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molecular characterization of echovirus 30-associated outbreak of aseptic meningitis in guangdong in 2012.evaluation of the primary etiologic agents that cause aseptic meningitis outbreaks may provide valuable information regarding the prevention and management of aseptic meningitis. an outbreak of aseptic meningitis occurred from may to june, 2012, in guangdong province, china. in order to determine the etiologic agent, csf specimens from 121 children hospitalized for aseptic meningitis at luoding people's hospital of guangdong province were tested for virus isolation and identification.201323968330
complete genome sequence analysis of human echovirus 30 isolated during a large outbreak in guangdong province of china, in 2012.in may and june 2012, an outbreak of aseptic meningitis caused by echovirus 30 (e30) occurred on a large scale in luoding, guangdong province, china. our team successfully isolated one subtype, strain 2012em161, and its complete genome was sequenced. the phylogenetic tree of viral protein (vp) 1 gene sequences showed that the viral isolate was similar to the e30 strain prevalent in fujian (2011), with identity of 98.05-99.32 % and 98.63-99.32 % for nucleotides and amino acids respectively. whole ...201423990054
an approach for differentiating echovirus 30 and japanese encephalitis virus infections in acute meningitis/encephalitis: a retrospective study of 103 cases in vietnam.in recent decades, echovirus 30 (e30) and japanese encephalitis virus (jev) have been reported to be the common causative agents of acute meningitis among patients in south east asia. an e30 outbreak in vietnam in 2001-2002 gained our interest because the initial clinical diagnosis of infected patients was due to jev infection. there are few clinical insights regarding e30 cases, and there are no reports comparing e30 and jev acute meningitis/encephalitis cases based on clinical symptoms and cas ...201324025733
recent outbreak of aseptic meningitis in italy due to echovirus 30 and phylogenetic relationship with other european circulating strains.enteroviruses (evs) are common human viral pathogens, causing a variety of diseases, including aseptic meningitis. recently, ev aseptic meningitis outbreaks have been reported across europe, but, in italy, knowledge of recent ev molecular epidemiology is very limited.201324051044
increased levels of cytokines in cerebrospinal fluid of children with aseptic meningitis caused by mumps virus and echovirus 30.we measured levels of pro-inflammatory cytokines in the cerebrospinal fluid (csf) of patients with mumps meningitis, enteroviral echovirus 30 meningitis and children without central nervous system infection to investigate whether these molecules were involved in the pathogenesis of viral meningitis. the csf was obtained from 62 children suspected with meningitis. these patients were classified to the mumps meningitis (n = 19), echovirus 30 meningitis (n = 22) and non-meningitis (n = 21) groups. ...201424313836
novel and predominant pathogen responsible for the enterovirus-associated encephalitis in eastern china.enteroviruses (ev) have been increasingly identified as the causative agent for unknown etiological encephalitis in many parts of the world, but the long period surveillance for enterovirus-associated encephalitis (eae) was not reported in china. from 2002-2012 in zhejiang, coxsackieviruses a9, b1, b2, b3, b4, b5; and echoviruses 3, 4, 6, 9, 14, 25, 30 were detected from the unknown etiological encephalitis cases, with coxsackievirus b4 been identified here for the first time. from 2002-2004 and ...201324386442
detection and genotyping of enteroviruses in cerebrospinal fluid in patients in victoria, australia, 2007-2013.genotyping by vp1 fragment polymerase chain reaction (pcr) and nucleic acid sequencing to detect enterovirus (ev) genotypes was performed directly on 729 ev pcr positive cerebrospinal fluid (csf) samples collected between 2007 and 2012 from victorian hospital inpatients. the overall genotype identification rate from csf-positive material was 43%. the four most common genotypes identified were echovirus 6 (24%), echovirus 30 (17%), echovirus 25 (10%), and coxsackievirus a9 (10%), together compris ...201424474149
aseptic meningitis outbreak caused by echovirus 30 in two regions in bulgaria, may-august 2012.an aseptic meningitis outbreak emerged in two regions in bulgaria in 2012 and echovirus 30 (e30) was established as the aetiological agent by cell culture isolation, serological test, and molecular-based techniques. a total of 157 patients with aseptic meningitis were investigated, of which 117 were confirmed as having e30-associated disease. molecular analysis of 12 e30 isolates revealed 99-100% nucleotide and amino-acid identity between them and a close correlation with a greek strain involved ...201424480099
widespread circulation of a new echovirus 30 variant causing aseptic meningitis and non-specific viral illness, south-east france, 2013.human enteroviruses (hevs) are major cause of aseptic meningitis. a new outbreak of e-30 occurred between april and september 2013 in marseille, south-east france.201424973284
emergence of enterovirus 71 c4a in denmark, 2009 to 2013.enterovirus (ev) 71 has emerged as a primary cause of severe neurologic enterovirus infection in the aftermath of the global polio eradication effort. eleven subgenotypes of ev71 exist, the c4 subgenotype being associated with large outbreaks in asia with high mortality rates. this subgenotype has rarely been reported in europe. in the period between 1 january 2009 and 31 december 2013 a total of 1,447 ev positive samples from 1,143 individuals were sent to the statens serum institute (ssi), and ...201425306878
ev71 vaccines: a first step towards multivalent hand, foot and mouth disease vaccines.enterovirus a infections are the primary cause of hand, foot and mouth disease in infants and young children. enterovirus 71 (ev71) and coxsackievirus a16 have emerged as neurotropic viruses responsible for severe neurological complications and a serious public health threat across the asia-pacific region. formalin-inactivated ev71 vaccines have elicited protection against ev71 but not against coxsackievirus a16 infections. the development of a bivalent formalin-inactivated ev71/fi coxsackieviru ...201525536888
aseptic meningitis outbreak associated with echovirus 30 among high school football players--los angeles county, california, 2014.on august 4, 2014, the acute communicable disease control program of the los angeles county department of public health received a report of three aseptic meningitis cases among football players at a county high school. an investigation was conducted to determine the extent of the outbreak, identify potential exposures, and recommend control measures. an outbreak-associated aseptic meningitis case was defined as an illness of any team or family member with onset during july 28-august 11 with 1) ...201525551596
elucidation of echovirus 30's origin and transmission during the 2012 aseptic meningitis outbreak in guangdong, china, through continuing environmental surveillance.an aseptic meningitis outbreak occurred in luoding city of guangdong, china, in 2012, and echovirus type 30 (echo30) was identified as the major causative pathogen. environmental surveillance indicated that echo30 was detected in the sewage of a neighboring city, guangzhou, from 2010 to 2012 and also in luoding city sewage samples (6/43, 14%) collected after the outbreak. in order to track the potential origin of the outbreak viral strains, we sequenced the vp1 genes of 29 viral strains from cli ...201525616804
lower anti-echovirus antibody responses in children presenting to hospital with asthma exacerbations.rhinoviruses from the enterovirus genus cause frequent infections and induce remarkably high titres of anticapsid antigen antibodies in asthmatics, while the prevalence of neutralising antibodies to the gut-trophic echoviruses from the same genus is diminished.201525640320
is a multivalent hand, foot, and mouth disease vaccine feasible?enterovirus a infections are the primary cause of hand, foot and mouth disease (hfmd) in infants and young children. although enterovirus 71 (ev-a71) and coxsackievirus a16 (cv-a16) are the predominant causes of hfmd epidemics worldwide, ev-a71 has emerged as a major neurovirulent virus responsible for severe neurological complications and fatal outcomes. hfmd is a serious health threat and economic burden across the asia-pacific region. inactivated ev-a71 vaccines have elicited protection again ...201526009802
[genomic characteristics of an echovirus 20 strain (km/ev20/2010) isolated in kunming, yunnan, china].to identify the complete genome sequence of an echovirus 20 isolate (km/ev20/2010) and understand its genetic variation and evolution characteristics.201526080642
echovirus 30 meningitis epidemic followed by an outbreak-specific rt-qpcr.an outbreak of enteroviral aseptic meningitis emerged in southwestern finland in august 2009. the same enterovirus reappeared with increasing incidence of meningitis in other parts of finland in 2010.201526209368
performance evaluation of puritan® universal transport system (unitranz-rt™) for preservation and transport of clinical viruses.the ability of a non-propagating microbial transport medium to maintain the viability of clinically relevant viruses was compared to a similar commercial medium to establish performance equivalence. two dilutions of stock of test viruses, namely adenovirus (adv), cytomegalovirus (cmv), echovirus type 30 (ev), herpes simplex virus (hsv) types 1 and 2, influenza a, parainfluenza 3 (piv), respiratory syncytial virus (rsv), and varicella zoster virus (vzv), were spiked into puritan® medical products ...201526243168
prevalence, type and concentration of human enterovirus and parechovirus in cerebrospinal fluid samples of pediatric patients over a 10-year period: a retrospective study.human enterovirus (ev) and parechovirus (hpev) are significant causes of encephalitis and meningitis in children. the aim of this study was to determine the prevalence, type and viral rna concentration of ev and hpev in cerebrospinal fluid (csf) samples in an unselected cohort of patients <18 years admitted to bonn university hospital from 1998 to 2008.201526607060
enterovirus infections in hospitals of ile de france region over 2013.the monitoring and genotyping of enterovirus (ev) infections can help to associate particular or severe clinical manifestations with specific ev types and to identify the aetiology of infectious outbreaks.201626655266
molecular characterization of echovirus 30 isolates from poland, 1995-2015.echovirus 30 (e30) is one of the most frequently identified enterovirus and a major cause of meningitis in children and adults. to investigate the genetic variability and relationship of e30 isolated from specimens of aseptic meningitis cases that occurred in poland over a period of 20 years, sequences of vp1 gene were determined and genetic analysis was performed. from 1995 to 2015, 124 e30 were isolated using rd cells, and 58 isolates were sequenced and characterized by phylogenetic analysis o ...201626957092
echovirus serotypes circulating in malaysia from 2002 to 2013.to identify the circulating serotypes of human echovirus in malaysia from 2002 to 2013.201626972396
predominance of enterovirus b and echovirus 30 as cause of viral meningitis in a uk population.enteroviruses are the most common cause of aseptic or lymphocytic meningitis, particularly in children. with reports of unusually severe neurological disease in some patients infected with enterovirus d68 in north america, and a recent increase in the number of paediatric enterovirus meningitis cases presenting in this uk midlands population, a retrospective regional surveillance study was performed.201627367546
ev-a71 vaccine licensure: a first step for multivalent enterovirus vaccine to control hfmd and other severe diseases.enteroviruses (evs) are the most common viral agents in humans. although most infections are mild or asymptomatic, there is a wide spectrum of clinical manifestations that may be caused by ev infections with varying degrees of severity. among these viruses, ev-a71 and coxsackievirus (cv) cv-a16 from group a evs attract the most attention because they are responsible for hand, foot and mouth disease (hfmd). other ev-a viruses such as cv-a6 and cv-a10 were also reported to cause hfmd outbreaks in ...201627436364
laboratory diagnosis and genetic analysis of a family clustering outbreak of aseptic meningitis due to echovirus 30.echovirus 30 (e30) is a major pathogen associated with aseptic meningitis. in the summer of 2014, a family clustering aseptic meningitis outbreak occurred in urban-rural fringe of ningbo city in zhejiang province in china. to identify the etiologic agent, specimens were tested by cell culture and reverse transcriptase-polymerase chain reaction. pathogenic examination confirmed that the outbreak is caused by e30. the first case is a 6-year-old child, who studied in kindergarten in local, suffered ...201627646838
molecular identification of human enteroviruses associated with aseptic meningitis in yunnan province, southwest china.human enteroviruses (evs) are the major causative agents of aseptic meningitis. in this study, a total of 524 children were admitted to the children kunming hospital (continental china) for aseptic meningitis manifestations in 2009 and 2010. an ev infection was diagnosed in 85/524 children (16.2 %) and the viruses detected were assigned to 16 serotypes. most serotypes belonged to the enterovirus b species. echovirus 9 was predominant (24.7 %), followed by coxsackievirus b5 (23.5 %) and then echo ...201627652088
molecular epidemiological study of enteroviruses associated with encephalitis in children from hangzhou, china.enterovirus (ev) has over 100 serotypes of species a-d, which can cause various symptoms in infants. enterovirus encephalitis (eve) is serve disease with high morbidity and mortality in children. to well define the epidemiology of eve, we wanted to know more about ev and ev molecular typing by conducting this study in hangzhou.cerebrospinal fluid samples were collected from children with diagnosis of encephalitis. meanwhile, one-step real-time rt-pcr was used for the detection of ev, and we also ...201627749541
large outbreak of herpangina in children caused by enterovirus in summer of 2015 in hangzhou, china.herpangina, usually caused by coxsackie virus a, is prevalent in children spreading through the fecal-oral transmission and the respiratory droplets dissemination. also, it is mostly asymptomatic and self-limiting. in our study, we found that large outbreak of herpangina in children occurred in the summer of 2015 in hangzhou, china. from may 1th to august 31th, a total of 10 210 children were diagnosed with herpangina in children's hospital of zhejiang university school of medicine. 2 310 throat ...201627752104
molecular epidemiological study of enteroviruses associated with encephalitis in children from hangzhou, china.enterovirus (ev) has over 100 serotypes of species a-d, which can cause various symptoms in infants. enterovirus encephalitis (eve) is serve disease with high morbidity and mortality in children. to well define the epidemiology of eve, we wanted to know more about ev and ev molecular typing by conducting this study in hangzhou.cerebrospinal fluid samples were collected from children with diagnosis of encephalitis. meanwhile, one-step real-time rt-pcr was used for the detection of ev, and we also ...201627893696
[epidemiology, etiology and clinical picture of enteroviral meningitis in children in south moravia].enteroviruses (evs) are the most common cause of aseptic viral meningitis. in some cases, they can cause severe meningoencephalitis and acute flaccid paralysis - an association with some virulent serotypes. the objectives were to describe the epidemiological situation of ev meningitis in children in south moravia, to elucidate the etiology including the incidence of virulent serotypes and to evaluate the clinical presentation.201627907970
three cases of mumps virus and enterovirus coinfection in children with enteroviral meningitis.several viruses are responsible for aseptic meningitis; however, in the region of southwest iran, the role played by each virus is still not very well known. the aim of this study is to determine the relative frequencies of mumps virus, herpes viruses, and enteroviruses, as well as coinfections among them, in patients with aseptic meningitis.in this cross-sectional study, samples of cerebrospinal fluid were collected between december 2012 and december 2013 from patients under 14 years, who were ...201627930588
seroepidemiological and phylogenetic characterisation of neurotropic enteroviruses in ireland, 2005-2014.enteroviruses (evs) are associated with a broad spectrum of clinical presentation, including aseptic meningitis (am), encephalitis, hand, foot and mouth disease, acute flaccid paralysis and acute flaccid myelitis. epidemics occur sporadically and are associated with increased cases of am in children. the present study describes the seroepidemiological analysis of circulating evs in ireland from 2005-2014 and phylogenetic characterisation of echovirus 30 (e-30), enterovirus a71 (ev-a71) and enter ...201728071799
sequential transmigration of polymorphonuclear cells and naive cd3(+) t lymphocytes across the blood-cerebrospinal-fluid barrier in vitro following infection with echovirus 30.viral meningitis by non-polio enteroviruses (npev) is a major public health burden causing fatal outcomes especially in the younger population. strong evidence exists that the blood-cerebrospinal-fluid (csf) barrier (bcsfb) serves as an entry point for enterovirus and leucocytes into the central nervous system (cns). moreover, analysis of clinical csf specimens of patients with a npev infection revealed a predominance of polymorphonuclear granulocytes (pmn) in the early phase and mononuclear cel ...201728161477
comparative analysis of viral shedding in pediatric and adult subjects with central nervous system-associated enterovirus infections from 2013 to 2015 in switzerland.several enterovirus (ev) genotypes can result in aseptic meningitis, but their routes of access to the central nervous system remain to be elucidated and may differ between the pediatric and adult populations.201728214758
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