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biochemical studies of pigments from a pathogenic fungus microsporum cookei. iii. comparison of the effects of xanthomegnin and o-methylxanthomegnin on the oxidative phosphorylation of rat liver mitochondria.the effects of xanthomegnin and o-methylxanthomegnin on the oxidative phosphorylation of rat liver mitochondria were compared. the n-octanol/water partition coefficient of xanthomegnin was markedly enhanced by o-methylation, but o-methylation of xanthomegnin reduced the uncoupling effect on the respiratory system of mitochondria. analogous results were obtained in the uncoupling action of 5-hydroxy-1, 4-naphthoquinone (juglone) and 5-methoxy-1, 4-naphthoquinone (o-methyljuglone) on the oxidative ...1976939756
[mycological investigation of anthropozoonotic microsporisis (microsporum canis bodin, 1902). (first occurrence in slovakia) (author's transl)]. 1976944105
conidiogenesis in pathogenic hyphomycetes. i. sporothrix, exophiala, geotrichum and microsporum.conidium formation in 5 species of pathogenic hyphomycetous fungi, sporothrix schenckii, exophiala salmonis, e. sp., geotrichum candidum and microsporum canis were examined using light and scanning electron microscopy. the fungi, grown in pure culture on potato dextrose agar under defined conditions, demonstrated 4 kinds of conidiogenesis. the taxonomic value of the developmental characters in the classification of the fungi imperfecti is discussed.1976944466
antimicrobial agents. xxvii. antifungal activity of substituted phenols and their addition salts with 2-aminotridecane towards dermatophytes. 1976947834
hansch analysis in a series of substances with antifungal activity. 1976954947
[the immunological activity under a therapy with griseofulvin and pyrogenic agents in microsporum infections]. 1976955194
[ultrastructure of microsporum canis in studies by scanning and penetrating light electron microscopy]. 1976955203
microsporum nanum infection in south australia.two cases of human ringworm caused by the dermatophyte microsporum nanum are reported from south australia. m. nanum is the commonest cause of ringworm in pigs and is known to cause porcine infections in australia. this report shows the value of mycological investigations in determining the possible source of such infections.1976958065
sulphitolysis in keratinolysi. biochemical proof.the presence of s-sulphocysteine in filtrates of the dermatophyte keratinomyces ajelloi growing on human hair in a culture medium buffered by ph 7-4 by phosphates was demonstrated by means of ion exchange chromatography techniques. s-sulphocysteine being destroyed during acidic hydrolysis was identified after enzymic hyrolysis of dialyzed and lyophilized filtrates. this result indicates that sulphitolysis occurs during kerationlysis performed by k. ajelloi. as thiosulphuric esters were shown pre ...1976959943
[m. canis carrier state in man]. 1976961057
[comparative data on griseofulvin treatment of microsporosis caused by microsporum canis with regard to certain characteristics of its pathogenesis]. 1976961060
studies on the biological effects of deuteriated organic compounds. i. antifungal activity of perdeuteriated fatty acids on dermatophytes in vitro.the antifugal activity of some perdeuteriated fatty acids, with normal chain 11 to 18 carbon atoms, was investigated on common dermatophytes epidermophyton floccosum, microsporum canis, trichophyton mentagrophytes and t. rubrum under in vitro conditions. these studies were performed by dilution technique and with respiratory measurements, perdeuteriation of some fatty acids increases their inhibitory effect on the dermatophyte growth. perdeuteriated n-hendecanoic acid proved to be the most activ ...1976967223
studies on the biological effects of deuteriated organic compounds. iii. antifungal activity of perdeuteriated fatty acids on dermatophytes in vivo experimental microsporie in guinea pigs.investigations on the antimycotic properties of perdeuteriated fatty acids were carried out on microsporum cains infections in vivo. the study was performed on experimental microsporie in guinea pigs using four different methods, all based on the ability of m. canis to cause alopecia. perdeuteriated n-hendecanoic acid showed in vivo a statistically significant enhanced antimycotic effect compared to its unlabelled analogue. this is in accordance with our previous observations in vitro conditions ...1976967225
kerion-like tinea capitis and barbae caused by microsporum gypseum in israel.four cases of hair invasion by microsporum gypseum are reported. in three the scalp was involved and in one, the beard. all presented a kerion type of invasion. in 3 cases hair penetration was of the ectothrix type, while in one case the kerion of the scalp resembled the type of invasion seen in t. schonleini infection. none of the invaded hairs showed fluorescence in wood's light. the soil was the source of infection in 3 patients, the fungus having been isolated from soil samples collected in ...1976967226
keratin decomposition by dermatophytes. ii. presence of s-sulfocysteine and cysteic acid in soluble decomposition products.the dermatophyte microsporum gypseum was grown on human hair in a mineral medium. filtrates of cultures of various age were chromatographed on sephadex gels and further characterized by chemical analysis and thin-layer chromatography. the products of keratin decomposition were separated into two fractions. the first fraction formed 10 to 20% of the bulk and contained proteins low in sulfur content. the second, very wide fraction contained oligopeptides and polypeptides with molecular weights fro ...1976969572
[scanning electron microscopic study of the human hair, affected by the dermatophyte microsporum gypseum (bodin) guiart and griogorakis in vitro]. 1976980003
tolciclate against dermatophytes.0-(1,2,3,4-tetrahydro-1,4-methanonaphthalen-6-yl)-m-n-dimethylthiocarbanilate (toliciclate; kc 9147) is a new topical antimycotic having an in vitro activity on dermatophytes between 0.1 and 0.01 mug/ml. it is fungicidal after some day's contact. it has the advantage over dyes used in the past for topical treatment of dermatomycoses in that it is colourless and is soluble in well tolerated excipients. it is more liposoluble than tolnaftate. in the guineapig skin infections with trichophyton aste ...1976989349
[antimicrobialy active agents. xxviii. fungicidal activity of benzylphenols]. 1976991289
synthesis and preliminary antimicrobial screening of two thiosulfonates.tetramethylene bis(methanethiosulfonate), the s-ester analog of busulfan, was prepared by reacting 1,4-dibromobutane with potassium methanethiosulfonate. 2,4-dichlorophenyl methanethiosulfonate was prepared by reacting sodium methanesulfinate with 2,4-dichlorobenzenesulfenyl chloride. neither compound showed antifungal activity against microsporum audouini or trichophyton mentagrophytes. although tetramethylene bis(methanethiosulfonate) was more active against staphylococcus aureus than was 2,4- ...1976994004
microsporum racemosum: first isolation in the united states.what is believed to be the first isolation in the united states of the dermatophyte microsporum racemosum (2) was obtained from a 79 year old white male. the patient had numerous excoriations on the forehead, scalp, and nape of the neck. (fig. 1) a culture of scrapings from the forehead grew out a flat, granular, cream-colored colony with a red cherry-colored pigment on the reverse. (fig. 2). the growth was exceedingly rapid, reaching a thallus of 40 mm. in diameter within 15 days. on microscopi ...1976995173
[diagnosis of glabrous skin rubromycosis in children]. 1976997870
[ultrastructure of m. canis before and after exposure to griseofulvin (scanning and transmission electron microscopy)]. 1976997878
[biometric analysis of the neutral variability of mycelial growth of dermatophyte macrocolonies on glucose-peptone-agar during the exponential growth phase. ii. strain heterogeneity]. 19761004520
[microsporum and microsporum infections. i. microsporum isolated in a nonparasitic state from the zoological park of paris and its neighborhood]. 19761004523
[microsporum and microsporum infections. ii. thermotolerance; morphological variations and linear mycelial growth observed as function of temperature]. 19761004528
[griseofulvin resistance in microsporosis patients]. 19761014843
studies on the prevalence of ringworm among horses in racing and breeding stables.a survey of 568 horses in training and 2,535 horses on breeding farms has shown 32 percent of the horses in training to be clinically affected while only 1.1 percent of breeding horses were affected with pathogenic dermatophytes. the majority of lesions on racing horses were located on the girth areas. trichophyton equinum var. autotrophicum, m. canis and m. equinum were found to be restricted to racing horses only. m. gypseum occurred in racing, riding and breeding horses.19761016167
photolocalized tinea facialis.the case of a 34-year-old white woman with tinea facialis that persisted for nine months prior to diagnosis is presented. the confluent plaquelike erythematous eruption of the face with eyelid lichenification that flared outdoors was thought to represent polymorphic light eruption and was refractory to antibiotics, corticosteroids (topical and systemic), and antimalarials. a koh preparation was positive when the dermatosis spilled onto the mandibular region, and restaining of the initial skin bi ...19761017266
[certain urgent problems of treatment of microsporosis of the scalp (according to the questionnaire materials of the donets regional scientific society of dermatovenereologists)]. 19761023648
genus microsporum dermatophytes in eastern bohemia.the authors presented a taxonomic survey of dermatophytes of the genus microsporum. from the 19 species described so far, they isolated ten species in the region of eastern bohemia. only the species microsporum cookel and m. gypsem are considered to be endemic species. the remaining are regarded as imported dermatophytes which are not able to maintain their existence permanently in the conditions of the mentioned region. data on the findings of the individual species were completed by the author ...19761033224
first european report of swine infection by microsporum nanum.the first european case of swine infection by microsporum nanum is reported. the infected pig came from a farm in the emilia-romagna region of italy. european records of human and lower animal infections by this fungus and soil isolation records are discussed.19761033462
genus microsporum dermatophytes in eastern bohemia.the authors presented a taxonomic survey of dermatophytes of the genus microsporum. from the 19 species described so far, they isolated ten species in the region of eastern bohemia. only the species microsporum cookei and m. gypsem are considered to be endemic species. the remaining are regarded as imported dermatophytes which are not able to maintain their existence permanently in the conditions of the mentioned region. data on the findings of the individual species were completed by the author ...19761034655
microsporum gypseum infection in a dromedary camel. 19751041647
[antimycotic antibiotics (author's transl)].a number of antibiotics having an antimycotic action are reviewed. the physicochemical and pharmacotoxicological properties, antifungal range, mechanisms of action, dosage and preparations of griseofulvin, amphotericin-b, natamycin, nystatin and pecilocin are discussed.19761085044
new azasteroidal antifungal antibiotics from geotrichum flavo-brunneum. iii. biological activity.the a25822 antibiotic complex consists of seven biologically active factors. a comparative study of these factors determined that factor b possessed the greatest antifungal activity. the minimal inhibitory concentration of a25822b against isolates of candida albicans was less than 0.3 similar to 5.0 mug/ml, trichophyton mentagrophytes was inhibited at less than 0.0312 mug/ml. other pathogenic fungi such as cryptococcus neoformans, histoplasma capsulatum, blastomyces dermatitidis, sporotrichum sc ...19751089623
isolation of dermatophytes, candida species and systemic fungi from dermatologic specimens in montréal, 1963 to 1973.of 10 057 specimens of scrapings from skin, nails and scalp examined for dermatophytes, yeasts, pityriasis versicolor and systemic mycoses between 1963 and 1973, 30.4 percent were positive for fungi. skin produced the highest proportion (68.6 percent) of positive scrapings, scalp the lowest (4.2 percent). trichophyton rubrum was the predominant species (23.6 percent); of lesser prevalence were microsporum canis (9.3 percent), t. mentagrophytes (8.4 percent) and epidermophyton floccosum (4.8 perc ...19751091342
isolation of keratinophilic fungi from soil in pavia, italy.the examination of keratinophilic fungi in 125 soil samples collected in pavia, italy revealed the following organism: microsporum gypseum 23, m. vanbreuseghemii 4, arthroderma uncinatum 4, ctenomyces serratus 5, chrysosporium tropicum 5, unidentified gymnoascacean 1. arthroderma uncinatum, m. gypseum, m. vanbreuseghemii were isolated from a city park and cultivated soils; c. tropicum, ct. serratus and an unidentified gymnoascacean were found only in soils from natural woods. the distribution of ...19751091998
antidermatophytic activity of 2-thiotetrahydro-1,3,5-thiadiazines and isothiocyanates.benzyl, furfuryl, tetrahydronaphthyl, alpha-picolyl, and alpha-homopicolyl derivatives of 2-thiotetrahydro-1,3,5-thiadiazines were studied and found to be more active than beta-picolyl, and pyridyl analogs on dermatophytes, including the more resistant microsporum canis.19751094101
topical treatment of dermatophytoses and candidoses.in a double-blind trial clotrimazole cream was compared with tolnaftate cream in the treatment of dermatophytoses and with nystatin cream in the treatment of candidoses. clotrimazole was shown to be effective against both dermatophytoses and candidoses and was as effective and acceptable as tolnaftate and nystatin creams in each condition.19751096122
use of immunofluorescence staining in kerion.we describe two cases of kerion caused by trichophyton rebrum and microsporum gypseum. in the histological sections, a pas stain revealed a small number of hypha-like rods and spore-like round bodies in the dermis of patient 1. except for some clusters of pas-positive materials, no definite fungal elements were observed in the dermis of patient 1, whereas a considerable number of hyphae were demonstrated within a hair shaft. immunofluorescence staining, using fluorescein-labeled t mentagrophytes ...19751096827
clotrimazole: a review of its antifungal activity and therapeutic efficacy.clotrimazole 2, a synthetic imidazole derivative, is primarily used locally in the treatment of vaginal and skin infections due to yeasts and dermatophytes. in vitro, it is most active against candida spp., trichophyton spp., microsporum spp. and malazzesia fuffur (pityrosporon orbiculare). in addition, it has some in vitro activity against certain gram-positive bacteria, and at very high concentrations has activity against trichomonas spp. in the treatment of vaginal candidiasis, clotrimazole v ...19751097234
rapamycin (ay-22,989), a new antifungal antibiotic. i. taxonomy of the producing streptomycete and isolation of the active principle.a streptomycete was isolated from an easter island soil sample and found to inhibit candida albicans, microsporum gypseum and trichophyton granulosum. the antibiotic-producing microorganism was characterized and identified as streptomyces hygroscopicus. the antifungal principle was extracted with organic solvent from the mycelium, isolated in crystalline form and named rapamycin. rapamycin is mainly active against candida albicans; minimum inhibitory concentration against ten strains ranged from ...19751102508
letter: tinea capitis--a warning. 19751102883
recovery of nannizzia grubyia from a stray italian cat (felis catus). 19751117886
factors influencing to formation of tinea capitis profundus "kerion celsi". 19751117889
dermatophytes: conidium-ontogeny and classification.the ontogeny of the conidia of representative dermatophyte species has been examined by time-lapse microphotography. the results are summarized in five main conclusions. (i) the genera microsporum, trichophyton and epidermophyton have holoblastic conidium-ontogeny; (ii) the investigated species exhibit polymeristematic development; (iii) delivery of the conidia occurs by means of a special detaching mechanism: consisting in autolysis of a detaching-cell or cells; (iv) the macroconidia have a pri ...19751121930
ultrastructure of ascosporogenesis in nannizzia gypsea.ascosporogenesis in nannizzia gypsea was studied by electron microscopy. development of ascospores began with the formation of an ascus vesicle composed of two paired unit membranes. myelin figures consisting of coiled or concentric membranes were regularly connected with the growing ascus vesicle. both the ascus vesicle and the myelin figures possessed an electron-dense line between paired membranes, and both were stained by the periodic acid-silver methenamine technique. invagination of the as ...19751126919
carbohydrate composition of the isolated cell walls of dermatophytes.in an attempt to evaluate taxonomic character of sugar composition of dermatophytes, the purified cell walls from 13 species are analyzed on neutral sugar composition by gas liquid chromatography. the results were principally compatible with those obtained by conventional morphological examination. neutral sugar components of dermatophytes cell walls were mannose and glucose in the ratio of 1:2.7 for epidermophyton and 1:1.4 for microsporum. there were two types in trichophyton, in which the rat ...19751128648
isolation of chrysophanic acid-9-anthrone, the major antifungal principle of cassia tora.an antifungal principle of defatted seed power of cassia tora linn. was isolated by extraction of an aqueous paste of the powder with benzene, followed by column chromatography over activated silica gel c using chloroform as the developing solvent. besides chrysophanic acid and other hydroxyanthraquinone derivatives, the major antifungal compound was identified as chrysophanic acid-9-anthrone, the structure of which was assigned on the basis of its chemical properties and uv, ir, nmr and mass sp ...19751143018
saprophytic occurrence of trichophyton mentagrophytes and microsporum gypseum in the coats of healthy laboratory animals. (preliminary report).a group of 199 healthy laboratory animals, comprising 63 guinea pigs; 58 white mice. 47 rats and 31 rabbits, was sampled for the presence of pathogenic dermatophytes. t. mentagrophytes, var. granulare, was isolated in 10% (5-guinea pigs, 6 mice, 6 rats and 2 rabbits) and m. gypseum was found in 7 animals (3 guinea pigs, 3 mice and one rat). no ringworm lesions were observed in the respective animals. this is the first report on such findings in israel.19751143311
nosema eurytremae canning 1972 in heart tissue of the land snail bradybaena similaris. 19751145237
the effect of sodium chloride on the growth and morphology of dermatophytes and some other keratolytic fungi.a study of the influence of various concentrations of nac1 on 21 species of dermatophytes and other keratolytic fungi was made. based on the sensitivity of the species to various concentrations of nac1, it was possible to divide them into five groups. microsporum ferrugineum and trichophyton concentricum and t. tonsurans were the most sensitive to nac1 and were inhibited by 5%. the greatest number of species were inhibited by 12% nac1. the fungi most tolerant to nac1 were m. cookei and m. nanum, ...19751148934
miconazole: a review of its antifungal activity and therapeutic efficacy.miconazole2, a synthetic imidazole derivative, is a new topical antifungal agent for use in the local treatment of vaginal, and skin and nail infections due to yeasts and dermatophytes. it is particularly active against candida spp., trichophyton spp., epidermophyton spp., microsporum spp. and pityrosporon orbiculare (malassezia furfur), but also possesses some activity against gram-positive bacteria. in vaginal candidiasis, miconazole vaginal cream has produced higher cure rates than convention ...19751149649
letter: tinea capitis--a warning. 19751152784
[dermatophytosis by microsporum persicolor. 1st brazilian case]. 19751153911
[griseofulvin treatment of microsporosis caused by microsporum canis]. 19751154895
the areal extent of dermatophyte infection.after stripping with vinyl tape, dermatophytes may be cultured throughout the depth of the stratum corneum. in the present study skin strippings were used to investigate the horizontal spread of the dermatophyte infection. in five cases of tinea cruris and in twenty-two cases of tinea corporis, fungi could be cultured not only from the visible lesion, but in the majority of cases also from the normal-looking skin up to 6 cm from the margin of the lesion. no relationship could be found between th ...19751156556
microbial models of mammalian metabolism. o-dealkylation of 10,11-dimethoxyaporphine.microbial transformations of 10,11-dimethoxyaporphine were studied to determine the potential of microorganisms to produce monomethoxyaporphines. ten microorganisms were identified as being capable of yielding apocodeine and/or isoapocodeine as the major metabolite in 24 and 20% yield, respectively. cunninghamella blakesleeana (atcc 9245) converted 10,11-dimethoxyaporphine quantitatively into isapocodeine. o-dealkylation of this aporphine system is a facile microbial transformation, and the 10-m ...19751159695
microsporum canis infection in calves.microsporum canis infection, seldom reported in calves, is described. the organism was isolated from skin scrapings collected from ringworm lesions mainly on the heads of 2 naturally infected calves. the organism was studied in vitro, and experimentally on guinea-pigs.19751162536
[ultrastructure of m. canis in culture and in affected hair]. 19751163107
[treatment of microsporosis with griseofulvin on an intermittent schedule]. 19751163118
a study of the kinetics of microsporogenesis in campelia zanonia (l.) h.b.k.during maturation, microspores pass through a series of morphologically distinguishable stages or compartments. a study has been made of the systematic fluctuations in the frequency of microspores in these compartments, when plants are grown under rigidly controlled conditions. a new approach to the construction of cumulative flux rate curves is described; these give the number of cells passing the compartment boundaries per unit time. the curves obtained indicate that simple models, which assum ...19751170019
aflatoxin-like compounds produced by dermatophytes.using the method of thin-layer chromatography there were investigated the chloroform extracts of 30 dermatophyte mycelia. it was found the presence of aflatoxin-like compounds in six mycelium extracts only, which chromatograms showed the equal rf and the colour of the strains to the strains to the standard aflatoxin extract of bruished peanuts grain rossetti. those six mycelia were: epidermophyton floccosum, nannizzia fulva, n. persicolor, arthroderma gloriae, trichophyton concentricum and t. ga ...19751170494
the isolation of keratinophilic fungi from soils in israel. a preliminary report.one hundred and fourteen soil samples collected from various areas of israel were screened for the presence of keratinophilic fungi. five species were isolated from the 59 positive samples, viz: c. keratinophilum--22 strains, c. evolceanui--18, c. serratus eidam--10, m. gypseum--t. terrestre--4. most of the geophilic organisms were recovered from garden soil, road-side and sandy-soil specimens. the importance of these findings is briefly discussed.19751171370
the ecology of keratinophilic fungi at different depths of soil.the influence of depth and humus content of soil, on the presence of keratinophilic fungi in 4 layers (1-10 cm, 11-25 cm, 26-40 cm, 41-55 cm) of carbonate meadow, chernozem carbonate meadow and carbonate alluvial soils was studied. different keratinophilic fungi were found not only in individual soils but also in different layers of the same soil. the greatest number and quantity occurred in soil with highest humus content. these fungi were present in greatest amount in the superficial layers (1 ...19751172299
bilogical and toxicological properties of econazole, a broad-spectrum antimycotic.the spectrum of activity of 1-(2,4-dichloro-beta-[(p-chlorobenzoyl)oxy]phenethyl)imidazole-nitrate (econazole, r 14827) was tested in vitro on various pathogenic fungi and bacteria, and also in vivo in guinea-pigs and rats experimentally infected with dermatophytes and c. albicans. the in vitro activity spectrum is very broad: the dermatophytes, the yeasts, the dimorphic fungi, the aspergilli, the mycetoma causing agents and the gram-positive bacteria being most sensitive. guinea-pigs infected w ...19751173036
formation of sulphate, sulphite and s-sulphocysteine by the fungus microsporum gypseum during growth on cystine.the dermatophyte microsporum gypseum was cultivated in media containing 0.5% cystine in suspension, and 0.05% peptone or 1% glucose and 0.05% peptone. during growth on cystine the excess sulphur was oxidized and excreted into the medium not only in the form of sulphate but also in the form of sulphite. sulphite was produced especially during first phases of growth, where its quantity was higher than that of sulphate and its maximum concentration exceeded 1 mg/ml. s-sulphocysteine, detected chrom ...19751176037
[keratinophilic fungi in the soil and in soil components of nurseries]. 19751183672
[tinea capitis caused by microsporum ferrugineum. case report]. 19751192473
observations of microsporium canis with cryoscanning and scanning electron microscopy.the observations of microsporum canis with cryoscanning and scanning electron microscopy without fixation and dehydration were reported. in the former an almost native state was observed through showing some fuzzy outlines due to frost; in the latter it was shown that marked shrinkage and distortion had occured. there were many granules on the surface of the macroconidia though their function is uncertain.19751207721
[causative agents of dermatomycosis in horses]. 19751209923
[microsporidia of the simulium larvae: systematic, cytochemical, pathological and ecological data].at present, 10 microsporidian species belonging to the genera nosema, pleistophora, thelohania, stempellia, octosporea, weiseria and caudospora are known as parasites in simuliids larvae. acid mucosubstances fixing alcian blue and proteinic granules rich in -sh groups appear during sporogony in various species of thelohania, pleistophora, stempellia. the microsporidan contracts intimate relations with larval host-cells of the type host-parasite complex and lengthens larval state as well for the ...19751211771
the perfect state of microsporum amazonicum. 19751214833
contribution to the study on fatty acids of epidermophyton floccosum.the total lipid content of a dermatophyte, epidermophyton floccosum, grown under controlled environmental conditions, varies with growth stage and represents 7.0 to 19.8% of the dry weight. the main lipid classes, determined by quantitative thin-layer chromatography, were: triglycerides, free fatty acids, sterols and phospholipids. the fatty acid composition was established with the aid of combined gas chromatography-mass spectrometry. the major components, linoleic, palmitic and stearic acids r ...19751217274
[microsporum equinum as a cause of dermatophytosis in the horse]. 19751217277
[immunological studies on experimental dermatomycosis in the guinea-pig (author's transl)]. 19751218851
[species composition of dermatophytoses in magnitogorsk from 1958 to 1973]. 19751220376
in vitro degradation of human hair by hendersonula toruloidea.the in vitro ability of 5 hendersonula toruloidea and 1 control microsporum gypseum strain to degrade human hair has been studied by analysis of culture medium and microscopy. h. toruloidea was able to utilize human hair as a source of nutrients but the extent varied according to the isolate and in all cases degradation was less marked than with m. gypseum.19751224288
[zoonoses in veterinary practice. 3. chlamydial, rickettsial and fungal infections]. 19751231047
[chemotherapeutic effects of nitro compounds. 1. nitroanilines].more than 200 nitro compounds, most of them nitroaniline derivatives substituted with one or more radicals having a basic reaction, were prepared and investigated as to their therapeutic activity against bacteria, fungi, protozoa, helminths, viruses and tumors. several mono-nitrobenzenes with a radical having a basic reaction showed weak in-vitro activity against gram-positive bacteria and against crocker's sarcoma 180; they also showed systemic activity against nematodes (aspiculuris tetraptera ...19751242309
preparation and in vitro antifungal activities of some quinolizidine derived hemiaminals and beta-tert-amino sulfides.new alpha-thiohemiaminals, 7alpha-phenylthio-7-epideoxynupharidin-6-ol, the diasteriomeric 7beta-phenylthiodeoxy-nupharidin-6-ol, and 3-methyl-3-methylthio-4-hydroxyquinolizidine, were prepared and reduced to the corresponding beta-tert-amino sulfides. the configuration at c-7 of the beta-tert-amino sulfides was determined by observing the direction of the solvent-induced shift of the c-7 methyl proton resonance. the configuration at c-7 of the new alpha-thiohemiaminals was established by correl ...19761249801
the nuclear dna-dependent ribonucleic acid polymerases of the dermatophytic fungus microsporum gypseum.the dna-dependent rna polymerases of the dermatophytic fungus microsporum gypseum were partially characterized. nuclear extracts prepared from vegetative mycelia were fractionated by deae-sephadex chromatography into three enzyme species which resembled in most of their characteristics those of other eukaryotic organisms.19761260524
light resistance in geophilic dermatophytes.the effect of repeated illumination by ultraviolet or visible light on slide cultures of trichophyton ajelloi and microporum cookei was studied. under uv light, germination was inhibited, spores were damaged and destroyed, growth was suppressed and the hyphae were killed. inhibition was dependent on exposure time and wavelength. lethal doses for the far uv range were as high as 1 300-1 700 mw sec/cm2 for t. ajelloi and 2 300 mw sec/cm2 for m. cookei. the same effect was caused by the complete uv ...19761265576
scalp ringworm among black children in south africa and the occurrence of trichophyton yaoundei.the prevalence of tinea capitis among 153 children who were selected by overt signs of scalp infestation from among 658 black schoolchildren, was studied in two rural areas of the transvaal. in both areas (eastern and northern transvaal), trichophyton violaceum was the predominant dermatophyte species which was isolated. microsporum audouinii was isolated in both areas from a total of 4 children, but m. canis was the cause of only 1 infection, and that was in the eastern transvaal. five infectio ...19761273736
[granulomatous mycosis caused by m. gypseum]. 19761274718
effect of reducing agents on proteolytic and keratinolytic activity of enzymes of microsporum gypseum.the effect of sodium sulphite, cysteine, glutathione, mercaptoethanol and dithioerythritol (0.1-10 mmol l-1) on the activity of proteases of microsporum gypseum was studied using azocasein, cross-linked bovine serum albumin and keratin as substrates. with the substrate without disulphide bonds (casein) no stimulation was found, and reducing agents inhibited proteolysis in most cases. with the remaining two substrates, all substances enhanced the activity of proteases probably through the cleavag ...19921284610
[epidemiology of tinea capitis in bangui (central african republic)].in bangui (central african republic) an epidemiological survey making use of cluster sampling has been performed. prevalence rate is not very high in bangui (3.4%). boys are more infected than girls. both in rural and urban area prevalence rates are decreasing with age. microsporum langeronii has been identified in 98% of case.19921292802
pattern of dermatophyte infection in singapore.dermatophyte infection is the fourth commonest skin disorder seen in the national skin centre in singapore. a prospective study was carried out from june 1990 to march 1991 to determine the epidemiology and pattern of dermatophyte infections seen in this centre. two hundred patients who had a clinical diagnosis of dermatophyte infection and confirmed by direct microscopy were included into the study. cultures for dermatophyte were done on sabouraud's dextrose agar with chloramphenicol and cycloh ...19921295417
structure modification and biological activity of some griseofulvin derivatives.griseofulvin is an orally acting anti-fungal antibiotic with very limited water solubility. five chemical modifications were made on the griseofulvin structure in order to evaluate these changes on the antifungal and water solubility properties. antifungal activity was measured against tricophyton mentagrophytes, t. rubrum, t. terrestre, and microsporum canis. the oxime of griseofulvin was the most potent of the five compounds tested, but it was only of equal or less potency than griseofulvin. t ...19921296044
low voltage scanning electron microscopy study of naftifine activity on microsporum canis.scanning electron microscopy (sem) is at present considered a good way to observe the morphological alterations induced by an antifungal on pathogenic fungi. owing to its high precision, low voltage scanning electron microscopy (lvsem) improves the quality of observations. the microsporum canis morphology alterations induced by naftifine at a concentration of 0.9 microgram ml-1 (10 times the minimum inhibitory concentration (mic) for 7 days were studied in lvsem. the young lateral ramifications ...19921302809
inhibition of growth of dermatophytes by indian hair oils.a survey on the use of hair oils for hair dressings by the indian population revealed that mustard oil is preferred by males and coconut oil by females. amla oil is used equally by both. these oils contain different percentages of various saturated and unsaturated fatty acids which largely determine their toxicity against dermatophytes. for microsporum canis, m. gypseum and trichophyton rubrum, amla oil was most toxic, followed by cantharidine and coconut oil, while trichophyton mentagrophytes w ...19921302812
in vitro and in vivo antidermatophytic activity of saperconazole, a new fluorinated triazole.the in vitro activity of saperconazole against selected isolates of dermatophytes and its in vivo efficacy in a guinea pig dermatophytic infection model using trichophyton mentagrophytes were evaluated. susceptibility testing was determined with an agar dilution method in three media: yeast nitrogen base agar (ynba), brain heart infusion agar (bhia) and sabouraud dextrose agar (sda). an inoculum of 1 x 10(5) cfu of t. mentagrophytes spores was placed onto the surface of these agars. incubation w ...19921308468
correlation between intracellular camp levels and phospholipids of microsporum gypseum.atropine, a modulator of camp has been used to examine the relationship between phospholipids and intracellular levels of camp in microsporum gypseum. a decreased phospholipid content was observed in atropine grown cells as a result of reduced levels of intracellular camp. this decline was caused by the inhibitory effect of atropine on adenylate cyclase. lowered phospholipid content was supported by decreased [14c]acetate incorporation as well as reduced activities of key enzymes of phospholipid ...19921311953
mycological findings in feline immunodeficiency virus-infected cats.thirty-five fiv-seropositive cats and 55 fiv-seronegative matched cats were examined for yeasts (oropharyngeal swabs) and dermatophytes (hair brushings). the frequency of isolation of candida albicans and cryptococcus neoformans was significantly higher in the former group. the only dermatophyte isolated was microsporum canis. its prevalence was three times higher among fiv-infected cats than among control animals.19921325555
outbreak of tinea capitis by trichophyton tonsurans and microsporum canis in niterói, rj, brazil.18 girls from an orphanage (orfanato santo antônio) in niterói presented tinea capitis due to trichophyton tonsurans (15 cases-83.3%) and microsporum canis (3 cases-26.7%). comments are made about clinical, mycological and therapeutic aspects of this microepidemic.19921342076
[microsporum nanum. a fourth report of human infection in brazil].the authors present the fourth brazilian case of human microsporum nanum (m. nanum) infection. a child of nine months old presents cutaneous dorsal lesions compatible with tinea corporis, which appeared one month before. the culture revealed m. nanum. the lesions resolved spontaneously after a month. epidemiologic investigation in the patient's place of origin identified swine infected by m. nanum, indicating the probable source of the infection.19921342128
phylogenetic relationships of the genera arthroderma and nannizzia inferred from mitochondrial dna analysis.the phylogenetic relationship of the genera arthroderma and nannizzia, was investigated by mitochondrial dna analysis based on the restriction-fragment-length polymorphisms. phylogenetic trees made on ten species. a. benhamiae, a. insingulare, a. quadrifidum, a. simii, a. vanbreuseghemii, n. fulva, n. grubyia, n. gypsea, n. incurvata and n. otae showed no definite distinctions between the genera arthroderma and nannizzia. these results support the conclusion of weitzman et al. that the genera ar ...19921359414
occurrence of keratinolytic fungi and related dermatophytes in soils in cairo, egypt.120 soil samples collected from various sites of cairo were processed for the isolation of keratinophilic fungi by "tokava" hair baiting technique. 22 species belonging to 6 genera were isolated viz.: chrysosporium tropicum, c. indicum, c. keratinophilum, c. queenslandicum, c. merdarium, c. anamorph of arthroderma curreyi, c. pannicola, c. lobatum, c. anamorph of renispora flavissima, c. pseudomerdarium, microascus mangini, malbranchea gypsea, ml. state of uncicarpus reesii, ml. state of coccidi ...19921380752
evaluation of keratinolytic potential of some fungal isolates from gelatin factory campus.during hair degradation, majority of organic sulphur was oxidized to inorganic sulphate and thiosulphate by four fungal isolates (cylindrocarpon lichenicola, graphium cuneiferum, microsporum gypseum, and m. fulvum) from gelatin factory soil. inorganic thiosulphate, an unusual metabolite, was regularly detected in the culture filtrates of all fungi, although in less amounts. maximum quantity (44 micrograms/ml) was released by g. cuneiferum on 50th day of incubation. all four fungi showed signific ...19921381699
keratinophilic fungi isolated from soil of italian parks in the province of pavia.soil samples collected from 9 parks in the italian province of pavia were baited with hair and feathers for the isolation of keratinophilic fungi. the dominant species were the teleomorphs arthroderma gypsea, a. uncinatum, ctenomyces serratus and aphanoascus fulvescens with their anamorphs. among the other species isolated, amauroascus mutatus, gymnascella dankaliensis, gymnoascus intermedius and gymnoascus reessii were recorded. the distribution of these fungi is discussed and related to previo ...19921383024
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