Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| genotyping of acanthamoeba isolates and clinical characteristics of patients with acanthamoeba keratitis in china. | acanthamoeba keratitis (ak) is a sight-threatening corneal infection, the epidemiology of which is related to the specific genotype of acanthamoeba. in this study, the genotypes of 14 acanthamoeba isolates, each from a patient with ak, were identified according to the highly variable df3 region in the 18s rrna gene at shandong eye institute, pr china, from 2000 to 2009, and the clinical characteristics of these patients were analysed. all 14 amoebae were genotype t4, representing nine different ... | 2010 | 20056772 |
| comparison of kinematic responses of the head and spine for children and adults in low-speed frontal sled tests. | previous research has suggested that the pediatric atd spine, developed from scaling the adult atd spine, may not adequately represent a child's spine and thus may lead to important differences in the atd head trajectory relative to a human. to gain further insight into this issue, the objectives of this study were, through non-injurious frontal sled tests on human volunteers, to 1) quantify the kinematic responses of the restrained child's head and spine and 2) compare pediatric kinematic respo ... | 2009 | 20058560 |
| [changes in the thyroid activity and influence of dehydroepiandrosterone-sulfate under the cold and not cold influence]. | the dehydroepiandrosterone-sulfate (dheas) effect on thyroxine (t4) and triiodothyronine (t3) levels, after the multiple (for 19 days, 1 hr a day) cold (+4 degrees) or stress without cold factor (agitation of rats on the laboratory scrambler) and the possible participation of mu-opioid receptors in this dheas effect in male rats. it is shown that dheas (30 mg/kg) caused the additional increased t4 and t3 levels indicated the activation of thyroid system. under multiple stress-factor, the express ... | 2009 | 20058821 |
| the star chart to ta bladder cancer: an unsophisticated analysis of two-dimensional gel electrophoresis proteome maps. | to explore the use of two-dimensional gel electrophoresis (2de) for analysing the proteome of clinically relevant tissue samples such as biopsies from transurethral resections of the bladder (turb), by generating a ta proteome map, possibly identifying technical or biological artefacts, and searching for biological subgroups associated with clinical data. | 2010 | 20059407 |
| influence of class m1 glutathione s-transferase (gst mu) polymorphism on gst m1 gene expression level and tumor size in oral squamous cell carcinoma. | glutathione s-transferases (gst) are antioxidant enzymes and oxidative stress markers in oral carcinogenesis. they present a system of polymorphic proteins. some variants are associated with increased sensitivity to toxic compounds, as it is known for the gstm1-null variant allele. however, the influence of the gstm1 allele variant genotype on gstm1-mrna quantity in oral squamous cell carcinoma (oscc) and normal mucosa as well as the impact on prognosis remains unclear. the genotype for gstm1 (m ... | 2010 | 20060357 |
| novel multifunctional pharmaceutical excipients derived from microcrystalline cellulose-starch microparticulate composites prepared by compatibilized reactive polymer blending. | the choice of excipients remains a critical factor in pharmaceutical formulations. microcrystalline cellulose-maize starch composites (mcc-mst) have been prepared by mixing colloidal dispersions of microcrystalline cellulose (mcc) with 10% (w/w) of chemically gelatinized maize starch (mst) at controlled temperature conditions for use as multifunctional excipients with direct compression and enhanced disintegration abilities. the novel excipient was evaluated for its direct compression and enhanc ... | 2010 | 20060448 |
| dna crunching by a viral packaging motor: compression of a procapsid-portal stalled y-dna substrate. | many large double-stranded dna viruses employ high force-generating atp-driven molecular motors to package to high density their genomes into empty procapsids. bacteriophage t4 dna translocation is driven by a two-component motor consisting of the procapsid portal docked with a packaging terminase-atpase. fluorescence resonance energy transfer and fluorescence correlation spectroscopic (fret-fcs) studies of a branched (y-junction) dna substrate with a procapsid-anchoring leader segment and a sin ... | 2010 | 20060554 |
| parental bonding and self-esteem as predictors of severe depressive symptoms: a 10-year follow-up study of norwegian physicians. | elevated rates of suicide and depression among physicians have been reported. the associations between perceived parental bonding and depressive symptoms have yet to be studied longitudinally in this occupational group. in a nationwide cohort, we sought to study parental bonding as a predictor for severe depressive symptoms and to determine whether self-esteem mediates this relationship. after graduation (t1), medical students (n = 631) were followed-up after 1 (t2), 4 (t3), and 10 (t4) years. t ... | 2010 | 20061865 |
| outcomes after stereotactic lung radiotherapy or wedge resection for stage i non-small-cell lung cancer. | purpose to compare outcomes between lung stereotactic radiotherapy (sbrt) and wedge resection for stage i non-small-cell lung cancer (nsclc). patients and methods one hundred twenty-four patients with t1-2n0 nsclc underwent wedge resection (n = 69) or image-guided lung sbrt (n = 58) from february 2003 through august 2008. all were ineligible for anatomic lobectomy; of those receiving sbrt, 95% were medically inoperable, with 5% refusing surgery. mean forced expiratory volume in 1 second and diff ... | 2010 | 20065181 |
| [measurement of thyroid autoantibodies in graves' disease.] | it is thought that dietary iodine may play a role in thyroid autoimmune reactivity. iceland is an iodine rich area and therefore it seemed interesting to measure autoantibodies against tsh receptor (trab), thyroid peroxidase (tpo) and thyroglobulin (tg) in icelandic patients with graves' disease. serum samples were collected from 47 patients with untreated graves' disease, 73 patients with graves' disease that had been treated with radioiodine (u1i), most of them (56) hypothyroid following the t ... | 1996 | 20065407 |
| [results of cultures and serotyping of s. pyogenes 1986-1993.] | streptococcus pyogenes is a major human pathogen. it is a common cause of pharyngitis, cellulitis and wound infections. late complications like rheumatoid arthritis and glomerulonephritis are associated with certain m proteins on the surface of the bacteria. in 1987 an increase was noted in the incidence of serious infections caused by this bacterium. the increase has been associated with protein type m 1. typing with antibodies against t proteins is simpler to perform than m typing and can give ... | 1995 | 20065464 |
| [results of individually adjusted radioiodine treatment of hyperthyroidism.] | radioiodine (131i) treatment was started in iceland in 1960 and the same formula has been used from the beginning to calculate the doses of radioactivity aiming for 70 gy irradiation of the gland. in the present investigation we studied 468 patients who were treated over a period of 19 years (1973-1991). about 90% of the patients had graves' disease (gd), 9% toxic adenoma but less than 1% toxic multinodular goiter. approximately 70% of the gd patients became hypothyroid (subclinical hypothyroidi ... | 1995 | 20065472 |
| bacteriophage adsorption efficiency and its effect on amplification. | existing models for bacteriophage adsorption are modified with the addition of a new term, adsorption efficiency, and applied to a t4-escherichia coli system. the adsorption efficiency is the fraction of phage that adsorbs irreversibly to the host. adsorption kinetics were modeled using the adsorption rate constant(k) and the adsorption efficiency(epsilon). experimental data demonstrated that the adsorption rate constant depends strongly on the condition of the host while the adsorption efficien ... | 2010 | 20066440 |
| [clinical application of mutidetector computer tomography in diagnosing t staging of gastric carcinoma]. | to evaluate the significance of plain and dual-phasic enhanced mdct in the diagnosis of preoperative t staging of gastric carcinoma. | 2009 | 20067130 |
| apical node metastasis independently predicts poor survival in dukes c colorectal cancer. | the prognostic significance of apical node metastasis in node-positive colorectal cancer (crc) is disregarded by the fourth american joint committee on cancer and the international union against cancer (ajcc/uicc) tnm classification system. the influence of apical node metastases on overall 5-year survival among patients with dukes stage c crc was examined. | 2011 | 20070342 |
| base of skull recurrences after treatment of salivary gland cancer with perineural invasion reduced by postoperative radiotherapy. | to determine the effect of postoperative radiation therapy for salivary gland carcinomas in the presence of microscopic perineural invasion. | 2009 | 20070763 |
| [the diagnostic value of microsatellite loh analysis and the prognostic relevance of angiogenic gene expression in urinary bladder cancer]. | bladder cancer is the second most common malignancy affecting the urinary system. currently, histology is the only tool that determines therapy and patients' prognosis. as the treatment of non-invasive (ta/t1) and muscle invasive (t2-t4) bladder tumors are completely different, correct staging is important, although it is often hampered by disturbing factors. molecular methods offer new prospects for early disease detection, confirmation of unclear histological findings and prognostication. appl ... | 2009 | 20071311 |
| the effect of alcohol consumption on later obesity in early adulthood--a population-based longitudinal study. | the study aimed to determine whether alcohol use during late adolescence contributes to the weight gain from adolescence to young adulthood or risk of obesity or waist circumference at young adulthood. | 2010 | 20071348 |
| potential for medical error: incorrectly completed request forms for thyroid function tests limit pathologists' advice to clinicians. | various publications have highlighted the significance of laboratory errors in the pre- and post-analytical phases and their impact on results. thyroid-stimulating hormone (tsh) is a first-line thyroid function test and, if abnormal, reflex thyroxine (t4) or tri-iodothyronine (t3) testing is requested, depending on clinical and medication data provided. interpretative comments are added to all tft results. | 2009 | 20073294 |
| painless thyroiditis complicated by acromegaly. | the serum thyroid stimulating hormone (tsh) level is decreased in acromegalic patients. although this phenomenon is thought to be caused by the enhanced secretion of somatostatin which suppresses tsh production, it has not yet been proven. we describe a 60-year-old woman with acromegaly who showed a low concentration of tsh. we diagnosed her as painless thyroiditis based on an increased level of thyroglobulin, depressed radioactive iodine uptake (raiu), normal vascularity and mild swelling of th ... | 2010 | 20075583 |
| loss of udp-galnac:polypeptide n-acetylgalactosaminyltransferase 3 and reduced o-glycosylation in colon carcinoma cells selected for hepatic metastasis. | o-glycosylation of mucin is initiated by the attachment of n-acetyl-d-galactosamine (galnac) to serine or threonine residues in mucin core polypeptides by udpgalnac:polypeptide n-acetylgalactosaminyltransferases (ppgalnac-ts). it is not well understood how galnac attachment is regulated by multiple ppgalnac-ts in each cell. in the present study, the expression levels of murine ppgalnac-ts (mgalnac-ts), t1, t2, t3, t4, t6, and t7 were compared between mouse colon carcinoma colon 38 cells and vari ... | 2010 | 20077002 |
| effects of gestational exposure to decabromodiphenyl ether on reproductive parameters, thyroid hormone levels, and neuronal development in sprague-dawley rats offspring. | polybrominated diphenyl ethers (pbde) are a class of brominated flame retardants that are recognized as global environmental contaminants with potential adverse effects on human health. this study examined the effects of prenatal exposure to pbde on reproductive organs, neuronal development, and levels of thyroid hormones. pregnant rats were exposed to the vehicle or deca-bromodiphenyl ether (bde) (bde-209; 5, 40, or 320 mg/kg body weight/d) during gestation days (gd) 6-18. there was a significa ... | 2009 | 20077200 |
| exposure assessment of polybrominated diphenyl ethers (pbde) in umbilical cord blood of korean infants. | this study examined the levels of polybrominated diphenyl ethers (pbde) in the umbilical cord blood of infants, and investigated the relationship between pbde concentration and thyroid hormone levels. the concentration of pbde were measured in the cord blood samples of 108 infants collected in cheil woman's hospital, seoul, korea, in 2007. of 108 pregnant woman reported, the average age was 31.9 +/- 3.54 yr (range 20-42 yr). the mean body weight of the infants was 3.15 +/- 0.57 kg (1.89-4.43 kg) ... | 2009 | 20077203 |
| [care continuity for patients with congenital hypothyroidism during transition from childhood to adulthood]. | since the nation-wide neonatal screening programs for congenital hypothyroidism(ch) had been implemented in 1979, the diagnosis and treatment of ch are now provided in the first 2-3 weeks of birth in japan. the goals of treatment are to raise the serum t4 as rapidly as possible into the normal range, and maintain normal growth and development while avoiding overtreatment. because transient hypothyroidism may occur frequently, a reevaluation after 3 years is needed in such patients. patients with ... | 2010 | 20077804 |
| [tonsillar carcinoma: analyses of the therapy and prognostic factors]. | to retrospectively analyze the therapeutic effect on patients with tonsillar carcinoma and factors affecting their prognosis. | 2009 | 20079056 |
| effect of melatonin supplementation on plasma vasopressin response to different conditions in rats with hyperthyroidism induced by l-thyroxine. | the present study was performed to determine how basal, isotonic, hypertonic and hypovolemic conditions affect fluid-electrolyte balance and plasma arginine vasopressin (avp) levels in rats with experimental hyperthyroidism supplemented with melatonin. the rats were divided into four groups of twenty-four subjects each kept under the following treatments during one month: (1) controls; (2) treated with l-thyroxine; (3) treated with l-thyroxine and sham melatonin and (4) treated with l-thyroxine ... | 2010 | 20079381 |
| characterizing the in vitro hepatic biotransformation of the flame retardant bde 99 by common carp. | polybrominated diphenyl ethers (pbdes) are a class of flame retardant chemicals known to biomagnify in aquatic foodwebs. however, significant biotransformation of some congeners via reductive dehalogenation has been observed during in vivo and in vitro laboratory exposures, particularly in fish models. little information is available on the enzyme systems responsible for catalyzing this metabolic pathway in fish. this study was undertaken to characterize the biotransformation of one primary bde ... | 2010 | 20080306 |
| micron-scale holes terminate the phage infection cycle. | holins are small phage-encoded proteins that accumulate harmlessly in the cytoplasmic membrane during the infection cycle until suddenly, at an allele-specific time, triggering to form lethal lesions, or "holes." in the phages lambda and t4, the holes have been shown to be large enough to allow release of prefolded active endolysin from the cytoplasm, which results in destruction of the cell wall, followed by lysis within seconds. here, the holes caused by s105, the lambda-holin, have been captu ... | 2010 | 20080651 |
| should direct mesocolon invasion be included in t4 for the staging of gastric cancer? | one of the sites most frequently invaded by gastric cancer is the mesocolon; however, the uicc does not mention this anatomical site as an adjacent structure involved in gastric cancer. the purpose of this study was to characterize and classify mesocolon invasion from gastric cancer. | 2010 | 20082356 |
| evaluation of isotope-coded protein labeling (icpl) in the quantitative analysis of complex proteomes. | an evaluation of the icpl (isotope-coded protein labeling) non-isobaric labeling technique was performed using two different biological models. two samples containing phage t4 capsids were mixed in a 1:1 ratio after being labeled with the light or heavy versions of the icpl reagent. the analysis of this proteome demonstrated the feasibility of this approach for differential quantitative proteomics and was employed to optimize the experimental parameters of the icpl workflow. icpl-mediated analys ... | 2010 | 20082807 |
| genetics and phenomics of selenoenzymes--how to identify an impaired biosynthesis? | expression of selenoenzymes relies on the se supply and specific cis- and trans-acting factors. two inherited defects are caused by dysfunctional selenoproteins or insufficient biosynthesis, i.e., selenoprotein n-related myopathy and impaired selenoprotein translation secondary to hypomorphic mutations in sbp2. the latter affects biosynthesis of many selenoenzymes including the deiodinase activities. a strategy to identify individuals carrying a mutation in a specific selenoprotein gene can be b ... | 2010 | 20083162 |
| association between a high number of isolated lymph nodes in t1 to t4 n0m0 colorectal cancer and the microsatellite instability phenotype. | stage i or ii colorectal carcinomas with microsatellite instability (msi) are characterized by more isolated lymph nodes in the resected specimen than their counterparts with microsatellite stability (mss). | 2010 | 20083749 |
| thyroid profile of term appropriate for gestational age neonates in nigeria: a forerunner to screening for congenital hypothyroidism. | thyroid hormones in normal quantity are vital for physical growth and mental development during fetal and postnatal life. the available publications in sub-saharan africa on the thyroid function of newborn infants was reported in babies delivered in moderate to severe goitre zones; utilizing the hormone levels from these studies may have a measure of bias. newborn screening for congenital hypothyroidism (ch) in sub-saharan africa is still a mirage, the technicality of the best timing for collect ... | 2010 | 20085966 |
| systemic thyroid hormone is necessary and sufficient to induce ultraviolet-sensitive cone loss in the juvenile rainbow trout retina. | rainbow trout possess ultraviolet-sensitive (uvs) cones in their retina that degenerate naturally during development. this phenomenon can be induced with exogenous thyroxine [t4, a thyroid hormone (th)] treatment. however, the previous t4 exposure experiments employed static water immersion; a method that could introduce confounding stress effects on the fish. because of this, it was uncertain if t4 alone was sufficient to induce retinal changes or if stress-related hormones were also necessary ... | 2010 | 20086135 |
| advances in the relationship between lymph node status and prognosis: comment on "association between a high number of isolated lymph nodes in t1 to t4 n0m0 colorectal cancer and the microsatellite instability". | 2010 | 20088097 | |
| reaction mechanisms of the multicopper oxidase cueo from escherichia coli support its functional role as a cuprous oxidase. | cueo from escherichia coli is a multicopper oxidase (mco) involved in copper tolerance under aerobic conditions. it features four copper atoms that act as electron transfer (t1) and dioxygen reduction (t2, t3; trinuclear) sites. in addition, it displays a methionine-rich insert which includes a helix that blocks physical access to the t1 site and which provides an extra labile site t4 adjacent to the t1 center. this t4 site is required for cueo function. like many mcos, cueo exhibits phenol oxid ... | 2010 | 20088522 |
| thyroid autoimmunity and treatment response to escitalopram in major depression. | there is evidence that immune alterations play an important part in the pathogenesis of major depression. thyroid autoimmunity has been found in association with major depression in several studies. | 2010 | 20088751 |
| analytic review: thyrotoxic periodic paralysis: a review. | thyrotoxic periodic paralysis (tpp) is an unusual complication of hyperthyroidism that frequently presents in a dramatic fashion, necessitating treatment in an emergency department or admission to an intensive care unit. thyrotoxic periodic paralysis is characterized by transient, recurrent episodes of flaccid muscle paralysis affecting proximal more severely than distal muscles. thyrotoxic periodic paralysis is most commonly a complication of graves' disease in asian males, although in recent d ... | 2010 | 20089526 |
| high-frequency phage-mediated gene transfer in freshwater environments determined at single-cell level. | lateral gene transfer by phages has contributed significantly to the genetic diversity of bacteria. to accurately determine the frequency and range of phage-mediated gene transfer, it is important to understand the movement of dna among microbes. using an in situ dna amplification technique (cycling primed in situ amplification-fluorescent in situ hybridization; cprins-fish), we examined the propensity for phage-mediated gene transfer in freshwater environments at the single-cell level. phage p1 ... | 2010 | 20090786 |
| [exploration on neoadjuvant chemoradiation in the treatment for locally advanced low rectal cancer]. | to explore the possibility of further improvement of the efficacy of neoadjuvant chemoradiotherapy in locally advanced lower rectal cancer and the management of patients with clinical complete regression. | 2009 | 20092741 |
| sympathetic nervous system effects in the hands following a grade iii postero-anterior rotatory mobilisation technique applied to t4: a randomised, placebo-controlled trial. | joint mobilisation to the t4 vertebra has been advocated as a treatment for t4 syndrome. to date no controlled studies have investigated the effects of thoracic spinal manual therapy (smt) applied to t4 on sympathetic activity in the hands. this study investigated whether a grade iii postero-anterior rotatory joint mobilisation technique applied to the t4 vertebra at a frequency of 0.5 hz had demonstrably greater effects than a validated placebo intervention on skin conductance (sc) in the hands ... | 2010 | 20093065 |
| oxidative stress: a required condition for thyroid cell proliferation. | goiter is associated with increased oxidative stress (os). we studied the effects of an anti-inflammatory agent, 15 deoxy-delta12,14-prostaglandin j2 (15dpgj2) and an antioxidant, n-acetylcysteine (nac), on os, thyroid function, and goiter expansion in a model of goiter induced by propylthiouracil (ptu) or perchlorate. os was assessed by the immunodetection of 4-hydroxynonenal, thyroid function by measuring thyroxin (t4) and thyrotropin (tsh) plasma levels and detecting t4-rich thyroglobulin (tg ... | 2010 | 20093493 |
| lessons from the lysozyme of phage t4. | an overview is presented of some of the major insights that have come from studies of the structure, stability, and folding of t4 phage lysozyme. a major purpose of this review is to provide the reader with a complete tabulation of all of the variants that have been characterized, including melting temperatures, crystallographic data, protein data bank access codes, and references to the original literature. the greatest increase in melting temperature (t(m)) for any point mutant is 5.1 degrees ... | 2010 | 20095051 |
| compensatory mechanisms to maintain blood pressure in paraplegic rats: implication of central tachykinin nk-1 and nk-3 receptors? | people with high level spinal cord injury (sci) suffer from both hypotension and spontaneous hypertension due to loss of supraspinal control of spinal sympathetic outflow. few reports have addressed whether any changes occur in central regulation of blood pressure (bp) and heart rat (hr) at the supraspinal level. central tachykinin nk-1 and nk-3 receptors are located in many cardiovascular areas in the brain and are known to modulate bp and hr. this study examined the intracerebroventricular (i. ... | 2010 | 20096457 |
| metabolic effects of 20-oh-ecdysone in ovariectomized rats. | postmenopausal women develop often obesity which may be prevented by 20-oh-ecdysone (ecd). this was investigated in ovariectomized (ovx) rats. they were orally treated with 3 doses of ecd (18, 56 or 116 mg/day/animal). positive controls received 159 microg estradiol (e2). quantitative computer tomography at the level of the abdomen and the metaphysis of the tibia allowed estimation of surface, fat depots and muscles. the highest dose of ecd resulted in serum concentrations of 0.4 x 10(-6)m. seru ... | 2010 | 20097286 |
| comparison of the molecular influences of no-induced lesions in dna strands on the reactivity of polynucleotide kinases, dna ligases and dna polymerases. | nitric oxide (no) causes dna damage, generating xanthine (xan, x) and oxanine (oxa, o) from guanine (gua, g) and hypoxanthine (hyp, h) from adenine (ade, a) by nitrosative oxidation. although these no-induced lesions have been thought to cause mutagenic problems in cellular systems, the influence of these lesions on enzymatic functions has not yet been compared systematically. in this study, we investigated the effect of no-induced lesions on the activities of dna-binding/recognizing enzymes suc ... | 2010 | 20097903 |
| 3-o-methylfunicone, a selective inhibitor of mammalian y-family dna polymerases from an australian sea salt fungal strain. | we isolated a pol inhibitor from the cultured mycelia extract of a fungal strain isolated from natural salt from a sea salt pan in australia, which was identified as 3-o-methylfunicone by spectroscopic analyses. this compound selectively inhibited the activities of mammalian y-family dna polymerases (pols) (i.e., pols eta, iota and kappa). among these pols, human pol kappa activity was most strongly inhibited, with an ic(50) value of 12.5 microm. on the other hand, the compound barely influenced ... | 2009 | 20098603 |
| genetic variability of vascular endothelial growth factor and prognosis of head and neck cancer in a brazilian population. | vascular endothelial growth factor (vegf) is one of the most potent endothelial cell mitogens and plays a critical role in angiogenesis. polymorphisms in this gene have been evaluated in patients with several types of cancer. the objectives of this study were to determine if there was an association of the -1154g/a polymorphism of the vegf gene with head and neck cancer and the interaction of this polymorphism with lifestyle and demographic factors. additionally, the distribution of the vegf gen ... | 2010 | 20098841 |
| phylogenetic analysis of betanodavirus isolates from australian finfish. | in australia, disease caused by betanodavirus has been reported in an increasing number of cultured finfish since the first report of mortalities in 1990. partial coat protein gene sequences from the t2 or t4 regions of 8 betanodaviruses from barramundi lates calcarifer, sleepy cod oxyeleotris lineolata, striped trumpeter latris lineata, barramundi cod cromileptes altivelis, australian bass macquaria novemaculata and gold-spotted rockcod epinephelus coioides from several australian states were d ... | 2009 | 20099409 |
| maspin and nm23-h1 expression in colorectal cancer. | the aim of the study was to analyze the expression of nm23-h1 and maspin proteins in a series of colorectal adenocarcinoma and to assess their applicability as prognostic factors in this type of cancer. 102 specimens of colorectal carcinoma were analyzed by immunohistochemistry with the use of anti-nm23-h1 and anti-maspin monoclonal antibodies. cytoplasmic expression of nm23-h1 and maspin was found in 90 of all investigated cases. in 60 cases maspin protein was found also in nucleus. medium/high ... | 2010 | 20099971 |
| heterologous expression of yeast hxt2 in arabidopsis thaliana alters sugar uptake, carbon metabolism and gene expression leading to glucose tolerance of germinating seedlings. | the hexose transporter 2 gene (hxt2) from saccharomyces cerevisiae was expressed in arabidopsis thaliana under control of the 35s promoter. several independent transgenic lines were selected after confirming single gene insertion by southern blot analysis in the t4 generation. northern blots revealed the presence of heterologous transcript. radiolabeling experiments revealed an increased rate of incorporation of the non-metabolizable analog 3-o-methyl-[u-14c]-glucose. this confirmed that the yea ... | 2010 | 20101436 |
| [case report: acanthamoeba keratitis]. | acanthamoeba keratitis (ak) is an opportunistic protozoan infection caused by the pathogenic acanthamoeba and associated with soft contact lens wear. if untreated, it can cause serious visual disability. a 23 year-old female wearing soft contact lenses applied to the department of ophthalmology of the aydin adnan menderes university school of medicine, with symptoms of redness, pain and blurred vision of both eyes. she was given a diagnosis of ak on clinical and laboratory grounds. the agent iso ... | 2009 | 20101578 |
| audit of initial management of congenital hypothyroidism in the united kingdom--comparison of uk practice with european and uk guidelines. | prompt and adequate management of newly diagnosed congenital hypothyroidism (ch) has been shown to optimise intellectual outcome. | 2009 | 20101887 |
| the use of sugammadex in a patient with myasthenia gravis. | myasthenia gravis, affecting neuromuscular transmission, leads to a large variability in sensitivity to depolarising and non-depolarising neuromuscular blocking drugs. we report the successful use of the modified mu-cyclodextrin sugammadex in a myasthenic patient to reverse a rocuronium-induced deep level of neuromuscular block. after spontaneous neuromuscular recovery of t2 (second twitch of the train-of-four series), we administered 2 mg.kg(-1) of sugammadex intravenously, reversing neuromuscu ... | 2010 | 20105151 |
| hypopituitarism is uncommon after aneurysmal subarachnoid haemorrhage. | aneurysmal subarachnoid haemorrhage (sah) has recently been reported as a common cause of chronic hypopituitarism, and introduction of routine neuroendocrine screening has been advocated. we aimed at estimating the risk of hypopituitarism after sah using strict criteria including confirmatory testing in case of suggested insufficiency. | 2010 | 20105184 |
| childhood minimally invasive follicular carcinoma: clinical features and immunohistochemistry analysis. | to report on two cases of childhood thyroid minimally invasive follicular carcinoma (mifc) to highlight the clinical features, laboratory findings and diagnosis of this rare disease. | 2010 | 20105250 |
| complications after sphincter-saving resection in rectal cancer patients according to whether chemoradiotherapy is performed before or after surgery. | the aim of the present study was to compare the influence of preoperative chemoradiotherapy (crt) with postoperative crt on the incidence and types of postoperative complications in rectal cancer patients who underwent sphincter-saving resection. | 2010 | 20106604 |
| [paraplegia after prolonged cardiac arrest and extracorporeal life support]. | paraplegia by medullar ischaemia after cardiac arrest is rarely reported, especially without an oxo-ischaemic cerebral lesions. we report the case of a 17-year-old woman who underwent a 70 minute cardiac arrest with recovery of consciousness, but a symptomatic medullar ischaemia (paraplegia under t4). | 2010 | 20106627 |
| reduced stratifin expression can serve as an independent prognostic factor for poor survival in patients with esophageal squamous cell carcinoma. | stratifin plays an important role in cancer biology by interfering with intracellular signalling pathways and cell-cycle checkpoints. decreased expression of stratifin gene has been reported to be a poor prognostic indicator in a variety of human malignant tumors. | 2010 | 20108042 |
| predictive factors of early recurrent death after a curative resection of gastric cancer. | although several prognostic factors for gastric cancer have been shown, the predictive factors of early recurrent death remain to be elucidated. this study included 402 patients who underwent a curative resection for gastric cancer. fifty-six patients died of recurrence. a multivariate analysis was performed to determine the independent factors correlated with survival time. the patients with an elevation of tumor markers, tumors in the upper one third of the stomach, deep wall invasion (t3, t4) ... | 2009 | 20108618 |
| management of sinonasal inverted papillomas and comparison of classification staging systems. | the aim of this study was to describe treatment results in patients with sinonasal inverted papilloma and to compare recent classification staging systems. | 2010 | 20109330 |
| potential to use ultraviolet-treated bacteriophages to control foodborne pathogens. | the use of replication-deficient uv-treated bacteriophages, or phages, presents an alternative to viable phages for food biocontrol applications. nontransducing uv-treated phages, if used correctly, are unlikely to produce viable progeny phages, which might otherwise mediate undesirable horizontal gene transfer events. phage t4 and escherichia coli were used as a model system to examine this possibility. uv-treated phages were able to cause a reduction in the optical density of outer membrane-fr ... | 2010 | 20113208 |
| predictors of occult nodal metastasis in colon cancer: results from a prospective multicenter trial. | the relationship between primary colon cancer and occult nodal metastases (oms) detected by cytokeratin immunohistochemistry (ck-ihc) is unknown. we sought to investigate the correlation of clinicopathologic features of colon cancer with oms and to identify predictors of om. | 2010 | 20116081 |
| preoperative therapy with trastuzumab and oral vinorelbine (+/- endocrine therapy) in patients with her2-positive breast cancer. | combined trastuzumab and intravenous vinorelbine yielded high clinical activity as preoperative treatment in patients (pts) with her 2/neu positive breast cancer. | 2010 | 20117001 |
| eeg activity during the verbal-cognitive stage of motor skill acquisition. | this study examined changes in eeg activity associated with motor performance during the verbal-cognitive stage of skill learning. participants (n=14) were required to practice a sequential finger tapping task. eeg activity was recorded both before and after short-term practice, during finger tapping and during two control conditions. eeg power (fz, cz, pz, t3, t4) and coherence (t3-fz, t4-fz, fz-cz, fz-pz) were computed for the theta (4-8 hz), slow alpha (8-10 hz), fast alpha (10-12 hz), slow b ... | 2010 | 20117168 |
| is the mechanisms of fipronil-induced thyroid disruption specific of the rat: re-evaluation of fipronil thyroid toxicity in sheep? | in rat, fipronil treatment increases the elimination of thyroid hormones (th). relevance of this mechanism for the risk of fipronil for human health is subject to controversy because of the specificities of adult rat for th plasma binding properties which often lead to the assumption that rats are more sensitive than human to thyroid disruption. this study aimed at determining if the mechanism of fipronil-induced thyroid disruption is altered in sheep a species more relevant to human from the st ... | 2010 | 20117195 |
| [changes of thyroxin and monocyte human leukocyte antigen-dr expression in senior patients with sepsis]. | o investigate the changes of thyroxin and monocyte human leukocyte antigen-dr expression in senior patients with sepsis and explore their clinical significance. | 2010 | 20118006 |
| effects of epidural fentanyl on speed and quality of block for emergency cesarean section in extending continuous epidural labor analgesia using ropivacaine and fentanyl. | we performed a prospective, randomized, and double-blind study comparing the top-up effects of 2% lidocaine/100 microg fentanyl/epinephrine (n=31) and 2% lidocaine/saline/epinephrine (n=30) when extending an epidural labor analgesia using low-dose ropivacaine and fentanyl. survival analysis for the sensory blocks to the t4 level showed no statistically significant differences in onset time to t4 between the 2 groups. onset times (min) to t4-sensory blocks for cold and pinprick were not different ... | 2010 | 20119585 |
| [evaluation of soft tissue changes after mandibular prognathism surgery]. | therapeutic goals for orthognathic surgery are not only directed towards the correction of dento-osseous deformieties but also to provide the optimal functional and esthetic effect that results in patients satisfaction. the aim of the study was to evaluate soft tissue changes following surgical treatment of patients with mandibular prognathism operated with two alternative techniques: extraoral vertical ramus osteotomy or sagittal split ramus osteotomy. | 2009 | 20120710 |
| complete frozen section margins (with measurable 1 or 5 mm thick free margin) for cancer of the tongue: part 2: clinical experience. | to obtain completely negative margins of 1 to 5 mm at the time of surgery for oral tongue squamous cell carcinoma by using a mohs-like technique. | 2010 | 20122340 |
| cardiocirculatory changes in hemorrhagic shock induced in pigs submitted to three distinct therapeutic methods. | to evaluate and compare the response of pigs submitted to hemorrhagic shock and treated using three different strategies. | 2010 | 20126901 |
| morphological, physiological and molecular biological characterisation of isolates from first cases of acanthamoeba keratitis in slovakia. | acanthamoeba keratitis (ak) is a relatively rare disease worldwide. over the past 10 years, five cases of ak were reported in slovakia. four preserved slovak strains and one strain from the czech republic isolated from corneal scrapes of patients with ak are characterised in this study. genotype identification of isolates is based on sequences of the pcr amplimer gtsa.b1 amplified from 18s ribosomal dna. a strain isolated from the first patient in 1999 was classified as a rare sequence type t15. ... | 2010 | 20127114 |
| new parameters to represent the position of the aorta relative to the spine for pedicle screw placement. | parameters of the position of the aorta in previous reports were determined for anterior surgery. this study evaluated the relative position of the aorta to the spine by new parameters, which could enhance the safety of pedicle screw placement. three parameters were defined in a new cartesian coordinate system. we selected an entry point of a left pedicle screw as the origin. the transverse plane was determined to include both the bases of the superior facet and to be parallel to the upper endpl ... | 2010 | 20127493 |
| variations in thyroidal activity during estrous cycle and natural breeding season in markhoz goat breeds. | the aim of this study was to determine the profile of changes in t3, t4 and tsh levels during breeding season and estrous cycle in markhoz (angora) goats. whereas the peaks of t3 were recorded in january, concentrations of t4 and tsh were highest in october. variations in t3 and tsh concentrations among the different months of experiments period were not significant, although t4 concentration was significantly higher during september, october and november in comparison to december and january. w ... | 2009 | 20128513 |
| comfortable lifestyle-induced imbalance of neuro-endocrine-immunity network: a possible mechanism of vascular endothelial dysfunction. | to observe the changes of vascular endothelial functions and general neuro-endocrine-immunity (nei) network under the state of qi-deficiency syndrome induced by excessive idleness and to approach their internal relevance and illuminate initially the pathophysiological mechanism of vascular lesion induced by excessive idleness. | 2010 | 20131037 |
| [free anterolateral thigh myocutaneous flap for reconstruction of soft tissue defects following en block resection of tongue cancer]. | to evaluate the results of the reconstruction of the soft tissue defects following the en block resection of tongue cancer using free anterolateral thigh myocutaneous flaps. | 2010 | 20135979 |
| [effects of water temperature and feeding on respiratory metabolism of juvenile salvelinus fontinalus]. | the oxygen consumption and ammonia excretion rates of juvenile brook trout (salvelinus fontinalus) under satiation and starvation were measured at different levels of water temperature [(5.5 +/- 0.5), (8.5 +/- 0.5), (11.5 +/- 0.5), (14.5 +/- 0.5), (17.5 +/- 0.5) degrees c], aimed to study the effects of water temperature and feeding on the respiratory metabolism of the fish. under satiation, the oxygen consumption and ammonia excretion rates of juvenile s. fontinalus at the five temperature leve ... | 2009 | 20136012 |
| [effect of neoadjuvant chemoradiotherapy on the healing of anastomosis following low anterior resection in locally advanced rectal cancer]. | to investigate the effect of the neoadjuvant chemoradiotherapy (ncr) on the healing of anastomosis following low anterior resection in patients with locally advanced rectal cancer. | 2009 | 20137397 |
| [a prognostic analysis of n0-1m0 intralobar metastatic non-small cell lung cancer]. | to assess whether it is reasonable to downgrade intralobar metastatic non-small cell lung cancer from t4 disease through a prognostic analysis of n0-1m0 disease. | 2009 | 20137436 |
| risk factors for radiation maculopathy after ophthalmic plaque radiation for choroidal melanoma. | to determine how tumor characteristics and radiation dose affect the incidence of radiation maculopathy (rm). | 2010 | 20138602 |
| potential roles for pa28beta in gastric adenocarcinoma development and diagnosis. | this study aimed to investigate the expression level of human proteasome activator pa28beta subunit (pa28beta) in gastric adenocarcinomas (ga) tissues and investigate its potential role in ga carcinogenesis. | 2010 | 20140627 |
| prevalence of undiagnosed testosterone deficiency in aging athletes: does exercise training influence the symptoms of male hypogonadism? | worldwide many aging males practice sports. a high prevalence of late-onset male hypogonadism has been observed in general population. sport-participation influences the neuroendocrine system and may decrease serum testosterone. | 2010 | 20141589 |
| volumetric analysis of thoracic and lumbar vertebral bodies. | during the last decade, vertebral augmentation techniques with cement (kyphoplasty and vertebroplasty) have revealed that 75% to 100% of individuals with osteoporotic vertebral compression fractures have good to moderate pain relief postoperatively, as well as adequate restoration of the vertebral body height. the volume of cement injected into a vertebra varied in different reports. to our knowledge, there are no studies that report on the physiological distribution of thoracic and lumbar verte ... | 2010 | 20142072 |
| histopathologic basis for the favorable survival after resection of intraductal papillary mucinous neoplasm-associated invasive adenocarcinoma of the pancreas. | to identify pathologic features that may account for the favorable survival after resection of invasive pancreatic adenocarcinoma arising in the setting of intraductal papillary mucinous neoplasm (ipmn) compared with standard pancreatic ductal adenocarcinoma (pda) in the absence of ipmn. | 2010 | 20142731 |
| long-term single-center results of management of ethmoid adenocarcinoma: 95 patients over 28 years. | to assess management options for ethmoid adenocarcinoma. | 2010 | 20146102 |
| human multidrug resistance-1 gene expression levels in graves-basedow disease. | multidrug resistance 1 gene is responsible for the resistance of a large variety of drugs in human cells. we tried to evaluate this in the present study in thyroid stimulant hormone receptor antibody positive subjects. | 2010 | 20146171 |
| an effective approach to artificial nucleases using copper(ii) complexes bearing nucleobases. | novel copper(ii) complexes bearing 2,2'-bipyridine (bpy) derivatives with adenine, thymine and uracil nucleobases [cu(l(1))cl(2)].2h(2)o (1), [cu(l(2))cl(2)] (2) and [cu(l(3))cl(2)].h(2)o (3) (l(1) = 5,5'-di[n9-adenylmethyl]-2,2'-bipyridine, l(2) = 5,5'-di[n1-thyminylmethyl]-2,2'-bipyridine and l(3) = 5,5'-di[n1-uracilmethyl]-2,2'-bipyridine) were synthesized and characterized. structure simulation was performed for these complexes. circular dichroism (cd) spectra revealed the interactions betwe ... | 2010 | 20148233 |
| thyroid dysfunction in a uk hepatitis c population treated with interferon-alpha and ribavirin combination therapy. | to assess the incidence of thyroid dysfunction (td) in a uk cohort of patients with hepatitis c virus (hcv) infection treated with interferon-alpha (ifnalpha) and ribavirin combination therapy (ifn/rbv). | 2010 | 20148905 |
| effects of certain antioxidants on lipid peroxidation process in lung homogenates of l thyroxine-receiving rats. | a possible role of antioxidants in thyreotoxicosis was investigated. we examined the parameters of lipid peroxidation (lpo): conjugated dienes (cd), malondialdehyde (mda), schiff bases (sb) in lung homogenates of male wistar rats. | 2010 | 20150865 |
| risk factors for early postoperative small bowel obstruction after colectomy for colorectal cancer. | small bowel obstruction (sbo) after colectomy leads to markedly lower patient quality of life, longer hospital stays, and increased hospitalization costs. from a systemic treatment point of view, early postoperative sbo is one of the major concerns of the surgery because it often delays chemotherapy in advanced cases. the goal of this single-center study was to evaluate the risk factors for early postoperative sbo. | 2010 | 20151126 |
| a mathematical model of hiv infection: simulating t4, t8, macrophages, antibody, and virus via specific anti-hiv response in the presence of adaptation and tropism. | a mathematical model of the host's immune response to hiv infection is proposed. the model represents the dynamics of 13 subsets of t cells (hiv-specific and nonspecific, healthy and infected, t4 and t8 cells), infected macrophages, neutralizing antibodies, and virus. the results of simulation are in agreement with published data regarding t4 cell concentration and viral load, and exhibit the typical features of hiv infection, i.e. double viral peaks in the acute stage, sero conversion, inverted ... | 2010 | 20151219 |
| benefits of thyrotropin suppression versus the risks of adverse effects in differentiated thyroid cancer. | despite clinical practice guidelines for the management of differentiated thyroid cancer (dtc), there are no recommendations on the optimal serum thyrotropin (tsh) concentration to reduce tumor recurrences and improve survival, while ensuring an optimal quality of life with minimal adverse effects. the aim of this review was to provide a risk-adapted management scheme for levothyroxine (l-t4) therapy in patients with dtc. the objective was to establish which patients require complete suppression ... | 2010 | 20151821 |
| quality of life and effectiveness comparisons of thyroxine withdrawal, triiodothyronine withdrawal, and recombinant thyroid-stimulating hormone administration for low-dose radioiodine remnant ablation of differentiated thyroid carcinoma. | few reports have examined the use of recombinant human thyroid-stimulating hormone (rhtsh) for ablation of postsurgical thyroid remnants after low-dose radioactive iodine (ri) therapy, compared with conventional thyroid hormone withdrawal. we investigated whether patient preparation using rhtsh was comparable to conventional thyroid hormone withdrawal with respect to efficacy of postsurgical remnant ablation in low-risk patients receiving a 30 mci ri. in addition, we also evaluated the impact of ... | 2010 | 20151824 |
| resistance to thyroid hormone in a patient with coexisting graves' disease. | resistance to thyroid hormone (rth) is a rare disorder in which an abnormality in the binding domain of the thyroid hormone receptor results in end-organ insensitivity to the actions of thyroid hormones. this disorder is sometimes misdiagnosed as graves' disease due to the presence of a goiter with high iodine-123 thyroid uptake and high levels of total and free thyroid hormones. additionally, some patients with rth may experience palpitations or tachycardia. there is a previous report of a pati ... | 2010 | 20151830 |
| could a wait and see policy be justified in t3/4 rectal cancers after chemo-radiotherapy? | chemoradiotherapy (crt) followed by total mesorectal excision is the standard when mri staging demonstrates threatened surgical margins in locally advanced rectal cancer (larc). interest in non-surgical management of larc as an alternative to a resection has been provoked by published excellent long-term outcomes of patients who achieve clinical complete responses (ccr) after crt. the present retrospective study aimed to determine whether similar rates of local disease control are seen in a uk c ... | 2010 | 20151936 |
| detection of t4 dna ligase using a solid-state electrochemiluminescence biosensing switch based on ferrocene-labeled molecular beacon. | a solid-state electrochemiluminescence (ecl) biosensing switch based on special ferrocene-labeled molecular beacon (fc-mb) has been successfully developed for t4 dna ligase detection. such special switch system consisted of two main parts, an ecl substrate and an ecl intensity switch. the ecl substrate was made by modifying the complex of au nanoparticle and ruthenium (ii) tris-(bipyridine) (ru(bpy)(3)(2+)-aunps) onto au electrode. a molecular beacon labeled by ferrocene as the ecl intensity swi ... | 2010 | 20152390 |
| early temporal effects of three thyroid hormone synthesis inhibitors in xenopus laevis. | thyroid axis disruption is an important consideration when evaluating risks associated with chemicals. bioassay methods that include thyroid-related endpoints have been developed in a variety of species, including amphibians, whose metamorphic development is thyroid hormone (th)-dependent. inhibition of th synthesis in these species leads to developmental delay, and assays designed to capture these effects take several weeks to complete. in an effort to develop a shorter term approach, the early ... | 2010 | 20153061 |
| solution and electron microscopy characterization of lactococcal phage baseplates expressed in escherichia coli. | we report here the characterization of several large structural protein complexes forming the baseplates (or part of them) of siphoviridae phages infecting lactococcus lactis: tp901-1, tuc2009 and p2. we revisited a "block cloning" expression strategy and extended this approach to genomic fragments encoding proteins whose interacting partners have not yet been clearly identified. biophysical characterization of some of these complexes using circular dichroism and size exclusion chromatography, c ... | 2010 | 20153432 |
| [primary hyperhidrosis. current status of surgical treatment]. | primary hyperhidrosis-ph is an excessive sweating without known etiology. the ph is more frequent in women and in palms, soles and axillae. medical treatment is not effective. the objective of the surgery is to remove or to disconnect sympathetic ganglia t2 (craniofacial ph or facial blushing), t3 (palmar ph) and t3-t4 (axillary ph). the surgical techniques are mainly resection/transection, ablation with electrocoagulation, sympathetic block by clipping and radiofrequency. anhidrosis is achieved ... | 2010 | 20153461 |
| cytotoxic proteins of amanita virosa secr. mushroom: purification, characteristics and action towards mammalian cells. | a new hemolytic lectin was purified from the fruit bodies of amanita virosa secr. mushroom by the affinity chromatography on the cross-linked ovomucin. this lectin destroyed erythrocytes of human and animals of various species, and its hemolytic activity decreased in the row: rabbit > rat > human > dog. the erythrocytes of sheep, cow and carp were resistant to such hemolytic action of the lectin (1 mg/ml). the lectin-mediated hemolysis was blocked by the polyethylene glycol with molecular mass o ... | 2010 | 20153765 |