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[reactivity of peripheral blood granulocytes in aspergillus fumigatus infection]. 1979388880
a trial of isolating a tumor-like form of pulmonary cavities infected with aspergilli. ii. intra- and postoperative, morphologic and serologic data.in ten specimens of resected pulmonary tissue, a little known and underscribed form of aspergillosis called tumor-like blocked pulmonary cavity with liquid content infected with aspergilli was observed. this designation was based on the finding in the specimens of tumor-like cavitary structures with blocked bronchus and contents from which abundant growth of aspergillus fumigatus was invariably obtained in cultures. nine of the ten specimens were bronchiectasis, and one was a bronchogenic cyst. ...1978389368
[aspergillosis of the nose and paranasal sinuses]. 1979390917
intradural extramedullary aspergilloma complicating chronic lymphatic leukaemia. 1979391317
response to bronchial provocation and exercise in children with cystic fibrosis.ten of fifteen cystic fibrosis children with positive skin prick tests to common antigens gave an immediate bronchial reaction to the antigen inhaled, five of them also gave a late reaction; however only one gave a history of asthma. the antigen most commonly eliciting a positive skin reaction in cystic fibrosis patients is aspergillus fumigatus. in six children tested to this antigen the bronchial response varied, two were negative, one gave an immediate reaction and three gave a dual (immediat ...1979391435
aspergillus fumigatus and lung disease.the range of clinical presentations of lung diseases associated with aspergillus spp. is great. the conditions are very frequently misdiagnosed but errors should be avoided if the possibility of a fungal cause is considered and simple immunological tests undertaken. often no more than skin-prick tests and serum precipitins need to be done. in many cases, fungus is not isolated from the sputum and negative results do not exclude the possibility of a. fumigatus as the causal agent. treatment often ...1979392479
exposure of rabbits to spores of aspergillus fumigatus or penicillium sp: survival of fungi and microscopic changes in the respiratory and gastrointestinal tracts.rabbits were exposed to spores of aspergillus fumigatus by 1 of 2 routes: exposure to aerosols of dry spores or introduction of liquid suspensions of spores directly into the stomach. rabbits also were exposed to aerosols containing spores of a penicillium sp. cultural and microscopic examinations of tissues from the respiratory and gastrointestinal tracts indicated fungi were distributed throughout the gastrointestinal tract of the rabbits within 1 hour after exposure to aerosols of a fumigatus ...1979393142
thermophilic and thermotolerant fungi in poultry droppings in nigeria.ten species of fungi were obtained from poultry droppings in nigeria. six of these are true thermophiles while the other four are thermotolerant. aspergillus fumigatus fresenius, mucor pusillus lindt and thermoascus aurantiacus stolk are known human pathogens. except for m. pusillus, all the thermotolerant species had a higher occurrence at 45 degrees c while the thermophilic varieties were readily obtained at 50 degrees c.1979393797
[enzymolysis of the acidic hydrolysates of plant residues]. 1979393967
haemoptysis in eosinophilic granuloma.eosinophilic granuloma of bone may involve the lung in about 20% of cases (lewis 1964); and may present in the lung without other organ involvement. haemoptysis occurs in about 10% of cases for unknown reasons. i document here a case with typical presentation and course, but which was complicated by haemoptysis of increasing severity leading to death. the cause of haemoptysis was diagnosed at fibreoptic bronchoscopy.1979394756
endogenous fungus endophthalmitis (probably aspergillus).a 53-year-old organic chemist developed severe asthma and bronchitis a few weeks after professional exposure to plant dust. 15 days later an acute severe endophthalmitis occurred. both the systemic and eye conditions were treated with corticosteroids and antibiotics. the atrophic eye which was enucleated 6 months later histologically revealed abscesses in the iris, ciliary body, lens and vitreous harbouring numerous islands of septate, dichotomously branching hyphae, orientated in the same direc ...1979395478
[results of local treatment of pleural aspergillosis]. 1979395511
isolation of some new tryptoquivaline-related metabolites from aspergillus fumigatus. 1979396046
investigation of the hemolytic site of asp-hemolysin. 1979396392
the effect of beta-glucuronidase and chitinase on the cell wall of aspergillus niger and aspergillus fumigatus.the effects of beta-glucuronidase and chitinase have been tested on the hydrolysis of the cell walls of the economically important fungi, aspergillus niger and aspergillus fumigatus. the extent of wall hydrolysis was measured by assaying for total reducing sugars, n-acetyl sugars and protoplast production. maximum reducing sugar release was attained after 40 min incubation, both with beta-glucuronidase supplemented with chitinase and beta-glucuronidase alone, whereas n-acetyl sugar release reach ...1979396451
a guide to the recent literature on aspergillosis as caused by aspergillus fumigatus, a fungus frequently found in self-heating organic matter.spores of aspergillus fumigatus have been found to be abundantly present in the outdoor air at a site where large scale experimental composting of sewage sludge is in progress at beltsville, maryland. the health significance of this finding, for that site and for others in the future, is still only incompletely understood. further studies are in progress to characterize absolute concentrations of the spores of the fungus in air at the site, spore dispersal by air from composting operations, and ...1979396477
[pulmonary atelectasis caused by bronchocentric aspergillosis: an other farmer's pneumoconiosis]. 1979396705
germination of non-irradiated and gamma-irradiated fungal spores on water agar and natural soil.germination and germ-tube lengths of non-irradiated and gamma-irradiated spores of eight soil fungi were studied on water agar and on natural soil. non-irradiated spores showed variable degrees of sensitivity to the fungistatic factor in natural soil. lower doses of gamma-irradiation (5 k rad) produced stimulus to germination and germ-tube lengths without losing the fungistatic properties of the fungi concerned. germination at the rest of treatments (100 and 500 k rad) showed significant inhibit ...1979396932
structure-activity relationships in fusidic acid-type antibiotics. 1979397741
[frequency of fungal infection in chronic bronchitis and bronchiectasis (author's transl)].among 1 161 patients with chronic bronchitis and 172 patients with bronchiectasis treated for a longer time with antibiotics or with antibiotics and corticosteroids and examined all for fungi in bronchial secretion, 34 = 0.9% showed a secondary infection with fungi (32 candida, 2 aspergillus fumigatus).1979398098
inhaled beclomethasone dipropionate in allergic bronchopulmonary aspergillosis. report to the research committee of the british thoracic association.a double-blind multi-centre study was carried out to assess the effects of beclomethasone dipropionate aerosol on the control of symptoms of asthma and on fungal colonization of the bronchi, in patients with allergic bronchopulmonary aspergillosis who had not been treated with an inhaled corticosteroid preparation for at least six months. each of the 32 patients who completed the trial was treated with beclomethasone (100 microgram four times daily) or placebo aerosol for consecutive periods of ...1979400108
[intracavitary inclusion]. 1979400278
prevalence of aspergillus and candida precipitins in renal dialysis and transplant patients.serum precipitin tests to aspergillus and candida antigens were used to define the rate of infectivity with these fungal organisms in patients on renal dialysis and after kidney transplantation. a total of 58 studies in 53 consecutive patients, of whom 41.5% were post-transplant an average of 14.6 months, failed to detect significantly more precipitin activity than in a normal population. the specificity of this non-immunoreactivity was supported by the absence of clinical or post-mortem evidenc ...1979400842
immunological aspects of infection and allergy due to aspergillus species. 1978400877
mycotic infection of the paranasal sinuses. 1978400886
detection of aspergillus fumigatus precipitins: a comparison of counter immunoelectrophoresis and double diffusion.a counter immunoelectrophoresis method was compared with a double diffusion test for detecting aspergillus fumigatus antibodies. of 70 patients, 23 gave positive results in both tests and the remainder gave negative results. fifteen patients with proven aspergillosis gave positive results in both tests.1977404338
the diagnosis of aspergillus fumigatus infection of the nasal chambers of the dog with particular reference to the value of the double diffusion test. 1977404470
experimental aspergillosis in buffaloes: histopathological, histochemical and serological studies. 1977405583
modified indirect fluorescent-antibody test for aspergillosis.diffuse fluorescence in an indirect fluorescent-antibody test for antibody to aspergillus fumigatus was eliminated by using germlings, rather than hyphae, as antigen. the modified method yielded diagnostic titers larger than or equal to 1:32 in 24 of 25 known cases, was highly specific, and showed good correlation with clinical status and results of immunodiffusion. this technique, which uses the germling antigen, inactivation of test serum at 59 +/- 1 degrees c, and anti-immunoglobulin g conjug ...1977408374
variability of extracts used in immunoprecipitin tests.immunodiffusion reactions of several different commercial fungal extracts from organisms were compared to those obtained from patients' environments. sera were obtained from patients suspected of having hypersensitivity lung disease (hld). there was a difference in reactivity among the sources of the antigen and in some lots of antigen from the same commercial supplier. the results demonstrate a wide variation in the reactivity of different antigenic extracts and emphasize the need for uniform s ...1977409751
opportunistic mycotic osteomyelitis: bone infections due to aspergillus and candida species. 1977411015
clinical and therapeutic significance of patterns of allergic reactions of the lungs to extrinsic agents: the 1977 j. burns amberson lecture. 1977411403
a comparative investigation of the bactericidal and fungicidal effects of three phenolic disinfectants. 1977412825
sensitivity to 5-fluorocytosine and virulence for mice of some human isolates of aspergillus.the sensitivity of 5-fluorocytosine (5-fc) and the virulence for mice was assessed for 16 human isolates of aspergillus: a. fumigatus 2, a. niger 7, a. flavus 4, a. terreus 2 and a. conicus (a. restrictus group) 1. fourteen strains were recovered from ear exsudates, 1 from sputum and 1 from the pus of mastoid cells of an autopsy case with meningeal and cerebral involvement. nine of them, which included strains of a. fumigatus and a. niger were sensitive to 5-fc (m.i.c. less than or equal to 6.4 ...1977413042
[mycologic study of the bronchial aspirates of patients with chronic lung diseases]. 1977414489
dual skin test reactions and serum antibodies to subtilisin and aspergillus fumigatus extracts. 1978414857
a primate model of allergic bronchopulmonary aspergillosis.allergic bronchopulmonary aspergillosis (aba) in man is featured by the presence of ige skin sensitizing and igg precipitating antibodies against aspergillus fumigatus (af). an animal model of this disease was created. 2 monkeys immunized with af produced igg-precipitating antibody. normal human serum was infused into both immunized and unimmunized monkeys and allergic human serum containing a high titer of ige against af was infused into another pair of immunized and unimmunized monkeys. all mo ...1978415985
culture and antigen variants of aspergillus. 1978416063
specific double diffusion microtechnique for the diagnosis of aspergillosis and paracoccidioidomycosis using monospecific antisera.using experimental reference sera against species-specific antigens of aspergillus fumigatus and paracoccidioides brasiliensis in a microdouble diffusion technique, a simple and specific test for the immunodiagnosis of aspergillosis and paracoccidioidomycosis has been developed. only sera that produced lines of identity with either one of the bands formed by the anti-c2 or the anti-e2 reference sera were considered positive for aspergillosis or paracoccidioidomycosis, respectively. the sensitivi ...1978416505
[pulmonary and hepatic aspergillomas in the deer].four solitary aspergillomas in deer are being described. two were found in the lungs and two in the liver. morphologically, they were bulky, local lesions filled with homogenous, fragile, necrotic tissue of conspicuously green color. pulmonary aspergillomas communicated with the conducting bronchus having affected fibers. the necrotic tissue of aspergillomas was interwoven by diffuse abundant fibers of aspergillus fumigatus.1978416550
evaluation of methods to detect antibodies against aspergillus fumigatus.seventy-five sera, including sera from 23 patients with aspergillosis, 17 with tuberculosis, asthma or carcinoma, and 35 normal controls, were studied for antibody activity against aspergillus fumigatus by agar gel double diffusion (dd), counterimmunoelectrophoresis (cie), indirect hemagglutination (iha) and indirect immunofluorescence (if). metabolic antigens produced from a selected strain of a. fumigatus were used for dd, cie and iha, while slide cultures of the same organism were used for if ...1978417619
[new toxins from aspergillus fumigatus fresenius].a strain of aspergillus fumigatus fres., isolated from sugar-beet draffs, synthesizes in vitro four toxic metabolites which have not yet been described in these fungal species. toxic effects of the most abundant of these metabolites "fumitoxin a" have been studed on chick embryo. artemia salina larvae, cell cultures, and on mice.1978418904
allergic bronchopulmonary aspergillosis in pediatric practice.twelve cases of allergic bronchopulmonary aspergillosis in the pediatric age group are reported. the average age of diagnosis was 14.5 years with a range from 6 to 18 years. all patients had a history of pulmonary infiltrations or atelectasis or both documented by chest radiographs. eight patients had bronchograms or tomograms, and seven of them showed proximal bronchiectasis. total serum ige concentrations were elevated in all patients. preciptitating antibodies against aspergillus fumigatus we ...1979423017
evaluation of long term tobramycin therapy in patients with cystic fibrosis and advanced pulmonary disease.to nine cystic fibrosis patients with chronic bronchopulmonary infection of severely damaged lungs invaded by pseudomonas aeruginosa, eleven courses of prolonged tobramycin treatment (5 mg/kg/day) for four to 16 weeks were administered. pulmonary symptoms improved and a better quality of life was achieved in all but one patient. objective parameters (chest x-ray, pulmonary function tests) changed to a lesser extent. in only one patient was pseudomonas eradicated from the sputum but reappeared af ...1979436850
toxigenic fungi isolated from roquefort cheese.to evaluate the potential for mycotoxin production by fungi contaminating blue-veined cheese, as well as by the ripening fungus, penicillium roqueforti, the fungal flora of six of local and imported brands was determined. a total of 19 fungi were isolated from the six brands tested. fourteen of the isolates were toxic to chicken embryos. the toxigenic fungi produced the following mycotoxins: aspergillus fumigatus, kojic acid; a. versicolor, sterigmatocystin; penicillium roqueforti, penicillic ac ...1979440405
the occurrence and treatment of false positive reactions in enzyme-linked immunosorbent assays (elisa) for the presence of fungal antigens in clinical samples.non-specific positive reactions have been revealed in enzyme-linked immunosorbent assays (elisa) of sera for the presence of fungal antigen. these false positives were recognized by their occurrence in tests for both candida albicans and aspergillus fumigatus antigens and by their response to dithiothreitol, combined with their reaction with non-immune rabbit globulin. a scheme is proposed which differentiates between true and false positive reactions. use of fractionated anti-fungal globulin in ...1979469266
fungus species isolated from commercial hatcheries in alabama.selected locations (incubators, incubator rooms, hatchers, hatcher rooms, chick pools, and egg rooms) in six commercial broiler hatcheries in alabama were sampled for fungus species over a 12-month period (may 1977-april 1978) by open-plate techniques (cornmeal agar or sabouraud's dextrose agar). colonies at each location were counted at 24, 48, and 72-120 hours postexposure. thirty-five species representing 21 genera were identified. the most prevalent genera were cladosporium, penicillium, asp ...1979486003
an imidazole derivative (econazole) as an antifungal agent in cell culture systems.econazole, an imidazole derivative, was tested as an antifungal agent in different cell culture systems. in comparison with fungizone, econazole has the following advantageous properties: higher stability, higher solubility, better antifungal activity against contaminants of cell cultures and a wider range between minimal inhibitory to cytotoxic concentration with aspergillus fumigatus, candida albicans and penicillium sp., activity against gram-positive bacteria and lower price. econazole exert ...1979521035
aspergillus sinusitis.since 1969, 79 cases of fungal maxillary sinusitis have been diagnosed. forty-nine were due to aspergillus fumigatus. there were no underlying diseases which depressed cellular immunity and no patient was receiving immunosuppressive drugs or corticosteroids. most patients had received antibacterial therapy before the appearance of fms. treatment was by surgery, nystatin and econazole.1979523351
occupational hypersensitivity lung disease.a case of occupational hypersensitivity pneumonitis caused by an air conditioning unit is presented. aspergillus fumigatus and aureobasidium pullulans were cultured from this unit and antibodies to these organisms were found the patient's blood. the case shows that this disease may present in a very subtle form and may be diagnosed by a culture from the patient's environment and an easily performed blood precipitin test. the importance of searching for this type of lung disease and the need for ...1978569690
fungal antigens as a source of sensitization and respiratory disease in scottish maltworkers.mycological and serological studies were carried out as part of a survey of respiratory disease in scottish maltworkers. 70% of stained sputum smears from 574 workers showed the presence of higher plant cells and/or myclelia, and the spores of common environmental fungi. penicillium spp. (90%), rhizopus stolonifer (48%) and yeasts (53%) were the dominant fungi in 699 sputum cultures, and showed a similar proportional distribution in 327 samples of grain, malt, culms and dusts from fifty-six malt ...1977589785
fungus infection of ear.of 2,632 patients seeking medical help for symptoms pertaining to the ear, 1,264 were clinically suspected to be suffering from fungus infection. microbiological confirmation of diagnosis was obtained in 209 cases including 82 cases with mixed infections (both fungus and bacteria). the commonest species of fungus isolated was aspergillus (aspergillus niger, 67%; aspergillus fumigatus, 24%). best results in fungus infection of the ear was obtained by daily packing of the external meatus by a wick ...1977615577
cellulose-decomposing fungi of salt marshes in egypt.seventy-five species and three varieties which belong to thirty-four genera were identified from 74 soil samples collected from salt marshes in egypt. the most frequent fungi were aspergillus fumigatus, aspergillus niger, cladosporium herbarum and alternatia alternata, followed by aspergillus terreus, curvularia spicifera and penicillium notatum. six genera were of moderate occurrence: penicillium, fusarium, curvularia, rhizopus, stachybotrys, and chaetomium. five genera were of low occurrence: ...1978624509
allergic bronchopulmonary aspergillosis (abpa): studies on the general and specific humoral response.serum specimens from 138 patients suffering from chronic respiratory disorders including 63 with allergic bronchopulmonary aspergillosis (abpa), 2o with suspected abpa, 15 with pulmonary tuberculosis, 14 with bronchial asthma, 10 with chronic bronchitis and 6 with miscellaneous pulmonary conditions were studied for circulating antibodies to aspergillus. the ammonium sulfate test was empolyed with an iodine-125 labeled mycelial component derived from aspergillus fumigatus. when compared to normal ...1978652026
invasive aspergillosis: antiserum for circulating antigen produced after immunization with serum from infected rabbits.we describe a method for producing an antibody capable of detecting an antigen of aspergillus fumigatus in serum and urine from infected rabbits and humans.1978669813
in vitro studies with ambruticin, a new antifungal antibiotic.the in vitro antifungal inhibitory activities of ambruticin and of various antifungal drugs of choice against 190 fungal pathogens representative of the major human mycoses were compared using a modification of the ics agar dilution technique. ambruticin compared favorably with amphotericin b and miconazole when tested against the dimorphic pathogens coccidioides immitis, histoplasma capsulatum, and blastomyces dermatitidis and against aspergillus fumigatus. miconazole was the most active compou ...1978686712
in vitro comparison of the antifungal activities of r34,000, miconazole and amphotericin b.in vitro susceptibilities of 78 isolates of pathogenic filamentous fungi to the imidazole compounds r34,000 and miconazole and to amphotericin b were determined using an agar dilution technique. allescheria boydii, sporothrix schenckii and the dematiaceous fungi (cladosporium, fonsecaea and phialophora spp.) were most susceptible to miconazole with minimum inhibitory concentration (mic) values ranging from less than or equal to 0.25 to 32 microgram/ml and with geometric mean mic (g-mic) values o ...1978699677
[chronic septic granulomatosis imitating exogenic allergic alveolitis (farmer's lung)].a 17-year-old boy demonstrated clinical and immunological signs of exogenic allergic alveolitis (farmer's lung). the patient grew up in the country and suffered from recurrent "pneumonia." in his serum precipitins were detected against micropolyspora faeni, aspergillus fumigatus and hay. transbronchially obtained lung tissue showed histologically an inflammation of the epitheloid-cell-granulomatous type with fibrosis. a congenital defect of the neutrophilic function was suspected in view of the ...1978700576
role of opportunistic fungi in ocular infections in nigeria.the importance of opportunistic fungal pathogens in causing ocular infections is emphasized. a study was conducted over a period of 4 years (1974--1977) to investigate the role of opportunistic fungi in causing mycotic keratitis and to elucidate certain aspects of epidemiology of this disease in nigeria. fifty-nine cases of corneal ulcers of suspected mycotic etiology were investigated. fungal etiology was confirmed in 42 of these cases. the predominant etiological agent was fusarium solani in 1 ...1978745623
[isolation of phthioic acid of aspergillus fumigatus and its biological activities]. 1975765548
[isolation and purification of hemolytic toxin of aspergillus fumigatus]. 1975765557
[fungi in bronchial secretion of children with nonspecific bronchopulmonary diseases]. 1975765599
[comparative characteristic of antibiotic activity of different aspergillus fumigatus strains]. 1975765689
variation in vivo and isolation of aspergillus fumigatus from a case of human aspergillosis. 1975765815
intravitreal effects of pimaricin in experimental fungal endophthalmitis.evaluation of 25, 50, and 100 mug of pimaricin given intravitreally to albino rabbits with aspergillus endophthalmitis revealed that 25 mug of pimaricin, while nontoxic to the retina, was ineffective in inhibiting the fungal process. a dose of 50 mug was significantly more effective in inhibiting fungal disease but also caused significant retinal damage with loss of retinal function and iridoplegia. dosages above this level resulted in vitreous retraction and degeneration, iridoplegia, and retin ...1976766638
immunologic monitoring and aspergillosis in renal transplant patients.three cases of pulmonary aspergillosis in a "high risk" population of renal transplant recipients are presented. the source of infection was traced to the forced air exhaust system of the transplantation unit. early definitive diagnosis of the infection was very important for effective management. immunologic monitoring was demonstrated to be instrumental in indicating the early presence of infection, and as a guideline to reduced immunosuppression during therapy. bronchoscopy with brushings and ...1976766657
[metabolic products of microorganisms. 150. ferricrocin, triacetylfusigen and other sideramines from fungi of the genus aspergillus, group fumigatus (author's transl)].the sideramines of 14 species of the genus aspergillus, group fumigatus, were isolated and analyzed. ferricrocin was identified in 11 extracts, ferrichrome in 2 others. a lipophilic sideramine produced by 4 species was identified as triacetylfusigen, another minor component as triacetylfusigen b. six species produced an alanine-containing sideramine, which may be identical with ferrichrom c.1975766717
sudden infant death syndrome in south australia. measurement of serum ige antibodies to three common allergens.radioallergosorbent test (rast) studies showed that ige antibodies to dermatophagoides pteronyssinus (house dust mite), aspergillus fumigatus and bovine beta-lactoglobulin were significantly elevated in the sera of infants who died as a result of the sudden death in infancy syndrome (sdis). no significant differences were found in the levels of total ige, iga, igg or igm in the sera of sdis victims or controls. the possible role of hypersensitivity in the aetiology of sdis is discussed.1975768723
hatchery problems--a field report.a long term investigational, advisory and monitoring exercise with a major hatchery emphasised the multi-disciplinary approach adopted by the agricultural development and advisory service (adas) to raise the performance of the many aspects of chick production. these included an investigation of egg handling techniques from nest box to hatcher; the adoption by the hatchery of plastic setter trays; an improvement to incubator environment; an improvement in the overall hatchery hygiene programme an ...1976769299
[experimental abortions in mice and guinea pigs caused by aspergillus fumigatus spores].experiments were carried out with a total of 82 laboratory animals including 56 mice and 26 guinea pigs. the possibility was tested to provoke abortions in them with the use of aspergillus fumigatus spores introduced through the trachea, orally or vaginally. the mould was isolated on chapek agar from an aborted bovine fetus. it was found that all three routes of infection lead to abortions setting in after three to five treatments on the 1st to 3rd day following the last introduction of spores. ...1976769306
mechanism of uptake of strontium isotopes in aspergillus lesions.observations on experimental aspergillosis of chorioallantoic membranes confirmed that strontium-85 uptake in aspergillus lesions was directly due to infection by the fungus. such uptake was not found in normal or in toxoplasma gondii-infected control membranes. further, the avidity of radionuclide uptake was proportional to the mycelial mass, as previously observed clinically. investigations on 85sr containing malt extract broth aspergillus fumigatus cultures revealed that fungal hyphas did not ...1976769615
conditional virulence of a p-aminobenzoic acid-requiring mutant of aspergillus fumigatus.the induced auxotrophy for p-aminobenzoic acid (paba) resulted in a complete loss of virulence of aspergillus fumigatus for normal as well as cortisone-treated mice. the paba-requiring mutant of a. fumigatus survived in vivo for 4 to 7 days without causing any infection. however, it showed conditional virulence in animals receiving paba in very small quantities. repeated inoculations of the viable spores of the avirulent mutant strain gave favorable results in building immunity against intraveno ...1976770331
skin reaction and macrophage migration inhibition tests for polysaccharides from aspergillus fumigatus and candida albicans.guinea pigs sensitized with purified galactomannan from aspergillus fumigatus and mannan from candida albicans, each containing negligible quantities of nitrogen, were examined for their immunological responses against the corresponding polysaccharides with respect to the delayed-type skin reaction and the macrophage migration inhibition phenomenon. in both cases, the delayed-type skin reaction test and the macrophage migration inhibition test showed positive results. the reactivity was stronger ...1975772255
morphogenesis and pathogenesis of chronic lung diseases. viii. cellularization of lung interlobular areas as a preliminary phase of peribronchovascular fibrosis.an experimental investigation of the lung interlobular areas was performed by elicitation of rabbits with antigens (aspergillar and human-serum proteins) administered in aerosols or intramuscularly in freund's adjuvant. the cell accumulations in the interlobular areas developed irrespective of the antigen, duration of exposure and route of administration. the cells accumulated (reticulo-lymphoid, plasma cells, eosinocytes) were counted and the areal surface measured. the total cell count and the ...1976772786
the relative susceptibility of new zealand black and cba mice to infection with opportunistic fungal pathogens.the susceptibility of ageing new zealand black (nzb) mice to infection with a number of opportunistic fungi and yeasts wsd compared with that of similarly aged mice of the cba strain. the nzb mice showed a greater susceptibility to lethal infection with aspergillus fumigatus, candida albicans and cryptococcus neoformans than did those of the cba strain. both mouse strains showed similar susceptibility to lethal infection by allescheria boydii, absidia corymbifera, mucor pusillus and rhizopus ory ...1976772839
pleural aspergillosis: a case report.the first case of pleural aspergillosis on either american continent since 1958 is reported. the recent literature is reviewed. the pleura is infected by aspergillus through bronchopleural or pleurocutaneous communication. surgical removal of aspergillus infected pleura is the cornerstone of therapy.1976773232
experimental aspergillosis and phycomycosis in mice. 1975773815
effect of cetylpyridinium chloride on pathogenic fungi and nocardia asteroides in sputum.the effect of cetylpyridinium chloride (cpc) on pathogenic fungi and nocardia asteroides was studied. sputa seeded with each of 11 organisms (aspergillus flavus; aspergillus fumigatus, blastomyces dermatitidis, candida albicans, coccidioides immitis, cryptococcus neoformans, geotrichum candidum, histoplasma capsulatum; nocardia asteroides, paracoccidioides brasiliensis, and sporothrix schenckii) were treated with cpc and kept for 2, 5 and 9 days. the cpc reagent used (0.5% cpc and 0.5% sodium ch ...1976773957
mycotic aneurysm of the thoracic aorta caused by aspergillus fumigatus.a 54-year-old diabetic patient had unexplained fever and embolic occlusion of the splenic, right renal, right hypogastric, right superficial femoral, and left popliteal arteries. aspergillus fumigatus was recovered from a femoral clot. an aortogram revealed a mycotic aneurysm of the thoracic aorta to be the source of the infected emboli. surgical excision of the aneurysm and therapy with amphotericin b were unsuccessful.1976776547
acquired immunity to aspergillus fumigatus.in mice preinfected with aspergillus fumigatus for greater than or equal to days, administration of cortisone failed to stimulate mycelial growth. the liver and heart of mice preinfected for 14 days resisted infection after a cortisone + conidia challenge.1976776836
proceedings: purification and characteristics of hemolytic toxin from aspergillus fumigatus. 1975778450
bronchopulmonary aspergillosis. an epidemiological study in a hospital population.in order to determine the incidence of bronchopulmonary aspergillosis in patients with other types of pulmonary pathology, 586 in-patients, out-patients and controls were examined during the period 1968-1970 in baguley hospital, manchester, england. it was found that from the 344 in-patients and out-patients with other pulmonary pathology, 6 had a definite diagnosis of allergic aspergillosis. 1 had pulmonary aspergilloma while 53 other patients demonstrated some evidence of bronchopulmonary aspe ...1976778964
cystine aminopeptidase (oxytocinase) activity in plasma and tissues of normal and infected pregnant cattle.cystine aminopeptidase (cap) activity in tissues and in plasma from pregnant cows was measured at various stages of gestation by using the substrate s-benzyl-l-cysteine-4-nitroanilide. the cap activity was as high or higher in hepatic and renal tissues as in cotyledonary tissue. plasma cap activity was low and did not change with length of gestation, nor did it change when placentation was disrupted by infection with aspergillus fumigatus.1976779545
[pathomorphology of pulmonary aspergillosis in tuberculosis patients based on according to resection material].to investigate various manifestations of broncho-pulmonary aspergillosis and to ascertain its association with a previous disease there were carried out histotopographic, histological and mycological studies of specimens of the lung tissue resected in 37 patients in connection with aspergillomas of the lungs and broncho-pulmonary aspergillosis. the investigations showed that aspergillosis was one of the forms of dysbacteriosis in the human organism and could develop against the background of pos ...1976779726
sources and incidence of airborne aspergillus fumigatus (fres).specific surveys of the air for aspergillus fumigatus were carried out in rural and urban situations over a 2-year period. overall, low concentrations of spores were recorded with a higher incidence during the "winter" months. counts in the open air and in a hospital ward showed similar fluctuations, the indoor counts being consistently lower. plant debris in the form of compost heaps and stacks of hay and straw baled with a high moisture content in which self-heating occurs, produces large numb ...1976780000
[effect of different ratios and concentrations of carbon and nitrogen in the medium on the growth and toxin formation of aspergillus fumigatus fres]. 1976781478
treatment of fungal sinusitis with autogenous vaccine. (a case report). 1976782005
[fluorescence immunologic studies of aspergillus fumigatus antibodies]. 1976782944
unusual mycotic findings in cytodiagnosis. 1976785916
ige antibodies in bronchopulmonary aspergillosis.total serum ige and serum ige antibodies to a. fumigatus were quantitated in 143 patients with different forms of bronchopulmonary aspergillosis. total serum ige levels were elevated in all patients with allergic bronchopulmonary aspergillosis but also in some other forms of bronchopulmonary aspergillosis, thus limiting the diagnostic value of total serum ige determination in this type of pulmonary mycotic infection. specific ige antibodies to a. fumigatus could be demonstrated in all patients w ...1976786083
intraocular effects of pimaricin.pigmented rabbits weighing 3 to 6 lbs were given bilateral intraocular injections of 250 to 1,000 mug pimaricin. following their injection, blood, aqueous and vitreous levels were determined at various time intervals during the first 24 hours and at 24 hour intervals thereafter for one week. in subsequent studies, pigmented rabbits were given bilateral intraocular injections of 5,000 spores of a. fumigatus and 30 hours later received intraocular injections of 250 to 1,000 mug pimaricin. these st ...1976786132
depletion of complement in vivo and in vitro by extracts of aspergillus fumigatus.a new, nontoxic material extracted from aspergillus fumigatus, is described with complement-depletion capacity both in vivo and in vitro. extracts of the mycelium of a. fumigatus were found to haemolyse sheep red blood cells, to be lethal for mice and to convert c3 into its faster electrophoretic form when incubated with normal human serum. conversion did not take place when purified c3 was used, suggesting that serum factors were required in the reaction. adsorption of the extracts with activat ...1976786901
an appraisal of impregon as a deterrent of domestic fungus growth.impregon brand of tetrachlorsalicylanilide (tcsa) has been profferred widely as a household fungistatic agent, although its value remains unproved. to assess its effects, this agent was used as a laundry and paint additive and as a treatment for burlap rug backing; after recommended applications of impregon, coded replicate materials were inoculated with mixed suspensions of fungus particles. no difference was evident in fungus growth points on fabric swatches washed in tap water with and withou ...1976787049
aspergillus prosthetic valve endocarditis.the clinical, laboratory, and histopathological features of seven cases of aspergillus fumigatus prosthetic valve endocarditis are presented. the exact nature of the lesion, a combination of infective fungal endocarditis and thrombosis on the prosthetic valve, is discussed and the difficulties in clinical diagnosis are emphasized. helpful indications were sudden unexplained heart failure with the appearance of new murmurs, and emboli to large or medium-sized systemic arteries. fever and anaemia ...1976788218
incidence of serum antibodies to several aspergillus species and to candida albicans in cystic fibrosis.the incidence of serum ige antibodies to several species of aspergillus and the incidence of serum precipitins to these species and to candida albicans were determined in 22 children with cystic fibrosis, 17 children with bronchial asthma, and 18 control subjects. ige antibodies were found in 50 per cent of the patients with cystic fibrosis and in 29 per cent of the patients with bronchial asthma; none was found in the control subjects. precipitins to aspergillus species were present in 59 per c ...1976788564
rast using crude and purified anti-ige.the sensitivity of the rast using anti-ige in 125i-labelled igg fractions of sheep antiserum was compared to that using anti-ige purified by immunosorbent techniques in tests with three allergens (grass pollens, aspergillus fumigatus and the detergent enzyme "alcalase") on sera from 248 workers in a detergent factory. both anti-ige reagents measure the same antibody but the rast procedure using the crude anti-ige reagent is less sensitive than that using the immunosorbent-purified anti-ige in it ...1976788951
combination amphotericin b-rifampin therapy for pulmonary aspergillosis in a leukemic patient.pulmonary aspergillosis developed in a 62-year-old man with acute myelogenous leukemia. therapy with amphotericin b and 5-fluorocytosine was begun. synergy between amphotericin b and rifampin was demonstrated in vitro, and therapy with firampin replaced 5-fluorocytosine. progressive clearing of the pulmonary lesion ensued, suggesting in vivo efficacy as well. further studies of patients utilizing this regimen are warranted.1976789031
salmonella and aspergillus infections in common loons overwintering in florida.during a 5-year period (1970-1975), 190 common loons (gavia immer) from overwintering populations on the east and west coasts of florida were examined for evidence of infectious diseases. salmonella spp (representing 8 serotypes) were isolated from 27 (14%) of the loons, and lesions typical of those produced by aspergillus fumigatus were found in 34 (18%) of the loons. seven loons were infected with salmonella spp and had lesions typical of aspergillus infection. the largest number of loons (124 ...1976789314
bilateral pulmonary aspergilloma in ankylosing spondylitis treated with transthoracic intracavitary instillations of antifungal agents.repeated transthoracic intracavitary injections of amphotericin b, nystatin and pimaricine proved a simple and safe method in the treatment of bilateral pulmonary aspergillomas in a patient with large cavities caused by lung disease in ankylosing spondylitis. both large mycetomas were dissolved by this treatment in combination with peroral corticosteroid medication, and the patient's general condition improved markedly.1976790560
direct fungal infection of the eye and its prevention. 1976791354
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