Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| [modeling of the sars coronavirus main proteinase and conformational flexibility of the active site]. | sars coronavirus 3cl proteinase is the key enzyme for virus replication which may serve as the target for drug discovery against sars. a 3d structure model has been built for sars coronavirus 3cl proteinase by comparative protein modeling. a homodimer model of the proteinase was also built. analysis of the dimeric interface suggests the 3cl proteinase may have dimer form in solution. the conformational flexibility of the active site has been simulated by molecular dynamics combined with multi-ca ... | 2003 | 12914221 |
| [immunoinformatic analysis for the epitopes on sars virus surface protein]. | sars virus is a recently found coronavirus, which cause human atypical pneumonia through the binding of its spike protein to the receptor on human cells. by using the methods of immunoinformatics, we analyzed the virus surface protein and found that the epitopes, which can be recognized by human immune system, are strikingly changed or disappeared to compare with other common human coronavirus. this result may imply that the escape of sars virus from human immune surveillance may be the causalit ... | 2003 | 12914223 |
| a novel coronavirus and sars. | 2003 | 12917313 | |
| the severe acute respiratory syndrome (sars) coronavirus ntpase/helicase belongs to a distinct class of 5' to 3' viral helicases. | the putative ntpase/helicase protein from severe acute respiratory syndrome coronavirus (sars-cov) is postulated to play a number of crucial roles in the viral life cycle, making it an attractive target for anti-sars therapy. we have cloned, expressed, and purified this protein as an n-terminal hexahistidine fusion in escherichia coli and have characterized its helicase and ntpase activities. the enzyme unwinds double-stranded dna, dependent on the presence of a 5' single-stranded overhang, indi ... | 2003 | 12917423 |
| mechanisms and enzymes involved in sars coronavirus genome expression. | a novel coronavirus is the causative agent of the current epidemic of severe acute respiratory syndrome (sars). coronaviruses are exceptionally large rna viruses and employ complex regulatory mechanisms to express their genomes. here, we determined the sequence of sars coronavirus (sars-cov), isolate frankfurt 1, and characterized key rna elements and protein functions involved in viral genome expression. important regulatory mechanisms, such as the (discontinuous) synthesis of eight subgenomic ... | 2003 | 12917450 |
| [detection of cell apoptosis in the pathological tissues of patients with sars and its significance]. | to explore the role and mechanism of apoptosis in severe acute respiratory syndrome (sars). | 2003 | 12919893 |
| structural genomics of the sars coronavirus: cloning, expression, crystallization and preliminary crystallographic study of the nsp9 protein. | the aetiologic agent of the recent epidemics of severe acute respiratory syndrome (sars) is a positive-stranded rna virus (sars-cov) belonging to the coronaviridae family and its genome differs substantially from those of other known coronaviruses. sars-cov is transmissible mainly by the respiratory route and to date there is no vaccine and no prophylactic or therapeutic treatments against this agent. a sars-cov whole-genome approach has been developed aimed at determining the crystal structure ... | 2003 | 12925794 |
| unique and conserved features of genome and proteome of sars-coronavirus, an early split-off from the coronavirus group 2 lineage. | the genome organization and expression strategy of the newly identified severe acute respiratory syndrome coronavirus (sars-cov) were predicted using recently published genome sequences. fourteen putative open reading frames were identified, 12 of which were predicted to be expressed from a nested set of eight subgenomic mrnas. the synthesis of these mrnas in sars-cov-infected cells was confirmed experimentally. the 4382- and 7073 amino acid residue sars-cov replicase polyproteins are predicted ... | 2003 | 12927536 |
| coronavirus in severe acute respiratory syndrome (sars). | 2003 | 12928031 | |
| severe acute respiratory syndrome: identification of the etiological agent. | 2003 | 12928032 | |
| [basically sars is not a surprise. coronaviruses lie in wait almost everywhere]. | 2003 | 12929325 | |
| possible role of an animal vector in the sars outbreak at amoy gardens. | a mass outbreak of severe acute respiratory syndrome (sars) in the amoy gardens housing complex in hong kong at the end of march, 2003, affected more than 300 residents in less than a month, and has epidemiologists all over the world puzzled about the mode of transmission of this new disease, which until then was thought to be transmitted solely by respiratory droplets. the source of the outbreak was later traced to an individual with sars who spent two nights at amoy gardens. official explanati ... | 2003 | 12932393 |
| questions about comparative genomics of sars coronavirus isolates. | 2003 | 12932399 | |
| infectious diseases. civets back on china's menu. | 2003 | 12933984 | |
| inhibiting severe acute respiratory syndrome-associated coronavirus by small interfering rna. | to evaluate the effectiveness of small interfering rna (sirna) on inhibiting severe acute respiratory syndrome (sars)-associated coronavirus replication, and to lay bases for the future clinical application of sirna for the treatment of viral infectious diseases. | 2003 | 12935424 |
| christopher columbus, king canute and sars: the name does matter. | 2003 | 12938762 | |
| [initial analysis of complete genome sequences of sars coronavirus]. | multiple sequence alignment among 12 complete sars coronavirus (sars-cov) sequences reveals that the major parts of 29708 b of the genomes have 99.82% identical bases. forty two nucleotide mismatches were found in addition to the five and six gaps in two genomes. among them, 28 mismatches result in changes of amino acid in the encoded proteins. analysis of the changes implies possible effect on the spike and membrane protein of the virus, while most of the other changes seem not very significant ... | 2003 | 12939792 |
| [genomic characterization of sars coronavirus: a novel member of coronavirus]. | in march 2003, sars-cov, a novel coronavirus which has been proved to be a pathogen causing severe acute respiratory syndrome (sars). the complete genome of sars-cov has been sequenced by international collaboration including china. in the present study, the genome sequences were collected from ncbi and genomic characterization was analyzed. sars-cov has a genome of 28-30 kb including 11 orfs (open reading frames), which is consistent with that of coronavirus family, and its genome organization ... | 2003 | 12939793 |
| severe acute respiratory syndrome--novel virus, recurring theme. | 2003 | 12939884 | |
| sars wars: family physicians undeployed soldiers. | 2003 | 12943351 | |
| sars coronavirus-infected cells in lung detected by new in situ hybridization technique. | 2003 | 12944688 | |
| quest for sars source gathers pace in bid to thwart resurgence. | 2003 | 12944926 | |
| severe acute respiratory syndrome--a new coronavirus from the chinese dragon's lair. | the recent identification of a novel clinical entity, the severe acute respiratory syndrome (sars), the rapid subsequent spread and case fatality rates of 14-15% have prompted a massive international collaborative investigation facilitated by a network of laboratories established by the world health organization (who). as sars has the potential of becoming the first pandemic of the new millennium, a global warning by the who was issued on 12 march 2003. the disease, which is believed to have its ... | 2003 | 12950672 |
| severe acute respiratory syndrome (sars). | 2003 | 12952008 | |
| [severe acute respiratory syndrome (sars)]. | severe acute respiratory syndrome (sars) is a disease caused by a corona-virus. these viruses are long known to be human pathogens but this form is new and more virulent. it emerged in march this year in china and seemed to be apt to sweep over the world as a kind of spanish flu. forunately, this didn't happen and at the moment the emerging pandemic seems to be contained. this offers hope in case a more virulent pandemic would suddenly strike in the next future. a world prepared is a difficult p ... | 2003 | 12953388 |
| sars. another emerging disease. | 2003 | 12955949 | |
| infectious diseases. sars experts in china urge wider animal testing. | 2003 | 12958334 | |
| isolation and characterization of viruses related to the sars coronavirus from animals in southern china. | a novel coronavirus (scov) is the etiological agent of severe acute respiratory syndrome (sars). scov-like viruses were isolated from himalayan palm civets found in a live-animal market in guangdong, china. evidence of virus infection was also detected in other animals (including a raccoon dog, nyctereutes procyonoides) and in humans working at the same market. all the animal isolates retain a 29-nucleotide sequence that is not found in most human isolates. the detection of scov-like viruses in ... | 2003 | 12958366 |
| isolation and characterization of viruses related to the sars coronavirus from animals in southern china. | a novel coronavirus (scov) is the etiological agent of severe acute respiratory syndrome (sars). scov-like viruses were isolated from himalayan palm civets found in a live-animal market in guangdong, china. evidence of virus infection was also detected in other animals (including a raccoon dog, nyctereutes procyonoides) and in humans working at the same market. all the animal isolates retain a 29-nucleotide sequence that is not found in most human isolates. the detection of scov-like viruses in ... | 2003 | 12958366 |
| does sars coronavirus originate from animals? | 2003 | 12959142 | |
| [sars. a lesson in infection epidemiology and a masterpiece of modern infection control]. | 2003 | 12961021 | |
| canadian officials watch sars-like mystery bug. | 2003 | 12962110 | |
| a double epidemic model for the sars propagation. | an epidemic of a severe acute respiratory syndrome (sars) caused by a new coronavirus has spread from the guangdong province to the rest of china and to the world, with a puzzling contagion behavior. it is important both for predicting the future of the present outbreak and for implementing effective prophylactic measures, to identify the causes of this behavior. | 2003 | 12964944 |
| early events of sars coronavirus infection in vero cells. | an isolate from a patient in the recent severe acute respiratory syndrome (sars) outbreak in singapore was used to infect vero e6 cells. this study concentrated on the first 30 min of infection. it was discovered that the sars coronavirus attached, entered, and uncoated the nucleocapsids, all within a 30-min period. at 5 min after infection, several virus particles lined the vero cell plasma membrane. virus particles were at various stages of fusion at the cell surface, since entry was not a syn ... | 2003 | 12966536 |
| 7 steps to submit suspicious samples for sars testing. | 2003 | 12966839 | |
| the timing of the 5th congress of the asian pacific federation of societies for surgery of the hand (apfssh). | 2003 | 12966931 | |
| fatal outcome of sars in a patient with reactivation of chronic hepatitis b. | 2003 | 12967706 | |
| association of hla class i with severe acute respiratory syndrome coronavirus infection. | the human leukocyte antigen (hla) system is widely used as a strategy in the search for the etiology of infectious diseases and autoimmune disorders. during the taiwan epidemic of severe acute respiratory syndrome (sars), many health care workers were infected. in an effort to establish a screening program for high risk personal, the distribution of hla class i and ii alleles in case and control groups was examined for the presence of an association to a genetic susceptibly or resistance to sars ... | 2003 | 12969506 |
| asymptomatic animal traders prove positive for sars virus. | 2003 | 12969920 | |
| [genome analysis of the sars-associated virus]. | 2003 | 12970946 | |
| the threat of severe acute respiratory syndrome (sars). | severe acute respiratory syndrome (sars) is a recently recognized infectious disease associated with severe morbidity and mortality. it presents with non-specific signs and symptoms and because no definitive laboratory test is readily available, it poses a great risk to healthcare workers as well as difficulty in quarantine. the global response has been coordinated and enthusiastic in trying to understand and control this disease. severe acute respiratory syndrome poses a threat to the caribbean ... | 2003 | 12974057 |
| [preliminary result on the nosocomial infection of severe acute respiratory syndrome in one hospital of beijing]. | to study the transmission route of severe acute respiratory syndrome (sars) nosocomial infection. | 2003 | 12975006 |
| severe acute respiratory syndrome in haemodialysis patients: a report of two cases. | 2003 | 13679500 | |
| cloaked similarity between hiv-1 and sars-cov suggests an anti-sars strategy. | severe acute respiratory syndrome (sars) is a febrile respiratory illness. the disease has been etiologically linked to a novel coronavirus that has been named the sars-associated coronavirus (sars-cov), whose genome was recently sequenced. since it is a member of the coronaviridae, its spike protein (s2) is believed to play a central role in viral entry by facilitating fusion between the viral and host cell membranes. the protein responsible for viral-induced membrane fusion of hiv-1 (gp41) dif ... | 2003 | 14499001 |
| relationship of sars-cov to other pathogenic rna viruses explored by tetranucleotide usage profiling. | the exact origin of the cause of the severe acute respiratory syndrome (sars) is still an open question. the genomic sequence relationship of sars-cov with 30 different single-stranded rna (ssrna) viruses of various families was studied using two non-standard approaches. both approaches began with the vectorial profiling of the tetra-nucleotide usage pattern v for each virus. in approach one, a distance measure of a vector v, based on correlation coefficient was devised to construct a relationsh ... | 2003 | 14499005 |
| sars--unprecedented global response to a newly emerging disease. | 2003 | 14503787 | |
| how the sars vaccine effort can learn from hiv-speeding towards the future, learning from the past. | a remarkable collaborative effort coordinated by the severe acute respiratory syndrome (sars) team at who resulted in discovery of the etiologic agent of severe acute respiratory syndrome less than 2 months after the announcement of global alert. the development of a vaccine to prevent sars should be pursued with the same urgency and cooperative spirit, as sars is highly lethal and, if not controlled during the first few generations of transmission, is likely to become endemic in regions of the ... | 2003 | 14505885 |
| lung pathology of severe acute respiratory syndrome (sars): a study of 8 autopsy cases from singapore. | severe acute respiratory syndrome (sars) is an infectious condition caused by the sars-associated coronavirus (sars-cov), a new member in the family coronaviridae. to evaluate the lung pathology in this life-threatening respiratory illness, we studied postmortem lung sections from 8 patients who died from sars during the spring 2003 singapore outbreak. the predominant pattern of lung injury in all 8 cases was diffuse alveolar damage. the histology varied according to the duration of illness. cas ... | 2003 | 14506633 |
| severe acute respiratory syndrome treatment: present status and future strategy. | 2003 | 14508874 | |
| molecular modelling of s1 and s2 subunits of sars coronavirus spike glycoprotein. | the s1 and s2 subunits of the spike glycoprotein of the coronavirus which is responsible for the severe acute respiratory syndrome (sars) have been modelled, even though the corresponding amino acid sequences were not suitable for tertiary structure predictions with conventional homology and/or threading procedures. an indirect search for a protein structure to be used as a template for 3d modelling has been performed on the basis of the genomic organisation similarity generally exhibited by cor ... | 2003 | 14511651 |
| f.d.a. asks if a genetic test is sold without approval. | 2003 | 14515843 | |
| enteric involvement of severe acute respiratory syndrome-associated coronavirus infection. | severe acute respiratory syndrome (sars) is a recently emerged infection from a novel coronavirus (cov). apart from fever and respiratory complications, gastrointestinal symptoms are frequently observed in patients with sars but the significance remains undetermined. herein, we describe the clinical, pathologic, and virologic features of the intestinal involvement of this new viral infection. | 2003 | 14517783 |
| [israeli guidelines for investigation and management of sars cases and their contacts]. | as the first emerging epidemic of the 21st century, sars has raised much interest and fear among statesmen, economists, and the general public, as well as within the medical community. this new disease is characterized by several daunting challenges, including person-to-person transmission, an environmentally resistant agent, a non-specific clinical presentation, and a high fatality rate among high risk individuals. in israel, as elsewhere, public health authorities were forced to quickly design ... | 2003 | 14518156 |
| role of china in the quest to define and control severe acute respiratory syndrome. | china holds the key to solving many questions crucial to global control of severe acute respiratory syndrome (sars). the disease appears to have originated in guangdong province, and the causative agent, sars coronavirus, is likely to have originated from an animal host, perhaps sold in public markets. epidemiologic findings, integral to defining an animal-human linkage, may be confirmed by laboratory studies; once animal host (s) are confirmed, interventions may be needed to prevent further ani ... | 2003 | 14519236 |
| microbiologic characteristics, serologic responses, and clinical manifestations in severe acute respiratory syndrome, taiwan. | the genome of one taiwanese severe acute respiratory syndrome-associated coronavirus (sars-cov) strain (tw1) was 29,729 nt in length. viral rna may persist for some time in patients who seroconvert, and some patients may lack an antibody response (immunoglobulin g) to sars-cov <21 days after illness onset. an upsurge of antibody response was associated with the aggravation of respiratory failure. | 2003 | 14519257 |
| [clinical analysis of pregnancy in second and third trimesters complicated severe acute respiratory syndrome]. | to explore and analyze the clinical manifestation, diagnosis, management and maternal-perinatal prognosis of severe acute respiratory syndrome (sars)-complicated pregnancy in second and third trimesters. | 2003 | 14521763 |
| early diagnosis of sars coronavirus infection by real time rt-pcr. | a novel coronavirus was recently identified as the aetiological agent of severe acute respiratory syndrome (sars). molecular assays currently available for detection of sars-coronavirus (sars-cov) have low sensitivity during the early stage of the illness. | 2003 | 14522060 |
| sars-coronavirus replicates in mononuclear cells of peripheral blood (pbmcs) from sars patients. | the etiologic agent of severe acute respiratory syndrome (sars) is a recently identified, positive single-stranded rna (ssrna) coronavirus (sars-cov). little is known about the dynamic changes of the viral replicative form in sars cases. | 2003 | 14522061 |
| severe acute respiratory syndrome (sars). | 2003 | 14522062 | |
| sars associated coronavirus has a recombinant polymerase and coronaviruses have a history of host-shifting. | the sudden appearance and potential lethality of severe acute respiratory syndrome associated coronavirus (sars-cov) in humans has focused attention on understanding its origins. here, we assess phylogenetic relationships for the sars-cov lineage as well as the history of host-species shifts for sars-cov and other coronaviruses. we used a bayesian phylogenetic inference approach with sliding window analyses of three sars-cov proteins: rna dependent rna polymerase (rdrp), nucleocapsid (n) and spi ... | 2003 | 14522185 |
| infants born to mothers with severe acute respiratory syndrome. | severe acute respiratory syndrome (sars) is a newly discovered infectious disease caused by a novel coronavirus. during the community outbreak in hong kong, 5 liveborn infants were born to pregnant women with sars. a systematic search for perinatal transmission of the sars-associated coronavirus, including serial reverse transcriptase-polymerase chain reaction assays, viral cultures, and paired serologic titers, failed to detect the virus in any of the infants. in addition, none of the infants d ... | 2003 | 14523207 |
| children hospitalized with severe acute respiratory syndrome-related illness in toronto. | an outbreak of severe acute respiratory syndrome (sars) occurred in the greater toronto area between february and june 2003. we describe the clinical, laboratory, and epidemiologic features of children who were admitted to the hospital for sick children, toronto, with a presumptive diagnosis of suspect or probable sars. | 2003 | 14523209 |
| infectious diseases. sars experts want labs to improve safety practices. | 2003 | 14526044 | |
| sars, wildlife, and human health. | 2003 | 14526058 | |
| de novo synthesis of pcr templates for the development of sars diagnostic assay. | a novel coronavirus was identified as the cause for severe acute respiratory syndrome (sars). the complete sequence of sars genome has provided an opportunity for the development of molecular diagnostic assays. to restrain further outbreak of sars, the world health organization has posted several pairs of polymerase chain reaction (pcr) primers for early diagnosis and urged more research to be done on pcr protocols. here we report a strategy for the de novo synthesis of pcr templates complimenta ... | 2003 | 14526121 |
| dynamic changes in blood cytokine levels as clinical indicators in severe acute respiratory syndrome. | to investigate the dynamic changes observed in serum levels of interleukins (ils), tumor necrosis factor-alpha (tnf-alpha) and transforming growth factor-beta1 (tgf-beta1) in severe acute respiratory syndrome (sars) patients. | 2003 | 14527349 |
| severe acute respiratory syndrome-associated coronavirus genotype and its characterization. | to study the severe acute respiratory syndrome (sars)-associated coronavirus genotype and its characteristics. | 2003 | 14527350 |
| fierce creatures. zoonoses, diseases that jump from animals to humans, are a growing health problem around the world. understanding their causes and their effects on humans have therefore become an important topic for global public health. | 2003 | 14528257 | |
| [severe acute respiratory syndrome--sars]. | severe acute respiratory syndrome (sars) is an acute respiratory illness caused by sars coronavirus. this virus was possibly transmitted from an animal reservoir to humans, and from february 2003, the epidemic was spread internationally by further person-to-person transmission. the sars epidemic was managed by well-known principles of infection control, including prompt diagnosis, isolation of patients, and quarantine of contacts. the successful control of the outbreak is a remarkable internatio ... | 2003 | 14531368 |
| mild severe acute respiratory syndrome. | 2003 | 14531381 | |
| transmission of severe acute respiratory syndrome. | 2003 | 14531382 | |
| putative caveolin-binding sites in sars-cov proteins. | to obtain the information of protein-protein interaction between the sars-cov proteins and caveolin-1, identify the possible caveolin-binding sites in sars-cov proteins. | 2003 | 14531951 |
| evaluation of reverse transcription-pcr assays for rapid diagnosis of severe acute respiratory syndrome associated with a novel coronavirus. | the reverse transcription (rt)-pcr protocols of two world health organization (who) severe acute respiratory syndrome (sars) network laboratories (who sars network laboratories at the university of hong kong [who-hku] and at the bernhard-nocht institute in hamburg, germany [who-hamburg]) were evaluated for rapid diagnosis of a novel coronavirus (cov) associated with sars in hong kong. a total of 303 clinical specimens were collected from 163 patients suspected to have sars. the end point of both ... | 2003 | 14532176 |
| treatment of sars with human interferons. | 2003 | 14550714 | |
| treatment of sars with human interferons. | 2003 | 14550718 | |
| infectious diseases. sars researchers report new animal models. | 2003 | 14551412 | |
| sars and the dental professional. | 2003 | 14552214 | |
| sars and saarc: lessons for preparedness. | 2003 | 14552237 | |
| [dynamic observation igg and igm antibodies in patients with severe acute respiratory syndrome]. | to observe igg and igm antibodies in patients with severe acute respiratory syndrome (sars) and to explore their significance. | 2003 | 14552674 |
| [analysis and causation discussion of 185 severe acute respiratory syndrome dead cases]. | to proceed the retrospective analysis of the dead reasons of patients with severe acute respiratory syndrome (sars), in order to provide experience for decreasing mortality of sars patients in clinic. | 2003 | 14552675 |
| is it flu or sars? mds gear up for a difficult winter. | 2003 | 14557327 | |
| new sars recommendations to be released this month. | 2003 | 14557328 | |
| canada's approach to public health must be reinvented: sars report. | 2003 | 14557334 | |
| [detection and analysis of sars coronavirus-specific antibodies in sera from non-sars children]. | to examine the presence of severe acute respiratory syndrome (sars) coronavirus-specific antibodies in the sera from non-sars children. | 2003 | 14559701 |
| biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3c-like proteinase. | the 3c-like proteinase of severe acute respiratory syndrome (sars) coronavirus has been proposed to be a key target for structural-based drug design against sars. in order to understand the active form and the substrate specificity of the enzyme, we have cloned, expressed, and purified sars 3c-like proteinase. analytic gel filtration shows a mixture of monomer and dimer at a protein concentration of 4 mg/ml and mostly monomer at 0.2 mg/ml, which correspond to the concentration used in the enzyme ... | 2004 | 14561748 |
| prevalence of igg antibody to sars-associated coronavirus in animal traders--guangdong province, china, 2003. | severe acute respiratory syndrome (sars) was identified in 2003 as an infectious disease caused by the sars-associated coronavirus (sars-cov), a member of the coronavirus family not observed previously in humans. because its sequence data differ from that of known human coronaviruses, sars-cov is suspected to have crossed the species barrier between an animal host and humans. the sars outbreak began in china's guangdong province, where approximately 1,500 probable cases were identified during no ... | 2003 | 14561956 |
| prevalence of igg antibody to sars-associated coronavirus in animal traders--guangdong province, china, 2003. | severe acute respiratory syndrome (sars) was identified in 2003 as an infectious disease caused by the sars-associated coronavirus (sars-cov), a member of the coronavirus family not observed previously in humans. because its sequence data differ from that of known human coronaviruses, sars-cov is suspected to have crossed the species barrier between an animal host and humans. the sars outbreak began in china's guangdong province, where approximately 1,500 probable cases were identified during no ... | 2003 | 14561956 |
| [isolation and identification of the infective agent of severe acute respiratory syndrome (sars) from a patient with atypical pneumonia]. | the virological, morphological, molecular biological and immunochemical study of the infective agent isolated from the patient with the symptoms of atypical pneumonia, hospitalized in the infectious department of the clinical hospital in blagoveshchensk, was carried out. thus the fact of the appearance of sars virus on the territory of russia was proved. the isolated infective agent, identified as coronavirus strain cod, was partly characterized and deposited to the virus collection of the cente ... | 2003 | 14565137 |
| reverse genetics with a full-length infectious cdna of severe acute respiratory syndrome coronavirus. | a previously undescribed coronavirus (cov) is the etiologic agent responsible for severe acute respiratory syndrome (sars). using a panel of contiguous cdnas that span the entire genome, we have assembled a full-length cdna of the sars-cov urbani strain, and have rescued molecularly cloned sars viruses (infectious clone sars-cov) that contained the expected marker mutations inserted into the component clones. recombinant viruses replicated as efficiently as wt virus and both were inhibited by tr ... | 2003 | 14569023 |
| report details lessons from sars outbreak. | 2003 | 14570038 | |
| studies explore impact of new pathogens: investigators report on metapneumovirus, sars. | 2003 | 14570932 | |
| prediction of proteinase cleavage sites in polyproteins of coronaviruses and its applications in analyzing sars-cov genomes. | recently, we have developed a coronavirus-specific gene-finding system, zcurve_cov 1.0. in this paper, the system is further improved by taking the prediction of cleavage sites of viral proteinases in polyproteins into account. the cleavage sites of the 3c-like proteinase and papain-like proteinase are highly conserved. based on the method of traditional positional weight matrix trained by the peptides around cleavage sites, the present method also sufficiently considers the length conservation ... | 2003 | 14572668 |
| [analysis of false-positive associated with antibody tests for sars-cov in sle patients]. | to discuss the false-positive of serological diagnostic testing for coronavirus antibody in patients with systemic lupus erythematosus(sle), 66 normal individual and 31 sle with non-sars patients were detected for sars-associated coronavirus (sars-cov) antibody and rna by enzymelinked immunosorbent assays(elisa) and reverse transcriptase-polymerase chain reaction(rt-pcr). the result showed 2/66 cases(3.0%) were positive of sars-cov-igg antibody and 66 cases were negative of sars-cov-igm antibody ... | 2003 | 14574997 |
| [detection of the anti-sars-coronavirus specific antibody levels in 156 sars patients]. | the objective of this study was to explore the development of igg and igm against sars cov and characteristics of changes of antibody titers in patients with severe acute respiratory syndrome (sars) and to search the opportunity for collecting specific anti-serum from convalescent patients with sars. the anti-sars-coronavirus specific antibody levels in 156 sars patients were measured with elisa. the results showed that the total positive rates of igg and igm were 75.6% and 41.7% respectively, a ... | 2003 | 14575532 |
| [public health and severe acute respiratory syndrome]. | 2003 | 14576858 | |
| how sars changed the world in less than six months. | 2003 | 14576896 | |
| [genomic variations in the locus for aminopeptidase n:a putative cellular receptor for sars-cov spike glycoprotein]. | aminopeptidase n has been identified as the cellular receptor for human coronavirus hcov-229e and was a putative receptor for the spike glycoprotein encoded by the sars-associated coronavirus (sars-cov). we report here identification of 9 single nucleotide polymorphisms (snps) in anpep, encoding human aminopeptidase n, in chinese. all anpep exons and their flanking intronic sequences were amplified from unrelated normal individuals by polymerase chain reaction (pcr) and screened using denaturing ... | 2003 | 14579541 |
| epidemiology and cause of severe acute respiratory syndrome (sars) in guangdong, people's republic of china, in february, 2003. | an epidemic of severe acute respiratory syndrome (sars) has been associated with an outbreak of atypical pneumonia originating in guangdong province, people's republic of china. we aimed to identify the causative agent in the guangdong outbreak and describe the emergence and spread of the disease within the province. | 2003 | 14585636 |
| the crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. | a newly identified severe acute respiratory syndrome coronavirus (sars-cov), is the etiological agent responsible for the outbreak of sars. the sars-cov main protease, which is a 33.8-kda protease (also called the 3c-like protease), plays a pivotal role in mediating viral replication and transcription functions through extensive proteolytic processing of two replicase polyproteins, pp1a (486 kda) and pp1ab (790 kda). here, we report the crystal structures of the sars-cov main protease at differe ... | 2003 | 14585926 |
| virology: sars virus infection of cats and ferrets. | 2003 | 14586458 |