Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| prevalence of gastroesophageal reflux disease in patients with nontuberculous mycobacterial lung disease. | knowledge of the relationship between respiratory disorders and gastroesophageal reflux disease (gerd) is increasing. however, the association between gerd and pulmonary disease caused by nontuberculous mycobacteria (ntm) has not been studied in detail. we investigated the prevalence of gerd in patients with the nodular bronchiectatic form of ntm lung disease. | 2007 | 17400680 |
| [atypical mycobacteriosis of the skin caused by mycobacterium abscessus in an immunocompetent woman]. | mycobacterium abscessus is the most pathogenic of the fast-growing mycobacteria, and it is resistant to most of the antimicrobial and tuberculostatic drugs available. this non-tuberculous mycobacterium is significant in medicine because it can contaminate post-traumatic wounds and be a causative agent in chronic skin and soft tissue infection after surgical procedures.a 60-year-old immunocompetent woman was suffering from chronic ulcers and abscesses on the heels and malleoli of both feet. histo ... | 2007 | 17429583 |
| a paradigm for the molecular identification of mycobacterium species in a routine diagnostic laboratory. | the aim of this study was to improve the identification of mycobacterium species in the context of a uk teaching hospital. real-time pcr assays were established to enable the rapid differentiation between mycobacterium tuberculosis (mtb) complex and mycobacterium species other than tuberculosis (mott), followed by 16s rrna gene sequencing for the speciation of mott. real-time pcr assays gave comparable results to those from the reference laboratory. the implementation of these pcr assays using a ... | 2007 | 17446280 |
| atypical mycobacterial infection in patients with cystic fibrosis: update on clinical microbiology methods. | while patients with cystic fibrosis (cf) have had dramatic improvement in their survival rates, this has been accompanied by the emergence of more virulent pathogens such as pseudomonas aeruginosa and burkholderia cepacia complex organisms. in addition, there has been emergence of organisms of increasing clinical significance such as the nontuberculous mycobacterial (ntm). although tb infection in patients with cf is extremely uncommon, there is growing concern with regard to atypical mycobacter ... | 2007 | 17451510 |
| genomics of glycopeptidolipid biosynthesis in mycobacterium abscessus and m. chelonae. | the outermost layer of the bacterial surface is of crucial importance because it is in constant interaction with the host. glycopeptidolipids (gpls) are major surface glycolipids present on various mycobacterial species. in the fast-grower model organism mycobacterium smegmatis, gpl biosynthesis involves approximately 30 genes all mapping to a single region of 65 kb. | 2007 | 17490474 |
| infective crystalline keratopathy secondary to non-tuberculous mycobacterium (mycobacterium abscessus) in a non-traumatized eye. | 2007 | 17525765 | |
| fish gambler's tenosynovitis caused by mycobacterium marinum: environmental investigation of a fishing pond in southern taiwan. | we describe a patient with mycobacterium marinum tenosynovitis associated with a fish spine injury acquired at a gambling fishing pond in southern taiwan and identify the source of the infection. m. marinum was isolated from fishing ponds and underground water and wastewater at the site. the isolates shared the same pulsed-field gel electrophoresis pattern as the patient. m. marinum was not detected in 54 samples obtained from 27 fish. mycobacterium gordonae was isolated from 24 samples collecte ... | 2007 | 17572037 |
| application of polymerase chain reaction-based restriction fragment length polymorphism in typing ocular rapid-growing nontuberculous mycobacterial isolates from three patients with postoperative endophthalmitis. | we describe postoperative endophthalmitis caused by rapid-growing nontuberculous mycobacteria (rgntm) in 3 patients after small-incision cataract surgery with intraocular lens (iol) implantation performed elsewhere and referred to us for management. subsequent identification and confirmation was carried out with biochemical tests and polymerase chain reaction-based restriction fragment length polymorphism (pcr-rflp). | 2007 | 17592326 |
| in vitro efficacy of imipenem in combination with six antimicrobial agents against mycobacterium abscessus. | antimicrobial therapy of mycobacterium abscessus infection is difficult because there are relatively few effective treatment regimens and single-agent therapy frequently fails clinically. in light of the lack of data on the susceptibility profile of m. abscessus strains recovered from infections in japan, the in vitro activity of imipenem in combination with clarithromycin, levofloxacin, moxifloxacin, minocycline, amikacin or tobramycin was investigated by the checkerboard method and compared wi ... | 2007 | 17616451 |
| alpha-1-antitrypsin (aat) anomalies are associated with lung disease due to rapidly growing mycobacteria and aat inhibits mycobacterium abscessus infection of macrophages. | rapidly growing mycobacteria (rgm) are ubiquitous in the environment but cause lung disease in only a fraction of exposed individuals. this variable susceptibility to disease implies vulnerability to rgm infection due to weakness in host defense. since most persons who contract rgm lung disease have no known host defense defect, it is likely that uncharacterized host deficiencies exist that predispose to rgm infection. alpha-1-antitrypsin (aat) is a host factor that may protect individuals from ... | 2007 | 17654345 |
| prosthetic joint infection due to rapidly growing mycobacteria: report of 8 cases and review of the literature. | prosthetic joint infection (pji) due to rapidly growing mycobacteria (rgm) is only occasionally encountered in clinical practice. therefore, the optimal clinical management for this condition is unknown. | 2007 | 17712751 |
| bilateral deep anterior lamellar keratoplasty for the management of bilateral post-lasik mycobacterial keratitis. | a 25-year-old vietnamese man who had bilateral simultaneous laser in situ keratomileusis (lasik) for moderate myopia developed bilateral mycobacterium abscessus keratitis that was treated with intensive medical therapy, flap removal, superficial keratectomy, and, following disease progression, therapeutic deep anterior lamellar keratoplasty (dalk). to our knowledge, this is the first reported case of bilateral post-lasik mycobacterial keratitis successfully treated with dalk. | 2007 | 17720084 |
| rapidly growing mycobacteria: clinical and microbiologic studies of 115 cases. | we analyzed clinical and microbiologic features of 115 cases involving rapidly growing mycobacteria (rgm) isolated at the university of texas m.d. anderson cancer center, houston (2000-2005) and identified by 16s ribosomal rna gene sequencing analysis. at least 15 rgm species were included: mycobacterium abscessus (43 strains [37.4%]), mycobacterium fortuitum complex (33 strains [28.7%]), and mycobacterium mucogenicum (28 strains [24.3%]) most common, accounting for 90.4%. most m abscessus (32/4 ... | 2007 | 17875513 |
| importance of t cells, gamma interferon, and tumor necrosis factor in immune control of the rapid grower mycobacterium abscessus in c57bl/6 mice. | mycobacterium abscessus is an emerging rapidly growing mycobacterium that causes tuberculous-like lesions in humans. we studied the immune control of this organism in c57bl/6 mice challenged intravenously with 10(7) cfu. bacteria were eliminated from both the spleen and the liver within 90 days, and liver histology showed organized granulomatous lesions. a t- and b-cell requirement was investigated by challenging rag2-/-, cd3epsilon-/-, and mumt-/- mice. rag2-/- and cd3epsilon-/- mice were signi ... | 2007 | 17875636 |
| successful recovery after disseminated infection due to mycobacterium abscessus in a lung transplant patient: subcutaneous nodule as first manifestation--a case report. | mycobacterium abscessus infection following lung transplantation (lt) has been described in a few cases. it is characterized by a variable initial location and subsequent course in this special risk group of patients, particularly those with cystic fibrosis (cf). herein we have presented the case of a patient subjected to lt due to cf, who 1 year after transplantation developed a subcutaneous nodule produced by m abscessus, with subsequent hematogenous spread as well as bronchial and bone marrow ... | 2007 | 17889205 |
| mycobacterium other than tuberculosis (mott) infection: an emerging disease in infliximab-treated patients. | infliximab has revolutionized treatment of rheumatologic diseases and inflammatory bowel disease. however, it increases the risk of tuberculosis. less is known about the development of mycobacterium other than tuberculosis (mott) infection. we review the literature on non-tuberculous mycobacterial infections in infliximab-treated patients and report the first case of disseminated mycobacterium avium complex in an infliximab-treated patient complicated by immune reconstitution inflammatory syndro ... | 2007 | 17920687 |
| decreased cytokine production in patients with nontuberculous mycobacterial lung disease. | nontuberculous mycobacteria (ntm) are intracellular pathogens that elicit a specific t-cell response characterized by the production of proinflammatory cytokines, including interferon (ifn)-gamma, tumor necrosis factor (tnf)-alpha, and interleukin (il)-12. however, little information exists regarding the levels of specific cytokines in patients with ntm lung disease. therefore, we compared cytokine production in peripheral blood mononuclear cells (pbmcs) from patients with ntm lung disease with ... | 2007 | 17926095 |
| microbial substitution of mycobacterium avium-intracellulare to mycobacterium abscessus during clinical course. | mycobacterium avium-intracellulare (mai) is, among acid-fast bacilli, the most common cause of nontuberculous pulmonary diseases, and mai infections are often treated according to the guidelines of the american thoracic society. however, despite the use of multiple drugs, patients sometimes do not recover with the initial round of treatment. other kinds of nontuberculous mycobacteria are sometimes found in patients' respiratory samples, even during such treatment for mai pulmonary disease. we ex ... | 2007 | 17982725 |
| a case report of mycobacterium abscessus peritonitis in a peritoneal dialysis patient. | peritonitis due to nontuberculous mycobacterium in peritoneal dialysis (pd) patients is rare. however, when it occurs, pd catheter removal is required in most cases because of resistance to antibiotic therapy. we report a case of mycobacterium abscessus peritonitis subsequent to tunnel infection after pd catheter-replacement surgery. the patient underwent this surgery as her tunnel infection had not resolved following the usual 3 month course of antibiotic therapy. after surgery, tunnel infectio ... | 2007 | 18028172 |
| localised pyogranulomatous dermatitis due to mycobacterium abscessus in a cat: a case report. | a case of pyogranulomatous dermatitis, caused by mycobacterium abscessus, an unusual opportunistic mycobacterium spp., is described in a cat. histopathological examination of the affected skin confirmed the diagnosis and ziehl-neelsen staining revealed acid-fast rods. a rapidly growing mycobacterium was found after culture on a löwenstein-jensen medium. real-time polymerase chain reaction for the 16s rdna (434bp) sequence and the sequence of the rpob gene (359bp) revealed 99% and 100% matches, r ... | 2009 | 18083608 |
| mycobacterium abscessus infection in a case of recurrent orbital implant exposure. | exposure is one of the most frequent complications of porous orbital implants, while infection is rarely observed. atypical mycobacteria are ubiquitous germs of mostly variable pathogenicity. a patient with recurrent orbital implant exposure is described, in whom a final diagnosis of mycobacterium abscessus infection was made on culture of the orbital implant remnant at its removal. in orbital implant exposure, infection with unexpected organisms should be considered and in these cases only the ... | 2007 | 18097981 |
| the changing pattern of nontuberculous mycobacterial disease. | nontuberculous mycobacteria are human opportunistic pathogens whose source of infection is the environment. these include both slow-growing (eg, mycobacterium kansasii and mycobacterium avium) and rapid-growing (eg, mycobacterium abscessus and mycobacterium fortuitum) species. transmission is through ingestion or inhalation of water, particulate matter or aerosols, or through trauma. the historic presentation of pulmonary disease in older individuals with predisposing lung conditions and in chil ... | 2003 | 18159470 |
| pseudo-outbreak of mycobacterium abscessus infection caused by laboratory contamination . | to investigate the cause(s) of an increased incidence of clinical cultures growing mycobacterium abscessus at a hospital in florida. | 2008 | 18171188 |
| molecular characterization of mycobacterium massiliense and mycobacterium bolletii in isolates collected from outbreaks of infections after laparoscopic surgeries and cosmetic procedures. | an outbreak of infections affecting 311 patients who had undergone different invasive procedures occurred in 2004 and 2005 in the city of belém, in the northern region of brazil. sixty-seven isolates were studied; 58 were from patients who had undergone laparoscopic surgeries, 1 was from a patient with a postinjection abscess, and 8 were from patients who had undergone mesotherapy. all isolates were rapidly growing nonpigmented mycobacteria and presented a pattern by pcr-restriction enzyme analy ... | 2008 | 18174307 |
| iris root abscess and necrotizing sclerokeratitis caused by mycobacterium abscessus and presenting as hemorrhagic anterior uveitis. | to report a case of an iris abscess and necrotizing sclerokeratitis caused by mycobacterium abscessus and presenting as hemorrhagic uveitis. | 2008 | 18216592 |
| the organization of two rrna (rrn) operons of the slow-growing pathogen mycobacterium celatum provides key insights into mycobacterial evolution. | the slow-growing mycobacterium celatum is known to have two different 16s rrna gene sequences. this study confirms the presence of two rrn operons and describes their organization. one operon (rrna) was found to be located downstream from mura and the other (rrnb) was found downstream from tyrs. the promoter regions were sequenced, and also the intergenic transcribed spacer (its1 and its2) regions separating the 16s rrna, 23s rrna and 5s rrna gene coding regions. analysis of the rna fraction rev ... | 2008 | 18248431 |
| in vitro antimicrobial susceptibility of mycobacterium abscessus in korea. | mycobacterium abscessus is the second most common etiology of pulmonary disease caused by nontuberculous mycobacteria in korea. although antimicrobial susceptibility tests are important for appropriate patient management in m. abscessus lung disease, the tests have never been investigated in korea. seventy-four isolates of m. abscessus recovered from patient respiratory samples were tested against eight antimicrobial agents following the guidelines set forth by the national committee for clinica ... | 2008 | 18303198 |
| animal model of mycobacterium abscessus lung infection. | chronic lung disease as a result of mycobacterium abscessus is an emerging infection in the united states. we characterized the lung immune responses in mice and guinea pigs infected with m. abscessus. c57bl/6 and leptin-deficient ob/ob mice challenged with a low-dose aerosol (lda) of m. abscessus did not develop an infection. however, when challenged with a high-dose aerosol (hda), c57bl/6 and ob/ob mice developed an established infection and a pulmonary immune response consisting of an early i ... | 2008 | 18310351 |
| in vitro and ex vivo activity of new derivatives of acetohydroxyacid synthase inhibitors against mycobacterium tuberculosis and non-tuberculous mycobacteria. | sulfometuron methyl (sm) is an inhibitor of acetohydroxyacid synthase (ahas), the first common enzyme in the branched-chain amino acid biosynthetic pathway, and shows activity against mycobacterium tuberculosis both in vitro and in vivo. to develop ahas inhibitor derivatives with more potent activity, 100 sulfonylurea analogues were screened for antimycobacterial activity against m. tuberculosis and non-tuberculous mycobacteria (ntm), and then evaluated for intracellular activity using mouse mac ... | 2008 | 18337064 |
| mycobacterium abscessus activates the macrophage innate immune response via a physical and functional interaction between tlr2 and dectin-1. | mycobacterium abscessus (mab) is an emerging and rapidly growing non-tuberculous mycobacterium (ntm). compared with m. tuberculosis, which is responsible for tuberculosis, much less is known about ntm-induced innate immune mechanisms. here we investigated the involvement of pattern-recognition receptors and associated signalling in mab-mediated innate immune responses. mab activated the extracellular signal-regulated kinase (erk)1/2 and p38 mitogen-activated protein kinases (mapks), and induced ... | 2008 | 18373632 |
| differential antibiotic susceptibility of mycobacterium abscessus variants in biofilms and macrophages compared to that of planktonic bacteria. | mycobacterium abscessus causes refractory pulmonary infections requiring surgery for cure. it exists as a smooth biofilm-forming phenotype which is noninvasive and a rough, non-biofilm-forming phenotype which can invade macrophages and cause persistent pulmonary infection in mice. we have postulated that the dissociation of the smooth phenotype to the rough phenotype may lead to invasive lung disease following initial colonization of the airways. amikacin, cefoxitin, and clarithromycin are stand ... | 2008 | 18378709 |
| mycobacterium abscessus and m. avium trigger toll-like receptor 2 and distinct cytokine response in human cells. | mycobacterium avium (mav) and m. abscessus (mab) are ubiquitous environmental organisms increasingly recognized to cause chronic lung disease in patients with apparently normal immune function. little is yet known about their human pathophysiology. our objective was to examine cytokine and chemokine responses (protein and gene expression) and signaling pathways triggered by reference and clinical isolates of mab and mav in human peripheral blood mononuclear cells, monocytes, and murine bone marr ... | 2008 | 18441280 |
| outbreak of mycobacterium abscessus wound infections among "lipotourists" from the united states who underwent abdominoplasty in the dominican republic. | some us residents travel abroad to undergo cosmetic surgery for fat removal, a practice referred to as "lipotourism." mycobacterium abscessus can cause postsurgical wound infection. | 2008 | 18444853 |
| antimicrobial resistance of rapidly growing mycobacteria in western taiwan: smart program 2002. | to understand the resistance patterns of rapidly growing mycobacteria (rgm) in taiwan, antimicrobial resistance of clinical isolates was determined as part of the smart (surveillance from multicenter antimicrobial resistance in taiwan) program. | 2008 | 18445541 |
| mycobacterium abscessus infection complicating hand rejuvenation with structural fat grafting. | summary: we report a case of mycobacterium abscessus infection of the hands in a 55 year old lady following hand rejuvenation with structural fat grafting. a review of the literature on m. abscessus infection to discuss common presentations, diagnosis and treatment is presented. awareness and high suspicion of such as atypical mycobacterial infections complicating hand surgery and other plastic surgery procedures is imperative to successful management. | 2009 | 18472321 |
| disseminated cutaneous infection with mycobacterium abscessus in a patient with a low cd4+ t cell count. | we report an uncommon case of disseminated cutaneous infection with mycobacterium abscessus. the patient was a 22-year-old female with low level of cd4+ t cells in the peripheral blood cells, who presented with a number of tender red nodules, erythema and erythematous infiltrated plaques on her cheek, neck and extremities. colonies without pigment grew after incubating on löwenstein-jensen (l-j) medium at 37 degrees c and 32 degrees c for 3-5 days. polymerase chain reaction (pcr) amplification o ... | 2008 | 18474467 |
| mycobacterium abscessus infection after breast augmentation: a case of contaminated implants? | infections after breast augmentation are uncommon, occurring in 1-3% of cases. treatment often requires additional surgeries and may yield a sub-optimal cosmetic result. for this reason, post implant infection remains a serious concern among plastic surgeons. a 48-year-old female presented to our clinic with bilateral breast implant infections 3 months after primary augmentation in china. cultures grew mycobacterium abscessus, a previously undescribed infectious aetiology after breast augmentati ... | 2009 | 18485852 |
| interleukin-12 receptor beta1 polymorphisms and nontuberculous mycobacterial lung diseases. | the pathway involving interferon-gamma and interleukin (il)-12 plays an important role in host defense against mycobacterial infections. recent studies have indicated that il-12 receptor beta1 (il-12rbeta1) gene polymorphisms are associated with susceptibility to pulmonary tuberculosis. however, there have been no reports of an association between il-12rbeta1 gene polymorphism and lung disease caused by nontuberculous mycobacteria (ntm). the present study involved 128 patients with the nodular b ... | 2008 | 18493823 |
| spectrum of cns disease caused by rapidly growing mycobacteria. | we present a case of a patient with chronic meningoencephalitis caused by mycobacterium abscessus. we also summarise the clinical features and outcomes of cases of cns infection caused by rapidly growing mycobacteria that have been described in the literature. rapidly growing mycobacteria are notorious for causing skin and soft-tissue infections after trauma or surgery, pulmonary disease in patients with cystic fibrosis, and disseminated disease in immunocompromised patients. cns infection with ... | 2008 | 18501854 |
| late-onset posttraumatic skin and soft-tissue infections caused by rapid-growing mycobacteria in tsunami survivors. | in the tsunami catastrophe in thailand in 2004, several thousand swedish tourists were injured, with contaminated crush trauma of the legs being the main cause of injury among the survivors. | 2008 | 18549312 |
| rapid speciation of 15 clinically relevant mycobacteria with simultaneous detection of resistance to rifampin, isoniazid, and streptomycin in mycobacterium tuberculosis complex. | to design and standardize an in-house reverse line blot hybridization (rlbh) assay for the accurate identification of 15 clinically relevant species of mycobacteria and for the detection of drug resistance to rifampin (rif), isoniazid (inh), and streptomycin (str) in mycobacterium tuberculosis complex (mtb). | 2009 | 18565777 |
| an autopsy case of mycobacterium abscessus pulmonary infection complicated with rheumatoid arthritis. | we present the case of a 70-year-old man diagnosed with mycobacterium abscessus pulmonary infection complicated with rheumatoid arthritis who was treated with corticosteroids. he died despite treatment according to the recommended regimen of imipenem, clarithromycin, and amikacin. autopsy revealed granulomatous lesions throughout the bilateral lungs. we conclude that m. abscessus infection may have a fatal outcome because of the drug resistance of the pathogen. this case suggests that rheumatoid ... | 2008 | 18591855 |
| association between microsatellite polymorphisms in intron ii of the human toll-like receptor 2 gene and nontuberculous mycobacterial lung disease in a korean population. | this study evaluated the association between the guanine-thymine (gt) repeat polymorphism in intron ii of the toll-like receptor 2 (tlr2) gene and lung disease caused by nontuberculous mycobacteria (ntm). polymerase chain reaction and gene scans were used to determine the numbers of gt repeats for 193 patients with the nodular bronchiectatic form of ntm lung disease, including 110 patients with mycobacterium avium-intracellulare (mac) infection, 82 patients with mycobacterium abscessus infection ... | 2008 | 18602432 |
| in vitro activity of flomoxef against rapidly growing mycobacteria. | the aim of this study was to determine the in vitro sensitivity of rapidly growing mycobacteria (rgm) to flomoxef in respiratory secretions collected from 61 consecutive inpatients and outpatients at chang gung memorial hospital-kaohsiung medical center between july and december, 2005. minimal inhibitory concentrations (mic) of flomoxef were determined by the broth dilution method for the 61 clinical isolates of rgms. the mics of flomoxef at which 90% of clinical isolates were inhibited was >128 ... | 2008 | 18606583 |
| mycobacterium abscessus infection secondary to mesotherapy. | 2008 | 18616719 | |
| postoperative mycobacterium abscessus nodular conjunctivitis. | non-tuberculous or 'atypical' mycobacteria are unusual causes of ocular or periocular infection. we report a case of postoperative mycobacterium abscessus infection of the conjunctiva. a 71-year-old gentleman developed nodular conjunctival injection and irritation 6 weeks after cataract surgery. after failure of topical therapy with antibiotics, steroids and lubricants, a biopsy was taken. histological examination revealed non-caseating granulomas within which were clusters of acid-fast bacilli, ... | 2008 | 18700926 |
| proportions of mycobacterium massiliense and mycobacterium bolletii strains among korean mycobacterium chelonae-mycobacterium abscessus group isolates. | korean isolates of the mycobacterium chelonae-mycobacterium abscessus group, which had been isolated from two different hospitals in south korea, were identified by pcr restriction analysis (pra) and comparative sequence analysis of 16s rrna genes, rpob, and hsp65 to evaluate the proportion of four closely related species (m. chelonae, m. abscessus, m. massiliense, and m. bolletii). of the 144 rapidly growing mycobacterial strains tested, 127 strains (88.2%) belonged to the m. chelonae-m. absces ... | 2008 | 18753344 |
| [pulmonary nodules in a patient on long-term steroid treatment]. | we report on a patient who was chronically treated with steroids. she simultaneously developed pulmonary nocardiosis as well as a soft tissue infection and osteomyelitis by mycobacterium abscessus. both infections are rare, but more frequently occur in immunocompromised hosts. the patient was healed after 12 month of adequate antibiotic treatment. | 2008 | 18754339 |
| mycobacterium abscessus, an uncommon cause of chronic otitis media: a case report and literature review. | 2008 | 18794448 | |
| biofilm development by potentially pathogenic non-pigmented rapidly growing mycobacteria. | a study to evaluate the biofilm-development ability in three different media (middlebrook 7h9, sterile tap water and pbs-5% glucose) was performed with 19 collection strains from 15 different species on non-pigmented rapidly growing mycobacteria (nprgm). a microtiter plate assay was developed to evaluate the percentage of covered surface of the microtiter plate wells in different days from day 1 to day 69. | 2008 | 18928544 |
| sporotrichoid nodules caused by mycobacterium abscessus. | 2008 | 19002354 | |
| acute respiratory failure involving an r variant of mycobacterium abscessus. | we report the case of a cystic fibrosis patient colonized with a smooth-morphotype form of mycobacterium abscessus who developed acute respiratory failure with the emergence of an isogenic rough (r) variant while he was recovering from peritonitis-induced shock. this report emphasizes the role of r forms in severe m. abscessus infections. | 2009 | 19020061 |
| mycobacterium abscessus endocarditis: a case report and literature review. | infective endocarditis owing to mycobacterium abscessus infection is rarely reported. most cases of infective endocarditis caused by mycobacterium abscessus are seen in patients after valve replacement. although early surgical intervention is recommended and medical treatment with antibiotics according to the susceptibility to the pathogen, such as amikacin, imipenem, cefoxitin, quinolones and macrolides, are applied, the course of such endocarditis is usually subacute and often has fatal outcom ... | 2008 | 19073380 |
| the antioxidant mimetic, mnte-2-pyp, reduces intracellular growth of mycobacterium abscessus. | mycobacterium abscessus is a rapidly growing environmental mycobacterium that can cause severe skin, soft tissue, and lung infections. m. abscessus grows inside macrophages, and these cells release a vast number of proinflammatory cytokines in response to infections. the metalloporphyrin, mnte-2-pyp, is a broad antioxidant that reduces inflammatory cell signaling. macrophage-like thp-1 cells were infected with m. abscessus in the presence or absence of mnte-2-pyp. mnte-2-pyp significantly decrea ... | 2009 | 19097985 |
| construction of mycobacterium abscessus defined glycopeptidolipid mutants: comparison of genetic tools. | mycobacterium abscessus is a rapidly growing mycobacterial species that can be involved in pulmonary and disseminated infections in immunosuppressed or young cystic fibrosis patients. it is an emerging pathogen and has attracted recent attention due to the numerous cases of infection; furthermore, genomic tools have been developed for this species. nevertheless, the study of this species has until now been limited to spontaneous variants. we report here a comparison of three different mutagenesi ... | 2009 | 19114521 |
| screening for sterilizing activity of antibiotic combinations in an acid model of rapidly growing mycobacteria during the stationary phase of growth. | in view of the problems of correlation between the data provided by classical microbiological studies and clinical response, we designed an in vitro method to screen for the sterilizing activity of various antibiotics, individually or in combinations, against clinical isolates of various rapidly growing mycobacteria in the stationary phase. | 2009 | 19155619 |
| a novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of mycobacterium abscessus but is absent from mycobacterium chelonae. | mycobacterium abscessus infections tend to respond poorly to macrolide-based chemotherapy, even though the organisms appear to be susceptible to clarithromycin. circumstantial evidence suggested that at least some m. abscessus isolates might be inducibly resistant to macrolides. thus, the purpose of this study was to investigate the macrolide phenotype of m. abscessus clinical isolates. inducible resistance to clarithromycin (mic > 32 microg/ml) was found for 7 of 10 clinical isolates of m. absc ... | 2009 | 19171799 |
| lines of evidence for horizontal gene transfer of a phenazine producing operon into multiple bacterial species. | phenazines are secondary metabolites with broad-spectrum antibiotic activity against bacteria, fungi, and eukaryotes. in pseudomonad species, a conserved seven-gene phenazine operon (phzabcdefg) is required for the conversion of chorismic acid to the broad-spectrum antibiotic phenazine-1-carboxylate. previous analyses of genes involved in phenazine production from nonpseudomonad species uncovered a high degree of sequence similarity to pseudomonad homologues. the analyses undertaken in this stud ... | 2009 | 19189039 |
| immunoproteomic identification of secretory and subcellular protein antigens and functional evaluation of the secretome fraction of mycobacterium immunogenum, a newly recognized species of the mycobacterium chelonae-mycobacterium abscessus group. | mycobacterium immunogenum has been associated with occupational pulmonary disease hypersensitivity pneumonitis (hp). the aim of this study was to identify immunogenic proteins (antigens) in this pathogen as a first step toward understanding its virulence factors and role in hp etiology. immunoproteomic profiling of secreted and subcellular protein fractions using a combination of two-dimensional electrophoresis (2-de), immunoblotting, and matrix-assisted laser desorption/ionization-time of fligh ... | 2009 | 19209886 |
| hla antigens and nontuberculous mycobacterial lung disease in korean patients. | human leukocyte antigen (hla) molecules are known to play an important role in host-defense mechanisms. the aim of this study was to evaluate the association between hla alleles and lung disease caused by nontuberculous mycobacteria (ntm) in korean patients. | 2009 | 19219503 |
| mycobacterium abscessus post-injection abscesses from extrinsic contamination of multiple-dose bottles of normal saline in a rural clinic. | we investigated an outbreak of gluteal abscesses following intramuscular (im) injections given at a clinic in rural china to identify the causative agent, source, and method of exposure. | 2009 | 19269204 |
| unresolving furunculosis in a diabetic patient: cutaneous mycobacterium abscessus infection. | 2009 | 19271048 | |
| mycobacterium abscessus from respiratory isolates: activities of drug combinations. | mycobacterium abscessus is the most resistant of rapidly growing pathogenic mycobacteria. we performed a screening of the in vitro sterilizing capacity of various antibiotic combinations against two strains isolated from respiratory samples (in vitro activity of each antibiotic: 51 combinations of two drugs and 47 of three drugs). our findings confirm that clarithromycin is the most useful drug. the combination of this drug with linezolid exhibits good activity. in addition, the fluoroquinolones ... | 2009 | 19280301 |
| successful treatment with pneumonectomy for pulmonary mycobacterium abscessus infection. | we report a case of pulmonary mycobacterium abscessus (m. abscessus) infection with destructive growth in the entire right lung. the patient was 56-year-old woman who had had pulmonary tuberculosis at the age of 40 and had been diagnosed as having pulmonary mycobacterium abscessus infection 4 years prior to admission at our hospital. although various antibiotics were administered, persistent fever, hemoptysis and weight loss developed. after undergoing a right pneumonectomy, her clinical symptom ... | 2009 | 19293547 |
| mycobacterium abscessus in cystic fibrosis lung transplant recipients: report of 2 cases and risk for recurrence. | mycobacterium abscessus is increasingly recognized as an important pathogen in some individuals with advancing lung disease related to cystic fibrosis (cf). because of its resistance to antimicrobial agents and virulence, its presence in the lungs of potential lung transplant recipients can be problematic. we present 2 cases of individuals with cf in whom m. abscessus was present in the preoperative sputum cultures. the organism manifested different degrees of invasiveness in the 2 cases after t ... | 2009 | 19298240 |
| microbiological spectrum of organisms isolated from explanted scleral buckles. | scleral buckle removal is an uncommon procedure performed for various reasons. microbiological information on explanted scleral buckles remains limited. the authors identified 37 cases of scleral buckle removal during an 18-year period. bacterial cultures isolated an organism in 4 of 9 patients (44%) with clinical infection. organisms identified included methicillin-resistant staphylococcus aureus, pseudomonas aeruginosa, mycobacterium abscessus, and coagulase-negative staphylococcus species. ba ... | 2009 | 19320315 |
| arteriovenous graft infection caused by mycobacterium abscessus in a hemodialysis patient. | 2009 | 19356386 | |
| cohort study of molecular identification and typing of mycobacterium abscessus, mycobacterium massiliense, and mycobacterium bolletii. | mycobacterium abscessus is the most common cause of rapidly growing mycobacterial chronic lung disease. recently, two new m. abscessus-related species, m. massiliense and m. bolletii, have been described. health care-associated outbreaks have recently been investigated by the use of molecular identification and typing tools; however, very little is known about the natural epidemiology and pathogenicity of m. massiliense or m. bolletii outside of outbreak situations. the differentiation of these ... | 2009 | 19420162 |
| pulmonary nontuberculous mycobacterial infections: antibiotic treatment and associated costs. | recent studies suggest an increasing prevalence of pulmonary nontuberculous mycobacteria (ntm) disease. in the absence of prevalence and cost data, the public health burden of pulmonary ntm disease is difficult to assess. the goal of this study was to assess costs associated with ntm disease treatment and to identify risk factors associated with increased costs. records from subjects with pulmonary ntm disease enrolled in a natural history protocol were abstracted for presenting symptoms, comorb ... | 2009 | 19467851 |
| identification of non-tuberculous mycobacteria: utility of the genotype mycobacterium cm/as assay compared with hplc and 16s rrna gene sequencing. | non-tuberculous mycobacteria (ntm) causing clinical disease have become increasingly common and more diverse. a new reverse line probe assay, genotype mycobacterium cm/as (hain lifescience), was evaluated for identification of a broad range of ntm. it was compared with phenotypic (hplc) and molecular (dna probes, in-house real-time multiplex species-specific pcr, 16s rrna gene pcr and sequencing) identification techniques, which together provided the reference 'gold standard'. a total of 131 cli ... | 2009 | 19502366 |
| inaccuracy of single-target sequencing for discriminating species of the mycobacterium abscessus group. | we determined nucleotide sequences of rpob, hsp65, and soda in 59 clinical isolates (from 58 patients) of the mycobacterium abscessus group. identification to the species level, based on three target genes, was concordant for 44 isolates (25 m. abscessus, 13 mycobacterium massiliense, and 6 mycobacterium bolletii isolates) and discordant for 15 isolates which had "interspecific composite patterns." sequence analysis of five housekeeping genes also showed composite patterns in 8 of these 15 isola ... | 2009 | 19515839 |
| comparison of clinical and radiographic characteristics between nodular bronchiectatic form of nontuberculous mycobacterial lung disease and diffuse panbronchiolitis. | the nodular bronchiectatic form of nontuberculous mycobacterial (ntm) lung disease and diffuse panbronchiolits (dpb) show similar clinical and radiographic findings. the present study was performed to clarify the clinicoradiographic similarities as well as the differences between ntm lung disease and dpb. the initial clinicoradiographic features of 78 patients with the nodular bronchiectatic form of ntm lung disease (41 patients with mycobacterium avium complex infection and 37 patients with myc ... | 2009 | 19543504 |
| non mycobacterial virulence genes in the genome of the emerging pathogen mycobacterium abscessus. | mycobacterium abscessus is an emerging rapidly growing mycobacterium (rgm) causing a pseudotuberculous lung disease to which patients with cystic fibrosis (cf) are particularly susceptible. we report here its complete genome sequence. the genome of m. abscessus (cip 104536t) consists of a 5,067,172-bp circular chromosome including 4920 predicted coding sequences (cds), an 81-kb full-length prophage and 5 is elements, and a 23-kb mercury resistance plasmid almost identical to pmm23 from mycobacte ... | 2009 | 19543527 |
| nontuberculous mycobacteria isolated during the treatment of pulmonary tuberculosis. | the significance of nontuberculous mycobacteria (ntm) isolated from a patient during therapy for pulmonary tuberculosis (tb) is uncertain. we investigated the frequency and clinical significance of ntm isolated from patients receiving anti-tb treatment. | 2009 | 19576745 |
| femoropopliteal prosthetic bypass graft infection due to mycobacterium abscessus localized by fdg-pet/ct scan. | a patient with postvascular graft placement presented with bacteremia but no localizing symptoms. our standard infected graft workup of computed tomography (ct) scan, ultrasound scan, magnetic resonance imaging (mri) scan, and additional laboratory tests did not localize the infection source. nuclear medicine had three options including white blood cell (wbc) scan, gallium scan, and the fluorine-18-fluorodeoxyglucose positron emission tomography (fdg-pet)/ct scan. fdg-pet/ct imaging alone demons ... | 2009 | 19595547 |
| mycobacterium abscessus glycopeptidolipids mask underlying cell wall phosphatidyl-myo-inositol mannosides blocking induction of human macrophage tnf-alpha by preventing interaction with tlr2. | mycobacterium abscessus causes disease in patients with structural abnormalities of the lung, and it is an emerging pathogen in patients with cystic fibrosis. colonization of the airways by nontuberculous mycobacteria is a harbinger of invasive lung disease. colonization is facilitated by biofilm formation, with m. abscessus glycopeptidolipids playing an important role. m. abscessus can transition between a noninvasive, biofilm-forming, smooth colony phenotype that expresses glycopeptidolipid, a ... | 2009 | 19596998 |
| antibiotic treatment of mycobacterium abscessus lung disease: a retrospective analysis of 65 patients. | the optimal therapeutic regimen and duration of treatment for mycobacterium abscessus lung disease is not well established. | 2009 | 19661243 |
| detection of lfra and tap efflux pump genes among clinical isolates of non-pigmented rapidly growing mycobacteria. | this study was performed to detect lfra and tap efflux pumps among clinical isolates of non-pigmented rapidly growing mycobacteria (nprgm). gene detection was performed using polymerase chain reaction (pcr) with specific primers designed for each gene. susceptibility of the strains to doxycycline, tigecycline and ciprofloxacin was analysed using the broth microdilution reference technique. in total, 166 clinical isolates were included in the study. the lfra gene was detected in four strains (2.4 ... | 2009 | 19665358 |
| mycobacterium abscessus infection in solid organ transplant recipients: report of three cases and review of the literature. | mycobacterium abscessus is an ubiquitous organism found in the environment. this rapidly growing mycobacterium infrequently causes disease in humans; however, in immunocompromised hosts, disease can range from localized cutaneous lesions to disseminated infection. the organism is resistant to most antimycobacterial drugs and therapy can be limited by drug interactions. the exact incidence of m. abscessus infection among solid organ transplant (sot) recipients is unknown; data are only available ... | 2009 | 19671119 |
| an outbreak of skin and soft tissue infection caused by mycobacterium abscessus following acupuncture. | although outbreaks of mycobacterium abscessus infection have been reported, none of these reports has identified the potential sources of infection and modes of transmission. in april 2008, we identified and investigated an outbreak of m. abscessus skin and soft tissue infections following acupuncture among the patients who visited an oriental medical clinic. active surveillance of patients who had visited the clinic was conducted to define the extent of the outbreak. environmental cultures and ... | 2010 | 19694761 |
| mycobacterial bacteraemia in patients infected and not infected with human immunodeficiency virus, taiwan. | the clinical characteristics and outcomes of 71 patients with mycobacterial bacteraemia, infected with human immunodeficiency virus (hiv) (n = 47) and not infected with hiv (n = 24) are described. mycobacterium avium complex (mac) (54.9%) constituted the most frequently isolated mycobacterium, followed by mycobacterium tuberculosis (mtb) (38.0%), mycobacterium kansasii (4.2%), and mycobacterium abscessus (2.8%). the beijing family genotype was the most common type in mtb, and mycobacterium intra ... | 2010 | 19709128 |
| clinical relevance of mycobacterium chelonae-abscessus group isolation in 95 patients. | to determine the clinical relevance of mycobacterium chelonae-abscessus group isolation from clinical samples. | 2009 | 19732795 |
| a case of mycobacterium abscessus skin infection caused by multiple acupunctures. | 2010 | 19758379 | |
| [radiographic findings of pulmonary nontuberculous mycobacteriosis other than mycobacterium avium complex]. | almost all nontuberculous mycobacteria (ntm) cause opportunistic infection. therefore, the radiographic findings of ntm have a tendency of nonspecific patterns modifying the predisposing conditions or diseases and we could not extract species specific radiographic characterizations in that situations. in this review, the ntm cases without predisposing conditions or diseases are submitted essentially. mycobacterium kansasii cases show more or less the same patterns with tb cases. mycobacterium fo ... | 2009 | 19764463 |
| extensive cutaneous mycobacterium abscessus infection due to contaminated insulin delivery system. | 2009 | 19776153 | |
| molecular identification of rapidly growing mycobacteria isolates from pulmonary specimens of patients in the state of pará, amazon region, brazil. | we isolated 44 strains of rapidly growing mycobacteria (rgm) from 19 patients with pulmonary infections assisted at the instituto evandro chagas (pará, brazil) from 2004 to 2007. identification at the species level was performed by pcr restriction fragment length polymorphism analysis (pra) of a 441 bp hsp65 fragment and partial 16s rrna, hsp65, and rpob gene sequencing. genotyping by pra yielded 3 digestion patterns: one identical to mycobacterium abscessus type i (group i); another to m. absce ... | 2009 | 19796904 |
| high virulent clinical isolates of mycobacterium abscessus from patients with the upper lobe fibrocavitary form of pulmonary disease. | pulmonary disease caused by nontuberculous mycobacteria (ntm), including mycobacterium abscessus, can be classified into two distinct types of clinical disease; the upper lobe fibrocavitary (uc) form and nodular bronchiectatic (nb) form. however, the relationship between mycobacterial strain virulence and disease type in the pulmonary m. abscessus diseases has not been reported. to determine the differential virulence between strains causing two forms of disease, we obtained clinical isolates fr ... | 2009 | 19800962 |
| intrathoracic nontuberculous mycobacterial infections in otherwise healthy children. | background: nontuberculous mycobacterial (ntm) infection is typically associated with lymphadenitis in immune competent children, and disseminated disease in children with immune deficiencies. isolated pulmonary ntm disease is seen in cystic fibrosis, and is increasingly recognized in immunocompetent elderly women, where it is associated with an increased incidence of cystic fibrosis transmembrane regulator (cftr) mutations. thoracic ntm infection has been reported rarely in otherwise healthy ch ... | 2009 | 19824053 |
| non-tuberculous mycobacteria in children with cystic fibrosis: isolation, prevalence, and predictors. | screening for non-tuberculous mycobacteria (ntm) is recommended for adults with cystic fibrosis (cf). the relevance of this organism in north american pediatric cf patients is unclear as there is limited ntm prevalence data for children. we aimed to determine the prevalence of ntm in children with cf from a single expectorated sputum and identify clinical predictors of ntm isolation. additionally, we compared two different sputum decontamination methods before mycobacterial culture. | 2009 | 19830845 |
| multicenter study of prevalence of nontuberculous mycobacteria in patients with cystic fibrosis in france. | we performed a multicenter prevalence study of nontuberculous mycobacteria (ntm) involving 1,582 patients (mean age, 18.9 years; male/female ratio, 1.06) with cystic fibrosis in france. the overall ntm prevalence (percentage of patients with at least one positive culture) was 6.6% (104/1,582 patients), with prevalences ranging from 3.7% (in the east of france) to 9.6% (in the greater paris area). mycobacterium abscessus complex (mabsc; 50 patients) and mycobacterium avium complex (mac; 23 patien ... | 2009 | 19846643 |
| comparative analysis of immune responses to mycobacterium abscessus infection and its antigens in two murine models. | mycobacterium abscessus has been identified as an emerging pulmonary pathogen in humans. because little is known regarding immune responses elicited by m. abscessus or its antigens, immunological responses were studied in two murine models subjected to intravenous (high-dose or systemic infection) or pulmonary (low-dose or local infection) inoculation with m. abscessus atcc 19977. an overall comparison between the two models showed similar patterns of bacterial survival and host immune responses ... | 2009 | 19851737 |
| familial clustering of pulmonary nontuberculous mycobacterial disease. | nontuberculous mycobacteria (ntm) are environmental organisms associated with pulmonary disease without person-to-person transmission. although genetic causes of disseminated ntm infection are well characterized, genetic causes for most human susceptibility to pulmonary ntm infection have not been determined. | 2010 | 19858235 |
| onco-reconstructive techniques in the treatment of tuberculosis of the breast. | a 54-year-old woman presented with mastitis, which did not respond to conventional oral antibiotic therapy. tissue biopsy led to the diagnosis of tuberculosis of the breast. the underlying causative organism was found to be mycobacterium abscessus, recognised as being a particularly pathogenic strain of tuberculosis.(1) initial treatment involved surgical debridement and antibiotic therapy. following this, onco-reconstructive techniques were used to remove scarred tissue from the affected side a ... | 2010 | 19892613 |
| current treatment of atypical mycobacteriosis. | atypical mycobacteria are a heterogeneous group of organisms that are of increasing importance because of the growing number of infections they cause. this rising rate of infection is due mainly to the increase in the number of susceptible (and especially immunosuppressed) patients. | 2009 | 19929702 |
| venous catheter-associated bacteremia caused by rapidly growing mycobacteria at a medical center in central taiwan. | infections due to rapidly growing mycobacteria (rgm) are increasing worldwide, especially in immunocompromised hosts, but data on the clinical features of patients with rgm bacteremia are limited in taiwan. this study was performed to determine the features associated with rgm. | 2009 | 19949759 |
| fatal mycobacterium abscessus endocarditis misidentified as corynebacterium spp. | the microbiological similarities of rapidly growing mycobacteria and corynebacteria impose potential for misidentification in the laboratory. this report describes a fatal case of infectious endocarditis caused by mycobacterium abscessus, initially identified and treated as corynebacterium spp. acid-fast staining should be performed routinely when multiple blood cultures grow corynebacterium spp. | 2010 | 19958237 |
| carbapenem susceptibility patterns for clinical isolates of mycobacterium abscessus determined by the etest method. | mycobacterium abscessus is resistant to multiple antibiotics, creating treatment challenges. carbapenems are tested to increase therapeutic alternatives. we performed in vitro susceptibility testing by etest of four carbapenems for m. abscessus isolates. imipenem demonstrated the most in vitro activity, and testing of other carbapenems provided no additional value. | 2010 | 20018813 |
| [mycobacterium abscessus infection in insulin injection sites in a diabetic patient]. | insulin injection site abscesses have been attributed to pyogenic streptococci and staphylococcus aureus. in this report, the authors describe a patient in whom mycobacterium abscessus was isolated from one of multiple insulin injection sites. the article reviews six additional cases of rapidly growing mycobacteria identified as the causative agent of skin infections at insulin injection sites. in most cases, precise identification of the source of infection was not successful. possibly, inadequ ... | 2009 | 20027976 |
| otomastoiditis caused by mycobacterium abscessus, the netherlands. | 2010 | 20031077 | |
| sequential bilateral lung resection in a patient with mycobacterium abscessus lung disease refractory to medical treatment. | mycobacterium abscessus (m. abscessus) is the second most common nontuberculous mycobacteria (ntm) in south korea. nevertheless, the diagnosis and treatment of m. abscessus lung disease can be problematic. surgical resection has been tried for patients with localized m. abscessus lung disease refractory to medical treatment. here, we report on a 25-year-old woman with m. abscessus lung disease who had been diagnosed and treated three times for pulmonary tuberculosis. she was initially diagnosed ... | 2010 | 20046529 |