibitions against this enzyme have been studied with hydroxamic acid (hxa) derivatives of aliphatic or aromatic carboxylic acids, amino acids and dipeptides. a number of hxas potently inhibited the urease (i50 values were near the order of 10(-6)m), and h-ile-gly-nhoh (i50 = 0.20 x 10(-6)m) was the most potent inhibitor among the derivatives. hp u ... | 1994 | 7874052 |
| [sensitivity of gastric parietal cells to histamine after administration of enprostil and ranitidine during 4 weeks in healthy subjects]. | parietal cell sensitivity is increased in patients with active duodenal ulcer. it has been shown to increase in healthy volunteers after a 4-week treatment with h2-receptor blockers. metaanalyses of therapeutic trials have indicated that time to first relapse was longer after ulcer healing with prostaglandins (pg) than after healing with h2-receptor blockers, which might be due to a different effect of the two treatments on parietal cell sensitivity. objectives--to study, in healthy volunteers, ... | 1994 | 7875435 |
| lymphocytic gastritis, gastric adenocarcinoma, and primary gastric lymphoma. | a series of primary gastric lymphomas and adenocarcinomas was reviewed to assess the prevalence of lymphocytic gastritis in these conditions. lymphocytic gastritis was more prevalent in patients with gastric adenocarcinoma (16 of 130 cases; 12.3%) and primary gastric lymphoma (six of 45 cases; 13.7%) than in unselected patients undergoing endoscopy (0.83-2.5%). this suggests that these two disparate gastric tumours may share an immunological dysfunction or a common pathogenesis, and this is of i ... | 1994 | 7876391 |
| treatment for helicobacter pylori infection. | 1994 | 7876524 | |
| the prevalence of helicobacter pylori positivity in human immunodeficiency virus-infected children. | to investigate the prevalence of helicobacter pylori infection in pediatric patients infected with the human immunodeficiency virus, we sought to detect the presence of antibodies against this organism in 23 human immunodeficiency virus-infected children of central african ethnic origin by means of a second-generation enzyme-linked immunoassay (elisa) test for the detection of immunoglobulin g (igg) antibodies to helicobacter pylori (malakit helicobacter pylori, biolab, limal, belgium). they wer ... | 1994 | 7876996 |
| [bleeding peptic ulcers--how can recurrent bleeding be prevented?]. | bleeding is the most frequent complication of peptic ulcer disease. patients with a previous ulcer hemorrhage have a high risk for future bleeding episodes. therefore, treatment aiming at ulcer prophylaxis is mandatory. helicobacter pylori infection, acid/pepsin and intake of aspirin or nsaids are the main causal factors involved in the pathogenesis of peptic ulcer disease. ulcers induced by nonsteroidal anti-inflammatory drugs can be cured by gastric acid suppression (e.g. omeprazole) and preve ... | 1995 | 7877428 |
| expression of a human alpha-1,3/4-fucosyltransferase in the pit cell lineage of fvb/n mouse stomach results in production of leb-containing glycoconjugates: a potential transgenic mouse model for studying helicobacter pylori infection. | helicobacter pylori is a human pathogen associated with the development of gastric and duodenal ulcers and gastric adenocarcinoma. to test the hypothesis that the human lewis(b) blood group antigen (le(b)) functions as a receptor for the bacteria's adhesins and mediates its attachment to gastric pit and surface mucous cells, a human alpha-1,3/4-fucosyltransferase was expressed in these cell lineages in fvb/n transgenic mice. the fucosyltransferase directed production of the leb epitope without a ... | 1995 | 7878011 |
| [helicobacter pylori in patients with gastroduodenal pathology at a young age]. | 1994 | 7879558 | |
| helicobacter pylori infection in children with recurrent abdominal pain. | forty-eight patients with recurrent abdominal pain were studied endoscopically for the presence of gastritis and helicobacter pylori infection. fifteen of these children had histological evidence of gastritis with eight of them having concomitant h. pylori infection. the majority of those with h. pylori infection had severe degrees of acute following chronic gastritis. | 1994 | 7880086 |
| how helicobacter pylori acquired its name, and how it overcomes gastric defence mechanisms. | at royal perth hospital, western australia in april 1982, spiral bacteria were first cultured from a gastric biopsy specimen. several important taxonomic features were identified which indicated that these bacteria represented a new genus. in october 1989 the new genus name helicobacter was published. helicobacter pylori overcomes gastric defence mechanisms by means of its powerful urease enzyme, by its spiral shape allowing it to penetrate mucus, by adherence to the gastric mucosa and by variou ... | 1994 | 7881010 |
| gastric mucosal defensive factors: the therapeutic strategy. | there are several interesting approaches to augmenting defence or repair mechanisms that can be used already or may find a place in therapy for ulcer disease. factors such as epidermal growth factor and basic fibroblast growth factor show potential. alternative strategies might be to stimulate mucosal blood flow with agents that release nitric oxide (no), or to scavenge free radicals in the inflamed or ischaemic mucosa. if such approaches are to find a role in therapy, it is likely that it will ... | 1994 | 7881011 |
| the therapeutic strategy for peptic ulcer disease. | therapy of acid/peptic disease has evolved since the 1970s with development of: (i) more accurate endoscopes which permit precise examination and documentation of upper gastrointestinal lesions; and (ii) the histamine h2-receptor antagonists. as well, refined standards for clinical investigation have contributed to the clinical study of acid/peptide diseases. initially, ulcer diseases were considered to be principally secondary to increased 'aggressive' factors (acid, pepsin) and the therapeutic ... | 1994 | 7881012 |
| effect of ammonium ion on the hydrophobic and barrier properties of the gastric mucus gel layer: implications on the role of ammonium in h. pylori-induced gastritis. | infection with the bacterium helicobacter pylori is associated with both the development of gastritis and an attenuation in the hydrophobic properties of the stomach. in order to better understand the effect of ammonium, one of the major products of h. pylori urease on these properties, a series of in vivo and in vitro experiments was performed. in the in vivo studies rats were intragastrically administered nh4cl alone and in combination with the mucolytic agent, muco-mist, in various dosing str ... | 1994 | 7881013 |
| helicobacter pylori epidemiology in relation to peptic ulcer and gastric cancer in south and north china. | peptic ulcer disease is twice as common in people living in south china when compared with those in north china. however, the gastric cancer rate in north china is three times that of south china. the overall helicobacter pylori prevalence rate is similar in north and south china populations and it is higher than caucasians living in western societies. however, there is a significantly higher prevalence of h. pylori seropositivity among those who live in the high gastric cancer areas of china. o ... | 1994 | 7881017 |
| how does helicobacter pylori cause duodenal ulcer disease: the bug, the host, or both? | helicobacter pylori infection is the most common cause of duodenal ulcer disease, yet duodenal ulcer is an uncommon outcome of h. pylori infection. we reviewed the possible explanations such as differences in the host or in the strain of h. pylori. host factors reviewed included genetic susceptibility to h. pylori infection and excess gastric acid secretion. the role of potential h. pylori virulence factors not present in all strains such as the caga gene and the results of other molecular metho ... | 1994 | 7881025 |
| aetiological factors of peptic ulcer: perspectives of epidemiological observations this century. | there are five known environmental, causative factors for peptic ulcer, namely, non-steroidal anti-inflammatory drugs (nsaid), helicobacter pylori infection, cigarette smoking, environmental stress and dietary habit. there have been six factual, epidemiological observations on peptic ulcer this century: the rise and fall of ulcer frequency in western societies; geographical variations in ulcer rates; in sex ratios; in duodenal: gastric ulcer ratios; and in placebo healing rates; and seasonal var ... | 1994 | 7881028 |
| clinical relevance of basic research in peptic ulcer disease. | historically, the interplay between basic research and clinical observation has been essential in the development of new therapies for peptic ulcer disease. that histamine is an important regulator of acid secretion emerged from basic research, followed by the clinical development and use of the h2-receptor antagonists. basic research contributed again by defining the importance of h+/k(+)-atpase in acid secretion, resulting in a new class of useful antisecretory agents. basic studies also gave ... | 1994 | 7881029 |
| identification of four new prokaryotic bacterioferritins, from helicobacter pylori, anabaena variabilis, bacillus subtilis and treponema pallidum, by analysis of gene sequences. | the nucleotide (nt) sequence of the helicobacter pylori (hp) napa gene, encoding neutrophil-activating protein a (hpnap) was determined. alignment of this sequence with those of known bacterioferritins (bfr) revealed sequence homology and conservation of a 7-amino-acid (aa) motif constituting the ferroxidase (frx) center of bfr in the hpnap. the n-terminal aa sequence deduced from the iron-regulated mrgc gene of bacillus subtilis [chen et al., j. bacteriol. 175 (1993) 5428-5437] is highly simila ... | 1995 | 7883175 |
| effect of helicobacter pylori eradication on gastric metaplasia of the duodenum. | helicobacter pylori associated duodenal ulcers occur in patches of gastric metaplasia. the pathogenesis of gastric metaplasia is unclear, but it has been produced in experimental animals by acute injury and has been shown to be present to a greater extent of h pylori positive subjects. this study aimed to discover if gastric metaplasia regressed with eradication of h pylori or healing of duodenal ulcers, or both. thirty two duodenal ulcer patients with h pylori infection confirmed by biopsy urea ... | 1995 | 7883216 |
| helicobacter pylori associated with a high prevalence of duodenal ulcer disease and a low prevalence of gastric cancer in a developing nation. | this study examines the relationship between helicobacter pylori infection and peptic ulcer disease and gastric cancer--in particular, the presence or absence of bacteria, the grading of gastritis, and the degree of inflammation in the antral and oxyntic mucosae. the grading of gastritis and the detection of h pylori were determined by histology using the sydney system. of the 1006 patients examined, 34.5% had duodenal ulcer disease, 3.5% gastric ulcer disease, and 2% with coexistent ulceration. ... | 1995 | 7883217 |
| helicobacter pylori in dental plaque of children and their family members. | a prospective study was undertaken to determine the presence of helicobacter pylori in the dental plaque of children and their family members. 22 children (age range: 2-12 years; males: 16) admitted to the paediatric ward for various disorders and 17 healthy family members (age range: 7-40 years; males: 9) of 13 of these children were screened for presence of helicobacter pylori in the dental plaque by the rapid urease test. h. pylori was detected in dental plaque of 82% (18/22) children and 88% ... | 1994 | 7883668 |
| transportation of helicobacter pylori cultures by optimal systems. | cultures of helicobacter pylori on chocolate agar slants in bijou bottles and on chocolate agar plates inside bbl campy pouches were mailed from dublin to galway, ireland; bordeaux, france; and beijing, china. both systems maintained viability of h. pylori for at least 4 days under mailing conditions. ninety percent of the isolates on the slants survived for 6 days, but only 30% of the isolates in the pouches survived. when the slants were stored at 4 degrees c after arrival, 50% of the isolates ... | 1994 | 7883907 |
| triple therapy eradicated h. pylori equally in patients pretreated with omeprazole or ranitidine. a 12-month follow-up. | the aim of this study was twofold: first, to investigate the effectiveness of a standard triple therapy (tripotassium dicitrato bismuthate, 125 mg q.i.d., tetracycline hydrochloride 500 mg q.i.d., and metronidazole 500 mg t.i.d.) in eradicating helicobacter pylori in patients with duodenal ulcer successfully healed with omeprazole or ranitidine; second, to examine the influence of the eradication on duodenal ulcer recurrence rate after 12 months. two hundred forty-five consecutive h. pylori-posi ... | 1995 | 7884169 |
| [predictive value of latex agglutination on helicobacter pylori in children with recurrent abdominal pain]. | in a prospective investigation, a rapid latex test for helicobacter pylori in the serum (pyloriset) was carried out in 39 patients with recurrent abdominal pain aged from six to 15 years. the test was positive in 19 patients. all of these children were subjected to gastroduodenoscopy. seven cases showed a helicobacter-associated chronic active antrum gastritis, whereas in the remaining 12 children gastritis not induced by helicobacter or normal mucosa was found. of the 20 pyloriset-negative pati ... | 1995 | 7885020 |
| genetic abnormalities during transition from helicobacter-pylori-associated gastritis to low-grade maltoma. | 1995 | 7885139 | |
| micronutrients and cancer aetiology: the epidemiological evidence. | micronutrient deficiencies occur most commonly in poor countries and, therefore, are most likely to be associated with cancers common in these countries. epidemiological studies are hampered by inaccurate measurement of micronutrient intake and by the correlations between intakes of many nutrients. the strongest evidence for a protective effect of micronutrients is for oesophageal cancer. the identity of the micronutrients is not certain, but may include retinol, riboflavin, ascorbic acid and zn ... | 1994 | 7886059 |
| effects of omeprazole and lansoprazole on 24-hour intragastric ph in helicobacter pylori-positive volunteers. | the comparative effects of omeprazole and lansoprazole on gastric acidity in helicobacter pylori-positive subjects and the clearance of h. pylori are unknown. | 1994 | 7886393 |
| omeprazole plus amoxicillin for cure of helicobacter pylori infection. factors influencing the treatment success. | omeprazole plus amoxicillin may cure helicobacter pylori infection. however, the published results vary rather widely, and the factors influencing the treatment success remain unclear. | 1994 | 7886394 |
| development of a mouse model of helicobacter pylori infection that mimics human disease. | the human pathogen helicobacter pylori is associated with gastritis, peptic ulcer disease, and gastric cancer. the pathogenesis of h. pylori infection in vivo was studied by adapting fresh clinical isolates of bacteria to colonize the stomachs of mice. a gastric pathology resembling human disease was observed in infections with cytotoxin-producing strains but not with noncytotoxic strains. oral immunization with purified h. pylori antigens protected mice from bacterial infection. this mouse mode ... | 1995 | 7886456 |
| ranitidine bismuth citrate and ranitidine do not affect gastric emptying of a radio-labelled liquid meal. | ranitidine bismuth citrate, a new chemical entity which is a salt complex of ranitidine and bismuth citrate, is being developed for the treatment of relapse of benign gastric and duodenal ulcer and eradication of helicobacter pylori. the aim of the present study was to establish whether ranitidine bismuth citrate (800 mg) or ranitidine hydrochloride (300 mg) have any effect on gastric emptying of a liquid meal using gamma scintigraphy. on three separate occasions, each of twelve subjects receive ... | 1994 | 7888296 |
| eradication of helicobacter pylori in management of peptic ulceration. evidence supports eradication only in patients who have helicobacter and peptic ulceration. | 1995 | 7888909 | |
| mucosal iga antibody against helicobacter pylori in chronic gastritis and intestinal metaplasia detected by the tes-tape method in resection specimens after gastrectomy for gastric cancer. | subjects with atrophic body gastritis have a high prevalence of helicobacter pylori seropositivity and a low prevalence of h. pylori infection. disappearance of the organism appears to correlate with the development of intestinal metaplasia. to investigate this point, intestinal metaplasia was biochemically subclassified into complete and incomplete types by the tes-tape method, and tissue iga and igg antibodies against h. pylori were measured by enzyme-linked immunosorbent assay (elisa). | 1995 | 7889477 |
| [short-term triple therapy with pantoprazole, clarithromycin and metronidazole for the healing of helicobacter pylori infection]. | in a prospective study 27 patients (13 women, 14 men; mean age 62 [45-83] years) with helicobacter (h.) pylori associated disease received over 7 days pantoprazole (40 mg twice daily), clarithromycin (500 mg twice daily) and metronidazole (500 mg twice daily). six patients had gastric ulcer, 4 duodenal ulcer, 4 erosive gastritis, 6 erosive duodenitis and 7 had h. pylori-positive functional dyspepsia. pre-treatment oesophago-gastro-duodenoscopy was combined in 4 patients with antral and in 4 othe ... | 1995 | 7889816 |
| use of a receiver operating characteristic in the evaluation of two commercial enzyme immunoassays for detection of helicobacter pylori infection. | two novel commercial igg enzyme immunoassay (eia) systems based on acid-glycine-extracted (pyloriset igg eia, orion diagnostica) or fast protein liquid chromatography-purified (cobas core anti-h. pylori eia, roche diagnostic systems) helicobacter antigens were evaluated in a prospective study involving 127 patients. all patients underwent upper endoscopy with biopsy, and biopsies were examined for the presence of helicobacter pylori by a rapid urease test, microscopy and culture. of the 71 patie ... | 1994 | 7889950 |
| luxuriant growth of helicobacter pylori and campylobacter species in candle jars after primary isolation. | 1994 | 7889954 | |
| changes in the intragastric distribution of helicobacter pylori during treatment with omeprazole. | omeprazole is a powerful inhibitor of gastric acid and may suppress helicobacter pylori by effecting the pka of h pylori urease, by altering the pattern of infection, or by promoting overgrowth of other bacteria. at routine endoscopy h pylori was detected by histology and culture before and after four weeks' treatment with omeprazole, 40 mg each morning. a 13c-urea breath test was also done at t = 0, 2, 4, and 6 weeks. thirty nine patients with duodenal ulcer (n = 25) or reflux oesophagitis (n = ... | 1995 | 7890214 |
| duodenal ulcer, gastric acid, and helicobacter pylori. | 1995 | 7890223 | |
| unethical research relating to helicobacter pylori? | 1995 | 7890229 | |
| activation of human thp-1 cells and rat bone marrow-derived macrophages by helicobacter pylori lipopolysaccharide. | the mechanism by which helicobacter pylori, which has little or no invasive activity, induces gastric-tissue inflammation and injury has not been well characterized. we have previously demonstrated that water-extracted proteins of h. pylori are capable of activating human monocytes by a lipopolysaccharide (lps)-independent mechanism. we have now compared activation of macrophages by purified lps from h. pylori and from escherichia coli. lps was prepared by phenol-water extraction from h. pylori ... | 1995 | 7890370 |
| effect of oral immunization with recombinant urease on murine helicobacter felis gastritis. | the ability of oral immunization to interfere with the establishment of infection with helicobacter felis was examined. groups of swiss webster mice were immunized orally with 250 micrograms of helicobacter pylori recombinant urease (rurease) and 10 micrograms of cholera toxin (ct) adjuvant, 1 mg of h. felis sonicate antigens and ct, or phosphate-buffered saline (pbs) and ct. oral immunization with rurease resulted in markedly elevated serum immunoglobulin g (igg), serum iga, and intestinal iga ... | 1995 | 7890380 |
| helicobacter pylori infection increases following cholecystectomy. | cholecystectomy is frequently linked with duodenogastric reflux and gastritis but its effect on helicobacter pylori (h pylori) infection has not been examined. in a prospective study, twenty two patients with documented cholelithiasis underwent upper gastrointestinal endoscopy and biopsy and 24hr dual channel ph monitoring prior to cholecystectomy and again at 3-6 months post-operatively. the antral biopsies were histologically assessed for h pylori and gastritis and awarded an alkaline reflux s ... | 1995 | 7890538 |
| treatment of low-grade gastric malt lymphoma with helicobacter pylori eradication. | 1995 | 7891510 | |
| non-motile mutants of helicobacter pylori and helicobacter mustelae defective in flagellar hook production. | flagellar hooks were purified from helicobacter pylori and helicobacter mustelae. the 70 x 16 nm h. pylori hook was composed of flge subunits of 78kda, while the 72 x 16 nm h. mustelae hook was composed of 87 kda subunits. n-terminal sequence was obtained for the flge proteins of both species, and for an internal h. mustelae flge peptide. degenerate oligonucleotide primers allowed amplification of a 1.2 kb fragment from the h. mustelae chromosome, which carried part of the flge gene. the corresp ... | 1994 | 7891557 |
| helicobacter pylori infection and gastric juice vitamin c levels. impact of eradication. | h. pylori has recently been recognized as a novel risk factor of gastric cancer, but its precise role in gastric carcinogenesis is as yet unknown. the aim of the present study was to assess the relationship between h. pylori infection and vitamin c levels in gastric juice and also to examine whether eradication of h. pylori could have any impact on these levels. gastric juice and plasma vitamin c levels were measured in 88 dyspeptic patients who had an upper gastrointestinal endoscopy. in the su ... | 1995 | 7895555 |
| high-dose omeprazole plus amoxicillin or clarithromycin cures helicobacter pylori infection in duodenal ulcer disease. | treatment with omeprazole plus amoxicillin or clarithromycin resulted in encouraging helicobacter pylori cure rates in pilot and controlled studies. the present prospective, randomized study was designed to compared the efficacy and safety of amoxicillin and clarithromycin as constituents of omeprazole-enhanced antibiotic therapy of h. pylori infection. fifty patients with active duodenal ulcer disease and histologically and/or culturally confirmed h. pylori colonization of the gastric mucosa we ... | 1995 | 7895926 |
| [prognostic significance of helicobacter pylori isolation in patients with peptic ulcer]. | the author shows that persistent contamination of the mucosa in ulcer patients noticeable even after ulcer healing with helicobacter pylori leads to disordered coordination of energetic processes in immunocompetent cells. the reserve pathway becomes more active than basic pathway of oxidation, this combining with lymphocyte sensitization to the mucosal tissue. an unfavourable prognostic implication is given to a 1.5-fold inhibition of lymphocyte succinate dehydrogenase activity. if alpha-glycero ... | 1994 | 7898008 |
| non-endoscopic method to obtain helicobacter pylori for culture. | a sampling method to collect samples for helicobacter pylori culture that is easier than endoscopy would be useful. we used a capsule attached to a highly absorbent nylon string, which is swallowed to obtain gastric secretions. antral biopsy and string specimens, sequentially obtained from 36 adults with clinically suspected ulcer or gastric disease were cultured. 9 (25%) patients were negative in both tests; 18 (50%) were positive by both methods; 6 (17%) were biopsy positive and string-test ne ... | 1995 | 7898181 |
| effect of acid suppression on efficacy of treatment for helicobacter pylori infection. | eradication of helicobacter pylori from the stomach by triple therapy with bismuth, tetracycline, and metronidazole cures peptic ulcer disease. we investigated whether concomitant acid inhibition with omeprazole would improve the results of triple therapy. 108 consecutive patients with peptic-ulcer disease and biopsy-proven h pylori infection were randomised to 7 days of triple therapy with or without omeprazole 20 mg twice daily. patients in the omeprazole-treated group were pretreated with 3 d ... | 1995 | 7898228 |
| coccoid helicobacter pylori not culturable in vitro reverts in mice. | an experimental rodent model was used to demonstrate the viability of the coccoid form of helicobacter pylori. concentrated suspensions were prepared for the two different morphologies: at 2 days incubation for the bacillary forms and at 20 days incubation for the "dormant" forms. the strains used for incubation were two fresh isolates from humans with duodenal ulceration, and two collection strains. five hundred microliters of culture (od550 = 5 mc farland) of helicobacter pylori with bacillary ... | 1994 | 7898382 |
| growth medium containing cyclodextrin and low concentration of horse serum for cultivation of helicobacter pylori. | the growth of helicobacter pylori, a gram-negative microaerophilic bacterium, is often difficult and requires complex media with the supplementation of 5% to 10% blood or blood derivatives. we have found that brucella broth supplemented with 1% heated horse serum and 0.1% beta-cyclodextrin supports the good growth of h. pylori. the degree of growth and production of urease and vacuolating cytotoxin in this medium were equal to those in the medium supplemented with 5% horse serum. this medium was ... | 1994 | 7898389 |
| [helicobacter pylori, a rediscovered bacterium. implication in gastroduodenal diseases]. | helicobacter pylori is a microaerophilic bacterium initially found in the gastric antrum of patients with peptic ulcer disease. as a result, h. pylori is now believed to have a pathophysiologic role in gastritis as well as in peptic ulcer disease. several recent studies showed that it may be associated with duodenal ulcer relapse and that eradication therapy using antibiotics may significantly decrease the ulcer recurrence rate in duodenal ulcer patients. moreover, epidemiological studies sugges ... | 1995 | 7899350 |
| [the omeprazole treatment of patients with diseases of the upper digestive tract]. | effectiveness of the use of omeprazolum (oside) was studied in 24 patients with ulcer disease, 16 patients with chronic primary gastroduodenitis and 18 patients with acid reflux-esophagitis. the preparation oside is a highly effective agent for the treatment of the aforementioned conditions and possesses a powerful antisecretory and antioxidant activity. against the background of the use of the preparation the count of helicobacter pylori gets decreased in the antral part of the stomach. the use ... | 1994 | 7900331 |
| mechanisms involved in helicobacter pylori-induced inflammation. | helicobacter pylori infection is associated with mucosal inflammation. the aims of the present study were to assess whether a water extract of h. pylori promotes neutrophil (polymorphonuclear leukocyte [pmn]) adherence to endothelial cells and define the molecular basis of this adhesive interaction. | 1993 | 7901109 |
| transmission of helicobacter pylori via faeces. | 1993 | 7901696 | |
| helicobacter pylori causes hyperproliferation of the gastric epithelium: pre- and post-eradication indices of proliferating cell nuclear antigen. | to assess the effect of helicobacter pylori (hp) eradication on the proliferation of the gastric epithelium by the expression of the proliferating cell nuclear antigen (pcna). | 1993 | 7901989 |
| effect of helicobacter pylori eradication on antral gastrin- and somatostatin-immunoreactive cell density and gastrin and somatostatin concentrations. | the density of antral gastrin (g)- and somatostatin (d)-immunoreactive cells and the contents of antral gastrin and somatostatin were investigated in endoscopic antral biopsy specimens from patients with duodenal ulcer before and after eradication of helicobacter pylori. after h. pylori eradication both antral somatostatin concentration (p = 0.0002) and antral d-cell density (p = 0.01) increased significantly. conversely, although the number of g-cells was unchanged, antral (p = 0.0002) and seru ... | 1993 | 7903471 |
| [restriction endonuclease (noti) analysis of chromosomal dna of helicobacter pylori by pfge]. | with the goal of differentiating h. pylori in order to clarify its pathogenicity, we have conducted a restriction endonuclease of the chromosomal dna of 24 strains of h. pylori employing the restriction endonucleases, noti, cpoi, kpni, and smai using pulsed-field gel electrophoresis (pfge). with noti, these 16 strains out of 24 strains were completely digested, and 16 clearly different electrophoretic patterns of noti digested chromosomal dna fragments were seen, permitting us to successfully di ... | 1993 | 7904319 |
| [polymorphism of helicobacter pylori urease genes and gastric diseases]. | helicobacter pylori (hp) is now recognized as a major etiologic agent of chronic gastritis and peptic ulcer and is recently presumed to be a cofactor in the occurrence of gastric cancer. hp has a high urease activity, which possibly plays a role in the pathogenesis of gastroduodenal diseases. in this paper, the function and the genetic structure of hp urease gene and the restriction fragment length polymorphism (rflp) among hp strains using a probe of hp urease alpha subunit gene were described. ... | 1993 | 7904320 |
| [the role of eradication of helicobacter pylori in healing and recurrence of gastric ulcer]. | it is now generally accepted that infection with helicobacter pylori is the most common cause of active chronic gastritis and duodenal ulceration. although h. pylori is detected in the majority of patients with gastric ulcer, its pathogenicity and role in gastric ulceration remains unclear. one method to study this relationship is to eradicate h. pylori and observe the recurrence of gastric ulcer. in the present paper we examined the consequence of h. pylori eradication by antibiotics mono thera ... | 1993 | 7904321 |
| serum levels of pepsinogen i in healthy volunteers and patients with gastric ulcers and gastric carcinoma in taiwan. | in order to investigate the clinical usefulness of human pepsinogen i (pgi) as a noninvasive diagnostic tool for gastric lesions, 92 healthy volunteers, 87 patients with a gastric ulcer and 94 patients with gastric carcinoma, verified by histologic examinations, were enrolled. the serum level of pgi in each patient was measured by radioimmunoassay. mean serum pgi levels were 95.4 +/- 39.4 ng/ml in patients with gastric ulcers, 77.6 +/- 29.3 ng/ml in healthy volunteers, and 52.1 +/- 26.5 ng/ml in ... | 1993 | 7904845 |
| eradication of helicobacter pylori infection and the recurrence of duodenal ulcers. | the purpose of this study was to compare the performance of different regimens on helicobacter pylori (h. pylori) eradication and duodenal ulcer recurrence. during a four-week period, 59 patients with duodenal ulcers who were positive for h. pylori infection were randomly treated with one of three regimens. seventeen patients were treated with ranitidine, 19 with colloidal bismuth subcitrate (cbs), and 23 with triple therapy (cbs, tetracycline and metronidazole). forty-six patients with healed u ... | 1993 | 7904847 |
| duodenal ulcer treated with helicobacter pylori eradication: seven-year follow-up. | the long-term benefits of helicobacter pylori-eradication treatment (het) in h pylori-associated duodenal ulcer are unclear. we followed up patients with duodenal ulcers from a trial of h pylori eradication in 1985-86. 63 of 78 patients (81%) were reviewed clinically and had upper gastrointestinal endoscopy with gastric antral biopsy. of 35 patients previously rendered h pylori negative, 32 (92%) remained h pylori negative after 7.1 years (mean). all patients initially h pylori positive remained ... | 1994 | 7905095 |
| local and systemic immune response in helicobacter pylori-associated chronic gastritis before and after treatment. | ten patients with helicobacter pylori-associated chronic gastritis were given combination therapy for 6 weeks with a bismuth subnitrate-containing compound and bacampicillin. the eradication rate was 40% 6 weeks after the end of treatment. two patients remained h. pylori-negative at long-term follow-up after 6 and 17 months; that is, h. pylori was only eradicated in 20% of the patients after long-term observation. by dot blot and immunoblotting both urease and an urease-associated heat shock pro ... | 1993 | 7905661 |
| low dose, short duration therapy for the eradication of helicobacter pylori in patients with duodenal ulcer. | to study the efficacy and acceptability of low dose, short duration triple therapy in eradicating helicobacter pylori from patients with duodenal ulcer. | 1994 | 7906009 |
| duodenal ulcer healing by eradication of helicobacter pylori without anti-acid treatment: randomised controlled trial. | randomised trials have shown that duodenal ulcers treated by h2 blockers heal faster if helicobacter pylori is eradicated concurrently. it remains unknown whether eradication of h pylori without suppression of acid-secretion, is sufficient to allow healing. 153 patients with h pylori infection and duodenal ulcer were randomised to receive either a 1-week course of bismuth subcitrate, tetracycline, and metronidazole (76), or omeprazole for 4 weeks with the same three-drug regimen for the first we ... | 1994 | 7906759 |
| contribution of hla-dqa gene to host's response against helicobacter pylori. | 1994 | 7906783 |