Publications

antigenic reactivities of synthetic polymers. (i) hemagglutination of polymers to red blood cells of various species and hemagglutination inhibition of guinea pig antisera.		1977	271196
differences in fluoride levels in the blood between sheep, rabbit and rat.		1977	271484
antibody formation to dog pulp tissue altered by formocresol uithin the root canal.	after pulpal extirpation of twenty teeth in each of five dogs, these animals were primarily immunized intramuscularly by combining formocresol with the dog's own pulp (three dogs), saline solution with pulp (one dog) and injecting sheep erythrocytes (one dog). a sixth dog was used as a control for the arthus skin test. secondary immunizations were accomplished via the root canal every 7 days over a 28-day period. arthus skin-test reactions demonstrated less of a response to the formocresol alone ...	1978	272610
regulation by membrane sialic acid of beta1h-dependent decay-dissociation of amplification c3 convertase of the alternative complement pathway.	sheep erythrocytes in their native state did not activate the alternative complement pathway, as measured by lysis in dilutions of normal human serum containing [ethylenebis(oxyethylenenitrilo)] tetraacetic acid but acquired this capacity after membrane sialic acid residues had been removed (by sialidase) or modified (by naio(4)). activation of the alternative pathway by sheep erythrocytes required removal or modification of at least 40% of the membrane sialic acid to reach threshold, and it inc ...	1978	273923
traumatically induced defects of enamel in permanent teeth in sheep.		1977	274475
naturally acquired coccidia infection in lambs in otago.		1977	275679
scrapie: a point of view.		1977	275684
the efficacy of oxfendazole against natural infections of nematodes & cestodes in sheep.		1977	275686
metabolic changes in some helminths from sheep treated with mebendazole.		1977	275698
an evaluation of five commonly used anticoagulants, in relation to the accuracy of haematological tests for bovine, ovine, equine and canine blood.		1977	275700
the protective effect of zinc sulphate in experimental sporidesmin poisoning of sheep.		1977	275707
environmental reservoirs of psychrotrophic meat spoilage fungi.		1977	275714
subclinical pneumonia in lambs.		1977	275716
deaths in sheep after overdosage with thiabendazole.		1977	275718
genital infection of ram hoggets associated with a gram-negative pleomorphic organism.		1977	275719
the influence of micro-organisms on the severity of lesions in chronic ovine pneumonia.		1977	275720
clinical and biochemical changes in sheep inoculated with leptospira interrogans serotype pomona.		1977	275721
acute selenium poisoning: case report.	a case of self-poisoning with sodium selenate sheep drench, along with blood and urine levels of selenium, is reported. treatment included gastric lavage, diuresis, vitamin c, and dimercaprol, and the patient recovered without sequelae.	1978	276714
toxicity of zinc in ruminants in relation to facial eczema.		1977	276728
unwarranted publications.		1977	276739
scrapie- the risks in perspective.		1977	276740
scrapie-a point of view.		1977	276749
scrapie: a point of view.		1977	276750
the effect of mebendazole and praziquantel on the cysts of echinococcus granulosus, taenia hydatigena and t. ovis in sheep.		1978	276754
nodular lesions in the absence of oesophagostomum columbianum.		1978	276759
cft inaccurate for epididymitis.		1978	276760
short returns in ewes synchronised with prostaglandins.		1978	276761
factors associated with wounds and bruises in lambs.		1978	276762
bacteriological evaluation of bruised tissue in lamb carcasses.		1978	276763
cft inaccurate for epididymitis.		1978	276767
observations on the epidemiology of malignant catarrhal fever.		1978	276769
comparison of a new sheep dipping technique with saturation-type methods.		1978	276770
complement c3 convertase: cell surface restriction of beta1h control and generation of restriction on neuraminidase-treated cells.	the alternative or properdin pathway of complement is primarily controlled by the endopeptidase c3b inactivator (c3bina) and the nonproteolytic glycoprotein beta1h. the molecular mechanisms of control were investigated by performing binding studies of radiolabeled complement proteins to c3b bearing sheep erythrocytes (e(s)c3b). c3b was found to have distinct binding sites for beta1h, c3bina, factor b, and properdin. beta1h binding increased c3bina binding 30-fold, while factor b binding prevente ...	1978	276881
proliferative state of blast cell progenitors in acute myeloblastic leukemia (aml).	peripheral blood from patients with acute myeloblastic leukemia (aml) contains cells capable of giving rise to colonies in culture when stimulated by media conditioned by leukocytes (lcm) in the presence of phytohemagglutinin (pha). two types of colonies are recognized with high frequency: the first grows in the presence of low concentrations of pha lcm, have a blast-like morphology, and are numerically correlated with morphologically identified blast cells. the second requires either high pha l ...	1978	277270
the effects of human saliva on the hemolytic activity of complement.	human saliva was tested for the presence of factors that affect the complement system. parotid saliva and salivary fractions were incubated at 37 c with human serum as a source of complement. samples removed from the mixtures within the first 15 minutes had higher levels of whole hemolytic complement activity than did appropriate controls. the final ionic strength of the saliva-serum mixtures was critical to the hemolytic activity of complement. after 60 minutes all serum-saliva mixtures had low ...	1978	277485
atresia of the small intestine in lambs and calves.		1978	277828
two cases of intestinal adenocarcinoma in aged ewes.		1978	277829
cft inaccurate for epididymitis.		1978	277832
cardiovascular effects of epidural analgesia. i. thoracic epidural analgesia. an experimental study in sheep of the effects on central circulation, regional perfusion and myocardial performance during normoxia, hypoxia and isoproterenol administration.	some circulatory effects of thoracic epidural analgesia (tea) were investigated in splenectomized, open-chest sheep during normoxia, hypoxia and isoproterenol administration. during normoxia, tea caused comparatively marked reductions in systemic arterial blood pressure, total peripheral resistance and cardiac output. a fall in heart rate was not compensated for by any rise in stroke volume. myocardial contractility (lv dd/dt/ip) was not affected by tea. the proportion of cardiac output diverted ...	1978	277892
cardiovascular effects of epidural analgesia. ii. haemodynamic alerations secondary to lumbar epidural analgesia and their modification by plasma expansion and adrenaline administration. an experimental study in the sheep.		1978	277893
in vitro biosynthesis and chemical characterization of beta-lipotropin, gamma-lipotropin, and beta-endorphin in rat pars intermedia.	three 3-hr incubations of pars intermedia cells from 40 rat pituitaries with [35s]methionine, [3h]lysine, and [3h]leucine sufficed for the identification and chemical characterization of biosynthesized beta-lipotropin, gamma-lipotropin, and beta-endorphin. from the molecular weight, migration on polyacrylamide gels, and sequence met5, lys9, leu14,17, rat beta-endorphin was shown to be identical to its sheep homologue and no trace of leu5 beta-endorphin could be detected. rat beta-lipotropin diff ...	1978	277917
enzootic pneumonia-pleurisy complex in sheep and lambs.		1978	278919
scrapie scruples.		1978	278924
membrane sialic acid on target particles modulates their phagocytosis by a trypsin-sensitive mechanism on human monocytes.	monolayers of human peripheral blood monocytes in the absence of exogenous proteins ingest a variety of natural particulate activators of the human alternative complement pathway. sheep erythrocytes, which do not ordinarily activate the human alternative complement pathway or initiate a direct monocyte phagocytic response, can be modified to exhibit both functions by the deletion or alteration of membrane sialic acid residues. enzymatic removal of the sialic acid residues with sialidase or their ...	1978	278997
the endorphins, novel peptides of brain and hypophysial origin, with opiate-like activity: biochemical and biologic studies.		1977	279259
a betalph precursor model: recent developments concerning morphine-like substances.	in summary, the pituitary glands from at least four species contain betalph and and beta endorphins. we have shown that in slices of whole pituitaries betalph is actively biosynthesized and transformed into gammalph, thus releasing the cooh-terminus portion 61--91, which is now known as beta-endorphin. newly radioactive biosynthesized beta-endorphin has been clearly and definitely identified. the release of betamsh and possibly of beta-endorphin could well be under the control of crf. the interm ...	1977	279264
acceleration of scrapie in mice by target-organ treatment with interferon inducers.	interferon inducers were used in the target-organ treatment of scrapie in mice. intracerebral treatments began 24 hr prior to intracerebral inoculation of 10(4.8) ld50 of the chandler strain of scrapie agent. the treatments included 30 and 0.3 microgram poly(i:c) given weekly 9 times, 45 microgram statolon given biweekly 7 times, or 1.5 ha units of sendai virus given biweekly 6 times. all treatments except the lower dose of poly(i:c) accelerated death in scrapie-affected mice. compared to saline ...	1977	280156
the anthelmintic activity of some benzimidazole derivatives against fasciola hepatica.		1978	281659
observations on the pathology of eperythrozoon ovis infection in sheep.		1978	281661
echinococcus granulosus, taenia hydatigena, t. ovis: evaluation of cyst fluids as antigen for serodiagnosis of larval cestodes in sheep.		1978	281662
molecular nature of the complement lesion.	the principle molecular event leading to membrane perturbation by complement is the assembly of the terminal five serum complement components (c5b-c9) into a macromolecular c5b-9 complex on the target membrane [müller-eberhard, h.-j. (1975) ann. rev. biochem. 44, 697--723]. the present communication reports on the ability of purified c5b-9 complexes isolated from target membranes to become reincorporated into artificial lipid vesicles. the data indicate that the complex is a vertically oriented, ...	1978	281714
hemoglobin switching in sheep: only the gamma gene is in the active conformation in fetal liver but all the beta and gamma genes are in the active conformation in bone marrow.	differential expression of the closely linked gamma, beta(a) (or beta(b)), and beta(c) globin genes in sheep results in the production of fetal hemoglobin (hb f, alpha(2)gamma(2)) during gestation and the adult hemoglobins (hb a, alpha(2)beta(2) (a), and hb b, alpha(2)beta(2) (b)) after birth. erythropoietic stress in certain animals leads to production of hb c (alpha(2)beta(2) (c)). the molecular mechanism of differential expression of these genes in nuclei of fetal and adult erythroid cells ha ...	1978	282609
lung carcinoma of sheep (jaagsiekte): tissue-bound precipitating antibodies.	firmly bound igg was examined and its activity was tested in spontaneous lung carcinoma of sheep (jaagsiekte). high levels of igg were extracted by acid-glycine buffer (gb) at ph 2.8 from both the tumor tissue and normal lung, which were exhaustively prewashed by phosphate-buffered saline (pbs) at ph 7.4. the first acid-gb eluates of the normal or tumor tissue acted in the immunodiffusion test as precipitating antibodies against antigens of the first pbs eluate of the tumor tissue. in addition, ...	1979	283268
in vivo antitumor activity of various forms of delayed-type hypersensitivity in mice.	relationships among various forms of delayed-type hypersensitivity (dth) and nonspecific resistance to lewis lung tumor were studied in syngeneic and semisyngeneic mice. only the tuberculin type of dth obviated a virulent inoculum of 10(6) tumor cells. the jones-mote type of dth, even modified by cyclophosphamide pretreatment, produced a significant local inflammatory reaction which was unable to destroy tumor cells. the antitumor effect of the tuberculin type was observed in bcg-or in corynbact ...	1979	283275
the scrotal mange mite, chorioptes bovis (hering, 1845) on sheep: seasonality, pathogenicity and intra-flock transfer.		1978	284239
a condition resembling ovine white liver disease in lambs on irrigated pasture in south canterbury.		1978	284244
analysis of 5-methoxytryptamine in brain by gas chromatography mass spectrometry.	a quantitative gas chromatographic mass spectrometric method using a deuterated analogue as internal standard were developed for the analysis of 5-methoxytryptamine in brain. the internal standard was synthesized in two steps and possessed high isotopic purity. the analytical procedure involves the addition of the internal standard to the homogenizing medium containing the tissue, followed by homogenization, extraction with chloroform and derivatization with pentafluoropropionic anhydride. the i ...	1979	284809
comparative effects of cyclophosphamide, isophosphamide, 4-methylcyclophosphamide, and phosphoramide mustard on murine hematopoietic and immunocompetent cells.	the effects of equimolal doses of cyclophosphamide (cy), isophosphamide (ip), 4-methylcyclophosphamide (4-mcy), and phosphoramide mustard (pm) on murine hematopoietic spleen colonies and adoptively transferred antibody-forming cells in vivo were compared. equimolal doses of the drugs produced significantly different effects. all the drugs exerted an increasing effect against the ability of adoptively transferred immunocompetent cells to produce a significant anti-sheep red blood cell titer as th ...	1979	285298
interrelationship of immunologic characteristics, proliferation pattern, and prednisone sensitivity in acute lymphoblastic leukemia of childhood.	in children with acute lymphoblastic leukemia (all) the effect of prednisone therapy on the cell-cycle phase distribution of leukemic bone marrow cells was determined with pulse cytophotometry at the time of diagnosis. also, the interrelationship with the presence of the sheep erythrocyte receptor as a marker for t cells was investigated. in 17 or 21 patients prednisone treatment caused a decrease in the percentage of cells in the s+g2+m phases. in 11 of 12 adult patients with all the same resul ...	1979	285734
fc-receptor variants of a mouse macrophage cell line.	variants of the j774 mouse macrophage cell line that lack immunologically important membrane receptors were isolated. after mutagenesis, variants were selected in a metrizamide gradient that separated cells heavily rosetted with sheep erythrocytes (e) coated with rabbit anti-e igg (eigg) from poorly rosetted cells. stable variants that exhibited altered binding were found with a frequency of <10(-7), and five clones were studied in detail. the variants failed to bind e opsonized with a monoclona ...	1979	286323
detection of specific hybridoma clones by replica immunoadsorption of their secreted antibodies.	a sensitive and rapid method for the detection of monoclonal antibodies secreted by hybridomas is described. mouse myeloma cells are fused with spleen cells from immunized mice and directly cloned in soft agarose containing selective medium; hybrid clones can be seen after a week. nitro-cellulose filters that have been coated with a specific protein antigen, with antigen-coupled erythrocyte ghosts, or with other cells used as antigens are then placed on the agarose surface. after incubation to a ...	1979	286325
research progress on foot rot in sheep.		1977	286357
trichobezoar in an infant: case report.	a case of a trichobezoar in an infant is reported. this was caused by nursing the child on a sheep skin rug.	1979	286918
observations on brucella ovis cft results.		1978	286955
sheep medicine, quo vadis?		1979	286957
choleragen (cholera toxin): a bacterial lectin.	choleragen (cholera toxin) agglutinated erythrocytes and liposomes containing the toxin receptor, galactosyl-n-acetylgalactosaminyl-(n-acetylneuraminyl)-galactosylglucosylceramide (ganglioside gm1). cells that had been exposed to gm1 were agglutinated, but agglutination was not observed when cells had been exposed to other gangliosides (gm2, gm3, gd1a, gd1b). choleragen-dependent agglutination of liposomes was slightly less specific, because liposomes containing either gm1 or gd1b, but neither g ...	1979	287006
problems of sheep and goats.		1978	287103
isolation of mycoplasma and ureaplasma from sheep and goats in west texas (1970-78).		1978	287105
isolation of mycoplasma from pneumonic lungs of sheep and goats in mexico.		1978	287108
a study on the causes of abortion/stillbirth/perinatal lamb loss in oregon.		1978	287109
toxic effects of di-n-octyltin dichloride on the thymus in mice.	the effects of di-n-octyltin dichloride (dotc) on the thymus in mice were studied in dependence on the route of administration. single administrations of 30, 60 and 120 mg/kg of dotc i.m. induced a dose-related decrease of the thymus weight and of the number of nucleated cells in the thymus of male mice. 4 days after intravenous injection of 8 mg/kg of dotc the thymus weight and the number of thymocytes were reduced to 50 percent of the control. in oral route of administration higher doses of do ...	1979	288338
hand-mirror cell leukemia associated with mental retardation: immunologic, chromosome, and morphological studies.	cycochemical, morphological, immunologic, and cytogenetic studies were carried out on hand-mirror cells (hmc) from a mentally retarded patient with a constitutional chromosome abnormality, 46,xx,r(21), and acute lymphoblastic leukemia. scanning electron and differential interference contrast microscopy showed microspikes on the uropodia, but little evidence of cellular motility, despite formation and disappearance of individual uropodia in cell suspensions. the cells rosetted with sheep erythroc ...	1979	288487
on the occurrence of 5-methoxytryptamine in brain.	a quantitative gas chromatography-mass spectrometry method has been used to determine 5-methoxytryptamine (5-mt) in the cns and pineal gland of various species. the mean +/- s.d. levels of 5-mt in sheep, pig and cow pineal glands was 545 +/- 180, 228 +/- 119 and 117 +/- 48 pmol/g, respectively. the postmortem levels of 5-mt in the pig pineal gland was stable for 2 h after death but decreased by more than 90% 24 h after death. in the cns, 5-mt was found only in the sheep hypothalamus (28 +/- 4 pm ...	1979	290404
fc receptors on myeloid leukaemic cells: comparison between assays of rosette-forming cells.	a comparison has been made between assays of fc receptor bearing cells among blood leucocytes from normal individuals and from patients with myeloid leukaemia, using human anti-d coated erythrocytes (hea) and sheep erythrocytes sensitised with a rabbit anti-sheep erythrocyte antibody (sea). differences were found between the assays in both groups, demonstrating the heterogeneity of fc receptors with respect to affinity for marker, and for fc bearing leucocytes. monocytoid cells reacted more read ...	1979	290690
transport of tryptophan and other amino acids by mammalian erythrocytes.	mammalian erythrocytes are known to have 4 distinct amino acid transport systems. the c system is found in sheep erythrocytes and is specific for neutral amino acids of intermediate size. human cells lack the c system and have two alternative neutral amino acid transport mechanisms: the l system which is selective for large hydrophobic amino acids and a na-dependent alanine-cysteine system. the l system is absent from ruminant and cat erythrocytes. human rabbit and cat cells, but not sheep eryth ...	1979	290751
blood selenium values in an adult auckland population group.	new zealand top soils are low in selenium with some regional variation. grain and cereal products are the main source of dietary selenium intake but in new zealand their content is low due to widespread top soil deficiency. whole blood levels reported from oago, 68 +/- 13ng/ml, are a half to one-third of those in north america and also lower than in auckland residents, 79 +/- 15.7ng/ml. the variation between new zealanders is due to regional differences in top soil levels and grass content affec ...	1979	290885
role of carbohydrate in biological function of the adhesive glycoprotein fibronectin.	we have investigated the role of the carbohydrate moiety in the biological activity of fibronectin in vitro by using tunicamycin to inhibit the glycosylation of this glycoprotein. tunicamycin is a glucosamine-containing antibiotic that specifically inhibits glycosylation of protein asparaginyl residues mediated by dolichol pyrophosphate. fibronectin synthesized in the presence of 0.5 microgram of tunicamycin per ml was not glycosylated, as determined by amino sugar analysis, lack of incorporatio ...	1979	291008
aspects on the choice of experimental animals when reproducing missile trauma.		1979	291246
37 degrees ce rosettes in various malignant and non-malignant disorders.	t lymphocytes, forming sheep erythrocyte rosettes at 37 degrees c, have been described in thymus glands, mitogen and allogeneic cell stimulated lymphocyte cultures, and acute t cell lymphoblastic leukaemia. this paper describes the finding of such lymphocytes in lymph nodes of a variety of disorders including hodgkin's disease, lennert's lymphoma, malignant lymphoma of large transformed t lymphocytes, immunoblastic lymphadenopathy, metastatic carcinoma, and other disorders. a large number of ton ...	1979	291439
a syndrome of dental abnormalities of sheep: i. clinical aspects on a commercial sheep farm in the wairarapa.		1979	291821
observations of subcutaneous haemorrhagic speckling in lambs.		1979	291823
intestinal polyps in a lamb.		1979	291824
electrophoretically pure mouse interferon exerts multiple biologic effects.	electrophoretically pure mouse interferon was examined for a number of biologic effects previously ascribed to crude or partially purified interferon preparations. these effects include: inhibition of the growth of a transplantable tumor in mice; inhibition of cell multiplication of mouse tumor cells in vitro; enhancement of the expression of histocompatibility antigens on mouse tumor cells in vitro; inhibition of antibody formation in vitro; inhibition of sensitization to sheep erythrocytes and ...	1979	291948
an in vitro study of the replication of mycoplasma ovipneumoniae.		1979	292899
studies on dystocia in sheep. i. a technique for radiographic pelvimetry in the ewe.		1979	292901
studies on dystocia in sheep. ii: pelvic measurements of ewes with histories of dystocia and eutocia.		1979	292902
intraperitoneal vaccination of rams against brucella epididymitis.		1979	292907
intraperitoneal vaccination of rams.		1979	292908
urinary methylmalonic acid as an indicator of the vitamin b12 status of grazing sheep.		1979	292914
the prevalence of salmonella infection in sheep at slaughter.		1979	292915
inherited goitre in sheep.		1979	292923
petechial haemorrhages in carcass fat of slaughtered lambs.		1979	292930
protection of sheep by vaccination against artificial challenge with leptospira interrogans serovar hardjo.		1979	292933
experimental infection of sheep with leptospira interrogans: serovars hardjo and balcanica.		1979	292934
endocrinology of spermatogenesis in the hypophysectomized ram.	adult rams were hypophysectomized and treated for 20 days with testosterone (2 x 0.25 g/day), pmsg (2 x 300 i.u./day) or hcg (2 x 250 i.u./day), or for 40 days with testosterone (2 x 0.25 g/day). all treatments maintained a normal concentration of testosterone within the seminiferous tubules. quantitative histological analysis showed that (1) the differentiation from a0 to a1 spermatogonia was maintained by pmsg or hcg but not completely by testosterone; (2) the transition from intermediate sper ...	1979	293407
the effects of long-term administration of either a crude inhibin preparation or an antiserum to fsh on serum hormone levels, testicular function and fertility of adult male rats.	adult male rats were given either daily injections of ram rete testis fluid for periods of up to 70 days or injections of an antiserum against fsh every 3 days for 90 days. compared with the control groups, the rats injected with ram rete testis fluid had lowered serum fsh levels, but only at treatment periods of 30 days and less. the levels of lh and testosterone in serum, testicular fluid secretion, sperm counts, testis weights and fertility were not affected by rete testis fluid treatment. th ...	1979	293409
characterization of a gonadal factor involved in the control of fsh secretion.	this communication presents evidence for the existence in the ovine testis of proteinaceous factors which suppress lh as well as fsh. isolation of these factors has been achieved by using three different procedures: cytosol preparation, metaphosphoric acid extraction and ultrafiltration. chromatography of cytosol or metaphosphoric acid extract on sephadex g-75 resulted in separation into three protein fractions designated as g-75-i, ii and iii in order of their elution. when administered to cast ...	1979	293412
inhibin in ram rete testis fluid.		1979	293413
acute lymphoblastic leukemia in children: immunologic, cytochemical, morphologic, and cytogenetic studies in relation to pretreatment risk factors.	thirty children with previously untreated acute lymphoblastic leukemia were studied prior to therapy to determine whether sheep erythrocyte (e)-receptor status correlated with clinical factors, cytochemical staining characteristics, fab morphologic classification, and karyotype. five patients (17%) with more than 50% e+ blasts had intense focal acid phosphatase staining and distinct clinical characteristics, including high leukocyte counts, mediastinal masses, and involvement of the central nerv ...	1979	293495
regulation of the amplification c3 convertase of human complement by an inhibitory protein isolated from human erythrocyte membrane.	an activity that is inhibitory to the properdin-stabilized amplification c3 convertase (c3b,bb,p) was solubilized from human erythrocyte (e(hu)) membranes by nonidet p-40 and purified to homogeneity. the inhibitory membrane glycoprotein had an apparent m(r) of 1-1.2x10(6) on gel filtration in the presence of nonidet p-40. on sodium dodecyl sulfate/polyacrylamide gel electrophoresis it presented a single stained band with an apparent m(r) of 205,000, with or without prior reduction of disulfides. ...	1979	293688