Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| [susceptibility of gram-negative bacterial isolates to six beta-lactam and two aminoglycoside antibiotics at our university hospital]. | susceptibilities of gram-negative bacterial strains isolated at the university hospital in 1987 to six beta-lactam antibiotics (azthreonam cefmetazole, ceftizoxime, latamoxef, aminobenzyl-penicillin and piperacillin) and two aminoglycoside antibiotics (gentamicin and amikacin) were examined by agar dilution and the agar diffusion method. results obtained from both methods correlated well in most of the strains. most of the strains belonging to escherichia coli, klebsiella oxytoca, klebsiella pne ... | 1988 | 3175388 |
| gaps and perspectives of new fluoroquinolones. | the gaps in the present piperazinyl-substituted fluoroquinolones include: (a) gaps in their antibacterial spectrum, varying from one fluoroquinolone to another for streptococci-pneumococci-enterococci (spe), some gram-negative and gram-positive anaerobes, nocardia, pseudomonas maltophilia, ureaplasma urealyticum, slow-growing mycobacteria; (b) a ph dependence of their antibacterial activity (low activity at acidic ph for piperazinyl-substituted fluoroquinolones); (c) a rapid development of bacte ... | 1988 | 3215107 |
| [a clinical evaluation of sultamicillin fine granules in the treatment of meibomianitis]. | this study was performed to evaluate the clinical efficacy and the safety of sultamicillin (sbtpc) fine granules in the treatment of patients with meibomianitis. a dose of 375 mg sbtpc granules was orally given to 10 patients with meibomianitis after each meal, three times a day. the results obtained are summarized as follows. efficacies were rated as good in 7 cases, fair in 2 and poor in 1 with an efficacy ratio of 70.0%. no side effects were observed throughout the study. the organisms isolat ... | 1988 | 3249376 |
| [reconstitution of pseudomonas maltophilia hcg receptor to liposomes by dialysis method]. | 1988 | 3253166 | |
| in vitro activity of cefotaxime against clinically significant pathogens. | the present in vitro antibacterial activities of cefotaxime and 8 other cephalosporins (cefoperazone, cefmenoxime, cefpiramide, latamoxef, cefamandole, cefmetazole, cefotiam and cephazolin) were evaluated simultaneously in 384 strains of gram-positive cocci, 595 strains of enterobacteriaceae, 240 strains of non-fermenters and 143 strains of anaerobes and miscellaneous organisms. the results were expressed as minimum inhibitory concentration (mic) range, mic50 and mic90. of the beta-lactams, cefo ... | 1988 | 3260852 |
| outer membrane permeability and beta-lactamase content in pseudomonas maltophilia clinical isolates and laboratory mutants. | low outer-membrane permeability appears to be responsible for the generally high degree of antibiotic resistance of pseudomonas maltophilia. constitutive overproduction of beta-lactamases affects the sensitivity of these bacteria only to those beta-lactam antibiotics that are hydrolyzed by strain-specific beta-lactamases and that do not efficiently induce these enzymes in inducible strains. | 1988 | 3263685 |
| comparative activity of the 4-quinolones. | minimal inhibitory concentrations (mics) of the 4-quinolones ciprofloxacin, enoxacin, norfloxacin, ofloxacin, pefloxacin, difloxacin, a-56620, and ci-934 are consistent world-wide, with allowances for differences in acquired resistance. mics of these drugs for enterobacteriaceae correlate with those of nalidixic acid, but resistance to the quinolones is rare if a breakpoint of greater than 2 mg/l is accepted. most intestinal pathogens are sensitive. acinetobacter, pseudomonas aeruginosa, and oth ... | 1988 | 3279501 |
| sterility and efficiency of two methods of cardiac output determination: closed loop and capped syringe methods. | a prospective randomized study was done to compare the fluid contamination rates of two methods used to determine cardiac output by thermodilution under in-use conditions. fifty patients were randomly assigned to have cardiac output measured by the capped syringe or closed loop method, and were followed with quantitative cultures of fluid and catheter. the two treatment groups (n = 25 each) were comparable in terms of age, sex, intensive care unit location, underlying diagnosis, and mean number ... | 1988 | 3280519 |
| comparative in vitro activity of a new fluorinated 4-quinolone, t-3262 (a-60969). | the in vitro activity of a new quinolone, t-3262 [a-60969; dl-7-(3-amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1-, 4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid monohydrate], was compared with those of ciprofloxacin, ofloxacin, ceftazidime, imipenem, and gentamicin. t-3262 inhibited 90% of isolates of the family enterobacteriaceae at a concentration of less than or equal to 0.25 micrograms/ml. it was two to four times more active than ofloxacin and similarly or slightly less acti ... | 1988 | 3293524 |
| pseudomonas maltophilia. | 1987 | 3294701 | |
| in vitro activity and beta-lactamase stability of a new monobactam, b0-1165. | b0-1165 is a 1-carboxy-1-cyclopropoxyamino,4-fluoromethyl monobactam. it inhibited the majority of escherichia coli, klebsiella pneumoniae, klebsiella oxytoca, citrobacter diversus, aeromonas hydrophila, proteus mirabilis, proteus vulgaris, providencia rettgeri, providencia stuartii, yersinia enterocolitica, haemophilus influenzae, neisseria gonorrhoeae, and salmonella and shigella species at less than or equal to 0.125 microgram/ml. overall, its in vitro activity was similar to that of aztreona ... | 1987 | 3300528 |
| serological studies in crohn's disease. | elisa and immunofluorescence tests were carried out on sera from patients with crohn's disease and ulcerative colitis. the results indicate that mean antibody levels to yersinia enterocolitica types o:9 and o:3 and klebsiella pneumoniae, but not pseudomonas maltophilia, are significantly higher in these patients than in control subjects. there are differing antibody levels in ileal and colonic disease, and there is a significant fall in antibody levels 9-12 months after remission from clinical s ... | 1987 | 3305007 |
| [comparative activity of ticarcillin-clavulanic acid and various beta-lactams against pseudomonas maltophilia]. | an increase is observed in the isolation of p. maltophilia as a casual agent of nosocomial infection, particularly in hospitalized immunocompromised patients. these infections are associated with the acute problem of their treatment as most of the p. maltophilia strains are generally resistant to many of the commonly used antimicrobial agents, including those active against pseudomonas aeruginosa: beta lactams, aminoglycosides and imipenem. this resistance is correlated with two inducible beta l ... | 1987 | 3309818 |
| in vitro and in vivo antibacterial activities of cs-807, a new oral cephalosporin. | cs-807 is a new oral prodrug of r-3746, a cephalosporin derivative, with potent in vitro and in vivo antibacterial activity against both gram-positive and gram-negative bacteria. the susceptibility of about 1,200 clinical isolates to r-3746 was determined by the agar dilution method. ninety percent or more of pathogens such as staphylococcus aureus, streptococci, escherichia coli, klebsiella pneumoniae, klebsiella oxytoca, indole-positive and indole-negative proteus spp., providencia rettgeri, a ... | 1987 | 3310868 |
| in vitro antibacterial activity and beta-lactamase stability of cl 118523, an aminothiazolyl iminomethoxy cephalosporin. | cl 118523 is an aminothiazolyl cephalosporin which contains a 1, 2, 3-thiadiazol radical at position 3 of the cephem nucleus. it was as active as cefotaxime, ceftazidime and aztreonam against most enterobacteriaceae, mic 90% less than 1 mg/l, and more active, 8 to 32-fold, than cefoperazone and cefoxitin. enterobacter species resistant to the other agents were resistant to cl 118523. cl 118523 did not inhibit pseudomonas aeruginosa, pseudomonas maltophilia, mic greater than 128 mg/l. it had exce ... | 1987 | 3322588 |
| evaluation of pasco mic-id system for identifying gram-negative bacilli. | a production model of the semi-automated pasco mic-id system (pasco laboratories, wheat ridge, colo.) was evaluated with 122 groups or species of gram-negative bacilli, which included typical (499 cultures) and atypical (37 cultures) strains of fermenters and nonfermenters. the pasco system identified 90.9% of 536 cultures accurately; these included 90.8% of 152 nonfermenters, 93.8% of 308 enteric fermenters, and 78.9% of 76 oxidase-positive fermenters. these results were obtained with the aid o ... | 1987 | 3323230 |
| [role of pseudomonas maltophilia and "pseudomonas like bacteria group va" in the etiology of crohn disease]. | in 1976, parent and mitchell isolated cell-wall defective bacteria of the species pseudomonas maltophilia and pseudomonas like bacteria group va from resected bowel tissue of 8 consecutively operated patients with crohn's disease. the control group, which included patients with ulcerative colitis, was negative in this respect. the isolated strains were available for our own investigations. new zealand white rabbits were inoculated with killed bacteria to produce specific antisera. frozen section ... | 1987 | 3326308 |
| in vitro activities of ici 194008 and ici 193428, two new cephem antimicrobial agents. | the in vitro activities of two new cephem antibiotics, ici 193428 and ici 194008, were compared with those of cefpirome, cefotaxime, ceftazidime, and piperacillin. essentially all strains of the family enterobacteriaceae were inhibited by both study drugs at concentrations of less than or equal to 4 micrograms/ml. both new cephems were comparable to ceftazidime against pseudomonas aeruginosa (mic for 90% of strains, 8 micrograms/ml) and were the most active agents tested against pseudomonas malt ... | 1987 | 3326527 |
| injury from silage wagon accident complicated by mucormycosis. | infection due to farm machinery injuries may be caused by microorganisms found in soil or decaying vegetable material. a case of injury due to entrapment of a young boy in a silage wagon is reported here. his injuries were complicated by infection with aspergillus species, absidia species, rhizopus species (the latter two are members of the mucorales order), and pseudomonas maltophilia. successful treatment of his infection followed aggressive surgical debridement of the anterior abdominal wall, ... | 1988 | 3385836 |
| [a study of extraction of hcg binding substances from pseudomonas maltophilia]. | 1988 | 3391593 | |
| synergistic interactions of ciprofloxacin and extended-spectrum beta-lactams or aminoglycosides against multiply drug-resistant pseudomonas maltophilia. | the susceptibility of 28 clinical isolates of pseudomonas maltophilia to 16 antimicrobial agents was determined in vitro by a standard agar dilution method with inoculum sizes of 10(4) and 10(6) cfu. all isolates exhibited multiple drug resistance. nine isolates were selected for studies of combinations of ciprofloxacin with seven antipseudomonal beta-lactams and three aminoglycosides by a checkerboard agar dilution technique. synergistic or additive combinations of ciprofloxacin in clinically a ... | 1988 | 3395107 |
| analysis of the lipopolysaccharide of pseudomonas maltophilia 555. | the phenol phase soluble lipopolysaccharide of pseudomonas maltophilia strain 555, obtained from cells by the hot aqueous phenol method, was of the smooth type. sodium dodecyl sulfate-polyacrylamide gel electrophoresis, hydrolysis, methylation, and 13c and 1h nuclear magnetic resonance analyses showed that this lipopolysaccharide has an o-chain polysaccharide composed of a repeating pentasaccharide unit, containing d-rhamnose (d-rha, one part), 3-acetamido-3,6-dideoxy-d-galactose (d-fuc3nac, one ... | 1987 | 3442630 |
| [study of specific hcg binding to pseudomonas maltophilia]. | 1987 | 3449421 | |
| in vitro activity of ci-934 compared with ciprofloxacin, enoxacin, norfloxacin, and vancomycin. | the in vitro activity of the quinolone ci-934 was compared with ciprofloxacin, norfloxacin, enoxacin, and vancomycin against 607 gram-positive and -negative isolates. ci-934 inhibited 90% of the enterobacteriaceae, aeromonas hydrophila, and acinetobacter spp. at 1 microgram/ml. decreased activity was observed against pseudomonas aeruginosa. pseudomonas maltophilia, and other pseudomonas spp. with ci-934 mic90 greater than or equal to 8 micrograms/ml. ci-934 activity against gram-positive organis ... | 1987 | 3472704 |
| in vitro and in vivo activity of ny-198, a new difluorinated quinolone. | ny-198 [1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3- quinolinecarboxylic acid hydrochloride] is a new difluorinated quinolone characterized by the presence of a c-methyl group at the 3 position of the piperazine moiety. it has a broad antibacterial spectrum. the in vitro antibacterial activity of ny-198 was almost the same as those of ofloxacin and norfloxacin, but far exceeded that of pipemidic acid. ny-198 was more active than norfloxacin against pseudomonas maltophilia ... | 1987 | 3476021 |
| emergence of ofloxacin-resistant citrobacter freundii and pseudomonas maltophilia after ofloxacin therapy. | 1987 | 3478330 | |
| associated mortality and clinical characteristics of nosocomial pseudomonas maltophilia in a university hospital. | we studied the spectrum of clinical disease in 99 patients with nosocomial pseudomonas maltophilia isolates at the university of virginia hospital from 1981 through 1984. the annual rate of isolation increased from 7.1 to 14.1 per 10,000 patient discharges. a crude mortality rate of 43% was documented in all patients from whom the organism was cultured, and the data include 12 patients with nosocomial bacteremia (four deaths). risk factors associated with death for patients having a p. maltophil ... | 1986 | 3487553 |
| antimicrobial activity of ro 15-8074, active metabolite of a new oral cephalosporin (ro 15-8075), against 7,775 recent clinical isolates. | susceptibility testing of 7,775 recent clinical isolates from four medical centers showed ro 15-8074 to be 2-to greater than 8-fold more active than either cefaclor or cefuroxime against the enterobacteriaceae. ro 15-8074 mics for 50% of the strains tested were greater than or equal to 32 micrograms/ml for staphylococcus spp., enterococci, pseudomonas aeruginosa, and pseudomonas maltophilia. beta-lactamase hydrolysis experiments failed to demonstrate significant ro 15-8074 inactivation by common ... | 1986 | 3492961 |
| review of imipenem. | imipenem, a new carbapenem beta-lactam broad-spectrum antibiotic, is highly active in vitro against most aerobic and anaerobic gram-positive and gram-negative bacteria isolated from infectious diseases of human beings. except for enterococci and methicillin-resistant staphylococci most gram-positive cocci are inhibited by less than 2 micrograms/ml. although the mic-90 of methicillin-resistant staphylococci may be less than 4 micrograms/ml, these bacteria are usually resistant to imipenem by modi ... | 1986 | 3519499 |
| imipenem-cilastatin sodium, a broad-spectrum carbapenem antibiotic combination. | the chemistry, antimicrobial spectrum, mechanism of action, pharmacology and pharmacokinetics, clinical use, adverse effects, dosage and administration, place in therapy, cost-effectiveness, and formulary considerations of imipenem-cilastatin sodium are reviewed. imipenem is the first carbapenem antibiotic of the thienamycin class to be used clinically. imipenem has the widest spectrum of antimicrobial activity of currently available beta-lactam agents and, in contrast to other beta-lactam antib ... | 1986 | 3530614 |
| bacterial contamination of ambulance oxygen humidifier water reservoirs: a potential source of pulmonary infection. | the risk and benefit of oxygen humidification during ambulance transport is unknown. we cultured the water in plastic multiple-use bottles of humidifiers on 30 randomly selected area ambulances during november 1985. there were 22 positive cultures. potentially pathogenic bacteria (four pseudomonas maltophilia, three pseudomonas aeruginosa, one klebsiella pneumoniae, and one staphylococcus epidermidis) were found in nine samples. assuming that the water in ambulance humidifiers should have been s ... | 1986 | 3535586 |
| pseudomonas maltophilia exoenzyme activity as correlate in pathogenesis of ecthyma gangrenosum. | ecthyma gangrenosum has not been described during the course of blood stream invasion with pseudomonas maltophilia, although it occurs with a 30% frequency in pseudomonas aeruginosa septicemia. we isolated p. maltophilia from the blood and an ecthyma lesion in a leukemic patient. the organism was an avid protease and elastase producer and hence mimicked the exoenzyme profile of invasive p. aeruginosa. the patient responded to moxalactam to which the isolate was susceptible in vitro. on the basis ... | 1986 | 3537006 |
| in vitro activity against aerobic and anaerobic gram-positive and gram-negative bacteria and beta-lactamase stability of rs-533, a novel carbapenem. | rs-533 is a novel carbapenem antibiotic. its activity was compared with that of imipenem and the new cephalosporins, aztreonam, piperacillin, and tobramycin. rs-533 had activity comparable to that of imipenem, inhibiting the majority of the enterobacteriaceae, streptococci, staphylococci, and bacteroides species at concentrations of less than or equal to 2 micrograms/ml. rs-533 inhibited enterobacter cloacae, citrobacter freundii, and serratia marcescens resistant to ceftazidime, aztreonam, and ... | 1986 | 3545068 |
| infections caused by pseudomonas maltophilia. expanding clinical spectrum. | pseudomonas maltophilia (xanthomonas maltophilia) is a frequently isolated commensal that is gaining increasing recognition as an opportunistic pathogen in debilitated hosts. we report three unusual infections due to p maltophilia that illustrate the ability of the organism to cause life-threatening illness. we describe a case of postoperative meningitis, a case of recurrent bacteremia complicated by ecthyma gangrenosum, and a case of native valve endocarditis in a drug addict. because of freque ... | 1987 | 3632174 |
| pseudomonas maltophilia: an unusual burn wound pathogen. | 1986 | 3639878 | |
| pseudomonas maltophilia. | 1986 | 3700677 | |
| in vitro susceptibility of pseudomonas maltophilia to antimicrobial agents. | reports on the isolation and pathogenicity of some species of gram-negative and glucose-nonfermentative bacilli have appeared in the literature since 1962. the infections caused by those organisms have become important problems as an opportunistic infection in immunosuppressed patients. pseudomonas maltophilia is a glucose-nonfermentative aerobic gram-negative rod widely dispersed in nature. the role of pseudomonas maltophilia as an opportunistic pathogen is not thoroughly established, but a few ... | 1986 | 3702054 |
| [phenotype characteristics of 63 strains of pseudomonas paucimobilis, mostly of hospital origin]. | sixty-three strains of pseudomonas paucimobilis, a gram-negative, lemon yellow pigmented, glucose nonfermenting bacillus are phenotypically compared to the type strain of this new species (atcc 29837). the morphological, cultural, biochemical (onpg-test, oxidase, aesculin positive) and nutritional (assimilation of many glucides) characteristics and susceptibility or resistance to antimicrobial agents (many antibiotics are active) are reported. the similarities and differences between p. paucimob ... | 1986 | 3706830 |
| synthesis of the tetrasaccharide repeating-unit of the lipopolysaccharide isolated from pseudomonas maltophilia. | the title tetrasaccharide having the structure 3-o-me-beta-l-xylp-(1----4)- alpha-l-rhap-(1----4)-alpha-l-rhap-(1----2)-l-rhap was obtained by reaction of the alpha-acetobromo derivative of 4-o-(3-o-methyl-beta-l-xylopyranosyl)-l-rhamnopyranose and benzyl 3,4-di-o-benzyl-2-o-(2,3-o-isopropylidene-alpha-l-rhamnopyranosyl)- alpha-l-rhamnopyranoside, followed by removal of the protecting groups. the synthesised compounds were characterised on the basis of n.m.r. data. | 1986 | 3756956 |
| wounds caused by corn-harvesting machines: an unusual source of infection due to gram-negative bacilli. | the infectious complications in 23 patients with mutilating wounds due to trauma during corn harvesting were compared with those in 41 patients with factory-related hand injuries of similar severity. initial cultures revealed bacterial growth in 89% of the agricultural wounds and in 63% of the factory wounds. a mean of 3.8 initial bacterial species were isolated per corn-harvesting wound vs. 0.9 species per factory wound. gram-negative rods were recovered from 81% of the agricultural wounds; the ... | 1986 | 3797937 |
| the effect of the combination of erythromycin with new beta-lactam antibiotics against gram-negative aerobic respiratory pathogens. | the effect of erythromycin on the in vitro activity of cefotaxime, ceftizoxime, cefoperazone, moxalactam, ceftazidime, cefmenoxime, aztreonam, imipenem, piperacillin, and gentamicin against 89 bacteria isolated from sputum and tracheal aspirates of patients admitted to intensive care units was evaluated. there were 30 pseudomonas aeruginosa, 27 klebsiella pneumoniae, 9 enterobacter cloacae, 5 escherichia coli, 4 enterobacter aerogenes, 3 each of klebsiella oxytoca, pseudomonas maltophilia, serra ... | 1986 | 3802298 |
| formation of halogenated aryl-polyene (xanthomonadin) pigments by the type and other yellow-pigmented strains of xanthomonas maltophilia. | based upon visible electronic absorption spectra and mass spectra, yellow-pigmented strains of xanthomonas maltophilia, including the type strain (icpb 2648-67 = atcc 13637) of this species, were shown to produce aryl-polyene (xanthomonadin) pigments. these pigments, which usually occurred in very small quantities, were isolated and studied as isobutyl derivatives. the most common x. maltophilia pigment (pigment 1), which occurred in 8 of the 12 yellow-pigmented strains examined, was shown to be ... | 1985 | 3833055 |
| the comparative in vitro susceptibility of cefazolin-resistant organisms to six cephalosporins, four penicillins, and three aminoglycosides. | one thousand thirty-seven cefazolin-resistant, gram-negative clinical isolates including members of the family enterobacteriaceae, pseudomonads, and other nonfermenters were tested against a variety of newer antimicrobial agents by microdilution. most of the enterobacteriaceae were resistant to the second-generation cephalosporins, but highly susceptible to the third-generation agents and the broad-spectrum penicillins, 90% of the strains being inhibited at attainable serum concentrations. cefop ... | 1985 | 3851708 |
| in vitro activities of enoxacin, ticarcillin plus clavulanic acid, aztreonam, piperacillin, and imipenem and comparison with commonly used antimicrobial agents. | a total of 745 gram-negative and 313 gram-positive clinical isolates were tested against enoxacin, ticarcillin plus clavulanic acid, aztreonam, imipenem, and piperacillin and compared with commonly used antimicrobial agents. ticarcillin plus clavulanic acid, imipenem, and piperacillin were active against pseudomonas aeruginosa and acinetobacter spp. and most pseudomonas spp. aztreonam was active against members of the family enterobacteriaceae but was less effective against the nonfermenters. en ... | 1985 | 3869433 |
| imipenem (n-formimidoyl thienamycin): in vitro antimicrobial activity and beta-lactamase stability. | in vitro studies with imipenem (n-formimidoyl thienamycin or mk0787) were performed with 8481 clinical isolates in three separate medical centers. more extensive comparative studies were also performed with 605 representative isolates, comparing imipenem to six other beta-lactams. although the newer beta-lactams were often more active against susceptible species, imipenem demonstrated the broadest spectrum of antibacterial activity, with mic 90s less than or equal to 4.0 micrograms/ml for all sp ... | 1985 | 3872196 |
| carbapenems: special properties contributing to their activity. | imipenem is a beta-lactam antibiotic that inhibits most clinical isolates of staphylococci, enterobacteriaceae, and streptococci, excluding enterococci, at 1 microgram/ml or less. resistance can develop in methicillin-resistant staphylococcus aureus, pseudomonas aeruginosa, and serratia marcescens, albeit infrequently. pseudomonas maltophilia is intrinsically resistant to imipenem. many strains of enterobacter cloacae, clostridium freundii, and s. marcescens resistant to the aminothiazolyl cepha ... | 1985 | 3873871 |
| in vitro antibacterial activity of sch 34343 and its stability to beta-lactamases and renal dehydropeptidase 1. | the in vitro antibacterial activity of sch 34343 against 1,328 strains of clinical isolates was compared with those of imipenem and ceftazidime. sch 34343 had a broad spectrum of antibacterial activity against both gram-positive and gram-negative bacteria but was inactive against pseudomonas aeruginosa and pseudomonas maltophilia. sch 34343 was quite stable to hydrolysis by beta-lactamases, including both penicillinases and cephalosporinases. however, sch 34343 was slightly hydrolyzed by a new t ... | 1985 | 3879159 |
| review of the in vitro spectrum of activity of imipenem. | imipenem (n-formimidoyl thienamycin, mk0787), a new carbapenem was found to have the widest antimicrobial activity of currently available beta-lactam drugs. enterobacteriaceae had minimal inhibitory concentrations of imipenem of 8.0 micrograms/ml or less for 99.8 percent of clinical isolates. only rare strains of enterobacter species and proteus mirabilis have higher imipenem minimal inhibitory concentration results. hemophilus and neisseria species were inhibited, but minimal inhibitory concent ... | 1985 | 3890537 |
| prospective randomized comparison of imipenem/cilastatin and cefotaxime for treatment of lung, soft tissue, and renal infections. | thirty-one moderately or severely ill hospitalized patients with proved (25 patients) or suspected (six) bacterial infections were randomly allocated to receive imipenem/cilastatin (16) or cefotaxime (15). the median age, sex, duration of therapy, underlying disease, and types of infection were similar in both groups. nineteen patients with pneumonia, eight with soft tissue infection, and four with acute pyelonephritis were included. the pathogens isolated included escherichia coli (six), strept ... | 1985 | 3901207 |
| imipenem/cilastatin: the first carbapenem antibiotic. | imipenem/cilastatin is the first of a new class of beta-lactam antibiotics called carbapenems. the antibacterial spectrum of imipenem exceeds any antibiotic investigated to date and includes gram-positive, gram-negative, and anaerobic organisms. only methicillin-resistant organisms, strep. faecium, pseudomonas cepacia, and pseudomonas maltophilia have been shown to be resistant. imipenem is administered in a 1:1 ratio with cilastatin, which inhibits a renal enzyme (dehydropeptidase) and improves ... | 1985 | 3910385 |
| volatiles of pseudomonas aeruginosa and related species by automated headspace concentration--gas chromatography. | the volatile metabolites of three strains of pseudomonas aeruginosa and one strain each of pseudomonas cepacia, pseudomonas maltophilia, pseudomonas fluorescens, and pseudomonas putida were analyzed using an automated headspace concentrator incorporating a gas chromatograph. the procedure does not require sample preparation and automates the entire analytical sequence to yield reproducible profiles of volatile constituents. gas chromatographic profiles of the volatile metabolites of each species ... | 1985 | 3924382 |
| transferable amikacin and cefamandole resistance: pseudomonas maltophilia and acinetobacter strains as possible reservoirs of r plasmids. | three strains belonging to gramnegative non-fermenting rods, i.e. a pseudomonas maltophilia strain and two strains of acinetobacter, were tested, as representatives of different types of nosocomial strains, for transferability of their multiple drug resistance. as all of them posed difficulties in demonstrating the transferability of their resistance by conventional methods, a three-step procedure was developed that includes a transfer to rifampicin-resistant p. aeruginosa recipients, then to su ... | 1985 | 3926873 |
| false-resistance of streptococcus faecalis and pseudomonas maltophilia to norfloxacin by disc diffusion susceptibility testing. | 1985 | 3930460 | |
| antibacterial activity of imipenem: the first thienamycin antibiotic. | imipenem (n-formimidoyl thienamycin) is the first representative of a new class of beta-lactam antibiotics--the carbapenems. imipenem has an unusually broad spectrum, high potency, and no cross-resistance with other beta-lactam antibiotics. susceptible gram-negative species include pseudomonas aeruginosa, serratia, and enterobacter. activity is high against staphylococcus aureus, most group d streptococci, and staphylococcus epidermidis but is variable against methicillin-resistant s. aureus. im ... | 1985 | 3931196 |
| multicenter study of the clinical efficacy of imipenem/cilastatin for treatment of serious infections. | the efficacy and safety of imipenem/cilastatin was evaluated in a multicenter study. for 49 of the 78 patients with 79 infections entered into the study, the clinical and bacteriologic efficacy of therapy could be evaluated. toxicity data were analyzed for all 79 infections. overall, 35 of 49 infections were cured or improved: 10 of 11 cases of pneumonia; 8 of 15 cases of pyelonephritis; 4 of 5 cases of osteomyelitis; 3 of 4 intravascular infections; 6 of 9 soft tissue infections; and 4 of 5 mis ... | 1985 | 3931198 |
| the production and molecular properties of the zinc beta-lactamase of pseudomonas maltophilia iid 1275. | the production and purification of a tetrameric zinc beta-lactamase from pseudomonas maltophilia iid 1275 were greatly improved. three charge variants were isolated by chromatofocusing. the subunits each contain two atomic proportions of zinc and (in two of the variants) one residue of cysteine. the thiol group is not required for activity, nor does it appear to bind to the metal. replacement of zinc by cobalt, cadmium or nickel takes place at a measurable rate, and gives enzymes that are less a ... | 1985 | 3931629 |
| amino acid stability and microbial growth in total parenteral nutrient solutions. | the stability of amino acids in total parenteral nutrient (tpn) solutions stored for 30 days and the potential for stored tpn solutions to support growth of microbial contaminants were studied. solutions of 3.5% crystalline amino acids and 25% dextrose with electrolytes were prepared either by using a commercially available amino acid solution with electrolytes or by adding electrolytes individually to a base tpn solution. solutions were stored in polyvinyl chloride bags at refrigerated (4 degre ... | 1985 | 3936355 |
| transferable amikacin resistance in pseudomonas maltophilia and acinetobacter calcoaceticus. | 1985 | 3997255 | |
| effect of temperature on antimicrobial susceptibilities of pseudomonas maltophilia. | after a case of peritonitis caused by pseudomonas maltophilia had occurred 20 strains of the organism were investigated and the minimum inhibitory concentrations of a variety of antibiotics determined at 30 degrees c and 37 degrees c. there was a significant difference in susceptibility between 30 degrees c (most resistant) and 37 degrees c (most susceptible) for aminoglycosides and polymyxin b. no difference was seen with the other agents or in strains of ps aeruginosa and enterobacteriaceae te ... | 1985 | 4044874 |
| synergistic effect of combinations of sulfamethoxazole, trimethoprim, and colistin against pseudomonas maltophilia and pseudomonas cepacia. | eighteen strains of pseudomonas maltophilia and eight strains of p. cepacia were tested for susceptibility to sulfamethoxazole, trimethoprim, and colistin in different combinations. a synergistic effect was found against most of the strains. | 1974 | 4143759 |
| [pseudomonas maltophilia as an agent of infection in man (author's transl)]. | 1974 | 4155214 | |
| isolation of a transducing phage forming plaques on pseudomonas maltophilia and pseudomonas aeruginosa. | 1973 | 4199939 | |
| acute mastoiditis following pseudomonas maltophilia infection: case report. | 1972 | 4337404 | |
| [characterization of pseudomonas maltophilia]. | 1972 | 4553285 | |
| [influence of temperature on the gentamicin effect in pseudomonas maltophilia]. | 1973 | 4695876 | |
| occurrence of branched-cahin hydroxy fatty acids in pseudomonas maltophilia. | three branched-chain hydroxy acids not previously reported in other bacteria were found in extracts from saponified whole cells of pseudomonas maltophilia. on the basis of evidence from mass spectrometry, infrared spectroscopy, and gas chromatographic procedures, they were identified as 2-hydroxy-9-methyldecanoic acid, 3-hydroxy-9-methyldecanoic acid, and 3-hydroxy-11-methyldodecanoic acid. these acids appeared to be tightly bound to other cellular components since they were not extracted from l ... | 1973 | 4712564 |
| production of volatile nitrogenous compounds from the degradation of streptomycin by pseudomonas maltophilia. | ammonia, methylamine, and pyridine were detected in broth filtrates of a streptomycin-degrading strain of pseudomonas maltophilia during growth on streptomycin as a sole carbon and nitrogen source. ammonia and methylamine, quantitatively measured by conversion to chromophores with picryl sulfonic acid, were found to accumulate in broth, whereas pyridine concentration increased in the early stages of streptomycin degradation and then decreased as the degradation of the antibiotic neared completio ... | 1973 | 4752939 |
| pseudomonas maltophilia endocarditis after replacement of the mitral valve: a case study. | 1973 | 4758059 | |
| [pseudomonas maltophilia infections]. | 1974 | 4839507 | |
| diagnostic criteria for differentiation of pseudomonads pathogenic for man. | to determine the most useful diagnostic characters for the differentiation of pseudomonads pathogenic for man, including pseudomonas maltophilia (alcaligenes bookeri), p. stutzeri (bacillus denitrificans), p. pseudomallei (malleomyces pseudomallei), and apyocyanogenic strains of p. aeruginosa, a comparative examination was made of 58 strains of these bacilli for their morphological and biochemical characteristics. it was concluded that the criteria for differentiating these bacteria are type of ... | 1968 | 4879213 |
| an immune-type agglutination of mouse spermatozoa by pseudomonas maltophilia. | 1968 | 4881448 | |
| detection of arginine dihydrolase in nonfermentative gram-negative bacteria by use of thin-layer chromatography. | thin-layer chromatography was used to detect the presence of the arginine dihydrolase system in nonfermentative gram-negative bacteria. the test was positive for the fluorescent pseudomonads as well as pseudomonas maltophilia, whereas other pseudomonas sp., mima, and herellea were negative. this procedure can be completed in a few hours and may be useful in the clinical laboratory. | 1971 | 5137584 |
| bacteremia with and without meningitis due to yersinia enterocolitica, edwardsiella tarda, comamonas terrigena, and pseudomonas maltophilia. | 1970 | 5278130 | |
| pseudomonas maltophilia infections in man. | 1969 | 5766111 | |
| 60co-irradiation as an alternate method for sterilization of penicillin g, neomycin, novobiocin, and dihydrostreptomycin. | the effects of the use of 60co-irradiation to sterilize antibiotics were evaluated. the antibiotic powders were only occasionally contaminated with microorganisms. the d-values of the products and environmental isolates were 0.028, 0.027, 0.015, 0.046, 0.15, 0.018, and 0.19 mrads for aspergillus species (uc 7297, 7298), a. fumigatus (uc 7299), rhodotorula species (uc 7300), penicillium oxalicum (uc 7269), pseudomonas maltophilia (uc 6855), and a biological indicator microorganism, bacillus pumil ... | 1983 | 6186803 |
| the interaction of brucella cell surface components with plant agglutinins. | cells of all brucella species were agglutinated by the basic protein-reactive lectins of mangifera indica and persea americana. cells of non-smooth strains including b. ovis and b. canis but not smooth strains were also agglutinated by concanavalin a. these lectins also reacted in a similar pattern with lipopolysaccharide extracts of these organisms. the lectin from bandeiraea simplicifolia precipitated with the lipopolysaccharide antigens of smooth brucella organisms and with those of serologic ... | 1984 | 6208071 |
| in vitro activity of norfloxacin, a quinolinecarboxylic acid, compared with that of beta-lactams, aminoglycosides, and trimethoprim. | norfloxacin is a quinolinecarboxylic acid compound. we examined the in vitro activity of this compound against gram-positive and -negative species, including anaerobic species. it inhibited 90% (mic90) of strains of escherichia coli at 0.05 microgram/ml, klebsiella sp. at 0.4 microgram/ml, salmonella and shigella spp. at 0.1 microgram/ml, citrobacter sp. at 0.4 microgram/ml, enterobacter cloacae at 0.2 microgram/ml, enterobacter aerogenes at 0.4 microgram/ml, and enterobacter agglomerans at 0.2 ... | 1982 | 6214995 |
| comparative in vitro activity of norfloxacin against urinary tract pathogens. | the in vitro activity of norfloxacin (mk366) against 477 aerobic gram-negative and gram-positive clinical isolates was compared to that of nalidixic acid, nitrofurantoin, ampicillin, cephalexin, trimethoprim, sulfamethoxazole, and the combination trimethoprim-sulfamethoxazole. norfloxacin was more active than the other agents against all gram-negative organisms tested. minimal inhibitory concentrations (mics) of pseudomonas aeruginosa were less than or equal to 0.125-32 mg/l with 90% inhibited ( ... | 1983 | 6224679 |
| [exogenous orthophosphate regulation of the phosphohydrolase activities of pseudomonas aeruginosa and pseudomonas maltophilia]. | the activity of several phosphohydrolases, viz. alkaline phosphatase (ec 3.1.3.1), acid phosphatase (ec 3.1.3.2), atpase (ec 3.6.1.3), tripolyphosphatase (ec 3.6.1.2) and polyphosphatase (ec 3.6.1.11), was studied in pseudomonas aeruginosa vkm b-889 and pseudomonas maltophilia vkm b-591. in the absence of orthophosphate in the medium when alkaline phosphatase was derepressed, its activity in p. aeruginosa rose in parallel with that of acid phosphatase, tripolyphosphatase and polyphosphatase. the ... | 1981 | 6276704 |
| lymphocyte transformation to specific antigens associated with crohn's disease. | specific lymphocyte transformation to three micro-organisms that have been implicated in crohn's disease was performed. these were pseudomonas maltophilia, mycobacterium kansasii and rotavirus. no significant differences were observed for any of the antigens tested. simultaneous testing of nonspecific stimulation by pha also showed no difference between patients and controls. these results do not support an aetiological role for these organisms mediated by a purely cellular mechanism. | 1981 | 6284623 |
| susceptibility of 324 nonfermentative gram-negative rods to 6 cephalosporins and azthreonam. | susceptibility of 324 isolates of nonfermentative gram-negative bacteria to cephalothin, cefamandole, cefoxitin, ceftazidime, cefsulodin, and azthreonam was determined by agar dilution and disc diffusion techniques. with the exception of moraxella species, first- and second-generation cephalosporins were minimally active against nonfermenters tested. cefsulodin and azthreonam were mainly active against pseudomonas aeruginosa. in contrast, ceftazidime and ceftriaxone exhibited wider activity spec ... | 1983 | 6311492 |
| susceptibility of gram-negative bacteria to polymyxin b nonapeptide. | subinhibitory concentrations of polymyxin b nonapeptide sensitized all 21 polymyxin-susceptible gram-negative bacterial strains studied to hydrophobic antibiotics such as fusidic acid, novobiocin, and erythromycin. the susceptibility increases were usually 30- to 300-fold. the strains included representatives of escherichia coli with different o- and k-antigens, klebsiella pneumoniae, klebsiella oxytoca, enterobacter cloacae, enterobacter agglomerans, salmonella typhimurium, acinetobacter calcoa ... | 1984 | 6331296 |
| purification of beta-lactamases by affinity chromatography on phenylboronic acid-agarose. | several beta-lactamases, enzymes that play an important part in antibiotic resistance, have been purified by affinity chromatography on boronic acid gels. the procedure is rapid, appears to be selective for beta-lactamases, and allows a one-step purification of large amounts of enzyme from crude cell extracts. we have found the method useful for any beta-lactamase that is inhibited by boronic acids. two kinds of boronic acid column have been prepared, the more hydrophobic one being reserved for ... | 1984 | 6332621 |
| micromethod for carbon substrate assimilation by pseudomonas maltophilia. | assimilation of 60 carbon sources by 114 pseudomonas maltophilia strains, identified by conventional methods, was studied by a standardized micromethod (api strip). automatic reading of growth intensity was done at 1, 2 and 4 days. growth kinetics of reference strain nctc 10257 were also studied and showed evidence of different growth according to the substrates. the results agreed well with nutritional patterns reported. this micro-method seems suitable for daily use by laboratories because of ... | 1983 | 6362276 |
| in vitro activity of imipenem--a review. | a review is given of the microbiological properties of imipenem, a new carbapenem antibiotic with an exceptionally broad spectrum of antibacterial activity. an evaluation of results of numerous in vitro studies reveals that imipenem effectively inhibited growth of 53 of 55 bacterial species, the mean mic90 being less than 8 mg/l. the mic90 for cocci, with the exception of staphylococcus epidermidis, is in the range of 0.01-3.1 mg/l. the mic90 for all enterobacteriaceae is equal to or less than 8 ... | 1984 | 6389125 |
| association of pseudomonas maltophilia with malignant lesions. | infections caused by nonfermentative, gram-negative, rod-shaped bacteria (nfgnr) in 564 patients were reviewed. for comparison, 227 patients with serratia marcescens infections were also studied. among the patients with nfgnr infections, 24% had some form of malignant solid tumor, and 9% had leukemia and lymphoma. among the patients with s. marcescens infections, 22% had some type of malignant solid tumor, and 8% had leukemia and lymphoma. the frequency of various species of nfgnr (except pseudo ... | 1984 | 6392316 |
| collaborative evaluation of the abbott avantage system for identification of frequently isolated nonfermentative or oxidase-positive gram-negative bacilli. | the capability of the abbott avantage system to identify 10 species of commonly isolated glucose nonfermentative or oxidase-positive gram-negative bacilli in a 5-h test period was evaluated in a collaborative study. the avantage nonenteric data base uses 20 biochemical test reactions performed in an expanded abbott bacterial identification cartridge plus the results of a manual oxidase test. the species included in the avantage data base are acinetobacter anitratus, acinetobacter iwoffi, aeromon ... | 1984 | 6392323 |
| moxalactam (ly127935), a new semisynthetic 1-oxa-beta-lactam antibiotic with remarkable antimicrobial activity: in vitro comparison with cefamandole and tobramycin. | moxalactam (ly127935) exhibited greater in vitro activity than cefamandole and tobramycin against clinical isolates of enterobacteriaceae, aeromonas hydrophila, and pseudomonas maltophilia. the activities of the three drugs against other microorganisms were as follows: for staphylococci, cefamandole = tobramycin greater than moxalactam; for streptococci, cefamandole greater than moxalactam greater than tobramycin; and for pseudomonas aeruginosa, tobramycin greater than moxalactam greater than ce ... | 1980 | 6446880 |
| piperacillin in surgical infections: a clinical trial. | piperacillin was administered in eighteen patients with mixed infections. three had osteomyelitis, two had peritonitis, two had gangrenous toes, one had bronchopneumonia, and the other ten had leg ulcers of various types accompanies by cellulitis. in eleven patients one of the infecting organisms was pseudomonas aeruginosa, and another had pseudomonas maltophilia. all had appropriate surgical treatment, which in nine patients included skin grafting in the presence of pseudomonas aeruginosa. all ... | 1981 | 6460496 |
| observations on serological cross-reactions between smooth brucella species and organisms of other genera. | serological cross-reactions have been demonstrated between smooth brucella species and escherichia coli 0:116 and 0:157, salmonella serotypes of kauffmann-white group n, pseudomonas maltophilia and yersinia enterocolitica 0:9 and 0:16. all of these organisms may evoke significant titres of cross-reacting antibodies in cattle and pigs inoculated by parenteral routes. e. coli 0:157, salmonella urbana and y. enterocolitica 0:9 evoked substantial titres of cross-reacting antibodies in cattle inocula ... | 1984 | 6489620 |
| pseudomonas maltophilia endocarditis. | 1984 | 6534862 | |
| direct dilution sampling, quantitation, and microbial assessment of open-system ventilation circuits in intensive care units. | in a systematic approach, 37 duplicate samples of open system circuits (bennett ma-1 ventilators) of patients in medical and surgical intensive care units were processed by direct and serial (apha guidelines) dilutions. the paired difference test on 15 of the in-use circuitry solution samples indicated no difference between the direct and serial dilution methods (p less than 0.001). seventy-seven additional respiratory therapy circuitry samples from similar intensive care patients were analyzed ... | 1983 | 6575015 |
| in vitro antibacterial activity of sm-1652, a new broad-spectrum cephalosporin with antipseudomonal activity. | sm-1652 (sodium 7-[d(-)-alpha-(4-hydroxy-6-methylpyridine-3-carboxamido)-alpha-(4-hydroxyphenyl)acetamido]-3-[(1-methyl-1h-tetrazol-5-yl) thiomethyl]-3-cephem-4-carboxylate) is a new semisynthetic cephalosporin derivative with a broad spectrum of antibacterial activity. its in vitro activity against gram-positive bacteria was comparable to that of cefazolin. sm-1652 exceeded cefazolin in potency and broadness of antibacterial activity against such enterobacteriaceae as indole-positive proteus sp ... | 1983 | 6601470 |
| in-vitro and in-vivo antibacterial activity of imipenem against clinical isolates of bacteria. | imipenem, a derivative of thienamycin, a carbapenem antibiotic, has a broad spectrum of activity against aerobic (gram-positive and gram-negative) and anaerobic bacteria. it is quite stable to all tested beta-lactamases produced by various species of bacteria isolated from clinical specimens, whether plasmid or chromosomally mediated. one exception is its hydrolysis by the beta-lactamase produced by pseudomonas maltophilia which is thus usually resistant to imipenem. imipenem was found to be hyd ... | 1983 | 6607914 |
| purification and properties of an inducible cephalosporinase from pseudomonas maltophilia gn12873. | an inducible cephalosporinase was purified from pseudomonas maltophilia gn12873. the pi was 8.4, and the molecular weight was ca. 56,000 by gel filtration or 27,000 by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, suggesting that this enzyme had two subunits. the optimal ph and optimal temperature were 7.5 and 45 degrees c, respectively. enzyme activity was inhibited by clavulanic acid, sulbactam, cephamycin derivatives, carbapenem antibiotics, iodine, hgcl2, and p-chloromercuribenz ... | 1984 | 6609682 |
| co-trimoxazole use for resistant pseudomonas maltophilia. | 1984 | 6610525 | |
| comparative in vitro activities of third-generation cephalosporins. | the in vitro susceptibilities of 823 clinical isolates to eight third-generation cephalosporin and cephalosporinlike antibiotics were studied. all eight antibiotics were more active and had broader spectrums of activity against gram-negative bacilli and anaerobes than older derivatives; however, they were less active against gram-positive cocci. cefotaxime sodium, cefmenoxime hydrochloride, ceftriaxone disodium, and ceftizoxime sodium had similar activities. cefoperazone sodium was more active t ... | 1983 | 6615095 |
| serratia ficaria isolated from a leg ulcer. | serratia ficaria was isolated from culture of a leg ulcer of a 44-year-old woman who had venous insufficiency and alcoholic cirrhosis. although pseudomonas maltophilia, p acidovorans, and enterobacter cloacae were also present, s ficaria was isolated in large numbers and was considered to contribute significantly to this infection. this represents the third known clinical isolation of this bacterium. | 1983 | 6648629 |
| synergy with double and triple antibiotic combinations compared. | combinations of two sets of antibiotics (gentamicin-carbenicillin-rifampicin and trimethoprim/sulphamethoxazole-carbenicillin-rifampicin) were tested against isolates of pseudomonas maltophilia. an abbreviated checker-board method permitted tests with combinations of all three antibiotics and of each of the possible three pairs in each set. triple combinations were usually synergistic, whereas 25% of combinations of pairs were antagonistic or additive. the modal degree of synergy was greater wit ... | 1983 | 6662835 |
| isolation of pseudomonas maltophilia from human stools with thienamycin. | p. maltophilia, a thienamycin-resistant species, was isolated by means of thienamycin-blood agar (10 mg/l) from 14 out of 218 stools. macconkey agar with thienamycin was inhibitory for part of the strains. | 1983 | 6675350 |