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protection of adult rabbits and monkeys from lethal shigellosis by oral immunization with a thymine-requiring and temperature-sensitive mutant of shigella flexneri y.as an approach to the development of attenuated strains, thymine-requiring (thy-) and temperature-sensitive (ts-) single and double mutants of shigella flexneri y have been isolated by u.v. mutagenesis and selection. the mutants retained the 140 mda plasmid, were sereny-negative and avirulent in 'conditioned' rabbits and in monkeys. rabbits and monkeys immunized orally with two doses of the mutants were solidly protected against disease and lethality when challenged with the homologous virulent ...19902186582
demonstration of cross-reactivity between bacterial antigens and class i human leukocyte antigens by using monoclonal antibodies to shigella flexneri.bacterial envelope proteins which share immunodeterminants with the human leukocyte antigen (hla) class i histocompatibility antigen hla-b27 may invoke spondyloarthritic disease through the process of molecular mimicry in patients expressing this phenotype. monoclonal antibodies generated by the immunization of balb/c mice with envelope proteins of shigella flexneri type 2a were tested for reactivity against cultured lymphoblastoid cell lines of defined hla phenotype. as measured by flow microfl ...19902187807
[membrane component of shigella flexneri and their relationship to bacteria antigenicity and virulence].our previous works have shown that membrane proteins of s. flexneri can elicit protection against the bacteria in vivo. in this study, we further, using human convalescent sera (hcs) from adult patients infected with s. flexneri, investigated the relationship between membrane components of s. flexneri and their antigenicities and virulences. it was shown in immunoblotting that 5 virulent strains of s. flexneri and avirulent strain t32 derived from s. flexneri 2a by istrati in romania and used as ...19902188429
increase of trimethoprim resistance among shigella species, 1975-1988: analysis of resistance mechanisms.trimethoprim (tmp) resistance among shigella species isolated from finnish travelers increased from 3.0% in 1975-1982 to 42.0%-43.8% in 1987-1988. of the 317 tmp-resistant shigella isolates identified during 1975-1988, 175 (55%) collected in 1985-1987 and in 1988 were tested further. almost all (98%) were highly resistant to tmp, suggesting a plasmid-mediated origin. the type i dihydrofolate reductase (dhfr) gene was detected in 85% of the isolates studied. twenty-three percent of the type i dhf ...19902189006
detection of shigella in feces using dna amplification.a rapid diagnostic method employing a polymerase chain reaction procedure (pcr) was used to identify shigella and enteroinvasive escherichia coli. this procedure amplified a region of the invasive-associated locus (ial) from a crude dna extract of feces. a synthetic 21-base oligonucleotide corresponding to the ial gene sequence was shown to specifically hybridize only with enteroinvasive e. coli (eiec) strains and shigella species. upon pcr amplification, a 320-base pair fragment was generated i ...19902189008
synthesis and 2d-n.m.r. analysis of a pentasaccharide glycoside of the biological repeating units of shigella flexneri variant y polysaccharide and the preparation of a synthetic antigen. 19902189552
[relations between myopia, education and intelligence]. 20002189811
differential protein expression by shigella flexneri in intracellular and extracellular environments.shigellae were intrinsically radiolabeled with [35s]methionine either extracellularly or while multiplying within infected hela cell monolayers. a complex pattern of suppression and induction of proteins was observed. proteins of approximately 97, 62, 58, 50, 25, and 18 kilodaltons (kda) were induced in shigella flexneri isolated from infected monolayers. proteins of 100, 85, 70, 64, and 55 kda were suppressed under the same conditions but were seen in cells labeled in the tissue culture medium ...19902190215
[antibiotic resistance of strains of shigella dysenteriae and flexneri isolated in tananarive and on the east coast of madagascar].from november 1988 to march 1989, stools from 804 malagasy children were examined, thirty-seven strains of shigella were isolated, from which 5 s. dysenteriae serotype 1 (= shiga bacillus) strains were found to be resistant to ampicillin, carbenicillin, streptomycin, chloramphenicol, tetracycline, sulphonamide and even to trimethoprim. resistance to trimethoprim has appeared only recently in madagascar.19902190702
laboratory tests for the diagnosis of viral disease in pregnancy. 20072190727
nutrition: prospects for the 1990s.for many decades there has been adequate information for the elimination of acute dietary deficiency diseases. scurvy, beri-beri, and pellagra, once serious scourges, are now seen only rarely. the severe forms of protein-energy malnutrition, kwashiorkor and marasmus, have also decreased greatly. nonetheless, mild to moderate forms of protein-energy deficiency, exacerbated by infection, continue to impair growth and development in a majority of the low-income pre-school age populations of most de ...19902191671
the pathology of shigella flexneri infection in rhesus monkeys: an endoscopic and histopathological study of colonic lesions.twenty-two rhesus monkeys were orally fed 1 x 10(11) live virulent shigella flexneri of either serotypes 1b, 2a, 4a or y. on the basis of colonoscopic findings they were classified into: group a - normal endoscopic picture (10 monkeys), and group b - pathological endoscopic picture (12 monkeys). pathological findings, distributed over the entire colon, were seen as either red patches (+/- erosions) or diffuse lesions, i.e. fragile red mucosa, mucosal bleeding and broad edemas. histopathological ...19902191692
[clinical significance of anti-hyaluronidase antibody]. 19902192169
[noninvasive methods for early diagnosis of chronic cor pulmonale in chronic obstructive respiratory tract diseases]. 19962192368
[inhibition of enteropathogens by clostridium butyricum miyairi 588].the inhibitory effect of clostridium butyricum miyairi 588 against various enteropathogens was investigated in mixed cultures. it was observed that c. butyricum m588 inhibited the growth of vibrio cholerae o1, v. cholerae non-o1, aeromonas hydrophila, and shigella flexneri. considering that the interaction between c. butyricum and shigella is especially important because of their proliferation site in the lower intestine, further examinations were carried out on shigella in particular. results w ...19902193065
effect of verapamil on insulin-stimulated choleresis.insulin is one of several neurohumoral substances known to have a choleretic effect in vivo and in the isolated perfused rat liver. infusion of insulin in the perfused rat liver preparation results in stimulation of bile acid-independent bile flow evidenced by increased bile flow, decreased bile acid concentration, and stable bile acid output. the mechanism of insulin-stimulated choleresis is unknown but may involve calcium as an intracellular second messenger. the present studies were performed ...19902193196
calpain and calpastatin activity in the optic pathway.the levels of the neutral proteolytic enzymes calpains and their endogenous inhibitor calpastatin were determined in the retina and in the retrobulbar optic pathway in the albino rabbit. the highest level of calpains was observed in the optic nerve with decreasing levels in the optic tract and superior colliculus. the level of calpastatin in the retina was very low compared to that in the optic nerve and tract and other parts of the nervous system.19902193255
natural sesquiterpenoids. 20002193260
[infections of the airways--when are antibiotics indicated?]. 20002193309
[urokinetography in the diagnosis and follow-up of obstructive uropathy in children].with regard to different paediatric urological diseases nuclear-medical urokinetography using the tracer 99m-tc-dtpa can identify typical functional patterns. by means of 261 investigations on 240 children, retroperistaltic waves, initial pyeloureteral and the final ureterovesical conus, dysperistaltic waves and interrupting empty strips with lacing, constrictive peristalsis can be shown in comparison with the normal anterograde "stair" pattern. moreover, ukg as a functional method makes it poss ...20012193467
[the postnatal ontogeny of gonadal endocrine function in the water vole arvicola terrestris with differing coat colors]. 20012193473
direct effect of parathyroid hormone on insulin secretion from pancreatic islets.indirect evidence indicates that parathyroid hormone (pth) interacts with pancreatic islets and modulates their insulin secretion. this property of pth has been implicated in the genesis of impaired insulin release in chronic renal failure. we examined the direct effect of pth-(1-84) and pth-(1-34) on insulin release using in vitro static incubation and dynamic perifusion of pancreatic islets from normal rats. both moieties of the hormone stimulated in a dose-dependent manner glucose-induced ins ...19902193536
partitioning of nucleoids. 19902194249
[how reliable is ultrasound fetometry?]. 20002195807
extra-anatomic bypass for treatment of leg ischemia. 20002195833
an estimation of dental treatment needs in two groups of refugees in sweden.the aim of this study was to estimate dental treatment need in groups of chilean and polish refugees in sweden. of the nordic countries, sweden accepts the greatest number of refugees. an average of 5000 refugees arrived annually in 1981-85, increasing to 15,000 during 1986-87. refugees and their families now comprise 93% of non-nordic immigration. in 1981-83 a sample of 193 chilean and 92 polish refugees in the county of stockholm was selected for this study. dental treatment needs were calcula ...20002195841
serum and tissue cage fluid concentrations of ciprofloxacin after oral administration of the drug to healthy dogs.ciprofloxacin, a fluoroquinolone antimicrobial agent, was administered orally to 4 healthy dogs at dosage of approximately 11 and 23 mg/kg of body weight, every 12 hours for 4 days, with a 4-week interval between dosing regimens. serum and tissue cage fluid (tcf) concentrations of ciprofloxacin were measured after the first and seventh dose of each dosing regimen. the peak concentration was greatest in the serum after multiple doses of 23 mg/kg (mean +/- sem; 5.68 +/- 0.54 micrograms/ml) and lea ...19902195927
increased activity of digoxin-like substance in low-renin hypertension in acromegaly.arterial hypertension is common in acromegaly, but the pathogenesis of this complication remains unknown. to determine the role of an endogenous na,k pump inhibitor/digoxin-like substance (dls) in the pathogenesis of hypertension in acromegaly 76 subjects: 28 with acromegaly, 20 with essential hypertension and 28 healthy controls were studied. serum dls was measured with the use of radioimmunoassay and bioassay by the inhibition of digoxin-sensitive erythrocyte 86-rb uptake. in acromegaly, the a ...19972196126
rational treatment of acid-base disorders.acid-base derangements are encountered frequently in clinical practice and many have life-threatening implications. treatment is dependent on correctly identifying the acid-base disorder and, whenever possible, repairing the underlying causal process. bicarbonate is the agent of choice for the treatment of acute metabolic acidosis. controversy surrounds the use of alkali therapy in lactic acidosis and diabetic ketoacidosis, but bicarbonate should clearly be administered for severe acidosis. in m ...19972196165
inactivation of legionella pneumophila by monochloramine.chloramination which is used in south australia to control the growth of naegleria fowleri, was investigated to see if it would also control that of legionella pneumophila. it was found that l. pneumophila was more sensitive than escherichia coli to monochloramine. at 1.0 mg/l, a 99% kill of l. pneumophila was achieved in 15 min compared with 37 min for a 99% kill of e. coli. combined with the stability of monochloramine, even at elevated temperatures, the results suggest that this disinfectant ...19902196255
aluminum, a neurotoxin which affects diverse metabolic reactions.experimental evidence is summarized to support the hypothesis that chronic exposure to low levels of aluminum may lead to neurological disorders. these disorders result from defective phosphorylation--dephosphorylation reactions, reduced glucose utilization and site-specific damage inflicted by free radicals produced by altered iron metabolism. the brain is a highly compartmentalized organ. therefore, a co-localization of critical mass of metabolic errors rather than a single event may be essent ...19902198876
[complexes of phorbol tumor promoters with protein kinase c].based on the literature data, a systematic comparison of relationships between the structures of incomplete and complete phorbol tumor promoters, diacylglycerols and their activities in various biological test-systems was carried out. the specific features of the phorbol esters-protein kinase c complexes responsible for the induction of the first and second stages of the tumor promotion in mouse skin, were established. the type of diacylglycerol binding to protein kinase c which confers to the l ...19902198948
abc of major trauma. management of hypovolaemic shock. 19972198971
from inkblots to art therapy. 19952199910
polymerase chain reaction for detection of invasive shigella flexneri in food.the polymerase chain reaction (pcr) was used to amplify a 760-base-pair (bp) fragment with the 220-kbp invasive plasmids of enteroinvasive escherichia coli, shigella flexneri, shigella dysenteriae, shigella boydii, and shigella sonnei as templates. this pcr product was easily detected by agarose gel electrophoresis. a 210-bp acci-psti fragment lying within the amplified region was used as a probe in southern hybridization blots and showed that the pcr-generated product was derived from the invas ...19902200336
raising high density lipoprotein cholesterol. the biochemical pharmacology of reverse cholesterol transport. 19962200405
epidemiology of shigellosis in teknaf, a coastal area of bangladesh: a 10-year survey.the epidemiological data on shigellosis in teknaf, a coastal area of bangladesh, were reviewed for a 10-year period (1975-84). certain similarities and differences were observed in the epidemiology of the disease in teknaf when compared with urban dhaka and rural matlab. similarities included: round-the-year infection with two peaks, one in the monsoon period and the other in the winter period; high male to female attendance ratio at the treatment centre; the predominance of infection in the und ...19902200700
molecular epidemiology of shigella infection in central australia.shigellosis is endemic in central australia and the infections are predominantly due to shigella flexneri 6, shigella flexneri 2a and shigella sonnei. plasmid profiles of isolates collected from 1985-9, suggested that infections caused by shigella flexneri 6 were predominantly due to a single clone, whereas those caused by shigella flexneri 2a and shigella sonnei were due to several genetically diverse strains, although strains with identical plasmid profiles were found in widely separated geogr ...19902200701
plasmid profile analysis and antimicrobial susceptibility patterns of shigella isolates from nigeria.in an epidemiological survey, plasmid profiles and antimicrobial susceptibility testing of 100 shigella isolates in lagos, nigeria was done. all the isolates were sensitive to nalidixic acid, nitrofurantoin and ciprofloxacin. the commonest antimicrobial susceptibility pattern was resistance to ampicillin, colistin sulphate, co-trimoxazole, streptomycin and tetracycline. all but 4 of 100 isolates screened contained one or more plasmids. plasmid profile analysis distinguished more strains than did ...19902200702
[the formulation of epidemiological hypotheses by using the methods of multivariate statistical analysis].the work demonstrates the main approaches to the use of the methods of multidimensional analysis for the creation of a hypothesis on the mechanism of the epidemiological process of dysentery in organized groups. the main risk factors have been established, and their role in the formation of annual, all-the-year-round and seasonal dysentery morbidity has been quantitatively evaluated. the results of analysis show the existence of diverse variants of the alimentary route of the transmission of inf ...19902201148
[morphological changes caused by the dermonecrosis factor of the causative agents of cholera and various other intestinal infections].intra- or subepithelial focal purulent inflammation with necrosis of exudating leucocytes during 1-2 days is developed in consequence of intradermal injection of the living cholera vibrios, cultured on membrane agar, or their supernatants. sometimes coagulative necrosis of cover epithelium arises without preliminary purulent inflammation stage from the very beginning. intradermal injection of living cholera vibrios leads to the development of coagulative necrotic foci in derma too. the vascular ...19902201411
childhood shigellosis: clinical and bacteriological study.ninety-three children with shigellosis were hospitalized in a regional hospital in kuwait during the year 1988. s. flexneri was the most common isolate (54%) followed by s. sonnei (39%) and s. boydii (7%). in addition to the gastrointestinal manifestations, 14 patients (15%) developed generalized convulsions. the benign and self-limiting nature of the convulsions associated with shigellosis means that neither diagnostic procedure nor drug therapy are usually necessary. the disease was self-limit ...19902202839
positive immunostaining of ovine congenital progressive muscular dystrophy with antibody against n- and c-terminal dystrophin. 19902203334
[complete denture with liquid cushion]. 20082203631
the evaluation of the abdominal aorta: a "how-to" for cardiac sonographers.a thorough evaluation of the abdominal aorta can be readily achieved by use of the standard views of the echocardiographic examination. the ultrasound evaluation of the abdominal aorta represents a logical extension of the standard echocardiographic examination of the adult patient. this article provides the information needed to carry out a complete ultrasound examination of the abdominal aorta including the anatomy, the vascular disease, and the steps involved in accomplishing the ultrasound e ...20082206553
[internal tooth resorption]. 20072206646
synthesis and biological activity of 3-vinylthio- and 3-vinylthiomethylcephem derivatives.the synthesis and biological properties of some 3-vinylthio- and 3-vinylthiomethylcephem derivatives are described. both series possess potent antibacterial activity. among them, 3-[(z)-2-cyanovinylthiomethyl]cephem derivative was found to have an expanded antibacterial spectrum.20082211378
mutational analysis of the virg protein, a transcriptional activator of agrobacterium tumefaciens virulence genes.the virg protein of agrobacterium tumefaciens is required in conjunction with the vira protein for transcriptional activation of the virulence (vir) genes in response to plant phenolic compounds. these proteins are members of a family of two component regulatory systems. vir genes are activated via a cascade of phosphorylation reactions involving a specific aspartic acid residue of the virg protein. we have conducted a mutational analysis of the virg protein. by mutating conserved and nonconserv ...19902211523
reversal of fluoxetine-induced anorgasmia by cyproheptadine in two patients.the authors report two cases of ejaculatory dysfunction induced by fluoxetine. cyproheptadine, an antihistaminic and antiserotonergic drug, restored sexual function in each case. possible mechanisms of fluoxetine-induced anorgasmia are presented and treatment options are reviewed.20082211550
depression and organic mood disorder. 20082211553
free amino acid turnover in methanogens measured by 15n nmr spectroscopy.turnover of the nitrogen moiety from free amino acid pools in two thermophilic methanogens, methanobacterium thermautotrophicum delta h and methanococcus thermolithotrophicus sn1, has been monitored with 15n nmr spectroscopy. in cells growing exponentially on 15nh4cl, glutamate was the major soluble 15n-labeled species in both organisms. when the mb. thermoautotrophicum cells were harvested, washed, and resuspended into medium containing 14nh4cl, the resonance for [15n]glutamate decreased with a ...19902211697
effects of thrombospondin antibody on the recovery of endothelial cells from hyperthermia.in addition to the increased synthesis of the classical heat-shock proteins (28,000, 71,000, 73,000, 90,000 and 100,000 mr polypeptides) there is also an increase of thrombospondin in the growth medium of endothelial cells exposed to hyperthermia. the effect of a monoclonal antibody to thrombospondin on the recovery of endothelial cells from hyperthermia as it relates to cytoskeletal organization and cell spreading was assessed. the antibody interacts with the heparin-binding domain of thrombosp ...19902211867
determination of dexamethasone in bovine tissues by coupled-column normal-phase high-performance liquid chromatography and capillary gas chromatography-mass spectrometry.a new method for the determination of dexamethasone in bovine liver and muscle tissues has been developed. crude tissue extracts were obtained by means of a three-phase liquid-liquid extraction scheme. the resulting residue was subjected to coupled-column normal-phase high-performance liquid chromatography which served to isolate the drug for the purpose of screening and quantification. sample was injected onto the first column of the system, a phenyl column, from which a heart-cut was diverted ...19902211922
autoantibodies to the hla-b27 sequence cross-react with the hypothetical peptide from the arthritis-associated shigella plasmid.we previously reported elevated serum antibody levels to a peptide representing the hla-b27 polymorphic region (b27 peptide) in hla-b27(+) ankylosing spondylitis (as) patients. a plasmid (phs-2) isolated from arthritogenic shigella flexneri strains had been shown to encode an amino acid sequence homologous to hla-b27. rabbit antibody to this sequence (phs-2 peptide) strongly cross-reacted with b27 peptide and, to a much lesser extent, with klebsiella nitrogenase peptide. serum antibody levels to ...19902212008
treatment of hirsutism with the pure antiandrogen flutamide.the effectiveness of the antiandrogen flutamide in combination with an oral contraceptive was studied in 20 patients with moderate to severe hirsutism. eight patients had no previous therapy, whereas 12 had failed to respond to oral contraceptives, spironolactone, or dexamethasone therapy. treatment with the antiandrogen flutamide (250 mg twice daily) and an oral contraceptive (ortho 1/35) resulted in a particularly rapid and marked decrease in the total hirsutism score, which reached the normal ...19982212145
echocardiographic definition of the left ventricular centroid. ii. determination of the optimal centroid during systole in normal and infarcted hearts.although two-dimensional echocardiography is widely used in both clinical and experimental evaluations of regional cardiac wall motion, there is no established clinical method for quantitative analysis of the wall motion, not even for the normal radial motion observed in short-axis images. measurement of radial wall motion requires determination of a centroid from which the radii emanate. depending on its definition, the centroid is variously affected throughout systole by cardiac translation, r ...19902212382
recollections of pioneers in nutrition: from starvation to cholesterol. 19982212384
the role of chemosensitive muscle receptors in cardiorespiratory regulation during exercise.several possible mechanisms leading to the cardiorespiratory adjustments to muscular exercise can be considered. activation of the cardiovascular and respiratory centers may result from: (1) direct or reflex action of circulating metabolites (humoral control); (2) cortical influxes (central drive); (3) nervous impulses from receptors in the contracting muscles (peripheral drive). information presently available focuses most of the interest upon the muscular drive. our studies on anesthetized ani ...19902212481
protective effect of pgd2 against ethanol-induced gastric mucosal injury in rats.the protective effect of prostaglandin d2 (pgd2) in ethanol-, hcl-, or nacl-induced gastric mucosal injury was investigated. to clarify the mechanism, the gastric mucosal hemodynamics were also investigated using reflectance spectrophotometry and laser doppler flowmetry in anesthetized rats. pgd2 administered orally significantly reduced the ethanol-induced mucosal injury. although it did not reach any significance, pgd2 also reduced 0.6 n hcl-induced mucosal damage, and slightly reduced 25% nac ...19902212542
anion-coupled na efflux mediated by the human red blood cell na/k pump.the red cell na/k pump is known to continue to extrude na when both na and k are removed from the external medium. because this ouabain-sensitive flux occurs in the absence of an exchangeable cation, it is referred to as uncoupled na efflux. this flux is also known to be inhibited by 5 mm nao but to a lesser extent than that inhibitable by ouabain. uncoupled na efflux via the na/k pump therefore can be divided into a nao-sensitive and nao-insensitive component. we used dids-treated, so4-equilibr ...19902212979
[metabolic activation of carcinogenic n-nitrosodialkylamines].chemical and biological properties of metabolically activated species of carcinogenic n-nitrosodialkylamines are reviewed. alpha-hydroxy nitrosamines and their derivatives; alpha-acetoxy nitrosamines, alpha-hydroperoxy nitrosamines, alpha-phosphonooxy nitrosamines and alkanediazotates are included. metabolic deactivation through denitrosation and metabolic activation through beta-oxidation are also mentioned.20002213524
[studies on resistant mechanisms in the resistant bacteria to chlorhexidine. ii. chemical components of the cell membrane and the electron microscopical observation of cell surface structure of chlorhexidine-resistant bacteria].the mechanisms of resistance of serratia marcescens and pseudomonas cepacia to chlorhexidine were studied. leakage of the cellular component such as protein was observed in a chlorhexidine sensitive strain (s1) of s. marcescens when s1 was treated with chlorhexidine at 40 micrograms/ml concentration, while this phenomenon was not observed in a resistant strain (r1). the following observations were made concerning about cell surface structure in the chlorhexidine sensitive and resistant strains o ...19902213528
new animal breeding techniques and their application.the new biotechnologies of gene transfer, in-vitro production, cloning and sexing of embryos have been developed and are being refined with efficiencies suitable for use in animal agriculture. efficient in-vitro systems for maturing oocytes and capacitating spermatozoa, for fertilizing and developing the embryos have resulted in commercial in-vitro production of embryos. cloning of embryos by nuclear transfer has been accomplished for sheep, cattle, pigs and rabbits with nuclear material supplie ...19902213713
plants used in guatemala for the treatment of gastrointestinal disorders. 1. screening of 84 plants against enterobacteria.gastrointestinal disorders are important causes of morbidity in developing countries. natural healing is the traditional way of treating these diseases in guatemala. ethnobotanical surveys and literature reviews showed that 385 plants from 95 families are used in guatemala for the treatment of gastrointestinal disorders. the activity of 84 of the most commonly used plants was screened in vitro against five enterobacteria pathogenic to man (enteropathogenic escherichia coli, salmonella enteritidi ...19902214824
[influence of static flow (creep) on amalgam hardness. effect of alloys and measured areas].the authors studied the creep of 5 amalgam alloys (1 conventional and 4 with high cooper) by the application os static load of 36 mpa in 478 mm specimens, 7 days old. after creep test, the samples were included in acrylic resin and vickers hardness determined by three penetrations for each portion (cervical, medium and occlusal). samples not submitted to the creep test was used with control. they concluded that no statistic difference was found in creep test but in vickers test all the studied m ...19582218050
a pure class ii mhc disparity does not induce rejection of cornea or heart grafts in the rat. 19902219343
[the lymphocyte transformation test in sarcoidosis].a suppressive effect of the sarcoidosis serum on the mitogenic stimulation of lymphocytes could be confirmed statistically (p less than 1%). but there remained a lot of deviating results in distinct individual cases which could not be explained by subdividing the material in regard to different clinical points of view. the practical utility of the ltt as a diagnostic tool in sarcoidosis is therefore very limited. the partly missing suppression or even a stimulation compared to the culture with p ...20072219991
[the article by iu. p. solodovnikov the etiological structure of bacterial dysentery in the ussr]. 19902220214
[lung cancer in women in moscow (epidemiology, etiology and surgical treatment)].in the studied period (1973-1987) the lung carcinoma morbidity rate among females of moscow, in general intensive indices (per 100,000 females), showed a tendency to reduce (18.4 in 1973 and 15.1 in 1987). a reverse tendency is mostly encountered in other countries. more than half of patients with lung carcinoma were over 70 years of age. the ratio of males with lung carcinoma to that of females grew from 3.0:1.0 in 1973-1977 to 3.6:1.0 in 1983-1987. in the period from 1979 to 1988, 380 females ...20072223213
[lung cancer in women in moscow (epidemiology, etiology and surgical treatment)].in the studied period (1973-1987) the lung carcinoma morbidity rate among females of moscow, in general intensive indices (per 100,000 females), showed a tendency to reduce (18.4 in 1973 and 15.1 in 1987). a reverse tendency is mostly encountered in other countries. more than half of patients with lung carcinoma were over 70 years of age. the ratio of males with lung carcinoma to that of females grew from 3.0:1.0 in 1973-1977 to 3.6:1.0 in 1983-1987. in the period from 1979 to 1988, 380 females ...20072223213
parathyroid gland disease and hypercalcemia. 20072223448
parathyroid gland disease and hypercalcemia. 20072223448
fluorosis, osteopetrosis, and ectopic calcification. 20072223455
fluorosis, osteopetrosis, and ectopic calcification. 20072223455
buerger's disease and inflammatory aspects of atherosclerosis. 20072223460
buerger's disease and inflammatory aspects of atherosclerosis. 20072223460
benign tumors of bone. 20072223464
benign tumors of bone. 20072223464
surveillance of tetanus, 1987 and 1988. 20072223560
surveillance of tetanus, 1987 and 1988. 20072223560
intrathecal administration of 131i radiolabelled monoclonal antibody as a treatment for neoplastic meningitis.fifteen patients with neoplastic meningitis received a single intrathecal injection of between 11 and 60 mci of a 131i radiolabelled monoclonal antibody (moab), chosen for its immunoreactivity to tumour. major toxicity was manifest as nausea, vomiting and headache (7/15 patients), reversible bone marrow suppression (3/8 patients) and seizures (2/15 patients). nine patients were evaluable for either a tumour or clinical response. six of these demonstrated an event-free response that was maintaine ...20072223581
intrathecal administration of 131i radiolabelled monoclonal antibody as a treatment for neoplastic meningitis.fifteen patients with neoplastic meningitis received a single intrathecal injection of between 11 and 60 mci of a 131i radiolabelled monoclonal antibody (moab), chosen for its immunoreactivity to tumour. major toxicity was manifest as nausea, vomiting and headache (7/15 patients), reversible bone marrow suppression (3/8 patients) and seizures (2/15 patients). nine patients were evaluable for either a tumour or clinical response. six of these demonstrated an event-free response that was maintaine ...20072223581
regression of diffuse osteosclerosis in hairy cell leukaemia after treatment with interferon. 20072223637
regression of diffuse osteosclerosis in hairy cell leukaemia after treatment with interferon. 20072223637
the continuous decrease in the number of sspe annual cases ten years after compulsory anti-measles immunization.the record of sspe cases diagnosed immunochemically and serologically in our laboratory, standing for about 60% of the total new cases reported in our country, shows a significant decrease in the incidence in 1988-89 (from 5.21 new cases per year per million total population in 1987 to 1.82 cases in 1988). in 85% of the patients, sspe onset occurred at the age of 10 years or more, suggesting the possibility of a primary measles infection before anti-measles immunization became compulsory. high s ...19902223653
the continuous decrease in the number of sspe annual cases ten years after compulsory anti-measles immunization.the record of sspe cases diagnosed immunochemically and serologically in our laboratory, standing for about 60% of the total new cases reported in our country, shows a significant decrease in the incidence in 1988-89 (from 5.21 new cases per year per million total population in 1987 to 1.82 cases in 1988). in 85% of the patients, sspe onset occurred at the age of 10 years or more, suggesting the possibility of a primary measles infection before anti-measles immunization became compulsory. high s ...19902223653
mortality of a cohort of tin miners 1941-86.the mortality patterns of united kingdom tin miners were examined in relation to calendar period and duration of underground work with particular attention to lung cancer and exposure to radon. subjects were all men who had worked for at least one year between 1941 and 1984 at one of two united kingdom tin mines and for whom a complete work history could be constructed from mine records. standardised mortality ratios (smrs) were calculated using national (england and wales) rates. the pattern of ...20072223659
mortality of a cohort of tin miners 1941-86.the mortality patterns of united kingdom tin miners were examined in relation to calendar period and duration of underground work with particular attention to lung cancer and exposure to radon. subjects were all men who had worked for at least one year between 1941 and 1984 at one of two united kingdom tin mines and for whom a complete work history could be constructed from mine records. standardised mortality ratios (smrs) were calculated using national (england and wales) rates. the pattern of ...20072223659
age, sex, and region adjusted concentrations of chromium and nickel in lung tissue.chromium (cr) and nickel (ni) concentrations were measured in lung tissue from 110 random necropsies by means of atomic absorption spectrometry. the subjects originated from the ruhr district (bochum (71 cases) and dortmund (16 cases) areas), which has been defined as a particular pollution area with locally high cr and ni emissions, and from münster and vicinity (23 cases). the cr and ni concentrations in lung tissue of the subjects from the ruhr district (3.09 (sd 2.99) micrograms cr/g, 0.65 ( ...20072223660
age, sex, and region adjusted concentrations of chromium and nickel in lung tissue.chromium (cr) and nickel (ni) concentrations were measured in lung tissue from 110 random necropsies by means of atomic absorption spectrometry. the subjects originated from the ruhr district (bochum (71 cases) and dortmund (16 cases) areas), which has been defined as a particular pollution area with locally high cr and ni emissions, and from münster and vicinity (23 cases). the cr and ni concentrations in lung tissue of the subjects from the ruhr district (3.09 (sd 2.99) micrograms cr/g, 0.65 ( ...20072223660
fetal macrosomia in potential diabetics with normal oral glucose tolerance: a case control study. 20072223691
fetal macrosomia in potential diabetics with normal oral glucose tolerance: a case control study. 20072223691
[the intradermal tuberculin test and the kveim-siltzbach test in sarcoidosis]. 20072223733
[the intradermal tuberculin test and the kveim-siltzbach test in sarcoidosis]. 20072223733
differential scanning calorimetry study of mixed-chain phosphatidylcholines with a common molecular weight identical with diheptadecanoylphosphatidylcholine.to examine the thermotropic phase behavior of various mixed-chain phosphatidylcholines in excess water and to compare it with the known behavior of identical-chain phosphatidylcholines, we have carried out high-resolution differential scanning calorimetric (dsc) studies on aqueous dispersions of 10 different mixed-chain phosphatidylcholines. these lipids, c(16):c(18)pc, c(18):c(16)pc, c(15):c(19)pc, c(19):c(15)pc, c(14):c(20)pc, c(20):c(14)pc, c(13):c(21)pc, c(21):c(13)pc, c(12):c(22)pc, and c(2 ...20072223759
differential scanning calorimetry study of mixed-chain phosphatidylcholines with a common molecular weight identical with diheptadecanoylphosphatidylcholine.to examine the thermotropic phase behavior of various mixed-chain phosphatidylcholines in excess water and to compare it with the known behavior of identical-chain phosphatidylcholines, we have carried out high-resolution differential scanning calorimetric (dsc) studies on aqueous dispersions of 10 different mixed-chain phosphatidylcholines. these lipids, c(16):c(18)pc, c(18):c(16)pc, c(15):c(19)pc, c(19):c(15)pc, c(14):c(20)pc, c(20):c(14)pc, c(13):c(21)pc, c(21):c(13)pc, c(12):c(22)pc, and c(2 ...20072223759
thermodynamic properties of globular proteins and the principle of stabilization of their native structure.a semi-empirical method has been used to estimate the thermodynamic parameters of hydration of buried surface areas of ribonuclease s, lysozyme and myoglobin from the model of complete unfolding according to ooi et al. ((1987) proc. natl. acad. sci. usa 84, 3086-3090). the buried surface area of proteins is considered as the difference between the accessible surface area of native protein and the completely extended polypeptide chain according to lee and richards ((1971) j. mol. biol. 55, 379-40 ...20082223840
[detection of protease specifically splitting actin in revertants of shigella flexneri l-forms].proteolytic activity of cell extracts from revertants of shigella flexneri l-forms as well as biochemical properties of these strains and their sensitivity to antibiotics were studied. the protease found earlier in cells of strain e. coli a2 was shown to be synthesized by one of 8 revertants under study. this protease split actin and did not split some other proteins, its activity was inhibited by inhibitors of metalloproteases. strain 5a2c which produced the protease was similar to the strain e ...19902224099
a randomized comparison of manipulation of the fractured nose under local and general anaesthesia.reduction of simple nasal fractures may be performed under local or general anaesthesia: the latter is by far the most popular method in britain, though why is hard to define. we have attempted to compare the 2 approaches by means of a randomized, prospective trial. fifty consecutive, adult patients with radiologically proved fractures of the nasal bones were randomized to a local or general anaesthesia group and underwent manipulation with asch's and walsham's forceps between 7 and 15 days post ...20082225504
[cloning of shigella flexneri 2a genes coding for restriction- modification system sfl2ai].the sfl2ai system of restriction-modification (rm) was revealed in the cells of shigella flexneri encoded by pkmr114 plasmid belonging to the incn incompatibility group. the genes for sfl2ai rm system were cloned. the system was ascribed to the enzymes of the ecorii specificity, as shown by in vivo and in vitro experiments. restriction analysis of these genes' region and antigenic properties of the sfl2ai endonuclease pointed to significant differences between this and ecorii rm systems.19902227395
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