Publications

significance of antibody studies in leprosy and experimental models of the disease.		1982	6754640
cultivation, the neglected priority.		1982	6754641
[study of experimental leprosy in nude-mice inoculated with m. leprae--light and electron microscopic findings].		1981	6754678
radiolabelled m. leprae resident in human macrophage cultures as an in vitro indicator of effective immunity in human leprosy.	twelve strains of human derived, freshly extracted m. leprae maintained within human macrophages showed a 2.1-13.2-fold increase in the incorporation of 3h-thymidine compared to parallel cultures containing heat-killed bacilli of the same strain. the addition of antigen stimulated lymphokines from five paucibacillary, tuberculoid leprosy patients resulted in the inhibition of the uptake of the radiolabel by 49-87%. minimal, or no, inhibition was noted in the presence of similar culture supernata ...	1982	6756718
iga, igm and igg anti-m. leprae antibodies in babies of leprosy mothers during the first 2 years of life.	iga, igm and igg anti-m. leprae antibody activity was estimated by solid phase radioimmunoassay in repeated serum samples from cord sera to sera taken 2 years after birth from 29 babies of mothers with lepromatous leprosy (group 1) and 16 babies of mothers with tuberculoid leprosy and non-leprosy control mothers (group 2). iga anti-m. leprae antibody activity could be detected in 30% and igm anti-m. leprae antibody activity in 50% of cord sera from group 1, but not in any of the cord sera from g ...	1982	6756719
drug resistance and multi-drug therapy in leprosy.		1982	6757576
solid, fragmented and granular index as one of the parameters in drug trials.	a bacteriological study of the skin smears of 108 bacteriologically positive cases of leprosy, 30 of them untreated, has been undertaken. in each case solid, fragmented and granular (sfg) index, bacteriological index (bi) and morphological index (mi) of skin smears from 4 sites were calculated. the results show that sfg index together with bi can be used as one of the parameters in drug trials. the importance of sfg index in research and as a routine laboratory procedure in leprosy control units ...	1982	6757578
effect of freezing mycobacterium leprae in tissues.	the effects of freezing tissues from m. leprae-infected armadillos as well as biopsy specimens from leprosy patients have been studied. no loss of viability of m. leprae was observed using mouse foot pad technique. similarly, using bioluminescent determinations of bacterial atp, it was shown that these bacilli retain all their metabolic activity during such freezing and thawing process. the practical implications of these findings have been discussed.	1982	6757579
[vaccination against leprosy].		1982	6758711
structure of the wall polysaccharide isolated from a group of corynebacteria.		1982	6759115
the use of subcellular components of bcg for studying host-mycobacterium interaction in relation to leprosy.		1982	6760793
use of a unit gravity sedimentation chamber for the purification of mycobacterium leprae.	the present paper summarizes results concerning a mild isolation method of mycobacterium lepraemurium and m. bovis-bcg from host tissues, and describes the application of such a method in purifying m. leprae (m1) from either infected armadillo tissues or human skin biopsies. this isolation method consists of homogenization, two-phase partition in dextranpolyethylene glycol and finally sedimentation in sucrose gradient using a unit gravity chamber. such a purified m1 preparation appears to be dev ...	1982	6762126
serological approaches for the characterization of catalase in tissue-derived mycobacteria.	cell-free extracts of mycobacterium lepraemurium from mouse liver and m. leprae from armadillo liver were analysed for the presence of any mycobacterial catalase by using the specific inhibitor 3-amino-1,2,4-triazole and seroprecipitation titrations. these studies clearly demonstrated the presence of a "t" type of mycobacterial catalase in m. lepraemurium and placed it, in terms of immunological distance, in a position between m. tuberculosis and m. avium. the results did not reveal any detectab ...	1982	6762127
chemotherapy of the mycobacterial diseases--leprosy and tuberculosis.		1982	6762341
attempts to establish host cells for mycobactrium leprae in vitro by hibridizing mouse macrophages and hela cells.		1982	6762775
adherence of mycobacterium leprae to macrophage as an indicator of pathogen induced membrane changes.		1982	6762986
immunotherapy with a mixture of mycobacterium leprae and bcg in different forms of leprosy and in mitsuda-negative contacts.	a total of 529 weak or non-reactors to m. leprae, including mitsuda-negative contacts and patients with leprosy, were vaccinated once or repeatedly, as necessary, with a mixture of 6 x 10(8) purified, heat-killed m. leprae and 0.01 mg to 0.2 mg of viable bcg. clinical, histopathological and immunological criteria were used to evaluate the response of these individuals. clinical changes, including sharper definition of borders and progressive flattening and regression of lesions, were observed in ...	1982	6763002
in vitro lymphocyte stimulation in patients with lepromatous and borderline tuberculoid leprosy. the effect of dapsone treatment on the response to mycobacterium leprae antigens, tuberculin purified protein derivative and non-mycobacterial stimulants.	lymphocytes from peripheral blood were isolated from leprosy patients and healthy contacts (hc) of leprosy patients and stimulated in vitro with: mycobacterium leprae and a m. leprae cell wall antigen, mlw 1; tuberculin purified protein derivative (ppd); antigens prepared from candida albicans, entamoeba histolytica, leishmania aethiopica, and parotitis virus; the non-specific mitogens phytohemagglutinin (pha) and concanavalin a (con-a). lymphocytes from patients with untreated lepromatous lepro ...	1982	6763003
the morphology of bacilli at different levels of the dermal infiltrate in lepromatous leprosy.	the morphological index (mi) of bacilli at three levels of the granuloma in 20 skin biopsies from untreated lepromatous patients has been recorded. the more superficial part of the granuloma and the subepidermal free zone showed a significantly higher mi, compared to the mid and lower zones. possible reasons for this non-uniform distribution of morphologically intact bacilli are discussed.	1982	6763004
failure to validate the growth of mycobacterium leprae on m-y 14b agar medium.	confirmation experiments on colony formation of m. leprae on the m-y 14b agar medium developed by murohashi and yoshida were carried out for two years independently by individual members of an organized research group, according to the method described by murohashi and yoshida. the results obtained can be summarized as follows: a) no colony production by m. leprae on m-y 14b agar medium was seen. b) no increase in the number of cells of m. leprae on m-y 14b agar medium during cultivation was see ...	1982	6763005
leprosy and tuberculosis.		1982	6763794
leprosy--a disease of the schwann cell.		1982	6763963
quantitative analysis of the sequence of nerve damage in experimental leprosy.		1982	6763964
a study of continuous bacillaemia in borderline and lepromatous type of leprosy.	the present work has established beyond doubt that bacillaemia occurs practically in all cases of borderline and lepromatous leprosy. the number of bacilli in the blood is significantly high, to the tune of 4,000 bacilli per ml. even so, it does not produce any adverse symptoms of septicaemia. special emphasis was laid in the present study for determining the continuity or otherwise of bacillaemia. some of the patients had continuous bacillaemia according to the criteria fixed in the present stu ...	1982	6763965
mouse foot-pad growth patterns of m. leprae in relation to morphological index.		1982	6763966
immune status of subsided cases of tuberculoid (tt) and borderline tuberculoid (bt) leprosy.	a comparative study of lepromin reactions (early and late), m. leprae induced lymphocyte blastogenesis, per cent t cell number in peripheral blood and immunoglobulin (igg, iga and igm) levels have been made in tt-active, tt-subsided, bt-active and bt-subsided leprosy cases. no significant difference has been noted amongst these groups in the above mentioned investigations except in subsided bt cases where 9 out of 11 cases failed to evoke any late skin reaction to dharmendra antigen. in addition ...	1982	6763967
susceptibility of the host--role of non-genetic factors.		1982	6763968
an appraisal of medical research in the treatment and control of leprosy.		1982	6763969
the microscopical pattern of growth of mycobacterium leprae-murium "douglas" in microcolonies.	a thin section technique of ogawa egg yolk culture medium inoculated with mycobacterium leprae-murium was found to reveal microscopical growth of the strain which could not be demonstrated by macroscopical examination. a peculiar structure of the growth, characterized by many lytic spots different in size, was observed indicating the possible presence of a temperate phage which may interfere with the synthesis of nucleic acids needed for the active multiplication of m. leprae-murium.	1982	6764333
dna isolated from mycobacterium leprae: genome size, base ratio, and homology with other related bacteria as determined by optical dna-dna reassociation.	dna derived from mycobacterium leprae (grown in armadillos) was isolated, purified, and analyzed spectrophotometrically. the genome size and guanine-plus-cytosine content of m. leprae were 1.3 x 10(9) and 55.8%, respectively. among selected strains of mycobacterial, nocardial and corynebacterial species, corynebacterium sp. 2628 lb, isolated from a human leprosy patient, showed the highest dna homology with m. leprae. of the dnas derived from mycobacteria, those of m. tuberculosis and m. scroful ...	1982	6764515
[comparison of the stamp specimens with histopathological tissue sections of the ear lobe].		1982	6764762
mast cell and mycobacterium leprae in experimental leprosy.	the association of mast cells and lepra bacilli was studied in the foot pad skin of immunosuppressed mice inoculated with 10(5) lepra bacilli. the mice were killed at intervals varying from 2 1/2-14 months postinoculation. m. leprae are found in large numbers in nerves, blood vessels, muscle fibres, hair follicles, sweat and sebaceous glands. mastocytosis and extensive degranulation are seen at similar sites. since these are the structures most affected in leprosy where the lepra bacilli and deg ...	1982	6764919
[acid-fast bacilli in the water of the lake of aleixo].	the presence of acid-fast bacilli in the waters of the lake of aleixo is recorded. this site is a hanseniasis colony. the physical-chemical environment of this lake is described by an annual cycle and it is intended to relate the quality of the water to the highest or to the lowest frequency of detected mycobacteria. it is suggested that the work in this lake system should be continued towards a more specific characterization of these microorganisms and the determination of their viability.	1982	6764920
case for diagnosis.		1980	6772986
production of a suppressor factor by human adherent cells treated with mycobacteria.	human peripheral blood mononuclear cell (mn) proliferation and lymphokine production induced by mitogen could be inhibited by heat killed whole mycobacteria. the inhibition was induced by a wide variety of mycobacteri but not by other gram-positive or gram-negative organisms or by latex particles. proliferation and lymphokine production by adherent cell-depleted lymphocytes was not inhibited by these organisms. adherent cells treated with mycobacteria had the ability to inhibit lymphocyte blasto ...	1980	6774019
inhibition of the incorporation of [3h]dopa in mycobacterium leprae by desoxyfructo-serotonin.		1980	6775637
an assay for antibodies in leprosy sera reacting with ribonucleoprotein (rnp), a mycobacterial ribosomal antigen, using crossed immunoelectrophoresis with intermediate gel.	the technique of crossed immunoelectrophoresis with intermediate gel has been adapted to provide a quantitative assay for antibodies to a mycobacterial ribosomal antigen termed ribonucleoprotein (rnp) antigen. this antigen is no. 1 in the m. smegmatis reference system and corresponds to antigen no. 5 of m. leprae. the assay method measures changes in the rate of migration of the reference precipitin peak caused by the addition of serum in the intermediate gel and utilizes a lepromatous serum poo ...	1980	6777312
antibodies to mycobacteria in human tuberculosis. ii. response to nine defined mycobacterial antigens with evidence for an antibody common to tuberculosis and lepromatous leprosy.	antibodies to mycobacterial antigens were found in the sera of 33 of 52 patients with active tuberculosis by microimmunodiffusion tests. the highest titered sera were examined by a technique in which sera are placed in an intermediate gel between a reference goat antiserum field and a gel containing the antigens separated by one-dimensional electrophoresis. special patterns caused by the presence of patient's serum during the two-dimensional electrophoresis showed that nine distinct antibodies c ...	1980	6780633
a possible method for improving the efficacy of dapsone.	the antileprosy drug dapsone is unable to penetrate intact mycobacterium leprae in vitro, as determined by its effect on o-diphenoloxidase in the bacilli. when combined with the peptide polylysine, the sulfone drug passes through the bacterial cell membranes, and penetrates the enzyme protein, resulting in a 100% inhibition of its activity.	1980	6781921
antigenic evaluation of mycobacterium vaccae in relation to mycobacterium leprae.	immunodiffusion analysis of mycobacterium vaccae indicated the presence of at least nine antigens. using the technique of fused rocket immunoelectrophoresis, at least 13 such antigens were detected. comparative analysis of the m. vaccae antigen-antibody system with similar systems established for other mycobacterial species showed that m. vaccae shared a significant number of antigens with both typical and atypical mycobacteria. these included the already described beta and delta antigens that a ...	1980	6782031
cultivation of m. leprae in cell-free, semi-synthetic media.	attempts to cultivate m. leprae in cell-free, semi-synthetic media of various forms with lowered oxidation-reduction potential after due consideration of the biological significance of the acid-fastness of mycobacteria, resulted in the growth of this organism to the extent of visible to the naked eye. studies on the nutritional requirements at 30 degrees c, suggesting to have quite similar enzyme system as other bacterial species, if not quantitatively, but at least qualitatively. successful cul ...	1980	6782814
[a model for growing mycobacteria from leprous tissues placed in aliphatic hydrocarbons, tetradecane, a preliminary report].	strains of mycobacteria were regularly cultured from human and armadillo lepromata in liquid media, supplemented with tetradecane and dimethylsulfoxide. these substances had to be emulsified with heavy inoculum in order to obtain positive subcultures in the tetradecane-dmso media. the use of nonpurified suspension of host-grown cells was advantageous for the primary cultivation. subcultures were grown in the inorganic salt-tetradecane-dimethyl-sulfoxide liquid media. strains did not grown on löw ...	1980	6782815
failure to detect o-diphenoloxidase in cultivable mycobacteria obtained from feral armadillos.		1980	6783793
a claim for a mycobacterium leprae specific antigen.		1981	6788723
permeability of mycobacterium leprae to dapsone: alteration by purification procedures.	permeability of mycobacterium leprae to dapsone in vitro was determined by the ability of the drug to inhibit o-diphenoloxidase of the bacilli. dapsone showed little effect on the enzyme activity of the intact organisms. when the m. leprae preparations were washed with trypsin, naoh, or acetone and ether, dds penetrated the bacillus to inhibit its o-diphenoloxidase. the method might be useful in studying the utilization of added metabolites by purified m. leprae suspensions.	1981	6789004
hydrocarbons of petroleum: ideal substance for mycobacteria.		1980	6789600
bacterial persistence in leprosy.	bacterial persistence is the capability of microorganisms to survive in the host despite adequate antimicrobial treatment. this is a general phenomenon and has been observed during infection with a number of organisms. the subject is reviewed in relation to the treatment of leprosy. the presence of persisters in the large bacterial populations that exist in patients with lepromatous leprosy is not surprising. it is unlikely that in the near future a new drug or combination of drugs will be found ...	1981	6792087
the six disease of who.		1981	6794841
an overview of carville research.		1981	6797220
in vitro cultivation of m. leprae.		1981	6797806
increase in prevalence of leprosy caused by dapsone-resistant mycobacterium leprae.		1982	6798411
dna isolated from mycobacterium leprae: genome size, base ratio, and homology with other related bacteria as determined by optical dna-dna reassociation.	dna derived from mycobacterium leprae (grown in armadillos) was isolated, purified, and analyzed spectrophotometrically. the genome size and the guanine-plus-cytosine content of m. leprae were 1.3 x 10(9) and 55.8%, respectively. among selected strains of mycobacterial, nocardial, and corynebacterial species, corynebacterium sp. 2628 lb, isolated from a human leprosy patient, showed the highest dna homology with m. leprae. of the dnas derived from mycobacteria, those of m. tuberculosis and m. sc ...	1982	6801025
typical or atypical mycobacteria?		1981	6801836
immunogenetics of susceptibility to leprosy, tuberculosis, and leishmaniasis. an epidemiological perspective.	the literature on the genetic regulation of susceptibility in leprosy, tuberculosis, amd leishmaniasis is critically reviewed. of the three groups of diseases, leprosy has received the most attention from the standpoint of human genetics. there is now evidence that genetic factors, some of them hla-linked, play a role in tuberculoid leprosy. however, the evidence leaves considerable room for environmental determinants in addition to genetic background. several twin studies of tuberculosis have f ...	1981	6804402
detection of externally induced impairments in single bacterial cells by laser microbe mass analysis.	applying the laser microbe mass analyzer method (lamma), mass spectra (fingerprints) were taken from single bacterial cells not treated or treated with high temperature, x-irradiation, isonicotinic acid hydrazide (inh), or diaminodiphenylsulfone (dds). spectra of treated cells ("m. lufu," m. tuberculosis h37ra, e. coli) differ from those of controls in that the k+/na+ ratio was smaller and in that the intensities of peaks with m/e greater than 100 were lower. from the results with m. leprae the ...	1982	6804403
[results of bacilloscopy practiced on 360 leprosy patients, treated for over 5 years by sulfone monotherapy and examined at bamako (mali)].		1981	6805233
[clinical and paraclinical aspects of secondary drug resistance to 4-4' diaminodiphenylsulfone in a population of leprosy patients in bamako, republic of mali].		1981	6805234
uptake of 3,4-dihydroxy[3h]phenylalanine by mycobacterium leprae isolated from frozen (-80 degrees c) armadillo tissue.	mycobacterium leprae separated from armadillo tissues stored at -80 degrees c is similar to that from human sources in its ability to take up 3h-labelled 3,4-dihydroxyphenylalanine (dopa). several inhibitors were studied which showed complete or partial inhibition of [3h]dopa uptake. these findings suggest that m. leprae isolated from frozen tissue possesses an active uptake system for [3h]dopa.	1981	6806435
chemotherapy of leprosy for control programmes.		1982	6806990
bacteriology of mycobacterium leprae: state of the art paper.		1982	6810740
pyrolysis mass spectrometry: its applicability to mycobacteriology, including mycobacterium leprae.		1982	6810741
ultrastructure of mycobacterium leprae and other acid-fast bacteria as influenced by fixation conditions.	a procedure using aldehydes, oso4, ca++ and uranyl acetate was selected for study of the fixation of mycobacterium leprae in skin biopsies of leprosy patients. the ultrastructural pattern of recognized normal m. leprae cells fixed by the above procedure was characterized, and was found to be similar to that of other acid-fast bacteria fixed by the same procedure, except for the geometry of the membrane profile. under such fixation conditions, this profile is always asymmetric in in vitro-culture ...	1982	6810742
hla-dr-associated genetic control of the type of leprosy in a population from surinam.	the relationship between hla phenotype and leprosy classification was studied in 73 unrelated patients and 92 healthy controls from a mixed negroid-caucasoid population originating from surinam, south america. heterogeneity in the distribution of hla-dr (but not a, b, and c) was detected between tuberculoid (tt* + bt) leprosy and lepromatous (bl + ll*) leprosy patients (p = 0.024). this heterogeneity appeared to be caused almost exclusively by dr3. most significantly, the frequency of dr3 was ...	1982	6811517
[immunotherapy of leprosy in 1981].		1982	6815984
[2 cases of paucibacillary leprosy resistant to dapsone].	two patients are presented with a primary resistant bt leprosy. diagnosis was made on a clinical base: luck of improvement under supervised sulfone treatment and quick regression of the lesions under a short course of rifampicine (8 weekly doses). the two children lived together with their lepromatous mothers who are suspected of dds resistance. where secondary dds resistance is found only in multibacillary leprosy, primary resistance shows up in all clinical forms of leprosy.	1982	6815986
[prevalence of dapsone-resistant leprosy in burundi. temporary results].		1982	6815995
[current data on the bacteriology of leprosy].	microscopic examination and mouse foot-pad inoculation are the main tools in mycobacterium leprae bacteriology. microscopic examination enables to calculate bacteriological (ib) and morphological (im) indexes. the former scores the density of acid-fast organisms in the lesions and the latter scores their viability since only solidly stained acid-fast organisms are likely to be alive. mouse foot-pad inoculation provides the opportunity for studying the growth curve of m. leprae. alterations of th ...	1982	6815996
[mycobacterial strains adapted to culture from human lepromas. identifying characteristics relative to mycobacterium leprae].		1982	6815997
[morphologic and biologic properties of diphtherroid organisms (ldc) isolated in leprosy].	acid-alcohol-fast bacteria are not always detectable in all leprosy lesions. non acid-fast microorganisms may be associated with acid-fast bacteria. the most frequently isolated strains from leprosy lesions are non acid-fast bacteria, morphologically related to c. diptheirae. hence their designation as diphtheroïds or ldc (leprosy derived corynebacteria). their antigenic structure is more closely related to m. leprae and other mycobacteria than to classical corynebacteria. this leads to the hypo ...	1982	6815998
[comparative bactericidal action of rifampicin alone on m. tuberculosis and m. leprae].		1982	6815999
[resistance of mycobacterium leprae to sulfones (dds) and rifampicin in recurring lepromatous leprosy in martinique and guadeloupe since february 1980].		1982	6816000
[the lymphocyte transformation test using phytohemagglutinin, lepromin and m. leprae in lepromin-negative and positive leprosy: prognostic value compared with that of lepromin].		1982	6816002
[employment of a program in the leprosy campaign in mayotte based on the use of rifampicin and clofazimine].		1982	6818815
replication of mycobacterium leprae in hibernating ground squirrels (citellus tridecemlineatus).	subcutaneous injections of 10(6) acid-fast bacteria from human lepromatous tissue to hibernating ground squirrels (citellus tridecemlineatus) is followed by generalized infection of the animals and spontaneous death. the number of mycobacteria is high in the skin of gs during winter and decreases during summer. animals surviving the first hibernation period invariably die during the second. the number of microorganism in the visceral organs is low at all times. the system of infected hibernating ...	1982	6818816
biochemical studies with leprosy-derived corynebacteria.		1982	6818817
biological properties of diphtheroïd bacteria (ldc) isolated from human leprosy lesions.		1982	6818818
[diphtherimorph germs linked to leprous bacillas].		1982	6819754
ribosomal antigens of mycobacterium leprae.		1982	6819797
is diphenoloxidase a constitutive enzyme in mycobacterium leprae?		1982	6821119
isolation of fastidiously growing mycobacteria from armadillo livers infected with mycobacterium leprae.		1982	6890545
mechanism of action of the folate blocker diaminodiphenylsulfone (dapsone, dds) studied in e. coli cell-free enzyme extracts in comparison to sulfonamides (sa).	the antibacterial activity of dds has been studied in whole cell (e. coli), cell-free folate synthesizing enzyme extracts and compared to effects obtained for sulfonamides (sa). it is shown that dds acts as a synthetase inhibitor in the folate synthesizing enzyme system. dds reacts with the substrate 7,8-dihydro-6-hydroxymethylpterinopyrophosphate to form a 7,8-dihydropteroic acid analog. bacterial growth kinetic studies were performed to test for possible synergistic activity of the analog in c ...	1980	6988345
segmental necrotizing granulomatous neuritis of leprosy.	in leprosy, the occurrence of necrotizing nodular lesions in peripheral nerves is a relatively uncommon complication. despite clinical and gross similarities, there are microscopical differences among groups of such cases, indicating that in all probability different pathogenetic mechanisms are operative. furthermore, the vast majority of such cases are not true abscesses but are characterized by caseous necrosis and granulomatous inflammation. the traditional collective name "nerve abscess" is ...	1980	6988346
vaccination in leprosy--observations and interpretations.		1980	6988347
mechansism of action of dds.		1980	6988348
at twenty years after shepard's method of inoculation of m. leprae in the foot pads of mice.		1980	6988350
naturally occurring leprosy-like disease of wild armadillos: ultrastructure of lepromatous lesions.		1980	6988587
in vitro synthesis of anti-mycobacterial antibodies in biopsies from skin lesions of leprosy patients.	to demonstrate local synthesis of anti-mycobacterium leprae antibodies, biopsies from skin lesions of leprosy patients were cultured in vitro in a medium containing 14c-labeled lysine and isoleucine, and the culture fluids were analyzed by crossed immunoelectrophoresis with intermediate gel and autoradiography. the results show that anti-m. leprae antibodies were synthesized in vitro in the biopsies from the skin lesions of leprosy patients and that the specificity of the locally produced antibo ...	1980	6991410
new dimensions in our understanding of the transmission of leprosy and their impact on priorities in leprosy control.		1980	6991810
borderline tuberculoid leprosy with a 'lepromatous' nodule of the nasal mucosa: a case report.		1980	6991811
thyroxine and leprosy.		1980	6991812
study of evolution of nerve damage in leprosy. part iii--sciatic nerve lesions in mice inoculated with m. leprae with nerve conduction velocity correlates.	non-immunosuppressed swiss mice inoculated with 5000 m. leprae in each hind foot pad were subjected to nerve conduction velocity studies followed by light and electron microscopy and fibre tease of both sciatic nerves at sequential time intervals from the 4th to the 24th month. the conduction velocity was standardized for basal temperature of 35 degrees c and uninoculated mice were used as controls. progressive changes were noted in conduction velocity from the 6th post inoculation month and cor ...	1980	6991814
study of evolution of nerve damage in leprosy. part iv--an assessment.		1980	6991815
intermittent rifampicin therapy in lepromatous leprosy.	a double blind trial involving intermittent administration of rifampicin in addition to daily dds has been undertaken in order to evaluate the efficacy as also the potential dangers of such a regimen. twenty untreated ll cases who were otherwise healthy were included in the study. ten cases received weekly 900 mg rifampicin for 6 weeks in addition to 100 mg daily dds, while the rest were treated likewise but were given similar looking placebo capsules instead of rfp. a nine month follow-up, as a ...	1980	6991816
[treatment of lepromatous hansen disease with a rifampicine-isoprodian association (author's transl)].	thirty lepromatous patients were treated during 3 months. if clinical condition was notably improved, the bacillary index and the morphologic index remained almost un-changed and the histo-pathological features, advanced concurrently to the clinic aspects.	1980	6991851
ultrastructure of cells of the mononuclear-phagocyte series (mps) across the leprosy spectrum.	a systematic ultrastructural study of cells of the mps across the spectrum of leprosy has been carried out. graded changes in macrophage ultrastructure from the lepromatous to the tuberculoid poles have been shown. mycobacteria-filled macrophages in lepromatous leprosy are characterised by long cell processes, whereas in borderline tuberculoid leprosy these cells have a rounded appearance and are mainly characterised by numerous intracellular vacuoles. in borderline leprosy, macrophages have an ...	1980	6993638
myelination around multiple axons in the peripheral nerve. an unusual ultrastructural observation.	electron micrographs have been presented, demonstrating myelin ation around multiple axons. this is an exception from the normal 1:1 relationship of axon to schwann cell in a myelinated peripheral nerve fibre.	1980	6994423
[security measures recommended for the preparation of lepromine: who memorandum].		1980	6994912
activation of the alternative pathway of complement by mycobacteria and cord factor.	the ability of a number of mycobacteria and some of their components to activate complement was examined. mycobacterium bovis bcg (glaxo strain), mycobacterium leprae, mycobacterium lepraemurium, and cord factor activated the alternative pathway of complement in normal human serum and normal and c4-deficient guinea pig sera and generated biologically active products. bcg (pasteur strain) and muramyl dipeptide did not activate complement. the relevance of activation of complement by mycobacteria ...	1980	6995341
striated muscle in four categories of leprosy. ii. fine structural changes.	fine structural changes are described in 21 muscle biopsy specimens from patients with early and established tuberculoid or treated and untreated lepromatous leprosy. the predominant light microscopic finding on paraffin sections of atrophy of the muscle fiber was confirmed in semithin araldite sections, which also revealed considerable degenerative changes in a few or more fibers. these were more clearly seen in ultrathin sections, especially in the lepromatous muscle specimens. the degeneratio ...	1980	6995357
biochemical alteration in cells following phagocytosis of m. leprae--the consequence--a basic concept.	when macrophages from lepromatous leprosy patients are exposed to m. leprae, the macrophages show reduced protein synthesis. such a phenomenon is not seen with macrophages from tuberculoid patients or normal individuals. m. leprae phagocytized by schwann cells affect the incorporation of dna precursor in the cells, leading to failure of schwann cell association with axons in in vitro cultures. these 2 observations form a basis of proposing that basic biochemical events take place when m. leprae ...	1980	6995358