Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| the relationship of delayed hypersensitivity to acquired antituberculous immunity. ii. effect of adjuvant on the allergenicity and immunogenicity of heat-killed tubercle bacilli. | 1970 | 5002230 | |
| [meningoencephalitis listeriosa]. | 1971 | 5002426 | |
| the relative importance of blood monocytes and fixed macrophages to the expression of cell-mediated immunity to infection. | infection in mice with listeria monocytogenes results in a substantial accumulation of migrant macrophages in the liver. the immigrant cells populate both the infective foci and intervening sinusoids. they have the labeling characteristics of blood monocytes, and their appearance in infective foci in the liver corresponds to the expression of a high level of antimicrobial immunity in this organ. the infected liver acquires additional new macrophages by kupffer-cell division. the proliferation of ... | 1970 | 5002519 |
| the mediator of cellular immunity. i. the life-span and circulation dynamics of the immunologically committed lymphocyte. | thoracic duct cells from rats which have survived an infection with listeria monocytogenes can confer a high level of antimicrobial resistance upon normal recipients. the cells which confer protection appear in the thoracic duct during the 1st wk of the immunizing infection, at a time when newly formed lymphocytes are being added to the lymph in substantially increased numbers. the protective cells differ in at least two respects from the majority of small lymphocytes in central lymph: they have ... | 1971 | 5002521 |
| the mediator of cellular immunity. ii. migration of immunologically committed lymphocytes into inflammatory exudates. | peritoneal exudates from rats which have survived an infection with l. monocytogenes can protect cyclophosphamide-treated recipients against a listeria challenge. they are more effective in this respect than cells obtained from the spleen or thoracic duct lymph. since exudate cells from normal rats and inocula prepared from the resident peritoneal cell populations of infected donors are unable to inhibit the challenge infection, the protective cells must belong to a class of lymphocytes that eme ... | 1971 | 5002522 |
| [model studies using various reagents important in the epidemiology of listeria monocytogenes]. | 1971 | 5003047 | |
| changes induced in the ultrastructure of the cytoplasmic and intracytoplasmic membranes of several gram-positive bacteria by variations in oso 4 fixation. | 1971 | 5003136 | |
| factors neutralizing the bacteriocidal effect of lysolecithin. | 1971 | 5003193 | |
| [opportunistic infections due to listera monocytogenes]. | 1971 | 5003673 | |
| [prophage induction in listeria monocytogenes]. | 1971 | 5003842 | |
| [serological diagnosis of listeriosis with an agglutination reaction on gelose]. | 1971 | 5004042 | |
| brain abscess due to listeria monocytogenes in a patient with cirrhosis of the liver. | 1971 | 5004054 | |
| [various peculiarities in virulence changes of septicemia pathogens during the course of infection]. | 1971 | 5004770 | |
| [coxiella burneti, listeria monocytogenes and toxoplasma gondii antibodies in employees of abbatoirs of campania]. | 1971 | 5004919 | |
| [the kinetics of listeria monocytogenes growth at different temperatures]. | 1971 | 5004956 | |
| some epidemiologic problems of human listeriosis in hungary. | 1971 | 5005044 | |
| [energy metabolism of various aerobic septicemic bacteria with different virulence]. | 1971 | 5005069 | |
| [catalase activity in variations of septicemic bacteria with varying virulence]. | 1971 | 5005070 | |
| [2 cases of listeria meningoencephalitis of medullo-pontine type]. | 1971 | 5005203 | |
| in vitro induction of nonspecific resistance in macrophages by specifically sensitized lymphocytes. | experiments were carried out to determine whether macrophages can be activated in vitro to resist challenge with heterologous microorganisms. sensitized spleen cells from guinea pigs chronically infected with toxoplasma gondii were cultured with normal guinea pig peritoneal macrophages in the presence and absence of toxoplasma antigen. macrophage monolayers incubated with sensitized spleen cells and antigen were markedly resistant to challenge from listeria monocytogenes. resistance was manifest ... | 1971 | 5005299 |
| cytotoxicity of rabbit blood for listeria monocytogenes. | our studies reveal that normal rabbit blood contains a potent bactericidin active against listeria monocytogenes. the factor is present in greatest amounts in fresh undiluted serum but is absent in platelet extracts. a correlation was observed between the virulence of listeria strains and their relative ability to survive in serum. the bactericidal titers obtained for plasma and plasma serum indicate that clotting must occur for optimum expression of antilisterial activity. the lethal action is ... | 1971 | 5005312 |
| ultrastructural patterns of bacterial breakdown in normal and granulomatous rabbit alveolar macrophages. | 1971 | 5005494 | |
| isolation of listeria monocytogenes from brain specimens of domestic animals in ontario. | 1971 | 5005795 | |
| [listeria monocytogenes in bovine brain material]. | 1971 | 5006263 | |
| [demonstration of listeria monocytogenes in culture]. | 1970 | 5006426 | |
| listeria meningitis. | 1968 | 5006478 | |
| a fatal case of listeria monocytogenes meningoencephlitis in a newborn infant. a case report with autopsy and brief review. | 1965 | 5213241 | |
| recurrent listeria monocytogenes meningitis in a patient with acute leukemia. | 1968 | 5238819 | |
| [a listeria monocytogenes infection]. | 1966 | 5332301 | |
| [meningitis due to listeria monocytogenes in cameroon: 1st case]. | 1969 | 5396840 | |
| laboratory studies with a selective enterococcus medium. | lancefield group d streptococci are involved with appreciable frequency in a variety of infectious processes. the presumptive recognition of these bacteria on initial culturing of clinical specimens is an objective not attained readily by selective media available in the clinical laboratory. selective enterococcus agar was evaluated with emphasis on its ability to sequester enterococci from specimens with many microbial components. in addition, the sensitivity of this new agar was compared with ... | 1970 | 5485723 |
| [a case of listeria monocytogenes neonatal meningitis]. | 1970 | 5517240 | |
| suppression of cell-mediated immunity to infection by an antimitotic drug. further evidence that migrant macrophages express immunity. | the development of acquired cell-mediated immunity to infection with listeria monocytogenes can be blocked by a 15 hr pulse of the antimitotic drug, vinblastine (vb). the drug has no effect on the host-parasite relationship after 72 hr of infection when a high level of immunity is being expressed, i.e., when infective foci are populated by activated macrophages. infective foci in mice treated early during infection with vb do not acquire migrant macrophages, but they become acellular after 48 hr ... | 1970 | 5523967 |
| polyacrylamide gel identification of bacterial l-forms and mycoplasma species of human origin. | 1971 | 5544289 | |
| the mediator of cellular immunity. 3. lymphocyte traffic from the blood into the inflamed peritoneal cavity. | a substantial portion of the lymphocyte-like cells in induced peritoneal exudates derive from cells which enter the blood by way of the thoracic duct. the migrant cells have been identified as large and medium lymphocytes, but they may also include short-lived small lymphocytes derived from them. small lymphocytes which have a potentially long circulating life-span are excluded from exudates, although cells of this type predominate in thoracic duct lymph. the results imply that many (perhaps all ... | 1971 | 5547059 |
| [the occurrence of listeria monocytogenes in cattle in niedersachsen]. | 1967 | 5628784 | |
| [studies on the frequency of antibodies agglutinating listeria monocytogenes in population groups of piemonte (turin and cuneo)]. | 1968 | 5711212 | |
| [on the frequency of agglutinating antibodies to listeria monocytogenes in the serum of adult individuals in the province of vercelli]. | 1968 | 5711213 | |
| listeria monocytogenes encephalitis associated with corticosteroid therapy. | a fatal case of listeria monocytogenes septicaemia and encephalitis is described. the infection was associated with steroid therapy given for necrotizing cutaneous vasculitis. agglutinating antibodies were not detectable in the patient's serum. reasons for the failure of apparently appropriate antibiotic therapy are discussed. | 1969 | 5798634 |
| acute meningitis due to listeria monocytogenes. | 1965 | 5827267 | |
| [epidemiological aspects of listeria monocytogenes infections in the newborn]. | 1965 | 5847354 | |
| [suppurative aneurysm with the presence of listeria monocytogenes]. | 1965 | 5849888 | |
| [pneumopathy revealing a septicemia caused by listeria monocytogenes in an adult]. | 1965 | 5850574 | |
| [description of a case of materno-fetal infection from listeria monocytogenes]. | 1965 | 5895367 | |
| [cellular resistance to bacterial infection. iv. active immunization and resistance of the macrophages of ncs mice to the intracellular multiplication of listeria monocytogenes, corynebacterium kutscheri and brucella melitensis]. | 1966 | 5903387 | |
| [cellular resistance to bacterial infection. 3. modifications of the resistance of ncs mice to infection by listeria monocytogenes after endotoxin injection. comparative effects of an endotoxin injection and an active immunization on the morphological aspect and cellular resistance to infection of the macrophages of ncs mice]. | 1966 | 5903404 | |
| [meningitis caused by listeria monocytogenes in an 8-day-old child born by cesarean section]. | 1966 | 5919532 | |
| [histological investigation of pregnant mice following infection with listeria monocytogenes]. | 1966 | 5932977 | |
| antibody responses in experimental infections with listeria monocytogenes. | 1967 | 6020578 | |
| meningitis caused by listeria monocytogenes. | 1967 | 6080003 | |
| ribonuclease-sensitive ribosomal vaccines. | this paper presents an analysis of the protective properties of the components in ribonuclease (rnase)-sensitive ribosomal vaccines, in particular the ribonucleic acid (rna). the protective activities in mice of purified ribosomes derived from pseudomonas aeruginosa and from listeria monocytogenes were compared. both ribosomal vaccines had to be combined with the adjuvant dimethyldioctadecylammonium bromide (dda) in order to be protective, and both lost their activity after rnase treatment. the ... | 1984 | 6084981 |
| microbicidal activity and morphological characteristics of lung macrophages in mycobacterium bovis bcg cell wall-induced lung granuloma in mice. | morphological and functional changes in lung macrophages from mice injected intravenously with mycobacterium bovis bcg cell walls (cws) were studied. in bcg cw high-responder mice (c57bl/6 [b6] strain), an increase in the size and the acid phosphatase activity of lung macrophages was observed. these lung macrophages showed greater microbicidal activity to m. bovis ravenel and listeria monocytogenes egd, enhanced superoxide anion production index, and greater macrophage migration inhibition activ ... | 1984 | 6086525 |
| relationships between oxidative metabolism, macrophage activation, and antilisterial activity. | previous reports from this laboratory have revealed that macrophages obtained from 7-day listeria-immune mice elicited 15 h before harvest with heat-killed homologous microorganisms were able to kill listeria monocytogenes while resident or elicited cells were not [14, 16]. in the present study, experiments were conducted to determine if phagocytosis-associated oxidative metabolic activity participates in the enhanced destruction of listeria by activated macrophages. investigations into producti ... | 1984 | 6090558 |
| rationale for clinical trials evaluating ceftriaxone in the therapy of bacterial meningitis. | ceftriaxone is a promising antimicrobial agent in the therapy of bacterial meningitis. the rationale for the clinical evaluation of ceftriaxone in patients with meningitis is based on the following favorable characteristics: ceftriaxone has excellent in vitro activity (mbc90 0.25 microgram/ml or less) against the major meningeal pathogens including meningococci, pneumococci, group b streptococci, hemophilus influenzae, and escherichia coli, but it is inactive against listeria monocytogenes; ceft ... | 1984 | 6093518 |
| a comparison of ampicillin-cefotaxime and ampicillin-chloramphenicol in childhood bacterial meningitis: an experience in 55 patients. | ampicillin-cefotaxime was tested as initial therapy of presumptive bacterial meningitis in 55 children greater than or equal to 2 months of age at our hospital. during the first year of this ongoing trial, 11 patients, 10 whose csf yielded ampicillin-resistant haemophilus influenzae type b (mic greater than 16 mg/l, beta-lactamase +) and one, indole-negative proteus (mic 4 mg/l), were begun on ampicillin-cefotaxime and then continued on cefotaxime alone. all did well clinically except one who co ... | 1984 | 6094437 |
| listeriosis. | 1980 | 6103466 | |
| immunity to toxoplasma and listeria induced by homologous and heterologous organisms. | cross protection of animals against various organisms have been shown for many years. this type of resistance to phylogenetically unrelated organisms might be attributed to certain immunological phenomena such as non-specific macrophage activation. in this report the cross-protective effect of some organisms against toxoplasma gondii rh strain and listeria monocytogenes is described. groups of mice were immunized with bcg, toxoplasma lysate antigen, viable cysts of t. gondii tehran strain and he ... | 1980 | 6104422 |
| babies cross-infected with listeria monocytogenes. | 1981 | 6117723 | |
| hospital cross-infection with listeria monocytogenes confirmed by phage-typing. | 1981 | 6118543 | |
| [encephalitis due to listeria monocytogenes: a complication of immunosuppressive therapy (author's transl)]. | two cases of encephalitis due to listeria monocytogenes with lethal outcome are presented. the infection occurred during immunosuppressive treatment for panarteritis nodosa and sarcoidosis, respectively. the pathological-anatomical findings were a diffuse purulent meningoencephalitis in the first case and a focal rhombencephalitis with necrotizing inflammation of brainstem and cerebellum in the second one. listerial infections of the adult are gaining increasing importance as severe complication ... | 1982 | 6121753 |
| interleukin 2 induction in lyt 1+ 23- t cells from listeria monocytogenes-immune mice. | peritoneal exudate t lymphocytes from mice experimentally infected with the intracellular bacterium listeria monocytogenes secreted high interleukin 2 activities after interaction with syngeneic normal macrophage presenting listerial antigen in vitro. l. monocytogenes-immune cells secreting il 2 were radioresistant and bore the phenotype thy 1(+) lyt 1(+)23(-). | 1982 | 6127317 |
| genetic control of cell-mediated immunity in rats: involvement of rt1.b locus determinants in the proliferative response of t lymphocytes to listeria antigens. | the cellular requirements for listeria monocytogenes antigen-induced, specific [3h]thymidine incorporation into lymphoid cells were analysed. nylon-nonadherent lymph node and peritoneal exudate cells from infected athymic rats and mice failed to respond by proliferation, whereas control cells of thymus-bearing animals gave significant responses. in mice, cells expressing thy-1 at a high density were required for the initiation of the proliferative response, but cells with lower density also part ... | 1982 | 6128307 |
| [decarboxylase and hemolytic activity in listeria]. | investigated were a great number of listeria monocytogenes strains of 1/2a, 4b, 5, and 6 serotypes for the production of decarboxilase, hemolysin, and pathogenicity for albino mice. it was found that only representatives of 1/2a serotype (40 out of 93 studied strains) produced decarboxilase for glutamic acid. the hemolytic activity was evaluated by means of a spekol after the hemolysis of sheep erythrocytes. a correlation was established between hemolytic activity and pathogenicity, consisting i ... | 1982 | 6129729 |
| failure of synthetic muramyl dipeptide to increase antibacterial resistance. | synthetic muranyl dipeptide, which potentiates antibody production and cellular immune responses at a dosage of 100 to 500 micrograms, did not enhance resistance to intravenous infection with a sublethal dose of 2 x 10(3) to 4 x 10(3) viable listeria monocytogenes cells in mice when intraperitoneally injected either 20 min or 5 days before infection. similarly, blockade of the mononuclear phagocyte system by dextran sulfate 500 could not be overcome by pretreatment with muramyl dipeptide. in con ... | 1980 | 6155329 |
| stimulation of activated rat t cells in vitro by listeria monocytogenes antigens. | a soluble extract of listeria monocytogenes bound firmly and in similar amounts to a variety of rat cells. cells that bound this material differed in their capacity to stimulate the in vitro proliferation of lymphocytes obtained from the thoracic duct of listeria-immune donors. the capacity of cells to serve as antigen-presenting cells in this system coincided or closely overlapped the expression on these cells of an ia antigen-like structure. three lines of evidence indicate that t cells respon ... | 1980 | 6159325 |
| rapid flagella stain. | leifson stain was modified to produce rapid staining of bacterial flagella on untreated microscope slides. the procedure was reliable when tested against a variety of motile and nonmotile bacteria. | 1981 | 6164691 |
| alternative induction of ifn-alpha and ifn-gamma by listeria monocytogenes in human peripheral blood mononuclear leukocyte cultures. | production of interferon (ifn) by listeria monocytogenes (lm) in human peripheral blood mononuclear leukocyte (pbml) cultures was studied. acid-labile ifn-gamma was produced in ficoll-hypaque-purified mononuclear cell cultures in response to heat-killed lm (hk-lm). however, plastic dish (pd)-nonadherent cells produced acid-stable ifn-alpha, whereas the cells reconstituted with pd-adherent cells (m phi) and pd-nonadherent cells produced ifn-gamma by hk-lm, ifn-gamma was produced only in a mixture ... | 1981 | 6164722 |
| immunological memory to listeria monocytogenes in rodents: accumulation of listeria-reactive lymphocytes in the stimulated and unstimulated peritoneal cavity. | 1981 | 6167715 | |
| enhancement of cytotoxicity of human peripheral blood lymphocytes by interferon. | human lung carcinoma cells persistently infected with mumps virus (pc-10/mpv) were lysed with human peripheral blood mononuclear leukocytes (pbml) obtained from seropositive donors who had anti-mumps virus-neutralizing antibody in their sera. this cellular cytotoxicity was due not to the cytotoxic t lymphocytes but mainly to the non-t, non-b cells, possibly related to natural killer (nk) cells. moreover, it was concerned not with antibody against mumps virus antigens but with alpha-interferon (i ... | 1981 | 6169978 |
| t cell-mediated cytotoxicity induced by listeria monocytogenes. i. activation of listeria antigen-responsive t cells. | soon after rats are infected with listeria monocytogenes (lm), listeria antigen- (lma) responsive lymphocytes are delivered to the animal's thoracic duct. these lm-responsive lymphocytes can be restimulated in vitro by lma to generate cells that have a potent cytolytic capability. the activation of lma responsive lymphocytes is immunologically specific and dependent upon the activity of histocompatible accessory cells. neither cell-free lma nor lma-pulsed allogeneic accessory cells can promote a ... | 1981 | 6170698 |
| t cell-mediated cytotoxicity induced by listeria monocytogenes. ii. specificity of cytolytic effector cells. | listeria monocytogenes- (lm) antigen-dependent cytotoxic lymphocytes, identified in a companion manuscript as t cells (ctl), can kill a wide variety of target cells, including syngeneic fibroblasts of both fetal and adult origin, and certain allogeneic and xenogeneic tumor cells. cold target cell inhibition assays revealed that cells susceptible to lysis can block the cytolytic process in a dose-dependent manner, whereas lysis-resistant cells cannot. several lines of evidence indicate that to re ... | 1981 | 6170699 |
| [nonpathogenic listeriae: l. innocua sp. n. (seeliger et schoofs, 1977) (author's transl)]. | in connexion with the separation of listeria innocua (seeliger and schoofs, 1977) from listeria monocytogenes (murray et at., pirie, 1940), resulting epidemiological and epizootological problems are discussed. l. innocua is apathogenic when conventional experimental models for testing listeria monocytogenes are used. under special conditions, i.e. use of suckling mice, strain welshimer of l. innocua produced localized encephalitis (patoĉka et al., 1979). the peculiarities of l. innocua justify f ... | 1981 | 6171948 |
| mac-2, a novel 32,000 mr mouse macrophage subpopulation-specific antigen defined by monoclonal antibodies. | two monoclonal antibodies, m3/31 and m3/38, were obtained by fusion of mouse myeloma cells with rat spleen cells immunized to immunoadsorbent-purified macrophage glycoproteins. co-precipitation experiments show that antigenic determinants recognized by these two antibodies reside on the same molecular species, termed mac-2, mac-2, an antigen of 32,000 mr, is synthesized by and expressed on the surface of thioglycollate-elicited macrophages as shown by [35s]-methionine and 125i labeling. saturati ... | 1982 | 6173426 |
| biological functions of t cell lines with specificity for the intracellular bacterium listeria monocytogenes in vitro and in vivo. | peritoneal exudate t lymphocytes from mice immunized with live listeria monocytogenes were cloned in double-layer soft agar containing heat-killed l. monocytogenes (lower layer) and syngeneic accessory cells (upper layer). colony-derived t cells were propagated in vitro in the presence of listerial antigen, syngeneic accessory cells, and t cell growth factor. in vitro proliferation, interleukin secretion, and bystander help for b cells of six such t cell lines and several sublines derived from t ... | 1982 | 6176667 |
| failure of killed listeria monocytogenes vaccine to produce protective immunity. | 1982 | 6176874 | |
| enhanced production of murine interferon gamma by t cells generated in response to bacterial infection. | spleen cell cultures derived from animals infected 6 d earlier with listeria monocytogenes produced 10-20-fold more murine interferon gamma (muifn gamma) than spleen cells from nonimmune mice in response to stimulation with t cell mitogens. a striking temporal association was found between the enhanced synthesis of muifn gamma and the development of anti-listeria immunity in that both the potential for increased muifn gamma production and the generation of listeria-protective t cells developed a ... | 1982 | 6177817 |
| ctl helper factor(s) produced by peritoneal cells of mice immunized to listeria monocytogenes: relationship to interferon. | we have studied the relationship of interferons (ifn) to soluble helper factor(s) produced in vitro by activated peritoneal exudate cells of mice immunized to listeria monocytogenes. this helper factor(s) can assist the generation of cytotoxic lymphocytes (ctls) in response to allogeneic thymocytes that have been heat-treated to remove functional antigens that would normally stimulate ctls in the absence of added exogenous help. in addition to ifn and ctl helper activity, a thymocyte proliferati ... | 1981 | 6180058 |
| genetic restriction of interferon production in immune response to listeria monocytogenes. | 1982 | 6180099 | |
| macrophage function in senescence. | although the parenteral injection of dextran sulfate 500 (ds 500; 50 mg/kg body weight) into 22-month-old nmri mice resulted in a complete loss of resistance when administered 1 day before the sublethal (4.5 x 10(3)) infection with listeria monocytogenes, the consequences in aged animals were less dramatic than in young adult (2- to 3-month-old) controls. this was documented by prolonged survival times as well as reduced numbers of listeriae in spleen. this indicates that aged mice possess an in ... | 1982 | 6180958 |
| in vitro effect of murine-derived transfer factor on salmonella-specific rosette formation. | the splenic lymphocytes from salmonella-immune icr swiss or c3h/hej mice formed greater than 0.2% antigen-specific rosettes with sheep erythrocytes coated with a spent-medium protein antigen of salmonella typhimurium. these rosette-forming lymphocytes were found to be sensitive to the effects of antithymocyte serum plus complement. transfer factor prepared from the salmonella-immune splenic lymphocytes of icr swiss mice was active in sensitizing nonimmune icr swiss or c3h/hej lymphocytes to form ... | 1982 | 6183216 |
| t-cell subsets induced in listeria monocytogenes-immune mice. ly phenotypes of t cells interacting with macrophages in vitro. | interactions of peritoneal exudate t lymphocytes from listeria-immune mice with macrophages from normal mice in the presence of heat-killed listeriae result in the induction of interleukins. the data show that ly 1+, 23- t cells specific for listeria antigens are essential for interleukin induction and make it likely that, in addition, ly 1+, 23+ t cells are required for optimal responses. | 1982 | 6186015 |
| alternative induction of alpha/beta interferons and gamma interferon by listeria monocytogenes in mouse spleen cell cultures. | production of interferon (ifn) by listeria monocytogenes (lm) in nonimmunized mouse spleen cell cultures was studied. ifn-gamma defined by virtue of its acid stability and antigenicity was produced in spleen cell cultures obtained from ddy mice, c57bl/6 mice, and balb/c mice in response to heat-killed (hk) lm within 24 hr. on the other hand, production of ifn-alpha/beta was demonstrated in spleen cell cultures obtained from one of four nude mice (balb/c, nu/nu). therefore, it is important to kno ... | 1983 | 6187478 |
| effects of various coryneforms on mononuclear phagocyte system function and on production of tumour necrosis factor in mice. | vaccines of 6 strains of the genera corynebacterium and propionibacterium were tested for induction of hepatosplenomegaly and stimulation of clearance of injected colloidal carbon and viable listeria monocytogenes. these effects were compared with the ability of these strains to support the endotoxin-induced liberation of tumour necrosis factor, interferon and heat-stable cytostatic factors in mouse circulation. five strains caused good stimulation of macrophage functions and induced high levels ... | 1983 | 6190428 |
| effect of interferon inducers and purified mouse interferon on the susceptibility of mice to infection with listeria monocytogenes. | 1983 | 6191531 | |
| [interferon induction by proteins as exemplified by a human plasma fraction cryoprecipitate]. | 1983 | 6191730 | |
| [antibiotic therapy in the compromised host--presented as a model for listeriosis in the mouse. ii. effect of tetracycline]. | the effectiveness of tetracycline therapy on listeria-infection in compromised host was evaluated in three different murine models. in normal adult mice infected with a tetracycline susceptible strain of listeria monocytogenes, treatment with this antibiotic caused a reduced rate of multiplication of bacteria. that is, a low bacterial count was found in the spleen. when the macrophage system which in listeria-infection represents a major defense mechanism was blocked through dextran sulfate 500, ... | 1983 | 6194102 |
| anti-viral immune response of allogeneic irradiation bone marrow chimeras: cytotoxic t cell responsiveness depends upon h-2 combination and infectious agent. | allogeneic irradiation bone marrow chimeras c57bl/10 (h-2b) leads to b10.br (h-2k) and b10.br (h-2k) leads to c57bl/10 (h-2b) were raised under specific pathogen-free (spf) conditions; they survived very well and were healthy under spf for 3-4 months and subsequently, under conventional housing conditions, for 1 to 8 months. their immune response against third-party alloantigens was comparable with that of controls. anti-vaccinia virus responses were very low when compared with syngeneic control ... | 1984 | 6198181 |
| murine model for therapy of listeriosis in the compromised host. iii. the effect of rifampicin. | 10 different strains of listeria monocytogenes tested in vitro were found to be susceptible to rifampicin showing minimal inhibitory concentrations between 0.0075 and 0.06 microgram/ml. mice infected with a virulent strain of l. monocytogenes were treated with this antibiotic. bacterial counts rapidly declined. in dextran sulfate-treated animals, deprived of their macrophage system and consequently highly susceptible to listeria infection, rifampicin was able to protect the animals. furthermore, ... | 1984 | 6199164 |
| suppression of bcg cell wall-induced delayed-type hypersensitivity by pretreatment with killed bcg: induction of nonspecific suppressor t cells by the adjuvant portion (mdp) and of specific suppressor t cells by the antigen portion (tap). | we showed previously that antigen-nonspecific suppressor t cells induced by i.v. injection of heat-killed bacillus calmette-guérin (bcg) were involved in suppression of delayed-type hypersensitivity (dth). we suggested that the adjuvant portion of bcg might be involved in the induction of these cells. in this report, we show that bcg cell wall-induced dth responses in mice pretreated with muramyl dipeptide (mdp), a minimum adjuvant constituent of bcg, were suppressed nonspecifically. in addition ... | 1984 | 6202761 |
| suppression of the immune response to listeria monocytogenes. i. immune complexes inhibit resistance. | murine infection with the facultative intracellular pathogen listeria monocytogenes was studied as a model of cell-mediated immunity. overwhelming lethal infection with listeria developed when mice were given a secondary challenge with a protein antigen at the same time as listeria infection. three days after infection, mice immunized with ovalbumin and then challenged with listeria and ovalbumin had up to 2.1(10)6 times as many viable listeria organisms in their spleens as mice challenged only ... | 1984 | 6202779 |
| t cell clones and their products: experimental clues for the immunoprophylaxis and immunotherapy of intracellular bacterial infections? | in this paper experimental models utilizing murine t cell clones specific for the intracellular bacterium listeria monocytogenes are described and some matters of possible relevance to the development of novel immunological strategies against intracellular bacterial infections discussed. improved vaccines against intracellular bacteria should be selected for their expression of a maximum amount of immunoprotective epitopes and their lack of immunosuppressive epitopes. analysis of these epitopes ... | 1984 | 6203841 |
| non-specific suppression of delayed-type hypersensitivity by intrathymic injection of killed bacteria. | previous intrathymic injection of 50 micrograms of killed bcg as well as killed listeria in mice produced suppression of delayed-type hypersensitivity responsiveness induced with bcg cell walls (cw) or live listeria. this finding was analysed in vitro by the macrophage migration inhibition test. non-adherent spleen cells from mice that had been injected intrathymically with killed bcg or killed listeria were tested for the ability to regulate the migration inhibition response of peritoneal exuda ... | 1984 | 6205480 |
| the significance of alpha/beta interferons and gamma interferon produced in mice infected with listeria monocytogenes. | interferon (ifn)-alpha/beta was induced in the circulation of mice infected intravenously with listeria monocytogenes 24 to 72 hr after infection, but was not induced by the administration of heat-killed listeria, listerial cell wall fraction (lcwf), or listerial soluble fraction. appearance of ifn-alpha/beta showed a pattern similar to that of the growth of bacteria in the spleen and the liver of mice. ifn-alpha/beta production was abrogated by pretreatment of mice with anti-asialo gm1 antibody ... | 1984 | 6206958 |
| effect of splenectomy on production of interferon and colony-stimulating factor in listeria monocytogenes-infected mice. | splenectomy of mice genetically susceptible to listeria monocytogenes genetically susceptible mouse strains increased their resistance to l. monocytogenes infection but had no effect on the course of infection in l. monocytogenes-resistant mice. however, splenectomy led to a dramatic decrease in the production of colony-stimulating factor and interferon after l. monocytogenes infection in all mouse strains examined. | 1984 | 6209225 |
| [analysis of protective mechanisms--relationship between activity of non-immune macrophages and immune responses (author's transl)]. | 1981 | 6210611 | |
| fate of pasteurella hemolytica in conventionally raised and germfree mice. | when pasteurella hemolytica was introduced into conventionally raised icr mice by a variety of routes (intraperitoneal, aerogenic, and oral), the inoculum was rapidly eliminated, and none of the mice died. even when the inoculum was injected intraperitoneally into sublethally irradiated (600 rads) mice, the organisms were eliminated rapidly unless suspended in 10% hog gastric mucin. when germfree icr mice were orally infected with p. hemolytica, the infection established itself in the intestinal ... | 1983 | 6218093 |
| genetic control of cell-mediated immunity in the rat. ii. sharing of either the rt1.a or rt1.b locus is sufficient for transfer of antimicrobial resistance. | the mhc restriction criteria for t cells activating macrophages in vivo and mediating antimicrobial resistance to listeria monocytogenes were determined. antimicrobial resistance could be transferred by t cells in order of decreasing efficiency from syngeneic, rt1.a compatible, rt1.b compatible and rt1 incompatible donors. alloreactive t cells responding to either a locus or b locus encoded antigens in a graft-versus-host reaction were also able to activate macrophages. approximately five times ... | 1982 | 6219163 |
| effective antibacterial protection induced by a listeria monocytogenes-specific t cell clone and its lymphokines. | the capacity of the murine listeria monocytogenes-specific t cell clone 9-36-1 and of lymphokines derived therefrom to induce antibacterial protection in vivo was studied. clone 9-36-1 was stimulated to proliferate and to produce lymphokines by in vitro culture with syngeneic accessory cells and heat-killed l. monocytogenes. although 9-36-1 cells were highly active in vitro, intravenous transfer of the cells resulted in marginal protection against a systemic infection with l. monocytogenes. in c ... | 1983 | 6220971 |
| the immune response. | 1983 | 6224323 | |
| in vitro activity of teichomycin compared with those of other antibiotics. | the glycopeptide antibiotic teichomycin had in vitro activity comparable to that of vancomycin against most gram-positive species, and it inhibited methicillin-resistant staphylococcus aureus and staphylococcus epidermidis. it was twofold more active against many s. aureus and s. epidermidis isolates than was vancomycin. teichomycin had activity comparable to that of vancomycin against listeria monocytogenes and streptococcus faecalis. it was generally more active against streptococci than was v ... | 1983 | 6227282 |