Publications

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the integration and excision defect of bacteriophage lambda-dg. 19694904108
two stages in the replication of bacteriophage lambda dna. 19694904393
induction of phage lambda by transferred irradiated coli dna. 19694905437
leakiness of pleiotropic maltose-negative, bacteriophage lambda-resistant mutants of escherichi coli k-12.cultures of escherichia coli k-12 mala(-)lambda(r)gal(-) can be transduced to gal(+) by bacteriophage lambdadg because of leakiness of the lambda(r) phenotype. the efficiency of such transduction is about 10(-5) that of transduction of mal(+)lambda(s) bacteria. leaky cells (lambda(s)phenocopies) adsorb only very few phage particles, and many transductants, therefore, are defective heterogenotes or show integration of the gal(+) gene, which is unaccompanied by lysogenization.19694905538
effect of u.v.-irradiated dna containing 5-bromouracil on reactivation u.v. damage in phage lambda. 19694905876
repression of induction by u.v. of lambda phage by exra mutations in escherichia coli. 19704905952
new mutants of bacteriophage lambda with a specific defect in excision from the host chromosome. 19704907272
integrative and excisive recombination by bacteriophage lambda: evidence for an excision-specific recombination protein. 19704907273
complementation experiments about the q gene of phage lambda. 19704907409
behavior of coliphage lambda in hybrids between escherichia coli and salmonella.salmonella typhosa hybrids able to adsorb lambda were obtained by mating s. typhosa recipients with escherichia coli k-12 donors. after adsorption of wild-type lambda to these s. typhosa hybrids, no plaques or infective centers could be detected. e. coli k-12 gal(+) genes carried by the defective phage lambdadg were transduced to s. typhosa hybrids with hft lysates derived from e. coli heterogenotes. the lysogenic state which resulted in the s. typhosa hybrids after gal(+) transduction differed ...19704908675
regulation of bacteriophage lambda development by gene n: properties of a mutation that bypasses n control of late protein synthesis. 19704909409
deletion mapping of the c3-c2 region of bacteriophage lambda. 19704910435
replication of bacteriophage lambda dna associated with the host cell membrane. 19704910439
induction and multiplication of lambda-phage. iv. the effect of panfuran. 19694911436
properties of phage lambda dna-rna polymerase complexes isolated from escherichia coli (lambda). 19704912207
specialized transduction of galactose by lambda phage from a deletion lysogen. 19704912822
bacteriophage lambda; abortive infection of bacteria lysogenic for phage p2.the efficiency of plating of wild-type lambda on a host lysogenic for p2 is less than 10(-6), and only a small number of infected cells produce progeny phage. lambda can adsorb and inject its dna normally in such cells; the dna can circularize and is not nicked or degraded, but replication is severely impaired. mutants of p2, which as prophages no longer interfere with lambda, have been isolated and found to be recessive to wild type, implying that p2 prophage codes for a diffusible product invo ...19704913204
genetic expression in bacteriophage lambda. 3. inhibition of escherichia coli nucleic acid and protein synthesis during lambda development. 19704916548
behavior of lambda bacteriophage in a recombination deficienct strain of escherichia coli.the behavior of lambda phage in the rec(-) strain jc-1569 is compared with that in the rec(+) strain jc-1557. no difference deemed significant was noted in the adsorption rate, latent period, burst size, frequency of lysogenization, and frequency of vegetative phage recombination. the location of the prophage and its mode of insertion in the rec(-) lysogen of wild-type lambda (lambda(+)) were inferred to be normal from the results of conjugational crosses. spontaneous and ultraviolet (uv) irradi ...19674918235
crypticogenicity of bacteriophage lambda. 19704920426
effect of carbohydrates on induction of bacteriophage lambda. 19704920472
intracellular pools of bacteriophage lambda deoxyribonucleic acid. 19704920498
correlations between host-cell reactivation, ultraviolet reactivation and pyrimidine dimer excision in the dna of bacteriophage lambda. 19704921248
lambda phage transduction of the bio a locus of escherichia coli. 19704921685
reduced immunity in lysogens of bacteriophage lambda due to a mutation in the prophage. 19704921686
unbiased synthesis of pulse-labeled dna framents of bacteriophage lambda and t4. 19704922215
[repression system of bacteriophage lambda and control of gene function]. 19704922246
the morphogenesis of bacteriophage lambda. ii. identification of the principal structural proteins. 19704923012
morphological proteins of phage lambda: identification of the major head protein as the product of gene e. 19704923016
ultraviolet reactivation in bacteriophage lambda. 19704923498
properties of recombination-deficient mutants of bacteriophage lambda. 19704923748
mutants of escherichia coli with altered surface properties which are refractory to colicin e2, sensitive to ultraviolet light and which can also show recombination deficiency, abortive growth of bacteriophage lambda and filament formation. 19704924623
gal transduction by phage lambda: on the origin and nature of lft transducing genomes. 19704924698
a bacterial mutation which affects recognition of the n gene product of bacteriophage lambda. 19704924699
control of late messenger rna synthesis during lambda phage development. 19714926028
light-induced cross-linking of dna in the presence of a furocoumarin (psoralen). studies with phage lambda, escherichia coli, and mouse leukemia cells. 19704927248
polar mutations in the left arm of bacteriophage lambda i434.by studying complementation between frameshift and nonsense mutants located in the structural genes for the head of bacteriophage lambdai434, we found mutations in gene b which are polar on genes c and d and one mutation in gene e which is polar on gene f.19714927522
the role of exonuclease and beta protein of phage lambda in genetic recombination. ii. substrate specificity and the mode of action of lambda exonuclease. 19714928646
protection of irradiated lambda phage by methylated proflavine. 19714930084
nucleotide sequence analysis of dna. ii. complete nucleotide sequence of the cohesive ends of bacteriophage lambda dna. 19714931680
repair of alkylation-induced damage in escherichia coli and its bacteriophage lambda. 19714932246
[the irreparability of damage caused by 1m hydroxylamine in lambda phage when submitted to passage in e. coli hcr+ and hcr- cells]. 19704932341
temperature sensitivity of maltose utilization and lambda resistance in escherichia coli b.escherichia coli b strains that have acquired the malb region from e. coli k-12 are able to utilize maltose and to adsorb phage lambda when grown at 30 c, but when grown at 40 c they do not absorb phage lambda and are devoid of amylomaltase activity. these mal(ts) lam(ts) cells can be mutated or transduced to become able to grow on maltose at 40 c, but they still have no detectable amylomaltase activity nor functional lambda receptors at that temperature. this mal(40) phenotype is governed by a ...19714934064
dual control of arabinose genes on transducing phage lambda-dara. 19714934313
role of exonuclease and beta protein of phage lambda in genetic recombination. v. recombination of lambda dna in vitro.the sequential action of lambda exonuclease and polynucleotide ligase upon redundant joint molecules is sufficient to produce intact polynucleotide chains and heat-stable, biologically active molecules of lambda dna, whereas the action of ligase alone is insufficient. these results (a) confirm the previously described mechanism of single-strand assimilation, including a subsidiary mechanism by which the further action of lambda exonuclease is arrested when a redundant strand is completely assimi ...19714934524
ultraviolet- and x-ray-induced responses of a deoxyribonucleic acid polymerase-deficient mutant of escherichia coli.escherichia coli k-12, polal(-) is a mutant strain whose extracts are deficient in kornberg deoxyribonucleic acid (dna) polymerase activity. we have compared the mutant and parental strains on the basis of a number of responses to ultraviolet (uv) and x-irradiation. for both types of radiation, the mutant is more sensitive by approximately the same factor as measured by reduction in colony formation, depression of dna synthesis, and enhancement of dna degradation. the rate of repair of x-ray-ind ...19714935330
nucleotide sequence of a ribonucleic acid transcribed in vitro from lambda phage deoxyribonucleic acid. 19714936723
a phage lambda endonuclease controlled by genes o and p. 19714937245
purification and properties of 3-deoxy-d-arabinoheptulosonic acid-7-phosphate synthetase (phe) from a lambda arog+ transductant of escherichia coli.by incorporating arog, the structural gene for 3-deoxy-d-arabinoheptulosonic acid-7-phosphate (dahp) synthetase (phe), into the genome of a heat-inducible susr60 mutant of phage lambda, it has been possible to increase the intracellular levels of dahp synthetase (phe) in a lysogenized strain of escherichia coli some 15-fold over levels found in the wild-type strain. by using this strain, the enzyme has been purified approximately 2,000-fold compared with wild type, and various kinetic parameters ...19714937786
inactivation of escherichia coli, f' episomes at transfer, and bacteriophage lambda by psoralen plus 360-nm light: significance of deoxyribonucleic acid cross-links.we have investigated some biological consequences of light-induced psoralen-deoxyribonucleic acid (dna) adducts and find that for several escherichia coli functions (killing of strain ab2480 reca13 uvra6, inactivation of phage lambda plaque-forming ability in wild type and uvra6 hosts, loss of ability to transmit intact flac(+) episomes), a light exposure sufficient for production of a single cross-link per dna molecule correlates well with the biological consequence. although one cross-link per ...19714937788
[regulation of the transcription of bacteriophage lambda dna infecting a membranous system obtained from e. coli spheroplasts]. 19704938068
physiology of bacteriophage lambda in the restrictive host. 19684938540
mutants of bacteriophage lambda defective in vegetative genetic recombination. 19684938547
[induction of lambda phage and transduction in bacterial forms with changed synthesis of the cell wall]. 19714938667
specialized transduction of the salmonella hut operons by coliphage lambda: deletion analysis of the hut operons employing lambda-phut. 19714939450
[deletion and substitution of restriction sites in a hybrid phage lambda 80]. 19714939843
control of leftward transcription in the immunity region of escherichia coli phage lambda. 19714940113
lysis defective mutants of bacteriophage lambda: genetics and physiology of s cistron mutants. 19714940968
replication of bacteriophage dna. i. replication of dna of lambda phage defective in early functions. 19684941475
lysogenization by bacteriophage lambda and the regulation of lambda repressor synthesis. 19714942211
sensitivity of intracellular bacteriophage lambda to colicin ca42-e2.treatment of escherichia coli k-12 infected by lambda cits857 with colicin ca42-e2 resulted in partial inhibition of the infectious process. uninfected bacteria were killed by colicin with a probability of about five times that with which similarly treated lambda-infected bacteria lose plaque-forming ability. the lambda deoxyribonucleic acid (dna), when present in a bacterial cell either as the replicating dna of infectious phage or as the nonreplicating dna of superinfecting phage, was degraded ...19714943074
bacteriophage p2: interaction with phage lambda and with recombination-deficient bacteria. 19714943192
bacterial mutants in which the gene n function of bacteriophage lambda is blocked have an altered rna polymerase.bacterial mutants have been isolated, called gron, that block phage development by interference with the action of the product of the phage n gene. lambdatrp phages, which depend on the n product for the synthesis of tryptophan enzymes, do not make these enzymes in gron bacteria. two type of phage mutants have been isolated that can overcome the gron block. one type makes an altered n product, the other contains an n-bypass mutation. the gron mutation is closely linked to the rifamycin-resistanc ...19714943550
establishment and maintenance of repression by bacteriophage lambda: the role of the ci, cii, and c3 proteins.to define the events necessary for the establishment and maintenance of repression in a lambda-infected cell, we have studied the requirements for efficient synthesis of the ci protein ("lambda-repressor"). three classes of lambda mutants defective in the establishment of repression are also defective in the appearance of ci protein activity at the normal time. two of these mutational classes (cii(-) and ciii(-)) probably result from inactivation of lambda-specified proteins, but the third class ...19714943791
the formation of homoimmune double lysogens of phage lambda and the segregation of single lysogens from them. 19714944853
[study of the lambda-exonuclease activity of escherichia coli during induction of the vegetative phage and infection with temperate phage lambda]. 19714945393
a minor q-independent pathway for the expression of the late genes in bacteriophage lambda. 19714946855
initiation of infection by deoxyribonucleic acid from . . . bacteriophage lambda.kinetic studies conducted on the early stages of infection of escherichia coli k-12 by deoxyribonucleic acid (dna) isolated from bacteriophage lambda indicate a rapid adsorption of the phage dna to receptor sites at the bacterial surface prior to deoxyribonuclease-insensitive incorporation. a direct relationship found between the number of dna molecules adsorbed per bacterium and the multiplicity of helper phage infection indicates a requirement for helper function during the attachment process. ...19674960182
the role of the n gene of phage lambda in the synthesis of two phage-specific proteins. 19684973489
nonessential functions of bacteriophage lambda. 19694974326
isolation of a dna ligase from phage lambda c-1-infected escherichia coli. 19704985537
isolation of a dna-nicking enzyme from phage lambda-ci-infected escherichia coli. 19704992301
the role of exonuclease and beta protein of bacteriophage lambda in genetic recombination. i. effects of red mutants on protein structure. 19704992641
segmental distribution of nucleotides in the dna of bacteriophage lambda. 19684999721
gene expression by constitutive mutants of coliphage lambda. 19725015426
isolation and structure of phage lambda head-mutant dna. 19725022188
head assembly steps controlled by genes f and w in bacteriophage lambda. 19725022189
tandem genetic duplications in a derivative of phage lambda. ii. evidence for structure and location of endpoints. 19725023665
relationship between the n function of bacteriophage lambda and host rna polymerase. 19725040359
chemical synthesis of the "sticky end" of lambda phage dna r-strand. 19725043189
repression by the ci protein of phage lambda: in vitro inhibition of rna synthesis. 19725045305
repression by the ci protein of phage lambda: interaction with rna polymerase. 19725045306
lambda phage mutants insensitive to temperature-sensitive repressor. 3. effects of virl, virr or virc mutation on the gene expression. 19725046962
isolation and characterization of deletions in bacteriophage lambda residing as prophage in e. coli k 12. 19725057547
dna-replication of spi - mutants of bacteriophage lambda in recombination-deficient bacteria. 19725057549
the net hydration of phage lambda. 19725078393
new banding species, with densities of phage-ghost clusters, produced from lambda phage particles on storage. 19725078394
isolation and properties of rex - mutants of bacteriophage lambda.twenty-five rex(-) mutants of phage lambda have been isolated. three of the mutants, including one amber mutant, map at three distinct sites within the rex region of the lambda genetic map. the existence of the amber mutant provides further evidence that rex and ci are distinct genes, since it seems to be identical to wild-type lambda in its ability to establish or maintain lysogeny.19725084465
regulation of leftward transcription in the j-b2-att region of coliphage lambda. 19715087422
light scattering and hydrodynamic properties of linear and circular bacteriophage lambda dna. 19715126521
the arrangement of dna in lambda phage heads. i. biological consequences of micrococcal nuclease attack on a portion of the chromosome exposed in tailless heads. 19715136580
the arrangement of dna in lambda phage heads. ii. lambda dna after exposure to micrococcal nuclease at the site of head-tail joining. 19715136581
regulation of gene expression in bacteriophage lambda. 19715138255
genetic localization of two polycistronic messenger rnas from bacteriophage lambda as deduced from their base compositions and annealing properties. 19715144630
biologically active dna of bacteriophage lambda. 19665223584
function of the n cistron of bacteriophage lambda. 19665225510
regional and temporal control of genetic transcription in phage lambda. 19665225516
assembly of phage lambda in vitro. 19665227665
theory of thermal transitions in cohered dna from phage lambda. 19665230176
asymmetric distribution of the transcribing regions on the complementary strands of coliphage lambda dna. 19675231395
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