Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| pedicle screw-only constructs with lumbar or pelvic fixation for spinal stabilization in patients with duchenne muscular dystrophy. | retrospective case study. | 2009 | 19652570 |
| straight midline mandibulotomy: technique and results of treatment. | mandibulotomy is an important surgical approach to tumors of the oral cavity and oropharynx. however the approaches and complications associated with this procedure varies in many studies. | 2007 | 19652672 |
| a retrospective comparison of clinical outcomes and quality of life measures between definitive chemoradiation alone and radical surgery for clinical stage ii-iii esophageal carcinoma. | this retrospective study was conducted to compare the treatment and quality of life (qol) results between radical surgery and definitive chemoradiotherapy (crt) for stage ii-iii carcinoma of the esophagus. | 2009 | 19653240 |
| salvage esophagectomy after definitive chemoradiotherapy for thoracic esophageal cancer. | although locoregional failure frequently occurs after definitive chemoradiotherapy (crt), the role of salvage esophagectomy has not been fully evaluated. the aim of this study was to compare the outcome of salvage esophagectomy after high-dose definitive crt with neoadjuvant crt. | 2009 | 19653262 |
| introduction of the 7th edition eyelid carcinoma classification system from the american joint committee on cancer-international union against cancer staging manual. | the american joint committee on cancer (ajcc) and the international union against cancer commissioned the ophthalmic oncology task force to modify and update the ophthalmic chapters of the 7th edition of the ajcc cancer staging manual. | 2009 | 19653721 |
| the water-soluble roussin's red ester acting as a potential photochemical no-delivery agent: photolysis reactions, dna cleavage and anticancer activity. | the water-soluble roussin's red ester [(no)(2)fe(mu-sch(2)ch(2)p(o)(ch(2)oh)(2))(2)fe(no)(2)] (1), a potential photochemical prodrug of an no precursor, was synthesized from the reaction of hsch(2)ch(2)p(o)(ch(2)oh)(2) (f) and [fe(co)(2)(no)(2)]. the ir v(no) stretching frequencies of complex 1 appear at 1759 (s), 1784 (s) and 1816 (w) cm(-1) in buffer (ph = 7.4). no was released with a stoichiometry ratio delta[no]/delta[1] = 3.6 +/- 0.2 when complex 1 was exposed to uv in deaerated aqueous pho ... | 2009 | 19655074 |
| cd3+ cells at the invasive margin of deeply invading (pt3-t4) colorectal cancer and risk of post-surgical metastasis: a longitudinal study. | the density of tumour-infiltrating lymphocytes (til) has been proposed as an independent predictor of outcome in patients with colorectal cancer. however, the relative roles of til density, nodal status, and microsatellite instability (msi) in predicting tumour progression to metachronous metastasis remain to be elucidated. the aim of this study was to assess the relationship between the density of cd3+ til and the postsurgical occurrence of distant-organ metastases in a large series of patients ... | 2009 | 19656725 |
| enhancing muscular qualities in untrained women: linear versus undulating periodization. | this study compared linear (lp) and undulating periodization (up) on strength changes in untrained women when total workload and average training intensity were matched by the end of training. | 2009 | 19657289 |
| improved endothelial function and lipid profile compensate for impaired hemostatic and inflammatory status in iatrogenic chronic subclinical hyperthyroidism of thyroid cancer patients on l-t4 therapy. | we aimed to compare the changes of endothelial function and haemostatic, inflammatory and metabolic parameters of short-term iatrogenic hypothyroidism to the characteristics of subclinical hyperthyroidism in patients with differentiated thyroid cancer. | 2010 | 19658059 |
| laparoscopic radical nephrectomy for renal masses 7 centimeters or larger. | to report our operative experience and oncologic outcomes for the laparoscopic management of large renal tumors. | 2009 | 19660207 |
| [optimal method for rat skeletal muscle decellularization]. | to investigate an optimal method for sd rat skeletal muscle decellularization. | 2009 | 19662989 |
| hyperfractionated radiotherapy: improvement of survival in locally advanced nasopharyngeal carcinoma. | standard treatment with concomitant chemotherapy (ct) and radiotherapy (rt) for nasopharyngeal cancer has shown rates of locoregional control of 80% and has improved the rate of 5-year survival to 67% to 84%. hyperfractionated radiotherapy (hfrt) may increase locoregional control of tumors of the head and neck, but the addition of concomitant ct involves an unacceptable level of toxicity. adding induction ct may control distant metastasis. here we compare the results of our protocol with inducti ... | 2009 | 19663376 |
| use of stabilizing mutations to engineer a charged group within a ligand-binding hydrophobic cavity in t4 lysozyme. | both large-to-small and nonpolar-to-polar mutations in the hydrophobic core of t4 lysozyme cause significant loss in stability. by including supplementary stabilizing mutations we constructed a variant that combines the cavity-creating substitution leu99 --> ala with the buried charge mutant met102 --> glu. crystal structure determination confirmed that this variant has a large cavity with the side chain of glu102 located within the cavity wall. the cavity includes a large disk-shaped region plu ... | 2009 | 19663503 |
| bladder neck involvement as pt4 disease in prostate cancer: implications for prognosis and patient surveillance. | since the use of prostate-specific antigen screening has become widespread, prostate cancer at clinical t4 stage has become rare. most bladder invasion is actually detected on radical prostatectomy specimens as a microscopic bladder neck involvement (bni). the 2002 tnm classification system classified prostate cancer with bni within a unified pt4 category, and rendered it equivalent to invasion into pelvic wall musculature or external sphincter. this decision is controversial. various series hav ... | 2009 | 19663730 |
| high 2-[18f]fluoro-2-deoxy-d-glucose (18fdg) uptake measured by positron emission tomography is associated with reduced overall survival in patients with oral squamous cell carcinoma. | patients with oral squamous cell carcinoma (oscc) and poor prognosis may benefit from an intensification of the initial therapy scheme. to improve the clinical management of these patients, there is a strong requirement for an accurate assessment of the malignant properties of the individual lesion. the objective of the present analysis was to define the potential value of 2-[(18)f]fluoro-2-deoxy-d-glucose ((18)fdg) uptake in the tumor measured by positron emission tomography (pet) in predicting ... | 2009 | 19665923 |
| effect of combination therapy with thyroxine (t4) and 3,5,3'-triiodothyronine versus t4 monotherapy in patients with hypothyroidism, a double-blind, randomised cross-over study. | treatment of hypothyroidism with 3,5,3'-triiodothyronine (t(3)) is controversial. a recent meta-analysis concludes that no evidence is present in favour of using t(3). however, the analysis included a mixture of different patient groups and dose-regimens. | 2009 | 19666698 |
| bacteriophage t4 endonuclease ii, a promiscuous giy-yig nuclease, binds as a tetramer to two dna substrates. | the oligomerization state and mode of binding to dna of the giy-yig endonuclease ii (endoii) from bacteriophage t4 was studied using gel filtration and electrophoretic mobility shift assays with a set of mutants previously found to have altered enzyme activity. at low enzyme/dna ratios all mutants except one bound to dna only as tetramers to two dna substrates. the putatively catalytic e118 residue actually interfered with dna binding (possibly due to steric hindrance or repulsion between the gl ... | 2009 | 19666720 |
| effectiveness of sympathetic block by clipping in the treatment of hyperhidrosis and facial blushing. | main cause of dissatisfaction after videothoracoscopic (vats) sympathectomy in the treatment of hyperhidrosis (hh) and facial blushing (fb) is compensatory sweating (cs). sympathetic nerve (sn) clipping permits to revert the block effect by removing the clips in case of an intolerable cs. we present our experience with this technique. sixty-one patients diagnosed for hh and/or fb were operated on vats sn clipping. clipping levels varied in function for the sort of disease: fb: t2, palmar hh: t3, ... | 2009 | 19666953 |
| [can ft3 levels facilitate the detection of inflammation or catabolism and malnutrition in dialysis patients?]. | low serum free triiodothyronine (ft3) levels have been reported in a high percentage of chronic renal failure (crf) patients and have been considered as independent predictors of mortality in both hemodialysis (hd) and peritoneal dialysis (pd). a reduction in thyroid function in dialysis patients could be a marker of malnutrition and/or inflammation. | 2009 | 19668301 |
| male breast cancer in tripoli, libya. | to study the epidemiology, characteristics, and survival of male breast cancer patients. | 2009 | 19668888 |
| gain of new exons and promoters by lineage-specific transposable elements-integration and conservation event on chrm3 gene. | the chrm3 gene is a member of the muscarinic acetylcholine receptor family that plays important roles in the regulation of fundamental physiological functions. the evolutionary mechanism of exon-acquisition and alternative splicing of the chrm3 gene in relation to transposable elements (tes) were analyzed using experimental approaches and in silico analysis. five different transcript variants (t1, t2, t3, t3-1, and t4) derived from three distinct promoter regions (t1: l1hs, t2, t4: original, t3, ... | 2009 | 19669628 |
| [clinical review of supracricoid laryngectomy with chep and chp: 50 patients treated in 11 years]. | an analysis of clinical data on 50 patients undergoing supracricoid laryngectomy (scl) between 1997 and 2008 i.e., cricohyoidoepiglottopexy (chep) in 47 and cricohyoidopexy (chp) in 3 cases showed that the number of scl cases operated on within a year surpassed that of total laryngectomy after 2003. selection criteria included performance status 0-1 and blood gas po2>80 torr, especially in those patients over 70-years-old. postoperative wound infection occurred in 16 patients (32%), with four re ... | 2009 | 19670796 |
| mechanism of thermal renaturation and hybridization of nucleic acids: kramers' process and universality in watson-crick base pairing. | renaturation and hybridization reactions lead to the pairing of complementary single-stranded nucleic acids. we present here a theoretical investigation of the mechanism of these reactions in vitro under thermal conditions (dilute solutions of single-stranded chains, in the presence of molar concentrations of monovalent salts and at elevated temperatures). the mechanism follows a kramers' process, whereby the complementary chains overcome a potential barrier through brownian motion. the barrier ... | 2009 | 19673131 |
| exploitation of a new flagellatropic phage of erwinia for positive selection of bacterial mutants attenuated in plant virulence: towards phage therapy. | to isolate and characterize novel bacteriophages for the phytopathogen, erwinia carotovora ssp. atroseptica (eca), and to isolate phage-resistant mutants attenuated in virulence. | 2010 | 19674185 |
| diagnostic spectrum of congenital hypothyroidism in turkish children. | congenital hypothyroidism (ch) is classified as transient or permanent. transient ch can be treated with short-term thyroxine replacement therapy or followed up without therapy, whereas lifelong thyroxine replacement is needed in permanent ch. determination of the underlying etiology is essential for determination of follow-up strategy. the purpose of the present study was therefore to assess the role of color doppler ultrasonography (cdu) in etiologic diagnosis of ch together with radionuclide ... | 2009 | 19674358 |
| effects of reduced training and detraining on upper and lower body explosive strength in adolescent male basketball players. | the purpose of this study was to assess and compare the effects of detraining and of a reduced training program on upper- and lower-body explosive strength in adolescent male basketball players. to study this, 15 subjects, aged 14 to 15 years old, were randomly assigned to 1 of the 2 following groups: reduced training (rt; n = 8) and detraining (dtr; n = 7). the participants were assessed on squat jump (sj), countermovement jump (cmj), abalakov test (aba), depth jump (dj), mechanical power (mp), ... | 2009 | 19675489 |
| effects of the electromagnetic field, 60 hz, 3 microt, on the hormonal and metabolic regulation of undernourished pregnant rats. | epidemiological studies have implicated maternal protein-calorie deficiency as an important public health problem in developing countries. over the last decades, a remarkable diffusion of electricity and an increased level of the electromagnetic field (emf) in the environment have characterized modern societies. therefore, researchers are concerned with the biological effects of 50-60 hz, emf. the aim of this paper is to show the effects of emf of 60 hz, 3 mut, exposure for two hours per day in ... | 2009 | 19675945 |
| detailed examination of lymph nodes improves prognostication in colorectal cancer. | up to 30% of stage ii patients with curatively resected colorectal cancer (crc) will develop disease recurrence. we evaluated whether examination of lymph nodes by multilevel sectioning and immunohistochemical staining can improve prognostication. lymph nodes (n = 780) from 36 crc patients who had developed disease recurrence (cases) and 72 patients who showed no recurrence of disease for at least 5 years (controls) were analyzed. sections of 4 levels at 200-microm interval were immunohistochemi ... | 2010 | 19676050 |
| relationship between historical height loss and vertebral fractures in postmenopausal women. | the aim of this study was to evaluate the relationship between historical height loss (hhl) and prevalent vertebral fractures (vf) in postmenopausal moroccan women and to estimate its accuracy as a clinical test for detecting vf. two hundred eighty-eight postmenopausal women were studied. all subjects had bone density measurements and spinal radiographs. vertebral bodies (t4-l4) were graded using the semi-quantitative method of genant. hhl was calculated as the difference between a patient's tal ... | 2009 | 19680590 |
| [nutritional status of patients with cancer of larynx and hypopharyx]. | the meaning of proper nutritional state in the group of cancer patients in preoperative period was noticed already over 40 years ago. in spite, that treatment of malnutrition is easy, many patients are not diagnosed and not treated, what has obvious consequences. the aim of this study was to evaluate nutritional status of patients with cancer of larynx and hypopharynx before the treatment. | 2009 | 19681485 |
| study of the transport of thyroid hormone by transporters of the slc10 family. | transport of (sulfated) iodothyronines across the plasma membrane is required for their intracellular metabolism. rat na(+)/taurocholate cotransporting polypeptide (ntcp; slc10a1) has been identified as an important transporter protein. we demonstrate that among the 7 members of the solute carrier family slc10, only human slc10a1 mediates sodium-dependent transport of the iodothyronine t4 and iodothyronine sulfates t3s and t4s. in contrast to slc10a2-7, cells co-expressing slc10a1 and the deiodi ... | 2010 | 19682536 |
| changes in thyroid hormone reception precede sws1 opsin downregulation in trout retina. | rainbow trout undergo natural cone degeneration and thus are interesting models for examining mechanisms of neural degeneration. they have ultraviolet-sensitive (uvs) cones that are lost over most of the retina during development; only a small functional population remains in the dorsal retina. how this spatial distribution of uvs cones is maintained is unclear. thyroxine (t4) induces uvs cone loss, and local thyroid hormone regulation was hypothesized to control uvs cone distribution. thyroid h ... | 2009 | 19684211 |
| microvascular flap reconstruction of major pharyngeal resections with the intent of laryngeal preservation. | to determine the functional outcome in patients undergoing pharyngeal reconstruction with free tissue transfer with the intent of functional laryngeal preservation. | 2009 | 19687402 |
| [diagnosis of and therapy for gastric cancer--work-flow]. | this review comments on the diagnosis and treatment of gastric cancer in the classical meaning--excluding adenocarcinoma of the -oesophagogastric junction. algorithms of diagnosis and care with respect to tumour stage are presented. preoperative diagnosis: besides oesophagogastroduodenoscopy, endoscopic ultrasonography is necessary for the accurate diagnosis of t categories and as a selection criterion for neoadjuvant chemotherapy. computed tomography is recommended for preoperative evaluation o ... | 2009 | 19688686 |
| boron mimetics: 1,2-dihydro-1,2-azaborines bind inside a nonpolar cavity of t4 lysozyme. | 2009 | 19688806 | |
| the challenge of culturing human colorectal tumor cells: establishment of a cell culture model by the comparison of different methodological approaches. | because colorectal cancer is a significant cause of morbidity and mortality in the western population, knowledge of the molecular and biological alterations associated with its development is important. since primary human colon cancer cultures from fresh tumor tissue are technically difficult to obtain, experiments in most laboratories are performed on colon epithelial cell lines, but these represent just one stage of tumor progression. only primary cultures of neoplastic colonocytes may reflec ... | 2009 | 19688974 |
| gastric cancer: correlation between clinicopathological factors and survival of patients (iii). | the purpose of this study was to identify the clinicopathological factors that influence the prognosis of patients having undergone surgery for gastric cancer. the analysis of the potential prognosis factors has included in this study parameters concerning the patient (sex, age), as well as parameters related with the tumor (histological type according to the who classification; degree of tumor differentiation; tumor location; stage of disease; pt and pm parameters according to the tnm classific ... | 2009 | 19690762 |
| prevalence of anterior pituitary dysfunction in patients following traumatic brain injury in a german multi-centre screening program. | we determined the prevalence of anterior pituitary dysfunction in a multi-centre screening program across five german endocrine centres in patients rehabilitating from tbi (gcs<13). | 2010 | 19691014 |
| why are pretreatment prostate-specific antigen levels and biochemical recurrence poor predictors of prostate cancer survival? | the value of pretreatment (initial) prostate-specific antigen (ipsa) and biochemical recurrence (br) as prognostic factors for survival remains unclear. the authors sought to determine why using randomized trial data with 7-year minimum follow-up. | 2009 | 19691097 |
| impact of demographics, tumor characteristics, and treatment factors on swallowing after (chemo)radiotherapy for head and neck cancer. | this prospective study evaluated the impact of patient demographics, tumor characteristics, and radiotherapy treatment on swallowing before and after radiotherapy or chemoradiotherapy. | 2010 | 19691115 |
| recombination and microdiversity in coastal marine cyanophages. | genetic exchange is an important process in bacteriophage evolution. here, we examine the role of homologous recombination in the divergence of closely related cyanophage isolates from natural marine populations. four core-viral genes (coliphage t4 homologues g20, g23, g43 and a putative tail fibre gene) and four viral-encoded bacterial-derived genes (psba, psbd, cobs and phoh) were analysed for 60 cyanophage isolates belonging to five rhode island myovirus (rim) strains. phylogenetic analysis o ... | 2009 | 19691502 |
| recommended changes for t and n descriptors proposed by the international association for the study of lung cancer - lung cancer staging project: a validation study from a single-centre experience. | the international association for the study of lung cancer (iaslc) recently recommended changes for t and n descriptors for the next tnm (tumour, node, metastasis) edition. we re-classify our operated patients to evaluate the effectiveness of the iaslc suggestions. | 2009 | 19692259 |
| applicability of the revised international association for the study of lung cancer staging system to operable non-small-cell lung cancers. | a new staging system for lung cancer has been proposed by the international association for the study of lung cancer staging committee. we assessed the feasibility of this system for surgical patients. | 2009 | 19692261 |
| the effect of prehabilitation exercise on strength and functioning after total knee arthroplasty. | the purpose of this study was to examine the effect of a preoperative exercise intervention on knee pain, functional ability, and quadriceps strength among patients with knee osteoarthritis before and after total knee arthroplasty (tka) surgery. | 2009 | 19695525 |
| [gallbladder cancer in a regional hospital]. | to assess the management of gallbladder cancer (gbc) in our region. | 2009 | 19695566 |
| predictors of peritoneal carcinomatosis in patients with gastric cancer treated at a single institution in brazil. | peritoneal carcinomatosis is a common pattern of recurrence in gastric cancer and is associated with a poor prognosis. determining predictive factors for peritoneal recurrence can help the selection of patients suitable for more aggressive treatment strategies. | 2009 | 19697363 |
| [properties of metabolic substance produced by group a streptococcus from two food-borne epidemic]. | we report the finding for two food-poisonins outbreaks occurring in tokyo and chiba in september 2003. patients in the tokyo outbreak suffered from fever varying widely from 35.9 degrees c to 39.4 degrees c. throat pain was predominant, accompanied by headache, cough, and joint pain. patients in the chiba outbreak suffered from malaise in addition to the above symptoms. to clarify the relationship between pathology and virulence factors, we studied the properties of hemolysins and proteases prod ... | 2009 | 19697874 |
| ideology and ethics. the perversion of german psychiatrists' ethics by the ideology of national socialism. | as soon as adolf hitler came to into power in 1933, four laws on racial segregation and race protection were edicted between 1934 and 1935. schizophrenia, manic-depressive psychoses, epilepsy and alcoholism were regarded as hereditary mental illnesses. these laws were responsible for the sterilisation of 350,000 individuals who were thought to be at the source of the propagation of hereditary illnesses which might endanger the health and the future of the aryan germans. on september 1, 1939, act ... | 1998 | 19698678 |
| effect of sympathectomy level on the incidence of compensatory hyperhidrosis after sympathectomy for palmar hyperhidrosis. | palmar hyperhidrosis can be psychosocially devastating. sympathectomy provides effective treatment. the most common side effect after sympathectomy is compensatory hyperhidrosis, which can be debilitating. controversy exists as to which and how many levels treated carry the lowest incidence of compensatory hyperhidrosis after sympathectomy for palmar hyperhidrosis. | 2009 | 19698838 |
| hypoxia in larynx carcinomas assessed by pimonidazole binding and the value of ca-ix and vascularity as surrogate markers of hypoxia. | tumour hypoxia as driving force in tumour progression and treatment resistance has been well established. assessment of oxygenation status of tumours may provide important prognostic information and improve selection of patients for treatment. in this study, a large homogenous group of 103 laryngeal carcinomas has been investigated in the presence of hypoxia by pimonidazole binding and the usefulness of carbonic anhydrase ix (ca-ix) and vascular parameters as surrogate markers of hypoxia. these ... | 2009 | 19699082 |
| in vivo replication of t4 and t7 bacteriophages in germ-free mice colonized with escherichia coli. | the gut transit of t4 phages was studied in axenic mice mono-colonized with the non-pathogenic escherichia coli strain k-12. thirty minutes, 1 and 2 h after phage feeding, t4 phage had reached the jejunum, ileum and cecum, respectively. phage was found in the lumen and was also associated with the mucosa. one day later no phage was detected in the feces. compared to germ-free control animals, oral t4 phage led to a 300-fold higher fecal phage titer in mice mono-colonized with e. coli strain wg-5 ... | 2009 | 19699505 |
| investigation of stoichiometry of t4 bacteriophage helicase loader protein (gp59). | the t4 bacteriophage helicase loader (gp59) is one of the main eight proteins that play an active role in the replisome. gp59 is a small protein (26 kda) that exists as a monomer in solution and in the crystal. it binds preferentially to forked dna and interacts directly with the t4 helicase (gp41), single-stranded dna-binding protein (gp32), and polymerase (gp43). however, the stoichiometry and structure of the functional form are not very well understood. there is experimental evidence for a h ... | 2009 | 19700405 |
| expression of trpc6 in benign and malignant human prostate tissues. | we investigated the expression of transient receptor potential canonical 6 (trpc6) protein in benign and malignant human prostate tissues and in prostate cancer cell lines and the association with the stage, grade and androgen responsiveness of the tumors. immunohistochemical techniques, western blot and reverse transcription polymerase chain reaction (rt-pcr) were used to investigate trpc6 expression. trpc6 protein was detected in 9 of 20 (45.0%) of benign prostatic hyperplasia (bph) cases, and ... | 2009 | 19701218 |
| [effect of shenfu injection on the stability of circulation during induction of general anesthesia for aged people]. | to observe the intervention of shenfu injection (sfi) on the hemodynamics and circulatory function during induction of general anesthesia for aged people, in order to optimize the medication of anesthesia inductive phase in aged people. | 2009 | 19702078 |
| [effects of preconditioning and postconditioning with shenfu injection on cognitive function in patients after valve replacement under cardiopulmonary bypass]. | to investigate the effects of preconditioning and postconditioning with shenfu injection (sfi) on cognitive function in patients after valve replacement under extra-corporeal circulation. | 2009 | 19702079 |
| definitive radiotherapy for squamous cell carcinoma of the anal canal. | to review the outcomes of definitive radiotherapy (rt) alone or combined with chemotherapy (ct) in the treatment of squamous cell carcinoma of the anal canal. | 2010 | 19704368 |
| evaluation of small ligand-protein interaction by ligation reaction with dna-modified ligand. | a method for the evaluation of interactions between protein and ligand using dna-modified ligands, including signal enhancement of the dna ligation reactions, is described. for proof of principle, a dna probe modified by biotin was used. two dna probes were prepared with complementary sticky-ends. while one dna probe was modified at the 5'-end of the sticky-end, the other was not modified. the probes could be ligated together by t4 dna ligase along the strand without biotin modification. however ... | 2010 | 19705069 |
| factors correlated with peritoneal carcinomatosis and survival in patients with gastric cancer treated at a single institution in brazil. | gastric cancer is the second leading cause of death due to cancer worldwide and is particularly prevalent in brazil. promising new therapeutic agents have already shown activity in some gastrointestinal malignancies and their role in gastric cancer will need to be evaluated. determining the prognostic factors of survival for patients with gastric cancer can help in identifying patients with a worse prognosis after treatment with the current chemotherapeutic regimens. | 2009 | 19705243 |
| relationships of serum free thyroxine and erythrocyte measures in euthyroid hfe c282y homozygotes and control subjects: the heirs study. | hemoglobin (hb) levels and mean corpuscular volume (mcv) are abnormal in some persons with hemochromatosis or thyroid disorders. we sought to determine whether serum free thyroxine (t4) affects erythrocyte measures in euthyroid adults with or without c282y homozygosity. we evaluated 488 white hfe c282y homozygotes and controls (no hfe c282y or h63d; normal serum iron measures) identified in screening; we excluded those with thyroid disorders, anemia, erythrocytosis, or serum ferritin (sf) <34 pm ... | 2010 | 19706067 |
| selenium and thyroid autoimmunity. | the trace element selenium (se) occurs in the form of the amino acid selenocysteine in selenoproteins. selenoproteins exerts multiple physiological effects in human health, many of which are related with regulation of reduction-oxidation processes. in fact, the selenoenzyme families of glutathione peroxidase (gpx) and thioredoxin reductase (trx) display the ability to act as antioxidants, protecting cells from oxidative damage. furthermore, another class of selenoproteins are the iodothyronine d ... | 2008 | 19707359 |
| adjuvant treatment with thyrotropin alpha for remnant ablation in thyroid cancer. | various studies have demonstrated the safety and efficacy of recombinant human thyroid-stimulating hormone (rhtsh) for radioiodine remnant ablation. on this basis, rhtsh was approved in europe for the radioiodine ablation of low-risk differentiated thyroid cancer (dtc) during thyroid hormone therapy with l-thyroxine (l-t4). moreover, in december 2007, the us federal drug administration approved the use of rhtsh for adjuvant treatment with radioiodine in patients with dtc without evidence of meta ... | 2009 | 19707391 |
| prognosis of pn3 stage gastric cancer. | the aim of this study was to determine the prognosis of pn3 stage gastric cancer patients after they have undergone curative resection, and we also wanted to identify the prognostic factors according to the clinico-pathologic features. | 2009 | 19707504 |
| non-canonical rna arrangement in t4-even phages: accommodated ribosome binding site at the gene 26-25 intercistronic junction. | translational initiation region of bacteriophage t4 gene 25 contains three potential shine and dalgarno sequences: sd1, sd2 and sd3. mutational analysis has predicted that an mrna stem-loop structure may include sd1 and sd2, bringing the most typical sequence sd3, gagg, to the initiation codon. here, we report physical evidence demonstrating that previously predicted mrna stem-loop structure indeed exists in vivo during gene 25 expression in t4-infected escherichia coli cells. the second mrna st ... | 2009 | 19708923 |
| contemporary risk profile of prostate cancer in the united states. | national-level data that characterize contemporary prostate cancer patients are limited. we used 2004-2005 data from the surveillance, epidemiology, and end results program to generate a contemporary profile of prostate cancer patients (n = 82 541) and compared patient characteristics of this 2004-2005 population with those of patients diagnosed in 1998-1989 and 1996-1997. among newly diagnosed patients in 2004-2005, the majority (94%) had localized (ie, stage t1 or t2) prostate cancer and a med ... | 2009 | 19713548 |
| [severe pulmonary hypertension and congestive heart failure in an elderly patient with basedow's disease]. | an 83-year-old woman was admitted to our hospital with dyspnea. a chest x-ray showed cardiomegaly and pulmonary congestion. an echocardiogram revealed severe tricuspid regurgitation and markedly elevated transtricuspid pressure gradient of 103 mmhg. there was no left ventricular systolic or diastolic dysfunction. laboratory evaluation revealed elevated free t4 and suppressed tsh levels. serum level of anti-tsh receptor antibody was significantly elevated. a thyroid echogram demonstrated increase ... | 2009 | 19713670 |
| detection of functional modes in protein dynamics. | proteins frequently accomplish their biological function by collective atomic motions. yet the identification of collective motions related to a specific protein function from, e.g., a molecular dynamics trajectory is often non-trivial. here, we propose a novel technique termed "functional mode analysis" that aims to detect the collective motion that is directly related to a particular protein function. based on an ensemble of structures, together with an arbitrary "functional quantity" that qua ... | 2009 | 19714202 |
| molecular biology and biotechnology of bacteriophage. | the development of the molecular biology of bacteriophage such as t4, lambda and filamentous phages was described and the process that the fundamental knowledge obtained in this field has subsequently led us to the technology of phage display was introduced. | 2010 | 19714316 |
| effects of chronic estradiol treatment on the thyroid gland structure and function of ovariectomized rats. | estrogen therapy is widely used nowadays in women to treat many postmenopausal symptoms but it may have some undesirable effects due to multiple organs affection. so, the aim of this study was to determine the effects of chronic estradiol treatment on the structure and function of the thyroid gland in ovarictomized rats as a model simulating menopause. | 2009 | 19715616 |
| staging and survival for sinus cancer in the pediatric population. | to determine histology, staging, and survival for pediatric sinus cancer. | 2009 | 19720405 |
| presence of intratumoral neutrophils is an independent prognostic factor in localized renal cell carcinoma. | we have previously demonstrated a significant negative impact of intratumoral neutrophils in metastatic renal cell carcinoma. this study assessed intratumoral neutrophils in localized clear cell renal cell carcinoma (rcc). | 2009 | 19720929 |
| lack of a co-promotion effect of 60 hz circularly polarized magnetic fields on spontaneous development of lymphoma in akr mice. | the present study was conducted to investigate the possible effect of 60 hz circularly polarized magnetic fields (mfs) as promoters of genetically initiated lymphoma in akr mice. one hundred sixty female animals were divided into four different groups. they were exposed to four different intensities of circularly polarized mfs. animals received exposure to 60 hz circularly polarized mf at field strengths (rms-value) of 0 microt (sham control, t1, group i), 5 microt(t2, group ii), 83.3 microt (t3 ... | 2010 | 19722221 |
| tumor proteomic profiling predicts the susceptibility of breast cancer to chemotherapy. | chemotherapy is often used for breast cancer treatment, but individual outcome varies widely. we hypothesized that tumor proteomic profiles obtained prior to chemotherapy may predict the individual tumor response to treatment. the goal of our study was to explore feasibility of using proteomic profiling to preselect patients for an effective chemotherapeutic regimen. tumors from 52 patients with t2-t4 breast cancer were prospectively collected before neoadjuvant chemotherapy, and were analyzed u ... | 2009 | 19724903 |
| [efficacy of sugammadex in the reversal of neuromuscular blockade induced by rocuronium in long-duration surgery: under inhaled vs. intravenous anesthesia]. | sugammadex reverses neuromuscular blockade induced by aminosteroid agents by encapsulating these agents. the objective of this study was to compare the efficacy and safety of sugammadex to reverse a rocuronium-induced neuromuscular blockade in long-duration surgery in association with inhaled or intravenous anesthesia. | 2009 | 19725342 |
| assessment of left ventricular systolic asynchrony in patients with clinical hypothyroidism. | hypothyroidism has a large number of adverse effects on the cardiovascular system such as impaired cardiac contractility. left ventricular (lv) asynchrony is defined as loss of the simultaneous peak contraction of corresponding cardiac segments. | 2010 | 19725846 |
| protease supplementation improves muscle function after eccentric exercise. | protease supplementation has been purported to reduce the damaging effects of eccentric exercise and accelerate recovery of muscle function, possibly by regulating inflammation. | 2009 | 19727022 |
| far field potentials from brain stem after transcutaneous vagus nerve stimulation: optimization of stimulation and recording parameters. | the method of vagus somatosensory evoked potentials (vsep) was introduced to easily measure the activity of vagus brain stem nuclei. in alzheimer's disease, this measure was characterized by longer latencies as compared to controls while amplitudes did not show statistical significant differences at frontal and central recording sites. therefore, the influence of stimulation and recording parameters on amplitudes of vsep were systematically examined. in 20 healthy participants, vsep measurement ... | 2009 | 19728032 |
| short oligonucleotide tandem ligation assay for genotyping of single-nucleotide polymorphisms in y chromosome. | we propose a novel universal methodology, short oligonucleotide tandem ligation assay (sotla), for snp genotyping. sotla is based on using a tandem of short oligonucleotide (tso) probes consisting of three fragments: the core oligonucleotide and two flanking oligomers, one of which is immobilized onto a solid support and another one contains the biotin label. tso is self-associated on a complementary dna template, forms the complex containing two nicks, which are efficiently ligated with dna lig ... | 2010 | 19728184 |
| abnormal responses to trh in children born small for gestational age that failed to catch up. | fifteen percent of small for gestational age (sga) children remain short and undergo thyroid axis evaluations. | 2009 | 19729948 |
| pilot test of the salt mass casualty triage system. | no existing mass casualty triage system has been scientifically scrutinized or validated. a recent work group sponsored by the centers for disease control and prevention, using a combination of expert opinion and the extremely limited research data available, created the salt (sort-assess-lifesaving interventions-treat/transport) triage system to serve as a national model. an airport crash drill was used to pilot test the salt system. | 2009 | 19731169 |
| deconjugation of thyroxine glucuronide by the rat kidney. | rapid deconjugation of administered thyroxine glucuronide (t4g) to thyroxine (t4) has been observed in human subjects. the goal of this study was to characterize, in the rat, the location and kinetics of this deconjugation process and to identify whether early conjugation of t4 to t4g occurs in the liver. | 2009 | 19731980 |
| [magnetic resonance imaging in the preoperative staging of rectum cancer]. | the treatment of rectum cancer depends on the tumour stage, and until 2005 treatment included preoperative radiation therapy for the t3 and t4 cancer stages. an exact preoperative assessment of the cancer stage is therefore essential. in denmark rectal magnetic resonance imaging (mri) is used as a standard procedure in preoperative evaluation, sometimes supplemented by transrectal ultrasound (trus). the purpose of this study was to determine the accuracy of preoperative mri in tumour stage evalu ... | 2009 | 19732535 |
| interstitial brachytherapy as boost for locally advanced t4 head and neck cancer. | locally advanced squamous cell cancers of the head and neck (scchn) with bone and cartilage invasion (bci) or those with soft-tissue invasion (sti) have been treated with resection followedup with chemoradiotherapy (crt) or definitive crt. however, locoregional recurrence remained a large component of treatment failure. high-dose-rate interstitial brachytherapy (bt) has been used for dose escalation to further prevent local relapse. this is a review of our experience. | 2009 | 19733128 |
| inhibitory effect of aluminium on calcium absorption in small intestine of rats with different thyroid hormone status. | to analyse the influence of thyroid status on the effect of aluminium (al) upon intestinal calcium (ca) absorption, adult male wistar rats with experimentally altered thyroid hormones circulating levels, were orally treated (o.g.) with 0 (control), or 50 mg elemental al (as chloride)/kg body weight (b.w.) per day, for a 14 d period. hyper- and hypo-thyroid conditions were respectively achieved by means of administration of either sodium levothyroxine (50 microg/kg b.w. per day, o.g.) or methimaz ... | 2009 | 19733399 |
| initial management of prostate cancer: first year experience with the norwegian national prostate cancer registry. | study type - therapy (individual cohort) level of evidence 2b | 2010 | 19735258 |
| external radiotherapy for prostate cancer with or without androgen deprivation: geneva, 1991 to 2004. | questions under study/principles: a retrospective assessment of long-term results on a single centre, single author experience in treating prostate cancer with high dose curative radiotherapy (rt) with or without androgen deprivation (ad). | 2009 | 19736590 |
| antimicrobial peptides derived from goose egg white lysozyme. | peptide fragments possessing antimicrobial activity were obtained by protease digestion of goose egg white lysozyme. digested peptide purified from rp-hplc which showed no lysozyme activity exhibited bactericidal activity toward gram-negative and gram-positive bacteria. lc/ms-ms and automated edman degradation revealed the amino acid sequence to be thr-ala-lys-pro-glu-gly-leu-ser-tyr. this sequence corresponds to amino acid positions 20-28, located at the n-terminal outer part of goose lysozyme. ... | 2010 | 19737628 |
| pattern of use of adjuvant chemotherapy for stage ii colon cancer: a single-institution experience. | american society of clinical oncology (asco) guidelines define high-risk prognostic features (hrfs) in stage ii colon cancer and recommend limiting adjuvant chemotherapy to patients with hrfs. we evaluated the extent to which hrfs influenced decisions on adjuvant chemotherapy before and after publication of the guidelines. | 2009 | 19739270 |
| peripheral blood t4 cell surface ccr5 density as a marker of activity in rheumatoid arthritis treated with anti-cd20 monoclonal antibody. | the chemokine (c-c motif) receptor ccr5 and its ligand ccl5 play key roles in the intra-articular recruitment of peripheral blood mononuclear cells (pbmc) in rheumatoid arthritis (ra). therefore, using quantitative cytofluorometry, we followed t4 cell surface ccr5 density in 27 subjects with ra before and after treatment with the anti-cd20 monoclonal antibody rituximab. we observed low t4 cell surface ccr5 densities before treatment, which correlated positively with disease activity, as determin ... | 2009 | 19740335 |
| population-based studies of antithyroid drugs and sudden cardiac death. | thyroid free t4 is associated with qtc-interval prolongation, which is a risk factor for sudden cardiac death (scd). hyperthyroidism has been associated with scd in case reports, but there are no population-based studies confirming this. the aim was to investigate whether use of antithyroid drugs (as a direct cause or as an indicator of poorly controlled hyperthyroidism) is associated with an increased risk of scd. | 2009 | 19740403 |
| childhood sexual abuse and hypothalamus-pituitary-thyroid axis in postpartum major depression. | the aim of this study was to investigate the association between early life events in women with postpartum major depression and concomitant hypothalamus-pituitary-thyroid axis disturbances (hptd), thyroid dysfunction or presence of thyroid antibodies. | 2010 | 19740549 |
| current management of esophageal squamous-cell carcinoma in japan and other countries. | the incidence of adenocarcinoma of the distal esophagus or esophagogastric junction has increased considerably in western countries during the past 3 decades, whereas the incidence of squamous-cell carcinoma has decreased slightly. in japan, most esophageal cancers are squamous-cell carcinomas. endoscopic examinations are more frequently performed in japan for routine screening and diagnosis and treatment than in other countries, thereby increasing the detection rate of superficial esophageal ca ... | 2009 | 19742141 |
| thyroid hormone interactions with dmpc bilayers. a molecular dynamics study. | the structure and dynamics of thyroxine (t4), distal and proximal conformers of 3',3,5-triiodo-l-thyronine (t3d and t3p), and 3,5-diiodo-l-thyronine (t2) upon interaction with dmpc membranes were analyzed by means of molecular dynamics simulations. the locations, the more stable orientations, and the structural changes adopted by the hormones in the lipid medium evidence that the progressive iodine substitution on the beta ring lowers both the possibility of penetration and the transversal mobil ... | 2009 | 19743839 |
| domain insertion effectively regulates the mechanical unfolding hierarchy of elastomeric proteins: toward engineering multifunctional elastomeric proteins. | the architecture of elastomeric proteins controls fine-tuned nanomechanical properties of this class of proteins. most elastomeric proteins are tandem modular in structure, consisting of many individually folded domains of varying stability. upon stretching, these elements unfold sequentially following a strict hierarchical pattern determined by their mechanical stability, where the weakest element unfolds first and the strongest unfolds last. although such a hierarchical architecture is well-su ... | 2009 | 19746906 |
| changes in the central component of the hypothalamus-pituitary-thyroid axis in a rabbit model of prolonged critical illness. | prolonged critically ill patients reveal low circulating thyroid hormone levels without a rise in thyroid stimulating hormone (tsh). this condition is labeled "low 3,5,3'-tri-iodothyronine (t3) syndrome" or "nonthyroidal illness syndrome (nti)" or "euthyroid sick syndrome". despite the low circulating and peripheral tissue thyroid hormone levels, thyrotropin releasing hormone (trh) expression in the hypothalamus is reduced and it remains unclear which mechanism is responsible. we set out to stud ... | 2009 | 19747372 |
| human prostate fibroblasts induce growth and confer castration resistance and metastatic potential in lncap cells. | the tumor microenvironment is important for progressive and metastatic disease. | 2010 | 19747763 |
| food restriction in young japanese quails: effects on growth, metabolism, plasma thyroid hormones and mrna species in the thyroid hormone signalling pathway. | young birds, in their post-natal growth period, may reduce their growth and metabolism when facing a food shortage. to examine how such responses can be mediated by endocrine-related factors, we exposed japanese quail chicks to food restriction for either 2 days (age 6-8 days) or 5 days (age 6-11 days). we then measured growth and resting metabolic rate (rmr), and circulating 3,3',5-triiodo-l-thyronine (t3) and 3,5,3',5'-tetraiodothyronine (t4) levels as well as expression patterns of genes invo ... | 2009 | 19749098 |
| a paradoxical difference in relationship between anxiety, depression and thyroid function in subjects on and not on t4: findings from the hunt study. | there have been conflicting reports on the relationship between thyroid function and mood between studies in subjects on t4 and the general population not on t4. we investigated this relationship in a large catchment area-based study. | 2009 | 19751298 |
| conformational transition of giant dna in a confined space surrounded by a phospholipid membrane. | it has been established that a long dna molecule exhibits a large discrete conformational change from a coiled state to a highly folded state in aqueous solution, depending on the presence of various condensing agents such as polyamines. in this study, t4 dna labeled with fluorescent dyes was encapsulated in a cell-sized microdroplet covered with a phospholipid membrane to investigate the conformational behavior of a dna molecule in such a confined space. fluorescence microscopy showed that the ... | 2009 | 19751673 |
| effects of short-term hyper- and hypoprolactinaemia on hormones of the pituitary, gonad and -thyroid axis and on semen quality in male beagles. | effects of a short-term hyper- and hypoprolactinaemia on serum concentrations of lh, testosterone and semen quality in six male beagles were investigated. blood samples were collected at 3-day intervals for 12 weeks. the time span was divided into five 3-week periods: pre-treatment, metoclopramide (mcp) treatment (0.2 mg/kg orally three times daily), cabergoline (cab) treatment (5 microg/kg orally once daily), post-treatment 1 and post-treatment 2. in the latter, only semen characteristics were ... | 2009 | 19754595 |
| concordance with nccn colorectal cancer guidelines and asco/nccn quality measures: an nccn institutional analysis. | the national comprehensive cancer network (nccn) outcomes database was created to assess concordance to evidence- and consensus-based guidelines and to measure adherence to quality measures on an ongoing basis. the colorectal cancer database began in 2005 as a collaboration among 8 nccn centers. | 2009 | 19755049 |