Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| asiatic acid, a pentacyclic triterpene from centella asiatica, is neuroprotective in a mouse model of focal cerebral ischemia. | asiatic acid, a triterpenoid derivative from centella asiatica, has shown biological effects such as antioxidant, antiinflammatory, and protection against glutamate- or beta-amyloid-induced neurotoxicity. we investigated the neuroprotective effect of asiatic acid in a mouse model of permanent cerebral ischemia. various doses of asiatic acid (30, 75, or 165 mg/kg) were administered orally at 1 hr pre- and 3, 10, and 20 hr postischemia, and infarct volume and behavioral deficits were evaluated at ... | 2009 | 19382233 |
| a new herbal combination, etana, for enhancing erectile function: an efficacy and safety study in animals. | we present herein a new herbal combination called etana that is composed of five herbal extracts including panax quinquelotius (ginseng), eurycoma longifolia (tongkat ali), epimedium grandiflorum (horny goat weed), centella asiatica (gotu kola) and flower pollen extracts. most of the above-mentioned extracts have a long historical and traditional use for erectile dysfunction (ed). on the basis of the mechanism of action of each of the above, a combination is introduced to overcome several physio ... | 2009 | 19494825 |
| protection of dna and membranes from gamma-radiation induced damages by centella asiatica. | the objective of the present study was to examine the ability of centella asiatica extract to offer protection to dna and membranes against the deleterious effects of ionizing radiation exposure. | 2009 | 19589237 |
| asiatic acid induces colon cancer cell growth inhibition and apoptosis through mitochondrial death cascade. | cancer is one of the leading causes of death in the world. the triterpenoid compound asiatic acid derived from the tropical medicinal plant centella asiatica displays cytotoxic activity on fibroblast cells and several other kinds of cells. the present work studies asiatic acid-mediated growth inhibition of cancer cells and the underlying mechanism. asiatic acid markedly inhibited cancer cell proliferation. apoptosis of sw480 human colon cancer cells was induced by asiatic acid as shown by flow c ... | 2009 | 19652380 |
| anti-inflammatory effects of madecassic acid via the suppression of nf-kappab pathway in lps-induced raw 264.7 macrophage cells. | we have investigated the anti-inflammatory effects of madecassic acid and madecassoside isolated from centella asiatica (umbelliferae) on lipopolysaccharide (lps)-stimulated raw 264.7 murine macrophage cells. both madecassic acid and madecassoside inhibited the production of nitric oxide (no), prostaglandin e(2) (pge(2)), tumor necrosis factor-alpha (tnf-alpha), interleukin-1 beta (il-1beta), and il-6. however, madecassic acid more potently suppressed these inflammatory mediators than did madeca ... | 2010 | 19774506 |
| characterization of a dammarenediol synthase in centella asiatica (l.) urban. | to elucidate the exact function of cabas in centella asiatica, which was previously reported as a putative beta-amyrin synthase [plant cell rep, 24:304-311, 2005], this gene was functionally expressed in the lanosterol synthase-deficient yeast mutant (erg7). after inducing the cabas gene with galactose, a peak consistent with the dammarenediol standard was detected in lc/apcims analyses and the accumulated product was confirmed as dammarenediol. cabas should therefore be renamed to c. asiatica d ... | 2009 | 19796960 |
| adulticidal and larvicidal efficacy of some medicinal plant extracts against tick, fluke and mosquitoes. | the adulticidal and larvicidal effect of indigenous plant extracts were investigated against the adult cattle tick haemaphysalis bispinosa neumann, 1897 (acarina: ixodidae), sheep fluke paramphistomum cervi zeder, 1790 (digenea: paramphistomatidae), fourth instar larvae of malaria vector, anopheles subpictus grassi and japanese encephalitis vector, culex tritaeniorhynchus giles (diptera: culicidae). the aim of this study was to evaluate the toxic effect of leaf hexane, chloroform, ethyl acetate, ... | 2009 | 19819626 |
| conversion of alpha-amyrin into centellosides by plant cell cultures of centella asiatica. | plant cell cultures of centella asiatica produce small quantities of centellosides: madecassosid > asiaticosid > madecassic acid > asiatic acid. to obtain a more efficient production system of these bioactive triterpenoid compounds, we developed a process where the substrate, alpha-amyrin, was converted into centellosides by cell suspensions of c. asiatica. when alpha-amyrin in acetone was added at 0.01 mg/ml(-1) to the culture medium, together with the permeabilizing agent dmso, after 7 days ne ... | 2010 | 19838635 |
| antioxidant and cytotoxic activities of centella asiatica (l) urb. | in the present study, the phenolic (folin-dennis) and flavonoid (colorimetric assay) constituents, antioxidant [2,2-diphenyl-2-picrylhydrazyl hydrate (dpph) assay] and cytotoxic activities of an aqueous extract (ae) of centella asiatica leaves were investigated. the aqueous extract (50 g/l) was obtained by infusion followed by cold maceration for 24 h. the levels of phenolic and flavonoid compounds were 2.86 g/100 g and 0.361 g/100 g, respectively. the ae showed elevated dpph scavenging activity ... | 2009 | 19865514 |
| centella asiatica improves physical performance and health-related quality of life in healthy elderly volunteer. | recently, oxidative stress has been reported to contribute an important role in the decline of physical function as age advances. numerous antioxidants can improve both physical and psychological performances resulting in the increase of health-related quality of life (hqol). therefore, we hypothesized that centella asiatica, a medicinal plant reputed for nerve tonic, strength improvement and antioxidant activity, could improve the physical performance and hqol especially in the physical satisfa ... | 2011 | 19880441 |
| 3,5-dicaffeoyl-4-malonylquinic acid reduced oxidative stress and inflammation in a experimental model of inflammatory bowel disease. | the aim of the present study was to examine the effects of 3,5-dicaffeoyl-4-malonylquinic acid (ca1), extract from centella asiatica, in rats subjected to experimental colitis. | 2010 | 19886745 |
| pentacyclic triterpenoids from the medicinal herb, centella asiatica (l.) urban. | centella asiatica accumulates large quantities of pentacyclic triterpenoid saponins, collectively known as centelloids. these terpenoids include asiaticoside, centelloside, madecassoside, brahmoside, brahminoside, thankuniside, sceffoleoside, centellose, asiatic-, brahmic-, centellic- and madecassic acids. the triterpene saponins are common secondary plant metabolites and are synthesized via the isoprenoid pathway to produce a hydrophobic triterpenoid structure (aglycone) containing a hydrophili ... | 2009 | 19924039 |
| prophylaxis with centella asiatica confers protection to prepubertal mice against 3-nitropropionic-acid-induced oxidative stress in brain. | while the usage of centella asiatica (ca) is on the increase worldwide, evidence demonstrating its protective efficacy against neurotoxicants is scarce. hence the present study aimed to understand the neuroprotective efficacy of a standardized aqueous extract of ca against 3-nitropropionic-acid(3-npa)-induced oxidative stress in the brain of prepubertal mice. we assessed the degree of oxidative stress in cytoplasm of brain regions of male mice (4 wk- old) given ca prophylaxis (5 mg/kg bw) for 10 ... | 2010 | 19943239 |
| study and description of hydrogels and organogels as vehicles for cosmetic active ingredients. | cellulite, a clinical syndrome mainly affecting women, involves specific changes in conjunctive dermic and subcutaneous tissue, leading to vascular and hypertrophic alterations in adipose tissues and the consequent alteration of tissue structure. this paper describes the design of hydrogels and pluronic-lecithin organogels elaborated as vehicles of aloe vera (aloe vera linné) and hydrocotyle asiatica (centella asiatica) for the treatment of cellulite. the objective of this work was to carry out ... | 2010 | 20038351 |
| [multicentric study on a topical compound with lymph-draining action in the treatment of the phlebostatic ulcer of the inferior limbs]. | phlebostatic sore of the lower limbs is a typical chronic venous insufficiency complication and is still a widely controversial issue in its treatment. the common therapies, in fact, are not yet standardized and they not show complete efficacy. since 2005 to 2007 a multicentric clinical trial was conducted at the plastic and reconstructive surgery of "sapienza" university of rome and at the plastic and reconstructive surgery department, university of perugia, in order to evaluate the efficacy of ... | 2010 | 20109380 |
| neuroprotective effect of centella asiatica extract (cae) on experimentally induced parkinsonism in aged sprague-dawley rats. | reactive oxygen species (ros) play an important role in ageing and age-related neurodegenerative changes including parkinson's disease (pd). pd is characterized by signs of major oxidative stress and mitochondrial damage in the pars compacta of the substantia nigra. present study was designed to investigate whether the centella asiatica extract (cae) would prevent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced neurotoxicity in aged sprague-dawley rats. adult, male sprague-dawley rat ... | 2010 | 20118623 |
| contact dermatitis due to centella asiatica. | 2010 | 20136880 | |
| two new triterpene glycosides from centella asiatica. | phytochemical investigation of the leaves of centella asiatica resulted in the isolation and characterization of eight triterpenes and/or saponins [which were characterized as 23- o-acetylmadecassoside (1), asiatic acid (2), madecassic acid (3), asiaticoside c (4), asiaticoside f (5), asiaticoside (6), madecassoside (7), and 23- o-acetylasiaticoside b (8)] together with sitosterol 3-o-beta-glucoside ( 9), stigmasterol 3- o- beta-glucoside (10), and querectin-3- o-beta-d-glucuronide (11). a new u ... | 2010 | 20143295 |
| evaluation of the anticonvulsant effect of centella asiatica (gotu kola) in pentylenetetrazol-induced seizures with respect to cholinergic neurotransmission. | the study described here was carried out to investigate the anticonvulsant effect of different extracts of centella asiatica with respect to cholinergic activity on pentylenetetrazol (ptz)-induced seizures. rats were randomly divided into eight groups of six rats each: nonepileptic rats treated with saline; ptz (60 mg/kg, ip)-induced seizure rats treated with saline; ptz-induced seizure rats pretreated with n-hexane, chloroform, ethyl acetate, n-butanol, and water extracts of c. asiatica; and pt ... | 2010 | 20144879 |
| apoptosis induction of centella asiatica on human breast cancer cells. | the present study evaluated the ability of methanolic extract of centella asiatica (linn) urban (umbelliferae) to induce apoptosis in different cancer cell lines. mcf-7 cells emerged as the most sensitive cell line for in vitro growth inhibitory activity. c. asiatica extract induced apoptosis in mcf-7 cells as indicated by nuclear condensation, increased annexin staining, loss of mitochondrial membrane potential and induction of dna breaks identified by tunel reactivity. it is possible that the ... | 2008 | 20162036 |
| protective effects of asiaticoside on acute liver injury induced by lipopolysaccharide/d-galactosamine in mice. | asiaticoside (as), a triterpenoid product isolated from centella asiatica, has been described to exhibit anti-in fl ammatory activities in several inflammatory models. however, the effects of as on liver injury are poorly understood. the present study was undertaken to investigate whether as is efficacious against lipopolysaccharide (lps) /d-galactosamine (d-galn)-induced acute liver injury in mice and its potential mechanisms. as (5, 10 and 20 mg/kg/d) was pretreated orally once daily for 3 day ... | 2010 | 20171071 |
| phytotherapeutics: an evaluation of the potential of 1000 plants. | the aim of this review is to evaluate and summarize the available scientific information on the commonest plant extracts marketed in western countries. in view of the intense, ongoing search for new plant extracts with powerful anti-inflammatory activity, we paid particular attention to this topic. the aim is to provide broad coverage of as many potentially useful plants as possible and then to focus on those with the greatest therapeutic potential. | 2010 | 20175810 |
| upregulation of phytosterol and triterpene biosynthesis in centella asiatica hairy roots overexpressed ginseng farnesyl diphosphate synthase. | farnesyl diphosphate synthase (fps) plays an essential role in organ development in plants. however, fps has not previously been identified as a key regulatory enzyme in triterpene biosynthesis. to elucidate the functions of fps in triterpene biosynthesis, c. asiatica was transformed with a construct harboring panax ginseng fps (pgfps)-encoding cdna coupled to the cauliflower mosaic virus 35s promoter. higher levels of cadds (c. asiatica dammarenediol synthase) and cacys (c. asiatica cycloarteno ... | 2010 | 20195611 |
| rapid screening of commercially available herbal products for the inhibition of major human hepatic cytochrome p450 enzymes using the n-in-one cocktail. | self-administration of complementary products concurrently with conventional medication is increasingly common. the potential for cytochrome p450 (cyp) inhibition requires investigation. the n-in-one assay with ten probe substrates for nine cyps was used with human liver microsomes to investigate ten products. cyp inhibition was measured in a single liquid chromatography-tandem mass spectrometry (lc/ms-ms) analysis. estimated ic(50)-values were determined for the extracts that produced significa ... | 2010 | 20218935 |
| madecassoside suppresses lps-induced tnf-alpha production in cardiomyocytes through inhibition of erk, p38, and nf-kappab activity. | madecassoside (ma) is a major triterpenoid component of centella asiatica that has a wide range of biological activities, including wound-healing and antioxidative activities. in the present study, we evaluated the therapeutic effect of ma on rat cardiac dysfunction during sepsis induced by lipopolysaccharide (lps), as well as the possible mechanism. pretreatment of the neonatal rat cardiomyocytes with ma inhibited lps-induced tnf-alpha production in a concentration-dependent manner. in addition ... | 2010 | 20381648 |
| in vitro modulatory effects on three major human cytochrome p450 enzymes by multiple active constituents and extracts of centella asiatica. | centella asiatica (ca) has been widely cultivated as a vegetable or spice in china, southeast asia, india, sri lanka, africa, and oceanic countries and traditionally used for wound healing and maintaining normal blood pressure. | 2010 | 20457244 |
| protective effects of asiaticoside on septic lung injury in mice. | asiaticoside (as), a major triterpenoid saponin component isolated from centella asiatica, has been described to exhibit antioxidant and anti-inflammatory activities. the present study aimed to determine the protective effects and the underlying mechanisms of as on septic lung injury induced by cecal ligation and puncture (clp). mice were pretreated with the as (45mg/kg) or as as well as gw9662 at 1h before clp, the survival, lung injury, inflammatory mediators and signaling molecules, and perox ... | 2010 | 20471230 |
| flavor characterization of sugar-added pennywort (centella asiatica l.) juices treated with ultra-high pressure and thermal processes. | the flavor characteristics of pennywort juices with added sugar treated by ultra-high pressure, pasteurization, and sterilization were investigated using solid phase microextraction combined with gas chromatography-mass spectrometry. it was found that sesquiterpene hydrocarbons comprised the major class of volatile components present and the juices had a characteristic aroma due to the presence of volatiles including beta-caryophyllene and humulene and alpha-copaene. in comparison with heated ju ... | 2010 | 20492095 |
| total phenolic compounds, flavonoids, and radical scavenging activity of 21 selected tropical plants. | free radical scavenging activity of 21 tropical plant extracts was evaluated using 1,1-diphenyl-2-picrylhydrazyl assay (dpph). total phenolic compounds and flavonoids were determined using folin-ciocalteu and hplc, respectively. results of the study revealed that all the plants tested exhibited excellent antioxidant activity with ic(50) in the range of 21.3 to 89.6 microg/ml. the most potent activity was demonstrated by cosmos caudatus (21.3 microg/ml) and piper betle (23.0 microg/ml) that are n ... | 2014 | 20492146 |
| antidiabetic screening of commercial botanical products in 3t3-l1 adipocytes and db/db mice. | numerous botanicals are purported to improve glucose metabolism and diabetic risk factors with varying degrees of supportive evidence. we investigated 203 commercially available botanical products representing 90 unique botanical species for effects on lipogenic activity in differentiating 3t3-l1 adipocytes. anti-inflammatory activity of 21 of these products was further assessed in tumor necrosis factor alpha (tnfalpha)-stimulated, mature 3t3-l1 adipocytes. from these results, rho-isoalpha acids ... | 2010 | 20521979 |
| evaluation of an onion extract, centella asiatica, and hyaluronic acid cream in the appearance of striae rubra. | this study evaluated the effect of an onion extract cream with centella asiatica and hyaluronic acid in improving the appearance of striae rubra (sr). women participants with bilateral, outer aspect of the thigh sr were randomized to apply a quarter-sized amount of the onion extract cream twice daily for 12 weeks to the randomized left or right, outer aspect of the thigh. no treatment was administered to the contralateral side. participants were evaluated at weeks 2, 4, 8, and 12. primary effica ... | 2010 | 20527138 |
| use of asiatic pennywort centella asiatica aqueous extract as a bath treatment to control columnaris in nile tilapia. | to develop antibiotic-free and chemical-free aquaculture, it is necessary to have natural substances to control diseases of aquatic animals. the aim of this study was to find an herb having therapeutic effect against columnaris, a fish disease caused by the bacterium flavobacterium columnare. of all tested herbs (including kalmegh andrographis paniculata, candle bush cassia alata, asiatic pennywort centella asiatica, mangosteen garcinia mangostana, pomegranate punica granatum, and guava psidium ... | 2010 | 20575361 |
| antispermatogenic and antifertility effect of pegaga (centella asiatica l) on the testis of male sprague-dawley rats. | antifertility agents with safety and effectiveness in terms of minimum side effects have always been a subject of debate. many studies have been conducted on plants to observe the antifertility effect, but majority of them were toxic. pegaga or centella asiatica l. is one of the popular herb traditionally consumed raw amongst people in malaysia. the main objective of the present study was to investigate the effects of centella asiatica l. extract on rat testis. | 2010 | 20589353 |
| anti-allergic, anti-pruritic, and anti-inflammatory activities of centella asiatica extracts. | this study investigated antipruritic and anti-inflammatory effect of centella asiatica extract in rats and anti-allergic in vitro using sheep (capra hircus) serum method and compound 48/80 induced mast cell degranulation method, compared with standard drug ketotifen fumarate. in rats, extract of centella asiatica administered orally was examined for anti-pruritic study and chlorpheniramine maleate was used as standard drug while carageenan paw induced inflammatory method was used for the antiinf ... | 2009 | 20606777 |
| evaluation of the wound healing potentials of two subspecies of hypericum perforatum on cultured nih3t3 fibroblasts. | for centuries, hypericum perforatum has been used in folk medicine to treat wounds. in the present study, the wound healing activities of extracts of h. perforatum ssp. perforatum (hpp) and h. perforatum ssp. veronense (hpv) were evaluated by comparing with a titrated extract of centella asiatica (teca) on nih3t3 fibroblasts. the cells were incubated with the extracts. using microscopical methods by staining cells, mitotic ability, morphological changes and collagen production in the fibroblasts ... | 2011 | 20632305 |
| carotenoid content and in vitro bioaccessibility of lutein in some leafy vegetables popular in sri lanka. | lutein is one of the major carotenoids in green leafy vegetables (glvs), which show a marked antioxidant activity. the study was carried out to identify and quantify the carotenoid content of selected sri lankan glvs. rp-hplc with photodiode array detection method was followed for the separation, identification and quantification of carotenoids. among the vegetables analyzed, ipomoea batatas leaves showed the highest beta-carotene content (743.9+/-35.0 microg/g dry weight (dw)) while syngonium a ... | 2010 | 20651462 |
| a clinical study on the management of generalized anxiety disorder with centella asiatica. | centella asiatica is reputed for its beneficial effects in various neurological disorders. the present investigation was undertaken to evaluate the role of 70% hydro-ethanolic extract of centella asiatica (ca) on generalized anxiety disorder (gad) in man. hamilton's brief psychiatric rating scale (bprs) was used to screen the subjects. thirty-three participants (18 male and 15 female; average age 33 yrs) were medicated with the ca in a fixed dose regime (500 mg/capsule, twice daily, after meal). ... | 2010 | 20677602 |
| in vitro biological evaluation of electrospun cellulose acetate fiber mats containing asiaticoside or curcumin. | ultra-fine cellulose acetate (ca; m(w) approximately 30,000 da; degree of acetyl substitution approximately 2.4) fiber mats containing either asiaticoside [from the plant centella asiatica (l.); either in the form of a crude extract (cace) or pure substance (pac)] or curcumin (cm; from the plant curcuma longa l.) were successfully prepared. the proposed use of these materials is as topical/transdermal patches or wound dressings. here, the potential for use of these herb-loaded ca fiber mats as w ... | 2010 | 20694988 |
| an ethnopharmacological study on verbascum species: from conventional wound healing use to scientific verification. | the leaves, flowers, and whole aerial parts of verbascum l. (scrophulariaceae) species are used to treat eczema and other types of inflammatory skin conditions and as a desiccant for wounds in turkish traditional medicine. in the present study, the methanolic extracts of 13 verbascum species growing in turkey, including verbascum chionophyllum hub.-mor., verbascum cilicicum boiss., verbascum dudleyanum (hub.-mor.) hub.-mor., verbascum lasianthum boiss., verbascum latisepalum hub.-mor., verbascum ... | 2010 | 20709167 |
| the antiepileptic effect of centella asiatica on the activities of na/k, mg and ca-atpases in rat brain during pentylenetetrazol-induced epilepsy. | to study the anticonvulsant effect of different extracts of centella asiatica (ca) in male albino rats with reference to na(+)/k(+), mg(2+) and ca(2+)-atpase activities. | 2010 | 20711371 |
| neuroprotective effects of centella asiatica against intracerebroventricular colchicine-induced cognitive impairment and oxidative stress. | oxidative stress appears to be an early event involved in the pathogenesis of alzheimer's disease. the present study was designed to investigate the neuroprotective effects of centella asiatica against colchicine-induced memory impairment and oxidative damage in rats. colchicine (15 mug/5 mul) was administered intracerebroventricularly in the lateral ventricle of male wistar rats. morris water maze and plus-maze performance tests were used to assess memory performance tasks. various biochemical ... | 2009 | 20798885 |
| characterisation and immuno-stimulating activity of polysaccharides from thai medicinal plants. | water-soluble polysaccharides were isolated from the tubers of butea superba roxb. and pueraria candollei wall. ex benth. var. mirifica (shaw et suvat.) c. niyomdham, the leaves of centella asiatica (l.) urb, ocimum basilicum l., psidium guajava and andrographis paniculata (burn. f.) nees, the stems of cymbopogon citratus (stapf exg), and the fruits of psidium guajava and scaphium scaphigerum. the immunological impacts of the polysaccharides on t-lymphocyte proliferation in vitro was investigate ... | 2010 | 20812129 |
| microbial transformation of asiatic acid by alternaria longipes. | asiatic acid is a major pentacyclic triterpene isolated from centella asiatica. it shows a variety of bioactivities. in order to obtain its derivatives, potentially useful for detailed pharmacological studies, the substrate was subjected to incubations with selected micro-organisms. in this work, asiatic acid was converted into three new compounds: 2α,3β,23,30-tetrahydroxyurs-12-ene-28-oic acid (1), 2α,3β,22β,23-tetrahydroxyurs-12-ene-28-oic acid (2), and 2α,3β,22β,23,30-pentahydroxyurs-12-ene-2 ... | 2010 | 20839122 |
| [effects of compound centella asiatica enema on kidneys coefficient, electrolytes and blood in chronic renal failure rats]. | to study the pharmacological effects of compound centella asiatica enema on chronic renal failure (crf) rats. | 2010 | 20873565 |
| the role of natural products in the discovery of new drug candidates for the treatment of neurodegenerative disorders ii: alzheimer's disease. | the present review is part ii in a series (part i focuses on parkinson's disease) that addresses the value of natural product chemistry in the discovery of medicines for the treatment of neurodegenerative disorders. data reviewed document that a host of products from plant species and derivatives have neuroprotectant effects in vitro and in vivo. in addition, besides neuroprotection, natural products also demonstrate biological effects that target biochemical pathways underlying associated sympt ... | 2011 | 20874701 |
| in vitro modulatory effects of andrographis paniculata, centella asiatica and orthosiphon stamineus on cytochrome p450 2c19 (cyp2c19). | ethno pharmacological relevance: andrographis paniculata (ap), centella asiatica (ca) and orthosiphon stamineus (os) are three popular herbs traditionally used worldwide. ap is known for the treatment of infections and diabetes and ca is good for wound healing and healthy skin while os is usually consumed as tea to treat kidney and urinary disorders. interaction of these herbs with human cytochrome p450 2c19 (cyp2c19), a major hepatic cyp isoform involved in metabolism of many clinical drugs has ... | 2010 | 21093571 |
| effects of asiatic acid on passive and active avoidance task in male spraque-dawley rats. | centella asiatica has a reputation to restore declining cognitive function in traditional medicine. to date, only a few compounds that show enhancing learning and memory properties are available. therefore, the present study investigates the effects of for acute administration of asiatic acid (a-a) isolated from centella asiatica administration on memory and learning in male spraque-dawley rats. | 2010 | 21167268 |
| preparation of a specific monoclonal antibody to asiaticoside for the development of an enzyme-linked immunosorbent assay. | asiaticoside (as), the major active component of centella asiatica (l.) urban, is used as a memory enhancer and for wound healing. we have successfully prepared monoclonal antibodies (mabs) against as, and developed an enzyme-linked immunosorbent assay (elisa) system for its determination. as was conjugated to the carrier protein bovine serum albumin (bsa), which acted as an immunogen. in order to confirm its immunogenicity, the ratio of hapten in the as-bsa conjugate was determined by matrix-as ... | 2010 | 21180694 |
| characterization of an ursane triterpenoid from centella asiatica with growth inhibitory activity against spilarctia obliqua. | a new triterpenoid glycoside 3-o-[a-l-arabinopyranosyl] 2 a, 3 ß , 6 ß , 23-a tetrahydroxyurs-12-ene-28-oic acid ( 1 ) accompanied by 6ß-hydroxyasiatic acid and asiatic acid were isolated from centella asiatica . the structure of 1 was established by physicochemical data. compound 1 exhibited dose-dependent growth inhibitory activity against larvae of spilarctia obliqua but was not as active as azadirachtin. | 2000 | 21214472 |
| asiaticoside suppresses collagen expression and tgf-β/smad signaling through inducing smad7 and inhibiting tgf-βri and tgf-βrii in keloid fibroblasts. | asiaticoside (ats) isolated from the leaves of centella asiatica possesses strong wound-healing properties and reduces scar formation. however, the specific effects of asiaticoside on the formation of keloidal scars remain unknown. in the present study, we evaluated the in vitro effects of asiaticoside on the proliferation, collagen expression, and transforming growth factor (tgf)-β/smad signaling of keloid-derived fibroblasts. fibroblasts isolated from keloid tissue and normal skin tissues were ... | 2011 | 21240513 |
| triterpene composition and bioactivities of centella asiatica. | leaves of centella asiatica (centella) were analysed for their triterpene composition and bioactivity such as collagen enhancement, antioxidant, anticellulite and uv protection capacity properties. triterpenes of centella were measured using hplc-pad on an excil ods 5 mm (c18) column for the simultaneous determination of asiatic acid, madecassic acid, asiaticoside and madecassoside. centella was found to contain significant amounts of madecassoside (3.10 ± 4.58 mg/ml) and asiaticoside (1.97 ± 2. ... | 2011 | 21278681 |
| the efficacy and side effects of oral centella asiatica extract for wound healing promotion in diabetic wound patients. | to study clinical efficacy and side effects of the oral centella asiatica extract capsule in the diabetic wound healing. and to study the side effects of centella asiatica extract capsule. | 2010 | 21298840 |
| combination of flavonoids with centella asiatica and melilotus for diabetic cystoid macular edema without macular thickening. | the purpose of this study was to evaluate the orally administered combination of flavonoids desmin and troxerutin with centella asiatica and melilotus for the treatment of diabetic cystoid macular edema (cme) without macular thickening. | 2011 | 21314440 |
| gotu kola induced hepatotoxicity in a child - need for caution with alternative remedies. | 2011 | 21334992 | |
| a new ursane-type triterpenoid glycoside from centella asiatica leaves modulates the production of nitric oxide and secretion of tnf-α in activated raw 264.7 cells. | one new ursane-type triterpenoid glycoside, asiaticoside g (1), five triterpenoids, asiaticoside (2), asiaticoside f (3), asiatic acid (4), quadranoside iv (5), and 2α,3β,6β-trihydroxyolean-12-en-28-oic acid 28-o-[α-l-rhamnopyranosyl-(1→4)-β-d-glucopyranosyl-(1→6)-β-d-glucopyranosyl] ester (6), and four flavonoids, kaempferol (7), quercetin (8), astragalin (9), and isoquercetin (10) were isolated from the leaves of centella asiatica. their chemical structures were elucidated by mass, 1d- and 2d- ... | 2011 | 21353543 |
| wound healing acceleration effect of endemic ononis species growing in turkey. | ononis l. species have been used for healing of wounds, eczema and rheumatic complaints, against skin cancer and lesions and topically used as antiseptic and antimicrobial agent in folk medicine. in the present study, the aqueous and methanolic extracts of three endemic ononis species growing in turkey, including ononis sessilifolia bornm., ononis basiadnata hub.-mor. and ononis macrosperma hub.-mor. were assessed for their in vivo wound healing and anti-inflammatory activities. | 2011 | 21354296 |
| carotenoid and mineral content of different morphotypes of centella asiatica l. (gotukola). | six morphotypes of centella asiatica designated g(1), g(2), g(3), g(7), g(8) and g(12) were analyzed for carotenoid content, proximate components and selected dietary minerals. potassium was found to be the major element present in c. asiatica and the content in g(1) and g(3) (6,165.0 ± 125.8 mg/100 g dry weight) was significantly (p < 0.05) higher than all other morphotypes. c. asiatica is more popular for its higher contents of iron and calcium. however, no significant (p>0.05) differences in ... | 2011 | 21391792 |
| development and validation of high-performance liquid chromatography/electrospray ionization mass spectrometry for assay of madecassoside in rat plasma and its application to pharmacokinetic study. | a rapid, sensitive and specific high-performance liquid chromatography/electrospray ionization mass spectrometric (lc-esi-ms) method was developed and validated for the quantification of madecassoside, a major active constituent of centella asiatica (l.) urb. herbs, in rat plasma. with paeoniflorin as an internal standard (is), a simple liquid-liquid extraction process was employed for the plasma sample preparation. chromatographic separation was achieved within 6?min on a shim-pack clc-ods colu ... | 2011 | 21413047 |
| antinociceptive activities and the mechanisms of anti-inflammation of asiatic acid in mice. | asiatic acid (aa), a pentacyclic triterpene compound in the medicinal plant centella asiatica, was evaluated for antinociceptive and anti-inflammatory effects. treatment of male icr mice with aa significantly inhibited the numbers of acetic acid-induced writhing responses and the formalin-induced pain in the late phase. in the anti-inflammatory test, aa decreased the paw edema at the 4th and 5th h after λ-carrageenan (carr) administration and increased the activities of catalase (cat), superoxid ... | 2011 | 21584194 |
| estimation of proximate composition, micronutrients and phytochemical compounds in traditional vegetables from andaman and nicobar islands. | in present study, 10 preferred traditional vegetables from andaman and nicobar islands, india, were analysed for nutritional profiles. moisture content in their edible parts ranged from 83.43 to 94.78%. maximum ash content was recorded in portulaca oleracea, crude protein in colocasia esculenta, crude fibre in eryngium foetidum and fat in e. foetidum. phosphorus was maximum in ipomea aquatica, potassium in c. esculenta, zinc, calcium and manganese in centella asiatica, copper in sauropus androgy ... | 2011 | 21615278 |
| centella asiatica attenuates d-galactose-induced cognitive impairment, oxidative and mitochondrial dysfunction in mice. | d-galactose induced neurotoxicity is well known model for studying aging and related oxidative damage and memory impairment. aging is a biological process, characterized by the gradual loss of physiological functions by unknown mechanism. centella asiatica, indian pennywort has been documented in the treatment of various neurological disorders including aging. therefore, present study has been conducted in order to explore the possible role of centella asiatica against d-galactose induced cognit ... | 2011 | 21629743 |
| irbic acid, a dicaffeoylquinic acid derivative from centella asiatica cell cultures. | 3,5-o-dicaffeoyl-4-o-malonilquinic acid (1) (irbic acid) has been isolated for the first time from cell cultures of centella asiatica and till now it has never been reported to be present in the intact plant. evidence of its structure was obtained by spectroscopic analyses (ms/nmr). besides 1, cell cultures produce also the known 3,5-o-dicaffeoylquinic acid, chlorogenic acid, and the triferulic acid 2 (4-o-8'/4'-o-8″-didehydrotriferulic acid). biological activities were evaluated for compound 1, ... | 2011 | 21635941 |
| induction of root colonization by piriformospora indica leads to enhanced asiaticoside production in centella asiatica. | centella asiatica (indian pennywort) has wide application in indian and chinese traditional medicines with documented evidence for wound healing and neuroprotective and anti-aging potential. asiaticoside, a trisaccharide triterpene, is the most medicinally active compound in the plant. β-amyrin synthase and squalene synthase have been identified as the two key genes in the triterpenoid pathway which regulate the production of asiaticoside in c. asiatica. the paper reports salient findings of our ... | 2012 | 21688071 |
| effects of acute gamma irradiation on physiological traits and flavonoid accumulation of centella asiatica. | in the present study, two accessions of centella asiatica (ca03 and ca23) were subjected to gamma radiation to examine the response of these accessions in terms of survival rate, flavonoid contents, leaf gas exchange and leaf mass. radiation sensitivity tests revealed that based on the survival rate, the ld(50) (gamma doses that killed 50% of the plantlets) of the plantlets were achieved at 60 gy for ca03 and 40 gy for ca23. the nodal segments were irradiated with gamma rays at does of 30 and 40 ... | 2011 | 21694666 |
| pharmacological review on centella asiatica: a potential herbal cure-all. | in recent times, focus on plant research has increased all over the world. centella asiatica is an important medicinal herb that is widely used in the orient and is becoming popular in the west. triterpenoid, saponins, the primary constituents of centella asiatica are manly believed to be responsible for its wide therapeutic actions. apart from wound healing, the herb is recommended for the treatment of various skin conditions such as leprosy, lupus, varicose ulcers, eczema, psoriasis, diarrhoea ... | 2010 | 21694984 |
| arsenic accumulation in native plants of west bengal, india: prospects for phytoremediation but concerns with the use of medicinal plants. | arsenic (as) is a widespread environmental and food chain contaminant and class i, non-threshold carcinogen. plants accumulate as due to ionic mimicry that is of importance as a measure of phytoremediation but of concern due to the use of plants in alternative medicine. the present study investigated as accumulation in native plants including some medicinal plants, from three districts [chinsurah (hoogly), porbosthali (bardhman), and birnagar (nadia)] of west bengal, india, having a history of a ... | 2012 | 21713498 |
| electrospun gelatin fiber mats containing a herbal-centella asiatica-extract and release characteristic of asiaticoside. | ultra-fine gelatin (type a, porcine skin, ∼180 bloom) fiber mats containing a methanolic crude extract of centella asiatica (l.) urban, a medicinal plant widely known for its traditional medical applications including its wound healing ability, were fabricated, for the first time, from the neat gelatin solution (22% w/v in 70 vol% acetic acid) containing the crude extract (mca) in various amounts (i.e. 5-30 wt% based on the weight of gelatin powder) by electrospinning. incorporation of mca in th ... | 2008 | 21730522 |
| two new dammarane monodesmosides from centella asiatica. | two new dammarane monodesmosides centellosides a (1) and b (2), and two new natural products ginsenosides mc (10) and y (11), together with 11 known compounds (3-9 and 12-15) reported for the first time from this genus, were isolated from the whole plants of centella asiatica. all structures were elucidated by spectroscopic techniques and chemical methods, and compared with literature values. all the isolated compounds were evaluated in vitro for cytotoxicity. | 2011 | 21751844 |
| a new cyclodextrin-grafted viscose loaded with aescin formulations for a cosmeto-textile approach to chronic venous insufficiency. | cosmeto-textile applications can be used in the treatment of chronic venous insufficiency in legs by means of elastic bandages loaded with natural products which possess flebotonic properties. we have developed an efficient synthetic procedure for the preparation of β-cyclodextrin (β-cd)-grafted viscose by means of a 2-step ultrasound-assisted reaction. the highly grafted fabric bearing bis-urethane bridged β-cd has been characterized by atr-ftir and cp-mas spectra and by an empiric colorimetric ... | 2011 | 21805331 |
| wound repair and anti-inflammatory potential of essential oils from cones of pinaceae: preclinical experimental research in animal models. | ethnobotanical surveys revealed that abies bornmulleriana, abies cilicica, abies nordmanniana and cedrus libani have been used to promote wound healing in turkish folk medicine. four different fir species (abies cilicica subsp. cilicica, abies nordmanniana subsp. bornmulleriana, abies nordmanniana subsp. equi-trojani, and abies nordmanniana subsp. nordmanniana), cedrus libani and picea orientalis were assessed for their in vivo wound healing and anti-inflammatory activities. | 2011 | 21816214 |
| [studies on fingerprints of centella asiatica by hplc]. | to study the hplc fingerprints and establish a sensitive and specific method for controlling the quality of centella asiatica. | 2011 | 21818967 |
| trends in aging and skin care: ayurvedic concepts. | the association between ayurveda, anti-aging and cosmeceuticals is gaining importance in the beauty, health and wellness sector. ayurvedic cosmeceuticals date back to the indus valley civilization. modern research trends mainly revolve around principles of anti-aging activity described in ayurveda: vayasthapana (age defying), varnya (brighten skin-glow), sandhaniya (cell regeneration), vranaropana (healing), tvachya (nurturing), shothahara (anti-inflammatory), tvachagnivardhani (strengthening sk ... | 2010 | 21836797 |
| protective role of centella asiatica on lead-induced oxidative stress and suppressed reproductive health in male rats. | centella asiatica has been mentioned in ancient ayurvedic text of the indian system of medicine for its properties to promote intelligence. the objective of the present study was to investigate the beneficial effects of c. asiatica on lead-induced oxidative stress and suppressed reproductive performance in male rats. significant decrease in the weights of testes and epididymis were observed in lead treated animals. exposure to lead acetate significantly increased malondialdehyde levels with a si ... | 2011 | 21843793 |
| genetic diversity of centella asiatica in china analyzed by inter-simple sequence repeat (issr) markers: combination analysis with chemical diversity. | centella asiatica is an important plant species used in traditional chinese medicine. to help the efficient use and conservation of this species, the genetic diversity of c. asiatica populations in china was investigated using inter-simple sequence repeat (issr) markers. fourteen natural populations comprising 162 individuals were included to estimate genetic diversity. at the species level, genetic diversity was relatively high (p = 66.33%, h = 0.2183, i = 0.3305). at the population level, the ... | 2012 | 21853385 |
| treatment with centalla asiatica (linn) fresh leaf extract enhances learning ability and memory retention power in rats. | to investigate the role of centella asiatica (cea) fresh leaf extract treatment on the behavior, especially learning and memory, of adult rats. | 2007 | 21857576 |
| The inductive effects of Centella asiatica on rat spermatogenic cell apoptosis in vivo. | Centella asiatica (L.) Urban has been traditionally used for the treatment of various disease and as a food for thousands of years in various parts of the world including eastern Asia, China and India. The goal of this study was to investigate the effects of Centella asiatica aqueous leaf extract on the induction of spermatogenic cell apoptosis in male rats. After lethal dose (LD(50)) assessment of plant extract, rats were divided in five groups. The experimental groups received orally 10, 50, 8 ... | 2011 | 21870191 |
| a rapid one-step immunochromatographic assay for the detection of asiaticoside. | asiaticoside has been identified as the most active compound in centella asiatica. in order to screen a large number of plant samples for the presence of asiaticoside, a rapid and simple technique is required that utilizes small quantities for test samples. in this study, an immunochromatographic strip test has been developed for the detection of asiaticoside in plant samples that uses a monoclonal antibody against asiaticoside. the limit of detection for the strip test was 12.5 μg/ml. immunoass ... | 2012 | 21874622 |
| common complementary and alternative therapies with potential use in dermatologic surgery: risks and benefits. | ambulatory surgery patients often use complementary and alternative medicine (cam) therapies. cam therapies may create beneficial and detrimental perioperative conditions. | 2013 | 21890235 |
| Enhancement of the Skin-Protective Activities of Centella asiatica L. Urban by a Nano-encapsulation Process. | Aqueous extracts of Centella asiatica L. Urban were encapsulated by an edible biopolymer, gelatin, which has no effect on their cosmetic activities. The nanoparticles were w/o-type spherical liposomes that had an average diameter of 115.0nm. The encapsulation efficiency was estimated to be approximately 67%, which was relatively high for these aqueous extracts. The nanoparticles showed lower cytotoxicity (10%) in human skin fibroblast cells than the unencapsulated crude extract (15%) at 1.0mg/ml ... | 2012 | 21893113 |
| growth and asiaticoside production in multiple shoot cultures of a medicinal herb, centella asiatica (l.) urban, under the influence of nutrient manipulations. | growth and in vitro asiaticoside accumulation in multiple shoot cultures of centella asiatica (l.) urban was studied as a function of nutrient manipulations in the culture media. shoot cultures raised in liquid murashige and skoog medium supplemented with 2.5 mg/l kinetin attained a growth index (gi) of 6.06 along with the highest asiaticoside content of 3.8 mg/g dry weight on the 35th day of the culture cycle. the shoot growth and asiaticoside accumulation were found to be influenced by the rel ... | 2012 | 21947691 |
| antioxidant capacity and phenolic composition of fermented centella asiatica herbal teas. | c. asiatica was exposed to various fermentations: no fermentation (0 min), partial fermentation (120 min) and full fermentation (24 h). total phenolic content (tpc) and ferric-reducing antioxidant power (frap) of c. asiatica infusions were studied as a function of water temperature (60, 80 or 100 °c), the brewing stage (one, two or three) and the brewing time (1, 3, 5, 10, 15 or 20 min). the optimum brewing procedure was adopted to study the antioxidant properties and phenolic compounds in c. as ... | 2011 | 21987075 |
| regeneration of centella asiatica plants from non-embryogenic cell lines and evaluation of antibacterial and antifungal properties of regenerated calli and plants. | abstract: | 2011 | 21989222 |
| asiaticoside: attenuation of neurotoxicity induced by mptp in a rat model of parkinsonism via maintaining redox balance and up-regulating the ratio of bcl-2/bax. | in this study, we investigated the neuroprotective effects of asiaticoside, a triterpenoid saponin isolated from the chinese medicinal herb centella asiatica, in the rats model of parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). rats were first injected with mptp. one day after surgery, asiaticoside was administered and the behavioral tests were assessed. on 14th day, the rats were sacrificed, substantia nigra (sn) and striatum were dissected, and then dopamine (da) a ... | 2012 | 22001429 |
| flavonoid and leaf gas exchange responses of centella asiatica to acute gamma irradiation and carbon dioxide enrichment under controlled environment conditions. | the study was couducted to investigate the effects of gamma irradiation and co₂ on flavonoid content and leaf gas exchange in c.asiatica. for flavonoid determination, the design was a split split plot based on randomized complete block design (rcbd). for other parameters, the designs were split plots. statistical tests revealed significant differences in flavonoid contents of centella asiatica leaves between different growth stages and various co₂ treatments. co₂ 400, g20 (400 = ambient co₂; g20 ... | 2011 | 22027950 |
| Exploring the role of "Brahmi" (Bocopa monnieri and Centella asiatica) in brain function and therapy. | It has been envisaged that in this century, disorders of the central nervous system will have a significant bearing on the healthcare concerns of the human population worldwide. Such neurological and psychiatric disorders are generally associated with loss of memory, cognitive deficits, impaired mental function etc. Due to the multi-factorial nature of these diseases, modern medicine based psychoactive drugs have met with limited success. Therefore, there is a growing demand for novel products t ... | 2011 | 22074576 |
| discrimination of three pegaga (centella) varieties and determination of growth-lighting effects on metabolites content based on the chemometry of 1h nuclear magnetic resonance spectroscopy. | the metabolites of three species of apiaceae, also known as pegaga, were analyzed utilizing (1)h nmr spectroscopy and multivariate data analysis. principal component analysis (pca) and hierarchical cluster analysis (hca) resolved the species, centella asiatica, hydrocotyle bonariensis, and hydrocotyle sibthorpioides, into three clusters. the saponins, asiaticoside and madecassoside, along with chlorogenic acids were the metabolites that contributed most to the separation. furthermore, the effect ... | 2012 | 22084897 |
| centella asiatica extracts modulate hydrogen peroxide-induced senescence in human dermal fibroblasts. | centella asiatica (c. asiatica) is a pharmacological plant in south asia. it has been demonstrated that c. asiatica extracts containing various pentacyclic triterpenes exert healing effects, especially wound healing and collagen synthesis in skin. however, there are few studies on the effect of c. asiatica extracts on stress-induced premature senescence (sips). to determine whether h(2) o(2) -induced senescence is affected by c. asiatica extracts, we performed senescence analysis on cultured hum ... | 2011 | 22092576 |
| teca (titrated extract of centella asiatica): new microcirculatory, biomolecular, and vascular application in preventive and clinical medicine. a status paper. | plant-derived elements used for pharmacological applications constitute an increasing research field. centella asiatica is widely used mainly as an extract (teca). triterpenic fractions, the primary constituents of centella asiatica, produce a wide range of preventive and therapeutic effects. the modulation of collagen production and deposition in wound healing is of primary importance. teca is also used to treat several microcirculatory problems, inflammatory skin conditions (leprosy, lupus, va ... | 2011 | 22108486 |
| inhibitory effect of asiatic acid on acetylcholinesterase, excitatory post synaptic potential and locomotor activity. | the asiatic acid, a triterpenoids isolated from centella asiatica was used to delineate its inhibitory effect on acetylcholinesterase (ache) properties, excitatory post synaptic potential (epsp) and locomotor activity. this study is consistent with asiatic acid having an effect on ache, a selective gaba(b) receptor agonist and no sedative effect on locomotor. | 2012 | 22112723 |
| clinical evaluation of shilajatu rasayana in patients with hiv infection. | aids is one of the serious global health concerns caused by human immuno deficiency(hiv) virus and is predominantly a sexually transmitted disease. currently there is no vaccine or cure for aids still anti retroviral therapy (art) is successful. it reduces both the mortality and the morbidity of hiv infection, but is expensive and inaccessible in many countries. however intense the therapy may be, hiv virus is rarely eliminated, and drug resistance is a major setback during long-term therapy. th ... | 2010 | 22131681 |
| in vitro inhibitory potential of selected malaysian plants against key enzymes involved in hyperglycemia and hypertension. | this study was conducted to determine the inhibitory potential of selected malaysian plants against key enzymes related to type 2 diabetes and hypertension. | 2011 | 22135867 |
| sri lankan rice mixed meals: effect on glycaemic index and contribution to daily dietary fibre requirement. | the glycaemic index (gi) concept ranks starchy foods according to the blood glucose responses following ingestion. when considering commonly consumed sri lankan meals, only a few can be categorised as low gi. however, a significant negative correlation between the gi of sri lankan meals and fibre content has been observed indicating the potential to reduce the gi of meals by incorporating naturally occurring sources of fibre. thus, the objective of this study was to study the effect of increased ... | 2011 | 22135869 |
| asiatic acid protects primary neurons against c2-ceramide-induced apoptosis. | ceramides derived from sphingosine contribute to the apoptotic processes of neuronal cells in neurodegenerative disorders including alzheimer's disease. this study investigates the potential neuroprotective effects of asiatic acid, a triterpenoid derived from centella asiatica, against c(2)-ceramides-induced cell death in primary cultured rat cortical neuronal cells. in primary neurons, asiatic acid (0.01 to 1.0 μmol/l) reduced c(2)-ceramide-induced cell death and mitochondria membrane potential ... | 2012 | 22296759 |
| aqueous extract of centella asiatica promotes corneal epithelium wound healing in vitro. | centella asiatica is a traditional herbal medicine that has been shown to have pharmacological effect on skin wound healing, and could be potential therapeutic agent for corneal epithelial wound healing. | 2012 | 22301444 |
| ethnobotanical treatment strategies against alzheimer's disease. | ethnobotany encompasses the cultural uses of plants by humans, including their uses as medicines (ethnopharmacology). the reputed medicinal properties of plants have been documented for centuries in different cultures, and there are many plant species that have been traditionally used for memory disorders, which are now being explored to determine any scientific basis for their reputed uses. plants have been a valuable source of drugs, and phytochemicals have also provided templates to develop s ... | 2012 | 22329652 |
| the influence of certain taxonomic and environmental parameters on biomass production and triterpenoid content in the leaves of centella asiatica (l.) urb. from madagascar. | centella asiatica (apiaceae family; talapetraka in malagasy) is a tropical and subtropical plant with leaves containing glycotriterpenoids (asiaticosides) used in traditional and modern medicine. c. asiatica is collected exclusively in natural stands. it is madagascar's second most important indigenous plant export. the objective in this study is to provide data which will make it possible to optimize the harvest and thus effectively develop this resource. two foliar morphotypes were identified: ... | 2012 | 22344906 |
| evaluation of antioxidant activity of two important memory enhancing medicinal plants baccopa monnieri and centella asiatica. | free radicals or highly reactive oxygen species are capable of inducing oxidative damage to human body. antioxidants are the compounds which terminate the attack of reactive species and reduce the risk of diseases. both baccopa monnieri and centella asiatica are used in treatment of brain disorders in humans and have almost similar effects. | 2012 | 22345883 |
| madecassoside suppresses migration of fibroblasts from keloids: involvement of p38 kinase and pi3k signaling pathways. | keloid is a specific skin scar that expands beyond the boundaries of the original injury as it heals. the invasive nature of keloid and notable migratory activity of fibroblasts are a hallmark, which distinguishes keloids from other common scars. madecassoside, a triterpenoid saponin occurring in centella asiatica herbs, possesses unique pharmacological properties to enhance wound-healing and diminish keloid formation. however, the effects of madecassoside on the formation of keloid scars have b ... | 2012 | 22360962 |
| evaluation of comparative free-radical quenching potential of brahmi (bacopa monnieri) and mandookparni (centella asiatica). | ayurvedic texts describe rejuvenate measures called rasayana to impart biological sustenance to bodily tissues. rasayana acting specifically on brain are called medhya rasayana. brahmi is one of the most commonly practiced herbs for the same. yet there exist a controversy regarding the exact plant species among bacopa monnieri l. penn (bm) and centella asiatica (l.) urban (ca) to be used as brahmi in the formulations. though the current literature available has suggested a very good nootropic po ... | 2011 | 22408313 |
| optimization of an efficient semi-solid culture protocol for sterilization and plant regeneration of centella asiatica (l.) as a medicinal herb. | the present study investigates the effects of different concentrations, as well as type of plant growth regulators (pgrs) and medium (ms, duchefa) on the growth and development of centella asiatica in semi-solid culture. in addition, a protocol for successful sterilization of c.asiatica explants prepared from field-grown plants highly exposed to fungal and bacterial contamination was determined. results for sterilization treatments revealed that applying hgcl₂ and plant preservative mixture (ppm ... | 2011 | 22439138 |