Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| a 1-h topical therapy for the treatment of helicobacter pylori infection. | a novel topical therapeutic methodology for the treatment of helicobacter pylori infection was developed and studied in 25 patients with h. pylori to evaluate safety and efficacy. | 1995 | 7801950 |
| helicobacter pylori infection does not increase gastric antrum mucosal cell proliferation. | gastric carcinoma is the world's second most common cancer. recent studies suggest an association between helicobacter pylori and gastric carcinoma. the aim of this study was to address the effects of h. pylori infection on gastric antrum mucosal cell proliferation. | 1995 | 7801951 |
| nonulcer dyspepsia in a dutch working population and helicobacter pylori. ulcer history as an explanation of an apparent association. | there is considerable debate about whether helicobacter pylori infection is important in causing nonulcer dyspepsia. many studies assessing this relationship have been performed in selected patient populations and included patients with a history of peptic ulcer. general population-based data with attention to ulcer history are needed to clarify this relationship. | 1995 | 7802524 |
| serology as a valid screening test for helicobacter pylori infection in asymptomatic subjects. | serologic testing is generally accepted as a valid noninvasive screening method for the detection of a helicobacter pylori infection. to validate serology as an appropriate screening test for h pylori infection in symptom-free subjects, a recent-generation enzyme-linked immunosorbent assay for the detection of h pylori-specific igg was performed in a large series of asymptomatic women. blood samples for h pylori serology were taken from 542 apparently healthy women (aged 20 to 40 years) during p ... | 1995 | 7802549 |
| salivary antibodies to helicobacter pylori: screening dyspeptic patients before endoscopy. | diagnostic tests on saliva have advantages compared with those on serum. in 119 consecutive dyspeptic patients referred for endoscopy we developed and validated an enzyme-linked immunosorbent assay to detect salivary immunoglobulins to helicobacter pylori. salivary igg distinguished positive and negative cases (p < 0.0001), but salivary iga did not. the optimum performance of salivary igg (85%) was similar to that of serum igg (90%) and better than that of salivary iga. using our assay and a his ... | 1994 | 7802777 |
| salivary antibodies to helicobacter pylori: screening dyspeptic patients before endoscopy. | 1994 | 7802823 | |
| no cultural detection of helicobacter pylori in dental plaque. | helicobacter pylori causes human type b gastritis and is involved in the etiology of peptic ulcer disease. the routes of transmission of h. pylori are still unclear. the microorganism may be transmitted orally, since h. pylori has been detected in dental plaques. to confirm the hypothesis that dental plaques are a reservoir of h. pylori, 100 dental plaque specimens from 55 dental surgery patients were incubated on one nonselective and up to four selective agar media for the detection of h. pylor ... | 1994 | 7803925 |
| helicobacter pylori bacteraemia. | 1994 | 7805696 | |
| expression of interleukin 8 and cd54 by human gastric epithelium after helicobacter pylori infection in vitro. | helicobacter pylori is associated with neutrophil infiltrates, although the mechanism of their recruitment is only partially defined. the aim of the study was to determine if kato iii, a human gastric epithelial cell line, expressed cytokines and the intercellular adhesion molecule 1 (icam-1), which could contribute to the initiation of inflammation during infection with h. pylori. | 1995 | 7806065 |
| adaptive mutation and cocolonization during helicobacter pylori infection of gnotobiotic piglets. | clinical isolates of helicobacter pylori, the gastric pathogen implicated in gastritis, peptic ulcers, and gastric cancer in humans, are diverse in traits likely to be important for colonization and disease. here we report studies using a gnotobiotic piglet-h. pylori infection model to test for host-specific adaptation and to detect cocolonization by different strains. first, an h. pylori strain that initially had grown only weakly in piglets was adapted to them by spontaneous mutation and selec ... | 1995 | 7806346 |
| analysis of expression of caga and vaca virulence factors in 43 strains of helicobacter pylori reveals that clinical isolates can be divided into two major types and that caga is not necessary for expression of the vacuolating cytotoxin. | colonization of the mucosa of the stomach and the duodenum by helicobacter pylori is the major cause of acute and chronic gastroduodenal pathologies in humans. duodenal ulcer formation strongly correlates with the expression of an antigen (caga) that is usually coeexpressed with the vacuolating cytotoxin (vaca), a protein that causes ulceration in the stomach of mice. however, the relationship between these two virulence factors is unknown. to define whether caga and vaca are coexpressed in all ... | 1995 | 7806390 |
| observations on gastric histology, endoscopy appearance and helicobacter pylori after corrective surgery for bile reflux gastritis. | this study was designed to look for the presence of campylobacter pylori in patients who had roux-en-y procedure to control symptoms of severe alkaline reflux gastritis (arg) and to correlate findings with endoscopy and histology. twenty five patients, who had been operated on for arg during the last 15 years, were recruited into this study (mean age: 53 years). surgical procedures were performed by a single surgeon (k.b.). clinical symptoms of arg improved after corrective surgery in all cases, ... | 1994 | 7808042 |
| summary of the nih consensus. helicobacter pylori in peptic ulcer disease. | 1994 | 7808195 | |
| [high incidence of helicobacter pylori infections in an endoscopic pediatric patient series]. | we evaluated in children with abdominal complaints the prevalence of helicobacter pylori gastric and duodenal colonization and the histological features of gastric and duodenal mucosae. fifty patients, aged 1-17 years, underwent upper endoscopy for recurrent abdominal pain, vomiting and/or gastrointestinal bleeding. with serological, bacteriological and/or histological methods twenty-eight children were demonstrated to be helicobacter pylori-positive. no statistically significant differences wer ... | 1994 | 7808363 |
| absence of helicobacter pylori in subgingival samples determined by polymerase chain reaction. | the polymerase chain reaction was used for the detection of helicobacter pylori from subgingival plaque in 336 periodontitis patients. a pair of primers derived from the h. pylori urease gene a served to amplify a targeted 411-bp fragment of genomic dna. this technique permitted the detection of as few as 60 h. pylori cells. paper point samples from 3 deep periodontal pockets per patient were immersed in 1 ml of phosphate-buffered saline or distilled water, dna was solubilized by detergent/prote ... | 1994 | 7808777 |
| helicobacter pylori and chronic gastritis: anatomico-functional correlations. | 1994 | 7812032 | |
| association of alcohol consumption and helicobacter pylori infection in young adulthood and early middle age among patients with gastric complaints. a case-control study on finnish conscripts, officers and other military personnel. | there is growing evidence that helicobacter pylori is responsible for a variety of gastric and duodenal changes which can eventually lead to stomach cancer. little is known about risk factors for h. pylori infection. we re-analyzed the association of alcohol with h. pylori positivity in 451 conscripts, officers and other military personnel endoscoped due to gastric complaints in the central military hospital of finland in 1987 and 1988. serology and culture were done in all patients. alcohol con ... | 1994 | 7813699 |
| helicobacter pylori infection and gastritis in healthy nigerians. | in a study of forty asymptomatic volunteers from northern nigeria; 35 (87.5%) had histological gastritis and 32 (80%) were infected by helicobacter pylori. all but one of the patients infected by helicobacter pylori had histological gastritis. this high prevalence of h. pylori infection in young, asymptomatic subjects, occurs in an area with a low prevalence of duodenal ulcer. the possible reasons for this are discussed. | 1994 | 7813703 |
| prospective evaluation of upper gastrointestinal mucosal lesions in children with ulcerative colitis and crohn's disease. | eighty-eight consecutive children with inflammatory bowel disease were studied, and upper gastrointestinal endoscopy was performed in 80 of them as one of the initial investigations before commencing medical or nutritional treatment. forty-one children were found to have crohn's disease and 47, ulcerative colitis. upper gastrointestinal endoscopy revealed pathology in 32 (80%) cases of crohn's disease, esophagitis in 16, and esophageal ulcer in two, nonspecific gastritis in 22, duodenitis or duo ... | 1994 | 7815240 |
| is interstitial cystitis an infectious disease? | interstitial cystitis (ic) is manifest by years of urinary frequency, urgency, and bladder pain and on cystoscopy, is diagnosed by petechial hemorrhages or ulcers. the etiology is unknown; the prominent theories are that ic is an autoimmune disease or is linked to increased permeability of the bladder mucosa. although sought, no infectious agent has ever been identified. the disease has many characteristics of a chronic infection and the author's opinion is that an infectious disease has not bee ... | 1994 | 7815976 |
| helicobacter pylori in patients undergoing upper endoscopy in jamaica. | one hundred and two consecutive patients undergoing upper gastrointestinal endoscopy were tested for h. pylori by a rapid urease test, using antral biopsy specimens. there were 60 men (mean age 54 yrs) and 42 women (mean age 49 yrs). fifty-six patients (55%) were positive for h. pylori. of male patients, 36 (60%) and of female patients, 20 (48%) tested positive. sixty-eight per cent of patients with antral gastritis, 65% with duodenal ulcer and 60% with gastric ulcer had h. pylori. thirty-nine p ... | 1994 | 7817542 |
| helicobacter pylori in patients with systemic sclerosis: detection with the 13c-urea breath test and eradication. | in patients with systemic sclerosis peristaltic abnormalities may delay gastric emptying, giving rise to bacterial overgrowth, including possibly helicobacter pylori (hp). infection with helicobacter is an important risk factor for esophageal and gastric diseases, including esophagitis, gastritis and gastric cancer. the purpose of this prospective study was to assess gastric hp infection in patients with systemic sclerosis. in 12 patients with systemic sclerosis the newly introduced breath test ... | 1994 | 7817672 |
| serum gastrin, pepsinogens, parietal cell and helicobacter pylori antibodies in patients with gastric polyps. | to determine serum concentration of gastrin and pepsinogens (pgs) as markers for the gastric mucosal status and to elucidate the prevalence of serum helicobacter pylori (h pylori) igg antibodies and parietal cell autoantibodies (pcas) in patients with gastric polyps. | 1994 | 7817697 |
| [chronic gastritis associated with helicobacter pylori in children]. | 1994 | 7818732 | |
| eradication of helicobacter pylori should be pivotal in managing peptic ulceration. eradication largely prevents relapse. | 1994 | 7819903 | |
| eradication of helicobacter pylori should be pivotal in managing peptic ulceration. helicobacter pylori is not the causative agent. | 1994 | 7819904 | |
| helicobacter pylori: the new bug on the (paraffin) block. | a nameless spirillar organism in search of a disease only a few years ago, helicobacter pylori has seen its fortunes suddenly reversed. after a rapid succession of name changes and some acrimonious disputes across continents, in less than a decade h. pylori has been catapulted to the centre stage of gastroenterological and microbiological research and has topped the most-wanted list of the pharmaceutical industry. the discovery of h. pylori has provided the momentum for the formation of the grou ... | 1994 | 7820298 |
| helicobacter pylori: after ten years, still an enigma. | 1994 | 7820889 | |
| determination of helicobacter pylori status by reverse transcription-polymerase chain reaction. comparison with urea breath test. | we previously reported the development and the possible application of reverse transcription-polymerase chain reaction (rt-pcr) assay for the detection of h. pylori in gastric mucosal biopsy specimens. in this communication, the application of this assay was assessed by comparing its results from 79 gastric biopsy specimens obtained from 68 patients with the more traditional [13c]urea breath test. when the amplified products were examined, the specificity and sensitivity of this rt-pcr assay wer ... | 1995 | 7821096 |
| long-term prospective study of helicobacter pylori in nonulcer dyspepsia. | helicobacter pylori is present in up to 87% of patients with nonulcer dyspepsia. this study assessed the effect of eradicating helicobacter pylori infection on the symptoms of nonulcer dyspepsia at four weeks and one year after treatment. dyspepsia was assessed on the frequency and severity of six symptoms [epigastric pain (night and day), nausea and vomiting, upper abdominal discomfort, and regurgitation] where each symptom was scored from 0 to 4. helicobacter pylori status was assessed before ... | 1995 | 7821097 |
| helicobacter pylori infection. a reversible cause of hypergastrinemia and hyperchlorhydria which may mimic zollinger-ellison syndrome. | the present report describes two patients with fasting hypergastrinemia, gastric acid hypersecretion, and helicobacter pylori gastritis. provocative testing for zollinger-ellison syndrome was negative and imaging studies did not demonstrate an intra-abdominal mass. following eradication of the helicobacter pylori infection, the fasting hypergastrinemia resolved in both patients and in one patient the gastric acid hypersecretion also resolved. the implications of this case on the differential dia ... | 1995 | 7821103 |
| effect of plaunotol on hypergastrinemia induced by long-term omeprazole administration in humans. | omeprazole markedly inhibits basal and stimulated gastric acid secretion and has the ability to produce hypergastrinemia and hyperplasia of enterochromaffin-like cells in humans. on the other hand, plaunotol, an acyclic diterpene alcohol, has been reported to inhibit gastrin release by stimulating endogenous secretion release. we investigated the effect of plaunotol on serum gastrin levels after six to eight weeks of omeprazole (20 mg/day) administration in 22 patients (16 males, 6 females; mean ... | 1995 | 7821104 |
| salvage synthesis of purine nucleotides by helicobacter pylori. | the incorporation of purine nucleotide precursors into helicobacter pylori and the activities of enzymes involved in nucleotide salvage biosynthetic pathways were investigated by radioactive tracer analysis and nuclear magnetic resonance spectroscopy. the organism took up the nucleobases adenine, guanine and hypoxanthine, and the nucleosides adenosine, guanosine and deoxyadenosine. any incorporation of deoxyguanosine by the cells was below the detection limits of the methods employed. the activi ... | 1994 | 7822226 |
| helicobacter pylori and ulcer in patients taking nsaids. | 1995 | 7823378 | |
| helicobacter pylori reinfection and rapid relapse of low-grade b-cell gastric lymphoma. | 1995 | 7823686 | |
| possible role of helicobacter pylori serology in reducing endoscopy workload. | we validated a commercial enzyme-linked immunosorbent assay (elisa), helico-g, in diagnosing h. pylori in 129 patients (mean age 50 years, range 15-86). we analysed the results of endoscopy against serology to see whether there was a possibility of adopting the strategy of not endoscoping dyspeptic subjects under the age of 45. h. pylori infection was considered present if either histology and/or culture were positive. the elisa had a sensitivity of 88%, specificity of 72%, positive predictive v ... | 1994 | 7824415 |
| helicobacter pylori infection and fasting serum gastrin levels in a series of endoscopically diagnosed gastric polyps. | the occurrence of h. pylori infection and the levels of fasting serum gastrin (sega) were examined in 97 patients with different morphological types of endoscopically diagnosed gastric polyps. according to the histology of the polyps the series was divided into three groups: inflammatory polyps (43 cases), polyps with foveolar hyperplasia (25 cases), and hyperplastic polyps including adenomas (29 cases). the prevalence of h. pylori infection was significantly lower in patients with hyperplastic ... | 1994 | 7826605 |
| prevalence of helicobacter pylori in southern indian controls and patients with gastroduodenal disease. | the spiral organism helicobacter pylori has been causally implicated in the genesis of various gastroduodenal diseases. since these diseases are common in southern india, this study was undertaken to determine the prevalence of h. pylori in the gastric mucosa of asymptomatic adults and patients with various gastroduodenal diseases. h. pylori was detected in the gastric mucosa of 25 of 30 (83.3%) normal volunteers. prevalence rates in the disease groups were also high, and included 38 of 41 patie ... | 1994 | 7827302 |
| colonization by helicobacter pylori and its relationship to histological changes in the gastric mucosa in portal hypertension. | in order to investigate the relationship between helicobacter pylori infection of the gastric mucosa and mucosal changes in portal hypertension, gastric fundic and antral biopsies were obtained from 66 patients with portal hypertension and 49 controls with non-ulcer dyspepsia (nud). gastric mucosa from portal hypertensive patients exhibited typical vascular dilatation and congestion, while mild dilatation of lamina propria blood vessels was not uncommon in nud patients with histological evidence ... | 1994 | 7827303 |
| gastric cytoprotection by amoxycillin in the rat. | amoxycillin in combination with anti-ulcer agents has been shown to prolong duodenal ulcer remission. while this effect can be related to the eradication of helicobacter pylori, it is not known if amoxycillin might possess cytoprotective properties. protection against ethanol-induced gastric mucosal damage by intragastric instillation of amoxycillin suspension (prepared from capsule form) and solution (from injection form, 100% pure amoxycillin), and by intraperitoneal injection of amoxycillin s ... | 1994 | 7827304 |
| inhibitory effect of polyunsaturated fatty acids on the growth of helicobacter pylori: a possible explanation of the effect of diet on peptic ulceration. | diets high in polyunsaturated fatty acids may protect against duodenal ulcer, possibly through inhibiting the growth of helicobacter pylori. this hypothesis was tested in vitro by incubating h pylori microaerophilically with a range of polyunsaturated fatty acids. omega-3 linolenic acid significantly, but reversibly, inhibited growth at 1.8, 2.5, and 5 x 10(-4) m (p < 0.01), while concentrations of 10(-3) m killed virtually all organisms, with cell lysis observed by electron microscopy. similar ... | 1994 | 7828972 |
| high prevalence of helicobacter pylori metronidazole resistance in migrants to east london: relation with previous nitroimidazole exposure and gastroduodenal disease. | a high prevalence of metronidazole resistance in helicobacter pylori is reported in developing countries. this study examined whether migrants referred for diagnostic gastroscopy at a united kingdom centre (n = 54), had a higher prevalence of metronidazole resistance than subjects born in the united kingdom attending endoscopy (n = 46). records of nitroimidazole treatment prescribed in the united kingdom was obtained in 83 patients to find out if there was an association between h pylori metroni ... | 1994 | 7828973 |
| cytokine gene expression in helicobacter pylori associated antral gastritis. | infection of the gastric antrum by helicobacter pylori is characterised by a cellular inflammatory infiltrate. whether cytokines are involved in the pathogenesis of this gastritis has been investigated by studying the effect of eradicating h pylori on the expression of genes encoding the cytokines interleukin 8 (il-8) and tumour necrosis factor alpha (tnf-alpha) in the antral mucosa. gastric antral biopsy specimens were taken from nine patients with duodenal ulcers and cytokine transcripts were ... | 1994 | 7828974 |
| improved fold width and increased acid secretion after eradication of the organism in helicobacter pylori associated enlarged fold gastritis. | this study examined the effects of eradication of helicobacter pylori (h pylori) infection on gastric mucosal morphology and acid secretion. sixteen h pylori positive patients with enlarged gastric body folds were divided into two groups: (a) patients with moderate enlargement (fold width: 6 to 10 mm, n = 8) and (b) patients with severe enlargement (> 10 mm, n = 8). after successful treatment, gastric body fold width was reduced in both groups (p < 0.01) with an associated decrease in inflammato ... | 1994 | 7828975 |
| helicobacter pylori in eastern european countries: what is the current status? | 1994 | 7829002 | |
| the susceptibility of helicobacter pylori to 12 antimicrobial agents, omeprazole and bismuth salts. | 1994 | 7829415 | |
| helicobacter pylori eradication: who, why and how in 1994? | 1994 | 7830661 | |
| [helicobacter pylori gastric infections in children]. | numerous reports have established the association of helicobacter pylori and recurrent abdominal pain in children. we investigated the clinical, bacteriological and therapeutic features of our patients seen over a 1 year period. | 1994 | 7831253 |
| [macrolides. new therapeutic prospects]. | the aim of the development of semisynthetic derivatives was to overcome the problem of chemical stability of erythromycin a in acid medium, with less variability in gastro-intestinal absorption and leading to renewed interest in macrolides. the new macrolides have the same antibacterial spectrum as erythromycin a including gram-positive and gram-negative cocci, intracellular bacteria, mycoplasma, campylobacter sp., helicobacter pylori, mycobacteria spp., gram-negative bacilli including haemophil ... | 1994 | 7831266 |
| interaction between helicobacter pylori and human gastric epithelial cells in culture: effect of antiulcer drugs. | a human in vitro model to study the interaction between helicobacter pylori and gastric epithelial cells was developed using primary cultures of gastric mucosal cells (isolated from gastric biopsies or operative specimen and maintained in culture for 2 weeks) as well as the well-differentiated human gastric carcinoma cell line hm02, the undifferentiated gastric tumour cell line hm51, and the laryngeal epithelial cell line hep-2. primary cultures and all cell lines were exposed to seven isolates ... | 1994 | 7831386 |
| treatment of helicobacter pylori infection. | 1995 | 7832607 | |
| age at establishment of helicobacter pylori infection and gastric carcinoma, gastric ulcer, and duodenal ulcer risk. | helicobacter pylori is an important risk factor for gastric cancer, gastric ulcer, and duodenal ulcer, yet most infected persons do not develop disease. we examined two correlates of acquisition age, sibship size and birth order, to evaluate the hypothesis that early life acquisition of h. pylori is a risk factor for the development of these illnesses. in earlier nested case-control studies of a cohort of japanese american men in hawaii, evidence of h. pylori infection was associated with the de ... | 1995 | 7834625 |
| [is helicobacter pylori infection the etiology of duodenal ulcer?]. | 1994 | 7834710 | |
| role of luminal ammonia in the development of gastropathy and hypergastrinemia in the rat. | chronic infection with helicobacter pylori causes persistent elevations in gastric juice ammonia levels. thus, we studied the effects of experimentally induced increases in gastric juice ammonia levels on gastric structure and function and gastrin homeostasis. | 1995 | 7835572 |
| helicobacter pylori and gastric lymphoma. | 1995 | 7835608 | |
| gastroprotective agents in mucosal defense against helicobacter pylori. | 1. convincing evidence now exists that infection with h. pylori plays a major role in the pathogenesis of gastric disease. having a niche bordering two major perimeters of mucosal defenses, the bacterium apparently exerts its detrimental effect on the mucus layer as well as the gastric epithelium. therefore, gastroprotective agents capable of counteracting these detrimental effects of h. pylori are gaining importance in the treatment of gastric disease. 2. the colonization of gastric mucosa by h ... | 1994 | 7835626 |
| inhibition of gastric mucosal mucin receptor by helicobacter pylori lipopolysaccharide: effect of sulglycotide. | 1. a receptor for mucin was isolated from the solubilized gastric epithelial cell membrane by affinity chromatography on sepharose-bound wheat germ agglutinin. 2. the receptor protein displayed a molecular weight of 97 kda and exhibited specific affinity towards mucin-coated surfaces. the optimum for mucin binding occurred at 60-100 micrograms/ml, while the values for the receptor were 2.0-3.1 micrograms/ml. 3. the mucin binding to the receptor was susceptible to helicobacter pylori lipopolysacc ... | 1994 | 7835646 |
| observer variation in the assessment of chronic gastritis according to the sydney system. | the main aims of the sydney system for the classification of gastritis are to improve uniformity in histopathological reporting and to provide a flexible matrix of rules for grading the histological features. we sought to determine the level of interobserver agreement between pathologists in the application of the sydney system. three histopathologists independently examined h & e, alcian blue/pas and modified giemsa stained sections of two antral and two corpus gastric biopsies from 69 consecut ... | 1994 | 7835836 |
| a role for cd4+ t cells from orally immunized rats in enhanced clearance of pseudomonas aeruginosa from the lung. | the role of gut-derived cd4+ t cells in clearance of pseudomonas aeruginosa from the lung was studied by cell transfer experiments. mesenteric lymph node cells from unimmunized rats, or rats orally immunized with either killed p. aeruginosa or helicobacter pylori, were transferred to naive rats which were subsequently challenged intra-tracheally with live p. aeruginosa. recipients of unseparated mesenteric lymph node cells, purifed t cells or cd4+ t cells, from p. aeruginosa-immunized donors, al ... | 1994 | 7835960 |
| [analysis of immune response to helicobacter pylori--identification of the protein recognized by anti-helicobacter pylori antibodies from sera of patients with gastroduodenal diseases]. | hp-specific antibodies were measured in each collected fraction obtained from gel-filtrated separation method with selected patients sera by enzyme-linked immunosorbent assay (elisa). most of the fractions reacted with the patients sera also responded to hp urease-specific monoclonal antibodies. in addition, the fractions which showed urease activity strongly correlated with the hp antibody positive ones. also, we could not detect any cross-reactivity to ureases of other species. moreover, most ... | 1994 | 7837686 |
| prevalence of helicobacter pylori antibodies in uremic patients. | 1994 | 7838282 | |
| quality of life and relapse of duodenal ulcer before and after eradication of helicobacter pylori. | the aim of the study was to compare relapse rates and quality of life before and after eradication of helicobacter pylori in a group of patients with documented recurrent duodenal ulcer disease. | 1994 | 7839092 |
| intravenous omeprazole/amoxicillin and omeprazole pretreatment in helicobacter pylori-positive acute peptide ulcer bleeding. a pilot study. | the aims of this study were to evaluate a helicobacter pylori eradication schedule for h. pylori-positive gastroduodenal ulcer bleeding, which could be commenced intravenously after endoscopic diagnosis, and to assess the effect of omeprazole pretreatment on bacterial eradication. | 1994 | 7839093 |
| distinct profiles of gastritis in dyspepsia subgroups. their different clinical responses to gastritis healing after helicobacter pylori eradication. | a contribution of helicobacter pylori gastritis to the pathogenesis of non-ulcer dyspepsia (nud) remains uncertain. | 1994 | 7839094 |
| helicobacter pylori and peptic ulcer disease. | since william beaumont's classic description of gastric physiology in 1847, the focus of clinical practice and basic research concerning gastric and duodenal ulcers has centered on the secretion of acid and pepsin. in addition to these well-known factors (largely determined by heredity, age, and oral intake), the search for other agents that alter the mucosal barrier has identified a bacillus, helicobacter pylori, as a significant agent in the development of chronic gastritis and benign gastric ... | 1995 | 7839956 |
| standardization of disk diffusion test and its clinical significance for susceptibility testing of metronidazole against helicobacter pylori. | susceptibilities of 121 clinical helicobacter pylori strains to metronidazole were determined by both a 5-micrograms metronidazole disk diffusion test and a plate dilution method in duplicate and after different periods of incubation. the distribution of mics of metronidazole against h. pylori among the strains was found to be bimodal. the diameters of inhibitory zones obtained by the disk diffusion test and the mics obtained by the plate dilution method correlated well, especially after 4 days ... | 1994 | 7840570 |
| oesophageal and gastric carcinoma in the republic of yemen. | we conducted a preliminary survey on 3064 patients who underwent upper gastrointestinal endoscopy at the al-thawra hospital in sana'a, republic of yemen, between january and december 1991. the age/sex distribution, demographic features and social habits with respect to cigarette and water-pipe smoking and qat chewing were compared for patients with oesophageal and gastric cancers (n = 183). a preponderance of women with carcinoma of the mid-oesophageal was noted, previously only recorded in area ... | 1995 | 7841062 |
| role of helicobacter pylori infection in gastro-duodenal secretion and in pathogenesis of peptic ulcer and gastritis. | etiologic role for hp appears to be best established in histologically proven gastritis. the major factors mediating gastritis induced by the colonization of the "gastric type" mucosa with hp are probably cytotoxins, cytokines and free radicals activated by this organisms. the deficiency of negative feedback in somatostatin-gastrin link in antral gastritis may result in an excessive gastrin release and increased gastric acid secretion with increased duodenal acid load under basal state and after ... | 1994 | 7841447 |
| antibodies against some bacterial antigens in children. | the prevalence of bacterial antibodies was determined in 173 children aged 0-15 years. the prevalence of igg borrelia burgdorferi antibodies in titres > 500 in children less than 8 years of age was 6% while none of the older children had these antibodies in titres > 400. igg helicobacter pylori antibodies were detected only in children older than 6 years of age, with a prevalence of 6.5%, as were iga h. pylori antibodies, with a prevalence of 3.7%. the prevalence of high-titre igg campylobacter ... | 1994 | 7841725 |
| [malt lymphoma, stomach carcinoma--role of helicobacter pylori. are chances for prevention on the horizon?]. | the pathogenesis of gastric carcinoma developing after infection with helicobacter pylori now seems to be clear. the release of urease, alcohol dehydrogenase, enzymes and cytotoxin on the one hand, and chemotactic factors, paf and heat-shock proteins on the other trigger chronic inflammation and epithelial metaplasia and dysplasia in the stomach. under the influence of additional carcinogens, the epithelial changes progress to severe dysplasia and finally carcinoma. as a result of chronic inflam ... | 1994 | 7843683 |
| virulence of coccoid and bacillary forms of helicobacter pylori in gnotobiotic piglets. | this study sought to determine if coccoid forms of helicobacter pylori are virulent for gnotobiotic piglets. coccoid forms were generated by maintaining broth cultures of h. pylori under microaerobic conditions for 16 days. the resulting cultures contained bacteria with a coccoid morphology that could not be cultured in vitro. coccoid h. pylori did not colonize any of 6 gnotobiotic piglets that were inoculated, whereas bacillary h. pylori colonized 6 of 6 inoculated piglets. piglets colonized by ... | 1995 | 7844390 |
| [an enzyme-linked immunosorbent assay for the detection of igg antibodies against urease of helicobacter pylori]. | we have developed an enzyme-linked immunosorbent assay (elisa) for the detection of igg antibodies against helicobacter pylori (hp) using purified hp urease as an antigen. the urease was purified from ultrasonicated extract of hp by nacl linear gradient system on deae-sepharose 4b chromatography. two molecular weight bands, 65kd and 27kd were observed on a sds-page gel in the purified urease sample. the urease antigen did not crossreact to rabbit antibodies prepared against campylobacter coli an ... | 1994 | 7844892 |
| [helicobacter pylori eradication therapy with omeprazole and amoxicillin: current status]. | combined therapy with the proton pump inhibitor omeprazole and amoxicillin has become an important alternative in the treatment of ulcer disease associated with helicobacter pylori infection. due to the high efficacy in eradicating h.pylori, missing resistance of h.pylori against amoxicillin and high tolerability and digestibility this regimen may be recommended for widespread routine use. in a randomized, double-blind multicenter trial an h.pylori eradication rate of over 90% has been achieved ... | 1994 | 7845167 |
| benefits from elimination of helicobacter pylori infection include major reduction in the incidence of peptic ulcer disease, gastric cancer, and primary gastric lymphoma. | it has recently been recognized that gastritis, gastric ulcer, duodenal ulcer, gastric carcinoma, and primary gastric b-cell lymphoma are all associated with gastroduodenal infection with the bacterium helicobacter pylori. ten percent of americans develop a peptic ulcer: one in six of those is infected. four to five million americans have peptic ulcer disease and ulcer disease is responsible for $43 to $44 billion in annual health care costs. | 1994 | 7845945 |
| [13c]urea breath test to confirm eradication of helicobacter pylori. | to determine the utility of the [13c]urea breath test in confirming the eradication of helicobacter pylori. | 1995 | 7847290 |
| conventional cleaning and disinfection techniques eliminate the risk of endoscopic transmission of helicobacter pylori. | to determine whether endoscopes serve as a reservoir for helicobacter pylori and whether two commonly used cleaning and disinfection methods eliminate the risk of h. pylori transmission. | 1995 | 7847291 |
| mucopeptic cell expansion in gastric foveolar epitheleum in helicobacter pylori-positive, body-fundic chronic superficial gastritis. | 1995 | 7847320 | |
| purification and characterization of helicobacter pylori alcohol dehydrogenase. | alcohol dehydrogenase of helicobacter pylori (hpadh) was purified from the soluble fraction of cultured bacteria (strain nctc 11637) by anion exchange and affinity chromatography. on sodium dodecyl sulfate-polyacrylamide gel electrophoresis, the 160-fold purified enzyme displayed one protein band with a mobility that corresponded to an m(r) of 38,000. although hpadh was capable of utilizing both nadp and nad as cofactors in alcohol oxidation, it showed a strong preference for nadp over nad. kine ... | 1994 | 7847610 |
| helicobacter pylori and peptic ulcer. | 1995 | 7847658 | |
| pharmacokinetic optimisation of the treatment of peptic ulcer in patients with renal failure. | the pathogenesis of peptic ulceration is not yet clear. it could be due to an imbalance between acid secretion and mucosal defensive and/or protective mechanisms, but the association between helicobacter pylori and peptic ulceration has questioned this hypothesis. therefore, drugs inhibiting acid secretion and/or eradicating h. pylori are of major interest. peptic ulcer disease is often associated with renal failure. for the selection of the proper dosage of these agents their pharmacokinetic pr ... | 1994 | 7851056 |
| in vitro activity of cp-99,219, a novel 7-(3-azabicyclo[3.1.0]hexyl) naphthyridone antimicrobial. | the in vitro activity of cp-99,219 was compared with that of ciprofloxacin and sparfloxacin against 814 clinical bacterial isolates using a microdilution method with brain-heart infusion broth. cp-99,219 was the most potent agent tested against methicillin-resistant, ciprofloxacin-susceptible staphylocci (minimum inhibitory concentration [mic]90 < or = 0.25 microgram/ml). cp-99,219 was 32-fold and fourfold more potent than ciprofloxacin and sparfloxacin, respectively, against streptococcus pneum ... | 1994 | 7851087 |
| products of neutrophil metabolism increase ammonia-induced gastric mucosal damage. | recent studies have indicated that ammonia is involved in the pathophysiology of helicobacter pylori-associated gastric mucosal damage. helicobacter pylori-associated chronic active gastritis is characterized by an invasion of neutrophils. we investigated the interrelationship among hypochlorous acid (oxidant produced by neutrophil), ammonia (product of helicobacter pylori urease), and monochloramine (product of ammonia and hypochlorous acid) in the development of gastric mucosal damage in rats. ... | 1995 | 7851188 |
| ecological study of association between helicobacter pylori infection and gastric cancer in taiwan. | the association between helicobacter pylori infection and gastric cancer remains controversial. a community-based serosurvey was carried out in taiwan to investigate the association. serum igg antibodies against helicobacter pylori were examined in 728 subjects randomly selected from three townships with different gastric cancer mortality rates. the overall seropositivity of helicobacter pylori was 54.7% (398/728) with no gender difference (males: 54.5%; females: 54.8%). the seroprevalence of he ... | 1995 | 7851203 |
| helicobacter pylori, gastroduodenal disease, and recurrent abdominal pain in children. | to assess the evidence for a cause-and-effect relationship between helicobacter pylori infection and antral gastritis, peptic ulcer disease, and recurrent abdominal pain in children. | 1995 | 7853632 |
| endoscopic cross-infection with helicobacter pylori. | 1995 | 7853991 | |
| reliability of two commercial serological kits for serodiagnosing helicobacter pylori infection. | two commercial serological kits, pylori-set (orion diagnostica, finland) and helico-g (cambridge biomedical ltd, uk), and an in-house elisa were evaluated with sera from 24 helicobacter pylori-positive and 146 h. pylori-negative dyspeptic patients. sensitivity, specificity, positive and negative predictive values of pylori-set were lower than that of helico-g and in-house elisa. helico-g was more sensitive (91.7%) than in-house elisa (83.3%) and both had comparable negative predictive values of ... | 1994 | 7855648 |
| the risk of helicobacter pylori infection among u.s. military personnel deployed outside the united states. | to determine whether military personnel deployed outside the united states are at increased risk of helicobacter pylori infection, 1,000 male u.s. navy and marine corps personnel (mean age 22 years) were evaluated. study subjects included 200 recruits, 500 shipboard personnel deployed for six months to south america, west africa, and the mediterranean, and 300 ground troops deployed for five months to saudi arabia. among all 1,000 subjects, 247 (25%) were seropositive for h. pylori igg antibody ... | 1995 | 7856819 |
| [helicobacter pylori in peptic ulcer and gastric cancer]. | recently many reports have shown a strong association between helicobacter pylori infection in the stomach and recurrent peptic ulcer. moreover, prospective cohort serological studies showed that h. pylori infected individuals have significantly increased rate of gastric cancer in the usa. h. pylori is a gram-negative spiral organism which has urease activity and produces ammonia and co2 from urea, and nestles in the gastric pits and overlaying mucus gel layer. many diagnostic methods of h. pylo ... | 1995 | 7857088 |
| serodiagnosis of helicobacter pylori: evaluation of a rapid, miniaturized immunochromatographic test. | diagnosis and successful eradication of helicobacter pylori infection has been shown to be significantly related to symptom improvement in patients affected by chronic gastritis, duodenal and gastric ulcer. there is, therefore, an increasing need for the development of new, easy to use, reliable and non-invasive techniques to detect this organism. one such test is flex-sure (smithkline diagnostics inc., united states), a new, rapid immunochromatographic test which requires a drop of the patient' ... | 1994 | 7858477 |
| effects of acid suppression on microbial flora of upper gut. | decreased acid secretion, due to therapy or disease, predisposes to increased bacterial counts in gastric juice. as bacterial numbers increase, the number of nitrate-reducing strains and the concentration of luminal nitrite usually also increase. however, there is controversy (mainly because of assay problems) about whether decreased acid increases generation of n-nitroso compounds: these may be produced by acid or by bacterial catalysis, and the relative contributions of each are still uncertai ... | 1995 | 7859586 |
| pathophysiological effects of long-term acid suppression in man. | a critical evaluation has been made of the available evidence in man of the effects of prolonged low acid states on the structure and function of the stomach. various human models have been examined. 1. ageing does not affect acid output from the normal male stomach, and there may be an increase in women. with progressive atrophy of the corpus mucosa, which is more frequent and rapid in patients with gastric ulcer, there is an associated loss of secretory function. chronic gastritis and atrophy ... | 1995 | 7859587 |
| prevalence of helicobacter pylori antibodies in the serum of gastroenterologists in austria. | eighty-eight endoscopists (mean age 41 years, range 29-76 years) and a control group of 100 persons of similar ages were investigated for the prevalence of antibodies (abs) to helicobacter pylori, using a quantitative enzyme-linked immunosorbent assay (elisa) to igg, two semiquantitative elisas to igg and iga, and a latex test to igg and igm antibodies. the prevalence of antibodies to h. pylori in endoscopists was 48% (quantitative elisa), 56% (semiquantitative elisa to igg), 62% (latex test), a ... | 1994 | 7859680 |
| helicobacter pylori seroepidemiology in risk groups. | helicobacter pylori is associated with peptic ulcer and chronic active gastritis. the response to infection can be determined by measuring serum titers of anti-h. pylori antibodies. we compared antibody titers in 612 serum samples from 570 individuals considered at risk for h. pylori infection, 170 of them are control sera from 110 adults and 60 children with no gastric alterations. the study groups were 93 institutionalized mentally handicapped children, 40 heterosexual couples, 101 hiv-sero-po ... | 1994 | 7859841 |
| working group report on schistosomes, liver flukes and helicobacter pylori. | 1995 | 7860130 | |
| fulminant pseudomembranous colitis (pmc) following triple therapy for helicobacter pylori. | 1994 | 7861345 | |
| evaluation of a commercial elisa kit for the serological diagnosis of helicobacter pylori infection. | h. pylori infection can be diagnosed serologically. we evaluated an elisa kit (helicobacter pylori igg, diesse) prepared using a glycine extract of an autoctonous h. pylori strain which produced the highest biologically active urease titre out of five strains tested. the kit was tested with serum samples from h. pylori-infected and uninfected adults and children. the western blot technique was used as reference method for the h. pylori infective status. based on the results obtained by immunoblo ... | 1994 | 7861988 |
| [helicobacter pylori in patients with diseases of the upper part of the gastrointestinal tract]. | among the patients subjected to esophoagogastroduodenoscopy because of different clinical indications, 108 were examined for the presence of helicobacter pylori in the antral gastric mucosa. microbiological analysis of the antral gastric mucosa biopsies were conducted by direct microscopy, the urease test and by growing in nutritious media. positive findings were recorded in 38 (86.36%) patients with endoscopically diagnosed chronic gastritis, 29 (80.56%) patients with duodenal ulcer and 19 (67. ... | 1993 | 7862044 |
| helicobacter pylori phenotypes associated with peptic ulceration. | persistent infection with helicobacter pylori occurs in a large percentage of the population, particularly in countries with low socioeconomic status. such infection nearly always produces chronic gastric inflammation, although in most individuals it is clinically silent and only a minority of infected persons develop h. pylori-induced peptic ulcers. in this review, the hypothesis that diversity among h. pylori strains is at least partly responsible for the observed variability in the outcome of ... | 1994 | 7863235 |
| helicobacter pylori in peptic ulcer disease. proceedings of a symposium. brussels, belgium, 23 september 1993. | 1994 | 7863236 | |
| epithelial cytotoxicity, immune responses, and inflammatory components of helicobacter pylori gastritis. | to clarify the mechanisms of the gastric mucosal immune--inflammatory response to helicobacter pylori infection, surgical and biopsy specimens from asymptomatic uninfected, gastritis-free individuals and from h. pylori-positive ulcer patients with chronic gastritis were investigated using light and electron microscopy. activation of the antigen-transporting endocytic--endosomal system, enhanced expression of the antigen-processing enzyme cathepsin e and de novo expression of antigen-presenting h ... | 1994 | 7863237 |