Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| the identification of nocardia asteroides and nocardia brasiliensis. | 1961 | 13704444 | |
| schema for the differentiation of nocardia asteroides and nocardia brasiliensis. | 1959 | 13802253 | |
| [isolation of nocardia brasiliensis and asteroides from soils]. | 1960 | 13900235 | |
| [from nocardioses and mycetomas to nocardia steroides and nocardia brasiliensis]. | 1962 | 13933054 | |
| mycetomas caused by nocardia brasiliensis; with a note on the isolation of the causative organism from soil. | 1962 | 13939425 | |
| mycetoma by nocardia brasiliensis. isolation of the agent from soils. | 1962 | 13949039 | |
| precipitin and skin tests in the diagnosis of mycetoma due to nocardia brasiliensis. | 1963 | 13968566 | |
| immunologically active polysaccharides from nocardia asteroides and nocardia brasiliensis. | zamora, a. (university of mexico, mexico, d.f.), l. f. bojalil, and fernando bastarrachea. immunologically active polysaccharides from nocardia asteroides and nocardia brasiliensis. j. bacteriol. 85:549-555. 1963.-two immunologically active polysaccharides were isolated from nocardia asteroides (poly i na and poly ii na) and n. brasiliensis (poly i nb and poly ii nb). these polysaccharides were isolated from cell extracts and purified by methanol precipitation, chloroform extraction of extraneou ... | 1963 | 14042932 |
| nocardia brasiliensis in new england. | 1964 | 14062127 | |
| disseminated nocardiosis caused by nocardia brasiliensis. first case report in the united states. | 1964 | 14096366 | |
| mycetoma in north india due to nocardia brasiliensis. first report of n. brasiliensis from asia. | 1964 | 14187897 | |
| [isolation of a new alcohol, 16-hentriacontanol from the lipids of nocardia brasiliensis]. | 1964 | 14222640 | |
| [mycetoma of the foot caused by "nocardia brasiliensis"]. | 1965 | 14322366 | |
| mycetoma (nocardia brasiliensis). | 1965 | 14329245 | |
| [sulfisoxazol in the treatment of mycetomas caused by nocardia brasiliensis]. | 1962 | 14466437 | |
| [characteristics of nocardia asteroides and nocardia brasiliensis in tissue cultures]. | 1961 | 14487038 | |
| in vitro activities of new antimicrobials against nocardia brasiliensis. | the in vitro sensitivities of 30 strains of nocardia brasiliensis to da-7867, gatifloxacin, moxifloxacin, and bms-284756 (garenoxacin) were determined using the broth microdilution method. all n. brasiliensis strains were sensitive to these antimicrobials. the most active drug in vitro was da-7867, with a mic at which 90% of the isolates tested were inhibited of 0.03 micro g/ml and a mic at which 50% of the isolates tested were inhibited of 0.06 micro g/ml. | 2004 | 14742215 |
| in vitro and in vivo activities of antimicrobials against nocardia brasiliensis. | in mexico mycetomas are mostly produced by nocardia brasiliensis, which can be isolated from about 86% of cases. in the present work, we determined the sensitivities of 30 n. brasiliensis strains isolated from patients with mycetoma to several groups of antimicrobials. as a first screening step we carried out disk diffusion assays with 44 antimicrobials, including aminoglycosides, cephalosporins, penicillins, quinolones, macrolides, and some others. in these assays we observed that some antimicr ... | 2004 | 14982772 |
| absolute stereochemistry of immunosuppressive macrolide brasilinolide a and its new congener brasilinolide c. | brasilinolide a (2) is a 32-membered polyhydroxyl macrolide with immunosuppressive activity isolated from a pathogenic actinomycete, nocardia brasiliensis ifm0406. the absolute configurations at 26 chiral centers of 2 and its new congener, brasilinolide c (1), were determined on the basis of the spectral data of 1 and degradation products derived from 1 and 2. | 2004 | 14987008 |
| nocardia tenerifensis sp. nov. | a gram-positive, non-spore-forming bacterium (gw39-1573(t)) was isolated from soil of the spanish island of tenerife. 16s rrna gene sequence similarity studies showed that strain gw39-1573(t) belonged to the genus nocardia and was most closely related to nocardia brasiliensis (98.0 %), nocardia beijingensis (97.3 %), nocardia transvalensis (97.5 %), nocardia asteroides (97.2 %) and nocardia farcinica (97.0 %). strain gw39-1573(t) could be distinguished from all other validly described nocardia s ... | 2004 | 15023947 |
| disseminated nocardiosis masquerading as abdominal tuberculosis. | a 32-year-old patient was admitted with a community-acquired pneumonia. she had clinical evidence of aids and chest x-ray features consistent with pulmonary tuberculosis. while in the ward she developed an acute abdomen necessitating laparotomy, at which a diagnosis of abdominal tuberculosis was made. sputum and intraoperative pus specimens grew a multiresistant nocardia brasiliensis. microbiological investigations for tuberculosis were negative. the patient died after a short icu admission from ... | 2004 | 15181710 |
| nocardial infection in immunosuppressed kidney transplant recipients. | nocardiosis is a very rare, opportunistic infection caused by microorganisms of the genus nocardia, and is associated with significant morbidity and mortality in kidney transplant patients receiving immunosuppressive therapy. | 2004 | 15204409 |
| nocardia brasiliensis cellulitis in a heart transplant patient. | three months after undergoing heart transplantation, a 55-year-old man presented with n. brasiliensis cellulitis resulting from a splinter wound acquired during yard work. surgical débridement was necessary before the infection responded to medical treatment. although pulmonary nocardiosis is a well-documented complication of immunosuppressive therapy, this is the 1st report of a nocardial infection associated with primary skin involvement in a heart transplant patient. | 1990 | 15227399 |
| actinomycetoma caused by nocardia brasiliensis. | 2004 | 15330073 | |
| primary nocardia brasiliensis of the eyelid. | to report a rare case of lymphocutaneous nocardia brasiliensis originating in the eyelid. | 2004 | 15364245 |
| humoral immunity through immunoglobulin m protects mice from an experimental actinomycetoma infection by nocardia brasiliensis. | an experimental model of infection with nocardia brasiliensis, used as an example of a facultative intracellular pathogen, was tested. n. brasiliensis was injected into the rear foot pads of balb/c mice to establish an infection. within 30 days, infected animals developed a chronic actinomycetoma infection. batch cultures of n. brasiliensis were used to purify p61, p38, and p24 antigens; p61 is a catalase, and p38 is a protease with strong caseinolytic activity. active and passive immunizations ... | 2004 | 15385456 |
| brasilicardins b-d, new tricyclic terpenoids [correction of terpernoids] from actinomycete nocardia brasiliensis. | three new tricyclic terpenoids, brasilicardins b-d (2-4), were isolated together with brasilicardin a (1), a potent immunosuppressive compound, from the cultured broth of a pathogenic actinomycete nocardia brasiliensis ifm0406, and the structures and stereochemistry were determined by spectroscopic data and a single crystal x-ray diffraction analysis. the immunosuppressive and cytotoxic activities of 2-4 were examined in the comparison with 1. | 2004 | 15465331 |
| primary lymphocutaneous nocardiosis in an immunocompetent patient. | nocardia brasiliensis is a rare human pathogen usually associated with localized cutaneous infections. | 2004 | 15544704 |
| cytokine production and lymphocyte proliferation in patients with nocardia brasiliensis actinomycetoma. | ifn-gamma, tnf-alpha, il-4, il-10 and il-12 concentrations in the supernatant of peripheral blood mononuclear cell (pbmc) cultures and the in vitro proliferation of pbmc were studied in 25 patients with actinomycetoma caused by nocardia brasiliensis and in 10 healthy controls from endemic zones. cell cultures were stimulated by a n. brasiliensis crude cytoplasmic antigen (nb) and five semi-purified protein fractions (nb2, nb4, nb6, nb8, and nb10) separated by isoelectric. phytohemagglutinin (pha ... | 2004 | 15630549 |
| nocardia takedensis sp. nov., isolated from moat sediment and scumming activated sludge. | chemotaxonomic and morphological characterization of two actinomycete strains, ms1-3t and as4-2, respectively isolated from moat sediment and scumming activated sludge, was carried out. this characterization clearly demonstrated that strains ms1-3t and as4-2 belong to the genus nocardia. 16s rrna gene sequencing studies showed that these isolates are most closely related to nocardia beijingensis (98.1-98.3 % similarity), nocardia brasiliensis (97.9-98.0 %) and nocardia tenerifensis (97.8-97.9 %) ... | 2005 | 15653914 |
| clinical isolates of nocardia brasiliensis from japan exhibit variable susceptibility to the antibiotic imipenem. | clinical isolates of nocardia brasiliensis from japan were classified into two groups based on their susceptibility to the carbapenem antibiotic, imipenem (ipm). of 33 strains tested, 10 belonged to an ipm susceptible group, with mic of from 0.25 to 2 microg/ml and a mic(80) value of 1.5 microg/ml for this antibiotic. the remaining 23 strains belonged to an ipm resistant group with mic and mic(80) values of 8-16 microg/ml and >16 microg/ml, respectively. the type strain of n. brasiliensis belong ... | 2004 | 15702268 |
| [immunoglobulins in patients with nocardia brasiliensis actinomycetoma]. | considering that some authors have reported an increasing of some immunoglobulins in actinomycetoma patients, in this study we propose to determine differential production of igg1, igg2, igg3, igg4 and iggm in 25 patients with actinomycetoma and 25 healthy individuals from a mycetoma endemic area. immunoglobulins were determined by elisa technique. to sensibilize the plates, six nocardia brasiliensis antigens were used: a crude antigen denominated nb and five derivatives (nb2, nb4, nb6, nb8 and ... | 2004 | 15786870 |
| brasilibactin a, a cytotoxic compound from actinomycete nocardia brasiliensis. | a new cytotoxic compound, brasilibactin a (1), has been isolated from the actinomycete nocardia brasiliensis ifm 0995, and the structure was elucidated on the basis of spectroscopic data and chemical means. | 2005 | 15787462 |
| primary cutaneous nocardiosis due to nocardia brasiliensis in an immunocompetent patient. | 2005 | 15863876 | |
| successful treatment of a disseminated nocardia brasiliensis infection. | 2005 | 15889299 | |
| [multiple cerebral abscess caused by nocardia brasilientis]. | streptococcus aureus, streptococci, and enterobacteria were major causative agents of abscesses of the brain. at present, associated infection is responsible for 60% of cerebral abscesses. when systemic and specific immunities are diminished, a risk for cerebral abscesses caused by fungi increases. among them, there are the most common fungi candida species or aspergillus species. the paper gives an example of successful complex treatment of multiple cerebral abscesses caused by an association o ... | 2005 | 15912868 |
| primary cutaneous nocardiosis in 2 patients on immunosuppressants. | two female cases of primary cutaneous nocardiosis due to nocardia brasiliensis are described. the first was associated with polymyositis and the second with chronic immune thrombocytopenic purpura. both patients had received corticosteroids. in both cases the responsible actinomycetes were sensitive to trimethoprim/sulfamethoxazole. this drug was administered to both patients with excellent results. treatment was continued for 3 months to prevent recurrence, a common consequence of short-term th ... | 2005 | 16012014 |
| a case of nocardiosis with an uncharacteristically long incubation period. | we report a case of an immunocompetent man with a 4-year history of persistent pruritic lesions along the long axis of his forearm. the symptoms began 3 years after the patient immigrated to new york from mexico. a histopathologic evaluation demonstrated primary cutaneous nocardiosis. this rare case of nocardia brasiliensis infection in a nontropical area raises the possibility that the incubation period for nocardia may be longer than previously believed. alternatively, cutaneous nocardiosis ma ... | 2005 | 16144286 |
| [nocardia brasiliensis leg ulcer and nodular lymphangitis in france]. | nocardia brasiliensis is a very rarely reported cause of chronic phagedenic ulcerations. we report the case of an elderly woman who developed such an infection after falling on her right leg on the road in the bresse country (an essentially agricultural and bovine-cattle breading region) and developed a chronic phagedenic ulcer secondarily complicated by nodular lymphangitis of the thigh. | 2005 | 16230921 |
| a fatal pulmonary infection by nocardia brasiliensis. | the reported case is of primary pulmonary nocardiosis, caused by nocardia brasiliensis, in a immunocompromised patient, which ended fatally despite appropriate treatment. the partially acid fast filamentous bacterium was predominant on direct examination of the sputum. it was cultured on blood agar, macconkey agar and by paraffin baiting technique. the bacterium was resistant to cotrimoxazole, the drug of choice for nocardiosis. | 2006 | 16505561 |
| immunochemistry of the group-specific polysaccharide of nocardia brasiliensis. | estrada-parra, sergio (escuela nacional de ciencias biológicas, méxico, d.f., méxico), abel zamora, and l. f. bojalil. immunochemistry of the group-specific polysaccharide of nocardia brasiliensis. j. bacteriol. 90:571-574. 1965.-the group-specific polysaccharide of nocardia brasiliensis was further purified, yielding an amorphous white material with the following characteristics: [alpha](d) (20) = + 48; nitrogen, 0.5%; phosphorus, 0.1%; and ash as sodium, 0.8%. the polymer is made of d-arabinos ... | 1965 | 16562050 |
| [clinical and microbiological study of mycetomas at the muñiz hospital of buenos aires between 1989 and 2004]. | this work presents clinical, microbiological and outcome data collected from 76 patients with mycetomas at the muñiz hospital from 1989 to 2004. forty-nine patients were male and 27 female; the mean age was 43.4 years. the majority of the patients acquired the infection in argentina: the most affected provinces were santiago del estero with 31 cases, and chaco with 11; 8 cases came from other countries (bolivia 6 and paraguay 2). the mean evolution of the disease was 9.2 years. the most frequent ... | 2006 | 16784127 |
| determination of antimicrobial susceptibility patterns of nocardia spp. from clinical specimens by etest. | susceptibilities to 11 antimicrobial agents were determined by etest for 93 nocardia isolates from clinical specimens and 15 type strains belonging to different nocardia spp. all isolates were susceptible to trimethoprim-sulphamethoxazole, amikacin and linezolid, but susceptibilities of the various nocardia spp. to beta-lactams, aminoglycosides, ciprofloxacin and clarithromycin varied markedly. overall, there was a good correlation between the drug resistance patterns and the species identificat ... | 2006 | 16882297 |
| immunogenicity is unrelated to protective immunity when induced by soluble and particulate antigens from nocardia brasiliensis in balb/c mice. | cell-mediated immunity plays a major role in protection against intracellular microbes. nocardia brasiliensis is a facultative intracellular pathogen that causes chronic actinomycetoma. in this work, we injected balb/c mice with soluble p24 and particulate antigens from n. brasiliensis. a higher antibody titer and lymphocyte proliferation was induced by the particulate antigen than by the soluble antigen. however, five months after antigen injection, antibody concentration and lymphocyte prolife ... | 2006 | 16935541 |
| in vitro activities of da-7157 and da-7218 against mycobacterium tuberculosis and nocardia brasiliensis. | the in vitro activities of da-7157, a novel oxazolidinone, against clinical isolates of nocardia brasiliensis and mycobacterium tuberculosis were determined. equal mic(50)s and mic(90)s (0.25 and 0.5 microg/ml, respectively) were found for susceptible and multidrug-resistant isolates of m. tuberculosis. the n. brasiliensis isolates showed an mic(90) of 1 microg/ml and an mic(50) of 1 microg/ml. the da-7157 prodrug, da-7218, exhibited similar mics for m. tuberculosis but fivefold-higher mics for ... | 2006 | 16940121 |
| mycetoma in children: experience with 15 cases. | mycetoma is a chronic infection caused by aerobic actinomycetes and filamentous fungi. it is an occupational disease frequent in tropical countries and is uncommon in children. | 2007 | 17195706 |
| treatment of actinomycetoma due to nocardia spp. with amoxicillin-clavulanate. | actinomycetoma is a chronic occupational condition that occurs frequently in tropical regions. in mexico 85% of cases are caused by nocardia brasiliensis. there are two treatments of choice for these cases: a regimen of dapsone plus trimethoprim-sulfamethoxazole (co-trimoxazole) and, recently, amikacin, either alone or combined. however, not all cases respond properly to these therapies. | 2007 | 17223871 |
| thiols in nitric oxide synthase-containing nocardia sp. strain nrrl 5646. | mycothiol (msh) [1-d-myo-inosityl-2-(n-acetyl-l-cysteinyl)amido-2-deoxy-alpha-d-glucopyranoside], isolated as the bimane derivative, was established to be the major thiol in nocardia sp. strain nrrl 5646, a species most closely related to nocardia brasiliensis strain dsm 43758(t). thiol formation and detection of msh-dependent formaldehyde dehydrogenase activity in cell extracts are relevant to the possible modulation of nitric oxide toxicity generated by strain nrrl 5646. | 2007 | 17337559 |
| clinical and microbiological features of nocardiosis 1997-2003. | nocardiosis has been believed to be caused by the members of the nocardia asteroides complex and the nocardia brasiliensis species. however, recent advances in genotypic identification have shown that the genus exhibits considerable taxonomic complexity and the phenotypic markers used in the past for its identification can be ambiguous. the aim of this study was to assess the species distribution of nocardia isolates and to determine whether there are differences in pathogenicity or antimicrobia ... | 2007 | 17374898 |
| risk factors, clinical characteristics, and outcome of nocardia infection in organ transplant recipients: a matched case-control study. | risk factors for nocardia infection in organ transplant recipients have not been formally assessed in the current era of transplantation. | 2007 | 17443467 |
| expression of nocardia brasiliensis superoxide dismutase during the early infection of murine peritoneal macrophages. | nocardia brasiliensis is the main agent of actinomycetoma in mexico, but little is known about its virulence and molecular pathogenic pathways. these facultative intracellular bacteria are able to survive and divide within the host phagocytic cells, in part by neutralizing the reactive oxygen intermediates. superoxide dismutase (sod) participates in the intracellular survival of several bacterial species and, in particular, constitutes one of nocardia asteroides virulence factors. to clarify sod ... | 2006 | 17473895 |
| nocardial infections: report of 22 cases. | twenty-two cases of nocardial infections were diagnosed in our city between 1977- 1998. all patients whose clinical specimens showed nocardia spp. at gram stain, which were further confirmed by culture, were selected to be included in the study. data from patients who were cured were compared with those from patients who died by statistical tests using epiinfo version 6.04 software. six isolates were identified as nocardia asteroides complex, one as nocardia asteroides sensu stricto and other as ... | 2007 | 17823754 |
| nocardia brasiliensis in italy: a nine-year experience. | in the past, no case reports concerning n. brasiliensis infections were published from italy. we now report 4 cases observed during 1998-2006 in 4 italian patients, 1 immunosuppressed and 3 immunocompetent. | 2007 | 18027278 |
| [lymphocutaneous syndrome due to nocardia brasiliensis in an immunocompetent patient]. | 2008 | 18208769 | |
| efficacy of da-7218, a new oxazolidinone prodrug, in the treatment of experimental actinomycetoma produced by nocardia brasiliensis. | two recently synthesized oxazolidinones: (r)-3-(4-(2-(2-methyltetrazol-5-yl)-pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one (da-7157) and its corresponding pro-drug (r)-3-(4-(2-(2-methyltetrazol-5-yl)-pyridin-5-yl)-3-fluorophenyl)-2-oxo-5-oxazolidinyl) methyl disodium phosphate (da-7218), have shown very good activity against several gram positive bacteria, including nocardia and mycobacterium. in the present work we evaluated the therapeutic in vivo effects of da-7218 on nocardia ... | 2008 | 18259127 |
| in situ detection and distribution of inflammatory cytokines during the course of infection with nocardia brasiliensis. | actinomycetoma, caused by the intracellular bacterium nocardia brasiliensis, is characterized by an infiltration of several inflammatory cell populations. to explore aspects of the immune response in the pathogenesis of these bacteria we injected 10(6) cfu in footpads of balb/c mice. after 1, 2, 3, 4, 7, 30 and 90 days immunohistochemistry was performed to compare presence and distribution of the inflammatory cytokines tnf-alpha, il-1 beta, il-6, ifn-gamma, il-4, il-10, and tgf-beta. analysis of ... | 2008 | 18283642 |
| in vivo therapeutic effect of gatifloxacin on balb/c mice infected with nocardia brasiliensis. | in the present work, we evaluated the effect of gatifloxacin on the evolution of experimental murine infection with nocardia brasiliensis using linezolid as a control. gatifloxacin was injected subcutaneously at 100 mg/kg body weight every 8 h for 4 weeks. this compound was equally as efficient as linezolid in reducing the production of lesions. | 2008 | 18285484 |
| utility of helical computed tomography to evaluate the invasion of actinomycetoma; a report of 21 cases. | actinomycetoma is a chronic infection caused by several aerobic actinomycetes; it is a relatively frequent condition in tropical countries like mexico. it is important to be aware of the extension and depth of the disease (bone and visceral) to make the prognosis and select treatment. | 2008 | 18294320 |
| immune response to nocardia brasiliensis extracellular antigens in patients with mycetoma. | the ability of culture-filtrate proteins to induce a cellular immune response in infected mice and humans was investigated. a crude extract culture filtrate of nocardia brasiliensis (cfa) and five semi-purified cfa fractions (p1, p2, p3, p4, p5) were used to stimulate balb/c mice spleen-cell cultures. the animals were divided into three groups: the first group was infected with 1 x 10(7) cfu of n. brasiliensis in the footpad, the second group was immunized with heat-killed bacteria, and the thir ... | 2008 | 18302006 |
| lymphocutaneous nocardiosis and cutaneous pheohyphomycosis in a liver transplant recipient. | infections are the leading cause of morbidity and mortality in transplanted patients. the increasing number of immunocompromised patients has not only augmented infections by specific pathogens, but also by opportunistic microbial agents. | 2008 | 18477146 |
| cloning of the gene cluster responsible for the biosynthesis of brasilicardin a, a unique diterpenoid. | brasilicardin a (bca), produced by nocardia brasiliensis ifm 0406 (currently referred to as n. terpenica), has a unique structure consisting of a diterpene skeleton with l-rhamnose, n-acetylglucosamine, amino acid, and 3-hydroxybenzoate moieties, and exhibits potent biological activities. to understand the biosynthetic machinery of this unique compound, we have cloned the corresponding gene cluster. firstly, we cloned a gene by pcr that encodes geranylgeranyl diphosphate synthase (ggpps), which ... | 2008 | 18503195 |
| lymphocutaneous type of nocardiosis caused by nocardia brasiliensis: a case report and review of primary cutaneous nocardiosis caused by n. brasiliensis reported in japan. | nocardiosis is a mixed suppurative and granulomatous inflammatory disease caused by infection with nocardia organisms, a group of aerobic actinomycetes. we recently encountered a 25-year-old woman with posttraumatic nocardiosis of the lower extremities. the clinical symptoms noted during her first visit included erythematous swelling of the right knee accompanied by white maceration of the center of the knee and erosions, shallow ulcers and satellite pustules. in addition, multiple erythematous ... | 2008 | 18578712 |
| spontaneous arthritis in mrl/lpr mice is aggravated by staphylococcus aureus and ameliorated by nippostrongylus brasiliensis infections. | rheumatoid arthritis is an autoimmune disease that affects human beings worldwide. infections have been associated to autoimmune diseases because their ability to induce a dominant cytokine response. joint inflammation has been related to th1 response because they induce high expression of proinflammatory cytokines tnf-alpha, il-1, ifn-gamma. mrl/lpr mice spontaneously develop an autoimmune disease affecting joints, kidneys, etc. we compared incidence and severity of arthritis, antibody response ... | 2009 | 18608175 |
| nodular lymphangitis: a distinctive clinical entity with finite etiologies. | nodular lymphangitis, characterized by inflammatory nodules along the lymphatics draining a primary skin infection, most commonly follows superficial inoculation with sporothrix schenckii, nocardia brasiliensis, mycobacterium marinum, leishmania (viannia) panamensis/guyanensis, and francisella tularensis. epidemiologic context, clinical presentation, and presumed incubation period help to predict the specific etiologic microorganism. sporotrichosis, often occurring in gardeners, remains the most ... | 2008 | 18687205 |
| mycetoma of the chest wall due to nocardia brasiliensis. | 2008 | 18779894 | |
| therapeutic effect of a novel oxazolidinone, da-7867, in balb/c mice infected with nocardia brasiliensis. | mycetoma is a chronic infectious disease of tropical and subtropical countries. it is produced by true fungi and actinobacteria. in méxico, nocardia brasiliensis is the main causative agent of mycetoma, producing about 86% of the cases; the gold standard for the therapy of mycetoma by n. brasiliensis is the use of sulfonamides which give a 70% cure rate. the addition of amikacin to this regime increases to 95% the cure rate; however, the patients have to be monitored for creatinine clearance and ... | 2008 | 18820738 |
| efficacy of ciprofloxacin and moxifloxacin against nocardia brasiliensis in vitro and in an experimental model of actinomycetoma in balb/c mice. | the efficacy of ciprofloxacin and moxifloxacin against nocardia brasiliensis was evaluated by applying 25 mg of each drug/kg subcutaneously every 8 h in balb/c mice infected with n. brasiliensis. a statistically significant difference was observed only with moxifloxacin. a moxifloxacin-trimethoprim-sulfamethoxazole combination was as active as when each compound was used alone. | 2009 | 18852277 |
| actinomycetoma by nocardia brasiliensis in a girl with down syndrome. | we describe the case of a 14-year-old girl with down syndrome and a large cutaneous plaque localized to the right neck and shoulder that had enlarged over five years after a minor traumatic injury. the plaque was characterized by numerous inflammatory nodules and fistulae that secreted purulent discharge. nocardia grains were identified and nocardia brasiliensis was identified by culture. histopathology examination showed a chronic inflammatory infiltrate with granuloma development. the treatmen ... | 2008 | 19061569 |
| nocardia brasiliensis modulates ifn-gamma, il-10, and il-12 cytokine production by macrophages from balb/c mice. | interferon-gamma (ifn-gamma) is a critical cytokine involved in control of different infections. actinomycetoma is a chronic infectious disease mainly caused by the bacterium nocardia brasiliensis, which destroys subcutaneous tissue, including bone. currently, the mechanism of pathogenesis in n. brasiliensis infection is not known. here, we demonstrate that n. brasiliensis induced an ifn-gamma response in serum after 24 h of infection, while, in infected tissue, positive cells to ifn-gamma appea ... | 2009 | 19231999 |
| actinomycetoma in arm disseminated to lung with grains of nocardia brasiliensis with peripheral filaments. | actinomycetomas represent 97.8% of mycetomas in mexico, where 86.6% are produced by nocardia brasiliensis. we report a case of actinomycetoma in the arm by nocardia brasiliensis disseminated to lung. uncommon grains were observed which present outside peripheral filaments and also numerous filaments loosing the grains. these characteristics of the grains are due probably because for the long treatment with antibiotics of the patient. in situ antibiotic action against the microcolonies is discuss ... | 2009 | 19238584 |
| [primary lymphocutaneus nocardiosis by nocardia brasiliensis in an immunocompetent patient]. | 2009 | 19268986 | |
| comparative in vitro activities of nemonoxacin, doripenem, tigecycline and 16 other antimicrobials against nocardia brasiliensis, nocardia asteroides and unusual nocardia species. | the aim of this study was to assess the in vitro activities of nemonoxacin (a novel non-fluorinated quinolone), doripenem, tigecycline and 16 other antimicrobial agents against the nocardia species. | 2009 | 19398458 |
| [nocardia brasiliensis cellulitis in an injection drug user]. | 2009 | 19409674 | |
| [acquired hemophilia complicated with multiple muscle abscess by nocardia]. | an 82-year-old man was referred to our hospital because of bilateral leg swelling and ecchymosis. a hemostatic study showed prolonged aptt, <1% factor viii coagulant activity, and a high titer (30.4 bethesda units/ml) of factor viii inhibitor. the diagnosis of acquired hemophilia a (aha) was made, and treatment with prednisolone (psl) was started. within one month of treatment, the hemorrhagic symptom disappeared, aptt levels returned to normal, and his factor viii inhibitor was eradicated; howe ... | 2009 | 19571510 |
| nocardia iowensis sp. nov., an organism rich in biocatalytically important enzymes and nitric oxide synthase. | nocardia strain nrrl 5646, isolated from a garden soil sample in osceola, iowa, usa, was initially of interest as an antibiotic producer. it contained biocatalytically important enzymes and represented the first described nitric oxide synthase enzyme system in bacteria. the present polyphasic taxonomic study was undertaken to differentiate strain nrrl 5646(t) from related species of the genus nocardia. chemotaxonomic analyses included determinations of the fatty acid methyl ester profile (c(16 : ... | 2009 | 19622667 |
| igm but not igg monoclonal anti-nocardia brasiliensis antibodies confer protection against experimental actinomycetoma in balb/c mice. | nocardia brasiliensis is a facultative intracellular microorganism that produces a human chronic infection known as actinomycetoma. human and mouse anti-n. brasiliensis antibody response identify p24, p26 and p61 immunodominant antigens. in this work, we generated immunoglobulin m (igm) and igg monoclonal antibodies (mabs) specific to immunodominant p61 antigen. the monoclonal igm (nbm1) and igg2a (nbg1) antibodies were assessed for their in vitro bactericidal activity, in vivo protective effect ... | 2009 | 19624737 |
| assignment of reference 5'-end 16s rdna sequences and species-specific sequence polymorphisms improves species identification of nocardia. | 16s rdna sequence analysis is the most accurate method for definitive species identification of nocardiae. however, conflicting results can be found due to sequence errors in gene databases. this study tested the feasibility of species identification of nocardia by partial (5'-end 606-bp) 16s rdna sequencing, based on sequence comparison with "reference" sequences of well-annotated strains. this new approach was evaluated using 96 american type culture collection (n=6), and clinical (n=90) nocar ... | 2009 | 19639036 |
| activity of novel oxazolidinones against nocardia brasiliensis growing within thp-1 macrophages. | nocardia are organisms that can escape the effects of both immune response and antimicrobial agents, due to their potential capacity to grow intracellularly. in previous studies, we found that experimental oxazolidinones, da-7157 and da-7218, are active both in vitro and in vivo. | 2009 | 19710075 |
| speciation and susceptibility of nocardia isolated from ocular infections. | twenty nocardia spp. isolated from ocular infections were identified by 16s rrna gene sequencing and susceptibility was determined using the e-test (ab biodisk, sweden). species distribution among the 20 isolates was as follows: nocardia levis (n = 7), nocardia farcinica (n = 3), nocardia abscessus (n = 2), nocardia brasiliensis (n = 2), nocardia amamiensis (n = 2), nocardia puris (n = 1), nocardia beijingensis (n = 1), nocardia otitidiscaviarum (n = 1) and nocardia thailandica (n = 1). all isol ... | 2010 | 19832708 |
| clinical and microbiological characteristics of nocardiosis including those caused by emerging nocardia species in taiwan, 1998-2008. | the genus of nocardia is rapidly expanding and the species distribution varies with different geographical locations. we retrospectively reviewed the laboratory records of the bacteriology laboratory at national taiwan university hospital from january 1998 to june 2008 to identify patients with nocardiosis. during the study period, 164 isolates of nocardia spp. were identified from 134 patients but only 113 patients had nocardia infection. nocardia brasiliensis (n = 54) was the most common patho ... | 2010 | 19860823 |
| identification of pathogenic nocardia species by reverse line blot hybridization targeting the 16s rrna and 16s-23s rrna gene spacer regions. | although 16s rrna gene sequence analysis is employed most often for the definitive identification of nocardia species, alternate molecular methods and polymorphisms in other gene targets have also enabled species determinations. we evaluated a combined nocardia pcr-based reverse line blot (rlb) hybridization assay based on 16s and 16s-23s rrna gene spacer region polymorphisms to identify 12 american type culture collection and 123 clinical nocardia isolates representing 14 species; results were ... | 2010 | 19955277 |
| [pulmonary nocardiosis in immunocompromised host: report of 2 cases and review of the literature]. | to investigate the clinical, imaging and pathogenic features of pulmonary nocardiosis and the drug resistance of nocardia. | 2009 | 19958678 |
| in vitro activity of ach-702, a new isothiazoloquinolone, against nocardia brasiliensis compared with econazole and the carbapenems imipenem and meropenem alone or in combination with clavulanic acid. | the in vitro activities of ach-702 and other antimicrobials against 30 nocardia brasiliensis isolates were tested. the mic(50) (mic for 50% of the strains tested) and mic(90) values of ach-702 were 0.125 and 0.5 microg/ml. the same values for econazole were 2 and 4 microg/ml. the mic(50) and mic(90) values of imipenem and meropenem were 64 and >64 microg/ml and 2 and 8 microg/ml, respectively; the addition of clavulanic acid to the carbapenems had no effect. | 2010 | 20308390 |
| lymphocutaneous nocardiosis: a case report and review of the literature. | nocardiosis remains a fairly uncommon disease in the united states. cutaneous nocardiosis is one of many infections that can spread in a sporotrichoid pattern and therefore can be difficult to diagnose without a high index of suspicion. it is mainly caused by nocardia asteroides and nocardia brasiliensis, with n brasiliensis isolated in most cases of lymphocutaneous nocardiosis. we present a case of lymphocutaneous nocardiosis in a 65-year-old immunosuppressed man and review the literature. | 2010 | 20349680 |
| [primary nocardiosis by nocardia brasiliensis in spain]. | 2010 | 20447738 | |
| mycetoma caused by nocardia caviae in the first brazilian patient. | mycetoma is a chronic subcutaneous mycosis caused by exogenous fungi or actinomycetes. this infection has a progressive course and shows a typical clinical characteristic of tumefaction, draining sinuses, and grains. infection initiation is related to local trauma and can spread to muscle, underlying bone, and adjacent organs. nocardia brasiliensis is the most frequent actinomycete isolated, while n. caviae is a rare agent. | 2010 | 20465613 |
| evaluation of the combined therapy of da-7218, a new oxazolidinone, and trimethoprim/ sulfamethoxazole in the treatment of experimental actinomycetoma by nocardia brasiliensis. | objectives: currently, for actinomycetoma, combined antimicrobial therapy is preferred to the use of a single compound. this is in order to provide a broader-spectrum coverage due to a combinatory or synergistic effect between the drugs, and to decrease the possibility of emergence of natural resistant strains. a new oxazolidinone pro-drug, da-7218 [(r)-3-(4-(2-(2-methyltetrazol-5-yl)-pyridin-5-yl)-3-fluorophenyl)-2-oxo-5-oxazolidinyl) methyl-disodium-phosphate] (recently re-named tr-701), has s ... | 2010 | 20497102 |
| [actinomycetoma by nocardia brasiliensis]. | 2010 | 20537969 | |
| construction of a nocardia brasiliensis fluorescent plasmid to study actinomycetoma pathogenicity. | nocardia brasiliensis, is a bacteria that lives as saprophyte in soil and causes a disease called actinomycetoma in both human and animals. nocardia brasiliensis is an intracellular, facultative bacterium that replicates and survives within host macrophages. the mechanisms involved in the evasion of the microbicidal actions of macrophages remain unclear. the filamentous growth of n. brasiliensis is resistant to unicellular preparations, leading to inaccurate quantification of bacterial numbers b ... | 2010 | 20875450 |
| [clinical analysis of 26 cases of nocardiosis]. | to describe the clinical characteristics of nocardiosis. | 2010 | 21092630 |
| in situ tlr2 and tlr4 expression in a murine model of mycetoma caused by nocardia brasiliensis. | actinomycetoma caused by nocardia brasiliensis is a common disease in tropical regions. this ailment is characterized by a localized chronic inflammation that mainly affects the lower limbs. toll-like receptors (tlrs) recognize pathogen-associated molecular patterns, inducing the production of proinflammatory mediators. the role of tlrs in the immune response against n. brasiliensis is unknown. the aim of this work was to locate and quantify in a murine model the expression of tlr2 and tlr4 in t ... | 2011 | 21205004 |
| nocardia brasiliensis primary pulmonary nocardiosis with subcutaneous involvement in an immunocompetent patient. | this is a report of an unusual case of nocardia brasiliensis causing primary pulmonary nocardiosis with disseminated subcutaneous lesions in an immunocompetent patient. this case highlights the importance of considering nocardiosis as a differential diagnosis in patients with pulmonary and cutaneous lesions and the need for vigorous management for complete cure. | 2011 | 21304201 |
| primary lymphocutaneous nocardiosis due to nocardia brasiliensis which was successfully treated with only oral potassium iodide. | 2010 | 21352313 | |
| characterization of fe(iii) sequestration by an analog of the cytotoxic siderophore brasilibactin a: implications for the iron transport mechanism in mycobacteria. | mycobacteria such as m. tuberculosis represent a significant health concern throughout much of the developing world. in mycobacteria and other pathogenic bacteria, an important virulence factor is the ability of the bacterium to obtain iron from its host. one means of obtaining iron is through the use of siderophores. brasilibactin a is a membrane bound siderophore produced by nocardia brasiliensis with structural similarity to the mycobactin class of siderophore in mycobacteria. a characterizat ... | 2011 | 21442123 |
| genome characterization of the polyvalent lytic bacteriophage gte2 with the potential for biocontrol of gordonia, rhodococcus and nocardia stabilized foams in activated sludge plants. | hydrophobic actinobacteria are commonly associated with the stabilization of foams in activated sludge systems. one possible attractive approach to control these foam stabilizing organisms is to use specific bacteriophages. we describe the genome characterization of a novel polyvalent dna phage, gte2, isolated from activated sludge. this phage is lytic for gordonia terrae, rhodococcus globerulus, rhodococcus erythropolis, rhodococcus erythropolis, nocardia otitididiscaviarum, and nocardia brasil ... | 2011 | 21498753 |
| [microbiological and clinical features of nine cases with nocardial infections]. | following recent advance in medical technology, the increase of immunocompromised patients results in an increase of opportunistic infections such as nocardiosis. however, little is known about relationships between clinical features of nocardial infections and each nocardia species, especially newly identified ones. therefore, we identified clinical isolates of nocardia species by genetic methods and analyzed clinical features of nocardiosis. nine clinical isolates were obtained in kyushu unive ... | 2011 | 21560401 |
| actinomycetoma of the scalp after a car accident. | actinomycetoma is the most frequent type of mycetoma in mexico. localization on the scalp is very rare. because of this topography and potential spread to the brain, the present case became a diagnostic and therapeutic challenge. | 2011 | 21699522 |
| decrease of virulence for balb/c mice produced by continuous subculturing of nocardia brasiliensis. | subculturing has been extensively used to attenuate human pathogens. in this work we studied the effect of continuous subculturing of nocardia brasiliensis hujeg-1 on virulence in a murine model. | 2011 | 22029431 |
| [Young girl with abscesses in the face]. | Skin and soft tissue infections are most often caused by Staphylococcus aureus or various species of streptococcus. This case report summarizes the clinical features, diagnosis, treatment and clinical outcome of a facial infection presenting as multiple abscesses in a young and otherwise healthy girl. Nocardia brasiliensis was recovered from abscess aspiration, and treatment failure was eventually recognized for the recommended empirical antibiotic treatment, broad-spectrum antibiotics an ... | 2011 | 22085952 |
| primary pulmonary infection caused by 20% acid fast nocardia brasiliensis. | 2011 | 22120819 |