Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| evidence for recruitment of plasmacytoid dendritic cell precursors to inflamed lymph nodes through high endothelial venules. | recruitment of dendritic cells (dcs) to lymph nodes (lns) is pivotal to the establishment of immune response. whereas dcs have been proven to undergo afferent lymphatic pathway to enter lns from peripheral tissues, a question remains if dcs also migrate into lns directly from the circulation. here we demonstrate that plasmacytoid dc (pdc) precursors can transmigrate across high endothelial venules (hevs) of inflamed lns in mice. bacterial infection induces a significant number of pdc and myeloid ... | 2004 | 15159375 |
| antimicrobial activities of eucalyptus leaf extracts and flavonoids from eucalyptus maculata. | we investigated the antimicrobial activities of eucalyptus leaf extracts to find effective antibacterial agents. | 2004 | 15189289 |
| evidence for diversity within propionibacterium acnes: a comparison of the t-cell stimulatory activity of isolates from inflammatory acne, endocarditis and the laboratory. | propionibacterium acnes is primarily associated with the pathogenesis of acne vulgaris but reports are increasing in number implicating p. acnes in other diseases such as abscess formation, meningitis and endocarditis. the pathogenicity of p. acnes is thought to be partly due to the interaction of the bacterium with the immune system. historically, investigations have focused on humoral and cell-mediated immune responses to p. acnes antigens without attention to the possibility that different an ... | 2004 | 15196160 |
| the role of pulsed light and heat energy (lhe) in acne clearance. | propionibacterium acnes synthesize and store a large amount of porphyrins. once the porphyrin is exposed to visible light it becomes chemically active and transfers to an excited state, resulting in the formation of singlet oxygen, which combines with cell membranes to destroy the p. acnes. this process is dependent on the rate of production of excited porphyrin molecules, which is influenced by the concentration of porphyrins, the concentration of photons, the temperature, and the wavelength of ... | 2004 | 15203999 |
| antibiotic resistance in the topical treatment of acne vulgaris. | topical antimicrobial agents are the first line of treatment in mild to moderate acne vulgaris. the primary pathogenic agent implicated in the development of inflammatory acne is propionibacterium acnes. p acnes also may play a secondary role in noninflammatory acne or comedogenesis. over the past 20 years, concern has grown about the gradual worldwide increase in the prevalence of antibiotic-resistant p acnes strains. factors associated with the development of resistant p acnes following treatm ... | 2004 | 15228128 |
| roles of cd14 in lps-induced liver injury and lethality in mice pretreated with propionibacterium acnes. | the mechanism of the liver damage and lethality in propionibacterium acnes (p. acnes)-lps system remains obscure. to examine the role of cd14 in the system, m14m mice, in which cd14 was expressed heterotopically under the control of the metallothionein promoter were used. the production of soluble cd14 (scd14) was increased by both p. acnes - priming and lps challenge (1 microg per mouse) in both nontransgenic and m14m mice, although the plasma level was much higher in m14m nontransgenic than mi ... | 2004 | 15234535 |
| propionibacterium acnes causing delayed subdural empyema - a case report and review of literature. | the authors report a patient who presented with a delayed subdural empyema caused by propionibacterium acnes following excision of a meningioma. this organism should be suspected in all patients with delayed empyema especially in the presence of implants and immunosuppression. the main features of this pathogen is discussed. surgical drainage and high-dose intravenous penicillin should be the recommended therapy. | 2004 | 15261253 |
| validation of bact/alert plastic culture bottles for use in testing of whole-blood-derived leukoreduced platelet-rich-plasma-derived platelets. | bacterial detection of platelet (plt)-rich-plasma (prp)-derived plts presents unique challenges for countries that do not allow pooling before storage. this study validated the bact/alert for use in testing pooled prp-derived plts with nine contaminating organisms. | 2004 | 15265121 |
| acne update: 2004. | acne vulgaris is a common skin disorder among children and young adults that carries enormous financial and psychosocial impact. contemporary therapies attempt to address factors underlying acne as a disorder of the pilosebaceous unit. these longstanding paradigms regarding pathogenesis and treatment continue to evolve in light of recent work on this ubiquitous disease. | 2004 | 15273498 |
| indigenous pulmonary propionibacterium acnes primes the host in the development of sarcoid-like pulmonary granulomatosis in mice. | although many cases of sarcoidosis are self-limiting with spontaneous remission, uncontrolled pulmonary granulomatosis with fibrosis produces intolerable long-term respiratory symptoms in a minority of patients. individuals with chronic pulmonary sarcoidosis require an alternative therapy to corticosteroidal treatment because of its insufficient effectiveness. although many researchers have considered infection as the triggering factor for this disease, the mechanisms by which the candidate caus ... | 2004 | 15277236 |
| the complete genome sequence of propionibacterium acnes, a commensal of human skin. | propionibacterium acnes is a major inhabitant of adult human skin, where it resides within sebaceous follicles, usually as a harmless commensal although it has been implicated in acne vulgaris formation. the entire genome sequence of this gram-positive bacterium encodes 2333 putative genes and revealed numerous gene products involved in degrading host molecules, including sialidases, neuraminidases, endoglycoceramidases, lipases, and pore-forming factors. surface-associated and other immunogenic ... | 2004 | 15286373 |
| in vitro antibacterial and anti-inflammatory effects of honokiol and magnolol against propionibacterium sp. | honokiol and magnolol, two major phenolic constituents of magnolia sp., have been known to exhibit antibacterial activities. however, until now, their antibacterial activity against propionibacterium sp. has not been reported. to this end, the antibacterial activities of honokiol and magnolol were detected using the disk diffusion method and a two-fold serial dilution assay. honokiol and magnolol showed strong antibacterial activities against both propionibacterium acnes and propionibacterium gr ... | 2004 | 15288590 |
| benzoyl peroxide-based combination therapies for acne vulgaris: a comparative review. | benzoyl peroxide, with its broad-spectrum antimicrobial activity, is among the most widely used topical agents in the treatment of inflammatory acne vulgaris. benzoyl peroxide is marketed either alone or in combination with other topical antibiotics; namely, erythromycin and clindamycin. the combination products confer specific advantages over benzoyl peroxide alone, particularly in decreasing the in vivo follicular counts of propionibacterium acnes, the anaerobic bacterium implicated in the pat ... | 2004 | 15301572 |
| [microbiology of acute exacerbation chronic sinusitis in adults]. | the bacterial flora taken by sinus puncture from 115 patients with uni and bilateral acute exacerbation of chronic maxillary sinusitis was analyzed. germ-free culture was obtained in 49 cases (40%) and in 69 cases (60%) bacteria were isolated from all sinus aspirates. microbiological evaluation shows, that in majority of cases (90%) of acute exacerbation of chronic sinusitis there were pathogenic bacteria namely aerobic and anaerobic. the most frequent pathogens isolated from the aspirates were; ... | 2004 | 15307480 |
| propionibacterium acnes endocarditis on an annuloplasty ring in an adolescent boy. | propionibacterium acnes, a constituent of the human cutaneous flora, infected both the native mitral valve and a carpentier mitral annuloplasty ring in an adolescent patient. in the case of culture negative endocarditis, the incubation period of blood cultures should be prolonged to identify this pathogen. | 2004 | 15310725 |
| increased interleukin-10 associated with low il-6 concentration correlated with greater survival rates in mice infected by rabies virus vaccinated against it and immunomodulated with p. acnes. | macrophage activity, cytokines serum concentration, serum neutralizing antibodies and lethality by rabies were evaluated in swiss mice experimentally infected with street rabies virus and submitted or not to antirabies vaccination and immunomodulation with p. acnes. animals were killed at different times and serum was collected in order to evaluate cytokines concentration; peritonial and splenic macrophages were collected for macrophage activity evaluation. greater survival rates higher il-10 an ... | 2004 | 15325513 |
| beta-lactamase production and antimicrobial susceptibility of subgingival bacteria from refractory periodontitis. | this study assessed the extent of beta-lactamase-producing bacteria in subgingival plaque samples obtained from 25 patients with refractory marginal periodontitis in the usa. beta-lactamase-positive isolates were characterized using commercial diagnostic kits and partial sequencing of the 16s rrna gene. the susceptibilities to different antimicrobial agents were tested and, in addition, the isolates were screened for the presence of extended spectrum beta-lactamases (esbls). beta-lactamase-produ ... | 2004 | 15327642 |
| distal catheter obstruction from non-infectious cause in ventriculo-peritoneal shunted children. | in hydrocephalic children, ventriculo-peritoneal shunting is the preferred treatment with few complications. however, an obviously non-infectious peritoneal reaction to the cerebrospinal fluid (csf) may occasionally lead to shunt malfunction. in eight hydrocephalic children, shunt malfunction with distal catheter complication was found with abdominal pseudocyst formation in seven cases and accumulation of the csf in one. all children had a normal csf cell count and glucose concentration, and whi ... | 2004 | 15343464 |
| selective priming to toll-like receptor 4 (tlr4), not tlr2, ligands by p. acnes involves up-regulation of md-2 in mice. | lipopolysaccharide (lps) triggers cytokine production through toll-like receptor 4 (tlr4), which shares downstream signaling pathways with tlr2. we investigated the roles of tlr2 and tlr4 in propionibacterium acnes (p. acnes)-primed, lps-induced liver damage using selective tlr ligands. stock lps induced interleukin 8 in both tlr4- and tlr2-expressing human embryonic kidney (hek) 293 cells. purified lps (tlr4 ligand) activated hek/tlr4 cells, while peptidoglycan and lipoteichoic acid (tlr2 ligan ... | 2004 | 15349893 |
| antibody response to crude cell lysate of propionibacterium acnes and induction of pro-inflammatory cytokines in patients with acne and normal healthy subjects. | propionibacterium acnes (p. acnes) plays an important role in the disease pathogenesis of acne vulgaris, a disorder of pilosebaceous follicles, seen primarily in the adolescent age group. in the present study, the presence of antibodies against p. acnes (mtcc1951) were detected in acne patient (n=50) and disease free controls (n=25) using dot-elisa and western blot assay. the ability of p. acnes to induce pro-inflammatory cytokines by human peripheral blood mononuclear cells (pbmcs), obtained fr ... | 2004 | 15357305 |
| inducible histamine protects mice from p. acnes-primed and lps-induced hepatitis through h2-receptor stimulation. | inducible histamine and histamine h2-receptors have been suggested to be involved in innate immune response. | 2004 | 15362044 |
| topical aminolaevulinic acid-photodynamic therapy for the treatment of acne vulgaris: a study of clinical efficacy and mechanism of action. | acne affects 83-95% of 16-year-olds of both sexes, and many seek help from a clinician. emerging problems with conventional acne treatments, specifically antibiotic resistance of propionibacterium acnes and fears over the safety and tolerance of oral isotretinoin, create a demand for novel treatment modalities in acne. | 2004 | 15377348 |
| some like it hot. | 2004 | 15378808 | |
| the pathophysiology of acne vulgaris in children and adolescents, part 1. | microcomedones, the earliest lesions of acne, appear at adrenarche, which typically occurs at about 8 years of age when androgens of adrenal origin begin to stimulate follicular hyperkeratosis and sebaceous hyperplasia in pilosebaceous units on the face. comedones appear about 2 years later, when androgens of gonadal origin are produced and colonization of follicles by propionibacterium acnes increases. inflammatory lesions, such as pustules, papules, and nodules, are the result of the host's im ... | 2004 | 15379361 |
| a status report on the use of subantimicrobial-dose doxycycline: a review of the biologic and antimicrobial effects of the tetracyclines. | 2004 | 15379364 | |
| photochemical treatment of platelet concentrates with amotosalen and long-wavelength ultraviolet light inactivates a broad spectrum of pathogenic bacteria. | bacterial contamination of platelet (plt) concentrates can result in transfusion-transmitted sepsis. a photochemical treatment (pct) process with amotosalen hcl and long-wavelength ultraviolet light (uva), which cross-links nucleic acids, was developed to inactivate bacteria and other pathogens in plt concentrates. | 2004 | 15383024 |
| activity of nadifloxacin (opc-7251) and seven other antimicrobial agents against aerobic and anaerobic gram-positive bacteria isolated from bacterial skin infections. | the in vitro activity of nadifloxacin (opc-7251), a novel topical fluoroquinolone, was assessed and compared with those of ofloxacin, oxacillin, flucloxacillin, cefotiam, erythromycin, clindamycin, and gentamicin against 144 gram-positive bacteria: 28 staphylococcus aureus, 10 streptococcus spp., 68 coagulase-negative staphylococci (cns), 36 propionibacterium acnes, and 2 propionibacterium granulosum strains. all strains originated from bacterial-infected skin disease and were isolated from pati ... | 2004 | 15452398 |
| involvement of cd14 in lipopolysaccharide- induced liver injury in mice pretreated with propionibacterium acnes. | the aim of this study was to elucidate the role of cd14 in the propionibacterium acnes-lipopolysaccharide (lps) system. | 2004 | 15459483 |
| a study on the characterization of corynebacterium acnes. | forty-nine strains of anaerobic gram-positive rods were used in a systematic study of their biochemical and physiological reactions and morphological characteristics and were also subjected to gas chromatographic analyses in an effort to classify them as strains of corynebacterium acnes (c. acnes). the strains were isolated both from lesions in acne vulgaris and from normal skin. according to their biochemical and physiological characters, these 49 strains were divided into six subgroups (subgro ... | 1977 | 15461349 |
| antimicrobial activity of mahonia aquifolium crude extract and its major isolated alkaloids. | the crude extract of mahonia aquifolium (pursh) nutt. stem bark and its two main protoberberine alkaloids, berberine and jatrorrhizine, were tested for their in vitro antimicrobial activity. twenty strains of coagulase-negative staphylococci and 20 strains of propionibacterium acnes isolated from skin lesions of patients with a severe form of acne, and 20 strains of candida sp. isolated from chronic vulvovaginal candidoses were tested for their susceptibility to crude extract and two isolated al ... | 2004 | 15476315 |
| topical antibacterial therapy for acne vulgaris. | topical antibiotics and benzoyl peroxide, are the two main topical antibacterial treatments indicated for mild-to-moderate acne vulgaris. topical antibiotics act both as antibacterial agents suppressing propionibacterium acnes in the sebaceous follicle and as anti-inflammatory agents. benzoyl peroxide is a powerful antimicrobial agent that rapidly destroys both bacterial organisms and yeasts. topical clindamycin and erythromycin have been proven to be effective against inflammatory acne vulgaris ... | 2004 | 15481998 |
| endophthalmitis after intravitreal injection of frozen preprepared tissue plasminogen activator (tpa) for pneumatic displacement of submacular hemorrhage. | 2004 | 15492643 | |
| the pathophysiology of acne vulgaris in children and adolescents, part 2: tailoring treatment. | various pathophysiologic factors are involved in the development of acne lesions, microcomedones, comedones, and inflammatory lesions. these factors include follicular hyperkeratosis, increased colonization of follicles by propionibacterium acnes, increased sebum production, and inflammatory mediators. optimal treatment of acne involves the use of agents that address these various underlying pathogenetic factors. | 2004 | 15499761 |
| retrospective case review of capsular contracture after two-stage breast reconstruction: is colonization of the tissue expander pocket associated with subsequent implant capsular contracture? | periprosthetic capsular contracture is a common problem associated with implant-based breast reconstruction. the purpose of this study was to determine if bacterial colonization of the tissue expander contributes to contracture of the permanent implant. medical records were reviewed for 86 patients (124 tissue expanders) between 1997 and 2001 in 1 institution. three specimens taken from the expander were cultured. the overall incidence of colonization was 42.7%; 49.4% (38.8-60.0) of immediate an ... | 2004 | 15502455 |
| abscess formation within cerebellar metastatic carcinoma--report of two cases and review of the literature. | the occurrence of an abscess in conjunction with a tumor in the brain is very rare. only presumptions exist about their origin and manner of dissemination. preoperative discrimination between a brain tumor with cystic degeneration and a brain abscess within a tumor may be difficult or even impossible. the purpose of this report is to demonstrate the difficulty of such discrimination using conventional ct diagnostics alone. | 2004 | 15506313 |
| late onset posttraumatic propionibacterium acnes endophthalmitis. | to report a case of late onset posttraumatic endophthalmitis secondary to propionibacterium acnes infection. | 2004 | 15506609 |
| [characteristics of the propionibacterium strains isolated from acne patients]. | propionibacterium acnes is a component of physiological flora of human skin. it colonizes the outlets of sebaceous glands and participates in the pathogenesis of inflammatory acne. acne vulgaris is a common skin disease. it is found in more or less exacerbated form in approximately 85% of adolescent population. the main purpose of the research was to confirm the hypothesis of propionibacterium bacteria participation in the aetiopathogenesis of acne vulgaris. the researches have proved the presen ... | 2004 | 15524399 |
| propionibacterium acnes endophthalmitis with bacterial sequestration in a molteno's implant after cataract extraction. | to report a case of propionibacterium acnes endophthalmitis following uncomplicated cataract extraction with bacterial sequestration in a preexisting molteno's drainage implant. | 2004 | 15531335 |
| 420 nm intense continuous light therapy for acne. | topical antibiotics, isotretinoin or systemic antibiotics are usually used for acne therapy. however, isotretinoin cannot be used during pregnancy because it can cause significant birth defects while systemic antibiotics can have adverse side effects such as gastrointestinal irritation, photosensitivity and tetracycline sensitivity. describe here is a high-intensity, narrow-band, blue light (clearlight) system, and its therapeutic clinical effect is investigated on acne using cutaneous measureme ... | 2004 | 15545101 |
| acne and sebaceous gland function. | the embryologic development of the human sebaceous gland is closely related to the differentiation of the hair follicle and the epidermis. the number of sebaceous glands remains approximately the same throughout life, whereas their size tends to increase with age. the development and function of the sebaceous gland in the fetal and neonatal periods appear to be regulated by maternal androgens and by endogenous steroid synthesis, as well as by other morphogens. the most apparent function of the g ... | 2004 | 15556719 |
| acne and propionibacterium acnes. | the involvement of microorganisms in the development of acne has a long and checkered history. just over 100 years ago, propionibacterium acnes (then known as bacillus acnes) was isolated from acne lesions, and it was suggested that p. acnes was involved in the pathology of the disease. the 1960s saw the use of antibiotics to treat acne, and the consequent clinical success combined with reductions in p. acnes gave new impetus to the debate. over the past two decades, the inevitable emergence of ... | 2004 | 15556721 |
| acne: inflammation. | the inflammatory stage of acne vulgaris is usually of greatest concern to the patient. a number of morphologically different inflammatory lesions may form that can be painful and unsightly. in 30% of patients, such lesions lead to scarring(1). inflammatory acne and acne scarring can have significant psychological effects on the patient, including depression, anxiety, and poor self-image(2). although inflammatory acne has been well characterized clinically, the mechanisms by which inflammatory le ... | 2004 | 15556722 |
| acne: topical treatment. | acne vulgaris is a common skin disease, affecting about 70-80% of adolescents and young adults. it is a multifactorial disease of the pilosebaceous unit.(1) the influence of androgens at the onset of adolescence leads to an enlargement of the sebaceous gland and a rise in sebum production. additional increased proliferation and altered differentiation of the follicular epithelium eventually blocks the pilosebaceous duct, leading to development of the microcomedo as the primary acne lesion. conco ... | 2004 | 15556726 |
| single species biofilm-forming ability of root canal isolates on gutta-percha points. | the participation of bacterial biofilms in the over-filled gutta-percha points associated with refractory periapical periodontitis has recently been reported. this study investigated the initial biofilm-forming ability of root canal isolates (enterococcus faecalis, streptococcus sanguis, strep. intermedius, strep. pyogenes, staphylococcus aureus, fusobacterium nucleatum, propionibacterium acnes, porphyromonas gingivalis and prevotella intermedia) on gutta-percha points in vitro. each bacterial s ... | 2004 | 15560836 |
| inactivation of gram-negative and gram-positive bacteria in red cell concentrates using inactine pen110 chemistry. | the risk of transfusion-transmitted bacterial infections as a result of the presence of bacteria in blood is one of the major concerns in transfusion medicine. the purpose of this study was to investigate whether bacteria inoculated into red blood cell concentrates can be inactivated by the inactine pen110 pathogen-reduction process. four bacterial species were chosen for the study: anaerobic gram-positive clostridium perfringens and propionibacterium acnes, known to be transfusion-transmitted; ... | 2004 | 15569065 |
| anaerobic, non-sporulating, gram-positive bacilli bacteraemia characterized by 16s rrna gene sequencing. | owing to the difficulties in identifying anaerobic, non-sporulating, gram-positive bacilli in clinical microbiology laboratories, the epidemiology and clinical spectrum of disease of many of these bacteria have been poorly understood. the application of 16s rrna gene sequencing in characterizing bacteraemia due to anaerobic, non-sporulating gram-positive bacilli during a 4-year period is described. the first case of olsenella uli bacteraemia, in a patient with acute cholangitis, is also reported ... | 2004 | 15585505 |
| in vitro activities of cefotaxime, vancomycin, quinupristin/dalfopristin, linezolid and other antibiotics alone and in combination against propionibacterium acnes isolates from central nervous system infections. | to evaluate the antibiotic susceptibilities of propionibacterium acnes isolates from central nervous system (cns) infections to agents used in current treatment regimens. | 2004 | 15590714 |
| successful recovery of infective endocarditis-induced rapidly progressive glomerulonephritis by steroid therapy combined with antibiotics: a case report. | the mortality rate among patients with infective endocarditis, especially associated with the presence of complications or coexisting conditions such as renal failure and the use of combined medical and surgical therapy remains still high. prolonged parenteral administration of a bactericidal antimicrobial agent or combination of agents is usually recommended, however, the optimal therapy for infective endocarditis associated with renal injury is not adequately defined. | 2004 | 15610562 |
| microbiology of chronic hyperplastic sinusitis. | patients with chronic hyperplastic sinusitis (chs) form a heterogeneous group with similar symptoms and similar treatment despite of possible different mechanisms behind the disease. in the present study we focused on the microbiological findings in chs and compared these results to the patient history in order to find out a possible explanation for the aetiology and chronicity of chs. | 2004 | 15626254 |
| tlr ligands can activate dendritic cells to provide a myd88-dependent negative signal for th2 cell development. | during infection, cd4(+) th cell responses polarize to become primarily th1 or th2. th1 cells, which make ifn-gamma, are crucial for immunity to many bacterial and protozoal infections, whereas th2 cells, which make il-4, il-5, and il-13, are important for resistance to helminth infections. polarized th1 responses are induced by dendritic cells (dcs), which respond to pathogen-derived tlr ligands to produce il-12 and related cytokines that are instrumental in th1 cell outgrowth, and coordinately ... | 2005 | 15634894 |
| propionibacterium acnes types i and ii represent phylogenetically distinct groups. | although two phenotypes of the opportunistic pathogen propionibacterium acnes (types i and ii) have been described, epidemiological investigations of their roles in different infections have not been widely reported. using immunofluorescence microscopy with monoclonal antibodies (mabs) qubpa1 and qubpa2, specific for types i and ii, respectively, we investigated the prevalences of the two types among 132 p. acnes isolates. analysis of isolates from failed prosthetic hip implants (n = 40) reveale ... | 2005 | 15634990 |
| [how i treat... belgian consensus document on the treatment of acne]. | this article describes the consensus on the treatment of acne, reached by a belgian working group. an effective treatment has to rely as much as possible on the pathophysiologic factors: the increased production of sebum, the abnormal desquamation (retention hyperkeratosis) of the epithelium of he sebaceous gland, the proliferation of propionibacterium acnes and inflammation. the therapeutic arsenal contains topical as well as systemic drugs. this consensus gives an overview of both modalities a ... | 2004 | 15646735 |
| newer therapies for cutaneous sarcoidosis: the role of thalidomide and other agents. | skin involvement occurs in a third of patients with sarcoidosis. the type of lesions can range from the transient erythema nodosum to the chronic facial lesion lupus pernio. for some patients with sarcoidosis, lesions on the face or elsewhere on the body may be the major or only indication for therapy. these lesions are often chronic and the use of corticosteroids may lead to more long-term complications. conventional alternatives to corticosteroids include antimalarial agents, methotrexate, and ... | 2004 | 15663335 |
| [human beta defensins: a new perspective in acne treatment?]. | 2005 | 15678389 | |
| successful management of central nervous system infection due to propionibacterium acnes with vancomycin and doxycycline. | propionibacterium acnes is an infrequent but increasingly recognized cause of neurosurgical infections. in this setting, it has been most commonly reported as complicating neurosurgical shunt procedures. the optimum therapy for central nervous system infections caused by p. acnes has not been established. the authors report on a patient who had development of p. acnes central nervous system infection after craniotomy for subdural hematoma. this case was successfully treated with prolonged therap ... | 2005 | 15678647 |
| enhanced resistance to gram-positive bacterium and increased susceptibility to bacterial endotoxin in mice sensitized with propionibacterium acnes: involvement of toll-like receptor. | mice sensitized with propionibacterium acnes showed an enhanced resistance against infection with listeria monocytogenes in contrast to the increased susceptibility to lps-induced endotoxin shock. the enhanced protection to l. monocytogenes was mediated by activated innate immunity but not by generation of listeria-specific acquired immunity. after infection with l. monocytogenes, the elimination of bacteria was observed earlier in accordance with a higher level of endogenous cytokine production ... | 2005 | 15681160 |
| [study on anti-bacterium activity of ginkgolic acids and their momomers]. | ginkgolic acids and their three monomers were separated from ginkgo sarcotestas. the anti-bacterium activity of ginkgolic acids were tested. the relation between the anti-bacterium activity and side chain of ginkgolic acid were studied. | 2004 | 15704587 |
| european surveillance study on the antibiotic susceptibility of propionibacterium acnes. | propionibacterium acnes strains are recovered from infections linked to surgical procedures, foreign bodies and septicaemia. this study investigated the antibiotic susceptibility patterns of p. acnes isolates from different systemic infections and determined the genomic diversity among resistant p. acnes isolates with low-frequency restriction analysis of chromosomal dna by pulsed-field gel electrophoresis (pfge). in total, 304 p. acnes isolates from 13 laboratories in 13 european countries were ... | 2005 | 15715718 |
| mixing glycolic acid with retinaldehyde: ralga, a technical achievement. | the use of retinaldehyde or glycolic acid was found to be effective in topical acne treatments. | 2005 | 15724101 |
| cutting edge: all-trans retinoic acid down-regulates tlr2 expression and function. | a major consequence of microbial infection is the tissue injury that results from the host inflammatory response. in acne, inflammation is due in part to the ability of propionibacterium acnes to activate tlr2. because all-trans retinoic acid (atra) decreases inflammation in acne, we investigated whether it regulates tlr2 expression and function. treatment of primary human monocytes with atra led to the down-regulation of tlr2 as well as its coreceptor cd14, but not tlr1 or tlr4. the ability of ... | 2005 | 15728448 |
| [the study of the pro-nucleating activity of bacteria identified in cholesterol gallstones in model bile systems]. | to explore the relationship of bacteria identified in cholesterol gallstones and gallstone formation. | 2004 | 15733482 |
| propionibacterium acnes sacroiliitis abscess: the private role of biopsy. | 2005 | 15737147 | |
| partial posterior capsulectomy through an anterior approach: an intraocular lens retaining technique in the management of presumed propionibacterium acnes endophthalmitis. | 2006 | 15746949 | |
| the potential immunomodulatory effects of topical retinoids. | new research has refined our understanding of the immunopathophysiology of acne. various immune factors, including both innate and adaptive immune responses, have been implicated in the pathophysiology of inflammatory acne. topical retinoids such as tretinoin, adapalene, and tazarotene, exhibit immunomodulatory effects that may help to explain their efficacy in the resolution of inflammatory lesions. | 2005 | 15748544 |
| exacerbation of granuloma formation in il-1 receptor antagonist-deficient mice with impaired dendritic cell maturation associated with th2 cytokine production. | dendritic cell (dc) maturation at the site of inflammation and migration into draining lymph nodes is fundamental to initiate ag-specific immune responses. although several proinflammatory cytokines, including il-1, are known to promote dc maturation in vitro, their contributions to dc activation and migration within peripheral inflamed tissue compartments are not yet fully understood. we show here that endogenous il-1 receptor antagonist (il-1ra) controls the activation state of liver-recruited ... | 2005 | 15749858 |
| a case of renal sarcoidosis with complement activation via the lectin pathway. | a 57-year-old woman with pulmonary sarcoidosis was admitted to the hospital because of an elevation of serum creatinine and blood urea nitrogen. on admission, the laboratory data suggested interstitial nephritis without proteinuria and hematuria, whereas a renal biopsy showed granulomatous interstitial nephritis and mild mesangial proliferative glomerulonephritis. immunoglobulin and c1q deposits were negative, but mannose-binding lectin, c3, c4d, and c5b-9 deposits were marked in the glomerular ... | 2005 | 15754281 |
| anaerobic spondylodiscitis: case series and systematic review. | bacterial spondylodiscitis is rarely caused by anaerobic organisms. we describe two patients with lumbar vertebral osteomyelitis and discitis caused by anaerobic bacteria, including an unusual occurrence after an endodontic procedure, and review the salient clinical features and outcomes of 31 previously reported cases. | 2005 | 15759942 |
| different pro-inflammatory and immunogenic potentials of propionibacterium acnes and staphylococcus epidermidis: implications for chronic inflammatory acne. | propionibacterium acnes (pa) and staphyloccocus epidermidis (se) are two major bacterial strains isolated from acne lesions. nevertheless, only pa seems to be implicated in the pathogenesis of inflammatory acne vulgaris. evidence for this, however, remains indirect and the precise role of pa in inflammatory acne is still a matter for conjecture. the aim of this study was to compare some pro-inflammatory and adjuvant properties of pa and se. | 2005 | 15761379 |
| requirement for tlr9 in the immunomodulatory activity of propionibacterium acnes. | propionibacterium acnes (formerly corynebacterium parvum) is part of the human flora and, as such, is associated with several human pathologies. it possesses strong immunomodulatory activities, which makes this bacterium interesting for prophylactic and therapeutic vaccination. the bacterial component(s) and the host receptor(s) involved in the induction of these activities are poorly understood. we show in this study that tlr9 is crucial in generating the characteristic effects of killed p. acn ... | 2005 | 15778393 |
| the pathogenesis of acne. | acne vulgaris is a multifactorial disease of as yet incompletely elucidated etiology and pathogenesis. the following have been identified as the most significant factors: follicular hyperkeratosis, increased sebum secretion, propionibacterium (p.) acnes, and inflammation. increased sebum production and follicular hyperkeratosis result in the development of microcomedones, and changes in follicular milieu in intensive growth of p. acnes. p. acnes secretes several proinflammatory products, which p ... | 2005 | 15788147 |
| acne vulgaris: a review of antibiotic therapy. | antibiotic therapy has been integral to the management of inflammatory acne vulgaris for many years. systemic antibiotics work via antibacterial, anti-inflammatory and immunomodulatory modes of action, and have been found to be useful in managing moderate-to-severe acne. commonly prescribed antibiotics include tetracyclines, erythromycin and trimethoprim, with or without sulfamethoxazole. in selecting the appropriate antibiotic for patients needing to receive topical or systemic antibiotic thera ... | 2005 | 15794732 |
| nadifloxacin, an antiacne quinolone antimicrobial, inhibits the production of proinflammatory cytokines by human peripheral blood mononuclear cells and normal human keratinocytes. | acne vulgaris is a chronic inflammatory disease involving colonization of propionibacterium acnes (p. acnes), activation of neutrophils and lymphocytes. circumstantial evidence suggests that antigen-independent and -dependent immune responses against p. acnes are involved in the pathogenesis of inflammatory acne. epidermal keratinocytes are also suggested to be involved in initiation and progression of cutaneous inflammation. nadifloxacin, a fluorinated quinolone, has potent antimicrobial activi ... | 2005 | 15795123 |
| formulation and evaluation of an effective ph balanced topical antimicrobial product containing tea tree oil. | the effect of ph on the antimicrobial activity of melaleuca alternifolia essential oil formulations was studied. microemulsions, liposomal dispersions, multiple emulsions and a colloidal bed of sterile clay were formulated using 5% w/w of tea tree oil. a number of formulations were prepared at various ph values (5.0, 5.5, 6.0, 6.5, and 7.0). thermal stability studies showed that the formulations were stable for more than eight months. agar dilution tests showed mics of 1.0% v/v s. aureus and s. ... | 2005 | 15801675 |
| incidence of bacteremia after routine tooth brushing. | the american heart association first developed recommendations on antibiotic prophylaxis against infective endocarditis during dental procedures more than 50 years ago. these recommendations were partly based on the fact that bacteremia occurs with dental procedures. previous studies in the 1970s and earlier demonstrated that patients become bacteremic after tooth brushing. improved culture techniques suggest that these rates could be higher now. the objective of this study was to determine the ... | 2005 | 15832100 |
| late implant infections caused by propionibacterium acnes in scoliosis surgery. | one hundred and one consecutive adolescent scoliosis patients instrumented from the posterior between 1995 and 2002, with a minimum follow-up of 24 months (maximum 106 months), were reviewed for incidence of infection. stainless steel implants with pedicle screws were used in the thoracic and lumbar spine of all patients. all were operated on by a single surgeon. there were no early infections. incidence of late infection was 6.9% (seven patients). clinical indicators for infection were the sudd ... | 2005 | 15841406 |
| distinct strains of propionibacterium acnes induce selective human beta-defensin-2 and interleukin-8 expression in human keratinocytes through toll-like receptors. | acne is a chronic inflammatory disease of the pilosebaceous follicle. one of the main pathogenetic factors in acne is the increased proliferation of propionibacterium acnes (p. acnes) in the pilosebaceous unit. we investigated whether direct interaction of p. acnes with keratinocytes might be involved in the inflammation and ductal hypercornification in acne. the capacities of different p. acnes strains to activate the innate immune response and the growth of cultured keratinocytes were investig ... | 2005 | 15854033 |
| anti-inflammatory effects of magnolol and honokiol are mediated through inhibition of the downstream pathway of mekk-1 in nf-kappab activation signaling. | propionibacterium acnes, an anaerobic pathogen, plays an important role in the pathogenesis of acne and seems to initiate the inflammatory process by producing proinflammatory cytokines. in order to demonstrate the anti-inflammatory effects and action mechanisms of magnolol and honokiol, several methods were employed. through dpph and sod activity assays, we found that although both magnolol and honokiol have antioxidant activities, honokiol has relatively stronger antioxidant activities than ma ... | 2005 | 15856410 |
| camp factor homologues in propionibacterium acnes: a new protein family differentially expressed by types i and ii. | analysis of the draft genome sequence of the opportunistic pathogen propionibacterium acnes type strain nctc 737 (=atcc 6919) revealed five genes with sequence identity to the co-haemolytic christie-atkins-munch-peterson (camp) factor of streptococcus agalactiae. the predicted molecular masses for the expressed proteins ranged from 28 to 30 kda. the genes were present in each of the three recently identified reca-based phylogenetic groupings of p. acnes (ia, ib and ii), as assessed by pcr amplif ... | 2005 | 15870447 |
| propionibacterium acnes associated with inflammation in radical prostatectomy specimens: a possible link to cancer evolution? | inflammation is commonly observed in the prostate gland and has been implicated in the development of prostate cancer. the etiology of prostatic inflammation is unknown. however, the involvement of a carcinogenic infectious agent has been suggested. | 2005 | 15879794 |
| propionibacterium acnes is the most common bacterium commensal in peripheral lung tissue and mediastinal lymph nodes from subjects without sarcoidosis. | in studies of the unknown etiology of sarcoidosis, propionibacterium acnes (a possible agent) was found in the lungs and lymph nodes of many sarcoidosis patients and some control subjects. p. acnes might be commensal not only to the skin, conjunctivae, and intestine, but also to the lungs and lymph nodes of individuals without sarcoidosis. | 2005 | 15881278 |
| microbial changes in conjunctival flora with 30-day continuous-wear silicone hydrogel contact lenses. | to determine the effect of 30-day continuous-wear silicone hydrogel contact lenses on the conjunctival flora in asymptomatic wearers. | 2005 | 15894879 |
| mechanism-based treatment of acne vulgaris: the value of combination therapy. | acne vulgaris has multiple pathogenic mechanisms that act in concert to produce disease. effective therapy addresses more than one pathogenic factor to speed resolution of disease. typically, retinoids are used to inhibit comedo formation and an antibacterial is used to suppress propionibacterium acnes (p. acnes). using combinations of agents can enhance efficacy, but increase side effects. therefore, the tolerability of a topical retinoid is important. strategies to enhance retinoid tolerabilit ... | 2005 | 15898282 |
| propionibacterium acnes-induced hepatic granuloma formation is impaired in mice lacking tetraspanin cd9. | the granuloma is a host defence response to persistent pathogenic irritants. in the process of granuloma formation, the activation, migration, and fusion of macrophages occur locally, but the mechanisms involved remain elusive. tetraspanins regulate cell migration and fusion by organizing functional molecular complexes in membrane microdomains. here we investigated the role of tetraspanin cd9 in hepatic granuloma formation. immunostaining of the liver of untreated wild-type mice showed that cd9 ... | 2005 | 15902693 |
| endophthalmitis following cataract surgery in southwest finland from 1987 to 2000. | to investigate the incidence, causes, prevention, treatment and outcome of postoperative endophthalmitis (poe) following cataract surgery in southwest finland from 1987 to 2000. | 2005 | 15906062 |
| effect of zinc gluconate on propionibacterium acnes resistance to erythromycin in patients with inflammatory acne: in vitro and in vivo study. | tetracyclines and macrolide antibiotics have been in use for acne treatment for more than 20 years. since 1992 increasing resistance to these antibiotics, and especially to erythromycin, is reported with propionibacterium acnes. zinc salts have demonstrated their efficacy in inflammatory acne treatment as well as their bacteriostatic activity against propionibacterium acnes. the objective of our work was firstly to determine whether the clinical anti-inflammatory efficacy of zinc salts was alter ... | 2005 | 15908296 |
| infected neonatal cephalohematomas caused by anaerobic bacteria. | to present the microbiological and clinical features of six children with infected cephalohematomas (ic) caused by anaerobic bacteria. | 2005 | 15914351 |
| microbial contamination of hematopoietic progenitor cell grafts-incidence, clinical outcome, and cost-effectiveness: an analysis of 735 grafts. | screening of progenitor cell grafts (marrow, peripheral blood, and cord blood) for microbial contamination is required by the standards of aabb. clinical sequelae from infusion of these contaminated grafts, however, is uncommon. | 2005 | 15934984 |
| postoperative discitis due to propionibacterium acnes: a case report and review of the literature. | no previous report has described a progressive, destructive postoperative discitis requiring operative stabilization due to propionibacterium acnes. the clinical and radiographic features and treatment options associated with discitis due to p acnes are presented in a retrospective case study, as well as a review of the current literature. | 2005 | 15936379 |
| induction of interferon-gamma (ifn-gamma) and t helper 1 (th1) immune response by bitter gourd extract. | mice were inoculated intraperitoneally wih 34 different types of vegetable juices, and interferon-gamma (ifn-gamma) and interleukin-4 (il-4) were measured as markers for the induction of th1 and th2 cells, respectively. serum ifn-gamma level was markedly increased in mice inoculated with bitter gourd (momordica charantia) juice, but il-4 levels were not increased with any of the 34 vegetable juices. testing of the various components of bitter gourd, including peel, pulp, and seed, showed that th ... | 2005 | 15942138 |
| the presence of propionibacterium spp. in the vitreous fluid of uveitis patients with sarcoidosis. | an immunological reaction to a bacterial antigen, such as mycobacterium tuberculosis or propionibacterium spp., is suspected to be an initial mechanism in the disorder known as sarcoidosis. we investigated whether or not p. acnes, p. granulosum or m. tuberculosis are present in the vitreous fluid of eyes suffering from uveitis with sarcoidosis. | 2005 | 15948792 |
| phlyctenular keratitis associated with meibomitis in young patients. | to describe the unique clinical features of phlyctenular keratitis, including the association with meibomitis, in young patients. | 2005 | 15953578 |
| [subacute subdural empyema]. | 2005 | 15970172 | |
| the antimicrobial activities of psidium guajava and juglans regia leaf extracts to acne-developing organisms. | this study aims to present the in vitro inhibitory effect of psidium guajava and juglans regia leaf extracts on the main developer of acne lesions, propionibacterium acnes (p. acnes), and other organisms that are isolated from acne lesions. thirty-eight subjects (males and females) who had various types of acne were enrolled in the study. the contents of the acne lesions were cultured and the frequency of p. acnes (alone and with staphylococci spp.) was 47%, whereas the frequencies for staphyloc ... | 2005 | 15974479 |
| helicobacter pylori accumulates photoactive porphyrins and is killed by visible light. | helicobacter pylori colonizes the mucus layer of the human stomach and duodenum, causes chronic gastritis, gastric ulcer, and is a risk factor for gastric adenocarcinoma. there is a 20% failure rate in antibiotic therapy, which is increasingly due to antibiotic resistance and necessitates the search for alternative antimicrobial methods. we have discovered that h. pylori when cultured in liquid medium, accumulates significant quantities of coproporphyrin and protoporphyrin ix, both in the cells ... | 2005 | 15980355 |
| [oral clarithromycin as a treatment option in chronic post-operative endophthalmitis]. | to assess the outcome of medical treatment with oral clarithromycin in patients with chronic post-surgical endophthalmitis. | 2005 | 15986274 |
| superoxide dismutase and myeloperoxidase activities in polymorphonuclear leukocytes in acne vulgaris. | acne vulgaris frequently occurs in the second decade of life. the pathogenesis of the disease is multifactorial and in the present study, we aimed to investigate the role of reactive oxygen species in the inflammation of acne by determining the activities of myeloperoxidase (mpo) and superoxide dismutase (sod) in polymorphonuclear leukocytes (pmn). | 2005 | 16001098 |
| repeat infective endocarditis: differentiating relapse from reinfection. | repeat infective endocarditis due to the same species can represent relapse of the initial infection or a new infection. we used time-based clinical criteria and pulsed-field gel electrophoresis-based molecular criteria to classify 13 cases of repeat infective endocarditis as either relapse or reinfection. the agreement between clinical and molecular criteria was imperfect (agreement in 10 [77%] of 13 cases). | 2005 | 16007540 |
| antimicrobial effects of thai medicinal plants against acne-inducing bacteria. | propionibacterium acnes and staphylococcus epidermidis have been recognized as pus-forming bacteria triggering an inflammation in acne. the present study was conducted to evaluate antimicrobial activities of thai medicinal plants against these etiologic agents of acne vulgaris. crude extracts were tested for antimicrobial activities by disc diffusion and broth dilution methods. the results from the disc diffusion method showed that 13 medicinal plants could inhibit the growth of propionibacteriu ... | 2005 | 16009519 |
| ocular hypersensitivitiy to topical vancomycin in a case of chronic endophthalmitis. | to report a case of ocular allergy to topical vancomycin eye drops. | 2005 | 16015099 |
| flomoxef sodium and levofloxacin concentrations in aqueous humor. | we intravenously administered flomoxef sodium (fmox) 120 minutes before cataract surgery, topically administered levofloxacin (lvfx) into the eyes four times at 30-minute intervals before surgery, and measured the aqueous humor concentrations of these agents to investigate their penetration into the aqueous humor and their efficacy in the prevention of postoperative endophthalmitis. | 2005 | 16019684 |